Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	9.0	436.0	46.0	-0.835	0.034	1000.0	-1000.0	-0.141	-1000.0
Signaling events mediated by the Hedgehog family	6.0	347.0	52.0	-0.262	0.252	1000.0	-1000.0	-0.107	-1000.0
IL23-mediated signaling events	6.0	387.0	60.0	-0.538	0.01	1000.0	-1000.0	-0.199	-1000.0
Ephrin A  reverse signaling	5.0	38.0	7.0	-0.12	0.0	1000.0	-1000.0	-0.039	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	4.0	144.0	34.0	-0.156	0.009	1000.0	-1000.0	-0.08	-1000.0
Glypican 1 network	4.0	213.0	48.0	-0.243	0.013	1000.0	-1000.0	-0.069	-1000.0
Signaling events regulated by Ret tyrosine kinase	4.0	367.0	82.0	-0.238	0.009	1000.0	-1000.0	-0.112	-1000.0
Visual signal transduction: Rods	4.0	208.0	52.0	-0.28	0.009	1000.0	-1000.0	-0.102	-1000.0
Syndecan-1-mediated signaling events	3.0	118.0	34.0	-0.195	0.009	1000.0	-1000.0	-0.092	-1000.0
Visual signal transduction: Cones	3.0	141.0	38.0	-0.264	0.009	1000.0	-1000.0	-0.088	-1000.0
p75(NTR)-mediated signaling	3.0	441.0	125.0	-0.327	0.009	1000.0	-1000.0	-0.135	-1000.0
IL4-mediated signaling events	3.0	354.0	91.0	-0.674	0.488	1000.0	-1000.0	-0.224	-1000.0
BMP receptor signaling	3.0	317.0	81.0	-0.377	0.021	1000.0	-1000.0	-0.122	-1000.0
Glucocorticoid receptor regulatory network	3.0	361.0	114.0	-0.594	0.314	1000.0	-1000.0	-0.09	-1000.0
Effects of Botulinum toxin	3.0	81.0	26.0	-0.204	0.009	1000.0	-1000.0	-0.083	-1000.0
Wnt signaling	3.0	25.0	7.0	-0.117	-0.031	1000.0	-1000.0	-0.049	-1000.0
TCGA08_retinoblastoma	3.0	30.0	8.0	-0.108	0.039	1000.0	-1000.0	-0.033	-1000.0
Syndecan-4-mediated signaling events	3.0	211.0	67.0	-0.175	0.03	1000.0	-1000.0	-0.125	-1000.0
IL12-mediated signaling events	2.0	183.0	87.0	-0.214	0.031	1000.0	-1000.0	-0.164	-1000.0
ErbB4 signaling events	2.0	180.0	69.0	-0.217	0.071	1000.0	-1000.0	-0.121	-1000.0
Noncanonical Wnt signaling pathway	2.0	56.0	26.0	-0.117	0.009	1000.0	-1000.0	-0.117	-1000.0
Fc-epsilon receptor I signaling in mast cells	2.0	215.0	97.0	-0.187	0.028	1000.0	-1000.0	-0.11	-1000.0
amb2 Integrin signaling	2.0	227.0	82.0	-0.301	0.009	1000.0	-1000.0	-0.108	-1000.0
Reelin signaling pathway	2.0	134.0	56.0	-0.171	0.009	1000.0	-1000.0	-0.105	-1000.0
IL1-mediated signaling events	2.0	133.0	62.0	-0.268	0.053	1000.0	-1000.0	-0.124	-1000.0
TCGA08_p53	2.0	18.0	7.0	-0.08	0.037	1000.0	-1000.0	-0.023	-1000.0
TCR signaling in naïve CD8+ T cells	2.0	241.0	93.0	-0.169	0.086	1000.0	-1000.0	-0.111	-1000.0
EPHB forward signaling	2.0	218.0	85.0	-0.179	0.125	1000.0	-1000.0	-0.121	-1000.0
BCR signaling pathway	2.0	212.0	99.0	-0.151	0.022	1000.0	-1000.0	-0.119	-1000.0
EGFR-dependent Endothelin signaling events	2.0	45.0	21.0	-0.113	0.009	1000.0	-1000.0	-0.09	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	2.0	263.0	120.0	-0.279	0.145	1000.0	-1000.0	-0.099	-1000.0
LPA4-mediated signaling events	1.0	12.0	12.0	-0.082	0.015	1000.0	-1000.0	-0.044	-1000.0
ErbB2/ErbB3 signaling events	1.0	85.0	65.0	-0.151	0.02	1000.0	-1000.0	-0.093	-1000.0
