Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.017 0.118 -9999.0 0.0 -0.467 11.0 11.0 IHH 0.033 0.053 0.144 6.0 -0.137 16.0 22.0 SHH Np/Cholesterol/GAS1 0.016 0.028 -9999.0 0.0 -0.168 4.0 4.0 LRPAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.015 0.027 0.168 4.0 -9999.0 0.0 4.0 SMO/beta Arrestin2 0.012 0.129 -9999.0 0.0 -0.355 12.0 12.0 SMO -0.011 0.118 -9999.0 0.0 -0.364 14.0 14.0 AKT1 -0.0 0.102 -9999.0 0.0 -0.376 9.0 9.0 ARRB2 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.024 0.06 0.123 13.0 -0.315 6.0 19.0 ADRBK1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.011 0.117 -9999.0 0.0 -0.359 14.0 14.0 STIL 0.023 0.089 0.188 31.0 -0.23 13.0 44.0 DHH N/PTCH2 0.037 0.066 0.18 2.0 -0.22 12.0 14.0 DHH N/PTCH1 0.026 0.108 -9999.0 0.0 -0.3 19.0 19.0 PIK3CA 0.025 0.032 -9999.0 0.0 -0.315 2.0 2.0 DHH 0.026 0.071 0.123 25.0 -0.315 8.0 33.0 PTHLH -0.001 0.175 -9999.0 0.0 -0.621 15.0 15.0 determination of left/right symmetry -0.011 0.117 -9999.0 0.0 -0.359 14.0 14.0 PIK3R1 0.025 0.032 -9999.0 0.0 -0.315 2.0 2.0 skeletal system development -0.0 0.173 -9999.0 0.0 -0.615 15.0 15.0 IHH N/Hhip 0.045 0.043 0.189 3.0 -9999.0 0.0 3.0 DHH N/Hhip 0.042 0.058 0.18 3.0 -0.22 8.0 11.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.011 0.117 -9999.0 0.0 -0.359 14.0 14.0 pancreas development 0.022 0.034 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.018 0.05 -9999.0 0.0 -0.315 5.0 5.0 PI3K 0.036 0.039 -9999.0 0.0 -0.279 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.024 0.033 0.123 1.0 -0.315 2.0 3.0 somite specification -0.011 0.117 -9999.0 0.0 -0.359 14.0 14.0 SHH Np/Cholesterol/PTCH1 0.01 0.069 -9999.0 0.0 -0.237 13.0 13.0 SHH Np/Cholesterol/PTCH2 0.017 0.036 0.158 2.0 -0.169 6.0 8.0 SHH Np/Cholesterol/Megalin 0.003 0.103 0.194 13.0 -0.171 49.0 62.0 SHH -0.013 0.027 -9999.0 0.0 -0.223 3.0 3.0 catabolic process 0.01 0.104 0.176 1.0 -0.356 16.0 17.0 SMO/Vitamin D3 0.008 0.098 0.212 13.0 -0.28 14.0 27.0 SHH Np/Cholesterol/Hhip 0.015 0.039 0.166 5.0 -0.167 3.0 8.0 LRP2 -0.029 0.171 0.123 74.0 -0.315 58.0 132.0 receptor-mediated endocytosis -0.026 0.119 0.198 5.0 -0.3 23.0 28.0 SHH Np/Cholesterol/BOC 0.018 0.04 0.202 1.0 -0.169 7.0 8.0 SHH Np/Cholesterol/CDO 0.014 0.035 -9999.0 0.0 -0.198 5.0 5.0 mesenchymal cell differentiation -0.015 0.038 0.166 3.0 -0.164 5.0 8.0 mol:Vitamin D3 0.038 0.099 0.213 32.0 -0.238 13.0 45.0 IHH N/PTCH2 0.038 0.053 0.202 1.0 -0.16 8.0 9.0 CDON 0.021 0.04 -9999.0 0.0 -0.315 3.0 3.0 IHH N/PTCH1 0.022 0.109 0.229 1.0 -0.358 16.0 17.0 Megalin/LRPAP1 -0.004 0.128 -9999.0 0.0 -0.219 58.0 58.0 PTCH2 0.025 0.048 0.123 6.0 -0.315 4.0 10.0 SHH Np/Cholesterol 0.009 0.021 -9999.0 0.0 -0.165 3.0 3.0 PTCH1 0.01 0.104 0.177 1.0 -0.357 16.0 17.0 HHIP 0.022 0.034 -9999.0 0.0 -9999.0 0.0 0.0