Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.198 0.242 -9999.0 0.0 -0.668 23.0 23.0 IHH -0.331 0.329 -9999.0 0.0 -0.621 143.0 143.0 SHH Np/Cholesterol/GAS1 -0.046 0.143 -9999.0 0.0 -0.358 43.0 43.0 LRPAP1 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.046 0.142 0.356 43.0 -9999.0 0.0 43.0 SMO/beta Arrestin2 -0.233 0.236 -9999.0 0.0 -0.433 139.0 139.0 SMO -0.25 0.24 -9999.0 0.0 -0.453 140.0 140.0 AKT1 -0.125 0.167 -9999.0 0.0 -0.608 18.0 18.0 ARRB2 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.018 0.039 -9999.0 0.0 -0.595 1.0 1.0 ADRBK1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.246 0.236 -9999.0 0.0 -0.446 140.0 140.0 STIL -0.211 0.206 0.24 1.0 -0.467 62.0 63.0 DHH N/PTCH2 -0.014 0.141 -9999.0 0.0 -0.418 27.0 27.0 DHH N/PTCH1 -0.217 0.22 -9999.0 0.0 -0.376 157.0 157.0 PIK3CA 0.012 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.038 0.179 -9999.0 0.0 -0.595 24.0 24.0 PTHLH -0.242 0.277 -9999.0 0.0 -0.849 15.0 15.0 determination of left/right symmetry -0.246 0.236 -9999.0 0.0 -0.446 140.0 140.0 PIK3R1 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.24 0.275 -9999.0 0.0 -0.839 15.0 15.0 IHH N/Hhip -0.486 0.298 -9999.0 0.0 -0.612 207.0 207.0 DHH N/Hhip -0.318 0.246 -9999.0 0.0 -0.459 183.0 183.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.246 0.236 -9999.0 0.0 -0.446 140.0 140.0 pancreas development -0.373 0.294 -9999.0 0.0 -0.594 164.0 164.0 HHAT 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.016 0.017 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.013 0.077 -9999.0 0.0 -0.595 4.0 4.0 somite specification -0.246 0.236 -9999.0 0.0 -0.446 140.0 140.0 SHH Np/Cholesterol/PTCH1 -0.217 0.215 -9999.0 0.0 -0.372 152.0 152.0 SHH Np/Cholesterol/PTCH2 -0.043 0.138 -9999.0 0.0 -0.351 42.0 42.0 SHH Np/Cholesterol/Megalin -0.229 0.224 -9999.0 0.0 -0.403 149.0 149.0 SHH -0.08 0.157 -9999.0 0.0 -0.445 40.0 40.0 catabolic process -0.21 0.221 -9999.0 0.0 -0.395 144.0 144.0 SMO/Vitamin D3 -0.244 0.239 -9999.0 0.0 -0.429 140.0 140.0 SHH Np/Cholesterol/Hhip -0.275 0.209 -9999.0 0.0 -0.402 174.0 174.0 LRP2 -0.304 0.309 -9999.0 0.0 -0.595 136.0 136.0 receptor-mediated endocytosis -0.369 0.282 -9999.0 0.0 -0.612 125.0 125.0 SHH Np/Cholesterol/BOC -0.038 0.127 -9999.0 0.0 -0.35 34.0 34.0 SHH Np/Cholesterol/CDO -0.046 0.14 -9999.0 0.0 -0.35 44.0 44.0 mesenchymal cell differentiation 0.273 0.207 0.399 174.0 -9999.0 0.0 174.0 mol:Vitamin D3 -0.216 0.22 -9999.0 0.0 -0.376 149.0 149.0 IHH N/PTCH2 -0.206 0.22 -9999.0 0.0 -0.404 139.0 139.0 CDON 0.013 0.077 -9999.0 0.0 -0.595 4.0 4.0 IHH N/PTCH1 -0.205 0.233 -9999.0 0.0 -0.4 144.0 144.0 Megalin/LRPAP1 -0.219 0.235 -9999.0 0.0 -0.44 136.0 136.0 PTCH2 0.019 0.056 -9999.0 0.0 -0.595 2.0 2.0 SHH Np/Cholesterol -0.049 0.13 -9999.0 0.0 -0.347 40.0 40.0 PTCH1 -0.211 0.222 -9999.0 0.0 -0.397 144.0 144.0 HHIP -0.373 0.295 -9999.0 0.0 -0.595 164.0 164.0