Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.033 0.091 -9999.0 0.0 -0.179 64.0 64.0 epithelial cell differentiation -0.001 0.098 -9999.0 0.0 -0.158 63.0 63.0 CYFIP2 0.014 0.067 0.123 1.0 -0.315 9.0 10.0 ENAH -0.046 0.069 0.417 1.0 -0.235 3.0 4.0 EGFR 0.023 0.061 0.123 16.0 -0.315 6.0 22.0 EPHA2 0.02 0.056 0.123 3.0 -0.315 6.0 9.0 MYO6 -0.047 0.078 0.203 6.0 -0.157 64.0 70.0 CTNNB1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.042 0.049 -9999.0 0.0 -0.18 9.0 9.0 AQP5 -0.026 0.091 0.426 1.0 -0.432 4.0 5.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.044 0.075 0.202 6.0 -0.153 61.0 67.0 regulation of calcium-dependent cell-cell adhesion -0.044 0.079 0.22 5.0 -0.158 56.0 61.0 EGF -0.029 0.139 -9999.0 0.0 -0.315 43.0 43.0 NCKAP1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.049 0.115 0.383 1.0 -0.34 20.0 21.0 cortical microtubule organization -0.001 0.098 -9999.0 0.0 -0.158 63.0 63.0 GO:0000145 -0.044 0.071 0.189 6.0 -0.146 61.0 67.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.002 0.102 -9999.0 0.0 -0.159 63.0 63.0 MLLT4 0.022 0.033 -9999.0 0.0 -0.315 2.0 2.0 ARF6/GDP -0.056 0.058 -9999.0 0.0 -0.15 58.0 58.0 ARF6 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.056 0.047 -9999.0 0.0 -0.167 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.034 0.068 0.209 4.0 -9999.0 0.0 4.0 PVRL2 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.042 0.072 0.215 4.0 -0.155 56.0 60.0 ARF6/GTP 0.061 0.049 -9999.0 0.0 -0.158 6.0 6.0 CDH1 -0.061 0.157 0.123 12.0 -0.315 63.0 75.0 EGFR/EGFR/EGF/EGF -0.039 0.113 -9999.0 0.0 -0.17 91.0 91.0 RhoA/GDP 0.0 0.096 -9999.0 0.0 -0.153 63.0 63.0 actin cytoskeleton organization -0.052 0.077 0.187 6.0 -0.161 55.0 61.0 IGF-1R heterotetramer 0.025 0.032 -9999.0 0.0 -0.315 2.0 2.0 GIT1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.025 0.032 -9999.0 0.0 -0.315 2.0 2.0 IGF1 0.008 0.086 0.123 4.0 -0.315 15.0 19.0 DIAPH1 -0.031 0.211 -9999.0 0.0 -0.557 23.0 23.0 Wnt receptor signaling pathway 0.001 0.098 0.158 63.0 -9999.0 0.0 63.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.056 0.058 -9999.0 0.0 -0.151 59.0 59.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.053 0.078 0.189 6.0 -0.164 55.0 61.0 EFNA1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.05 0.074 0.195 6.0 -0.152 65.0 71.0 Ephrin A1/EPHA2 -0.009 0.09 -9999.0 0.0 -0.152 62.0 62.0 SEC6/SEC8 -0.048 0.059 -9999.0 0.0 -0.151 55.0 55.0 MGAT3 -0.045 0.08 0.222 5.0 -0.16 56.0 61.0 HGF/MET -0.022 0.106 -9999.0 0.0 -0.169 72.0 72.0 HGF 0.014 0.077 0.123 13.0 -0.315 11.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.033 0.092 -9999.0 0.0 -0.181 64.0 64.0 actin cable formation -0.017 0.108 0.28 13.0 -0.249 5.0 18.0 KIAA1543 -0.048 0.075 0.191 6.0 -0.152 62.0 68.0 KIFC3 -0.048 0.073 0.219 4.0 -0.155 62.0 66.0 NCK1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.047 0.077 0.203 6.0 -0.155 65.0 71.0 NCK1/GIT1 0.04 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.001 0.098 -9999.0 0.0 -0.158 63.0 63.0 EXOC4 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.046 0.077 0.203 6.0 -0.155 62.0 68.0 PIP5K1C -0.045 0.076 0.203 6.0 -0.155 61.0 67.0 LIMA1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.034 0.098 0.365 5.0 -9999.0 0.0 5.0 adherens junction assembly -0.046 0.09 0.319 2.0 -0.305 8.0 10.0 IGF-1R heterotetramer/IGF1 -0.018 0.102 -9999.0 0.0 -0.162 73.0 73.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.034 0.028 -9999.0 0.0 -0.22 2.0 2.0 MET 0.002 0.094 0.123 7.0 -0.315 18.0 25.0 PLEKHA7 -0.048 0.081 0.203 6.0 -0.159 62.0 68.0 mol:GTP 0.054 0.046 -9999.0 0.0 -0.166 6.0 6.0 establishment of epithelial cell apical/basal polarity -0.017 0.111 0.303 9.0 -9999.0 0.0 9.0 cortical actin cytoskeleton stabilization -0.033 0.091 -9999.0 0.0 -0.179 64.0 64.0 regulation of cell-cell adhesion -0.052 0.077 0.187 6.0 -0.161 55.0 61.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.033 0.092 -9999.0 0.0 -0.181 64.0 64.0