Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.035 0.178 -9999.0 0.0 -0.527 21.0 21.0 IHH -0.004 0.057 -9999.0 0.0 -0.27 5.0 5.0 SHH Np/Cholesterol/GAS1 0.004 0.047 -9999.0 0.0 -0.206 8.0 8.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.004 0.047 0.205 8.0 -9999.0 0.0 8.0 SMO/beta Arrestin2 -0.03 0.14 -9999.0 0.0 -0.443 13.0 13.0 SMO -0.038 0.146 -9999.0 0.0 -0.445 15.0 15.0 AKT1 -0.004 0.077 -9999.0 0.0 -0.247 7.0 7.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.012 0.089 -9999.0 0.0 -0.302 19.0 19.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.037 0.145 -9999.0 0.0 -0.438 15.0 15.0 STIL -0.009 0.097 -9999.0 0.0 -0.336 10.0 10.0 DHH N/PTCH2 -0.02 0.089 -9999.0 0.0 -0.203 42.0 42.0 DHH N/PTCH1 -0.029 0.128 -9999.0 0.0 -0.337 21.0 21.0 PIK3CA 0.01 0.039 -9999.0 0.0 -0.404 2.0 2.0 DHH -0.031 0.11 -9999.0 0.0 -0.29 34.0 34.0 PTHLH -0.049 0.233 -9999.0 0.0 -0.778 18.0 18.0 determination of left/right symmetry -0.037 0.145 -9999.0 0.0 -0.438 15.0 15.0 PIK3R1 0.01 0.039 -9999.0 0.0 -0.404 2.0 2.0 skeletal system development -0.048 0.23 -9999.0 0.0 -0.769 18.0 18.0 IHH N/Hhip -0.005 0.064 -9999.0 0.0 -0.216 16.0 16.0 DHH N/Hhip -0.026 0.088 -9999.0 0.0 -0.193 47.0 47.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.037 0.145 -9999.0 0.0 -0.438 15.0 15.0 pancreas development -0.009 0.067 -9999.0 0.0 -0.255 16.0 16.0 HHAT 0.004 0.061 -9999.0 0.0 -0.404 5.0 5.0 PI3K 0.015 0.045 -9999.0 0.0 -0.358 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.007 0.05 -9999.0 0.0 -0.367 4.0 4.0 somite specification -0.037 0.145 -9999.0 0.0 -0.438 15.0 15.0 SHH Np/Cholesterol/PTCH1 -0.013 0.102 -9999.0 0.0 -0.357 10.0 10.0 SHH Np/Cholesterol/PTCH2 0.0 0.053 -9999.0 0.0 -0.21 10.0 10.0 SHH Np/Cholesterol/Megalin -0.091 0.105 -9999.0 0.0 -0.231 60.0 60.0 SHH -0.001 0.053 -9999.0 0.0 -0.209 13.0 13.0 catabolic process -0.015 0.121 -9999.0 0.0 -0.369 18.0 18.0 SMO/Vitamin D3 -0.023 0.119 -9999.0 0.0 -0.382 14.0 14.0 SHH Np/Cholesterol/Hhip -0.004 0.054 -9999.0 0.0 -0.234 7.0 7.0 LRP2 -0.178 0.174 -9999.0 0.0 -0.32 133.0 133.0 receptor-mediated endocytosis -0.085 0.144 -9999.0 0.0 -0.439 20.0 20.0 SHH Np/Cholesterol/BOC -0.006 0.059 -9999.0 0.0 -0.208 11.0 11.0 SHH Np/Cholesterol/CDO 0.005 0.05 -9999.0 0.0 -0.236 7.0 7.0 mesenchymal cell differentiation 0.004 0.054 0.233 7.0 -9999.0 0.0 7.0 mol:Vitamin D3 -0.01 0.103 -9999.0 0.0 -0.359 10.0 10.0 IHH N/PTCH2 0.001 0.065 -9999.0 0.0 -0.271 10.0 10.0 CDON 0.008 0.047 -9999.0 0.0 -0.404 3.0 3.0 IHH N/PTCH1 -0.013 0.123 -9999.0 0.0 -0.371 18.0 18.0 Megalin/LRPAP1 -0.114 0.122 -9999.0 0.0 -0.277 58.0 58.0 PTCH2 -0.001 0.068 -9999.0 0.0 -0.315 10.0 10.0 SHH Np/Cholesterol 0.001 0.04 -9999.0 0.0 -0.213 5.0 5.0 PTCH1 -0.015 0.122 -9999.0 0.0 -0.371 18.0 18.0 HHIP -0.009 0.067 -9999.0 0.0 -0.255 16.0 16.0