(primary solid tumor cohort)
This pipeline computes the correlation between significant arm-level copy number variations (cnvs) and subtypes.
Testing the association between copy number variation 77 arm-level results and 6 molecular subtypes across 306 patients, 62 significant findings detected with Q value < 0.25.
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1p gain cnv correlated to 'CN_CNMF'.
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1q gain cnv correlated to 'CN_CNMF'.
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2p gain cnv correlated to 'CN_CNMF'.
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2q gain cnv correlated to 'CN_CNMF'.
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5p gain cnv correlated to 'CN_CNMF'.
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6p gain cnv correlated to 'CN_CNMF'.
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6q gain cnv correlated to 'CN_CNMF'.
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7p gain cnv correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
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7q gain cnv correlated to 'CN_CNMF'.
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8p gain cnv correlated to 'CN_CNMF'.
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8q gain cnv correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
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10p gain cnv correlated to 'CN_CNMF'.
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10q gain cnv correlated to 'CN_CNMF'.
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13q gain cnv correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
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16p gain cnv correlated to 'CN_CNMF'.
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20p gain cnv correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
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20q gain cnv correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
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1p loss cnv correlated to 'CN_CNMF'.
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3p loss cnv correlated to 'CN_CNMF'.
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3q loss cnv correlated to 'CN_CNMF' and 'MIRSEQ_CNMF'.
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4p loss cnv correlated to 'CN_CNMF' and 'MIRSEQ_CHIERARCHICAL'.
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4q loss cnv correlated to 'CN_CNMF', 'METHLYATION_CNMF', and 'MIRSEQ_CHIERARCHICAL'.
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5p loss cnv correlated to 'CN_CNMF'.
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5q loss cnv correlated to 'CN_CNMF' and 'MIRSEQ_CHIERARCHICAL'.
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7q loss cnv correlated to 'CN_CNMF'.
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8p loss cnv correlated to 'CN_CNMF'.
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9p loss cnv correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
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9q loss cnv correlated to 'CN_CNMF'.
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10p loss cnv correlated to 'CN_CNMF'.
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10q loss cnv correlated to 'CN_CNMF'.
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11p loss cnv correlated to 'CN_CNMF'.
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11q loss cnv correlated to 'CN_CNMF'.
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12p loss cnv correlated to 'CN_CNMF'.
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13q loss cnv correlated to 'CN_CNMF'.
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14q loss cnv correlated to 'CN_CNMF'.
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15q loss cnv correlated to 'CN_CNMF'.
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16p loss cnv correlated to 'CN_CNMF'.
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16q loss cnv correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
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17p loss cnv correlated to 'CN_CNMF', 'METHLYATION_CNMF', and 'MIRSEQ_CHIERARCHICAL'.
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17q loss cnv correlated to 'CN_CNMF'.
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18q loss cnv correlated to 'CN_CNMF'.
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19p loss cnv correlated to 'CN_CNMF'.
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19q loss cnv correlated to 'CN_CNMF'.
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20p loss cnv correlated to 'CN_CNMF'.
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21q loss cnv correlated to 'CN_CNMF'.
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22q loss cnv correlated to 'CN_CNMF', 'METHLYATION_CNMF', and 'MIRSEQ_CNMF'.
