Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.017 0.019 -9999.0 0.0 -0.27 1.0 1.0 epithelial cell differentiation 0.043 0.029 -9999.0 0.0 -0.33 1.0 1.0 CYFIP2 0.01 0.085 -9999.0 0.0 -0.595 5.0 5.0 ENAH 0.009 0.074 0.273 5.0 -9999.0 0.0 5.0 EGFR 0.016 0.109 0.377 6.0 -0.595 6.0 12.0 EPHA2 0.016 0.067 -9999.0 0.0 -0.595 3.0 3.0 MYO6 -0.009 0.034 -9999.0 0.0 -0.32 1.0 1.0 CTNNB1 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.034 0.057 -9999.0 0.0 -0.384 4.0 4.0 AQP5 -0.124 0.223 -9999.0 0.0 -0.499 65.0 65.0 CTNND1 0.023 0.001 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.009 0.032 -9999.0 0.0 -0.315 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.105 0.148 -9999.0 0.0 -0.319 81.0 81.0 EGF 0.003 0.107 -9999.0 0.0 -0.595 8.0 8.0 NCKAP1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.073 0.186 -9999.0 0.0 -0.498 40.0 40.0 cortical microtubule organization 0.043 0.029 -9999.0 0.0 -0.33 1.0 1.0 GO:0000145 -0.009 0.03 -9999.0 0.0 -0.301 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.047 0.03 -9999.0 0.0 -0.334 1.0 1.0 MLLT4 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.021 0.036 -9999.0 0.0 -0.296 3.0 3.0 ARF6 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.042 0.05 -9999.0 0.0 -0.354 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.001 0.019 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.009 0.032 -9999.0 0.0 -0.32 1.0 1.0 ARF6/GTP 0.045 0.05 -9999.0 0.0 -0.332 3.0 3.0 CDH1 0.02 0.039 -9999.0 0.0 -0.595 1.0 1.0 EGFR/EGFR/EGF/EGF 0.019 0.089 -9999.0 0.0 -0.334 14.0 14.0 RhoA/GDP 0.043 0.029 -9999.0 0.0 -0.317 1.0 1.0 actin cytoskeleton organization -0.011 0.029 -9999.0 0.0 -0.3 1.0 1.0 IGF-1R heterotetramer 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.014 0.077 -9999.0 0.0 -0.595 4.0 4.0 DIAPH1 -0.019 0.168 -9999.0 0.0 -0.556 13.0 13.0 Wnt receptor signaling pathway -0.043 0.029 0.33 1.0 -9999.0 0.0 1.0 RHOA 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.021 0.036 -9999.0 0.0 -0.295 4.0 4.0 CTNNA1 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.011 0.029 -9999.0 0.0 -0.306 1.0 1.0 EFNA1 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.007 0.019 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 0.033 0.047 -9999.0 0.0 -0.316 4.0 4.0 SEC6/SEC8 -0.016 0.021 -9999.0 0.0 -0.302 1.0 1.0 MGAT3 -0.107 0.151 -9999.0 0.0 -0.324 81.0 81.0 HGF/MET -0.021 0.136 -9999.0 0.0 -0.316 43.0 43.0 HGF -0.081 0.231 -9999.0 0.0 -0.595 43.0 43.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.017 0.019 -9999.0 0.0 -0.272 1.0 1.0 actin cable formation 0.048 0.1 0.301 14.0 -9999.0 0.0 14.0 KIAA1543 -0.009 0.032 -9999.0 0.0 -0.306 1.0 1.0 KIFC3 -0.01 0.031 -9999.0 0.0 -0.32 1.0 1.0 NCK1 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.018 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.009 0.033 -9999.0 0.0 -0.303 1.0 1.0 NCK1/GIT1 0.029 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.043 0.029 -9999.0 0.0 -0.33 1.0 1.0 EXOC4 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.009 0.034 -9999.0 0.0 -0.32 1.0 1.0 PIP5K1C -0.009 0.032 -9999.0 0.0 -0.32 1.0 1.0 LIMA1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.016 0.09 0.31 8.0 -9999.0 0.0 8.0 adherens junction assembly -0.007 0.067 0.258 1.0 -0.682 1.0 2.0 IGF-1R heterotetramer/IGF1 0.033 0.051 -9999.0 0.0 -0.309 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.019 0.059 0.377 1.0 -0.595 2.0 3.0 PLEKHA7 -0.009 0.034 -9999.0 0.0 -0.32 1.0 1.0 mol:GTP 0.04 0.049 -9999.0 0.0 -0.351 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.026 0.089 0.346 5.0 -9999.0 0.0 5.0 cortical actin cytoskeleton stabilization 0.017 0.019 -9999.0 0.0 -0.27 1.0 1.0 regulation of cell-cell adhesion -0.011 0.029 -9999.0 0.0 -0.3 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.017 0.019 -9999.0 0.0 -0.272 1.0 1.0