Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.042 0.098 -9999.0 0.0 -0.193 68.0 68.0 epithelial cell differentiation -0.04 0.097 -9999.0 0.0 -0.183 68.0 68.0 CYFIP2 -0.008 0.09 -9999.0 0.0 -0.392 12.0 12.0 ENAH -0.015 0.076 -9999.0 0.0 -0.218 6.0 6.0 EGFR -0.019 0.098 -9999.0 0.0 -0.299 24.0 24.0 EPHA2 -0.001 0.072 -9999.0 0.0 -0.355 9.0 9.0 MYO6 -0.043 0.095 -9999.0 0.0 -0.175 75.0 75.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.015 0.055 -9999.0 0.0 -0.225 11.0 11.0 AQP5 -0.042 0.1 -9999.0 0.0 -0.489 4.0 4.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.036 0.089 -9999.0 0.0 -0.168 68.0 68.0 regulation of calcium-dependent cell-cell adhesion -0.047 0.1 -9999.0 0.0 -0.184 72.0 72.0 EGF -0.09 0.17 -9999.0 0.0 -0.36 64.0 64.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.052 0.136 -9999.0 0.0 -0.466 15.0 15.0 cortical microtubule organization -0.04 0.097 -9999.0 0.0 -0.183 68.0 68.0 GO:0000145 -0.036 0.084 -9999.0 0.0 -0.161 68.0 68.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.039 0.099 -9999.0 0.0 -0.185 68.0 68.0 MLLT4 0.009 0.042 -9999.0 0.0 -0.355 3.0 3.0 ARF6/GDP -0.047 0.064 -9999.0 0.0 -0.233 3.0 3.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.027 0.04 -9999.0 0.0 -0.198 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.029 0.086 -9999.0 0.0 -0.199 2.0 2.0 PVRL2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.037 0.092 -9999.0 0.0 -0.174 68.0 68.0 ARF6/GTP 0.031 0.037 -9999.0 0.0 -0.178 6.0 6.0 CDH1 -0.124 0.191 -9999.0 0.0 -0.38 81.0 81.0 EGFR/EGFR/EGF/EGF -0.105 0.118 -9999.0 0.0 -0.323 36.0 36.0 RhoA/GDP -0.035 0.09 -9999.0 0.0 -0.169 68.0 68.0 actin cytoskeleton organization -0.039 0.093 -9999.0 0.0 -0.169 69.0 69.0 IGF-1R heterotetramer 0.009 0.042 -9999.0 0.0 -0.354 3.0 3.0 GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.009 0.042 -9999.0 0.0 -0.355 3.0 3.0 IGF1 -0.022 0.113 -9999.0 0.0 -0.376 21.0 21.0 DIAPH1 -0.021 0.125 -9999.0 0.0 -0.58 11.0 11.0 Wnt receptor signaling pathway 0.04 0.097 0.183 68.0 -9999.0 0.0 68.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.048 0.065 -9999.0 0.0 -0.233 3.0 3.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.04 0.095 -9999.0 0.0 -0.172 69.0 69.0 EFNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.034 0.087 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.057 0.077 -9999.0 0.0 -0.165 74.0 74.0 SEC6/SEC8 -0.048 0.065 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.048 0.101 -9999.0 0.0 -0.187 72.0 72.0 HGF/MET -0.087 0.106 -9999.0 0.0 -0.206 90.0 90.0 HGF -0.026 0.11 -9999.0 0.0 -0.322 27.0 27.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.043 0.099 -9999.0 0.0 -0.194 68.0 68.0 actin cable formation -0.004 0.077 -9999.0 0.0 -0.247 3.0 3.0 KIAA1543 -0.07 0.113 -9999.0 0.0 -0.196 86.0 86.0 KIFC3 -0.037 0.091 -9999.0 0.0 -0.17 69.0 69.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.018 -9999.0 0.0 -0.255 1.0 1.0 ACTN1 -0.04 0.092 -9999.0 0.0 -0.171 72.0 72.0 NCK1/GIT1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.04 0.097 -9999.0 0.0 -0.183 68.0 68.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.036 0.09 -9999.0 0.0 -0.17 68.0 68.0 PIP5K1C -0.036 0.09 -9999.0 0.0 -0.17 68.0 68.0 LIMA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.018 0.079 -9999.0 0.0 -0.206 3.0 3.0 adherens junction assembly -0.054 0.111 -9999.0 0.0 -0.286 21.0 21.0 IGF-1R heterotetramer/IGF1 -0.068 0.09 -9999.0 0.0 -0.328 9.0 9.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.017 0.03 -9999.0 0.0 -0.239 3.0 3.0 MET -0.038 0.131 -9999.0 0.0 -0.358 32.0 32.0 PLEKHA7 -0.048 0.103 -9999.0 0.0 -0.186 75.0 75.0 mol:GTP 0.026 0.04 -9999.0 0.0 -0.197 6.0 6.0 establishment of epithelial cell apical/basal polarity -0.017 0.082 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.042 0.098 -9999.0 0.0 -0.193 68.0 68.0 regulation of cell-cell adhesion -0.039 0.093 -9999.0 0.0 -0.169 69.0 69.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.043 0.099 -9999.0 0.0 -0.194 68.0 68.0