Molecular subtypes |
CN CNMF |
METHLYATION CNMF |
MRNASEQ CNMF |
MRNASEQ CHIERARCHICAL |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
||
nCNV (%) | nWild-Type | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | |
4q loss | 47 (15%) | 259 |
1.17e-14 (4.94e-12) |
0.000173 (0.0653) |
0.664 (1.00) |
0.55 (1.00) |
0.00291 (0.991) |
1.56e-07 (6.32e-05) |
17p loss | 58 (19%) | 248 |
3.45e-18 (1.47e-15) |
0.000157 (0.0597) |
0.281 (1.00) |
0.0973 (1.00) |
0.00285 (0.975) |
0.00067 (0.247) |
22q loss | 39 (13%) | 267 |
9.26e-17 (3.93e-14) |
8.17e-06 (0.00327) |
0.664 (1.00) |
1 (1.00) |
0.000238 (0.0894) |
0.000908 (0.33) |
7p gain | 89 (29%) | 217 |
1.21e-18 (5.19e-16) |
0.000148 (0.0564) |
1 (1.00) |
0.523 (1.00) |
0.00664 (1.00) |
0.0132 (1.00) |
8q gain | 108 (35%) | 198 |
4.09e-05 (0.0158) |
1.52e-05 (0.00598) |
0.364 (1.00) |
0.779 (1.00) |
0.00768 (1.00) |
0.116 (1.00) |
13q gain | 62 (20%) | 244 |
2.58e-08 (1.07e-05) |
0.000677 (0.249) |
0.721 (1.00) |
0.885 (1.00) |
0.399 (1.00) |
0.135 (1.00) |
20p gain | 122 (40%) | 184 |
2.71e-19 (1.16e-16) |
7.9e-05 (0.0302) |
0.129 (1.00) |
0.0165 (1.00) |
0.17 (1.00) |
0.0174 (1.00) |
20q gain | 149 (49%) | 157 |
2.59e-29 (1.11e-26) |
4.18e-08 (1.71e-05) |
0.227 (1.00) |
0.0227 (1.00) |
0.00809 (1.00) |
0.00118 (0.429) |
3q loss | 15 (5%) | 291 |
9.73e-06 (0.00384) |
0.0174 (1.00) |
0.233 (1.00) |
0.000629 (0.234) |
0.0137 (1.00) |
|
4p loss | 49 (16%) | 257 |
7.25e-11 (3.02e-08) |
0.000706 (0.259) |
0.457 (1.00) |
0.674 (1.00) |
0.00646 (1.00) |
2.88e-07 (0.000116) |
5q loss | 34 (11%) | 272 |
2.59e-12 (1.09e-09) |
0.00166 (0.593) |
1 (1.00) |
1 (1.00) |
0.0289 (1.00) |
0.000219 (0.0822) |
9p loss | 47 (15%) | 259 |
4.54e-17 (1.93e-14) |
0.000291 (0.109) |
0.698 (1.00) |
0.863 (1.00) |
0.00646 (1.00) |
0.00453 (1.00) |
16q loss | 26 (8%) | 280 |
7.49e-10 (3.1e-07) |
0.000502 (0.187) |
1 (1.00) |
0.349 (1.00) |
0.0386 (1.00) |
0.215 (1.00) |
1p gain | 15 (5%) | 291 |
3.44e-05 (0.0134) |
0.924 (1.00) |
1 (1.00) |
0.643 (1.00) |
0.627 (1.00) |
0.926 (1.00) |
1q gain | 41 (13%) | 265 |
2.96e-11 (1.24e-08) |
0.00499 (1.00) |
1 (1.00) |
0.73 (1.00) |
0.00209 (0.732) |
0.0318 (1.00) |
2p gain | 21 (7%) | 285 |
4.42e-06 (0.00177) |
0.00225 (0.782) |
0.488 (1.00) |
0.23 (1.00) |
0.00766 (1.00) |
|
2q gain | 22 (7%) | 284 |
6.4e-05 (0.0246) |
0.00225 (0.782) |
0.233 (1.00) |
0.268 (1.00) |
0.436 (1.00) |
0.067 (1.00) |
5p gain | 36 (12%) | 270 |
8.5e-08 (3.47e-05) |
0.0208 (1.00) |
0.281 (1.00) |
0.464 (1.00) |
0.106 (1.00) |
0.117 (1.00) |
6p gain | 23 (8%) | 283 |
1.57e-05 (0.00619) |
0.0041 (1.00) |
1 (1.00) |
1 (1.00) |
0.00644 (1.00) |
0.257 (1.00) |
6q gain | 20 (7%) | 286 |
5.05e-05 (0.0194) |
0.00235 (0.813) |
1 (1.00) |
1 (1.00) |
0.0159 (1.00) |
0.139 (1.00) |
7q gain | 72 (24%) | 234 |
1.59e-16 (6.72e-14) |
0.00384 (1.00) |
1 (1.00) |
1 (1.00) |
0.0156 (1.00) |
0.226 (1.00) |
8p gain | 81 (26%) | 225 |
4.12e-05 (0.0159) |
0.00238 (0.821) |
0.543 (1.00) |
0.84 (1.00) |
0.0121 (1.00) |
0.657 (1.00) |
