rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(5)	125186	5	5	5	1	1	0	1	1	2	0	0.548	0.00891	1.000
2	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(2), DCN(2), FMOD(9), KERA(1), LUM(2)	629673	16	14	16	2	8	3	0	5	0	0	0.0825	0.0325	1.000
3	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(3), ERBB4(16), NRG2(4), NRG3(9), PSEN1(1)	1555655	33	24	33	5	7	13	4	5	4	0	0.0234	0.0558	1.000
4	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2), CD3G(2)	196753	4	4	3	1	0	1	1	0	2	0	0.822	0.105	1.000
5	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(2), NR3C1(4), PPARG(1), RXRA(2), TNF(1)	999771	10	10	10	1	2	1	1	5	1	0	0.207	0.210	1.000
6	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCL5(1), CCR3(4), HLA-DRA(3), HLA-DRB1(1), IL3(1)	526404	11	10	11	3	4	4	0	2	1	0	0.352	0.227	1.000
7	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ADRB2(3), AKT1(2), ANXA1(3), CALM1(1), CALM2(2), CALM3(1), GNAS(11), GNGT1(3), NFKB1(5), NOS3(3), NPPA(1), NR3C1(4), PIK3R1(5), RELA(1)	2722623	45	28	45	7	13	12	0	11	9	0	0.0412	0.265	1.000
8	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3E(2), CD3G(2), IFNG(2), IL2RA(1), TGFB1(3), TGFB2(6), TGFB3(3), TGFBR1(2), TGFBR2(6), TGFBR3(2), TOB1(1), TOB2(4)	1836086	34	24	33	6	6	11	3	10	4	0	0.107	0.300	1.000
9	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(5), GABRA2(5), GABRA3(5), GABRA4(4), GABRA5(4), GABRA6(5), PRKCE(5)	1366369	33	21	33	9	11	7	5	9	1	0	0.197	0.308	1.000
10	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(3), IL8(1), SLPI(1)	296007	5	4	5	1	2	2	0	1	0	0	0.387	0.379	1.000
11	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), UGDH(4)	1471353	23	19	23	4	6	6	0	8	3	0	0.0892	0.393	1.000
12	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(2), FOSB(2), GRIA2(13)	648611	17	13	17	4	5	9	0	2	1	0	0.196	0.427	1.000
13	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(2), CAT(4), GH1(1), GHR(3), IGF1(2), IGF1R(10), PIK3R1(5), SHC1(3)	1918453	30	20	30	5	5	11	2	6	6	0	0.0713	0.534	1.000
14	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF3(1), FLT3(6), IGF1(2), IL11(2), IL3(1), KITLG(3), TGFB1(3), TGFB2(6), TGFB3(3)	1437254	27	19	27	6	6	10	0	7	4	0	0.193	0.543	1.000
15	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(5), AOC2(4), AOC3(3), CES1(6), ESD(1)	1047338	19	14	19	3	4	7	1	7	0	0	0.101	0.560	1.000
16	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH6(2), ADH7(1), ADHFE1(6)	976965	16	14	15	4	2	6	0	4	4	0	0.349	0.575	1.000
17	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(4), CD4(2), HLA-DRA(3), HLA-DRB1(1), IL1B(1), IL5RA(1)	926361	13	12	13	4	3	4	0	4	2	0	0.487	0.590	1.000
18	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IFNG(2), IL12B(1)	517423	4	4	4	1	0	1	1	2	0	0	0.614	0.594	1.000
19	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(1), TGDS(2), UGDH(4), UXS1(3)	678604	11	10	11	3	4	3	1	2	1	0	0.437	0.599	1.000
20	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP3(1), CASP8(5), CFL1(1)	667026	8	7	8	2	1	2	1	3	1	0	0.530	0.631	1.000
21	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH5(1), ADH6(2), ADH7(1), ADHFE1(6), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3)	2297442	36	24	35	7	7	11	0	11	7	0	0.0647	0.636	1.000
22	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1), SUCLA2(3)	363781	4	4	4	0	1	0	0	1	2	0	0.380	0.639	1.000
23	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), GSTZ1(3), HGD(2)	386905	6	5	6	2	3	0	0	3	0	0	0.606	0.662	1.000
24	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(3), CPS1(14), GLS(4), GLUD1(4), GOT1(1)	1349193	28	22	28	7	8	6	2	10	2	0	0.262	0.669	1.000
25	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(2), PIK3R1(5), PLCB1(10), PLCG1(10), VAV1(6)	1841841	33	23	32	7	12	10	0	4	7	0	0.143	0.672	1.000
26	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CCL2(1), LDLR(4), LPL(2)	920322	9	9	9	3	3	2	0	2	2	0	0.453	0.727	1.000
27	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1), TPI1(2)	280776	3	3	3	0	2	1	0	0	0	0	0.319	0.733	1.000
28	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(19), CDH1(12), CREBBP(10), EP300(13), MAP2K1(2), MAP3K7(6), MAPK3(1), SKIL(2), TGFB1(3), TGFB2(6), TGFB3(3), TGFBR1(2), TGFBR2(6)	4439792	85	44	84	21	16	28	4	17	19	1	0.116	0.752	1.000
29	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(2), PDXK(3), PDXP(1), PNPO(1), PSAT1(2)	834435	9	8	9	3	1	3	0	3	1	1	0.604	0.766	1.000
30	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), PARK2(9), SNCAIP(7), UBE2F(3), UBE2G2(1), UBE2L3(1), UBE2L6(1)	1111381	24	18	24	6	8	9	0	4	3	0	0.147	0.767	1.000
31	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(2), CAMP(1), DAG1(5), GNAQ(1), ITPKA(1), ITPKB(5)	1043326	15	13	15	4	5	4	0	3	2	1	0.393	0.771	1.000
32	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), IL1B(1), MST1(2), MST1R(7), TNF(1)	1128041	12	11	12	1	5	3	0	3	1	0	0.0685	0.795	1.000
33	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNAQ(1), GNGT1(3), HTR2C(3), PLCB1(10), TUB(5)	1237819	24	16	24	7	8	7	0	4	5	0	0.376	0.812	1.000
34	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(1), CASP7(2), DFFA(2), DFFB(2), ENDOG(1), HMGB2(1), TOP2A(6), TOP2B(8)	1651071	23	14	21	4	2	9	1	4	7	0	0.248	0.816	1.000
35	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	RB1(7), SP1(3), SP3(3)	1152948	13	11	12	3	1	8	0	2	2	0	0.284	0.820	1.000
36	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD34(2), CD3E(2), CD3G(2), CD4(2), CD58(1), CD8A(2), CSF3(1), IL3(1), IL8(1), KITLG(3)	1072958	19	17	18	6	3	6	1	5	4	0	0.530	0.827	1.000
37	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(3), GAD1(3), GAD2(3), GGT1(3)	992300	13	11	13	3	6	2	0	5	0	0	0.283	0.849	1.000
38	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOB(2), ALDOC(2), TPI1(2)	672915	7	7	7	2	2	2	0	3	0	0	0.533	0.869	1.000
39	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(2), HLA-DRA(3), HLA-DRB1(1)	413147	6	6	6	3	1	2	0	3	0	0	0.823	0.872	1.000
40	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), F13B(8), HSD17B1(3), HSD17B3(1), HSD17B4(1), HSD17B7(1), HSD3B1(1), HSD3B2(1)	1406263	18	17	18	5	4	6	1	4	3	0	0.259	0.880	1.000
41	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ3(2), COQ6(2), COQ7(1), NDUFA13(1)	696871	7	6	7	2	3	3	0	1	0	0	0.554	0.881	1.000
42	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(3), CDC34(1), CDK2(2), CUL1(8), FBXW7(8), RB1(7), TFDP1(2)	1439623	31	18	28	9	9	9	1	7	5	0	0.273	0.887	1.000
43	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(2), CD80(1), HLA-DRA(3), HLA-DRB1(1), IL10(1)	691290	8	8	8	3	2	2	0	4	0	0	0.716	0.887	1.000
44	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), CD36(2), FYN(5), JUN(2), MAPK14(1), THBS1(7)	1275013	18	13	18	4	5	6	0	5	2	0	0.207	0.891	1.000
45	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(14), C5(8), C6(6), C7(2), C8A(6), C9(3)	2199552	39	25	39	10	14	10	1	12	2	0	0.170	0.896	1.000
46	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(4), GLS2(4), GLUD1(4), GLUD2(6)	783586	18	12	18	5	5	5	0	7	1	0	0.391	0.900	1.000
47	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(8), APOBEC1(3), APOBEC3A(1), APOBEC3B(2), APOBEC3G(2), APOBEC4(1)	1268440	17	13	17	4	8	3	2	3	1	0	0.280	0.902	1.000
48	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1), LIPT1(3)	265065	4	4	4	2	0	2	0	1	1	0	0.754	0.906	1.000
49	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(2), IFNGR2(1), JAK1(2), JAK2(8), STAT1(4)	1423019	19	12	19	5	4	6	1	4	3	1	0.366	0.907	1.000
50	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(2), APC(19), AXIN1(7), CCND1(1), CD14(1), CTNNB1(10), DVL1(2), FZD1(5), GJA1(8), GNAI1(1), GSK3B(2), IRAK1(4), LEF1(4), MYD88(1), NFKB1(5), PDPK1(1), PIK3R1(5), PPP2CA(3), RELA(1), TIRAP(2), TLR4(11), TOLLIP(1), WNT1(3)	4927943	99	47	96	24	22	24	5	27	19	2	0.0606	0.907	1.000
51	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(1), HLCS(1), SPCS3(1)	535499	3	3	3	0	2	0	0	1	0	0	0.294	0.915	1.000
52	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD3E(2), CD3G(2), CD4(2)	557038	7	7	6	3	0	2	1	2	2	0	0.907	0.919	1.000
53	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(1), TGDS(2), UGDH(4), UGP2(1), UXS1(3)	860376	12	11	12	4	5	3	1	2	1	0	0.511	0.923	1.000
54	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	AKT1(2), BCAR1(4), GRB2(1), ILK(1), ITGB1(4), MAPK1(2), MAPK3(1), PDPK1(1), PIK3R1(5), PTEN(8), PTK2(7), SHC1(3), SOS1(3)	2946236	42	27	41	9	4	15	4	7	12	0	0.127	0.926	1.000
55	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(5), BMPR1A(1), BMPR1B(2), BMPR2(10)	1080536	18	14	17	6	7	4	0	3	2	2	0.658	0.927	1.000
56	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(3), GNAS(11), GNGT1(3), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6)	1656186	30	22	30	8	11	7	1	7	4	0	0.321	0.928	1.000
57	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(3), F13A1(7), F2(3), F2R(1), FGA(4), FGB(2), PLAT(2), PLAU(2), PLG(8), SERPINB2(2), SERPINE1(2)	2319038	36	24	36	9	12	9	2	8	5	0	0.122	0.933	1.000
58	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(8), FH(2), MDH1(3), SDHB(3), SUCLA2(3)	1539444	19	13	18	3	9	5	0	3	2	0	0.0907	0.934	1.000
59	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(2), BAK1(2), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP3(1), CASP6(1), CASP7(2), CASP8(5), CASP9(1), DFFA(2), DFFB(2), DIABLO(1), ENDOG(1)	2348900	27	18	27	4	7	11	1	5	3	0	0.0592	0.939	1.000
60	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), B4GALT7(1), HS3ST1(1), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(2), XYLT1(7), XYLT2(4)	1117084	23	16	23	6	11	8	0	1	3	0	0.198	0.944	1.000
61	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), B4GALT7(1), HS3ST1(1), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(2), XYLT1(7), XYLT2(4)	1117084	23	16	23	6	11	8	0	1	3	0	0.198	0.944	1.000
62	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNG(2), IFNGR1(2), JAK1(2), JAK2(8), PTPRU(11), REG1A(3), STAT1(4)	1985131	33	18	33	6	11	8	1	8	4	1	0.0850	0.945	1.000
63	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(4), ESR2(5), ITPKA(1), PDE1A(3), PDE1B(2), PLCB1(10), PLCB2(3), PRL(1), TRH(3), VIP(1)	1918359	33	23	32	9	11	9	2	7	4	0	0.245	0.950	1.000
64	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CDK2(2), CUL1(8), NEDD8(1), RB1(7), SKP2(3), TFDP1(2)	1493358	26	16	25	8	4	10	1	7	4	0	0.379	0.954	1.000
65	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(3), SQLE(4)	564069	7	5	7	2	3	2	0	1	1	0	0.500	0.955	1.000
66	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(1), GGT1(3), SHMT1(1), SHMT2(3)	718711	8	8	8	5	2	0	0	3	3	0	0.836	0.958	1.000
67	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), CHPT1(1), LCMT1(1), LCMT2(6), METTL6(1), PCYT1A(7), PCYT1B(3), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(3), WBSCR22(2)	2440306	36	22	36	8	11	11	1	8	5	0	0.0912	0.963	1.000
68	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(3), GGPS1(1), SQLE(4)	751305	8	6	8	2	3	2	0	1	2	0	0.500	0.966	1.000
69	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(4), GABRA1(5), GABRA2(5), GABRA3(5), GABRA4(4), GABRA5(4), GABRA6(5), GPHN(7), NSF(2), UBQLN1(3)	2076100	44	24	44	12	10	10	7	12	5	0	0.218	0.968	1.000
70	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	18	AKT1(2), EIF2B5(3), EIF2S1(1), EIF2S2(2), EIF4E(1), EIF4EBP1(1), GSK3B(2), IGF1(2), IGF1R(10), INPPL1(12), PDPK1(1), PIK3R1(5), PPP2CA(3), PTEN(8), RPS6(1), RPS6KB1(2)	3030833	56	33	55	12	18	16	2	8	12	0	0.0716	0.970	1.000
71	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(3), MTMR2(3), MTMR6(3), PHPT1(2), THTPA(1), TPK1(2)	1114563	16	10	16	4	5	7	1	2	1	0	0.339	0.972	1.000
72	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(2), GOSR1(2), GOSR2(2), SNAP25(1), SNAP29(1), STX10(3), STX11(2), STX16(3), STX17(1), STX19(3), STX2(1), STX3(1), STX4(1), STX5(1), STX6(3), STX7(1), TSNARE1(5), USE1(2), VAMP4(1), VAMP5(1), VAMP7(2), VTI1B(1), YKT6(1)	2879545	41	23	41	8	15	15	1	8	2	0	0.0518	0.972	1.000
73	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(10), GNAS(11), GNGT1(3), PRKACA(1), PRKAR1A(1)	1139688	26	15	26	8	12	7	0	3	4	0	0.455	0.973	1.000
74	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(3), CYP2E1(3), NR1I3(3), PTGS1(5), PTGS2(2)	922911	16	12	16	4	7	5	1	2	1	0	0.280	0.973	1.000
75	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(4), GSS(1), IL8(1), NFKB1(5), NOX1(4), RELA(1), TNF(1), XDH(8)	1733277	25	15	25	7	5	10	1	6	3	0	0.292	0.976	1.000
76	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1R(2), C1S(3), C2(2), C3(14), C5(8), C6(6), C7(2), C8A(6), C8B(7), C9(3), MASP1(1)	3637229	55	31	54	12	18	11	2	18	5	1	0.0864	0.977	1.000
77	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL2(2), IFNAR1(4), IFNAR2(4), IFNB1(2), MAPK8(3), NFKB1(5), RELA(1), TNFRSF11A(2), TRAF6(4)	1925055	27	16	27	5	7	8	1	8	3	0	0.110	0.977	1.000
78	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(10), EP300(13), ESR1(4), MAPK1(2), MAPK3(1), PELP1(5)	2530202	35	22	34	7	11	10	1	2	11	0	0.0940	0.980	1.000
79	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), GPR109B(1), GPR161(2), GPR39(5), GPR45(4), GPR68(3), GPR75(3), GPR81(2)	1708922	22	16	22	6	12	3	2	4	1	0	0.165	0.980	1.000
80	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS3(1), DHRS7(1), DHRSX(2), ESCO2(1), MYST3(8), MYST4(10), NAT6(2), PNPLA3(1), SH3GLB1(1)	2868455	27	21	27	6	7	9	2	6	3	0	0.128	0.981	1.000
81	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(3), ALPL(3), ALPP(4), ALPPL2(4), FPGS(1), GGH(1), SPR(2)	1121941	18	13	18	7	10	3	0	2	3	0	0.451	0.981	1.000
82	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(3), ALOX15(2), ALOX15B(1), ALOX5(4), ALOX5AP(2), DPEP1(1), GGT1(3), LTA4H(4), PLA2G6(3), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(1)	2595660	36	24	36	7	15	8	3	8	2	0	0.0508	0.982	1.000
83	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(2), ST3GAL2(4), ST3GAL4(3), ST3GAL5(1), ST6GALNAC4(1), ST8SIA1(3)	977599	16	15	16	5	7	3	0	6	0	0	0.374	0.984	1.000
84	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(3), SNAP25(1)	565083	6	6	6	3	2	1	0	3	0	0	0.813	0.984	1.000
85	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3E(2), CD3G(2), ETV5(4), IFNG(2), IL12B(1), IL12RB1(4), IL12RB2(4), IL18R1(2), JAK2(8), JUN(2), MAP2K6(1), MAPK14(1), MAPK8(3), STAT4(3), TYK2(4)	3220385	44	23	43	9	9	13	3	11	8	0	0.0905	0.985	1.000
86	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(1), ACADM(1), ACADS(1), ACAT1(2), HADHA(2)	937112	7	5	6	2	2	3	0	0	2	0	0.381	0.986	1.000
87	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(19), ASAH1(2), CAMP(1), CASP3(1), CERK(3), CREB1(4), CREB3(2), CREB5(1), CXCL2(1), DAG1(5), EPHB2(6), GNAQ(1), ITPKA(1), ITPKB(5), JUN(2), MAP2K4(5), MAP2K7(12), MAPK1(2), MAPK10(1), MAPK8(3), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(7), MAPK9(3)	4906978	89	35	88	19	29	24	1	18	15	2	0.00947	0.986	1.000
88	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(4), JUN(2), KEAP1(5), MAPK1(2), MAPK14(1), MAPK8(3), NFE2L2(1)	1522301	18	13	18	5	5	8	0	4	1	0	0.279	0.987	1.000
89	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(1), ACADM(1), ACADS(1), ACSL1(2), ACSL3(5), ACSL4(2), CPT1A(4), CPT2(4), EHHADH(2), HADHA(2), SCP2(3), SLC25A20(1)	2911333	28	16	27	5	5	7	3	6	7	0	0.0782	0.987	1.000
90	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	CSNK2A1(4), GRB2(1), JAK2(8), JUN(2), MAP2K1(2), MAPK3(1), PIK3R1(5), PLCG1(10), RAF1(5), RASA1(9), SHC1(3), SOS1(3), STAT1(4), STAT3(6), STAT5A(1), STAT5B(2), THPO(2)	4808288	68	31	66	13	16	24	2	12	13	1	0.0185	0.988	1.000
91	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25A(2), CDC25B(2), CDC25C(2), CSK(2), GRB2(1), PTPRA(4)	1593950	14	11	14	3	5	5	0	1	3	0	0.200	0.989	1.000
92	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(3), CYP2A13(4), CYP2A6(1), CYP2A7(2), NAT1(1), NAT2(4), XDH(8)	1381142	23	17	22	6	7	12	1	3	0	0	0.141	0.989	1.000
93	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(2), CTH(2), GOT1(1), GOT2(2), LDHB(1), LDHC(1), MPST(1)	1164826	10	9	10	3	4	3	1	1	1	0	0.403	0.991	1.000
94	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(1), NDUFA8(1), NDUFB2(1), NDUFB7(1), NDUFS1(4), NDUFS2(2), NDUFV1(1)	1195543	12	11	12	3	1	5	1	3	2	0	0.468	0.991	1.000
95	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(4), GBA3(1), GGT1(3), SHMT1(1), SHMT2(3)	960448	13	11	13	6	5	2	0	3	3	0	0.642	0.992	1.000
96	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	BTK(2), CALM1(1), CALM2(2), CALM3(1), ELK1(2), GRB2(1), JUN(2), LYN(2), MAP2K1(2), MAP2K4(5), MAP2K7(12), MAP3K1(6), MAPK1(2), MAPK3(1), MAPK8(3), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), PAK2(5), PIK3R1(5), PLA2G4A(3), PLCG1(10), PPP3CA(3), PPP3CB(1), RAF1(5), SHC1(3), SOS1(3), SYK(3), VAV1(6)	7050126	117	41	116	24	39	40	1	18	19	0	0.00143	0.993	1.000
