Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	170.0	8670.0	51.0	-0.041	0.826	1000.0	-1000.0	-0.082	-1000.0
Glypican 2 network	119.0	479.0	4.0	0.083	0.138	1000.0	-1000.0	0.016	-1000.0
Angiopoietin receptor Tie2-mediated signaling	92.0	8110.0	88.0	-0.505	0.103	1000.0	-1000.0	-0.048	-1000.0
Aurora B signaling	90.0	6063.0	67.0	-0.153	0.291	1000.0	-1000.0	-0.032	-1000.0
HIF-1-alpha transcription factor network	85.0	6492.0	76.0	-0.045	0.434	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by the Hedgehog family	67.0	3519.0	52.0	-0.232	0.11	1000.0	-1000.0	-0.032	-1000.0
PLK1 signaling events	57.0	4901.0	85.0	-0.054	0.205	1000.0	-1000.0	-0.021	-1000.0
Endothelins	54.0	5251.0	96.0	-0.301	0.199	1000.0	-1000.0	-0.045	-1000.0
Aurora C signaling	49.0	346.0	7.0	-0.0	0.172	1000.0	-1000.0	-0.004	-1000.0
Signaling mediated by p38-alpha and p38-beta	44.0	1944.0	44.0	-0.096	0.022	1000.0	-1000.0	-0.02	-1000.0
Signaling events regulated by Ret tyrosine kinase	42.0	3479.0	82.0	-0.084	0.065	1000.0	-1000.0	-0.042	-1000.0
FOXA2 and FOXA3 transcription factor networks	41.0	1899.0	46.0	-0.228	0.152	1000.0	-1000.0	-0.078	-1000.0
Osteopontin-mediated events	40.0	1543.0	38.0	-0.004	0.252	1000.0	-1000.0	-0.02	-1000.0
Visual signal transduction: Cones	39.0	1506.0	38.0	-0.084	0.12	1000.0	-1000.0	-0.017	-1000.0
Fc-epsilon receptor I signaling in mast cells	39.0	3812.0	97.0	-0.114	0.022	1000.0	-1000.0	-0.046	-1000.0
IL4-mediated signaling events	36.0	3322.0	91.0	-0.642	0.352	1000.0	-1000.0	-0.115	-1000.0
BMP receptor signaling	36.0	2976.0	81.0	-0.186	0.237	1000.0	-1000.0	-0.024	-1000.0
amb2 Integrin signaling	36.0	2993.0	82.0	-0.306	0.08	1000.0	-1000.0	-0.023	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	36.0	1904.0	52.0	-0.143	0.045	1000.0	-1000.0	-0.021	-1000.0
Ephrin B reverse signaling	34.0	1646.0	48.0	-0.078	0.08	1000.0	-1000.0	-0.022	-1000.0
Visual signal transduction: Rods	33.0	1726.0	52.0	-0.084	0.102	1000.0	-1000.0	-0.033	-1000.0
p75(NTR)-mediated signaling	28.0	3554.0	125.0	-0.141	0.142	1000.0	-1000.0	-0.051	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	27.0	1903.0	68.0	-0.152	0.066	1000.0	-1000.0	-0.056	-1000.0
IL23-mediated signaling events	27.0	1678.0	60.0	-0.182	0.027	1000.0	-1000.0	-0.078	-1000.0
Syndecan-1-mediated signaling events	25.0	867.0	34.0	-0.0	0.22	1000.0	-1000.0	-0.023	-1000.0
LPA4-mediated signaling events	24.0	299.0	12.0	-0.075	0.0	1000.0	-1000.0	-0.016	-1000.0
HIF-2-alpha transcription factor network	24.0	1032.0	43.0	-0.139	0.151	1000.0	-1000.0	-0.036	-1000.0
Integrins in angiogenesis	24.0	2087.0	84.0	-0.09	0.248	1000.0	-1000.0	-0.036	-1000.0
TCGA08_retinoblastoma	24.0	199.0	8.0	-0.021	0.099	1000.0	-1000.0	-0.002	-1000.0
Thromboxane A2 receptor signaling	23.0	2500.0	105.0	-0.105	0.074	1000.0	-1000.0	-0.035	-1000.0
Arf6 signaling events	23.0	1485.0	62.0	-0.108	0.074	1000.0	-1000.0	-0.023	-1000.0
Glucocorticoid receptor regulatory network	23.0	2720.0	114.0	-0.286	0.173	1000.0	-1000.0	-0.042	-1000.0
