Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.099 0.314 -9999.0 0.0 -0.924 4.0 4.0 IHH -0.122 0.319 -9999.0 0.0 -0.905 6.0 6.0 SHH Np/Cholesterol/GAS1 -0.165 0.241 -9999.0 0.0 -0.553 11.0 11.0 LRPAP1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.164 0.239 0.548 11.0 -9999.0 0.0 11.0 SMO/beta Arrestin2 -0.117 0.282 -9999.0 0.0 -0.771 5.0 5.0 SMO -0.129 0.298 -9999.0 0.0 -0.732 7.0 7.0 AKT1 -0.034 0.118 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.057 0.189 -9999.0 0.0 -0.561 5.0 5.0 ADRBK1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.126 0.291 -9999.0 0.0 -0.716 7.0 7.0 STIL -0.185 0.352 -9999.0 0.0 -0.86 6.0 6.0 DHH N/PTCH2 -0.031 0.121 -9999.0 0.0 -0.449 3.0 3.0 DHH N/PTCH1 -0.125 0.242 -9999.0 0.0 -0.587 8.0 8.0 PIK3CA 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.011 0.13 -9999.0 0.0 -0.85 1.0 1.0 PTHLH -0.118 0.37 -9999.0 0.0 -1.091 4.0 4.0 determination of left/right symmetry -0.126 0.291 -9999.0 0.0 -0.716 7.0 7.0 PIK3R1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.116 0.362 -9999.0 0.0 -1.067 4.0 4.0 IHH N/Hhip -0.242 0.336 -9999.0 0.0 -0.602 18.0 18.0 DHH N/Hhip -0.171 0.252 -9999.0 0.0 -0.66 7.0 7.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.126 0.291 -9999.0 0.0 -0.716 7.0 7.0 pancreas development -0.203 0.322 -9999.0 0.0 -0.643 14.0 14.0 HHAT -0.011 0.13 -9999.0 0.0 -0.85 1.0 1.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.042 0.194 -9999.0 0.0 -0.73 3.0 3.0 somite specification -0.126 0.291 -9999.0 0.0 -0.716 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.194 0.344 -9999.0 0.0 -0.65 13.0 13.0 SHH Np/Cholesterol/PTCH2 -0.147 0.223 -9999.0 0.0 -0.529 10.0 10.0 SHH Np/Cholesterol/Megalin -0.23 0.287 -9999.0 0.0 -0.632 12.0 12.0 SHH -0.158 0.278 -9999.0 0.0 -0.66 9.0 9.0 catabolic process -0.094 0.273 -9999.0 0.0 -0.63 8.0 8.0 SMO/Vitamin D3 -0.194 0.347 -9999.0 0.0 -0.864 6.0 6.0 SHH Np/Cholesterol/Hhip -0.255 0.289 -9999.0 0.0 -0.617 14.0 14.0 LRP2 -0.163 0.292 -9999.0 0.0 -0.609 12.0 12.0 receptor-mediated endocytosis -0.262 0.335 -9999.0 0.0 -0.843 8.0 8.0 SHH Np/Cholesterol/BOC -0.171 0.227 -9999.0 0.0 -0.529 11.0 11.0 SHH Np/Cholesterol/CDO -0.141 0.216 -9999.0 0.0 -0.53 9.0 9.0 mesenchymal cell differentiation 0.252 0.285 0.611 14.0 -9999.0 0.0 14.0 mol:Vitamin D3 -0.192 0.346 -9999.0 0.0 -0.651 13.0 13.0 IHH N/PTCH2 -0.093 0.229 -9999.0 0.0 -0.562 8.0 8.0 CDON -0.002 0.075 -9999.0 0.0 -0.489 1.0 1.0 IHH N/PTCH1 -0.096 0.277 -9999.0 0.0 -0.638 8.0 8.0 Megalin/LRPAP1 -0.125 0.216 -9999.0 0.0 -0.449 12.0 12.0 PTCH2 -0.014 0.105 -9999.0 0.0 -0.489 2.0 2.0 SHH Np/Cholesterol -0.137 0.219 -9999.0 0.0 -0.537 9.0 9.0 PTCH1 -0.095 0.275 -9999.0 0.0 -0.633 8.0 8.0 HHIP -0.203 0.323 -9999.0 0.0 -0.644 14.0 14.0