Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	46.0	328.0	7.0	-0.047	0.0	1000.0	-1000.0	-0.011	-1000.0
E-cadherin signaling events	41.0	207.0	5.0	-0.061	0.028	1000.0	-1000.0	0.015	-1000.0
TCR signaling in naïve CD8+ T cells	36.0	3398.0	93.0	-0.203	0.132	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	35.0	2757.0	78.0	-0.214	0.071	1000.0	-1000.0	-0.037	-1000.0
IL23-mediated signaling events	34.0	2053.0	60.0	-0.281	0.028	1000.0	-1000.0	-0.05	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	33.0	2513.0	74.0	-0.061	0.061	1000.0	-1000.0	-0.041	-1000.0
IL4-mediated signaling events	32.0	2973.0	91.0	-0.494	0.38	1000.0	-1000.0	-0.079	-1000.0
E-cadherin signaling in the nascent adherens junction	32.0	2437.0	76.0	-0.121	0.043	1000.0	-1000.0	-0.034	-1000.0
Signaling events regulated by Ret tyrosine kinase	30.0	2505.0	82.0	-0.055	0.029	1000.0	-1000.0	-0.029	-1000.0
Angiopoietin receptor Tie2-mediated signaling	30.0	2716.0	88.0	-0.211	0.039	1000.0	-1000.0	-0.06	-1000.0
Endothelins	28.0	2770.0	96.0	-0.116	0.05	1000.0	-1000.0	-0.023	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	28.0	1946.0	68.0	-0.289	0.082	1000.0	-1000.0	-0.047	-1000.0
IL12-mediated signaling events	27.0	2393.0	87.0	-0.269	0.061	1000.0	-1000.0	-0.04	-1000.0
BCR signaling pathway	26.0	2647.0	99.0	-0.145	0.035	1000.0	-1000.0	-0.037	-1000.0
E-cadherin signaling in keratinocytes	26.0	1154.0	43.0	-0.066	0.031	1000.0	-1000.0	-0.015	-1000.0
Wnt signaling	23.0	161.0	7.0	-0.024	0.025	1000.0	-1000.0	0.002	-1000.0
Syndecan-1-mediated signaling events	22.0	776.0	34.0	-0.05	0.029	1000.0	-1000.0	-0.014	-1000.0
Glypican 1 network	22.0	1068.0	48.0	-0.038	0.042	1000.0	-1000.0	-0.023	-1000.0
Nectin adhesion pathway	22.0	1447.0	63.0	-0.092	0.043	1000.0	-1000.0	-0.027	-1000.0
TCGA08_retinoblastoma	22.0	182.0	8.0	-0.007	0.047	1000.0	-1000.0	-0.005	-1000.0
LPA receptor mediated events	21.0	2241.0	102.0	-0.076	0.032	1000.0	-1000.0	-0.063	-1000.0
EGFR-dependent Endothelin signaling events	21.0	446.0	21.0	-0.037	0.041	1000.0	-1000.0	-0.026	-1000.0
Osteopontin-mediated events	20.0	761.0	38.0	-0.047	0.032	1000.0	-1000.0	-0.016	-1000.0
Thromboxane A2 receptor signaling	20.0	2191.0	105.0	-0.087	0.034	1000.0	-1000.0	-0.025	-1000.0
p75(NTR)-mediated signaling	20.0	2550.0	125.0	-0.055	0.072	1000.0	-1000.0	-0.044	-1000.0
Signaling mediated by p38-alpha and p38-beta	20.0	889.0	44.0	-0.065	0.028	1000.0	-1000.0	-0.012	-1000.0
Integrins in angiogenesis	20.0	1742.0	84.0	-0.1	0.053	1000.0	-1000.0	-0.019	-1000.0
EPHB forward signaling	20.0	1705.0	85.0	-0.051	0.056	1000.0	-1000.0	-0.04	-1000.0
BMP receptor signaling	19.0	1581.0	81.0	-0.049	0.05	1000.0	-1000.0	-0.016	-1000.0
JNK signaling in the CD4+ TCR pathway	18.0	319.0	17.0	-0.088	0.04	1000.0	-1000.0	-0.017	-1000.0
Glucocorticoid receptor regulatory network	18.0	2115.0	114.0	-0.22	0.118	1000.0	-1000.0	-0.035	-1000.0
FAS signaling pathway (CD95)	18.0	867.0	47.0	-0.024	0.037	1000.0	-1000.0	-0.022	-1000.0