97	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(2), BAD(1), CASP9(1), GH1(1), GHR(3), NFKB1(5), PDPK1(1), PIK3R1(5), PPP2CA(3), RELA(1), YWHAH(1)	2069222	24	14	24	6	5	8	2	4	5	0	0.330	0.993	1.000
98	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(3), CBS(3), CTH(2), MUT(1)	842448	9	8	9	7	3	2	1	0	3	0	0.961	0.993	1.000
99	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(3), FUT1(1), FUT9(2), HEXA(1), HEXB(2), NAGA(3), ST3GAL1(2), ST3GAL2(4), ST3GAL4(3), ST8SIA1(3)	1751383	24	21	24	7	9	4	0	10	1	0	0.403	0.993	1.000
100	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3E(2), CD3G(2), HLA-A(6), ICAM1(2), ITGAL(5), ITGB2(5), PRF1(1)	1508849	25	18	24	8	8	5	2	4	6	0	0.523	0.993	1.000
101	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), CD8A(2), CSF3(1), IL11(2), IL3(1), IL8(1)	1057424	9	9	9	4	3	2	0	3	1	0	0.767	0.993	1.000
102	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(2), BFAR(1), BRAF(5), CAMP(1), CREB1(4), CREB3(2), CREB5(1), MAPK1(2), RAF1(5), SNX13(5), TERF2IP(3)	1964062	31	22	31	8	12	8	0	6	5	0	0.266	0.993	1.000
103	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	CDKN1A(1), EPOR(2), GRIN1(2), HIF1A(2), JAK2(8), NFKB1(5), RELA(1)	2191142	21	13	21	5	3	7	1	4	6	0	0.369	0.994	1.000
104	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IKBKB(3), IL1R1(3), IRAK1(4), MAP3K1(6), MAP3K14(2), MAP3K7(6), MYD88(1), NFKB1(5), RELA(1), TLR4(11), TNF(1), TNFAIP3(5), TNFRSF1A(2), TNFRSF1B(1), TRAF6(4)	4206804	55	32	54	13	15	12	5	16	7	0	0.107	0.995	1.000
105	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(5), PLCB1(10), RELA(1)	1430110	17	12	17	5	5	4	0	4	4	0	0.548	0.995	1.000
106	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1R(2), C1S(3), C2(2), C3(14), C5(8), C6(6), C7(2), C8A(6), C9(3)	3066302	47	28	47	12	16	10	2	14	4	1	0.197	0.995	1.000
107	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	CSNK2A1(4), ELK1(2), GRB2(1), JUN(2), MAP2K1(2), MAPK3(1), MAPK8(3), NGFR(4), PIK3R1(5), PLCG1(10), RAF1(5), SHC1(3), SOS1(3)	2926224	45	24	44	11	14	15	0	10	6	0	0.153	0.995	1.000
108	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CCNH(1), CDC25A(2), CDC25B(2), CDC25C(2), MNAT1(2), XPO1(3)	1496899	13	8	13	2	4	3	1	3	2	0	0.195	0.995	1.000
109	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACO1(8), ACSS1(6), ACSS2(3), FH(2), MDH1(3), SUCLA2(3)	2301548	27	17	26	8	8	6	3	5	5	0	0.316	0.995	1.000
110	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(2), JAK2(8), JAK3(3), PIAS1(3), PIAS3(1), PTPRU(11), REG1A(3), SOAT1(3)	2387331	35	19	35	8	11	9	0	8	6	1	0.219	0.995	1.000
111	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(12), GNA12(1), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAR2A(1), PRKAR2B(6)	1740622	27	19	27	7	5	13	1	6	2	0	0.164	0.995	1.000
112	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(2), GRB2(1), NTRK1(3), PIK3R1(5), PLCG1(10), SHC1(3), SOS1(3)	2312184	27	18	26	6	7	11	0	4	5	0	0.193	0.996	1.000
113	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAP3K14(2), MAPK14(1), MAPK8(3), NFKB1(5), RELA(1), TNFRSF13B(1), TNFRSF17(1), TRAF2(2), TRAF3(2), TRAF6(4)	2519767	22	16	22	4	5	4	1	9	3	0	0.242	0.996	1.000
114	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(5), ADC(1), AGMAT(2), ALDH18A1(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), AMD1(2), AOC2(4), AOC3(3), ARG1(2), ASL(3), ASS1(4), CPS1(14), GATM(2), MAOA(1), MAOB(3), NAGS(1), ODC1(2), OTC(2), SAT1(1), SMS(2), SRM(1)	5107474	78	36	78	14	23	23	5	22	5	0	0.00274	0.996	1.000
115	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS1(3), PAPSS2(2), SULT1A2(3), SULT1E1(3)	1057272	12	10	12	4	6	5	0	0	1	0	0.559	0.996	1.000
116	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(4), CREM(1), JUN(2), MAPK3(1), OPRK1(3), POLR2A(8), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6)	2223518	32	21	32	9	10	11	0	8	3	0	0.197	0.996	1.000
117	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), ACAT2(2), ACYP2(1), EHHADH(2), GCDH(3), HADHA(2), SDHB(3), SDS(1)	1352417	16	10	15	4	4	9	1	0	2	0	0.169	0.996	1.000
118	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(10), EP300(13), LPL(2), NCOA1(10), NCOA2(12), PPARG(1), RXRA(2)	3202156	50	26	50	11	9	23	3	6	9	0	0.0390	0.996	1.000
119	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD3E(2), CD3G(2), CD80(1), CD86(1), CTLA4(3), GRB2(1), HLA-DRA(3), HLA-DRB1(1), ICOS(1), ITK(4), PIK3R1(5), PTPN11(4)	1836044	28	23	27	9	6	8	2	7	5	0	0.569	0.996	1.000
120	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SRP19(1), SRP54(2), SRP72(4), SRPR(3)	1301838	11	9	11	3	4	4	0	2	1	0	0.521	0.997	1.000
121	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(4), IFNB1(2), JAK1(2), PTPRU(11), REG1A(3), STAT1(4), STAT2(3), TYK2(4)	2158365	33	20	33	7	14	7	0	8	3	1	0.133	0.997	1.000
122	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(1), DPYD(10), DPYS(1), ENPP1(1), ENPP3(2), PANK1(2), PANK2(2), PANK4(2), UPB1(1)	2413587	23	18	23	5	6	7	0	6	4	0	0.144	0.997	1.000
123	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), JAK1(2), JAK2(8), JAK3(3), PIAS3(1), PTPRU(11), REG1A(3), STAT3(6)	2636821	35	20	35	9	11	11	0	9	3	1	0.191	0.997	1.000
124	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(4), FADS2(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3)	1760099	27	19	27	7	11	5	1	9	1	0	0.284	0.997	1.000
125	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT1(2), B4GALT2(5), B4GALT5(3), FUT8(2), ST3GAL1(2), ST3GAL2(4), ST3GAL4(3)	1360747	22	19	21	6	9	7	0	5	1	0	0.306	0.997	1.000
126	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(14), CPT1A(4), LEPR(6), PRKAA1(1), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2)	2506064	33	17	33	8	14	7	2	5	5	0	0.174	0.998	1.000
127	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(4), AASS(2), KARS(2)	819834	8	5	8	3	2	4	1	1	0	0	0.626	0.998	1.000
128	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(8), EIF2AK4(3), EIF2B5(3), EIF2S1(1), EIF2S2(2), EIF5(3), GSK3B(2), PPP1CA(1)	2000110	23	18	23	6	4	9	1	8	1	0	0.297	0.998	1.000
129	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(3), PSMA6(2), PSMA7(3), PSMB2(1), PSMB3(1), PSMB4(1), PSMC3(5), RPN1(1), RPN2(3), UBE2A(2), UBE3A(4)	2243499	29	16	29	7	6	12	4	4	3	0	0.153	0.998	1.000
130	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	AKT1(2), CREB1(4), GRB2(1), MAPK1(2), MAPK3(1), MAPK7(6), MEF2B(3), MEF2C(2), MEF2D(5), NTRK1(3), PIK3R1(5), PLCG1(10), RPS6KA1(6), SHC1(3)	2891371	53	26	52	11	19	19	1	7	7	0	0.0277	0.998	1.000
131	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(3), HSD3B7(3), RDH11(1), RDH12(1)	830690	8	8	8	4	2	4	0	2	0	0	0.689	0.999	1.000
132	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(2), MAX(1), SP1(3), SP3(3), WT1(1)	1072760	10	9	10	6	3	4	0	1	2	0	0.780	0.999	1.000
133	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(3), PSMA6(2), PSMA7(3), PSMB2(1), PSMB3(1), PSMB4(1), PSMC2(3), PSMC3(5), PSMD1(3), PSMD11(1), PSMD12(1), PSMD2(9), PSMD6(1)	2756257	37	19	37	7	10	15	2	7	3	0	0.0664	0.999	1.000
134	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(3), LDLR(4), NR0B2(1), NR1H3(2), NR1H4(3), RXRA(2)	944252	15	13	15	6	7	2	0	4	2	0	0.520	0.999	1.000
135	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(2), ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH5(1), ADH6(2), ADH7(1), ADHFE1(6), DHRS3(1), DHRS7(1), DHRSX(2), ESCO2(1), MYST3(8), MYST4(10), NAT6(2), PNPLA3(1), SH3GLB1(1)	4332583	47	28	46	10	10	18	2	10	7	0	0.0456	0.999	1.000
136	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), ENO1(2), GPI(4), HK1(5), PFKL(4), PGK1(1), PKLR(4), TPI1(2)	1596632	24	16	24	8	9	10	1	4	0	0	0.274	0.999	1.000
137	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	EHHADH(2), HADHA(2), SDS(1)	840338	5	3	4	3	0	3	0	0	2	0	0.773	0.999	1.000
138	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP2(3), ACP6(2), ACPP(2), ACPT(1), ENPP1(1), ENPP3(2), FLAD1(2), LHPP(2), MTMR1(3), MTMR2(3), MTMR6(3), PHPT1(2), RFK(1), TYR(3)	2584727	30	20	30	9	7	12	2	6	3	0	0.299	0.999	1.000
139	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	CSNK2A1(4), ELK1(2), GRB2(1), IGF1(2), IGF1R(10), IRS1(6), JUN(2), MAP2K1(2), MAPK3(1), MAPK8(3), PIK3R1(5), PTPN11(4), RAF1(5), RASA1(9), SHC1(3), SOS1(3)	3911521	62	29	61	16	15	21	1	13	11	1	0.108	0.999	1.000
140	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), BCAT2(1), COASY(1), DPYD(10), DPYS(1), ENPP1(1), ENPP3(2), ILVBL(1), PANK1(2), PANK2(2), PANK4(2), PPCDC(1), UPB1(1), VNN1(1)	2998314	27	18	27	5	9	8	0	6	4	0	0.0609	0.999	1.000
141	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), ARG1(2), GLS(4), GLUD1(4)	955793	12	9	12	5	4	4	0	3	1	0	0.587	0.999	1.000
142	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), GPD2(3), NDUFA1(1), SDHA(5), SDHB(3), SDHC(1), UQCRC1(2)	1144498	16	12	16	5	6	5	1	2	2	0	0.372	0.999	1.000
143	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(2), CDC25B(2), CDKN1A(1), CHEK1(1), NEK1(3)	1222747	9	8	9	3	1	4	0	1	3	0	0.746	0.999	1.000
144	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(2), ACOX3(4), ELOVL2(1), ELOVL5(2), FADS1(2), FADS2(3), FASN(9), HADHA(2), HSD17B12(2), SCD(1)	2462512	28	15	26	8	10	6	1	6	5	0	0.298	0.999	1.000
145	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	ARF1(2), CCND1(1), CDK2(2), CDKN1A(1), CDKN2A(3), CFL1(1), E2F2(2), MDM2(3), NXT1(1), PRB1(2)	1265626	18	16	18	7	6	7	1	1	3	0	0.531	0.999	1.000
146	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(4), CYP11A1(2), CYP11B2(2), CYP17A1(2), HSD11B2(2), HSD3B1(1), HSD3B2(1)	1198061	14	10	14	5	4	3	1	5	1	0	0.485	0.999	1.000
147	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(5), CALCR(4), CALCRL(5), CD97(1), CRHR1(2), CRHR2(3), ELTD1(7), EMR1(10), EMR2(1), GLP1R(1), GLP2R(3), GPR64(6), LPHN1(6), LPHN2(9), LPHN3(10), SCTR(2), VIPR1(3), VIPR2(3)	4621431	81	37	81	20	19	25	6	25	6	0	0.0348	1.000	1.000
148	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	FH(2), MDH1(3), OGDH(6), SDHA(5), SUCLA2(3)	1619443	19	15	18	6	6	4	1	4	4	0	0.516	1.000	1.000
149	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(1), JUN(2), MAP2K1(2), MAPK1(2), MAPK3(1), NFKB1(5), PLCB1(10), RAF1(5), RELA(1), TNF(1)	2689071	30	19	30	9	9	7	0	9	5	0	0.432	1.000	1.000
150	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1R(2), C1S(3), C2(2), C3(14), C5(8), C6(6), C7(2), C8A(6), C9(3), MASP1(1), MASP2(2), MBL2(1)	3727605	51	28	51	13	17	12	2	15	4	1	0.151	1.000	1.000
151	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(3), GOT1(1), GOT2(2), TAT(1), TYR(3)	813195	10	10	10	6	3	3	0	3	1	0	0.888	1.000	1.000
152	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(4), BAIAP2(3), CASP1(1), CASP3(1), CASP7(2), CASP8(5), GAPDH(1), INSR(9), ITCH(3), MAGI1(14), MAGI2(9), RERE(15), WWP1(7), WWP2(8)	4138190	82	38	81	21	23	17	5	17	20	0	0.0971	1.000	1.000
153	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(5), LCT(7), PGM1(2), PYGL(3), PYGM(5), TPI1(2), TREH(2)	2312184	26	18	26	8	12	8	1	2	3	0	0.310	1.000	1.000
154	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(2), JAK2(8), JAK3(3), MAPK1(2), MAPK3(1), STAT3(6), TYK2(4)	2020547	26	19	26	8	5	10	0	6	4	1	0.477	1.000	1.000
155	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(2), CREBBP(10), DFFA(2), DFFB(2), HMGB2(1), PRF1(1), SET(2)	1831851	20	17	20	8	3	6	2	3	6	0	0.687	1.000	1.000
156	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(5), AMT(4), ATIC(4), GART(6), MTHFD1(2), MTHFD1L(2), MTHFD2(1), MTHFR(5), MTR(9), SHMT1(1), SHMT2(3), TYMS(1)	3096509	43	26	43	11	11	13	2	8	9	0	0.121	1.000	1.000
157	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(5), ALDH1A3(5), ALDH3A1(3), ALDH3B2(4), AOC2(4), AOC3(3), DDC(3), EPX(4), ESCO2(1), GOT1(1), GOT2(2), HPD(1), LPO(2), MAOA(1), MAOB(3), MPO(5), MYST3(8), MYST4(10), NAT6(2), PNPLA3(1), PRDX6(1), SH3GLB1(1), TAT(1), TPO(13)	5922836	84	41	84	22	25	22	3	27	7	0	0.0803	1.000	1.000
158	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(13), ATR(5), CDC25C(2), CHEK1(1), CHEK2(5), YWHAH(1)	2637446	27	20	26	8	8	9	2	3	4	1	0.513	1.000	1.000
159	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(3), CASP8(5), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(2)	1441241	15	14	15	6	5	3	1	5	1	0	0.583	1.000	1.000
160	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CALM2(2), CALM3(1), CCL2(1), CCR5(1), GNAQ(1), JUN(2), MAPK14(1), MAPK8(3), PLCG1(10), PTK2B(5)	2383778	28	18	27	8	12	8	0	8	0	0	0.247	1.000	1.000
161	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(4), ALAS1(1), ALAS2(4), FECH(4), PPOX(2), UROD(1), UROS(3)	1317535	19	17	19	7	5	4	1	7	2	0	0.686	1.000	1.000
162	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3)	1379699	26	19	26	10	7	6	0	9	4	0	0.589	1.000	1.000
163	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3)	1379699	26	19	26	10	7	6	0	9	4	0	0.589	1.000	1.000
164	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(6), LARS(2), LARS2(5), PDHA1(1), PDHA2(4), PDHB(2)	1737723	21	16	21	7	2	7	1	8	3	0	0.580	1.000	1.000
165	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	DUSP1(1), IKBKAP(2), IKBKB(3), MAP3K1(6), MAP3K14(2), NFKB1(5), RELA(1), TNFAIP3(5), TRAF3(2), TRAF6(4)	3148918	31	18	31	6	12	6	2	6	5	0	0.118	1.000	1.000
166	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(4), ALAS1(1), ALAS2(4), CPO(2), FECH(4), GATA1(1), HBB(1), UROD(1), UROS(3)	1368528	21	18	21	8	6	3	2	8	2	0	0.702	1.000	1.000
167	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(3), PSMA6(2), PSMA7(3), PSMB10(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB8(2)	1509924	17	8	17	5	5	6	2	2	2	0	0.408	1.000	1.000
168	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), ACAT2(2), ACOT11(3), ACYP2(1), DHRS3(1), DHRS7(1), DHRSX(2), EHHADH(2), ESCO2(1), FN3K(2), GCDH(3), HADHA(2), ITGB1BP3(2), MYST3(8), MYST4(10), NAT6(2), PNPLA3(1), SH3GLB1(1), YOD1(1)	4500446	47	27	46	10	11	21	3	7	5	0	0.0249	1.000	1.000
169	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(2), BAD(1), BAK1(2), BCL2(1), BCL2L11(1), BID(1), CASP8AP2(6), CASP9(1), CES1(6)	1947885	21	12	21	7	7	8	0	5	1	0	0.522	1.000	1.000
170	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	DNAJC3(1), EIF2S1(1), EIF2S2(2), MAP3K14(2), NFKB1(5), RELA(1)	1563960	12	8	12	3	3	2	0	5	2	0	0.631	1.000	1.000
171	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(1), MMP2(4), MMP9(6), RECK(5), TIMP2(1), TIMP3(2)	1298465	19	15	19	9	7	5	0	3	4	0	0.743	1.000	1.000
172	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	CSNK2A1(4), ELK1(2), GRB2(1), INSR(9), IRS1(6), JUN(2), MAP2K1(2), MAPK3(1), MAPK8(3), PIK3R1(5), PTPN11(4), RAF1(5), RASA1(9), SHC1(3), SLC2A4(1), SOS1(3)	4031518	60	30	59	16	15	20	1	10	13	1	0.0981	1.000	1.000
173	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(16), CR2(4), FCGR2B(1), HLA-DRA(3), HLA-DRB1(1), ICAM1(2), ITGAL(5), ITGB2(5), PTPRC(14)	2645466	52	31	49	15	16	16	0	14	6	0	0.207	1.000	1.000
174	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(4), ELK1(2), EPOR(2), GRB2(1), JAK2(8), JUN(2), MAP2K1(2), MAPK3(1), MAPK8(3), PLCG1(10), PTPN6(3), RAF1(5), SHC1(3), SOS1(3), STAT5A(1), STAT5B(2)	3720687	52	24	51	12	14	20	0	12	6	0	0.0828	1.000	1.000
175	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(1), CYP11A1(2), CYP11B1(2), CYP11B2(2), CYP17A1(2), CYP21A2(3), HSD11B2(2), HSD3B1(1), HSD3B2(1)	1525719	19	14	19	7	9	5	0	4	1	0	0.444	1.000	1.000
176	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(1), CYP11A1(2), CYP11B1(2), CYP11B2(2), CYP17A1(2), CYP21A2(3), HSD11B2(2), HSD3B1(1), HSD3B2(1)	1525719	19	14	19	7	9	5	0	4	1	0	0.444	1.000	1.000
177	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(2), CDK5R1(1), DRD1(2), DRD2(5), GRM1(17), PLCB1(10), PPP1CA(1), PPP2CA(3), PPP3CA(3), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6)	2766518	57	32	57	18	17	20	0	14	6	0	0.262	1.000	1.000
178	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(5), AGT(1), AGTR1(1), AGTR2(1), COL4A1(12), COL4A2(6), COL4A3(3), COL4A4(5), COL4A5(3), COL4A6(6), REN(2)	4413098	45	26	45	13	12	18	1	11	3	0	0.142	1.000	1.000
179	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(3), B3GALNT1(1), B3GALT5(1), FUT1(1), FUT9(2), HEXA(1), HEXB(2), NAGA(3), ST3GAL1(2), ST3GAL2(4), ST8SIA1(3)	1859330	23	21	23	9	8	4	1	9	1	0	0.688	1.000	1.000
180	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(2), ARHGAP5(5), CASP1(1), CASP10(3), CASP3(1), CASP8(5), CASP9(1), JUN(2), PRF1(1)	2234591	21	15	21	7	5	5	2	6	2	1	0.525	1.000	1.000
181	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(5), GUSB(2), UCHL1(2), UCHL3(3), UGDH(4), UGT1A1(1), UGT1A5(3), UGT2B15(1), UGT2B4(2)	3039052	23	14	23	6	6	10	0	3	4	0	0.224	1.000	1.000
182	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), HMOX1(3), IL10(1), IL10RB(1), JAK1(2), STAT1(4), STAT3(6), STAT5A(1), TNF(1)	2113380	21	15	21	8	4	9	0	6	1	1	0.568	1.000	1.000
