Molecular subtypes CN_CNMF METHLYATION_CNMF MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL nCNV (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Amp Peak 1(1p36.22) 34 (11%) 272 5.2142e-09 2.06e-06 0.0063589 1 0.41206 1 0.55652 1 0.042094 1 0.1814 1 Amp Peak 2(1q21.3) 101 (33%) 205 3.9045e-22 1.73e-19 4.8734e-11 1.98e-08 0.21515 1 0.020274 1 0.00079959 0.253 0.0016418 0.509 Amp Peak 3(1q42.3) 95 (31%) 211 5.9977e-18 2.59e-15 1.6759e-06 0.000623 0.75462 1 0.36101 1 9.6899e-05 0.0331 0.005871 1 Amp Peak 4(3q26.2) 91 (30%) 215 6.1852e-08 2.39e-05 0.0076278 1 0.11591 1 0.1419 1 0.068501 1 0.37782 1 Amp Peak 5(5p15.33) 76 (25%) 230 3.5652e-19 1.56e-16 1.7953e-07 6.84e-05 0.50979 1 0.47597 1 0.0082399 1 0.00078494 0.25 Amp Peak 6(5p13.1) 74 (24%) 232 1.0254e-18 4.47e-16 9.226e-06 0.00337 1 1 0.56103 1 0.031573 1 0.0052468 1 Amp Peak 7(6p21.1) 74 (24%) 232 2.5448e-17 1.09e-14 4.4541e-07 0.000168 0.33189 1 0.67761 1 0.036828 1 0.0011524 0.362 Amp Peak 8(6q12) 56 (18%) 250 2.1831e-10 8.73e-08 1.7747e-05 0.00642 0.50979 1 0.89859 1 0.066925 1 0.017928 1 Amp Peak 9(6q21) 52 (17%) 254 5.5919e-09 2.2e-06 0.00029544 0.0972 0.088339 1 0.36331 1 0.24074 1 0.02164 1 Amp Peak 10(7p22.3) 141 (46%) 165 1.6341e-22 7.24e-20 5.9058e-06 0.00217 0.76255 1 0.42816 1 0.0081093 1 0.0020788 0.634 Amp Peak 11(7p11.2) 128 (42%) 178 4.1535e-20 1.83e-17 0.00040173 0.131 0.54669 1 0.65082 1 0.0043733 1 0.020756 1 Amp Peak 12(7q21.2) 124 (41%) 182 3.2378e-18 1.41e-15 0.0064857 1 0.54669 1 0.43311 1 0.022891 1 0.072933 1 Amp Peak 13(8p23.1) 114 (37%) 192 6.1786e-05 0.0216 0.12044 1 0.36404 1 0.16522 1 0.55777 1 0.62345 1 Amp Peak 14(8q24.21) 186 (61%) 120 5.8189e-09 2.28e-06 0.00049697 0.161 0.28058 1 0.46435 1 0.083808 1 0.020196 1 Amp Peak 15(9p24.1) 45 (15%) 261 0.075184 1 0.10668 1 0.69808 1 0.15927 1 0.70147 1 0.35278 1 Amp Peak 16(9q34.3) 67 (22%) 239 1.3488e-07 5.15e-05 0.060869 1 0.74699 1 1 1 0.39448 1 0.3133 1 Amp Peak 17(10q26.13) 55 (18%) 251 2.4216e-05 0.00867 0.01485 1 1 1 1 1 0.44665 1 0.26962 1 Amp Peak 18(11p13) 48 (16%) 258 0.00070474 0.226 0.26518 1 0.69808 1 0.29321 1 0.22113 1 0.070048 1 Amp Peak 19(11q13.3) 62 (20%) 244 5.1152e-08 1.98e-05 0.089885 1 1 1 0.26386 1 0.010746 1 0.050021 1 Amp Peak 20(12p12.1) 76 (25%) 230 1.2406e-06 0.000464 0.0054721 1 0.41206 1 0.55652 1 0.16 1 0.79878 1 Amp Peak 21(12q15) 69 (23%) 237 3.0258e-05 0.0108 0.0048354 1 0.72051 1 1 1 0.47451 1 0.8036 1 Amp Peak 22(13q12.3) 109 (36%) 197 2.5916e-12 1.07e-09 0.00052724 0.17 0.22314 1 0.11529 1 0.40816 1 0.15094 1 Amp Peak 23(13q22.1) 118 (39%) 188 2.3187e-11 9.46e-09 0.0013015 0.407 0.13084 1 0.65181 1 0.32341 1 0.00077724 0.248 Amp Peak 24(15q26.1) 65 (21%) 241 5.7694e-16 2.45e-13 5.4206e-05 0.0191 1 1 0.88507 1 0.024062 1 0.013245 1 Amp Peak 25(17q12) 83 (27%) 223 3.1082e-17 1.33e-14 0.0017452 0.538 