E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.093 0.186 -9999.0 0.0 -0.381 68.0 68.0 KLHL20 -0.019 0.08 -9999.0 0.0 -0.21 10.0 10.0 CYFIP2 -0.008 0.09 -9999.0 0.0 -0.392 12.0 12.0 Rac1/GDP -0.034 0.115 -9999.0 0.0 -0.211 65.0 65.0 ENAH -0.097 0.189 -9999.0 0.0 -0.386 68.0 68.0 AP1M1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.012 0.018 -9999.0 0.0 -0.255 1.0 1.0 RAP1A 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.042 0.06 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.033 0.046 -9999.0 0.0 -0.151 14.0 14.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.055 0.119 -9999.0 0.0 -0.212 77.0 77.0 RAPGEF1 -0.072 0.165 -9999.0 0.0 -0.327 68.0 68.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.1 0.191 -9999.0 0.0 -0.396 68.0 68.0 CRK -0.082 0.176 -9999.0 0.0 -0.355 68.0 68.0 E-cadherin/gamma catenin/alpha catenin -0.06 0.12 -9999.0 0.0 -0.234 68.0 68.0 alphaE/beta7 Integrin 0.001 0.071 -9999.0 0.0 -0.269 15.0 15.0 IQGAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.023 0.025 -9999.0 0.0 -0.203 2.0 2.0 DLG1 -0.092 0.186 -9999.0 0.0 -0.381 68.0 68.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.032 0.045 -9999.0 0.0 -0.174 1.0 1.0 MLLT4 0.009 0.042 -9999.0 0.0 -0.355 3.0 3.0 ARF6/GTP/NME1/Tiam1 0.011 0.057 -9999.0 0.0 -0.203 15.0 15.0 PI3K -0.039 0.056 -9999.0 0.0 -0.223 1.0 1.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.082 0.141 -9999.0 0.0 -0.263 84.0 84.0 TIAM1 -0.015 0.104 -9999.0 0.0 -0.395 16.0 16.0 E-cadherin(dimer)/Ca2+ -0.039 0.099 -9999.0 0.0 -0.185 68.0 68.0 AKT1 -0.023 0.033 -9999.0 0.0 -0.128 1.0 1.0 PIK3R1 0.01 0.039 -9999.0 0.0 -0.404 2.0 2.0 CDH1 -0.124 0.191 -9999.0 0.0 -0.38 81.0 81.0 RhoA/GDP -0.034 0.115 -9999.0 0.0 -0.211 65.0 65.0 actin cytoskeleton organization -0.013 0.061 -9999.0 0.0 -0.153 10.0 10.0 CDC42/GDP -0.034 0.115 -9999.0 0.0 -0.211 65.0 65.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.051 0.104 -9999.0 0.0 -0.207 68.0 68.0 ITGB7 -0.013 0.101 -9999.0 0.0 -0.394 15.0 15.0 RAC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.041 0.106 -9999.0 0.0 -0.198 68.0 68.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.046 0.097 -9999.0 0.0 -0.19 68.0 68.0 mol:GDP -0.047 0.129 -9999.0 0.0 -0.244 68.0 68.0 CDC42/GTP/IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.005 0.052 -9999.0 0.0 -0.305 6.0 6.0 p120 catenin/RhoA/GDP -0.035 0.117 -9999.0 0.0 -0.214 65.0 65.0 RAC1/GTP/IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.007 0.047 -9999.0 0.0 -0.145 7.0 7.0 NME1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.096 0.187 -9999.0 0.0 -0.383 68.0 68.0 regulation of cell-cell adhesion -0.037 0.053 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.017 0.025 -9999.0 0.0 -0.106 2.0 2.0 Rap1/GTP -0.021 0.087 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.049 0.117 -9999.0 0.0 -0.201 77.0 77.0 CCND1 -0.009 0.056 -9999.0 0.0 -0.179 7.0 7.0 VAV2 -0.092 0.2 -9999.0 0.0 -0.378 72.0 72.0 RAP1/GDP -0.026 0.096 -9999.0 0.0 -0.205 1.0 1.0 adherens junction assembly -0.093 0.182 -9999.0 0.0 -0.372 68.0 68.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.043 0.111 -9999.0 0.0 -0.187 77.0 77.0 E-cadherin/beta catenin -0.083 0.14 -9999.0 0.0 -0.299 68.0 68.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.092 0.186 -9999.0 0.0 -0.38 68.0 68.0 PIK3CA 0.01 0.039 -9999.0 0.0 -0.404 2.0 2.0 Rac1/GTP -0.067 0.097 -9999.0 0.0 -0.34 10.0 10.0 E-cadherin/beta catenin/alpha catenin -0.055 0.115 -9999.0 0.0 -0.225 68.0 68.0 ITGAE 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.102 0.195 -9999.0 0.0 -0.404 68.0 68.0