10p gain | 42 (14%) | 264 |
3.14e-10 (1.3e-07) |
0.0017 (0.604) |
0.412 (1.00) |
0.557 (1.00) |
0.723 (1.00) |
0.0594 (1.00) |
10q gain | 25 (8%) | 281 |
8.66e-06 (0.00344) |
0.0622 (1.00) |
0.607 (1.00) |
0.643 (1.00) |
0.316 (1.00) |
0.692 (1.00) |
16p gain | 14 (5%) | 292 |
0.000637 (0.236) |
0.0569 (1.00) |
0.607 (1.00) |
0.643 (1.00) |
0.618 (1.00) |
0.251 (1.00) |
1p loss | 14 (5%) | 292 |
4.12e-06 (0.00166) |
0.543 (1.00) |
0.488 (1.00) |
0.131 (1.00) |
1 (1.00) |
|
3p loss | 26 (8%) | 280 |
4.42e-08 (1.81e-05) |
0.00759 (1.00) |
0.233 (1.00) |
0.00362 (1.00) |
0.0155 (1.00) |
|
5p loss | 15 (5%) | 291 |
1.67e-05 (0.00654) |
0.0979 (1.00) |
0.488 (1.00) |
0.848 (1.00) |
0.199 (1.00) |
|
7q loss | 12 (4%) | 294 |
2.9e-05 (0.0113) |
0.0674 (1.00) |
0.233 (1.00) |
0.0179 (1.00) |
0.0179 (1.00) |
|
8p loss | 27 (9%) | 279 |
1.19e-06 (0.000481) |
0.121 (1.00) |
0.664 (1.00) |
0.73 (1.00) |
0.0142 (1.00) |
0.0301 (1.00) |
9q loss | 25 (8%) | 281 |
3.15e-08 (1.3e-05) |
0.00141 (0.506) |
1 (1.00) |
0.163 (1.00) |
0.0301 (1.00) |
|
10p loss | 17 (6%) | 289 |
0.000108 (0.0412) |
0.0103 (1.00) |
1 (1.00) |
0.203 (1.00) |
0.343 (1.00) |
0.337 (1.00) |
10q loss | 17 (6%) | 289 |
8.39e-06 (0.00335) |
0.00576 (1.00) |
0.345 (1.00) |
0.481 (1.00) |
0.24 (1.00) |
0.209 (1.00) |
11p loss | 19 (6%) | 287 |
1.63e-05 (0.00638) |
0.00172 (0.611) |
1 (1.00) |
0.0974 (1.00) |
0.059 (1.00) |
0.106 (1.00) |
11q loss | 17 (6%) | 289 |
9.49e-06 (0.00376) |
0.00503 (1.00) |
1 (1.00) |
0.387 (1.00) |
0.0689 (1.00) |
0.32 (1.00) |
12p loss | 19 (6%) | 287 |
0.00014 (0.0534) |
0.00784 (1.00) |
0.108 (1.00) |
0.0284 (1.00) |
0.24 (1.00) |
0.0907 (1.00) |
13q loss | 9 (3%) | 297 |
0.000419 (0.156) |
0.225 (1.00) |
0.488 (1.00) |
0.389 (1.00) |
0.486 (1.00) |
|
14q loss | 25 (8%) | 281 |
8.66e-06 (0.00344) |
0.0622 (1.00) |
0.345 (1.00) |
0.481 (1.00) |
0.0535 (1.00) |
0.0677 (1.00) |
15q loss | 22 (7%) | 284 |
1.09e-07 (4.42e-05) |
0.00666 (1.00) |
0.607 (1.00) |
0.745 (1.00) |
0.571 (1.00) |
0.114 (1.00) |
16p loss | 24 (8%) | 282 |
1.01e-10 (4.18e-08) |
0.00734 (1.00) |
1 (1.00) |
1 (1.00) |
0.115 (1.00) |
0.32 (1.00) |
17q loss | 19 (6%) | 287 |
2.17e-05 (0.00845) |
0.323 (1.00) |
0.664 (1.00) |
1 (1.00) |
0.0491 (1.00) |
0.00713 (1.00) |
18q loss | 51 (17%) | 255 |
1.13e-07 (4.6e-05) |
0.0306 (1.00) |
0.736 (1.00) |
1 (1.00) |
0.127 (1.00) |
0.187 (1.00) |
19p loss | 30 (10%) | 276 |
1.87e-12 (7.88e-10) |
0.0122 (1.00) |
0.0089 (1.00) |
0.0106 (1.00) |
0.219 (1.00) |
0.00203 (0.711) |
19q loss | 21 (7%) | 285 |
3.32e-08 (1.37e-05) |
0.00548 (1.00) |
0.0211 (1.00) |
0.0358 (1.00) |
0.101 (1.00) |
0.00326 (1.00) |
20p loss | 10 (3%) | 296 |
0.000171 (0.0645) |
0.00222 (0.776) |
0.488 (1.00) |
0.374 (1.00) |
1 (1.00) |
|
21q loss | 53 (17%) | 253 |
1.73e-11 (7.25e-09) |
0.0209 (1.00) |
0.281 (1.00) |
0.0973 (1.00) |
0.00354 (1.00) |
0.452 (1.00) |
3p gain | 9 (3%) | 297 |
0.433 (1.00) |
0.225 (1.00) |
0.488 (1.00) |
0.365 (1.00) |
0.577 (1.00) |
|
3q gain | 26 (8%) | 280 |
0.00134 (0.482) |