183	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(4), GRB2(1), HBXIP(1), PTK2B(5), SHC1(3), SOS1(3)	1529747	17	11	17	5	3	7	0	3	4	0	0.424	1.000	1.000
184	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(4), IFNAR2(4), IFNB1(2), JAK1(2), STAT1(4), STAT2(3), TYK2(4)	1877009	24	13	24	8	8	7	0	5	3	1	0.463	1.000	1.000
185	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(3), ABP1(5), ACADM(1), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), AOC2(4), AOC3(3), DPYD(10), DPYS(1), EHHADH(2), GAD1(3), GAD2(3), HADHA(2), MLYCD(3), SMS(2), SRM(1), UPB1(1)	4674384	63	32	61	17	19	21	1	16	6	0	0.0706	1.000	1.000
186	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CALM2(2), CALM3(1), CDKN1A(1), GNAQ(1), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), PLCG1(10), PPP3CA(3), PPP3CB(1), SP1(3), SP3(3)	3602362	52	28	51	14	20	22	0	6	4	0	0.0616	1.000	1.000
187	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1), FUT1(1), FUT9(2), ST8SIA1(3)	1058584	7	7	7	4	2	2	0	3	0	0	0.833	1.000	1.000
188	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(8), AKT1(2), ATM(13), CDKN1A(1), CPB2(3), FHL2(2), HIC1(1), HIF1A(2), HSPA1A(1), IGFBP3(4), MAPK8(3), MDM2(3), NFKBIB(4), NQO1(2)	3459531	49	31	48	13	16	14	2	8	8	1	0.112	1.000	1.000
189	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), HADH(2), HADHA(2), HADHB(2), HSD17B4(1), MECR(3), PPT2(2)	1468900	13	7	12	4	1	4	1	3	4	0	0.388	1.000	1.000
190	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP2(3), ACPP(2), ACPT(1), ENPP1(1), ENPP3(2), FLAD1(2), RFK(1), TYR(3)	1659467	15	12	15	6	2	6	1	3	3	0	0.639	1.000	1.000
191	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(2), ABP1(5), AOC2(4), AOC3(3), CES1(6), CES7(5), DDHD1(7), ESCO2(1), LIPA(1), MYST3(8), MYST4(10), NAT6(2), PNPLA3(1), PRDX6(1), SH3GLB1(1)	4402118	57	30	56	14	15	21	3	15	3	0	0.0673	1.000	1.000
192	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(2), CD3E(2), CD3G(2), CD4(2), IFNG(2), IL12B(1), IL12RB1(4), IL12RB2(4), JAK2(8), STAT4(3), TYK2(4)	2542681	35	23	34	10	5	11	3	9	7	0	0.418	1.000	1.000
193	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(2), DHRS3(1), DHRS7(1), DHRSX(2), LCMT1(1), LCMT2(6), METTL6(1), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(3), WBSCR22(2)	2598272	29	19	29	9	6	10	1	7	5	0	0.331	1.000	1.000
194	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(3), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), CYP2C19(6), DHRS3(1), DHRS7(1), DHRSX(2), EHHADH(2), ESCO2(1), HADHA(2), MYST3(8), MYST4(10), NAT6(2), PNPLA3(1), SH3GLB1(1), YOD1(1)	5352035	60	31	59	15	15	19	2	16	8	0	0.0680	1.000	1.000
195	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(4), ASNS(3), ASRGL1(1), CA12(1), CA13(2), CA14(1), CA4(2), CA5B(1), CA6(3), CA7(2), CA8(1), CA9(2), CPS1(14), CTH(2), GLS(4), GLS2(4), GLUD1(4), GLUD2(6), GLUL(1), HAL(1)	3672081	59	33	59	16	17	14	3	19	6	0	0.182	1.000	1.000
196	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(2), CAMK2A(1), CAMK2G(4), CAMK4(4), CAMKK1(3), CREB1(4)	1996562	23	13	23	9	6	11	1	3	2	0	0.473	1.000	1.000
197	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC2(2), BIRC3(3), CASP3(1), CASP8(5), JUN(2), MAP2K4(5), MAP3K3(2), MAP3K7(6), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), NR2C2(2), RALBP1(4), TNF(1), TNFAIP3(5), TNFRSF1A(2), TNFRSF1B(1), TRAF2(2)	4705602	62	27	62	14	22	15	4	13	8	0	0.0371	1.000	1.000
198	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(4), EPX(4), LPO(2), MPO(5), MTHFR(5), PRDX6(1), SHMT1(1), SHMT2(3), TPO(13)	2009478	39	26	39	12	13	7	2	11	6	0	0.356	1.000	1.000
199	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(5), ALDH1A3(5), ALDH3A1(3), ALDH3B2(4), AOC2(4), AOC3(3), DDC(3), EPX(4), GOT1(1), GOT2(2), HPD(1), LPO(2), MAOA(1), MAOB(3), MPO(5), PRDX6(1), TAT(1), TPO(13)	3801791	61	32	61	19	19	15	1	22	4	0	0.280	1.000	1.000
200	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(5), AMT(4), ATIC(4), GART(6), MTHFD1(2), MTHFD1L(2), MTHFD2(1), MTHFR(5), MTR(9), SHMT1(1), SHMT2(3), TYMS(1)	3271806	43	26	43	12	11	13	2	8	9	0	0.173	1.000	1.000
201	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(3), ALOX12(3), ALOX15(2), ALOX5(4), CBR3(3), CYP4F2(4), CYP4F3(3), EPX(4), GGT1(3), LPO(2), LTA4H(4), MPO(5), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PRDX6(1), PTGES2(4), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(1), TPO(13)	4814601	85	41	84	25	33	19	4	22	7	0	0.148	1.000	1.000
202	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(3), GTF2A1(2), GTF2B(1), GTF2E1(4), GTF2F1(1), HDAC3(3), NCOA1(10), NCOA2(12), NCOA3(4), NCOR2(13), POLR2A(8), RARA(1), RXRA(2), TBP(1)	4311170	65	33	65	20	16	28	1	13	7	0	0.153	1.000	1.000
203	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(1), ACAT1(2), ACAT2(2), EHHADH(2), HADHA(2), HADHB(2), SDS(1)	1447076	12	6	11	5	1	7	0	1	3	0	0.572	1.000	1.000
204	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(4), ASNS(3), CA12(1), CA14(1), CA4(2), CA5B(1), CA6(3), CA7(2), CA8(1), CA9(2), CPS1(14), CTH(2), GLS(4), GLS2(4), GLUD1(4), GLUL(1), HAL(1)	3283838	50	29	50	15	13	13	3	15	6	0	0.317	1.000	1.000
205	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(19), AXIN1(7), BTRC(3), CCND1(1), CREBBP(10), CSNK2A1(4), CTBP1(2), CTNNB1(10), DVL1(2), FZD1(5), GSK3B(2), HDAC1(2), MAP3K7(6), NLK(4), PPARD(4), PPP2CA(3), TLE1(3), WIF1(2), WNT1(3)	5076758	92	44	89	27	28	21	5	14	22	2	0.208	1.000	1.000
206	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(3), ABP1(5), ACADL(1), ACADM(1), ACADSB(3), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), AOC2(4), AOC3(3), DPYD(10), DPYS(1), EHHADH(2), GAD1(3), GAD2(3), HADHA(2), MLYCD(3), SDS(1), SMS(2), UPB1(1)	5031893	74	34	72	22	21	27	1	18	7	0	0.107	1.000	1.000
207	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(2), CREB1(4), MAP2K1(2), MAP2K2(1), MAP2K3(1), MAP2K6(1), MAP3K1(6), MAPK1(2), MAPK14(1), MAPK3(1), NFKB1(5), PIK3R1(5), RB1(7), RELA(1), SP1(3)	2983877	42	21	41	10	8	17	0	8	9	0	0.173	1.000	1.000
208	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2(3), F2R(1), F5(8), F7(6), FGA(4), FGB(2), PROC(3), PROS1(5), SERPINC1(2), TFPI(3)	2839062	40	26	40	13	12	9	2	14	3	0	0.464	1.000	1.000
209	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(1), ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH6(2), ADH7(1), ADHFE1(6), AKR1C4(3), AKR1D1(1), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), BAAT(1), CEL(6), CYP27A1(1), CYP7A1(3), HADHB(2), SOAT2(1), SRD5A1(2), SRD5A2(2)	4022748	65	33	64	22	16	21	0	17	11	0	0.342	1.000	1.000
210	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(2), CD3G(2), CD8A(2), ICAM1(2), ITGAL(5), ITGB2(5), PTPRC(14)	1859732	34	21	32	13	10	8	1	10	5	0	0.640	1.000	1.000
211	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(1), ACADL(1), ACADM(1), ACADS(1), ACADSB(3), ACAT1(2), ACAT2(2), ACOX1(2), ACOX3(4), ACSL1(2), ACSL3(5), ACSL4(2), ACSL5(2), ACSL6(4), ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH5(1), ADH6(2), ADH7(1), ADHFE1(6), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), CPT1A(4), CPT1B(3), CPT1C(2), CPT2(4), CYP4A11(1), CYP4A22(1), EHHADH(2), GCDH(3), HADH(2), HADHA(2), HADHB(2), HSD17B4(1)	8478112	95	37	93	24	19	30	4	24	18	0	0.0315	1.000	1.000
212	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CLOCK(2), CRY1(1), CRY2(1), CSNK1E(6), PER1(3)	1463670	15	11	15	7	5	2	1	5	2	0	0.850	1.000	1.000
213	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	EHHADH(2), HADH(2), HADHA(2), HSD17B4(1), NTAN1(2), SIRT1(3), SIRT2(1), SIRT5(3), SIRT7(1), VNN2(1)	2052889	18	9	17	8	3	3	3	4	5	0	0.783	1.000	1.000
214	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	31	DUSP1(1), GORASP1(2), MAP2K4(5), MAP2K7(12), MAPK1(2), MAPK10(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(7), MAPK9(3), MAPKAPK5(2), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PIK3CD(8), PIK3R1(5), TRAF2(2), TRAF3(2), TRAF6(4)	5405678	82	35	81	18	33	20	3	14	12	0	0.00893	1.000	1.000
215	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO2(1), ENO3(2), FARS2(5), GOT1(1), GOT2(2), PAH(3), TAT(1), YARS(1)	1435911	18	14	18	9	7	5	0	5	1	0	0.820	1.000	1.000
216	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(3), CYB5R3(1), GCK(3), GFPT1(2), GNE(3), GNPDA1(3), HEXA(1), HEXB(2), HK1(5), HK2(5), HK3(3), PGM3(6), RENBP(2)	2926041	39	22	39	10	17	12	3	5	2	0	0.0911	1.000	1.000
217	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(1), HSPA1A(1), IFNG(2), IFNGR1(2), IFNGR2(1), IKBKB(3), JAK2(8), LIN7A(4), NFKB1(5), RB1(7), RELA(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), USH1C(1), WT1(1)	3014217	41	24	39	13	8	12	1	14	6	0	0.418	1.000	1.000
218	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(5), ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH6(2), ADH7(1), ADHFE1(6), ALDH1A3(5), ALDH3A1(3), ALDH3B2(4), AOC2(4), AOC3(3), AOX1(2), COMT(3), DBH(1), DCT(6), DDC(3), FAH(1), GOT1(1), GOT2(2), GSTZ1(3), HGD(2), HPD(1), MAOA(1), MAOB(3), PNMT(3), TAT(1), TH(1), TPO(13), TYR(3)	5490318	90	43	89	28	26	24	1	29	9	1	0.198	1.000	1.000
219	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(7), CHAT(1), CHKA(1), PCYT1A(7), PDHA1(1), PDHA2(4), PEMT(1), SLC18A3(5)	1204326	27	18	27	11	14	6	0	7	0	0	0.458	1.000	1.000
220	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), MDH1(3), ME1(2), PC(5), PDHA1(1), SLC25A1(1)	1599966	14	9	14	7	6	2	2	3	1	0	0.766	1.000	1.000
221	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(3), HK1(5), HK2(5), HK3(3), IMPA1(3), PGM1(2), PGM3(6), TGDS(2)	1768900	29	17	29	10	11	13	2	1	2	0	0.235	1.000	1.000
222	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(1), ACAD8(1), ACAD9(2), ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH5(1), ADH6(2), ADH7(1), ADHFE1(6), AKR1C4(3), AKR1D1(1), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), BAAT(1), CEL(6), CYP27A1(1), CYP7A1(3), HADHB(2), HSD3B7(3), LIPA(1), RDH11(1), RDH12(1), SLC27A5(4), SOAT1(3), SOAT2(1), SRD5A1(2), SRD5A2(2)	5487083	75	37	74	21	19	25	1	19	11	0	0.104	1.000	1.000
223	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(4), B3GAT2(1), B3GAT3(1), B4GALT7(1), CHPF(2), CHST11(1), CHST12(4), CHST13(1), CHST7(1), CHSY1(3), DSE(5), UST(5), XYLT1(7), XYLT2(4)	2381911	40	22	40	12	19	14	1	4	2	0	0.164	1.000	1.000
224	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), BTK(2), CALM1(1), CALM2(2), CALM3(1), CD79A(5), ELK1(2), GRB2(1), JUN(2), LYN(2), MAP2K1(2), MAP3K1(6), MAPK14(1), MAPK3(1), MAPK8(3), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), PLCG1(10), PPP3CA(3), PPP3CB(1), RAF1(5), SHC1(3), SOS1(3), SYK(3), VAV1(6)	6599171	93	37	92	26	35	32	1	15	10	0	0.0604	1.000	1.000
225	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(2), GTF2B(1), GTF2E1(4), GTF2E2(1), GTF2F1(1), GTF2F2(2), GTF2H1(1), GTF2H3(1), GTF2I(4), GTF2IRD1(7), TAF1(5), TAF10(1), TAF13(1), TAF1L(10), TAF2(5), TAF4(3), TAF4B(2), TAF5(2), TAF5L(4), TAF6(4), TAF6L(1), TAF7(4), TAF7L(3), TAF9B(2), TBPL2(3)	6251691	74	35	72	19	21	27	3	14	9	0	0.0675	1.000	1.000
226	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(12), COL4A2(6), COL4A3(3), COL4A4(5), COL4A5(3), COL4A6(6), F10(3), F11(3), F12(2), F2(3), F2R(1), F5(8), F8(11), F9(4), FGA(4), FGB(2), KLKB1(4), PROC(3), PROS1(5), SERPINC1(2), SERPING1(2)	7730670	92	42	92	27	21	30	4	28	9	0	0.132	1.000	1.000
227	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(10), DUSP1(1), EP300(13), IKBKB(3), IL1B(1), IL8(1), MAP2K3(1), MAP2K6(1), MAP3K14(2), MAP3K7(6), MAPK14(1), MYD88(1), NFKB1(5), NR3C1(4), RELA(1), TGFBR1(2), TGFBR2(6), TLR2(1), TNF(1)	5123280	61	32	61	18	13	17	4	14	13	0	0.316	1.000	1.000
228	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(14), C5(8), C6(6), C7(2), ICAM1(2), IL8(1), ITGA4(5), ITGAL(5), ITGB1(4), ITGB2(5), SELP(2), SELPLG(5), TNF(1), VCAM1(5)	4310301	65	32	64	22	24	16	0	20	5	0	0.274	1.000	1.000
229	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(2), EIF4E(1), FBL(2), LDHB(1), LDHC(1), MAPK14(1), NCL(6)	1532132	14	10	14	7	3	4	0	6	1	0	0.858	1.000	1.000
230	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(2), GPLD1(8), PGAP1(4), PIGA(1), PIGB(4), PIGC(2), PIGG(5), PIGK(1), PIGL(1), PIGM(4), PIGN(2), PIGO(1), PIGQ(1), PIGS(1), PIGT(2), PIGV(3), PIGX(2), PIGZ(2)	4149837	46	24	46	14	16	19	2	4	4	1	0.129	1.000	1.000
231	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(2), BAD(1), GRB2(1), IGF1R(10), IRS1(6), MAP2K1(2), MAPK1(2), MAPK3(1), PIK3R1(5), RAF1(5), SHC1(3), SOS1(3), YWHAH(1)	2901136	42	20	42	13	10	19	0	6	7	0	0.315	1.000	1.000
232	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(8), GABBR1(6), GPRC5B(4), GPRC5C(3), GPRC5D(1), GRM1(17), GRM2(10), GRM3(4), GRM4(2), GRM5(12), GRM7(9), GRM8(9)	3614831	85	45	85	29	38	16	5	20	6	0	0.188	1.000	1.000
233	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(2), BCL2(1), BCR(6), GRB2(1), JAK2(8), JUN(2), MAP2K1(2), MAP2K4(5), MAP3K1(6), MAPK3(1), MAPK8(3), PIK3R1(5), RAF1(5), SOS1(3), STAT1(4), STAT5A(1), STAT5B(2)	4482305	57	27	57	16	14	21	0	9	13	0	0.164	1.000	1.000
234	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(4), EGF(4), EGFR(7), ELK1(2), GRB2(1), JAK1(2), JUN(2), MAP2K1(2), MAP2K4(5), MAP3K1(6), MAPK3(1), MAPK8(3), PIK3R1(5), PLCG1(10), RAF1(5), RASA1(9), SHC1(3), SOS1(3), STAT1(4), STAT3(6), STAT5A(1)	6114199	85	37	83	25	22	27	1	17	16	2	0.173	1.000	1.000
235	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS3(1), DHRS7(1), DHRSX(2), HSD3B7(3), PON1(1), PON2(2), RDH11(1), RDH12(1)	1558128	12	12	12	9	4	4	1	2	1	0	0.954	1.000	1.000
236	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(13), CDC25A(2), CDC25B(2), CDC25C(2), CDK2(2), CHEK1(1), MYT1(9), RB1(7), YWHAH(1)	2917735	39	23	37	10	11	15	2	5	5	1	0.204	1.000	1.000
237	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), AGTR2(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2G(4), CDK5(2), F2(3), FYN(5), GNA11(4), GNAI1(1), GNGT1(3), GRB2(1), JAK2(8), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(3), MAPT(3), MYLK(7), PLCG1(10), PTK2B(5), RAF1(5), SHC1(3), SOS1(3), STAT1(4), STAT3(6), STAT5A(1)	7204857	95	38	94	27	29	34	3	20	9	0	0.0821	1.000	1.000
238	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(3), F11(3), F12(2), F13B(8), F2(3), F5(8), F7(6), F8(11), F9(4), FGA(4), FGB(2), LPA(10), PLAT(2), PLAU(2), PLG(8), SERPINB2(2), SERPINE1(2), SERPINF2(4), VWF(9)	6108030	93	40	93	27	26	28	5	24	10	0	0.133	1.000	1.000
239	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(1), CHST12(4), CHST13(1), PAPSS1(3), PAPSS2(2), SULT1A1(2), SULT1A2(3), SULT1E1(3)	1591150	20	14	20	8	9	6	1	2	2	0	0.581	1.000	1.000
240	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(2), ANKRD1(2), DUSP14(1), EIF4E(1), EIF4EBP1(1), IFNG(2), IFRD1(2), IL1R1(3), NR4A3(1), WDR1(1)	1854898	16	11	16	7	4	3	4	4	1	0	0.698	1.000	1.000
241	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(5), ALDOB(2), ALDOC(2), FBP1(1), FBP2(3), FPGT(3), GCK(3), GMDS(1), GMPPA(3), HK1(5), HK2(5), HK3(3), PFKFB3(2), PFKFB4(1), PFKM(2), PFKP(7), PMM1(1), PMM2(1), TPI1(2)	4157001	52	23	52	15	27	16	1	5	3	0	0.0641	1.000	1.000
242	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	IFNG(2), IKBKB(3), JUN(2), MAP3K1(6), MAP3K5(3), MAP4K5(3), MAPK14(1), MAPK8(3), NFKB1(5), RELA(1), TNFRSF9(3), TRAF2(2)	3375838	34	18	33	10	13	4	2	9	6	0	0.416	1.000	1.000
243	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(2), CARS2(1), CTH(2), GOT1(1), GOT2(2), LDHAL6B(2), LDHB(1), LDHC(1), MPST(1), SDS(1), SULT1B1(2), SULT1C4(1), SULT4A1(1)	2149557	18	13	18	8	7	5	1	3	2	0	0.651	1.000	1.000
244	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IFNA1(1), IFNB1(2), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(3), IRAK1(4), IRAK2(4), IRAK3(2), JUN(2), MAP2K3(1), MAP2K6(1), MAP3K1(6), MAP3K14(2), MAP3K7(6), MAPK14(1), MAPK8(3), MYD88(1), NFKB1(5), RELA(1), TGFB1(3), TGFB2(6), TGFB3(3), TNF(1), TOLLIP(1), TRAF6(4)	5128676	70	33	69	20	18	18	3	22	9	0	0.263	1.000	1.000
245	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(2), BIRC2(2), BIRC3(3), CASP10(3), CASP3(1), CASP7(2), CASP8(5), CASP9(1), DFFA(2), DFFB(2), PRF1(1), SCAP(6), SREBF1(2), SREBF2(5)	3132494	37	25	37	11	11	13	2	7	4	0	0.327	1.000	1.000
246	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(4), ELK1(2), GRB2(1), JAK1(2), JUN(2), MAP2K1(2), MAP2K4(5), MAP3K1(6), MAPK3(1), MAPK8(3), PDGFA(1), PDGFRA(3), PIK3R1(5), PLCG1(10), RAF1(5), RASA1(9), SHC1(3), SOS1(3), STAT1(4), STAT3(6), STAT5A(1)	5667776	78	36	76	24	21	27	1	12	15	2	0.204	1.000	1.000