Caspase cascade in apoptosis	1.0	130.0	74.0	-0.125	0.026	1000.0	-1000.0	-0.064	-1000.0
Coregulation of Androgen receptor activity	1.0	85.0	76.0	-0.117	0.026	1000.0	-1000.0	-0.075	-1000.0
PLK2 and PLK4 events	1.0	4.0	3.0	-0.011	-0.007	1000.0	-1000.0	-0.032	-1000.0
Osteopontin-mediated events	1.0	56.0	38.0	-0.094	0.013	1000.0	-1000.0	-0.136	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	1.0	93.0	54.0	-0.15	0.019	1000.0	-1000.0	-0.127	-1000.0
Thromboxane A2 receptor signaling	1.0	141.0	105.0	-0.113	0.023	1000.0	-1000.0	-0.094	-1000.0
HIF-1-alpha transcription factor network	1.0	118.0	76.0	-0.434	0.015	1000.0	-1000.0	-0.289	-1000.0
Syndecan-2-mediated signaling events	1.0	99.0	69.0	-0.189	0.031	1000.0	-1000.0	-0.086	-1000.0
Cellular roles of Anthrax toxin	1.0	40.0	39.0	-0.083	0.013	1000.0	-1000.0	-0.04	-1000.0
Arf6 signaling events	1.0	79.0	62.0	-0.255	0.015	1000.0	-1000.0	-0.089	-1000.0
Signaling events mediated by PTP1B	1.0	87.0	76.0	-0.167	0.015	1000.0	-1000.0	-0.103	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	89.0	61.0	-0.37	0.034	1000.0	-1000.0	-0.093	-1000.0
Aurora C signaling	1.0	7.0	7.0	-0.048	0.0	1000.0	-1000.0	-0.051	-1000.0
Nectin adhesion pathway	1.0	95.0	63.0	-0.096	0.012	1000.0	-1000.0	-0.097	-1000.0
Signaling events mediated by HDAC Class III	1.0	42.0	40.0	-0.192	0.017	1000.0	-1000.0	-0.056	-1000.0
TRAIL signaling pathway	1.0	53.0	48.0	-0.077	0.029	1000.0	-1000.0	-0.084	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	61.0	52.0	-0.167	0.018	1000.0	-1000.0	-0.099	-1000.0
Ephrin B reverse signaling	1.0	70.0	48.0	-0.126	0.126	1000.0	-1000.0	-0.088	-1000.0
Endothelins	1.0	186.0	96.0	-0.232	0.052	1000.0	-1000.0	-0.122	-1000.0
FAS signaling pathway (CD95)	1.0	47.0	47.0	-0.192	0.011	1000.0	-1000.0	-0.07	-1000.0
Retinoic acid receptors-mediated signaling	1.0	77.0	58.0	-0.135	0.017	1000.0	-1000.0	-0.106	-1000.0
Syndecan-3-mediated signaling events	1.0	49.0	35.0	-0.189	0.009	1000.0	-1000.0	-0.093	-1000.0
IL2 signaling events mediated by PI3K	1.0	68.0	58.0	-0.169	0.035	1000.0	-1000.0	-0.116	-1000.0
Signaling mediated by p38-alpha and p38-beta	1.0	50.0	44.0	-0.169	0.009	1000.0	-1000.0	-0.066	-1000.0
Canonical Wnt signaling pathway	1.0	82.0	51.0	-0.37	0.053	1000.0	-1000.0	-0.104	-1000.0
Glypican 2 network	1.0	7.0	4.0	-0.042	-0.039	1000.0	-1000.0	-0.054	-1000.0
Calcium signaling in the CD4+ TCR pathway	1.0	41.0	31.0	-0.164	0.011	1000.0	-1000.0	-0.115	-1000.0
Nongenotropic Androgen signaling	1.0	72.0	52.0	-0.077	0.009	1000.0	-1000.0	-0.084	-1000.0
IL27-mediated signaling events	1.0	85.0	51.0	-0.233	0.013	1000.0	-1000.0	-0.105	-1000.0
IL6-mediated signaling events	1.0	93.0	75.0	-0.217	0.035	1000.0	-1000.0	-0.121	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	1.0	123.0	68.0	-0.245	0.022	1000.0	-1000.0	-0.185	-1000.0
IL2 signaling events mediated by STAT5	1.0	23.0	22.0	-0.057	0.025	1000.0	-1000.0	-0.09	-1000.0