0.256 (1.00) |
0.0211 (1.00) |
0.117 (1.00) |
0.453 (1.00) |
0.149 (1.00) |
4p gain | 5 (2%) | 301 |
0.0396 (1.00) |
0.286 (1.00) |
1 (1.00) |
0.837 (1.00) |
0.689 (1.00) |
|
5q gain | 9 (3%) | 297 |
0.00202 (0.71) |
1 (1.00) |
0.108 (1.00) |
0.101 (1.00) |
0.2 (1.00) |
0.535 (1.00) |
9p gain | 20 (7%) | 286 |
0.14 (1.00) |
0.493 (1.00) |
0.345 (1.00) |
0.481 (1.00) |
0.94 (1.00) |
0.359 (1.00) |
9q gain | 25 (8%) | 281 |
0.0146 (1.00) |
0.471 (1.00) |
0.185 (1.00) |
0.219 (1.00) |
0.74 (1.00) |
0.638 (1.00) |
11p gain | 11 (4%) | 295 |
0.511 (1.00) |
0.112 (1.00) |
1 (1.00) |
0.7 (1.00) |
0.548 (1.00) |
|
11q gain | 18 (6%) | 288 |
0.101 (1.00) |
0.03 (1.00) |
0.488 (1.00) |
0.266 (1.00) |
0.822 (1.00) |
|
12p gain | 30 (10%) | 276 |
0.00259 (0.891) |
0.0664 (1.00) |
0.233 (1.00) |
0.268 (1.00) |
0.108 (1.00) |
0.759 (1.00) |
12q gain | 23 (8%) | 283 |
0.296 (1.00) |
0.279 (1.00) |
0.108 (1.00) |
0.279 (1.00) |
0.24 (1.00) |
0.359 (1.00) |
14q gain | 4 (1%) | 302 |
0.0834 (1.00) |
0.776 (1.00) |
1 (1.00) |
|||
15q gain | 10 (3%) | 296 |
0.0159 (1.00) |
0.274 (1.00) |
0.7 (1.00) |
0.0527 (1.00) |
||
16q gain | 11 (4%) | 295 |
0.00147 (0.526) |
0.87 (1.00) |
0.607 (1.00) |
0.643 (1.00) |
0.848 (1.00) |
0.123 (1.00) |
17p gain | 7 (2%) | 299 |
0.0109 (1.00) |
0.803 (1.00) |
1 (1.00) |
0.346 (1.00) |
1 (1.00) |
|
17q gain | 13 (4%) | 293 |
0.00272 (0.934) |
0.976 (1.00) |
1 (1.00) |
0.0906 (1.00) |
0.792 (1.00) |
|
18p gain | 21 (7%) | 285 |
0.00376 (1.00) |
0.000849 (0.31) |
0.664 (1.00) |
0.84 (1.00) |
0.0303 (1.00) |
0.777 (1.00) |
18q gain | 13 (4%) | 293 |
0.0558 (1.00) |
0.0934 (1.00) |
0.607 (1.00) |
1 (1.00) |
0.0701 (1.00) |
0.132 (1.00) |
19p gain | 12 (4%) | 294 |
0.362 (1.00) |
0.0797 (1.00) |
0.345 (1.00) |
0.356 (1.00) |
0.066 (1.00) |
0.264 (1.00) |
19q gain | 28 (9%) | 278 |
0.0159 (1.00) |
0.1 (1.00) |
0.412 (1.00) |
0.23 (1.00) |
0.592 (1.00) |
0.453 (1.00) |
22q gain | 6 (2%) | 300 |
0.0199 (1.00) |
0.19 (1.00) |
0.453 (1.00) |
0.369 (1.00) |
||
Xq gain | 4 (1%) | 302 |
0.0834 (1.00) |
0.123 (1.00) |
1 (1.00) |
|||
1q loss | 4 (1%) | 302 |
0.0573 (1.00) |
0.75 (1.00) |
0.227 (1.00) |
0.689 (1.00) |
||
2p loss | 4 (1%) | 302 |
0.0573 (1.00) |
0.542 (1.00) |
1 (1.00) |
1 (1.00) |
0.173 (1.00) |
|
2q loss | 5 (2%) | 301 |
0.0272 (1.00) |
0.223 (1.00) |
1 (1.00) |
1 (1.00) |
0.087 (1.00) |
|
6p loss | 14 (5%) | 292 |
0.00607 (1.00) |
0.552 (1.00) |
0.488 (1.00) |
0.191 (1.00) |
0.254 (1.00) |
|
6q loss | 18 (6%) | 288 |
0.00198 (0.699) |
0.272 (1.00) |
0.607 (1.00) |
0.0105 (1.00) |
0.431 (1.00) |
0.405 (1.00) |
7p loss | 5 (2%) | 301 |
0.0272 (1.00) |
0.861 (1.00) |
0.233 (1.00) |
0.453 (1.00) |
0.283 (1.00) |
|
8q loss | 8 (3%) | 298 |
0.0013 (0.469) |
0.337 (1.00) |
1 (1.00) |
0.513 (1.00) |
0.0559 (1.00) |
|
12q loss | 11 (4%) | 295 |
0.00593 (1.00) |
0.00147 (0.525) |
0.233 (1.00) |
0.374 (1.00) |
0.0561 (1.00) |
|
18p loss | 36 (12%) | 270 |
0.000781 (0.286) |
0.102 (1.00) |
0.698 (1.00) |
0.863 (1.00) |
0.219 (1.00) |
0.126 (1.00) |