0.73604 1 0.16166 1 0.0088044 1 0.0036189 1 Amp Peak 26(18q11.2) 80 (26%) 226 9.1015e-09 3.56e-06 0.0020272 0.62 1 1 0.61561 1 0.33841 1 0.16432 1 Amp Peak 27(19q12) 82 (27%) 224 7.6547e-18 3.3e-15 2.2021e-08 8.59e-06 0.50979 1 0.060358 1 0.013821 1 1.133e-05 0.00412 Amp Peak 28(20q13.2) 191 (62%) 115 1.9754e-28 8.85e-26 4.2557e-07 0.000161 0.75462 1 0.11648 1 0.031477 1 0.023879 1 Amp Peak 29(Xq26.2) 60 (20%) 246 2.6854e-06 0.000991 0.38476 1 0.28058 1 0.53196 1 0.052445 1 0.92902 1 Del Peak 1(1p36.11) 81 (26%) 225 2.6125e-14 1.09e-11 0.0003913 0.128 0.35798 1 0.53759 1 0.069801 1 0.011841 1 Del Peak 2(1p13.2) 55 (18%) 251 2.4199e-12 1e-09 0.0067353 1 0.16228 1 0.70704 1 0.052445 1 0.030831 1 Del Peak 3(1q44) 21 (7%) 285 0.0072989 1 0.012135 1 0.41206 1 0.83965 1 0.20854 1 0.061731 1 Del Peak 4(2q32.1) 34 (11%) 272 0.00020475 0.0684 0.16384 1 0.66403 1 0.72994 1 0.27886 1 0.061364 1 Del Peak 5(2q37.2) 40 (13%) 266 4.3265e-07 0.000164 0.0069438 1 0.60692 1 0.64265 1 0.11383 1 0.008889 1 Del Peak 6(3p26.1) 77 (25%) 229 3.5344e-12 1.46e-09 0.00059576 0.192 0.18538 1 0.089908 1 0.062313 1 0.0052468 1 Del Peak 7(3p14.2) 97 (32%) 209 4.6567e-15 1.96e-12 0.00010061 0.0343 0.48761 1 0.13786 1 0.20507 1 0.013841 1 Del Peak 8(3q26.31) 32 (10%) 274 1.981e-05 0.00715 0.0089274 1 0.34487 1 0.35593 1 0.059945 1 0.0065904 1 Del Peak 9(4q22.1) 120 (39%) 186 1.5125e-25 6.75e-23 1.2959e-07 4.96e-05 0.22314 1 0.54349 1 0.0033435 0.993 0.00020491 0.0684 Del Peak 10(4q34.3) 111 (36%) 195 9.9044e-21 4.37e-18 1.7752e-06 0.000659 0.030536 1 0.16512 1 0.013813 1 6.3857e-05 0.0223 Del Peak 11(5q11.2) 94 (31%) 212 8.2976e-27 3.71e-24 2.9309e-11 1.19e-08 0.045209 1 0.14976 1 2.2719e-05 0.00816 4.0518e-06 0.00149 Del Peak 12(6p25.3) 66 (22%) 240 7.1181e-10 2.83e-07 0.0029039 0.865 0.69808 1 0.42391 1 0.28028 1 0.00029289 0.0967 Del Peak 13(6q26) 58 (19%) 248 2.7147e-07 0.000103 0.018452 1 0.45655 1 0.60269 1 0.22263 1 0.16146 1 Del Peak 14(7q31.1) 41 (13%) 265 3.0198e-08 1.17e-05 0.0039734 1 0.41206 1 0.55652 1 0.030548 1 0.083854 1 Del Peak 15(7q36.3) 55 (18%) 251 3.804e-17 1.62e-14 7.8739e-06 0.00288 0.69808 1 0.49912 1 0.17944 1 0.0016965 0.524 Del Peak 16(8p23.2) 71 (23%) 235 3.779e-18 1.64e-15 2.1749e-06 0.000805 0.50979 1 0.89859 1 0.047351 1 0.00017717 0.0595 Del Peak 17(9p23) 110 (36%) 196 1.5878e-23 7.07e-21 0.00028502 0.0943 0.12426 1 0.44922 1 0.033106 1 0.026195 1 Del Peak 18(9p21.3) 109 (36%) 197 5.6465e-23 2.51e-20 1.1851e-09 4.69e-07 0.21515 1 0.83869 1 0.0066167 1 0.0024305 0.739 Del Peak 19(9q21.11) 68 (22%) 238 1.1217e-14 4.71e-12 0.0018052 0.554 0.69808 1 0.64102 1 0.081703 1 0.0024815 0.749 Del Peak 20(10p14) 39 (13%) 267 6.6416e-08 2.56e-05 0.003753 1 0.72051 1 0.88507 1 0.016654 1 0.045935 1 Del Peak 21(10q22.3) 46 (15%) 260 4.0223e-12 1.65e-09 8.9162e-05 0.0309 0.13239 1 0.15048 1 0.019372 