E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.099 0.186 0.229 1.0 -0.363 75.0 76.0 KLHL20 -0.03 0.094 0.182 6.0 -0.212 21.0 27.0 CYFIP2 0.014 0.067 0.123 1.0 -0.315 9.0 10.0 Rac1/GDP -0.046 0.118 0.208 3.0 -0.227 53.0 56.0 ENAH -0.095 0.181 0.223 1.0 -0.362 70.0 71.0 AP1M1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.019 0.082 0.138 1.0 -0.154 49.0 50.0 ABI1/Sra1/Nap1 -0.041 0.054 -9999.0 0.0 -0.143 27.0 27.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.008 0.115 -9999.0 0.0 -0.175 71.0 71.0 RAPGEF1 -0.081 0.168 0.219 3.0 -0.327 68.0 71.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.096 0.195 -9999.0 0.0 -0.374 75.0 75.0 CRK -0.087 0.176 0.186 4.0 -0.342 71.0 75.0 E-cadherin/gamma catenin/alpha catenin -0.012 0.113 -9999.0 0.0 -0.191 63.0 63.0 alphaE/beta7 Integrin 0.027 0.058 -9999.0 0.0 -0.215 12.0 12.0 IQGAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.043 0.029 -9999.0 0.0 -0.155 2.0 2.0 DLG1 -0.099 0.185 -9999.0 0.0 -0.366 74.0 74.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.041 0.047 -9999.0 0.0 -0.121 50.0 50.0 MLLT4 0.022 0.033 -9999.0 0.0 -0.315 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.041 0.05 -9999.0 0.0 -0.165 12.0 12.0 PI3K -0.051 0.059 -9999.0 0.0 -0.152 50.0 50.0 ARF6 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.029 0.123 -9999.0 0.0 -0.225 63.0 63.0 TIAM1 0.01 0.076 0.123 1.0 -0.315 12.0 13.0 E-cadherin(dimer)/Ca2+ 0.002 0.102 -9999.0 0.0 -0.159 63.0 63.0 AKT1 -0.024 0.051 0.127 3.0 -0.125 1.0 4.0 PIK3R1 0.025 0.032 -9999.0 0.0 -0.315 2.0 2.0 CDH1 -0.061 0.157 0.123 12.0 -0.315 63.0 75.0 RhoA/GDP -0.044 0.128 0.24 5.0 -0.226 58.0 63.0 actin cytoskeleton organization -0.02 0.073 0.156 7.0 -0.155 21.0 28.0 CDC42/GDP -0.044 0.128 0.24 5.0 -0.226 58.0 63.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.037 0.094 -9999.0 0.0 -0.188 63.0 63.0 ITGB7 0.011 0.077 -9999.0 0.0 -0.315 12.0 12.0 RAC1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.003 0.109 -9999.0 0.0 -0.171 63.0 63.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.007 0.093 -9999.0 0.0 -0.155 63.0 63.0 mol:GDP -0.061 0.135 0.243 5.0 -0.255 58.0 63.0 CDC42/GTP/IQGAP1 0.036 0.01 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.027 0.035 0.123 4.0 -0.315 2.0 6.0 p120 catenin/RhoA/GDP -0.039 0.132 0.229 4.0 -0.232 56.0 60.0 RAC1/GTP/IQGAP1 0.033 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.043 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.01 0.056 0.134 9.0 -0.108 20.0 29.0 NME1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.103 0.187 -9999.0 0.0 -0.368 75.0 75.0 regulation of cell-cell adhesion -0.026 0.065 -9999.0 0.0 -0.138 49.0 49.0 WASF2 -0.014 0.04 0.092 3.0 -0.089 11.0 14.0 Rap1/GTP -0.019 0.095 0.186 12.0 -0.167 50.0 62.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.0 0.119 -9999.0 0.0 -0.17 71.0 71.0 CCND1 -0.013 0.067 0.153 9.0 -0.131 20.0 29.0 VAV2 -0.121 0.248 0.355 1.0 -0.637 23.0 24.0 RAP1/GDP -0.025 0.108 0.264 3.0 -0.183 54.0 57.0 adherens junction assembly -0.1 0.182 -9999.0 0.0 -0.357 75.0 75.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.011 0.109 0.208 3.0 -0.168 70.0 73.0 E-cadherin/beta catenin -0.065 0.128 -9999.0 0.0 -0.276 62.0 62.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.097 0.181 0.224 1.0 -0.356 74.0 75.0 PIK3CA 0.025 0.032 -9999.0 0.0 -0.315 2.0 2.0 Rac1/GTP -0.076 0.124 -9999.0 0.0 -0.334 24.0 24.0 E-cadherin/beta catenin/alpha catenin -0.011 0.109 -9999.0 0.0 -0.186 63.0 63.0 ITGAE 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.099 0.198 -9999.0 0.0 -0.381 75.0 75.0