247	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(2), BIRC2(2), BIRC3(3), CASP1(1), CASP10(3), CASP2(2), CASP3(1), CASP4(2), CASP6(1), CASP7(2), CASP8(5), CASP9(1), DFFA(2), DFFB(2), LMNA(5), LMNB1(1), LMNB2(2), PRF1(1)	3337798	38	24	38	11	12	13	4	6	3	0	0.259	1.000	1.000
248	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(2), BAD(1), CASP9(1), CDC42(1), ELK1(2), MAP2K1(2), MAPK3(1), NFKB1(5), PIK3R1(5), RAF1(5), RALBP1(4), RALGDS(7), RELA(1)	2868087	37	19	37	12	12	13	1	5	6	0	0.417	1.000	1.000
249	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPAT6(2), AGPS(2), CHPT1(1), ENPP2(3), ENPP6(2), PAFAH1B1(3), PAFAH1B2(2), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLD1(7), PLD2(10), PPAP2C(4)	4023692	63	27	63	18	19	23	3	11	7	0	0.123	1.000	1.000
250	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(4), ARG1(2), ASL(3), CKB(1), CKMT1A(2), CKMT1B(2), CKMT2(4), CPS1(14), GATM(2), GLUD1(4), NAGS(1), ODC1(2), OTC(2), PYCR1(2), SMS(2)	3022919	47	27	47	14	20	10	3	13	1	0	0.215	1.000	1.000
251	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	COPS5(1), CREB1(4), EDN1(3), EP300(13), HIF1A(2), JUN(2), NOS3(3), P4HB(2)	2932702	30	20	30	10	9	9	2	6	4	0	0.398	1.000	1.000
252	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	13	GALNT10(3), GALNT2(2), GALNT4(1), GALNT6(2), GALNT8(3), GALNT9(2), ST3GAL1(2), ST3GAL2(4), ST3GAL4(3)	2285186	22	16	22	9	10	2	1	7	2	0	0.746	1.000	1.000
253	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(14), ACACB(10), FASN(9), MCAT(1), OXSM(3)	2721333	37	19	36	12	13	9	1	6	8	0	0.345	1.000	1.000
254	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), EHHADH(2), HADHA(2), SDS(1)	2103088	31	20	30	13	7	9	0	9	6	0	0.628	1.000	1.000
255	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(9), EXT2(3), EXTL1(3), EXTL2(2), EXTL3(5), GLCE(2), HS3ST1(1), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(2), HS3ST5(4), HS6ST1(1), HS6ST2(1), HS6ST3(4), NDST1(7), NDST2(5), NDST3(4), NDST4(9)	3575992	69	36	68	22	21	26	1	15	6	0	0.248	1.000	1.000
256	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(2), DLG4(3), EPHB2(6), F2(3), F2RL1(1), F2RL2(1), JUN(2), MAPK1(2), MAPK7(6), MAPK8(3), MYEF2(4), PLD1(7), PLD2(10), PLD3(5), PTK2(7), RAF1(5), RASAL1(1), TEC(3), VAV1(6)	4735723	77	32	77	23	24	26	4	15	8	0	0.145	1.000	1.000
257	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(5), GUSB(2), UGDH(4), UGP2(1), UGT1A1(1), UGT1A5(3), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), XYLB(4)	4536383	37	23	37	11	6	16	1	9	5	0	0.276	1.000	1.000
258	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(1), GHR(3), GRB2(1), INSR(9), IRS1(6), JAK2(8), MAP2K1(2), MAPK1(2), MAPK3(1), PIK3R1(5), PLCG1(10), PTPN6(3), RAF1(5), RPS6KA1(6), SHC1(3), SLC2A4(1), SOCS1(1), SOS1(3), STAT5A(1), STAT5B(2)	5337887	73	33	72	21	23	26	1	12	11	0	0.120	1.000	1.000
259	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(2), ELK1(2), FPR1(1), GNA15(2), GNGT1(3), MAP2K1(2), MAP2K2(1), MAP2K3(1), MAP2K6(1), MAP3K1(6), MAPK1(2), MAPK14(1), MAPK3(1), NCF1(1), NCF2(1), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NFKB1(5), PAK1(4), PIK3C2G(3), PLCB1(10), PPP3CA(3), PPP3CB(1), RAF1(5), RELA(1)	6635366	90	40	90	29	28	29	1	18	14	0	0.235	1.000	1.000
260	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(5), CALM1(1), CALM2(2), CALM3(1), CAPN2(2), CAPNS1(1), CAPNS2(1), EP300(13), HDAC1(2), HDAC2(2), MEF2D(5), NFATC1(8), NFATC2(6), PPP3CA(3), PPP3CB(1)	4211893	53	24	53	15	21	17	0	10	5	0	0.106	1.000	1.000
261	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(3), ALOX12(3), ALOX12B(3), ALOX15(2), ALOX15B(1), ALOX5(4), CBR3(3), CYP2B6(2), CYP2C18(3), CYP2C19(6), CYP2E1(3), CYP2J2(2), CYP2U1(2), CYP4A11(1), CYP4A22(1), CYP4F2(4), CYP4F3(3), DHRS4(1), EPHX2(3), GGT1(3), GPX3(1), GPX4(1), GPX6(1), GPX7(2), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PTGES2(4), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(1)	6714782	97	39	96	24	36	26	5	23	7	0	0.0204	1.000	1.000
262	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(4), CRK(1), GNAI1(1), GNAQ(1), GNGT1(3), MAP2K1(2), MAPK1(2), MAPK3(1), NFKB1(5), PIK3C2G(3), PIK3R1(5), PLCG1(10), PTK2(7), PTK2B(5), PXN(1), RAF1(5), RELA(1)	4421258	57	26	56	18	15	15	3	12	12	0	0.378	1.000	1.000
263	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(2), AVP(3), CABIN1(5), CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(2), HDAC5(4), IGF1(2), IGF1R(10), INSR(9), MAP2K6(1), MAPK14(1), MAPK7(6), MEF2B(3), MEF2C(2), MEF2D(5), MYOD1(3), NFATC1(8), NFATC2(6), PIK3R1(5), PPP3CA(3), PPP3CB(1), YWHAH(1)	5619131	87	34	87	28	33	29	2	14	9	0	0.0878	1.000	1.000
264	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(2), APAF1(2), ATM(13), BAD(1), BCL2(1), BID(1), CASP3(1), CASP6(1), CASP7(2), CASP9(1), EIF2S1(1), PTK2(7), PXN(1), STAT1(4), TLN1(11)	4604924	49	26	48	13	19	17	4	4	4	1	0.116	1.000	1.000
265	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22RA1(1), IL22RA2(1), JAK1(2), JAK2(8), JAK3(3), SOCS3(3), STAT1(4), STAT3(6), STAT5A(1), STAT5B(2), TYK2(4)	3177458	35	22	35	12	10	11	1	8	4	1	0.467	1.000	1.000
266	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(3), APC(19), AXIN1(7), BTRC(3), CTNNB1(10), DLL1(3), DVL1(2), FZD1(5), GSK3B(2), NOTCH1(12), PSEN1(1), WNT1(3)	3678052	70	38	68	27	23	14	2	14	15	2	0.602	1.000	1.000
267	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(3), HK1(5), HK2(5), HK3(3), IMPA1(3), ISYNA1(2), PGM1(2), PGM3(6), TGDS(2)	2012483	31	18	31	12	12	13	2	2	2	0	0.316	1.000	1.000
268	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(5), ACY3(1), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(3), AOC2(4), AOC3(3), CARM1(2), DDC(3), HAL(1), HARS(3), HARS2(2), HDC(2), HNMT(1), LCMT1(1), LCMT2(6), MAOA(1), MAOB(3), METTL6(1), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(3), PRPS1(1), PRPS2(1), UROC1(3), WBSCR22(2)	6852862	82	39	82	24	18	25	3	27	9	0	0.136	1.000	1.000
269	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ARG1(2), ASL(3), ASS1(4), CKB(1), CKMT1A(2), CKMT1B(2), CKMT2(4), CPS1(14), DAO(5), EPRS(6), GATM(2), GLUD1(4), GLUD2(6), GOT1(1), GOT2(2), LAP3(1), NOS1(15), NOS3(3), OTC(2), P4HA1(1), P4HA2(6), P4HA3(1), PYCR1(2), RARS(2)	6207337	93	44	92	28	35	23	5	24	6	0	0.151	1.000	1.000
270	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(12), COL4A2(6), COL4A3(3), COL4A4(5), COL4A5(3), COL4A6(6), P4HB(2), SLC23A1(4), SLC23A2(5), SLC2A1(3), SLC2A3(2)	4383647	51	24	51	22	14	20	0	11	6	0	0.619	1.000	1.000
271	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	19	B2M(2), HLA-A(6), ITGB1(4), KLRC1(2), KLRC2(2), KLRD1(2), MAP2K1(2), MAPK3(1), PAK1(4), PIK3R1(5), PTK2B(5), PTPN6(3), SYK(3), VAV1(6)	2840433	47	34	46	16	7	17	1	12	10	0	0.573	1.000	1.000
272	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CLOCK(2), CRY1(1), CRY2(1), CSNK1E(6), NPAS2(5), NR1D1(2), PER1(3), PER2(9), PER3(6)	2941956	37	20	37	12	12	7	3	10	5	0	0.423	1.000	1.000
273	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(10), EP300(13), HDAC3(3), IKBKB(3), NFKB1(5), RELA(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF6(4)	3864051	43	24	43	14	12	12	2	7	10	0	0.417	1.000	1.000
274	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(4), AGT(1), AGTR2(1), EDN1(3), EDNRA(1), EGF(4), EGFR(7), JUN(2), NFKB1(5), PLCG1(10), RELA(1)	3404234	39	17	38	14	12	6	2	16	3	0	0.532	1.000	1.000
275	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), BCL2(1), CASP8(5), MAP2K1(2), MAP2K4(5), MAP3K1(6), MAPK1(2), MAPK3(1), MAPK8(3), NFKB1(5), NSMAF(8), RAF1(5), RELA(1), SMPD1(3), TNFRSF1A(2), TRAF2(2)	3546801	52	25	52	18	18	14	1	10	9	0	0.376	1.000	1.000
276	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(2), CCR2(2), CCR3(4), CCR5(1), CD4(2), IFNG(2), IFNGR1(2), IFNGR2(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL18R1(2), IL4R(1), TGFB1(3), TGFB2(6), TGFB3(3)	3456099	40	25	40	16	10	9	2	13	6	0	0.669	1.000	1.000
277	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(2), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP10(3), CASP3(1), CASP6(1), CASP7(2), CASP8(5), CASP9(1), DFFA(2), DFFB(2), GAS2(1), LMNA(5), MAP3K14(2), NFKB1(5), RELA(1), SPTAN1(10), TNFRSF10A(2), TNFRSF10B(2), TNFRSF25(1), TNFSF10(2), TRAF2(2)	5781027	59	34	59	16	17	14	2	17	9	0	0.263	1.000	1.000
278	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(5), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(3), AOC2(4), AOC3(3), DDC(3), HAL(1), HARS(3), HDC(2), HNMT(1), MAOA(1), MAOB(3), PRPS1(1), PRPS2(1)	4232597	58	32	58	21	15	17	2	19	5	0	0.451	1.000	1.000
279	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREB1(4), CREBBP(10), EP300(13), NCOA3(4), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), RARA(1), RXRA(2)	3568668	49	26	49	18	13	20	1	4	11	0	0.382	1.000	1.000
280	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(13), ANAPC11(1), ANAPC2(2), ANAPC5(2), ANAPC7(1), BTRC(3), CDC16(1), CDC20(2), CDC23(4), CDC26(1), CDC27(2), CUL1(8), CUL2(3), CUL3(4), FBXW11(5), FBXW7(8), FZR1(3), ITCH(3), SKP2(3), SMURF1(1), SMURF2(1), TCEB1(1), UBA1(1), UBE2D3(1), UBE2E3(3), WWP1(7), WWP2(8)	6993782	92	33	83	24	26	32	1	19	14	0	0.0840	1.000	1.000
281	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(2), ARFGAP1(1), ARFGAP3(4), ARFGEF2(11), CLTA(2), COPA(4), GBF1(8), GPLD1(8), KDELR1(1)	2798357	41	23	41	14	12	19	1	8	1	0	0.273	1.000	1.000
282	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	CDC42(1), CREB1(4), DAXX(3), DDIT3(3), ELK1(2), GRB2(1), HSPB1(1), MAP2K4(5), MAP2K6(1), MAP3K1(6), MAP3K5(3), MAP3K7(6), MAP3K9(5), MAPK14(1), MAPKAPK5(2), MAX(1), MEF2B(3), MEF2C(2), MEF2D(5), MKNK1(1), PLA2G4A(3), SHC1(3), STAT1(4), TGFB1(3), TGFB2(6), TGFB3(3), TGFBR1(2), TRAF2(2)	6354165	82	34	82	26	27	27	3	13	12	0	0.196	1.000	1.000
283	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(2), ALOX5(4), CYP1A2(3), CYP2C18(3), CYP2C19(6), CYP2E1(3), CYP2J2(2), CYP3A4(1), CYP3A43(3), CYP3A7(2), HSD3B7(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), RDH11(1), RDH12(1)	4138275	52	27	52	16	18	17	2	12	3	0	0.201	1.000	1.000
284	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2A1(1), AP2M1(4), ARF1(2), BAD(1), BTK(2), EEA1(2), GRASP(1), GSK3A(1), GSK3B(2), LYN(2), PDPK1(1), PFKL(4), PFKM(2), PFKP(7), PLCG1(10), PRKCE(5), RAB5A(2), RPS6KB1(2), VAV2(8)	4331992	61	25	60	20	23	21	3	11	3	0	0.209	1.000	1.000
285	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), CDC42(1), CREB1(4), CREB3(2), CREB5(1), DUSP1(1), DUSP10(3), EEF2K(6), EIF4E(1), ELK1(2), HSPB1(1), IL1R1(3), MAP2K3(1), MAP2K4(5), MAP2K6(1), MAP3K10(6), MAP3K4(8), MAP3K5(3), MAP3K7(6), MAPK1(2), MAPK13(1), MAPK14(1), MAPKAPK5(2), MKNK1(1), MYEF2(4), NFKB1(5), NR2C2(2), TRAF6(4)	5767065	79	33	78	26	24	27	5	12	11	0	0.228	1.000	1.000
286	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(8), DLD(2), DLST(1), FH(2), IDH3A(1), IDH3B(3), IDH3G(2), MDH1(3), PC(5), PCK1(2), SDHA(5), SDHB(3), SUCLA2(3), SUCLG1(1), SUCLG2(3)	3554735	44	23	43	17	20	10	0	10	4	0	0.482	1.000	1.000
287	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRA2A(2), ADRA2C(3), ADRB1(3), ADRB2(3), CHRM1(2), CHRM2(6), CHRM3(5), CHRM4(2), CHRM5(2), DRD1(2), DRD2(5), DRD3(6), DRD4(1), DRD5(7), HRH1(3), HRH2(4), HTR1A(5), HTR1B(4), HTR1D(3), HTR1E(1), HTR1F(3), HTR2A(1), HTR2B(4), HTR2C(3), HTR4(3), HTR5A(3), HTR6(1), HTR7(4)	4432171	103	39	101	33	36	27	7	26	7	0	0.0923	1.000	1.000
288	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(4), CFL1(1), GNAQ(1), GNAS(11), GNGT1(3), LIMK1(3), MAP2K1(2), MAPK1(2), MAPK3(1), MYL2(1), NOX1(4), PIK3C2G(3), PLCB1(10), PPP1R12B(6), PTK2(7), RAF1(5), ROCK2(2)	4386342	67	34	67	20	23	15	3	14	12	0	0.362	1.000	1.000
289	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(2), AKT1(2), ANGPTL2(4), DAG1(5), DGKA(3), ETFA(1), GCA(2), ITGA9(7), ITPKA(1), ITPKB(5), ITPR1(17), ITPR2(14), ITPR3(16), MAP2K1(2), MAPK1(2), MAPK3(1), NR1I3(3), PAK1(4), PDE3A(6), PDE3B(8), PI3(1), PIK3C2G(3), PIK3CD(8), PIK3R1(5), RIPK3(2), SGCB(2), VASP(2)	8116166	128	47	127	34	41	35	8	25	18	1	0.0247	1.000	1.000
290	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	234	ADCYAP1R1(5), ADORA1(4), ADORA2B(1), ADORA3(2), ADRA1A(7), ADRA1B(3), ADRA2A(2), ADRA2B(2), ADRA2C(3), ADRB1(3), ADRB2(3), AGTR1(1), AGTR2(1), AVPR1A(6), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(2), C5AR1(1), CALCR(4), CALCRL(5), CCKAR(1), CCKBR(4), CHRM1(2), CHRM2(6), CHRM3(5), CHRM4(2), CHRM5(2), CNR1(5), CRHR1(2), CRHR2(3), CTSG(2), CYSLTR1(2), DRD1(2), DRD2(5), DRD3(6), DRD4(1), DRD5(7), EDNRA(1), F2(3), F2R(1), F2RL1(1), F2RL2(1), FPR1(1), FSHB(1), FSHR(12), GABBR1(6), GABBR2(4), GABRA1(5), GABRA2(5), GABRA3(5), GABRA4(4), GABRA5(4), GABRA6(5), GABRB2(2), GABRB3(3), GABRE(4), GABRG2(8), GABRG3(2), GABRP(3), GABRQ(5), GABRR1(5), GABRR2(4), GALR1(2), GALR2(1), GALR3(1), GH1(1), GH2(2), GHR(3), GHSR(3), GLP1R(1), GLP2R(3), GLRA1(2), GLRA2(1), GLRA3(2), GLRB(5), GNRHR(3), GPR156(2), GPR35(2), GPR50(4), GPR83(4), GRIA1(9), GRIA2(13), GRIA3(5), GRIA4(2), GRID1(12), GRID2(10), GRIK1(6), GRIK2(9), GRIK3(7), GRIK4(5), GRIK5(5), GRIN1(2), GRIN2A(6), GRIN2B(8), GRIN2C(3), GRIN3A(5), GRIN3B(2), GRM1(17), GRM2(10), GRM3(4), GRM4(2), GRM5(12), GRM6(8), GRM7(9), GRM8(9), GRPR(2), HCRTR1(2), HCRTR2(2), HRH1(3), HRH2(4), HRH3(1), HRH4(1), HTR1A(5), HTR1B(4), HTR1D(3), HTR1E(1), HTR1F(3), HTR2A(1), HTR2B(4), HTR2C(3), HTR4(3), HTR5A(3), HTR6(1), HTR7(4), LEPR(6), LHCGR(7), LTB4R(1), LTB4R2(2), MAS1(1), MC2R(2), MC3R(2), MC4R(4), MC5R(5), MCHR1(3), MCHR2(3), MTNR1A(2), MTNR1B(2), NMUR1(2), NMUR2(1), NPBWR1(8), NPBWR2(5), NPFFR1(1), NPFFR2(3), NPY1R(1), NPY2R(1), NR3C1(4), NTSR1(4), OPRD1(2), OPRK1(3), OXTR(4), P2RX2(4), P2RX3(2), P2RX4(1), P2RX5(2), P2RY1(4), P2RY10(3), P2RY13(3), P2RY14(2), P2RY4(2), P2RY6(3), P2RY8(4), PARD3(8), PPYR1(5), PRL(1), PRLHR(2), PRLR(1), PRSS1(2), PRSS3(2), PTAFR(2), PTGDR(4), PTGER2(2), PTGER3(2), PTGER4(1), PTGFR(3), PTH2R(4), RXFP1(4), RXFP2(5), SCTR(2), SSTR1(9), SSTR2(2), SSTR3(3), SSTR4(6), SSTR5(2), TAAR1(2), TAAR2(1), TAAR5(2), TAAR6(5), TACR1(3), TACR2(1), TACR3(6), TBXA2R(6), THRA(2), THRB(3), TRHR(3), TRPV1(5), TSHB(1), TSHR(6), UTS2R(1), VIPR1(3), VIPR2(3)	38066156	718	99	713	228	254	217	31	176	40	0	9.57e-05	1.000	1.000
291	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	190	ACTB(4), ACTN1(3), ACTN2(11), ACTN3(1), ACTN4(1), AKT1(2), AKT2(2), AKT3(3), ARHGAP5(5), BAD(1), BCAR1(4), BCL2(1), BIRC2(2), BIRC3(3), BRAF(5), CAPN2(2), CAV1(2), CCND1(1), CCND3(2), CDC42(1), CHAD(1), COL11A1(12), COL11A2(4), COL1A1(5), COL1A2(13), COL2A1(8), COL3A1(6), COL4A1(12), COL4A2(6), COL4A4(5), COL4A6(6), COL5A1(13), COL5A2(5), COL5A3(4), COL6A1(5), COL6A2(8), COL6A3(20), COL6A6(17), COMP(1), CRK(1), CTNNB1(10), DIAPH1(3), DOCK1(10), EGF(4), EGFR(7), ELK1(2), ERBB2(5), FARP2(3), FLNA(10), FLNB(3), FLNC(13), FLT1(5), FN1(18), FYN(5), GRB2(1), GRLF1(7), GSK3B(2), HGF(12), IBSP(2), IGF1(2), IGF1R(10), ILK(1), ITGA1(3), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(6), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(4), ITGA8(2), ITGA9(7), ITGAV(3), ITGB1(4), ITGB3(3), ITGB4(9), ITGB5(2), ITGB6(1), ITGB7(2), ITGB8(7), JUN(2), KDR(4), LAMA1(16), LAMA2(18), LAMA3(8), LAMA4(9), LAMA5(14), LAMB1(6), LAMB2(9), LAMB3(12), LAMB4(7), LAMC1(5), LAMC2(5), LAMC3(9), MAP2K1(2), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(3), MAPK9(3), MET(4), MYL2(1), MYL7(1), MYLK(7), MYLK2(2), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PARVB(3), PARVG(1), PDGFA(1), PDGFB(3), PDGFC(3), PDGFD(2), PDGFRA(3), PDGFRB(7), PDPK1(1), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PIP5K1C(5), PPP1CA(1), PPP1CC(2), PPP1R12A(1), PRKCG(4), PTEN(8), PTK2(7), PXN(1), RAC2(1), RAC3(1), RAF1(5), RAP1A(2), RAP1B(3), RAPGEF1(5), RELN(17), ROCK1(7), ROCK2(2), SHC1(3), SHC2(2), SHC3(4), SOS1(3), SOS2(3), SPP1(1), THBS1(7), THBS2(6), THBS3(4), THBS4(3), TLN1(11), TLN2(18), TNC(10), TNN(11), TNR(12), TNXB(22), VASP(2), VAV1(6), VAV2(8), VAV3(6), VCL(2), VEGFC(3), VTN(3), VWF(9), ZYX(2)	63922767	888	98	879	397	309	277	23	186	90	3	0.936	1.000	1.000