IL27-mediated signaling events	18.0	953.0	51.0	-0.161	0.098	1000.0	-1000.0	-0.042	-1000.0
Class IB PI3K non-lipid kinase events	18.0	54.0	3.0	-0.007	0.007	1000.0	-1000.0	-0.014	-1000.0
Caspase cascade in apoptosis	17.0	1298.0	74.0	-0.06	0.038	1000.0	-1000.0	-0.034	-1000.0
Noncanonical Wnt signaling pathway	17.0	467.0	26.0	-0.037	0.027	1000.0	-1000.0	-0.016	-1000.0
a4b1 and a4b7 Integrin signaling	17.0	89.0	5.0	0.002	0.019	1000.0	-1000.0	0.015	-1000.0
Arf6 signaling events	17.0	1063.0	62.0	-0.029	0.056	1000.0	-1000.0	-0.026	-1000.0
Glypican 2 network	17.0	71.0	4.0	0.011	0.014	1000.0	-1000.0	0.014	-1000.0
HIF-1-alpha transcription factor network	16.0	1291.0	76.0	-0.02	0.065	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by PTP1B	16.0	1226.0	76.0	-0.058	0.043	1000.0	-1000.0	-0.022	-1000.0
TRAIL signaling pathway	16.0	782.0	48.0	-0.035	0.041	1000.0	-1000.0	-0.024	-1000.0
Ephrin B reverse signaling	16.0	803.0	48.0	-0.049	0.039	1000.0	-1000.0	-0.033	-1000.0
Effects of Botulinum toxin	16.0	431.0	26.0	-0.017	0.041	1000.0	-1000.0	-0.01	-1000.0
Calcium signaling in the CD4+ TCR pathway	16.0	513.0	31.0	-0.078	0.029	1000.0	-1000.0	-0.024	-1000.0
Syndecan-4-mediated signaling events	16.0	1109.0	67.0	-0.046	0.038	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by the Hedgehog family	15.0	801.0	52.0	-0.029	0.045	1000.0	-1000.0	-0.019	-1000.0
Fc-epsilon receptor I signaling in mast cells	15.0	1503.0	97.0	-0.046	0.049	1000.0	-1000.0	-0.043	-1000.0
Ceramide signaling pathway	15.0	1202.0	76.0	-0.041	0.048	1000.0	-1000.0	-0.021	-1000.0
Reelin signaling pathway	15.0	859.0	56.0	-0.025	0.057	1000.0	-1000.0	-0.018	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	15.0	678.0	45.0	-0.042	0.057	1000.0	-1000.0	-0.037	-1000.0
Plasma membrane estrogen receptor signaling	15.0	1351.0	86.0	-0.115	0.082	1000.0	-1000.0	-0.029	-1000.0
S1P4 pathway	15.0	392.0	25.0	-0.031	0.036	1000.0	-1000.0	-0.014	-1000.0
amb2 Integrin signaling	14.0	1174.0	82.0	-0.035	0.047	1000.0	-1000.0	-0.015	-1000.0
S1P5 pathway	14.0	240.0	17.0	-0.026	0.034	1000.0	-1000.0	-0.004	-1000.0
IL2 signaling events mediated by PI3K	14.0	823.0	58.0	-0.09	0.042	1000.0	-1000.0	-0.02	-1000.0
Ras signaling in the CD4+ TCR pathway	14.0	247.0	17.0	-0.02	0.051	1000.0	-1000.0	-0.008	-1000.0
ErbB2/ErbB3 signaling events	13.0	876.0	65.0	-0.035	0.041	1000.0	-1000.0	-0.049	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	13.0	1177.0	85.0	-0.026	0.042	1000.0	-1000.0	-0.034	-1000.0
IFN-gamma pathway	13.0	899.0	68.0	-0.034	0.038	1000.0	-1000.0	-0.035	-1000.0
ceramide signaling pathway	13.0	644.0	49.0	-0.024	0.041	1000.0	-1000.0	-0.03	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	13.0	705.0	52.0	-0.051	0.059	1000.0	-1000.0	-0.017	-1000.0
Class I PI3K signaling events	13.0	1012.0	73.0	-0.097	0.051	1000.0	-1000.0	-0.025	-1000.0
TCGA08_p53	12.0	84.0	7.0	-0.012	0.024	1000.0	-1000.0	-0.009	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	12.0	1539.0	120.0	-0.07	0.07	1000.0	-1000.0	-0.024	-1000.0