Regulation of Telomerase	1.0	150.0	102.0	-0.264	0.029	1000.0	-1000.0	-0.132	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.011	-1000.0	1000.0	-1000.0	-0.014	-1000.0
FOXM1 transcription factor network	1.0	56.0	51.0	-0.117	0.142	1000.0	-1000.0	-0.248	-1000.0
Regulation of Androgen receptor activity	1.0	71.0	70.0	-0.281	0.02	1000.0	-1000.0	-0.096	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	18.0	17.0	-0.029	0.011	1000.0	-1000.0	-0.063	-1000.0
Aurora B signaling	1.0	68.0	67.0	-0.229	0.01	1000.0	-1000.0	-0.096	-1000.0
Regulation of nuclear SMAD2/3 signaling	0.0	90.0	136.0	-0.126	0.056	1000.0	-1000.0	-0.106	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.0	0.036	1000.0	-1000.0	-0.098	-1000.0
Canonical NF-kappaB pathway	0.0	9.0	39.0	-0.054	0.061	1000.0	-1000.0	-0.113	-1000.0
Signaling events mediated by HDAC Class II	0.0	12.0	75.0	-0.031	0.021	1000.0	-1000.0	-0.082	-1000.0
BARD1 signaling events	0.0	37.0	57.0	-0.039	0.036	1000.0	-1000.0	-0.1	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	16.0	28.0	-0.065	0.018	1000.0	-1000.0	-0.076	-1000.0
Circadian rhythm pathway	0.0	2.0	22.0	-0.015	0.035	1000.0	-1000.0	-0.087	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	14.0	17.0	-0.035	0.018	1000.0	-1000.0	-0.094	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	4.0	5.0	-0.028	-0.011	1000.0	-1000.0	-0.044	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	0.0	30.0	85.0	-0.04	0.038	1000.0	-1000.0	-0.097	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	58.0	65.0	-0.172	0.037	1000.0	-1000.0	-0.088	-1000.0
Aurora A signaling	0.0	49.0	60.0	-0.185	0.02	1000.0	-1000.0	-0.083	-1000.0
Arf6 downstream pathway	0.0	40.0	43.0	-0.028	0.02	1000.0	-1000.0	-0.05	-1000.0
EPO signaling pathway	0.0	12.0	55.0	-0.038	0.054	1000.0	-1000.0	-0.116	-1000.0
PLK1 signaling events	0.0	61.0	85.0	-0.043	0.013	1000.0	-1000.0	-0.072	-1000.0
Insulin-mediated glucose transport	0.0	4.0	32.0	-0.023	0.026	1000.0	-1000.0	-0.083	-1000.0
PDGFR-alpha signaling pathway	0.0	13.0	44.0	-0.027	0.025	1000.0	-1000.0	-0.067	-1000.0
mTOR signaling pathway	0.0	9.0	53.0	-0.011	0.028	1000.0	-1000.0	-0.08	-1000.0
IFN-gamma pathway	0.0	58.0	68.0	-0.114	0.028	1000.0	-1000.0	-0.133	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	11.0	68.0	-0.033	0.038	1000.0	-1000.0	-0.098	-1000.0
Ceramide signaling pathway	0.0	34.0	76.0	-0.113	0.029	1000.0	-1000.0	-0.084	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	33.0	37.0	-0.125	0.014	1000.0	-1000.0	-0.1	-1000.0
S1P5 pathway	0.0	12.0	17.0	-0.065	0.036	1000.0	-1000.0	-0.066	-1000.0
ceramide signaling pathway	0.0	7.0	49.0	-0.054	0.03	1000.0	-1000.0	-0.08	-1000.0
HIF-2-alpha transcription factor network	0.0	18.0	43.0	-0.094	0.096	1000.0	-1000.0	-0.138	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	24.0	83.0	-0.137	0.039	1000.0	-1000.0	-0.114	-1000.0
S1P1 pathway	0.0	33.0	36.0	-0.1	0.013	1000.0	-1000.0	-0.075	-1000.0
Signaling events mediated by HDAC Class I	0.0	26.0	104.0	-0.054	0.037	1000.0	-1000.0	-0.103	-1000.0