292	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	200	ABI2(3), ACTN1(3), ACTN2(11), ACTN3(1), ACTN4(1), APC(19), APC2(6), ARAF(5), ARHGEF1(2), ARHGEF12(3), ARHGEF4(3), ARHGEF6(9), ARHGEF7(8), ARPC1A(3), ARPC4(1), BAIAP2(3), BCAR1(4), BDKRB1(1), BDKRB2(2), BRAF(5), CD14(1), CDC42(1), CFL1(1), CHRM1(2), CHRM2(6), CHRM3(5), CHRM4(2), CHRM5(2), CRK(1), CSK(2), CYFIP1(5), CYFIP2(4), DIAPH1(3), DIAPH2(3), DIAPH3(11), DOCK1(10), EGF(4), EGFR(7), F2(3), F2R(1), FGD1(5), FGD3(7), FGF1(2), FGF10(4), FGF11(1), FGF12(4), FGF13(4), FGF14(4), FGF17(2), FGF18(2), FGF2(1), FGF20(1), FGF21(1), FGF22(3), FGF23(1), FGF5(1), FGF6(4), FGF7(1), FGF9(5), FGFR1(8), FGFR2(5), FGFR3(1), FGFR4(6), FN1(18), GIT1(2), GNA12(1), GNG12(1), GRLF1(7), GSN(5), IQGAP1(5), IQGAP2(6), IQGAP3(7), ITGA1(3), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(6), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(4), ITGA8(2), ITGA9(7), ITGAD(4), ITGAE(2), ITGAL(5), ITGAM(4), ITGAV(3), ITGAX(5), ITGB1(4), ITGB2(5), ITGB3(3), ITGB4(9), ITGB5(2), ITGB6(1), ITGB7(2), ITGB8(7), LIMK1(3), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MOS(3), MSN(3), MYH10(16), MYH14(9), MYH9(13), MYL2(1), MYL7(1), MYLK(7), MYLK2(2), NCKAP1(5), NCKAP1L(7), NRAS(1), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PDGFA(1), PDGFB(3), PDGFRA(3), PDGFRB(7), PFN2(2), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PIP4K2A(3), PIP4K2B(1), PIP4K2C(1), PIP5K1A(2), PIP5K1C(5), PPP1CA(1), PPP1CC(2), PPP1R12A(1), PPP1R12B(6), PTK2(7), PXN(1), RAC2(1), RAC3(1), RAF1(5), RDX(2), ROCK1(7), ROCK2(2), RRAS(1), RRAS2(1), SCIN(2), SLC9A1(6), SOS1(3), SOS2(3), SSH1(6), SSH2(11), SSH3(2), TIAM1(13), TIAM2(15), TMSL3(1), VAV1(6), VAV2(8), VAV3(6), VCL(2), WASF1(3), WASF2(2), WASL(1)	47351266	687	93	679	284	247	193	20	143	82	2	0.808	1.000	1.000
293	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(10), ADCY2(7), ADCY3(1), ADCY4(3), ADCY7(10), ADCY8(10), ADCY9(5), ADORA2B(1), ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRB1(3), ADRB2(3), AGTR1(1), ATP2A1(2), ATP2A2(3), ATP2A3(4), ATP2B1(6), ATP2B2(8), ATP2B3(8), ATP2B4(2), AVPR1A(6), AVPR1B(1), BDKRB1(1), BDKRB2(2), CACNA1A(9), CACNA1B(11), CACNA1C(18), CACNA1D(12), CACNA1E(21), CACNA1F(1), CACNA1G(8), CACNA1H(8), CACNA1I(10), CACNA1S(10), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2G(4), CAMK4(4), CCKAR(1), CCKBR(4), CD38(1), CHRM1(2), CHRM2(6), CHRM3(5), CHRM5(2), CHRNA7(1), CYSLTR1(2), DRD1(2), EDNRA(1), EGFR(7), ERBB2(5), ERBB3(16), ERBB4(16), F2R(1), GNA11(4), GNA14(2), GNA15(2), GNAQ(1), GNAS(11), GRIN1(2), GRIN2A(6), GRIN2C(3), GRM1(17), GRM5(12), GRPR(2), HRH1(3), HRH2(4), HTR2A(1), HTR2B(4), HTR2C(3), HTR4(3), HTR5A(3), HTR6(1), HTR7(4), ITPKA(1), ITPKB(5), ITPR1(17), ITPR2(14), ITPR3(16), LHCGR(7), LTB4R2(2), MYLK(7), MYLK2(2), NOS1(15), NOS3(3), NTSR1(4), OXTR(4), P2RX2(4), P2RX3(2), P2RX4(1), P2RX5(2), PDE1A(3), PDE1B(2), PDE1C(2), PDGFRA(3), PDGFRB(7), PHKA1(5), PHKA2(7), PHKG1(2), PHKG2(2), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PLCD1(1), PLCD3(6), PLCE1(8), PLCG1(10), PLCG2(6), PLCZ1(2), PPID(3), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), PTAFR(2), PTGER3(2), PTGFR(3), PTK2B(5), RYR1(27), RYR2(35), RYR3(32), SLC25A4(2), SLC25A5(1), SLC25A6(4), SLC8A1(4), SLC8A2(2), SLC8A3(5), SPHK1(3), TACR1(3), TACR2(1), TACR3(6), TBXA2R(6), TNNC1(3), TRHR(3), TRPC1(1), VDAC1(1), VDAC3(1)	46630599	759	92	749	274	287	235	35	136	65	1	0.0162	1.000	1.000
294	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(10), ADCY2(7), ADCY3(1), ADCY4(3), ADCY5(7), ADCY6(5), ADCY7(10), ADCY8(10), ADCY9(5), ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRB1(3), ADRB2(3), ANXA6(2), ARRB1(3), ARRB2(1), ATP1A4(10), ATP1B3(2), ATP2A2(3), ATP2A3(4), ATP2B1(6), ATP2B2(8), ATP2B3(8), CACNA1A(9), CACNA1B(11), CACNA1C(18), CACNA1D(12), CACNA1E(21), CACNA1S(10), CACNB1(1), CALM1(1), CALM2(2), CALM3(1), CALR(3), CAMK1(1), CAMK2A(1), CAMK2G(4), CAMK4(4), CASQ1(2), CASQ2(1), CHRM1(2), CHRM2(6), CHRM3(5), CHRM4(2), CHRM5(2), GJA1(8), GJA4(3), GJA5(2), GJB3(2), GJB6(2), GNA11(4), GNAI2(3), GNAI3(4), GNAO1(1), GNAQ(1), GNAZ(6), GNB2(3), GNB4(3), GNG12(1), GNG7(2), GNGT1(3), GRK4(1), ITPR1(17), ITPR2(14), ITPR3(16), KCNB1(4), KCNJ3(5), KCNJ5(2), MIB1(2), NME7(1), PLCB3(6), PRKACA(1), PRKACB(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(5), PRKCG(4), PRKCH(5), PRKCQ(2), PRKD1(4), RGS1(1), RGS10(2), RGS11(1), RGS14(1), RGS16(2), RGS17(1), RGS18(2), RGS19(1), RGS2(2), RGS20(1), RGS3(11), RGS5(1), RGS6(7), RGS7(1), RGS9(4), RYR1(27), RYR2(35), RYR3(32), SLC8A1(4), SLC8A3(5), USP5(3), YWHAH(1), YWHAQ(1)	32700480	538	91	534	210	207	153	26	98	54	0	0.180	1.000	1.000
295	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	245	ACVR1B(6), ACVR1C(3), AKT1(2), AKT2(2), AKT3(3), ARRB1(3), ARRB2(1), ATF4(1), BDNF(1), BRAF(5), CACNA1A(9), CACNA1B(11), CACNA1C(18), CACNA1D(12), CACNA1E(21), CACNA1F(1), CACNA1G(8), CACNA1H(8), CACNA1I(10), CACNA1S(10), CACNA2D1(6), CACNA2D2(5), CACNA2D3(6), CACNA2D4(5), CACNB1(1), CACNB2(11), CACNB4(3), CACNG2(1), CACNG3(3), CACNG4(2), CACNG5(2), CACNG6(1), CACNG7(4), CASP3(1), CD14(1), CDC25B(2), CDC42(1), CRK(1), DAXX(3), DDIT3(3), DUSP1(1), DUSP10(3), DUSP14(1), DUSP16(3), DUSP2(2), DUSP4(1), DUSP5(3), DUSP6(1), DUSP8(1), DUSP9(2), ECSIT(1), EGF(4), EGFR(7), ELK1(2), ELK4(3), FAS(2), FGF1(2), FGF10(4), FGF11(1), FGF12(4), FGF13(4), FGF14(4), FGF17(2), FGF18(2), FGF2(1), FGF20(1), FGF21(1), FGF22(3), FGF23(1), FGF5(1), FGF6(4), FGF7(1), FGF9(5), FGFR1(8), FGFR2(5), FGFR3(1), FGFR4(6), FLNA(10), FLNB(3), FLNC(13), GNA12(1), GNG12(1), GRB2(1), IKBKB(3), IL1B(1), IL1R1(3), IL1R2(1), JUN(2), MAP2K1(2), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(1), MAP2K7(12), MAP3K1(6), MAP3K10(6), MAP3K12(4), MAP3K13(3), MAP3K14(2), MAP3K2(1), MAP3K3(2), MAP3K4(8), MAP3K5(3), MAP3K6(5), MAP3K7(6), MAP4K1(2), MAP4K2(3), MAP4K3(1), MAP4K4(4), MAPK1(2), MAPK10(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(6), MAPK8(3), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(7), MAPK9(3), MAPKAPK3(1), MAPKAPK5(2), MAPT(3), MAX(1), MEF2C(2), MKNK1(1), MOS(3), NF1(9), NFATC2(6), NFATC4(10), NFKB1(5), NFKB2(3), NLK(4), NR4A1(1), NRAS(1), NTF3(1), NTRK1(3), NTRK2(4), PAK1(4), PAK2(5), PDGFA(1), PDGFB(3), PDGFRA(3), PDGFRB(7), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PPM1A(3), PPM1B(8), PPP3CA(3), PPP3CB(1), PPP3R2(1), PPP5C(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), PTPN5(1), PTPN7(2), PTPRR(2), RAC2(1), RAC3(1), RAF1(5), RAP1A(2), RAP1B(3), RAPGEF2(6), RASA1(9), RASA2(4), RASGRF1(2), RASGRF2(7), RASGRP1(4), RASGRP2(4), RASGRP3(2), RASGRP4(3), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KA4(2), RPS6KA6(7), RRAS(1), RRAS2(1), SOS1(3), SOS2(3), STK3(2), STK4(2), STMN1(2), TAOK1(5), TAOK2(8), TAOK3(4), TGFB1(3), TGFB2(6), TGFB3(3), TGFBR1(2), TGFBR2(6), TNF(1), TNFRSF1A(2), TRAF2(2), TRAF6(4), ZAK(3)	49314469	714	89	704	246	251	220	24	138	79	2	0.0105	1.000	1.000
296	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	125	ABL1(2), ABLIM1(3), ABLIM2(3), ABLIM3(3), ARHGEF12(3), CDC42(1), CDK5(2), CFL1(1), DCC(16), DPYSL2(1), DPYSL5(4), EFNA1(1), EFNA2(1), EFNA5(2), EFNB1(1), EFNB2(3), EFNB3(3), EPHA1(8), EPHA2(4), EPHA3(10), EPHA4(6), EPHA5(13), EPHA6(12), EPHA7(3), EPHA8(8), EPHB1(13), EPHB2(6), EPHB3(6), EPHB4(4), EPHB6(4), FES(4), FYN(5), GNAI1(1), GNAI2(3), GNAI3(4), GSK3B(2), ITGB1(4), L1CAM(2), LIMK1(3), LRRC4C(3), MAPK1(2), MAPK3(1), MET(4), NCK1(3), NCK2(2), NFAT5(4), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NGEF(5), NRAS(1), NRP1(8), NTN1(3), NTNG1(6), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PLXNA1(13), PLXNA2(11), PLXNA3(9), PLXNB1(7), PLXNB2(8), PLXNB3(6), PLXNC1(7), PPP3CA(3), PPP3CB(1), PPP3R2(1), PTK2(7), RAC2(1), RAC3(1), RASA1(9), RGS3(11), ROBO1(10), ROBO2(11), ROBO3(4), ROCK1(7), ROCK2(2), SEMA3A(4), SEMA3B(2), SEMA3D(6), SEMA3E(7), SEMA3F(5), SEMA3G(3), SEMA4A(3), SEMA4B(3), SEMA4C(4), SEMA4D(5), SEMA4F(2), SEMA5A(10), SEMA5B(5), SEMA6A(5), SEMA6B(2), SEMA6C(4), SEMA6D(8), SEMA7A(1), SLIT1(5), SLIT2(14), SLIT3(7), SRGAP1(10), SRGAP2(4), SRGAP3(5), UNC5A(6), UNC5B(4), UNC5C(8), UNC5D(4)	33923516	536	88	532	225	161	150	41	126	57	1	0.804	1.000	1.000
297	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(7), CD36(2), CD44(5), CHAD(1), COL11A1(12), COL11A2(4), COL1A1(5), COL1A2(13), COL2A1(8), COL3A1(6), COL4A1(12), COL4A2(6), COL4A4(5), COL4A6(6), COL5A1(13), COL5A2(5), COL5A3(4), COL6A1(5), COL6A2(8), COL6A3(20), COL6A6(17), DAG1(5), FN1(18), FNDC1(8), FNDC3A(5), FNDC4(2), GP5(2), GP6(3), HMMR(4), HSPG2(15), IBSP(2), ITGA1(3), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(6), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(4), ITGA8(2), ITGA9(7), ITGAV(3), ITGB1(4), ITGB3(3), ITGB4(9), ITGB5(2), ITGB6(1), ITGB7(2), ITGB8(7), LAMA1(16), LAMA2(18), LAMA3(8), LAMA4(9), LAMA5(14), LAMB1(6), LAMB2(9), LAMB3(12), LAMB4(7), LAMC1(5), LAMC2(5), LAMC3(9), RELN(17), SDC1(1), SDC2(1), SDC3(2), SDC4(2), SPP1(1), SV2A(5), SV2C(4), THBS1(7), THBS2(6), THBS3(4), THBS4(3), TNC(10), TNN(11), TNR(12), TNXB(22), VTN(3), VWF(9)	38878552	550	87	546	250	199	149	14	130	57	1	0.941	1.000	1.000
298	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(4), CHAD(1), COL11A1(12), COL11A2(4), COL17A1(4), COL1A1(5), COL1A2(13), COL2A1(8), COL3A1(6), COL4A1(12), COL4A2(6), COL4A4(5), COL4A6(6), COL5A1(13), COL5A2(5), COL5A3(4), COL6A1(5), COL6A2(8), COL6A3(20), COL6A6(17), COMP(1), DSC1(2), DSC2(4), DSC3(4), DSG1(3), DSG2(1), DSG3(6), DSG4(2), FN1(18), GJA1(8), GJA10(1), GJA4(3), GJA5(2), GJA8(1), GJA9(2), GJB3(2), GJB6(2), GJC2(2), GJD2(3), GJD4(4), IBSP(2), INA(3), ITGA6(2), ITGB4(9), KRT1(1), KRT10(3), KRT12(3), KRT13(6), KRT14(1), KRT15(1), KRT16(3), KRT17(1), KRT18(2), KRT2(6), KRT20(2), KRT23(1), KRT24(1), KRT25(2), KRT27(6), KRT28(4), KRT3(2), KRT31(2), KRT32(3), KRT33A(5), KRT33B(3), KRT34(1), KRT35(2), KRT36(3), KRT37(3), KRT38(1), KRT39(2), KRT4(1), KRT40(1), KRT5(2), KRT6A(5), KRT6B(1), KRT6C(2), KRT7(3), KRT71(1), KRT72(5), KRT73(6), KRT74(3), KRT75(2), KRT76(1), KRT77(2), KRT78(3), KRT79(2), KRT8(3), KRT81(2), KRT82(2), KRT83(2), KRT84(3), KRT85(1), KRT86(1), LAMA1(16), LAMA2(18), LAMA3(8), LAMA4(9), LAMA5(14), LAMB1(6), LAMB2(9), LAMB3(12), LAMB4(7), LAMC1(5), LAMC2(5), LAMC3(9), LMNA(5), LMNB1(1), LMNB2(2), NES(3), PRPH(1), RELN(17), SPP1(1), THBS1(7), THBS2(6), THBS3(4), THBS4(3), TNC(10), TNN(11), TNR(12), TNXB(22), VIM(2), VTN(3), VWF(9)	43146495	606	86	603	263	217	173	17	148	50	1	0.819	1.000	1.000
299	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	ALCAM(6), CADM1(7), CADM3(4), CD2(2), CD22(1), CD226(2), CD274(1), CD276(3), CD34(2), CD4(2), CD40(1), CD40LG(4), CD58(1), CD6(5), CD80(1), CD86(1), CD8A(2), CD8B(1), CDH1(12), CDH15(1), CDH2(8), CDH3(5), CDH4(10), CDH5(4), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(3), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(3), CLDN23(3), CLDN4(4), CLDN6(1), CLDN9(3), CNTN1(9), CNTN2(4), CNTNAP1(9), CNTNAP2(13), CTLA4(3), ESAM(6), GLG1(5), HLA-A(6), HLA-C(3), HLA-DMA(1), HLA-DMB(2), HLA-DOA(1), HLA-DPA1(2), HLA-DPB1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(3), HLA-DRB1(1), HLA-E(2), HLA-F(4), HLA-G(2), ICAM1(2), ICAM2(2), ICAM3(2), ICOS(1), ITGA4(5), ITGA6(2), ITGA8(2), ITGA9(7), ITGAL(5), ITGAM(4), ITGAV(3), ITGB1(4), ITGB2(5), ITGB7(2), ITGB8(7), JAM3(2), L1CAM(2), MADCAM1(2), MAG(6), MPZ(2), NCAM1(2), NCAM2(9), NEGR1(3), NEO1(7), NFASC(8), NLGN1(7), NLGN2(5), NLGN3(6), NRCAM(5), NRXN1(15), NRXN2(10), NRXN3(10), OCLN(1), PDCD1(1), PDCD1LG2(1), PTPRC(14), PTPRF(8), PTPRM(14), PVR(2), PVRL1(1), PVRL2(3), PVRL3(3), SDC1(1), SDC2(1), SDC3(2), SDC4(2), SELE(3), SELL(4), SELP(2), SELPLG(5), SIGLEC1(9), VCAM1(5), VCAN(20)	25434697	451	86	444	168	142	143	15	109	42	0	0.111	1.000	1.000
300	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	129	ACTB(4), ACTN1(3), ACTN2(11), ACTN3(1), ACTN4(1), AKT1(2), AKT2(2), AKT3(3), AMOTL1(3), ASH1L(16), CASK(2), CDC42(1), CGN(7), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(3), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(3), CLDN23(3), CLDN4(4), CLDN6(1), CLDN9(3), CSDA(4), CSNK2A1(4), CSNK2A2(1), CTNNA1(4), CTNNA2(11), CTNNA3(4), CTNNB1(10), CTTN(2), EPB41(6), EPB41L1(3), EPB41L2(8), EPB41L3(14), EXOC3(3), EXOC4(4), GNAI1(1), GNAI2(3), GNAI3(4), HCLS1(1), IGSF5(2), INADL(5), JAM3(2), LLGL1(7), LLGL2(4), MAGI1(14), MAGI2(9), MAGI3(3), MLLT4(14), MPDZ(14), MPP5(1), MYH1(5), MYH10(16), MYH11(8), MYH13(11), MYH14(9), MYH15(5), MYH2(10), MYH3(13), MYH4(11), MYH6(8), MYH7(11), MYH7B(7), MYH8(8), MYH9(13), MYL2(1), MYL7(1), NRAS(1), OCLN(1), PARD3(8), PARD6B(1), PARD6G(2), PPM1J(2), PPP2CA(3), PPP2CB(2), PPP2R1A(4), PPP2R1B(4), PPP2R2A(2), PPP2R2B(3), PPP2R2C(3), PPP2R3A(5), PPP2R3B(5), PPP2R4(2), PRKCD(3), PRKCE(5), PRKCG(4), PRKCH(5), PRKCI(5), PRKCQ(2), PTEN(8), RAB13(2), RAB3B(2), RRAS(1), RRAS2(1), SPTAN1(10), SYMPK(5), TJAP1(1), TJP1(6), TJP2(5), TJP3(2), YES1(2), ZAK(3)	33526160	505	82	502	159	174	152	16	112	50	1	0.00979	1.000	1.000
301	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ACTA2(5), ADCY1(10), ADCY2(7), ADCY3(1), ADCY4(3), ADCY5(7), ADCY6(5), ADCY7(10), ADCY8(10), ADCY9(5), ARRB1(3), ARRB2(1), ATF4(1), ATF5(3), ATP2A2(3), ATP2A3(4), CALCA(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2G(4), CNN1(1), CORIN(7), CREB3(2), CRHR1(2), DGKZ(1), ETS2(1), GABPA(1), GABPB2(1), GBA2(1), GJA1(8), GNAQ(1), GNB2(3), GNB4(3), GNG12(1), GNG7(2), GNGT1(3), GRK4(1), GUCA2A(1), GUCY1A3(9), IGFBP1(2), IGFBP2(1), IGFBP3(4), IL1B(1), ITPR1(17), ITPR2(14), ITPR3(16), JUN(2), MIB1(2), MYL2(1), MYL4(1), MYLK2(2), NFKB1(5), NOS1(15), NOS3(3), OXT(1), OXTR(4), PDE4B(2), PLCB3(6), PLCD1(1), PLCG1(10), PLCG2(6), PRKACA(1), PRKACB(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(5), PRKCH(5), PRKCQ(2), PRKD1(4), RAMP2(1), RAMP3(3), RGS1(1), RGS10(2), RGS11(1), RGS14(1), RGS16(2), RGS17(1), RGS18(2), RGS19(1), RGS2(2), RGS20(1), RGS3(11), RGS5(1), RGS6(7), RGS7(1), RGS9(4), RYR1(27), RYR2(35), RYR3(32), SLC8A1(4), SP1(3), TNXB(22), USP5(3), YWHAH(1), YWHAQ(1)	30109693	454	81	451	184	175	117	16	105	41	0	0.478	1.000	1.000
302	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTA2(5), ACTN2(11), ACTN3(1), ACTN4(1), DMD(23), FAM48A(5), MYBPC1(2), MYBPC2(5), MYBPC3(2), MYH3(13), MYH6(8), MYH7(11), MYH8(8), MYL2(1), MYL3(1), MYL4(1), MYOM1(1), NEB(25), TMOD1(1), TNNI2(3), TNNT1(2), TNNT2(2), TPM1(1), TPM3(1), TPM4(2), TTN(234), VIM(2)	23874148	373	81	371	130	102	115	20	113	20	3	0.266	1.000	1.000
303	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1(4), ACVR1B(6), ACVR2B(2), AMHR2(2), BMP2(2), BMP7(2), BMPR1A(1), BMPR1B(2), BMPR2(10), CCL11(1), CCL15(1), CCL18(2), CCL2(1), CCL20(1), CCL23(1), CCL25(1), CCL5(1), CCL7(1), CCL8(2), CCR1(2), CCR2(2), CCR3(4), CCR5(1), CCR8(1), CD27(2), CD40(1), CD40LG(4), CD70(1), CLCF1(1), CNTF(2), CNTFR(1), CSF1R(6), CSF2RA(5), CSF2RB(4), CSF3(1), CSF3R(5), CX3CL1(4), CX3CR1(3), CXCL16(2), CXCL2(1), CXCL9(1), CXCR6(1), EDA(1), EDAR(3), EGF(4), EGFR(7), EPOR(2), FAS(2), FLT1(5), FLT3(6), FLT4(6), GDF5(4), GH1(1), GH2(2), GHR(3), HGF(12), IFNA1(1), IFNA10(1), IFNA16(1), IFNA17(3), IFNA5(2), IFNA7(2), IFNA8(1), IFNAR1(4), IFNAR2(4), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), IFNK(1), IFNW1(1), IL10(1), IL10RB(1), IL11(2), IL11RA(2), IL12B(1), IL12RB1(4), IL12RB2(4), IL13(1), IL13RA1(2), IL15RA(1), IL17B(1), IL17RA(4), IL17RB(1), IL18R1(2), IL18RAP(2), IL1B(1), IL1R1(3), IL1R2(1), IL1RAP(3), IL20(1), IL20RA(3), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(3), IL25(1), IL26(1), IL28A(2), IL28B(3), IL2RA(1), IL2RG(3), IL3(1), IL3RA(4), IL4R(1), IL5RA(1), IL6ST(2), IL7R(3), IL8(1), INHBA(5), INHBB(6), INHBC(1), INHBE(1), KDR(4), KIT(6), KITLG(3), LEPR(6), LIF(1), LIFR(5), LTA(2), LTBR(1), MET(4), NGFR(4), OSM(1), OSMR(2), PDGFB(3), PDGFC(3), PDGFRA(3), PDGFRB(7), PF4V1(1), PRL(1), PRLR(1), TGFB1(3), TGFB2(6), TGFB3(3), TGFBR1(2), TGFBR2(6), TNF(1), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(1), TNFRSF13B(1), TNFRSF17(1), TNFRSF19(3), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TNFRSF25(1), TNFRSF8(2), TNFRSF9(3), TNFSF10(2), TNFSF15(1), TNFSF18(2), TNFSF8(1), TPO(13), TSLP(2), VEGFC(3), XCL1(1), XCR1(3)	30448516	405	80	399	176	124	121	20	96	42	2	0.821	1.000	1.000
304	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(3), ADCY1(10), ADCY2(7), ADCY3(1), ADCY4(3), ADCY5(7), ADCY6(5), ADCY7(10), ADCY8(10), ADCY9(5), ADK(1), ADSL(2), ADSS(3), ADSSL1(6), AK5(2), AK7(2), ALLC(3), AMPD1(3), AMPD2(5), AMPD3(7), APRT(2), ATIC(4), CANT1(3), DCK(1), DGUOK(1), ENPP1(1), ENPP3(2), ENTPD1(3), ENTPD3(3), ENTPD4(6), ENTPD6(1), ENTPD8(4), GART(6), GDA(1), GMPR(2), GMPR2(2), GMPS(2), GUCY1A2(3), GUCY1A3(9), GUCY1B3(5), GUCY2C(6), GUCY2D(8), GUCY2F(7), GUK1(2), IMPDH1(1), IMPDH2(1), NME6(2), NME7(1), NPR1(6), NPR2(3), NT5C(1), NT5C1A(1), NT5C1B(4), NT5C2(5), NUDT2(2), NUDT9(1), PAPSS1(3), PAPSS2(2), PDE10A(1), PDE11A(2), PDE1A(3), PDE1C(2), PDE2A(6), PDE3B(8), PDE4A(3), PDE4B(2), PDE4C(1), PDE5A(3), PDE6G(1), PDE7A(5), PDE7B(2), PDE8A(6), PDE8B(2), PDE9A(2), PFAS(1), PKLR(4), PKM2(2), PNPT1(2), POLA1(4), POLA2(2), POLD1(7), POLD3(1), POLE(12), POLE2(1), POLE3(1), POLE4(1), POLR1A(5), POLR1C(2), POLR1D(1), POLR2A(8), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(10), POLR3B(3), POLR3G(1), POLR3K(1), PPAT(1), PRIM1(1), PRIM2(3), PRPS1(1), PRPS1L1(1), PRPS2(1), PRUNE(3), RRM1(3), RRM2(2), RRM2B(2), XDH(8)	28328903	364	78	363	128	123	126	13	76	26	0	0.109	1.000	1.000