Syndecan-2-mediated signaling events	11.0	782.0	69.0	-0.013	0.042	1000.0	-1000.0	-0.029	-1000.0
EPO signaling pathway	11.0	615.0	55.0	-0.009	0.048	1000.0	-1000.0	-0.015	-1000.0
LPA4-mediated signaling events	10.0	127.0	12.0	-0.039	0.0	1000.0	-1000.0	-0.016	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	10.0	568.0	54.0	-0.023	0.04	1000.0	-1000.0	-0.019	-1000.0
Cellular roles of Anthrax toxin	10.0	392.0	39.0	-0.029	0.028	1000.0	-1000.0	-0.014	-1000.0
PDGFR-alpha signaling pathway	10.0	447.0	44.0	-0.02	0.055	1000.0	-1000.0	-0.02	-1000.0
IL1-mediated signaling events	10.0	627.0	62.0	-0.026	0.074	1000.0	-1000.0	-0.02	-1000.0
S1P1 pathway	10.0	373.0	36.0	-0.059	0.028	1000.0	-1000.0	-0.03	-1000.0
Signaling mediated by p38-gamma and p38-delta	10.0	155.0	15.0	-0.018	0.027	1000.0	-1000.0	-0.02	-1000.0
IL2 signaling events mediated by STAT5	10.0	240.0	22.0	-0.037	0.029	1000.0	-1000.0	-0.024	-1000.0
PDGFR-beta signaling pathway	10.0	1062.0	97.0	-0.052	0.062	1000.0	-1000.0	-0.033	-1000.0
Regulation of Androgen receptor activity	10.0	752.0	70.0	-0.103	0.037	1000.0	-1000.0	-0.025	-1000.0
Regulation of nuclear SMAD2/3 signaling	9.0	1277.0	136.0	-0.295	0.071	1000.0	-1000.0	-0.031	-1000.0
Presenilin action in Notch and Wnt signaling	9.0	559.0	61.0	-0.011	0.073	1000.0	-1000.0	-0.032	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	9.0	345.0	37.0	-0.031	0.048	1000.0	-1000.0	-0.014	-1000.0
Paxillin-dependent events mediated by a4b1	9.0	342.0	36.0	-0.037	0.047	1000.0	-1000.0	-0.027	-1000.0
Canonical Wnt signaling pathway	9.0	475.0	51.0	-0.024	0.064	1000.0	-1000.0	-0.023	-1000.0
IGF1 pathway	9.0	529.0	57.0	-0.027	0.06	1000.0	-1000.0	-0.024	-1000.0
Sphingosine 1-phosphate (S1P) pathway	8.0	240.0	28.0	-0.026	0.044	1000.0	-1000.0	-0.017	-1000.0
FOXA2 and FOXA3 transcription factor networks	8.0	372.0	46.0	-0.153	0.038	1000.0	-1000.0	-0.058	-1000.0
Regulation of p38-alpha and p38-beta	8.0	456.0	54.0	-0.057	0.058	1000.0	-1000.0	-0.039	-1000.0
Nongenotropic Androgen signaling	8.0	460.0	52.0	-0.052	0.043	1000.0	-1000.0	-0.02	-1000.0
TCGA08_rtk_signaling	8.0	228.0	26.0	-0.021	0.061	1000.0	-1000.0	-0.009	-1000.0
S1P3 pathway	8.0	371.0	42.0	-0.026	0.045	1000.0	-1000.0	-0.021	-1000.0
Rapid glucocorticoid signaling	8.0	176.0	20.0	-0.012	0.028	1000.0	-1000.0	-0.009	-1000.0
ErbB4 signaling events	7.0	493.0	69.0	-0.069	0.064	1000.0	-1000.0	-0.022	-1000.0
mTOR signaling pathway	7.0	379.0	53.0	-0.035	0.033	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class III	7.0	303.0	40.0	-0.055	0.046	1000.0	-1000.0	-0.038	-1000.0
HIF-2-alpha transcription factor network	7.0	309.0	43.0	-0.106	0.108	1000.0	-1000.0	-0.032	-1000.0
Retinoic acid receptors-mediated signaling	7.0	438.0	58.0	-0.038	0.055	1000.0	-1000.0	-0.025	-1000.0
Atypical NF-kappaB pathway	7.0	229.0	31.0	-0.014	0.036	1000.0	-1000.0	-0.019	-1000.0
Insulin Pathway	7.0	572.0	74.0	-0.082	0.07	1000.0	-1000.0	-0.028	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	7.0	238.0	33.0	-0.003	0.061	1000.0	-1000.0	-0.017	-1000.0