Canonical Wnt signaling pathway	23.0	1180.0	51.0	-0.212	0.095	1000.0	-1000.0	-0.03	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	23.0	2790.0	120.0	-0.163	0.143	1000.0	-1000.0	-0.04	-1000.0
Presenilin action in Notch and Wnt signaling	22.0	1359.0	61.0	-0.212	0.095	1000.0	-1000.0	-0.036	-1000.0
Reelin signaling pathway	21.0	1200.0	56.0	-0.04	0.047	1000.0	-1000.0	-0.026	-1000.0
Wnt signaling	21.0	150.0	7.0	-0.027	0.04	1000.0	-1000.0	-0.007	-1000.0
IL6-mediated signaling events	21.0	1586.0	75.0	-0.154	0.05	1000.0	-1000.0	-0.038	-1000.0
EGFR-dependent Endothelin signaling events	21.0	442.0	21.0	-0.022	0.074	1000.0	-1000.0	-0.032	-1000.0
Aurora A signaling	20.0	1251.0	60.0	-0.028	0.195	1000.0	-1000.0	-0.021	-1000.0
TCGA08_p53	20.0	144.0	7.0	-0.02	0.02	1000.0	-1000.0	-0.009	-1000.0
Noncanonical Wnt signaling pathway	19.0	495.0	26.0	-0.048	0.04	1000.0	-1000.0	-0.023	-1000.0
Glypican 1 network	19.0	929.0	48.0	-0.051	0.038	1000.0	-1000.0	-0.024	-1000.0
FoxO family signaling	18.0	1198.0	64.0	0.0	0.21	1000.0	-1000.0	-0.04	-1000.0
Effects of Botulinum toxin	18.0	489.0	26.0	-0.0	0.041	1000.0	-1000.0	-0.009	-1000.0
Nongenotropic Androgen signaling	18.0	968.0	52.0	-0.069	0.05	1000.0	-1000.0	-0.023	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	17.0	589.0	33.0	-0.08	0.097	1000.0	-1000.0	-0.031	-1000.0
ErbB2/ErbB3 signaling events	16.0	1071.0	65.0	-0.05	0.031	1000.0	-1000.0	-0.033	-1000.0
Syndecan-4-mediated signaling events	16.0	1072.0	67.0	-0.042	0.139	1000.0	-1000.0	-0.03	-1000.0
ErbB4 signaling events	15.0	1096.0	69.0	-0.114	0.137	1000.0	-1000.0	-0.025	-1000.0
Syndecan-2-mediated signaling events	15.0	1042.0	69.0	-0.044	0.06	1000.0	-1000.0	-0.031	-1000.0
PDGFR-alpha signaling pathway	15.0	678.0	44.0	-0.187	0.038	1000.0	-1000.0	-0.028	-1000.0
IL1-mediated signaling events	15.0	971.0	62.0	-0.077	0.042	1000.0	-1000.0	-0.043	-1000.0
Calcium signaling in the CD4+ TCR pathway	15.0	485.0	31.0	-0.035	0.037	1000.0	-1000.0	-0.028	-1000.0
PLK2 and PLK4 events	14.0	42.0	3.0	-0.006	0.04	1000.0	-1000.0	-0.017	-1000.0
FAS signaling pathway (CD95)	14.0	664.0	47.0	-0.226	0.035	1000.0	-1000.0	-0.033	-1000.0
EPHB forward signaling	14.0	1197.0	85.0	-0.034	0.091	1000.0	-1000.0	-0.044	-1000.0
LPA receptor mediated events	14.0	1511.0	102.0	-0.055	0.072	1000.0	-1000.0	-0.043	-1000.0
Regulation of Androgen receptor activity	14.0	1011.0	70.0	-0.141	0.124	1000.0	-1000.0	-0.03	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	13.0	447.0	34.0	-0.034	0.058	1000.0	-1000.0	-0.026	-1000.0
IL12-mediated signaling events	13.0	1132.0	87.0	-0.131	0.061	1000.0	-1000.0	-0.058	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	13.0	716.0	54.0	-0.033	0.109	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by PTP1B	13.0	997.0	76.0	-0.052	0.074	1000.0	-1000.0	-0.027	-1000.0
Plasma membrane estrogen receptor signaling	13.0	1171.0	86.0	-0.061	0.058	1000.0	-1000.0	-0.033	-1000.0
Class IB PI3K non-lipid kinase events	13.0	39.0	3.0	-0.008	0.008	1000.0	-1000.0	-0.019	-1000.0