FoxO family signaling	0.0	44.0	64.0	-0.124	0.076	1000.0	-1000.0	-0.116	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	9.0	15.0	-0.022	0.023	1000.0	-1000.0	-0.048	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	13.0	36.0	-0.028	0.018	1000.0	-1000.0	-0.094	-1000.0
Atypical NF-kappaB pathway	0.0	3.0	31.0	-0.042	0.021	1000.0	-1000.0	-0.1	-1000.0
Integrins in angiogenesis	0.0	72.0	84.0	-0.12	0.031	1000.0	-1000.0	-0.12	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	16.0	45.0	-0.088	0.04	1000.0	-1000.0	-0.126	-1000.0
Regulation of p38-alpha and p38-beta	0.0	27.0	54.0	-0.083	0.009	1000.0	-1000.0	-0.093	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	9.0	125.0	-0.022	0.071	1000.0	-1000.0	-0.124	-1000.0
TCGA08_rtk_signaling	0.0	13.0	26.0	-0.046	0.028	1000.0	-1000.0	-0.032	-1000.0
LPA receptor mediated events	0.0	92.0	102.0	-0.104	0.024	1000.0	-1000.0	-0.125	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	0.0	73.0	74.0	-0.232	0.048	1000.0	-1000.0	-0.12	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	38.0	76.0	-0.028	0.03	1000.0	-1000.0	-0.11	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.006	0.022	1000.0	-1000.0	-0.078	-1000.0
Class I PI3K signaling events	0.0	40.0	73.0	-0.083	0.028	1000.0	-1000.0	-0.102	-1000.0
Arf6 trafficking events	0.0	21.0	71.0	-0.085	0.033	1000.0	-1000.0	-0.097	-1000.0
IGF1 pathway	0.0	14.0	57.0	-0.083	0.015	1000.0	-1000.0	-0.139	-1000.0
Insulin Pathway	0.0	28.0	74.0	-0.137	0.028	1000.0	-1000.0	-0.126	-1000.0
Plasma membrane estrogen receptor signaling	0.0	75.0	86.0	-0.083	0.023	1000.0	-1000.0	-0.108	-1000.0
VEGFR1 specific signals	0.0	4.0	56.0	-0.013	0.048	1000.0	-1000.0	-0.103	-1000.0
S1P3 pathway	0.0	18.0	42.0	-0.064	0.02	1000.0	-1000.0	-0.077	-1000.0
Angiopoietin receptor Tie2-mediated signaling	0.0	64.0	88.0	-0.254	0.071	1000.0	-1000.0	-0.141	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	24.0	33.0	-0.109	0.029	1000.0	-1000.0	-0.09	-1000.0
Rapid glucocorticoid signaling	0.0	9.0	20.0	-0.022	0.009	1000.0	-1000.0	-0.056	-1000.0
PDGFR-beta signaling pathway	0.0	18.0	97.0	-0.062	0.042	1000.0	-1000.0	-0.123	-1000.0
Signaling events mediated by PRL	0.0	32.0	34.0	-0.132	0.021	1000.0	-1000.0	-0.073	-1000.0
E-cadherin signaling in keratinocytes	0.0	16.0	43.0	-0.023	0.03	1000.0	-1000.0	-0.091	-1000.0
S1P4 pathway	0.0	12.0	25.0	-0.065	0.025	1000.0	-1000.0	-0.072	-1000.0
E-cadherin signaling events	0.0	4.0	5.0	-0.02	0.009	1000.0	-1000.0	-0.06	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	0.0	71.0	78.0	-0.052	0.028	1000.0	-1000.0	-0.116	-1000.0
p38 MAPK signaling pathway	0.0	12.0	44.0	-0.057	0.024	1000.0	-1000.0	-0.08	-1000.0
Arf1 pathway	0.0	0.0	54.0	-0.0	0.027	1000.0	-1000.0	-0.055	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	-0.015	0.009	1000.0	-1000.0	-0.077	-1000.0
Total	138	10750	7203	-18.7766057098	-995.348957147	131000	-131000	-12.8234977577	-131000