305	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	141	APC(19), APC2(6), AXIN1(7), AXIN2(3), BTRC(3), CACYBP(1), CAMK2A(1), CAMK2G(4), CCND1(1), CCND3(2), CER1(2), CHD8(7), CREBBP(10), CSNK1A1L(2), CSNK1E(6), CSNK2A1(4), CSNK2A2(1), CTBP1(2), CTBP2(3), CTNNB1(10), CTNNBIP1(1), CUL1(8), CXXC4(1), DAAM1(7), DAAM2(4), DKK1(4), DKK2(2), DKK4(1), DVL1(2), DVL2(2), DVL3(4), EP300(13), FBXW11(5), FZD1(5), FZD10(7), FZD2(2), FZD3(4), FZD4(2), FZD5(1), FZD6(5), FZD7(1), FZD8(2), GSK3B(2), JUN(2), LEF1(4), LRP5(8), LRP6(2), MAP3K7(6), MAPK10(1), MAPK8(3), MAPK9(3), MMP7(1), NFAT5(4), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NKD1(5), NKD2(1), NLK(4), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PORCN(2), PPARD(4), PPP2CA(3), PPP2CB(2), PPP2R1A(4), PPP2R1B(4), PPP2R2A(2), PPP2R2B(3), PPP2R2C(3), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRICKLE1(9), PRICKLE2(11), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), PSEN1(1), RAC2(1), RAC3(1), ROCK1(7), ROCK2(2), RUVBL1(4), SENP2(2), SFRP1(2), SFRP2(2), SFRP4(2), SIAH1(1), SMAD2(4), SMAD3(2), SOX17(3), TBL1X(2), TBL1XR1(2), TCF7(2), TCF7L1(3), TCF7L2(4), VANGL1(2), WIF1(2), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(4), WNT3A(1), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(1), WNT9A(1), WNT9B(2)	27511843	428	78	422	144	145	133	16	77	54	3	0.0257	1.000	1.000
306	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA1(4), ADORA2B(1), ADORA3(2), ADRA1A(7), ADRA1B(3), ADRA1D(2), ADRA2A(2), ADRA2C(3), ADRB1(3), ADRB2(3), AGTR1(1), AGTR2(1), AVPR1A(6), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(2), CCBP2(2), CCKAR(1), CCKBR(4), CCR1(2), CCR10(1), CCR2(2), CCR3(4), CCR5(1), CCR8(1), CCRL1(3), CHML(2), CHRM1(2), CHRM2(6), CHRM3(5), CHRM4(2), CHRM5(2), CMKLR1(1), CNR1(5), CX3CR1(3), DRD1(2), DRD2(5), DRD3(6), DRD4(1), DRD5(7), EDNRA(1), F2R(1), F2RL1(1), F2RL2(1), FPR1(1), FSHR(12), GALR1(2), GALR2(1), GALR3(1), GALT(1), GHSR(3), GPR17(1), GPR173(2), GPR174(1), GPR27(2), GPR3(3), GPR35(2), GPR37(2), GPR37L1(3), GPR4(2), GPR50(4), GPR6(6), GPR83(4), GPR85(1), GPR87(3), GRPR(2), HCRTR1(2), HCRTR2(2), HRH1(3), HRH2(4), HRH3(1), HTR1A(5), HTR1B(4), HTR1D(3), HTR1E(1), HTR1F(3), HTR2A(1), HTR2B(4), HTR2C(3), HTR4(3), HTR5A(3), HTR6(1), HTR7(4), LHCGR(7), LTB4R(1), MAS1(1), MC3R(2), MC4R(4), MC5R(5), MTNR1A(2), MTNR1B(2), NMUR1(2), NMUR2(1), NPY1R(1), NPY2R(1), NTSR1(4), OPN1SW(1), OPN3(2), OPRD1(2), OPRK1(3), OR10A5(1), OR11A1(3), OR12D3(1), OR1F1(1), OR1Q1(4), OR2H1(1), OR5V1(4), OR7C1(2), OR8B8(5), OXTR(4), P2RY1(4), P2RY10(3), P2RY12(7), P2RY13(3), P2RY14(2), P2RY6(3), PPYR1(5), PTAFR(2), PTGDR(4), PTGER2(2), PTGER4(1), PTGFR(3), RGR(2), RHO(2), RRH(2), SSTR1(9), SSTR2(2), SSTR3(3), SSTR4(6), SUCNR1(2), TBXA2R(6), TRHR(3)	20796316	368	77	365	138	128	116	16	86	22	0	0.0657	1.000	1.000
307	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	73	ACTB(4), ACTN1(3), ACTN2(11), ACTN3(1), ACTN4(1), ACVR1B(6), ACVR1C(3), BAIAP2(3), CDC42(1), CDH1(12), CREBBP(10), CSNK2A1(4), CSNK2A2(1), CTNNA1(4), CTNNA2(11), CTNNA3(4), CTNNB1(10), CTNND1(6), EGFR(7), EP300(13), ERBB2(5), FARP2(3), FER(4), FGFR1(8), FYN(5), IGF1R(10), INSR(9), IQGAP1(5), LEF1(4), LMO7(8), MAP3K7(6), MAPK1(2), MAPK3(1), MET(4), MLLT4(14), NLK(4), PARD3(8), PTPN6(3), PTPRB(10), PTPRF(8), PTPRJ(13), PTPRM(14), PVRL1(1), PVRL2(3), PVRL3(3), PVRL4(4), RAC2(1), RAC3(1), SMAD2(4), SMAD3(2), SNAI1(2), SNAI2(4), SORBS1(5), SSX2IP(3), TCF7(2), TCF7L1(3), TCF7L2(4), TGFBR1(2), TGFBR2(6), TJP1(6), VCL(2), WASF1(3), WASF2(2), WASF3(1), WASL(1), YES1(2)	20468843	330	77	325	112	95	110	12	62	51	0	0.0974	1.000	1.000
308	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY1(10), ADCY2(7), ADCY3(1), ADCY4(3), ADCY5(7), ADCY6(5), ADCY7(10), ADCY8(10), ADCY9(5), ADRB1(3), DRD1(2), DRD2(5), EGF(4), EGFR(7), GJA1(8), GJD2(3), GNA11(4), GNAI1(1), GNAI2(3), GNAI3(4), GNAQ(1), GNAS(11), GRB2(1), GRM1(17), GRM5(12), GUCY1A2(3), GUCY1A3(9), GUCY1B3(5), GUCY2C(6), GUCY2D(8), GUCY2F(7), HTR2A(1), HTR2B(4), HTR2C(3), ITPR1(17), ITPR2(14), ITPR3(16), MAP2K1(2), MAP2K2(1), MAP3K2(1), MAPK1(2), MAPK3(1), MAPK7(6), NPR1(6), NPR2(3), NRAS(1), PDGFA(1), PDGFB(3), PDGFC(3), PDGFD(2), PDGFRA(3), PDGFRB(7), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKG1(6), PRKG2(6), PRKX(2), RAF1(5), SOS1(3), SOS2(3), TJP1(6), TUBA1B(1), TUBA1C(2), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA8(3), TUBAL3(3), TUBB1(2), TUBB2A(2), TUBB2C(2), TUBB3(7), TUBB4(1), TUBB4Q(2), TUBB6(5), TUBB8(2)	22836567	388	73	386	144	132	117	20	92	27	0	0.258	1.000	1.000
309	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(2), ATM(13), BUB1(5), BUB1B(3), BUB3(2), CCNA1(4), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(6), CCND3(2), CCNE1(3), CCNE2(1), CCNH(1), CDAN1(5), CDC14A(6), CDC20(2), CDC25A(2), CDC25B(2), CDC25C(2), CDC6(2), CDC7(3), CDH1(12), CDK2(2), CDKN1A(1), CDKN2A(3), CHEK1(1), CHEK2(5), DTX4(3), E2F2(2), E2F3(1), E2F5(1), EP300(13), ESPL1(12), GSK3B(2), HDAC1(2), HDAC2(2), HDAC3(3), HDAC4(7), HDAC5(4), HDAC6(1), HDAC8(3), MAD1L1(5), MCM2(8), MCM3(1), MCM4(6), MCM5(6), MCM7(4), MDM2(3), MPEG1(4), ORC1L(6), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PLK1(3), PRKDC(19), PTPRA(4), RB1(7), RBL1(3), SKP2(3), TBC1D8(6), TFDP1(2), TGFB1(3)	18829699	256	71	254	100	76	75	15	56	33	1	0.642	1.000	1.000
310	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	90	ADCY1(10), ADCY2(7), ADCY3(1), ADCY4(3), ADCY5(7), ADCY6(5), ADCY7(10), ADCY8(10), ADCY9(5), AKAP1(1), AKAP10(2), AKAP11(4), AKAP12(5), AKAP3(5), AKAP4(7), AKAP6(10), AKAP7(5), AKAP8(6), AKAP9(15), ARHGEF1(2), CALM1(1), CALM2(2), CALM3(1), CHMP1B(1), GNA11(4), GNA12(1), GNA14(2), GNA15(2), GNAI2(3), GNAI3(4), GNAO1(1), GNAQ(1), GNAZ(6), GNB2(3), GNG12(1), GNG7(2), GNGT1(3), GNGT2(1), ITPR1(17), KCNJ3(5), NRAS(1), PDE1A(3), PDE1B(2), PDE1C(2), PDE4A(3), PDE4B(2), PDE4C(1), PDE7A(5), PDE7B(2), PDE8A(6), PDE8B(2), PLCB3(6), PPP3CA(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(5), PRKCG(4), PRKCH(5), PRKCI(5), PRKCQ(2), PRKD1(4), PRKD3(1), RRAS(1), SLC9A1(6), USP5(3)	20130624	272	70	267	99	91	85	10	54	32	0	0.189	1.000	1.000
311	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	107	ABL1(2), ANAPC1(13), ANAPC11(1), ANAPC2(2), ANAPC5(2), ANAPC7(1), ATM(13), ATR(5), BUB1(5), BUB1B(3), BUB3(2), CCNA1(4), CCNA2(1), CCNB1(1), CCNB2(1), CCNB3(6), CCND1(1), CCND3(2), CCNE1(3), CCNE2(1), CCNH(1), CDC14A(6), CDC16(1), CDC20(2), CDC23(4), CDC25A(2), CDC25B(2), CDC25C(2), CDC26(1), CDC27(2), CDC6(2), CDC7(3), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(3), CDKN2D(1), CHEK1(1), CHEK2(5), CREBBP(10), CUL1(8), DBF4(4), E2F2(2), E2F3(1), EP300(13), ESPL1(12), FZR1(3), GSK3B(2), HDAC1(2), HDAC2(2), MAD1L1(5), MCM2(8), MCM3(1), MCM4(6), MCM5(6), MCM7(4), MDM2(3), ORC1L(6), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), PKMYT1(3), PLK1(3), PRKDC(19), RB1(7), RBL1(3), SKP2(3), SMAD2(4), SMAD3(2), SMC1A(4), SMC1B(3), TFDP1(2), TGFB1(3), TGFB2(6), TGFB3(3), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1)	23348013	295	70	287	127	84	95	14	60	41	1	0.923	1.000	1.000
312	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(3), ADCY1(10), ADCY2(7), ADCY3(1), ADCY4(3), ADCY5(7), ADCY6(5), ADCY7(10), ADCY8(10), ADK(1), ADSL(2), ADSS(3), AK5(2), ALLC(3), AMPD1(3), AMPD2(5), AMPD3(7), APRT(2), ATIC(4), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5G3(1), ATP5J(1), ATP5J2(1), CANT1(3), DCK(1), DGUOK(1), ENPP1(1), ENPP3(2), ENTPD1(3), GART(6), GDA(1), GMPS(2), GUCY1A2(3), GUCY1A3(9), GUCY1B3(5), GUCY2C(6), GUCY2D(8), GUCY2F(7), GUK1(2), IMPDH1(1), IMPDH2(1), NPR1(6), NPR2(3), NT5C(1), NUDT2(2), PAPSS1(3), PAPSS2(2), PDE1A(3), PDE4A(3), PDE4B(2), PDE4C(1), PDE5A(3), PDE6B(5), PDE6C(2), PDE6G(1), PDE7B(2), PDE8A(6), PDE9A(2), PFAS(1), PKLR(4), PKM2(2), POLD1(7), POLE(12), POLG(3), POLL(1), POLQ(13), POLR2A(8), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(9), PPAT(1), PRPS1(1), PRPS1L1(1), PRPS2(1), PRUNE(3), RRM1(3), RRM2(2)	22198336	285	70	284	115	87	104	11	63	20	0	0.544	1.000	1.000
313	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	ARAF(5), BRAF(5), CACNA1A(9), CRHR1(2), GNA11(4), GNA12(1), GNAI1(1), GNAI2(3), GNAI3(4), GNAO1(1), GNAQ(1), GNAS(11), GNAZ(6), GRIA1(9), GRIA2(13), GRIA3(5), GRID2(10), GRM1(17), GRM5(12), GUCY1A2(3), GUCY1A3(9), GUCY1B3(5), GUCY2C(6), GUCY2D(8), GUCY2F(7), IGF1(2), IGF1R(10), ITPR1(17), ITPR2(14), ITPR3(16), LYN(2), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK3(1), NOS1(15), NOS3(3), NPR1(6), NPR2(3), NRAS(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PPP2CA(3), PPP2CB(2), PPP2R1A(4), PPP2R1B(4), PPP2R2A(2), PPP2R2B(3), PPP2R2C(3), PRKCG(4), PRKG1(6), PRKG2(6), RAF1(5), RYR1(27)	19018774	364	69	362	108	131	104	17	86	26	0	0.00907	1.000	1.000
314	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CALM1(1), CALM2(2), CALM3(1), CDS1(3), CDS2(1), DGKA(3), DGKB(4), DGKE(3), DGKH(5), DGKI(5), DGKQ(1), DGKZ(1), FN3K(2), IMPA1(3), INPP4A(1), INPP4B(3), INPP5A(3), INPP5B(2), INPP5D(1), INPP5E(2), INPPL1(12), ITGB1BP3(2), ITPK1(1), ITPKA(1), ITPKB(5), ITPR1(17), ITPR2(14), ITPR3(16), OCRL(4), PI4KA(9), PI4KB(3), PIK3C2A(4), PIK3C2B(10), PIK3C2G(3), PIK3C3(6), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PIP4K2A(3), PIP4K2B(1), PIP4K2C(1), PIP5K1A(2), PIP5K1C(5), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PLCD1(1), PLCD3(6), PLCE1(8), PLCG1(10), PLCG2(6), PLCZ1(2), PRKCG(4), PTEN(8), SYNJ1(3), SYNJ2(9)	21269212	283	68	278	93	99	88	7	54	34	1	0.0595	1.000	1.000
315	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	94	ADCY1(10), ADCY2(7), ADCY3(1), ADCY4(3), ADCY5(7), ADCY6(5), ADCY7(10), ADCY8(10), ADCY9(5), ATF4(1), CACNA1C(18), CACNA1D(12), CACNA1F(1), CACNA1S(10), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2G(4), CDC42(1), EGFR(7), ELK1(2), FSHB(1), GNA11(4), GNAQ(1), GNAS(11), GNRH2(1), GNRHR(3), GRB2(1), ITPR1(17), ITPR2(14), ITPR3(16), JUN(2), MAP2K1(2), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(1), MAP2K7(12), MAP3K1(6), MAP3K2(1), MAP3K3(2), MAP3K4(8), MAPK1(2), MAPK10(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(6), MAPK8(3), MAPK9(3), MMP14(1), MMP2(4), NRAS(1), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PLD1(7), PLD2(10), PRKACA(1), PRKACB(2), PRKACG(3), PRKCD(3), PRKX(2), PTK2B(5), RAF1(5), SOS1(3), SOS2(3)	22020073	340	68	339	117	117	109	12	64	38	0	0.0649	1.000	1.000
316	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	150	AKT1(2), AKT2(2), AKT3(3), CBL(1), CBLB(2), CBLC(1), CCND1(1), CCND3(2), CISH(1), CLCF1(1), CNTF(2), CNTFR(1), CREBBP(10), CSF2RA(5), CSF2RB(4), CSF3(1), CSF3R(5), EP300(13), EPOR(2), GH1(1), GH2(2), GHR(3), GRB2(1), IFNA1(1), IFNA10(1), IFNA16(1), IFNA17(3), IFNA5(2), IFNA7(2), IFNA8(1), IFNAR1(4), IFNAR2(4), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), IFNK(1), IFNW1(1), IL10(1), IL10RB(1), IL11(2), IL11RA(2), IL12B(1), IL12RB1(4), IL12RB2(4), IL13(1), IL13RA1(2), IL13RA2(5), IL15RA(1), IL20(1), IL20RA(3), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(3), IL26(1), IL28A(2), IL28B(3), IL2RA(1), IL2RG(3), IL3(1), IL3RA(4), IL4R(1), IL5RA(1), IL6ST(2), IL7R(3), IRF9(2), JAK1(2), JAK2(8), JAK3(3), LEPR(6), LIF(1), LIFR(5), OSM(1), OSMR(2), PIAS1(3), PIAS2(3), PIAS3(1), PIAS4(4), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PIM1(1), PRL(1), PRLR(1), PTPN11(4), PTPN6(3), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(3), SOCS7(1), SOS1(3), SOS2(3), SPRED1(3), SPRED2(5), SPRY1(2), SPRY3(3), SPRY4(3), STAM(4), STAM2(3), STAT1(4), STAT2(3), STAT3(6), STAT4(3), STAT5A(1), STAT5B(2), TPO(13), TSLP(2), TYK2(4)	24773134	317	67	313	119	97	100	16	71	32	1	0.380	1.000	1.000
317	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(12), BDKRB1(1), BDKRB2(2), C1QA(1), C1QC(3), C1R(2), C1S(3), C2(2), C3(14), C3AR1(2), C5(8), C5AR1(1), C6(6), C7(2), C8A(6), C8B(7), C9(3), CD46(1), CD55(1), CFB(2), CFH(8), CFI(3), CPB2(3), CR1(16), CR2(4), F10(3), F11(3), F12(2), F13A1(7), F13B(8), F2(3), F2R(1), F5(8), F7(6), F8(11), F9(4), FGA(4), FGB(2), KLKB1(4), KNG1(4), MASP1(1), MASP2(2), MBL2(1), PLAT(2), PLAU(2), PLG(8), PROC(3), PROS1(5), SERPINA1(3), SERPINA5(1), SERPINC1(2), SERPIND1(2), SERPINE1(2), SERPINF2(4), SERPING1(2), TFPI(3), THBD(1), VWF(9)	15733189	236	66	233	63	67	67	7	69	25	1	0.0104	1.000	1.000
318	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(3), ACTN2(11), ACTN3(1), ACTN4(1), ARHGAP5(5), BCAR1(4), CDC42(1), CDH5(4), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(3), CLDN17(2), CLDN18(1), CLDN19(2), CLDN20(3), CLDN23(3), CLDN4(4), CLDN6(1), CLDN9(3), CTNNA1(4), CTNNA2(11), CTNNA3(4), CTNNB1(10), CTNND1(6), CYBA(1), CYBB(3), ESAM(6), GNAI1(1), GNAI2(3), GNAI3(4), GRLF1(7), ICAM1(2), ITGA4(5), ITGAL(5), ITGAM(4), ITGB1(4), ITGB2(5), ITK(4), JAM3(2), MAPK13(1), MAPK14(1), MLLT4(14), MMP2(4), MMP9(6), MSN(3), MYL2(1), MYL7(1), NCF1(1), NCF2(1), NOX1(4), NOX3(3), OCLN(1), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PLCG1(10), PLCG2(6), PRKCG(4), PTK2(7), PTK2B(5), PTPN11(4), PXN(1), RAC2(1), RAP1A(2), RAP1B(3), RAPGEF3(1), RAPGEF4(3), RHOH(1), ROCK1(7), ROCK2(2), TXK(1), VASP(2), VAV1(6), VAV2(8), VAV3(6), VCAM1(5), VCL(2)	21064440	314	66	308	134	112	99	11	56	35	1	0.726	1.000	1.000
319	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(2), CD14(1), CD19(1), CD1A(1), CD1B(4), CD1C(2), CD1D(4), CD1E(5), CD2(2), CD22(1), CD33(2), CD34(2), CD36(2), CD37(1), CD38(1), CD3E(2), CD3G(2), CD4(2), CD44(5), CD5(4), CD55(1), CD7(3), CD8A(2), CD8B(1), CR1(16), CR2(4), CSF1R(6), CSF2RA(5), CSF3(1), CSF3R(5), EPOR(2), FCER2(2), FLT3(6), GP5(2), GYPA(1), HLA-DRA(3), HLA-DRB1(1), IL11(2), IL11RA(2), IL1B(1), IL1R1(3), IL1R2(1), IL2RA(1), IL3(1), IL3RA(4), IL4R(1), IL5RA(1), IL7R(3), ITGA1(3), ITGA2(4), ITGA2B(5), ITGA3(6), ITGA4(5), ITGA5(5), ITGA6(2), ITGAM(4), ITGB3(3), KIT(6), KITLG(3), MME(4), THPO(2), TNF(1), TPO(13)	14134980	193	65	189	79	56	56	8	48	25	0	0.679	1.000	1.000
320	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), AKT3(3), BCAR1(4), CAPN1(2), CAPN11(3), CAPN2(2), CAPN3(5), CAPN5(2), CAPN6(6), CAPN7(4), CAPN9(2), CAPNS1(1), CAV1(2), CDC42(1), CRK(1), CSK(2), DOCK1(10), FYN(5), GIT2(1), GRB2(1), ILK(1), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(5), ITGA3(6), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(4), ITGA8(2), ITGA9(7), ITGAD(4), ITGAE(2), ITGAL(5), ITGAM(4), ITGAV(3), ITGAX(5), ITGB1(4), ITGB2(5), ITGB3(3), ITGB4(9), ITGB5(2), ITGB6(1), ITGB7(2), ITGB8(7), MAP2K1(2), MAP2K2(1), MAP2K3(1), MAP2K6(1), MAPK10(1), MAPK4(4), MAPK6(1), MAPK7(6), MYLK2(2), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PDPK1(1), PIK3R2(4), PTK2(7), PXN(1), RAC2(1), RAC3(1), RAP1B(3), RAPGEF1(5), RHO(2), ROCK1(7), ROCK2(2), SHC1(3), SHC3(4), SORBS1(5), SOS1(3), TLN1(11), TNS1(15), VASP(2), VAV2(8), VAV3(6), VCL(2), ZYX(2)	23272910	296	65	294	132	106	83	11	61	34	1	0.895	1.000	1.000
321	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(4), ACVR1B(6), ACVRL1(2), AKT1(2), AURKB(2), BMPR1A(1), BMPR2(10), BUB1(5), CDKL1(2), CDKL2(2), CDS1(3), CDS2(1), CLK1(3), CLK2(5), CLK4(2), COL4A3BP(1), CSNK2A1(4), CSNK2A2(1), DGKA(3), DGKB(4), DGKE(3), DGKH(5), DGKQ(1), DGKZ(1), IMPA1(3), INPP4A(1), INPP4B(3), INPP5A(3), INPPL1(12), ITPKA(1), ITPKB(5), MAP3K10(6), MOS(3), NEK1(3), NEK3(1), OCRL(4), PAK4(4), PIK3C2A(4), PIK3C2B(10), PIK3C2G(3), PIK3CB(5), PIK3CG(9), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PLCD1(1), PLCG1(10), PLCG2(6), PLK3(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PRKCD(3), PRKCE(5), PRKCG(4), PRKCH(5), PRKCQ(2), PRKD1(4), PRKG1(6), RAF1(5), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KA4(2), RPS6KB1(2), TGFBR1(2), VRK1(1)	19234770	266	65	260	88	82	81	7	58	35	3	0.220	1.000	1.000
322	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(2), ALG1(3), ALG10(5), ALG10B(1), ALG12(1), ALG13(2), ALG3(1), ALG8(1), ALG9(2), B3GNT1(1), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT4(3), B4GALT5(3), B4GALT7(1), C1GALT1C1(3), CHPF(2), CHST1(8), CHST11(1), CHST12(4), CHST13(1), CHST2(7), CHST6(3), CHST7(1), CHSY1(3), EXT1(9), EXT2(3), EXTL1(3), EXTL2(2), EXTL3(5), FUT11(2), FUT8(2), GALNT10(3), GALNT11(4), GALNT12(1), GALNT13(2), GALNT14(4), GALNT2(2), GALNT4(1), GALNT5(4), GALNT6(2), GALNT8(3), GALNT9(2), GALNTL1(2), GALNTL2(4), GALNTL4(5), GALNTL5(2), GANAB(3), GCNT3(1), GCNT4(1), HS3ST1(1), HS3ST2(6), HS3ST3A1(1), HS3ST3B1(2), HS3ST5(4), HS6ST1(1), HS6ST2(1), HS6ST3(4), MAN1A2(1), MAN1B1(2), MAN1C1(3), MAN2A1(2), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(1), MGAT5(5), MGAT5B(1), NDST1(7), NDST2(5), NDST3(4), NDST4(9), OGT(1), RPN1(1), RPN2(3), ST3GAL1(2), ST3GAL2(4), ST3GAL4(3), ST6GALNAC1(1), STT3B(3), UST(5), XYLT1(7), XYLT2(4)	18849889	247	64	245	113	92	75	8	52	20	0	0.922	1.000	1.000