S1P4 pathway	13.0	344.0	25.0	-0.028	0.028	1000.0	-1000.0	-0.016	-1000.0
Nectin adhesion pathway	12.0	771.0	63.0	-0.037	0.051	1000.0	-1000.0	-0.033	-1000.0
Ceramide signaling pathway	12.0	959.0	76.0	-0.021	0.074	1000.0	-1000.0	-0.034	-1000.0
S1P5 pathway	12.0	207.0	17.0	-0.02	0.021	1000.0	-1000.0	-0.006	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	12.0	945.0	78.0	-0.048	0.023	1000.0	-1000.0	-0.046	-1000.0
Coregulation of Androgen receptor activity	11.0	856.0	76.0	-0.063	0.096	1000.0	-1000.0	-0.025	-1000.0
BARD1 signaling events	11.0	627.0	57.0	-0.047	0.117	1000.0	-1000.0	-0.039	-1000.0
S1P1 pathway	11.0	404.0	36.0	-0.081	0.021	1000.0	-1000.0	-0.026	-1000.0
TCR signaling in naïve CD8+ T cells	11.0	1059.0	93.0	-0.028	0.033	1000.0	-1000.0	-0.035	-1000.0
BCR signaling pathway	11.0	1172.0	99.0	-0.045	0.081	1000.0	-1000.0	-0.043	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	10.0	887.0	85.0	-0.069	0.037	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class III	10.0	403.0	40.0	-0.06	0.068	1000.0	-1000.0	-0.033	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	10.0	804.0	74.0	-0.099	0.074	1000.0	-1000.0	-0.04	-1000.0
Caspase cascade in apoptosis	9.0	692.0	74.0	-0.029	0.084	1000.0	-1000.0	-0.033	-1000.0
Syndecan-3-mediated signaling events	9.0	335.0	35.0	-0.117	0.046	1000.0	-1000.0	-0.019	-1000.0
Regulation of p38-alpha and p38-beta	9.0	496.0	54.0	-0.04	0.057	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	9.0	1232.0	125.0	-0.187	0.042	1000.0	-1000.0	-0.044	-1000.0
IL2 signaling events mediated by STAT5	8.0	186.0	22.0	-0.027	0.105	1000.0	-1000.0	-0.026	-1000.0
Ephrin A  reverse signaling	7.0	52.0	7.0	-0.014	0.03	1000.0	-1000.0	-0.009	-1000.0
IL27-mediated signaling events	7.0	390.0	51.0	-0.045	0.039	1000.0	-1000.0	-0.046	-1000.0
Class I PI3K signaling events	7.0	551.0	73.0	-0.042	0.05	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by PRL	7.0	266.0	34.0	-0.025	0.089	1000.0	-1000.0	-0.03	-1000.0
Regulation of nuclear SMAD2/3 signaling	6.0	826.0	136.0	-0.179	0.072	1000.0	-1000.0	-0.025	-1000.0
JNK signaling in the CD4+ TCR pathway	6.0	103.0	17.0	-0.006	0.047	1000.0	-1000.0	-0.024	-1000.0
Cellular roles of Anthrax toxin	6.0	235.0	39.0	-0.034	0.029	1000.0	-1000.0	-0.014	-1000.0
Hedgehog signaling events mediated by Gli proteins	6.0	396.0	65.0	-0.139	0.049	1000.0	-1000.0	-0.031	-1000.0
mTOR signaling pathway	6.0	320.0	53.0	-0.056	0.025	1000.0	-1000.0	-0.029	-1000.0
IFN-gamma pathway	6.0	427.0	68.0	-0.029	0.062	1000.0	-1000.0	-0.038	-1000.0
Arf6 trafficking events	6.0	450.0	71.0	-0.039	0.039	1000.0	-1000.0	-0.029	-1000.0
Insulin Pathway	6.0	474.0	74.0	-0.106	0.051	1000.0	-1000.0	-0.038	-1000.0
VEGFR1 specific signals	6.0	372.0	56.0	-0.187	0.05	1000.0	-1000.0	-0.03	-1000.0
PDGFR-beta signaling pathway	6.0	669.0	97.0	-0.039	0.053	1000.0	-1000.0	-0.041	-1000.0
Sphingosine 1-phosphate (S1P) pathway	5.0	161.0	28.0	-0.02	0.033	1000.0	-1000.0	-0.018	-1000.0
EPO signaling pathway	5.0	311.0	55.0	-0.026	0.046	1000.0	-1000.0	-0.025	-1000.0