Xq loss | 13 (4%) | 293 |
0.00107 (0.388) |
0.0516 (1.00) |
0.607 (1.00) |
0.745 (1.00) |
0.257 (1.00) |
0.383 (1.00) |
P value = 3.44e-05 (Fisher's exact test), Q value = 0.013
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
1P GAIN MUTATED | 0 | 11 | 4 |
1P GAIN WILD-TYPE | 153 | 107 | 31 |
P value = 2.96e-11 (Fisher's exact test), Q value = 1.2e-08
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
1Q GAIN MUTATED | 2 | 27 | 12 |
1Q GAIN WILD-TYPE | 151 | 91 | 23 |
P value = 4.42e-06 (Fisher's exact test), Q value = 0.0018
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
2P GAIN MUTATED | 1 | 13 | 7 |
2P GAIN WILD-TYPE | 152 | 105 | 28 |
P value = 6.4e-05 (Fisher's exact test), Q value = 0.025
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
2Q GAIN MUTATED | 2 | 14 | 6 |
2Q GAIN WILD-TYPE | 151 | 104 | 29 |
P value = 8.5e-08 (Fisher's exact test), Q value = 3.5e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
5P GAIN MUTATED | 4 | 29 | 3 |
5P GAIN WILD-TYPE | 149 | 89 | 32 |
P value = 1.57e-05 (Fisher's exact test), Q value = 0.0062
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
6P GAIN MUTATED | 2 | 19 | 2 |
6P GAIN WILD-TYPE | 151 | 99 | 33 |
P value = 5.05e-05 (Fisher's exact test), Q value = 0.019
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
6Q GAIN MUTATED | 2 | 17 | 1 |
6Q GAIN WILD-TYPE | 151 | 101 | 34 |
P value = 1.21e-18 (Fisher's exact test), Q value = 5.2e-16
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
7P GAIN MUTATED | 13 | 49 | 27 |
7P GAIN WILD-TYPE | 140 | 69 | 8 |
P value = 0.000148 (Fisher's exact test), Q value = 0.056
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 37 | 79 | 64 | 78 |
7P GAIN MUTATED | 8 | 24 | 7 | 34 |
7P GAIN WILD-TYPE | 29 | 55 | 57 | 44 |
P value = 1.59e-16 (Fisher's exact test), Q value = 6.7e-14
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
7Q GAIN MUTATED | 12 | 33 | 27 |
7Q GAIN WILD-TYPE | 141 | 85 | 8 |
P value = 4.12e-05 (Fisher's exact test), Q value = 0.016
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
8P GAIN MUTATED | 33 | 27 | 21 |
8P GAIN WILD-TYPE | 120 | 91 | 14 |
P value = 4.09e-05 (Fisher's exact test), Q value = 0.016
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
8Q GAIN MUTATED | 37 | 50 | 21 |
8Q GAIN WILD-TYPE | 116 | 68 | 14 |
P value = 1.52e-05 (Fisher's exact test), Q value = 0.006
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 37 | 79 | 64 | 78 |
8Q GAIN MUTATED | 12 | 30 | 6 | 35 |
8Q GAIN WILD-TYPE | 25 | 49 | 58 | 43 |
P value = 3.14e-10 (Fisher's exact test), Q value = 1.3e-07
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
10P GAIN MUTATED | 3 | 33 | 6 |
10P GAIN WILD-TYPE | 150 | 85 | 29 |
P value = 8.66e-06 (Fisher's exact test), Q value = 0.0034
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
10Q GAIN MUTATED | 3 | 21 | 1 |
10Q GAIN WILD-TYPE | 150 | 97 | 34 |
P value = 2.58e-08 (Fisher's exact test), Q value = 1.1e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
13Q GAIN MUTATED | 12 | 34 | 16 |