323	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(10), ADCY8(10), ARAF(5), ATF4(1), BRAF(5), CACNA1C(18), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2G(4), CAMK4(4), CREBBP(10), EP300(13), GNAQ(1), GRIA1(9), GRIA2(13), GRIN1(2), GRIN2A(6), GRIN2B(8), GRIN2C(3), GRM1(17), GRM5(12), ITPR1(17), ITPR2(14), ITPR3(16), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK3(1), NRAS(1), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PPP1CA(1), PPP1CC(2), PPP1R12A(1), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), RAF1(5), RAP1A(2), RAP1B(3), RAPGEF3(1), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KA6(7)	17220927	287	64	286	97	89	100	11	49	38	0	0.0738	1.000	1.000
324	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	77	ABL1(2), ACTN1(3), ACTR2(2), AKT1(2), AKT2(2), AKT3(3), ANGPTL2(4), ARHGEF6(9), ARHGEF7(8), BCAR1(4), BRAF(5), CAV1(2), CDC42(1), CDKN2A(3), CRK(1), DOCK1(10), EPHB2(6), FYN(5), GRB2(1), GRB7(6), GRLF1(7), ILK(1), ITGA1(3), ITGA10(4), ITGA11(6), ITGA2(4), ITGA3(6), ITGA4(5), ITGA5(5), ITGA6(2), ITGA7(4), ITGA8(2), ITGA9(7), ITGB3BP(1), MAP2K4(5), MAP2K7(12), MAP3K11(2), MAPK1(2), MAPK10(1), MAPK8(3), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(7), MAPK9(3), MYLK(7), MYLK2(2), P4HB(2), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PIK3CB(5), PKLR(4), PLCG1(10), PLCG2(6), PTEN(8), PTK2(7), RAF1(5), RHO(2), ROCK1(7), ROCK2(2), SHC1(3), SOS1(3), SOS2(3), TERF2IP(3), TLN1(11), TLN2(18), VASP(2), ZYX(2)	20847078	303	64	302	103	105	87	10	63	38	0	0.127	1.000	1.000
325	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(16), ASH2L(3), C17orf79(1), CARM1(2), CTCFL(4), DOT1L(7), EED(1), EHMT1(6), EHMT2(3), EZH1(1), EZH2(3), FBXO11(6), HCFC1(9), HSF4(2), JMJD4(1), JMJD6(1), KDM6A(5), MEN1(3), MLL(13), MLL2(28), MLL3(30), MLL4(16), MLL5(10), NSD1(10), OGT(1), PAXIP1(5), PPP1CA(1), PPP1CC(2), PRDM2(14), PRDM9(8), PRMT1(1), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(3), RBBP5(1), SATB1(7), SETD1A(6), SETD2(4), SETDB1(8), SETDB2(3), SMYD3(2), STK38(1), SUV39H1(4), SUV39H2(1), SUV420H1(4), SUV420H2(1), SUZ12(1), WHSC1(7), WHSC1L1(6)	20585669	277	63	274	93	82	80	6	55	48	6	0.335	1.000	1.000
326	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(14), ACACB(10), AKT1(2), AKT2(2), AKT3(3), ARAF(5), BAD(1), BRAF(5), CALM1(1), CALM2(2), CALM3(1), CBL(1), CBLB(2), CBLC(1), CRK(1), EIF4EBP1(1), ELK1(2), EXOC7(6), FASN(9), FBP1(1), FBP2(3), FLOT1(1), FLOT2(3), GCK(3), GRB2(1), GSK3B(2), GYS1(4), GYS2(2), IKBKB(3), INPP5D(1), INSR(9), IRS1(6), IRS2(3), IRS4(9), LIPE(4), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(3), MAPK9(3), MKNK1(1), NRAS(1), PCK1(2), PCK2(5), PDE3A(6), PDE3B(8), PDPK1(1), PFKL(4), PFKM(2), PFKP(7), PHKA1(5), PHKA2(7), PHKG1(2), PHKG2(2), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PKLR(4), PKM2(2), PPARGC1A(4), PPP1CA(1), PPP1CC(2), PPP1R3A(11), PPP1R3B(4), PPP1R3C(3), PPP1R3D(2), PRKAA1(1), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAG3(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PRKCI(5), PRKX(2), PTPRF(8), PYGB(4), PYGL(3), PYGM(5), RAF1(5), RAPGEF1(5), RHEB(1), RPS6(1), RPS6KB1(2), RPS6KB2(2), SH2B2(2), SHC1(3), SHC2(2), SHC3(4), SLC2A4(1), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(3), SORBS1(5), SOS1(3), SOS2(3), SREBF1(2), TRIP10(4), TSC1(3), TSC2(3)	27214881	370	63	368	159	135	115	11	66	42	1	0.720	1.000	1.000
327	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	97	ADCY1(10), ADCY2(7), ADCY3(1), ADCY4(3), ADCY5(7), ADCY6(5), ADCY7(10), ADCY8(10), ADCY9(5), ASIP(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2G(4), CREB1(4), CREB3(2), CREB3L1(2), CREB3L2(1), CREB3L3(3), CREBBP(10), CTNNB1(10), DCT(6), DVL1(2), DVL2(2), DVL3(4), EDN1(3), EP300(13), FZD1(5), FZD10(7), FZD2(2), FZD3(4), FZD4(2), FZD5(1), FZD6(5), FZD7(1), FZD8(2), GNAI1(1), GNAI2(3), GNAI3(4), GNAO1(1), GNAQ(1), GNAS(11), GSK3B(2), KIT(6), KITLG(3), LEF1(4), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MITF(6), NRAS(1), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), POMC(5), PRKACA(1), PRKACB(2), PRKACG(3), PRKCG(4), PRKX(2), RAF1(5), TCF7(2), TCF7L1(3), TCF7L2(4), TYR(3), TYRP1(5), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(4), WNT3A(1), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(1), WNT9A(1), WNT9B(2)	18540068	311	63	308	124	113	92	11	58	36	1	0.339	1.000	1.000
328	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(4), BAD(1), BCL2(1), CABIN1(5), CALM1(1), CALM2(2), CALM3(1), CAMK4(4), CD3E(2), CD3G(2), CDKN1A(1), CNR1(5), CREBBP(10), CSNK2A1(4), CTLA4(3), EGR2(3), EGR3(1), EP300(13), FCGR3A(1), GATA3(3), GATA4(3), GRLF1(7), GSK3A(1), GSK3B(2), ICOS(1), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL13(1), IL1B(1), IL2RA(1), IL3(1), IL8(1), ITK(4), KPNA5(5), MAP2K7(12), MAPK14(1), MAPK8(3), MAPK9(3), MEF2B(3), MEF2D(5), MYF5(2), NCK2(2), NFAT5(4), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NFKB2(3), NFKBIB(4), NPPB(1), NUP214(12), OPRD1(2), PAK1(4), PIN1(1), PPP3CB(1), PTPRC(14), RELA(1), RPL13A(1), SLA(1), SP1(3), SP3(3), TGFB1(3), TNF(1), TRAF2(2), TRPV6(3), VAV1(6), VAV2(8), VAV3(6), XPO5(1)	15737448	243	62	241	93	71	82	8	53	29	0	0.439	1.000	1.000
329	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(7), AMY2A(2), AMY2B(3), ASCC3(16), ATP13A2(5), DDX18(7), DDX19A(2), DDX23(5), DDX4(2), DDX41(6), DDX47(1), DDX50(2), DDX51(2), DDX54(6), DDX55(3), DDX56(4), DHX58(4), ENPP1(1), ENPP3(2), ENTPD7(8), EP400(17), ERCC2(4), ERCC3(3), GAA(2), GANC(4), GBA(4), GBA3(1), GBE1(2), GCK(3), GPI(4), GUSB(2), GYS1(4), GYS2(2), HK1(5), HK2(5), HK3(3), IFIH1(2), LYZL1(2), MGAM(6), MOV10L1(3), NUDT8(1), PGM1(2), PGM3(6), PYGB(4), PYGL(3), PYGM(5), RAD54B(3), RAD54L(2), RUVBL2(2), SETX(8), SI(10), SKIV2L2(3), SMARCA2(12), SMARCA5(1), TREH(2), UGDH(4), UGP2(1), UGT1A1(1), UGT1A5(3), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), UXS1(3)	21297805	259	62	259	88	86	87	9	44	33	0	0.160	1.000	1.000
330	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(2), AKT2(2), AKT3(3), BAD(1), CDC42(1), CDK2(2), CDKN2A(3), CREB1(4), CREB3(2), CREB5(1), EBP(1), ERBB4(16), F2RL2(1), GAB1(1), GRB2(1), GSK3A(1), GSK3B(2), IGF1(2), IGFBP1(2), INPPL1(12), IRS1(6), IRS2(3), IRS4(9), MET(4), NOLC1(6), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PARD3(8), PDK1(1), PIK3CD(8), PPP1R13B(5), PREX1(8), PTEN(8), PTK2(7), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KB1(2), SHC1(3), SLC2A4(1), SOS1(3), SOS2(3), TSC1(3), TSC2(3), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1)	12982966	186	62	184	67	64	59	10	25	28	0	0.230	1.000	1.000
331	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	AKT1(2), AKT2(2), AKT3(3), CARD11(9), CBL(1), CBLB(2), CBLC(1), CD247(2), CD3E(2), CD3G(2), CD4(2), CD40LG(4), CD8A(2), CD8B(1), CDC42(1), CTLA4(3), FYN(5), GRAP2(1), GRB2(1), ICOS(1), IFNG(2), IKBKB(3), IL10(1), ITK(4), JUN(2), LCP2(5), MALT1(4), MAP3K14(2), NCK1(3), NCK2(2), NFAT5(4), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NFKB1(5), NFKB2(3), NFKBIB(4), NRAS(1), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PDCD1(1), PDK1(1), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PLCG1(10), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKCQ(2), PTPN6(3), PTPRC(14), RASGRP1(4), SOS1(3), SOS2(3), TEC(3), TNF(1), VAV1(6), VAV2(8), VAV3(6), ZAP70(2)	17041774	243	61	239	95	70	76	7	62	28	0	0.611	1.000	1.000
332	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	122	ARAF(5), BID(1), BRAF(5), CASP3(1), CD244(1), CD247(2), FAS(2), FCGR3A(1), FCGR3B(2), FYN(5), GRB2(1), HLA-A(6), HLA-C(3), HLA-E(2), HLA-G(2), ICAM1(2), ICAM2(2), IFNA1(1), IFNA10(1), IFNA16(1), IFNA17(3), IFNA5(2), IFNA7(2), IFNA8(1), IFNAR1(4), IFNAR2(4), IFNB1(2), IFNG(2), IFNGR1(2), IFNGR2(1), ITGAL(5), ITGB2(5), KIR2DL1(3), KIR2DL3(1), KIR2DL4(1), KIR3DL1(2), KLRC1(2), KLRC2(2), KLRD1(2), LCP2(5), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MICB(1), NCR1(1), NCR2(3), NFAT5(4), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NRAS(1), PAK1(4), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PLCG1(10), PLCG2(6), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRF1(1), PRKCG(4), PTK2B(5), PTPN11(4), PTPN6(3), RAC2(1), RAC3(1), RAF1(5), SH2D1A(1), SH3BP2(2), SHC1(3), SHC2(2), SHC3(4), SOS1(3), SOS2(3), SYK(3), TNF(1), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(2), ULBP1(2), ULBP3(1), VAV1(6), VAV2(8), VAV3(6), ZAP70(2)	18949847	278	60	275	101	81	94	9	57	37	0	0.213	1.000	1.000
333	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	85	ACVR1(4), ACVR1B(6), ACVR1C(3), ACVR2B(2), ACVRL1(2), AMHR2(2), BMP2(2), BMP4(4), BMP5(6), BMP6(5), BMP7(2), BMP8B(1), BMPR1A(1), BMPR1B(2), BMPR2(10), CHRD(1), COMP(1), CREBBP(10), CUL1(8), DCN(2), E2F5(1), EP300(13), FST(1), GDF5(4), GDF6(6), GDF7(1), IFNG(2), INHBA(5), INHBB(6), INHBC(1), INHBE(1), LEFTY2(1), LTBP1(9), MAPK1(2), MAPK3(1), PITX2(2), PPP2CA(3), PPP2CB(2), PPP2R1A(4), PPP2R1B(4), PPP2R2A(2), PPP2R2B(3), PPP2R2C(3), RBL1(3), ROCK1(7), ROCK2(2), RPS6KB1(2), RPS6KB2(2), SMAD1(1), SMAD2(4), SMAD3(2), SMAD5(1), SMAD6(3), SMAD7(2), SMAD9(4), SMURF1(1), SMURF2(1), SP1(3), TFDP1(2), TGFB1(3), TGFB2(6), TGFB3(3), TGFBR1(2), TGFBR2(6), THBS1(7), THBS2(6), THBS3(4), THBS4(3), TNF(1), ZFYVE16(6), ZFYVE9(1)	16638882	239	59	236	99	86	66	14	39	32	2	0.636	1.000	1.000
334	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	83	ABL1(2), ABL2(3), AKT1(2), AKT2(2), AKT3(3), ARAF(5), BAD(1), BRAF(5), BTC(1), CAMK2A(1), CAMK2G(4), CBL(1), CBLB(2), CBLC(1), CDKN1A(1), CRK(1), EGF(4), EGFR(7), EIF4EBP1(1), ELK1(2), ERBB2(5), ERBB3(16), ERBB4(16), EREG(2), GAB1(1), GRB2(1), GSK3B(2), JUN(2), MAP2K1(2), MAP2K2(1), MAP2K4(5), MAP2K7(12), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(3), MAPK9(3), NCK1(3), NCK2(2), NRAS(1), NRG1(5), NRG2(4), NRG3(9), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PLCG1(10), PLCG2(6), PRKCG(4), PTK2(7), RAF1(5), RPS6KB1(2), RPS6KB2(2), SHC1(3), SHC2(2), SHC3(4), SOS1(3), SOS2(3), STAT5A(1), STAT5B(2), TGFA(2)	17333506	257	58	250	100	81	80	10	53	33	0	0.495	1.000	1.000
335	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(2), CCKBR(4), CCR2(2), CCR3(4), CCR5(1), CELSR1(12), CELSR2(15), CELSR3(12), CHRM2(6), CHRM3(5), CIDEB(1), DRD4(1), EDNRA(1), EMR2(1), EMR3(3), F2R(1), FSHR(12), GNRHR(3), GPR116(11), GPR132(1), GPR133(7), GPR135(6), GPR143(1), GPR17(1), GPR55(5), GPR56(1), GPR61(3), GPR84(1), GRM1(17), GRPR(2), HRH4(1), LGR6(4), LPHN2(9), LPHN3(10), LTB4R2(2), NTSR1(4), OR2M4(1), OR8G2(3), P2RY13(3), PTGFR(3), SMO(6), SSTR2(2), TAAR5(2), TSHR(6), VN1R1(3)	11443507	201	57	199	60	60	63	10	56	12	0	0.0215	1.000	1.000
336	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(3), ABCA10(9), ABCA12(18), ABCA13(24), ABCA2(3), ABCA3(7), ABCA4(6), ABCA5(4), ABCA6(3), ABCA7(3), ABCA8(6), ABCA9(7), ABCB1(8), ABCB10(7), ABCB11(4), ABCB4(9), ABCB5(5), ABCB6(3), ABCB7(1), ABCB8(4), ABCB9(2), ABCC1(3), ABCC10(3), ABCC11(10), ABCC12(7), ABCC2(8), ABCC3(6), ABCC4(6), ABCC5(4), ABCC6(5), ABCC8(7), ABCC9(17), ABCD1(2), ABCD2(2), ABCD3(3), ABCD4(4), ABCG1(2), ABCG2(2), ABCG4(3), ABCG5(1), ABCG8(3), CFTR(2), TAP1(3), TAP2(6)	20540815	245	57	244	99	73	82	10	54	26	0	0.479	1.000	1.000
337	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	97	AKT1(2), AKT2(2), AKT3(3), CASP8(5), CCL5(1), CD14(1), CD40(1), CD80(1), CD86(1), CXCL9(1), IFNA1(1), IFNA10(1), IFNA16(1), IFNA17(3), IFNA5(2), IFNA7(2), IFNA8(1), IFNAR1(4), IFNAR2(4), IFNB1(2), IKBKB(3), IKBKE(5), IL12B(1), IL1B(1), IL8(1), IRAK1(4), IRAK4(2), IRF5(2), IRF7(1), JUN(2), MAP2K1(2), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(1), MAP2K7(12), MAP3K7(6), MAPK1(2), MAPK10(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK9(3), MYD88(1), NFKB1(5), NFKB2(3), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), RELA(1), SPP1(1), STAT1(4), TBK1(2), TICAM1(5), TIRAP(2), TLR1(4), TLR2(1), TLR3(2), TLR4(11), TLR5(3), TLR6(1), TLR7(3), TLR8(6), TLR9(10), TNF(1), TOLLIP(1), TRAF3(2), TRAF6(4)	15138171	209	57	203	76	64	57	10	52	26	0	0.370	1.000	1.000
338	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(2), BDKRB2(2), CALM1(1), CALM2(2), CALM3(1), CAV1(2), CHRM1(2), CHRNA1(3), FLT1(5), FLT4(6), KDR(4), NOS3(3), PDE2A(6), PDE3A(6), PDE3B(8), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PRKG1(6), PRKG2(6), RYR2(35), SLC7A1(2)	7085873	116	56	116	47	33	38	5	34	6	0	0.486	1.000	1.000
339	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(13), CCNA1(4), CCNB1(1), CCND1(1), CCND3(2), CCNE1(3), CCNE2(1), CCNH(1), CDC25A(2), CDK2(2), CDKN1A(1), CDKN2A(3), CDKN2D(1), CREB3(2), CREB3L1(2), CREB3L3(3), E2F2(2), E2F3(1), E2F5(1), GBA2(1), MCM2(8), MCM3(1), MCM4(6), MCM5(6), MCM7(4), MDM2(3), MNAT1(2), MYT1(9), NACA(1), ORC1L(6), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(2), POLE(12), POLE2(1), PRIM1(1), RB1(7), RBL1(3), RPA1(1), RPA2(1), RPA3(1), TFDP1(2), TFDP2(2), TNXB(22)	13173952	162	55	160	72	62	46	6	33	14	1	0.781	1.000	1.000
340	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(2), ACTB(4), ARHGEF2(4), CD14(1), CDC42(1), CDH1(12), CLDN1(1), CTNNB1(10), CTTN(2), FYN(5), HCLS1(1), ITGB1(4), KRT18(2), NCK1(3), NCK2(2), NCL(6), OCLN(1), ROCK1(7), ROCK2(2), TLR4(11), TLR5(3), TUBA1B(1), TUBA1C(2), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA8(3), TUBAL3(3), TUBB1(2), TUBB2A(2), TUBB2C(2), TUBB3(7), TUBB4(1), TUBB4Q(2), TUBB6(5), TUBB8(2), WASL(1), YWHAQ(1), YWHAZ(1)	9037385	130	55	126	53	38	40	5	37	10	0	0.654	1.000	1.000
341	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(2), ACTB(4), ARHGEF2(4), CD14(1), CDC42(1), CDH1(12), CLDN1(1), CTNNB1(10), CTTN(2), FYN(5), HCLS1(1), ITGB1(4), KRT18(2), NCK1(3), NCK2(2), NCL(6), OCLN(1), ROCK1(7), ROCK2(2), TLR4(11), TLR5(3), TUBA1B(1), TUBA1C(2), TUBA3C(4), TUBA3D(3), TUBA3E(4), TUBA8(3), TUBAL3(3), TUBB1(2), TUBB2A(2), TUBB2C(2), TUBB3(7), TUBB4(1), TUBB4Q(2), TUBB6(5), TUBB8(2), WASL(1), YWHAQ(1), YWHAZ(1)	9037385	130	55	126	53	38	40	5	37	10	0	0.654	1.000	1.000
342	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(2), AK3(4), CAD(5), CANT1(3), CTPS(1), CTPS2(2), DCK(1), DCTD(1), DHODH(1), DPYD(10), DPYS(1), DUT(1), ENTPD1(3), ENTPD3(3), ENTPD4(6), ENTPD6(1), ENTPD8(4), NME6(2), NME7(1), NT5C(1), NT5C1A(1), NT5C1B(4), NT5C2(5), NUDT2(2), PNPT1(2), POLA1(4), POLA2(2), POLD1(7), POLD3(1), POLE(12), POLE2(1), POLE3(1), POLE4(1), POLR1A(5), POLR1C(2), POLR1D(1), POLR2A(8), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(10), POLR3B(3), POLR3G(1), POLR3K(1), PRIM1(1), PRIM2(3), RRM1(3), RRM2(2), RRM2B(2), TK1(1), TK2(3), TXNRD1(4), TXNRD2(2), TYMS(1), UCK1(2), UCK2(1), UMPS(1), UPB1(1), UPP2(4), UPRT(1)	14069749	167	54	167	53	57	51	7	32	20	0	0.0815	1.000	1.000
343	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	43	ACTR2(2), AKT1(2), AKT2(2), AKT3(3), ANGPTL2(4), ARHGAP4(2), ARHGEF11(10), BTK(2), CDC42(1), CFL1(1), GDI1(1), INPPL1(12), ITPR1(17), ITPR2(14), ITPR3(16), LIMK1(3), MYLK(7), MYLK2(2), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PDK1(1), PIK3CD(8), PIK3CG(9), PIK3R1(5), PITX2(2), PPP1R13B(5), PTEN(8), RACGAP1(2), RHO(2), ROCK1(7), ROCK2(2), WASF1(3), WASL(1)	11827107	174	54	172	56	64	49	10	28	23	0	0.102	1.000	1.000
344	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(19), AXIN1(7), CCND1(1), CCND3(2), CSNK1E(6), CTNNB1(10), DVL1(2), DVL2(2), DVL3(4), FBXW2(2), FZD1(5), FZD10(7), FZD2(2), FZD3(4), FZD5(1), FZD6(5), FZD7(1), FZD8(2), GSK3B(2), JUN(2), LDLR(4), MAPK10(1), MAPK9(3), PAFAH1B1(3), PLAU(2), PPP2R5C(1), PPP2R5E(4), PRKCD(3), PRKCE(5), PRKCG(4), PRKCH(5), PRKCI(5), PRKCQ(2), PRKD1(4), SFRP4(2), TCF7(2), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(4), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2)	10273823	170	54	167	72	59	33	8	39	28	3	0.668	1.000	1.000
345	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(5), ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH5(1), ADH6(2), ADH7(1), ADHFE1(6), ALDH1A3(5), ALDH3A1(3), ALDH3B2(4), AOC2(4), AOC3(3), AOX1(2), CARM1(2), COMT(3), DBH(1), DCT(6), DDC(3), ESCO2(1), FAH(1), GOT1(1), GOT2(2), GSTZ1(3), HGD(2), HPD(1), LCMT1(1), LCMT2(6), MAOA(1), MAOB(3), METTL6(1), MYST3(8), MYST4(10), NAT6(2), PNMT(3), PNPLA3(1), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(3), SH3GLB1(1), TAT(1), TH(1), TPO(13), TYR(3), TYRP1(5), WBSCR22(2)	10298224	144	53	143	39	39	40	4	42	18	1	0.0359	1.000	1.000