1 0.0015599 0.485 Del Peak 22(10q23.31) 67 (22%) 239 1.1678e-18 5.08e-16 1.3641e-06 0.000509 0.0068449 1 0.089908 1 8.965e-05 0.0309 4.6912e-05 0.0166 Del Peak 23(11p15.4) 56 (18%) 250 1.3389e-10 5.41e-08 0.00016246 0.0549 1 1 1 1 0.17274 1 0.0026858 0.806 Del Peak 24(11q23.2) 55 (18%) 251 1.1829e-06 0.000444 0.00087204 0.276 1 1 0.21463 1 0.060725 1 0.22129 1 Del Peak 25(12p13.31) 46 (15%) 260 2.2849e-11 9.35e-09 0.0024404 0.739 1 1 1 1 0.08018 1 0.33515 1 Del Peak 26(13q14.2) 40 (13%) 266 3.1211e-05 0.0111 0.01935 1 0.41206 1 0.55652 1 0.40446 1 0.879 1 Del Peak 27(14q21.1) 67 (22%) 239 1.0579e-09 4.2e-07 0.041152 1 0.13239 1 0.67439 1 0.034287 1 0.017706 1 Del Peak 28(14q32.33) 81 (26%) 225 2.7032e-10 1.08e-07 0.036975 1 0.088339 1 0.4576 1 0.25067 1 0.17404 1 Del Peak 29(15q11.2) 73 (24%) 233 2.3962e-16 1.02e-13 2.8607e-05 0.0102 0.0093419 1 0.010985 1 0.010034 1 0.0001066 0.0362 Del Peak 30(15q15.1) 75 (25%) 231 3.9243e-15 1.66e-12 9.1886e-05 0.0315 0.045209 1 0.089908 1 0.035369 1 5.9551e-05 0.0209 Del Peak 31(16p13.3) 52 (17%) 254 3.294e-12 1.36e-09 0.0006761 0.217 1 1 0.64102 1 0.014281 1 0.18078 1 Del Peak 32(16q23.1) 104 (34%) 202 1.1278e-10 4.57e-08 0.026617 1 0.54337 1 0.91536 1 0.66532 1 0.18215 1 Del Peak 33(17p12) 103 (34%) 203 8.3164e-32 3.74e-29 9.3582e-08 3.59e-05 0.20275 1 0.50906 1 0.0014182 0.442 2.0086e-05 0.00723 Del Peak 34(17q24.3) 50 (16%) 256 9.379e-12 3.85e-09 0.022507 1 0.088339 1 0.055065 1 0.014457 1 0.0011503 0.362 Del Peak 35(18q21.2) 124 (41%) 182 8.7687e-19 3.83e-16 8.9208e-05 0.0309 0.76349 1 0.19112 1 0.11159 1 0.014249 1 Del Peak 36(18q23) 116 (38%) 190 1.2104e-17 5.2e-15 1.5791e-05 0.00573 1 1 0.9173 1 0.045823 1 0.0051188 1 Del Peak 37(19p13.3) 91 (30%) 215 2.7514e-29 1.24e-26 1.9835e-12 8.25e-10 0.34747 1 0.36101 1 0.00016945 0.0571 5.7857e-09 2.27e-06 Del Peak 38(19q13.11) 40 (13%) 266 1.3932e-10 5.61e-08 0.00014165 0.048 0.094572 1 0.22978 1 0.0035446 1 5.2174e-05 0.0184 Del Peak 39(20p12.1) 50 (16%) 256 1.8648e-10 7.5e-08 7.7318e-05 0.0269 1 1 0.83965 1 0.024356 1 0.015975 1 Del Peak 40(20p12.1) 50 (16%) 256 1.8648e-10 7.5e-08 7.7318e-05 0.0269 1 1 0.83965 1 0.024356 1 0.015975 1 Del Peak 41(21q11.2) 97 (32%) 209 2.7463e-15 1.16e-12 0.00027957 0.0928 0.50979 1 0.89859 1 0.011543 1 0.27471 1 Del Peak 42(21q22.13) 102 (33%) 204 6.0662e-16 2.57e-13 0.00040461 0.131 0.21515 1 0.57977 1 0.06152 1 0.14265 1 Del Peak 43(22q13.31) 91 (30%) 215 1.6068e-19 7.05e-17 1.0543e-06 0.000396 1 1 1 1 0.0027729 0.829 0.00019023 0.0637 Del Peak 44(Xp22.2) 52 (17%) 254 2.6369e-14 1.1e-11 0.00031084 0.102 0.69808 1 0.73203 1 0.13075 1 0.0083929 1 Del Peak 45(Xp21.1) 45 (15%) 261 1.5419e-13 6.43e-11 0.0045923 1 0.28058 1 0.28273 1 0.020849 1 0.076217 1 Del Peak 46(Xq21.33) 38 (12%) 268 8.309e-08 3.2e-05 0.0026062 0.784 0.45655 1 0.67439 1 0.049573 1 0.010772 1