13Q GAIN WILD-TYPE | 141 | 84 | 19 |
P value = 0.000677 (Fisher's exact test), Q value = 0.25
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 37 | 79 | 64 | 78 |
13Q GAIN MUTATED | 5 | 15 | 5 | 27 |
13Q GAIN WILD-TYPE | 32 | 64 | 59 | 51 |
P value = 0.000637 (Fisher's exact test), Q value = 0.24
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
16P GAIN MUTATED | 1 | 12 | 1 |
16P GAIN WILD-TYPE | 152 | 106 | 34 |
P value = 2.71e-19 (Fisher's exact test), Q value = 1.2e-16
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
20P GAIN MUTATED | 25 | 67 | 30 |
20P GAIN WILD-TYPE | 128 | 51 | 5 |
P value = 7.9e-05 (Fisher's exact test), Q value = 0.03
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 37 | 79 | 64 | 78 |
20P GAIN MUTATED | 18 | 29 | 11 | 41 |
20P GAIN WILD-TYPE | 19 | 50 | 53 | 37 |
P value = 2.59e-29 (Fisher's exact test), Q value = 1.1e-26
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
20Q GAIN MUTATED | 27 | 90 | 32 |
20Q GAIN WILD-TYPE | 126 | 28 | 3 |
P value = 4.18e-08 (Fisher's exact test), Q value = 1.7e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 37 | 79 | 64 | 78 |
20Q GAIN MUTATED | 19 | 38 | 13 | 55 |
20Q GAIN WILD-TYPE | 18 | 41 | 51 | 23 |
P value = 4.12e-06 (Fisher's exact test), Q value = 0.0017
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
1P LOSS MUTATED | 0 | 14 | 0 |
1P LOSS WILD-TYPE | 153 | 104 | 35 |
P value = 4.42e-08 (Fisher's exact test), Q value = 1.8e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
3P LOSS MUTATED | 1 | 23 | 2 |
3P LOSS WILD-TYPE | 152 | 95 | 33 |
P value = 9.73e-06 (Fisher's exact test), Q value = 0.0038
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
3Q LOSS MUTATED | 0 | 14 | 1 |
3Q LOSS WILD-TYPE | 153 | 104 | 34 |
P value = 0.000629 (Fisher's exact test), Q value = 0.23
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 89 | 55 | 92 |
3Q LOSS MUTATED | 0 | 0 | 9 |
3Q LOSS WILD-TYPE | 89 | 55 | 83 |
P value = 7.25e-11 (Fisher's exact test), Q value = 3e-08
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
4P LOSS MUTATED | 5 | 39 | 5 |
4P LOSS WILD-TYPE | 148 | 79 | 30 |
P value = 2.88e-07 (Fisher's exact test), Q value = 0.00012
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 59 | 104 | 73 |
4P LOSS MUTATED | 23 | 8 | 5 |
4P LOSS WILD-TYPE | 36 | 96 | 68 |
P value = 1.17e-14 (Fisher's exact test), Q value = 4.9e-12
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
4Q LOSS MUTATED | 2 | 41 | 4 |
4Q LOSS WILD-TYPE | 151 | 77 | 31 |
P value = 0.000173 (Fisher's exact test), Q value = 0.065
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 37 | 79 | 64 | 78 |
4Q LOSS MUTATED | 0 | 14 | 6 | 22 |
4Q LOSS WILD-TYPE | 37 | 65 | 58 | 56 |
P value = 1.56e-07 (Fisher's exact test), Q value = 6.3e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 59 | 104 | 73 |
4Q LOSS MUTATED | 22 | 7 | 4 |
4Q LOSS WILD-TYPE | 37 | 97 | 69 |
P value = 1.67e-05 (Fisher's exact test), Q value = 0.0065
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