ceramide signaling pathway	5.0	275.0	49.0	-0.01	0.027	1000.0	-1000.0	-0.027	-1000.0
Retinoic acid receptors-mediated signaling	5.0	336.0	58.0	-0.096	0.041	1000.0	-1000.0	-0.029	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	5.0	261.0	45.0	-0.026	0.05	1000.0	-1000.0	-0.039	-1000.0
Regulation of Telomerase	5.0	581.0	102.0	-0.021	0.094	1000.0	-1000.0	-0.034	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	99.0	17.0	-0.004	0.031	1000.0	-1000.0	-0.018	-1000.0
Arf6 downstream pathway	4.0	200.0	43.0	-0.051	0.054	1000.0	-1000.0	-0.021	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	4.0	405.0	83.0	-0.061	0.041	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by HDAC Class I	4.0	452.0	104.0	-0.035	0.048	1000.0	-1000.0	-0.029	-1000.0
IL2 signaling events mediated by PI3K	4.0	244.0	58.0	-0.015	0.07	1000.0	-1000.0	-0.043	-1000.0
E-cadherin signaling in the nascent adherens junction	4.0	378.0	76.0	-0.033	0.055	1000.0	-1000.0	-0.038	-1000.0
p38 MAPK signaling pathway	4.0	199.0	44.0	-0.009	0.062	1000.0	-1000.0	-0.012	-1000.0
Signaling events mediated by HDAC Class II	3.0	256.0	75.0	-0.02	0.058	1000.0	-1000.0	-0.022	-1000.0
Circadian rhythm pathway	3.0	72.0	22.0	-0.004	0.05	1000.0	-1000.0	-0.027	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	239.0	68.0	-0.029	0.047	1000.0	-1000.0	-0.025	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	59.0	15.0	-0.019	0.022	1000.0	-1000.0	-0.024	-1000.0
TCGA08_rtk_signaling	3.0	91.0	26.0	-0.011	0.049	1000.0	-1000.0	-0.011	-1000.0
IGF1 pathway	3.0	180.0	57.0	-0.033	0.048	1000.0	-1000.0	-0.03	-1000.0
S1P3 pathway	3.0	138.0	42.0	-0.025	0.035	1000.0	-1000.0	-0.024	-1000.0
E-cadherin signaling in keratinocytes	3.0	164.0	43.0	-0.016	0.04	1000.0	-1000.0	-0.016	-1000.0
Canonical NF-kappaB pathway	2.0	89.0	39.0	-0.017	0.043	1000.0	-1000.0	-0.025	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	78.0	37.0	-0.026	0.051	1000.0	-1000.0	-0.018	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	7.0	5.0	0.02	0.031	1000.0	-1000.0	0.019	-1000.0
Insulin-mediated glucose transport	1.0	56.0	32.0	-0.017	0.038	1000.0	-1000.0	-0.023	-1000.0
TRAIL signaling pathway	1.0	82.0	48.0	-0.018	0.045	1000.0	-1000.0	-0.025	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	52.0	36.0	-0.036	0.039	1000.0	-1000.0	-0.027	-1000.0
Rapid glucocorticoid signaling	1.0	27.0	20.0	-0.008	0.027	1000.0	-1000.0	-0.01	-1000.0
E-cadherin signaling events	1.0	6.0	5.0	0.019	0.039	1000.0	-1000.0	0.017	-1000.0
Arf1 pathway	1.0	94.0	54.0	-0.008	0.035	1000.0	-1000.0	-0.015	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	22.0	23.0	-0.0	0.036	1000.0	-1000.0	-0.021	-1000.0
Atypical NF-kappaB pathway	0.0	26.0	31.0	-0.018	0.03	1000.0	-1000.0	-0.022	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	19.0	27.0	-0.02	0.045	1000.0	-1000.0	-0.027	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.056	1000.0	-1000.0	-0.0	-1000.0
Total	2439	144586	7203	-9.72929800827	10.9875844609	131000	-131000	-3.7936123257	-131000