Visual signal transduction: Rods	7.0	411.0	52.0	-0.012	0.048	1000.0	-1000.0	-0.011	-1000.0
Coregulation of Androgen receptor activity	6.0	509.0	76.0	-0.071	0.048	1000.0	-1000.0	-0.016	-1000.0
Hedgehog signaling events mediated by Gli proteins	6.0	446.0	65.0	-0.045	0.067	1000.0	-1000.0	-0.033	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	6.0	524.0	83.0	-0.033	0.054	1000.0	-1000.0	-0.009	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	6.0	838.0	125.0	-0.013	0.067	1000.0	-1000.0	-0.019	-1000.0
IL6-mediated signaling events	6.0	499.0	75.0	-0.035	0.085	1000.0	-1000.0	-0.042	-1000.0
Regulation of Telomerase	6.0	640.0	102.0	-0.087	0.057	1000.0	-1000.0	-0.028	-1000.0
FOXM1 transcription factor network	6.0	350.0	51.0	-0.02	0.082	1000.0	-1000.0	-0.073	-1000.0
Aurora B signaling	6.0	428.0	67.0	-0.065	0.063	1000.0	-1000.0	-0.025	-1000.0
PLK2 and PLK4 events	5.0	16.0	3.0	-0.019	-1000.0	1000.0	-1000.0	-0.016	-1000.0
Visual signal transduction: Cones	5.0	192.0	38.0	-0.016	0.052	1000.0	-1000.0	-0.018	-1000.0
Arf6 downstream pathway	5.0	234.0	43.0	-0.039	0.049	1000.0	-1000.0	-0.029	-1000.0
Syndecan-3-mediated signaling events	5.0	196.0	35.0	-0.0	0.072	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by PRL	5.0	192.0	34.0	-0.023	0.046	1000.0	-1000.0	-0.027	-1000.0
p38 MAPK signaling pathway	5.0	222.0	44.0	-0.043	0.046	1000.0	-1000.0	-0.009	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	4.0	141.0	34.0	-0.043	0.073	1000.0	-1000.0	-0.026	-1000.0
Canonical NF-kappaB pathway	4.0	176.0	39.0	-0.008	0.059	1000.0	-1000.0	-0.013	-1000.0
BARD1 signaling events	4.0	239.0	57.0	-0.054	0.061	1000.0	-1000.0	-0.044	-1000.0
PLK1 signaling events	4.0	377.0	85.0	-0.007	0.051	1000.0	-1000.0	-0.018	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	301.0	68.0	-0.038	0.052	1000.0	-1000.0	-0.019	-1000.0
FoxO family signaling	4.0	310.0	64.0	-0.175	0.042	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by HDAC Class I	3.0	353.0	104.0	-0.053	0.067	1000.0	-1000.0	-0.033	-1000.0
VEGFR1 specific signals	3.0	212.0	56.0	-0.032	0.054	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class II	2.0	154.0	75.0	-0.029	0.07	1000.0	-1000.0	-0.019	-1000.0
Circadian rhythm pathway	2.0	44.0	22.0	-0.007	0.044	1000.0	-1000.0	-0.02	-1000.0
Aurora A signaling	2.0	175.0	60.0	-0.026	0.059	1000.0	-1000.0	-0.017	-1000.0
Aurora C signaling	2.0	17.0	7.0	-0.0	0.046	1000.0	-1000.0	-0.006	-1000.0
Insulin-mediated glucose transport	2.0	77.0	32.0	-0.022	0.051	1000.0	-1000.0	-0.018	-1000.0
Arf6 trafficking events	2.0	187.0	71.0	-0.041	0.052	1000.0	-1000.0	-0.034	-1000.0
Arf1 pathway	1.0	102.0	54.0	-0.006	0.047	1000.0	-1000.0	-0.009	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	15.0	23.0	0.005	0.056	1000.0	-1000.0	-0.013	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	8.0	27.0	-0.012	0.067	1000.0	-1000.0	-0.023	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	-0.0	0.072	1000.0	-1000.0	-0.0	-1000.0
Total	1742	103713	7203	-7.84038979942	-993.203126307	131000	-131000	-3.1701825474	-131000