5P LOSS MUTATED | 0 | 13 | 2 |
5P LOSS WILD-TYPE | 153 | 105 | 33 |
P value = 2.59e-12 (Fisher's exact test), Q value = 1.1e-09
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
5Q LOSS MUTATED | 0 | 30 | 4 |
5Q LOSS WILD-TYPE | 153 | 88 | 31 |
P value = 0.000219 (Fisher's exact test), Q value = 0.082
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 59 | 104 | 73 |
5Q LOSS MUTATED | 14 | 7 | 2 |
5Q LOSS WILD-TYPE | 45 | 97 | 71 |
P value = 2.9e-05 (Fisher's exact test), Q value = 0.011
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
7Q LOSS MUTATED | 0 | 12 | 0 |
7Q LOSS WILD-TYPE | 153 | 106 | 35 |
P value = 1.19e-06 (Fisher's exact test), Q value = 0.00048
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
8P LOSS MUTATED | 3 | 23 | 1 |
8P LOSS WILD-TYPE | 150 | 95 | 34 |
P value = 4.54e-17 (Fisher's exact test), Q value = 1.9e-14
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
9P LOSS MUTATED | 2 | 44 | 1 |
9P LOSS WILD-TYPE | 151 | 74 | 34 |
P value = 0.000291 (Fisher's exact test), Q value = 0.11
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 37 | 79 | 64 | 78 |
9P LOSS MUTATED | 1 | 11 | 5 | 23 |
9P LOSS WILD-TYPE | 36 | 68 | 59 | 55 |
P value = 3.15e-08 (Fisher's exact test), Q value = 1.3e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
9Q LOSS MUTATED | 1 | 23 | 1 |
9Q LOSS WILD-TYPE | 152 | 95 | 34 |
P value = 0.000108 (Fisher's exact test), Q value = 0.041
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
10P LOSS MUTATED | 1 | 14 | 2 |
10P LOSS WILD-TYPE | 152 | 104 | 33 |
P value = 8.39e-06 (Fisher's exact test), Q value = 0.0033
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
10Q LOSS MUTATED | 0 | 14 | 3 |
10Q LOSS WILD-TYPE | 153 | 104 | 32 |
P value = 1.63e-05 (Fisher's exact test), Q value = 0.0064
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
11P LOSS MUTATED | 2 | 17 | 0 |
11P LOSS WILD-TYPE | 151 | 101 | 35 |
P value = 9.49e-06 (Fisher's exact test), Q value = 0.0038
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
11Q LOSS MUTATED | 1 | 16 | 0 |
11Q LOSS WILD-TYPE | 152 | 102 | 35 |
P value = 0.00014 (Fisher's exact test), Q value = 0.053
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
12P LOSS MUTATED | 2 | 16 | 1 |
12P LOSS WILD-TYPE | 151 | 102 | 34 |
P value = 0.000419 (Fisher's exact test), Q value = 0.16
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
13Q LOSS MUTATED | 0 | 9 | 0 |
13Q LOSS WILD-TYPE | 153 | 109 | 35 |
P value = 8.66e-06 (Fisher's exact test), Q value = 0.0034
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
14Q LOSS MUTATED | 3 | 21 | 1 |
14Q LOSS WILD-TYPE | 150 | 97 | 34 |
P value = 1.09e-07 (Fisher's exact test), Q value = 4.4e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
15Q LOSS MUTATED | 0 | 19 | 3 |
15Q LOSS WILD-TYPE | 153 | 99 | 32 |
P value = 1.01e-10 (Fisher's exact test), Q value = 4.2e-08
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
16P LOSS MUTATED | 0 | 24 | 0 |
16P LOSS WILD-TYPE | 153 | 94 | 35 |
P value = 7.49e-10 (Fisher's exact test), Q value = 3.1e-07
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
16Q LOSS MUTATED | 1 | 25 | 0 |
16Q LOSS WILD-TYPE | 152 | 93 | 35 |
P value = 0.000502 (Fisher's exact test), Q value = 0.19
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 37 | 79 | 64 | 78 |
16Q LOSS MUTATED | 0 | 5 | 1 | 14 |
16Q LOSS WILD-TYPE | 37 | 74 | 63 | 64 |
P value = 3.45e-18 (Fisher's exact test), Q value = 1.5e-15
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
17P LOSS MUTATED | 2 | 49 | 7 |
17P LOSS WILD-TYPE | 151 | 69 | 28 |
P value = 0.000157 (Fisher's exact test), Q value = 0.06
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 37 | 79 | 64 | 78 |
17P LOSS MUTATED | 3 | 13 | 5 | 27 |
17P LOSS WILD-TYPE | 34 | 66 | 59 | 51 |
P value = 0.00067 (Fisher's exact test), Q value = 0.25
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 59 | 104 | 73 |
17P LOSS MUTATED | 21 | 16 | 7 |
17P LOSS WILD-TYPE | 38 | 88 | 66 |
P value = 2.17e-05 (Fisher's exact test), Q value = 0.0084
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
17Q LOSS MUTATED | 1 | 16 | 2 |
17Q LOSS WILD-TYPE | 152 | 102 | 33 |
P value = 1.13e-07 (Fisher's exact test), Q value = 4.6e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
18Q LOSS MUTATED | 9 | 37 | 5 |
18Q LOSS WILD-TYPE | 144 | 81 | 30 |
P value = 1.87e-12 (Fisher's exact test), Q value = 7.9e-10
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
19P LOSS MUTATED | 0 | 29 | 1 |
19P LOSS WILD-TYPE | 153 | 89 | 34 |
P value = 3.32e-08 (Fisher's exact test), Q value = 1.4e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
19Q LOSS MUTATED | 0 | 20 | 1 |
19Q LOSS WILD-TYPE | 153 | 98 | 34 |
P value = 0.000171 (Fisher's exact test), Q value = 0.064
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
20P LOSS MUTATED | 0 | 10 | 0 |
20P LOSS WILD-TYPE | 153 | 108 | 35 |
P value = 1.73e-11 (Fisher's exact test), Q value = 7.2e-09
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
21Q LOSS MUTATED | 5 | 40 | 8 |
21Q LOSS WILD-TYPE | 148 | 78 | 27 |
P value = 9.26e-17 (Fisher's exact test), Q value = 3.9e-14
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 118 | 35 |
22Q LOSS MUTATED | 0 | 38 | 1 |
22Q LOSS WILD-TYPE | 153 | 80 | 34 |
P value = 8.17e-06 (Fisher's exact test), Q value = 0.0033
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 37 | 79 | 64 | 78 |
22Q LOSS MUTATED | 0 | 9 | 2 | 21 |
22Q LOSS WILD-TYPE | 37 | 70 | 62 | 57 |
P value = 0.000238 (Fisher's exact test), Q value = 0.089
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 89 | 55 | 92 |
22Q LOSS MUTATED | 11 | 0 | 19 |
22Q LOSS WILD-TYPE | 78 | 55 | 73 |
-
Mutation data file = broad_values_by_arm.mutsig.cluster.txt
-
Molecular subtypes file = STAD-TP.transferedmergedcluster.txt
-
Number of patients = 306
-
Number of significantly arm-level cnvs = 77
-
Number of molecular subtypes = 6
-
Exclude genes that fewer than K tumors have mutations, K = 3
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.