346	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(2), BMP4(4), BMP5(6), BMP6(5), BMP7(2), BMP8B(1), BTRC(3), CSNK1A1L(2), CSNK1E(6), CSNK1G1(1), CSNK1G2(2), CSNK1G3(4), DHH(3), FBXW11(5), GLI1(8), GLI2(6), GLI3(15), GSK3B(2), HHIP(5), IHH(2), LRP2(31), PRKACA(1), PRKACB(2), PRKACG(3), PRKX(2), PTCH1(8), PTCH2(4), SMO(6), STK36(8), SUFU(2), WNT1(3), WNT10A(3), WNT10B(1), WNT11(1), WNT16(3), WNT2(2), WNT2B(7), WNT3(4), WNT3A(1), WNT5A(3), WNT5B(2), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(1), WNT9A(1), WNT9B(2)	10422597	190	53	189	69	73	53	8	36	20	0	0.273	1.000	1.000
347	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(2), ADCY4(3), ADCY6(5), ADCY8(10), CACNA1A(9), CACNA1B(11), GNAS(11), GNAT3(2), GRM4(2), ITPR3(16), KCNB1(4), PDE1A(3), PLCB2(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKX(2), SCNN1A(2), SCNN1B(5), SCNN1G(3), TAS1R1(4), TAS1R2(3), TAS1R3(5), TAS2R1(1), TAS2R10(1), TAS2R13(2), TAS2R16(3), TAS2R3(2), TAS2R38(3), TAS2R39(3), TAS2R4(2), TAS2R40(2), TAS2R43(1), TAS2R60(3), TAS2R7(2), TAS2R8(1), TAS2R9(2), TRPM5(2)	9857252	141	53	141	61	48	45	6	34	8	0	0.680	1.000	1.000
348	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(4), AR(7), ESR1(4), ESR2(5), HNF4A(5), NR0B1(2), NR1D1(2), NR1D2(3), NR1H2(4), NR1H3(2), NR1I2(3), NR1I3(3), NR2C2(2), NR2F1(3), NR2F2(3), NR2F6(2), NR3C1(4), NR4A1(1), NR4A2(4), NR5A1(5), PGR(6), PPARA(3), PPARD(4), PPARG(1), RARA(1), RARB(5), ROR1(5), RORA(2), RORC(3), RXRA(2), RXRG(3), THRA(2), THRB(3), VDR(3)	7251766	111	53	110	44	38	20	7	34	12	0	0.626	1.000	1.000
349	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	FN3K(2), IMPA1(3), INPP4A(1), INPP4B(3), INPP5A(3), INPP5B(2), INPP5E(2), INPPL1(12), IPMK(1), ISYNA1(2), ITGB1BP3(2), ITPK1(1), ITPKA(1), ITPKB(5), MINPP1(3), OCRL(4), PI4KA(9), PI4KB(3), PIK3C3(6), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIP4K2A(3), PIP4K2B(1), PIP4K2C(1), PIP5K1A(2), PIP5K1C(5), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PLCD1(1), PLCD3(6), PLCE1(8), PLCG1(10), PLCG2(6), PLCZ1(2), PTEN(8), SYNJ1(3), SYNJ2(9)	12462707	177	52	174	51	64	60	1	32	19	1	0.0210	1.000	1.000
350	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AIFM1(1), AKT1(2), AKT2(2), AKT3(3), APAF1(2), ATM(13), BAD(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CAPN1(2), CAPN2(2), CASP10(3), CASP3(1), CASP6(1), CASP7(2), CASP8(5), CASP9(1), CSF2RB(4), DFFA(2), DFFB(2), ENDOG(1), FAS(2), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(3), IL3(1), IL3RA(4), IRAK1(4), IRAK2(4), IRAK3(2), IRAK4(2), MAP3K14(2), MYD88(1), NFKB1(5), NFKB2(3), NTRK1(3), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), RELA(1), TNF(1), TNFRSF10A(2), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(1), TNFRSF1A(2), TNFSF10(2), TRAF2(2)	13957533	168	52	164	57	54	52	5	36	20	1	0.266	1.000	1.000
351	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(2), ADAM17(3), ATP6AP1(3), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(4), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), CASP3(1), CCL5(1), CDC42(1), CSK(2), EGFR(7), GIT1(2), IGSF5(2), IKBKB(3), IL8(1), JAM3(2), JUN(2), LYN(2), MAP2K4(5), MAP3K14(2), MAPK10(1), MAPK13(1), MAPK14(1), MAPK8(3), MAPK9(3), MET(4), NFKB1(5), NFKB2(3), NOD1(6), PAK1(4), PLCG1(10), PLCG2(6), PTPN11(4), PTPRZ1(13), RELA(1), TCIRG1(4), TJP1(6)	12155383	151	52	150	62	36	47	5	46	17	0	0.738	1.000	1.000
352	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(2), CDC40(4), CLK2(5), CLK3(5), CLK4(2), COL2A1(8), CPSF1(9), CPSF2(2), CPSF3(1), CPSF4(2), CSTF1(4), CSTF2(3), CSTF2T(2), CSTF3(4), DDIT3(3), DDX1(2), DDX20(3), DHX15(8), DHX16(4), DHX38(7), DHX8(4), DHX9(1), DICER1(3), DNAJC8(1), GIPC1(2), METTL3(1), NCBP1(4), NUDT21(1), NXF1(2), PABPN1(2), PAPOLA(2), PHF5A(1), POLR2A(8), PPM1G(2), PRPF3(2), PRPF4(3), PRPF4B(9), PRPF8(9), PSKH1(4), PTBP1(4), PTBP2(1), RBM5(2), RNGTT(1), RNMT(3), SF3A1(2), SF3A2(1), SF3A3(2), SF3B1(4), SF3B2(4), SF3B4(3), SF4(3), SFRS12(3), SFRS14(6), SFRS16(2), SFRS4(2), SFRS5(3), SFRS6(4), SFRS7(2), SFRS8(7), SFRS9(1), SNRPA(4), SNRPA1(2), SNRPB(1), SNRPD1(2), SNRPD2(2), SNRPD3(1), SNRPE(1), SNRPG(1), SNRPN(3), SPOP(2), SRPK1(2), SRPK2(4), SRRM1(3), SUPT5H(6), U2AF1(1), U2AF2(2), XRN2(10)	18250315	248	52	248	77	91	70	14	50	23	0	0.149	1.000	1.000
353	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR1(1), AGTR2(1), ATP8A1(5), AVPR1A(6), AVPR1B(1), AVPR2(1), BDKRB1(1), BDKRB2(2), C3AR1(2), CCKAR(1), CCKBR(4), CCR1(2), CCR10(1), CCR2(2), CCR3(4), CCR5(1), CCR8(1), CX3CR1(3), CXCR6(1), EDNRA(1), FPR1(1), FSHR(12), GALR1(2), GALR2(1), GALR3(1), GALT(1), GHSR(3), GNRHR(3), GRPR(2), LHCGR(7), MC2R(2), MC3R(2), MC4R(4), MC5R(5), NPY1R(1), NPY2R(1), NTSR1(4), OPRD1(2), OPRK1(3), OXTR(4), PPYR1(5), SSTR1(9), SSTR2(2), SSTR3(3), SSTR4(6), TACR1(3), TACR2(1), TACR3(6), TRHR(3), TSHR(6)	8852875	146	52	145	49	51	56	3	29	7	0	0.0314	1.000	1.000
354	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	BRAF(5), CREB1(4), DAXX(3), ELK1(2), GRB2(1), IKBKB(3), JUN(2), MAP2K1(2), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(1), MAP2K7(12), MAP3K1(6), MAP3K10(6), MAP3K11(2), MAP3K12(4), MAP3K13(3), MAP3K14(2), MAP3K2(1), MAP3K3(2), MAP3K4(8), MAP3K5(3), MAP3K6(5), MAP3K7(6), MAP3K9(5), MAP4K1(2), MAP4K2(3), MAP4K3(1), MAP4K4(4), MAP4K5(3), MAPK1(2), MAPK10(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(4), MAPK6(1), MAPK7(6), MAPK8(3), MAPK9(3), MAPKAPK3(1), MAPKAPK5(2), MAX(1), MEF2B(3), MEF2C(2), MEF2D(5), MKNK1(1), NFKB1(5), PAK1(4), PAK2(5), RAF1(5), RELA(1), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KA4(2), RPS6KB1(2), RPS6KB2(2), SHC1(3), SP1(3), STAT1(4), TGFB1(3), TGFB2(6), TGFB3(3), TGFBR1(2), TRAF2(2)	16528534	211	51	209	75	76	60	6	37	32	0	0.305	1.000	1.000
355	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	AKT1(2), AKT2(2), AKT3(3), BCR(6), BTK(2), CD19(1), CDKN2A(3), FLOT1(1), FLOT2(3), GAB1(1), ITPR1(17), ITPR2(14), ITPR3(16), LYN(2), NR0B2(1), PDK1(1), PHF11(1), PITX2(2), PLCG2(6), PPP1R13B(5), PREX1(8), PTEN(8), PTPRC(14), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KB1(2), SYK(3), TEC(3), VAV1(6)	9251991	146	51	145	50	52	40	5	31	18	0	0.250	1.000	1.000
356	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	APAF1(2), BAG4(1), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP2(2), CASP3(1), CASP6(1), CASP7(2), CASP8(5), CASP9(1), DAXX(3), DFFA(2), DFFB(2), GSN(5), LMNA(5), LMNB1(1), LMNB2(2), MAP2K7(12), MAP3K1(6), MAP3K14(2), MAP3K5(3), MAPK8(3), MDM2(3), NFKB1(5), NUMA1(10), PAK2(5), PRKCD(3), PRKDC(19), PSEN1(1), PSEN2(2), PTK2(7), RASA1(9), RB1(7), RELA(1), SPTAN1(10), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF1(2), TRAF2(2)	12066271	158	50	156	51	52	48	8	26	23	1	0.123	1.000	1.000
357	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	63	APAF1(2), ATM(13), ATR(5), BAI1(5), BID(1), CASP3(1), CASP8(5), CASP9(1), CCNB1(1), CCNB2(1), CCNB3(6), CCND1(1), CCND3(2), CCNE1(3), CCNE2(1), CD82(1), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(3), CHEK1(1), CHEK2(5), DDB2(1), FAS(2), GTSE1(2), IGF1(2), IGFBP3(4), LRDD(4), MDM2(3), MDM4(3), PERP(2), PPM1D(3), PTEN(8), RFWD2(3), RPRM(3), RRM2(2), RRM2B(2), SERPINB5(1), SERPINE1(2), SESN1(1), SESN2(1), SESN3(2), SIAH1(1), STEAP3(4), THBS1(7), TNFRSF10B(2), TP73(1), TSC2(3), ZMAT3(2)	11153952	136	50	135	54	42	44	5	26	18	1	0.599	1.000	1.000
358	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	BRAF(5), CPEB1(2), EGFR(7), ERBB2(5), ERBB4(16), ETS1(4), ETS2(1), ETV6(2), ETV7(1), FMN2(9), GRB2(1), MAP2K1(2), MAPK1(2), MAPK3(1), NOTCH1(12), NOTCH2(8), NOTCH3(8), NOTCH4(6), PIWIL1(4), PIWIL2(4), PIWIL3(1), PIWIL4(2), RAF1(5), SOS1(3), SOS2(3), SPIRE1(2), SPIRE2(1)	8912689	117	50	115	54	43	33	4	27	10	0	0.836	1.000	1.000
359	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(10), ACSL1(2), ACSL3(5), ACSL4(2), ACSL5(2), ACSL6(4), ADIPOQ(2), ADIPOR1(2), ADIPOR2(2), AGRP(1), AKT1(2), AKT2(2), AKT3(3), CAMKK1(3), CD36(2), CPT1A(4), CPT1B(3), CPT1C(2), CPT2(4), IKBKB(3), IRS1(6), IRS2(3), IRS4(9), JAK1(2), JAK2(8), JAK3(3), LEPR(6), MAPK10(1), MAPK8(3), MAPK9(3), NFKB1(5), NFKB2(3), NFKBIB(4), NPY(1), PCK1(2), PCK2(5), POMC(5), PPARA(3), PPARGC1A(4), PRKAA1(1), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2), PRKAG3(2), PRKCQ(2), PTPN11(4), RELA(1), RXRA(2), RXRG(3), SLC2A1(3), SLC2A4(1), SOCS3(3), STAT3(6), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(2), TYK2(4)	14327176	182	50	182	71	65	42	6	44	24	1	0.578	1.000	1.000
360	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(2), AKT2(2), AKT3(3), BRD4(5), CAP1(1), CBL(1), CDC42(1), CDKN2A(3), F2RL2(1), FLOT1(1), FLOT2(3), GRB2(1), GSK3A(1), GSK3B(2), IGFBP1(2), INPPL1(12), IRS1(6), IRS2(3), IRS4(9), LNPEP(8), MAPK1(2), MAPK3(1), PARD3(8), PDK1(1), PIK3CD(8), PIK3R1(5), PPYR1(5), PTEN(8), RAF1(5), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KB1(2), SERPINB6(3), SHC1(3), SLC2A4(1), SORBS1(5), SOS1(3), SOS2(3), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1)	9888332	147	50	145	52	62	46	1	19	19	0	0.257	1.000	1.000
361	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(2), AKT3(3), ASAH1(2), BRAF(5), DAG1(5), DRD2(5), EGFR(7), EPHB2(6), GRB2(1), ITPKA(1), ITPKB(5), ITPR1(17), ITPR2(14), ITPR3(16), KCNJ3(5), KCNJ5(2), MAPK1(2), PI3(1), PIK3CB(5), PITX2(2), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), RAF1(5), RGS20(1), SHC1(3), SOS1(3), SOS2(3), STAT3(6), TERF2IP(3)	10170656	157	50	157	53	52	50	5	33	16	1	0.204	1.000	1.000
362	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), AKT2(2), AKT3(3), ANKRD6(1), APC(19), AXIN1(7), AXIN2(3), CER1(2), CTNNB1(10), DACT1(4), DKK1(4), DKK2(2), DKK3(1), DKK4(1), DVL1(2), GSK3A(1), GSK3B(2), LRP1(18), MVP(2), NKD1(5), NKD2(1), PIN1(1), PSEN1(1), PTPRA(4), SENP2(2), SFRP1(2), TSHB(1), WIF1(2)	6992327	105	50	103	38	34	33	2	21	13	2	0.453	1.000	1.000
363	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(4), APC(19), AXIN1(7), BMP10(2), BMP2(2), BMP4(4), BMP5(6), BMP7(2), BMPR1A(1), BMPR2(10), CHRD(1), CTNNB1(10), DVL1(2), FZD1(5), GATA4(3), GSK3B(2), MAP3K7(6), MEF2C(2), MYL2(1), NKX2-5(2), NPPA(1), NPPB(1), RFC1(1), TGFB1(3), TGFB2(6), TGFB3(3), TGFBR1(2), TGFBR2(6), TGFBR3(2), WNT1(3)	6284674	119	49	116	38	30	30	5	31	19	4	0.413	1.000	1.000
364	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(3), ALPL(3), ALPP(4), ALPPL2(4), ASCC3(16), ATP13A2(5), DDX18(7), DDX19A(2), DDX23(5), DDX4(2), DDX41(6), DDX47(1), DDX50(2), DDX51(2), DDX54(6), DDX55(3), DDX56(4), DHX58(4), ENTPD7(8), EP400(17), ERCC2(4), ERCC3(3), FPGS(1), GGH(1), IFIH1(2), MOV10L1(3), NUDT8(1), QDPR(1), RAD54B(3), RAD54L(2), RUVBL2(2), SETX(8), SKIV2L2(3), SMARCA2(12), SMARCA5(1), SPR(2)	10858822	153	49	153	54	64	41	5	26	17	0	0.331	1.000	1.000
365	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(1), ACADM(1), ACOX1(2), ACOX2(4), ACOX3(4), ACSL1(2), ACSL3(5), ACSL4(2), ACSL5(2), ACSL6(4), ADIPOQ(2), ANGPTL4(2), APOA1(2), APOA5(5), AQP7(1), CD36(2), CPT1A(4), CPT1B(3), CPT1C(2), CPT2(4), CYP27A1(1), CYP4A11(1), CYP4A22(1), CYP7A1(3), CYP8B1(4), DBI(1), EHHADH(2), FABP3(1), FABP5(2), FABP6(3), FABP7(1), FADS2(3), GK(2), GK2(1), HMGCS2(1), ILK(1), LPL(2), ME1(2), MMP1(2), NR1H3(2), OLR1(1), PCK1(2), PCK2(5), PDPK1(1), PLTP(1), PPARA(3), PPARD(4), PPARG(1), RXRA(2), RXRG(3), SCD(1), SCP2(3), SLC27A1(2), SLC27A2(2), SLC27A4(3), SLC27A5(4), SLC27A6(3), SORBS1(5), UBC(3)	11337128	139	49	139	40	49	32	9	35	14	0	0.0435	1.000	1.000
366	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(19), AXIN1(7), CREBBP(10), CTNNB1(10), DVL1(2), EP300(13), FZD1(5), GSK3B(2), HDAC1(2), LDB1(4), LEF1(4), PITX2(2), TRRAP(24), WNT1(3)	5714000	107	49	105	34	39	23	3	18	22	2	0.259	1.000	1.000
367	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(2), APOA1(2), CD36(2), CITED2(1), CPT1B(3), CREBBP(10), DUSP1(1), DUT(1), EHHADH(2), EP300(13), HSD17B4(1), HSPA1A(1), JUN(2), LPL(2), MAPK1(2), MAPK3(1), ME1(2), NCOA1(10), NCOR1(14), NCOR2(13), NR0B2(1), NR1H3(2), NR2F1(3), NRIP1(7), PDGFA(1), PIK3R1(5), PPARA(3), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PTGS2(2), RB1(7), RELA(1), RXRA(2), SP1(3), SRA1(1), STAT5A(1), STAT5B(2), TNF(1)	10554108	140	49	139	44	29	47	5	35	24	0	0.153	1.000	1.000
368	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(4), CAD(5), CANT1(3), CTPS(1), CTPS2(2), DCK(1), DCTD(1), DHODH(1), DPYD(10), DPYS(1), DUT(1), ENTPD1(3), NT5C(1), NUDT2(2), POLD1(7), POLE(12), POLG(3), POLL(1), POLQ(13), POLR2A(8), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(9), RRM1(3), RRM2(2), TK1(1), TK2(3), TXNRD1(4), TYMS(1), UCK1(2), UCK2(1), UMPS(1), UNG(1), UPB1(1)	9906365	117	49	117	48	33	38	5	26	15	0	0.609	1.000	1.000
369	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(2), APC(19), AR(7), ASAH1(2), BRAF(5), CAMP(1), CCL15(1), DAG1(5), EGFR(7), GNA11(4), GNA15(2), GNAI1(1), GNAQ(1), ITPKA(1), ITPKB(5), ITPR1(17), ITPR2(14), ITPR3(16), KCNJ3(5), KCNJ5(2), MAPK1(2), MAPK10(1), MAPK14(1), PHKA2(7), PIK3CD(8), PIK3R1(5), PITX2(2), PTX3(1), RAF1(5)	8883882	149	49	147	48	49	38	10	31	19	2	0.139	1.000	1.000
370	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(5), AGMAT(2), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH4A1(2), ALDH9A1(3), AMD1(2), AOC2(4), AOC3(3), ARG1(2), ASL(3), CKB(1), CKMT1A(2), CKMT1B(2), CKMT2(4), CPS1(14), DAO(5), GATM(2), GLUD1(4), GOT1(1), GOT2(2), MAOA(1), MAOB(3), NOS1(15), NOS3(3), ODC1(2), OTC(2), P4HA1(1), P4HA2(6), P4HA3(1), P4HB(2), PYCR1(2), RARS(2), SMS(2)	7650590	128	48	127	36	46	34	5	32	11	0	0.0452	1.000	1.000
371	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(1), AGT(1), AKT1(2), CALM1(1), CALM2(2), CALM3(1), CALR(3), CAMK1(1), CAMK1G(2), CAMK4(4), CREBBP(10), EDN1(3), ELSPBP1(1), F2(3), FGF2(1), GATA4(3), GSK3B(2), HAND1(3), HAND2(2), IGF1(2), LIF(1), MAP2K1(2), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(3), MEF2C(2), MYH2(10), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NKX2-5(2), NPPA(1), PIK3R1(5), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), RAF1(5), RPS6KB1(2)	8368382	128	48	128	45	39	42	6	21	20	0	0.229	1.000	1.000
372	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(2), AKT2(2), AKT3(3), BAD(1), BCL2(1), BCR(6), BLNK(2), BTK(2), CD19(1), CD22(1), CD81(3), CR2(4), CSK(2), DAG1(5), FLOT1(1), FLOT2(3), GRB2(1), GSK3A(1), GSK3B(2), INPP5D(1), ITPR1(17), ITPR2(14), ITPR3(16), LYN(2), MAP4K1(2), MAPK1(2), MAPK3(1), NFATC1(8), NFATC2(6), NR0B2(1), PDK1(1), PIK3CD(8), PIK3R1(5), PLCG2(6), PPP1R13B(5), PPP3CA(3), PPP3CB(1), PTPRC(14), RAF1(5), SHC1(3), SOS1(3), SOS2(3), SYK(3), VAV1(6)	12480566	179	48	176	55	62	56	5	34	22	0	0.0519	1.000	1.000
373	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), CSK(2), CTLA4(3), DAG1(5), EPHB2(6), FBXW7(8), GRAP2(1), GRB2(1), ITK(4), ITPKA(1), ITPKB(5), LCP2(5), MAPK1(2), NCK1(3), NFAT5(4), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PLCG1(10), PTPRC(14), RAF1(5), RASGRP1(4), RASGRP2(4), RASGRP3(2), RASGRP4(3), SOS1(3), SOS2(3), VAV1(6), ZAP70(2)	9698460	143	48	139	54	42	39	5	36	20	1	0.590	1.000	1.000
374	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH5(1), ADH6(2), ADH7(1), ADHFE1(6), AGK(2), AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPAT6(2), AKR1B1(5), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), CEL(6), DAK(3), DGKA(3), DGKB(4), DGKE(3), DGKH(5), DGKI(5), DGKQ(1), DGKZ(1), GK(2), GK2(1), GLB1(2), GPAM(4), LCT(7), LIPA(1), LIPC(2), LIPF(1), LIPG(2), LPL(2), PNLIP(1), PNLIPRP1(2), PNLIPRP2(2), PNPLA3(1), PPAP2C(4)	10193044	118	47	117	46	33	43	2	25	15	0	0.382	1.000	1.000
375	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	67	AKT1(2), AKT2(2), AKT3(3), BAD(1), CASP9(1), CDC42(1), KDR(4), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK13(1), MAPK14(1), MAPK3(1), MAPKAPK3(1), NFAT5(4), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NOS3(3), NRAS(1), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCG1(10), PLCG2(6), PPP3CA(3), PPP3CB(1), PPP3R2(1), PRKCG(4), PTGS2(2), PTK2(7), PXN(1), RAC2(1), RAC3(1), RAF1(5), SH2D2A(2), SHC2(2), SPHK1(3)	11965424	159	47	156	59	56	53	6	29	15	0	0.278	1.000	1.000
376	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(2), AKT2(2), AKT3(3), BLNK(2), BTK(2), CARD11(9), CD19(1), CD22(1), CD79A(5), CD81(3), CR2(4), FCGR2B(1), GSK3B(2), IFITM1(1), IKBKB(3), INPP5D(1), JUN(2), LILRB3(2), LYN(2), MALT1(4), NFAT5(4), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NFKB1(5), NFKB2(3), NFKBIB(4), NRAS(1), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PLCG2(6), PPP3CA(3), PPP3CB(1), PPP3R2(1), PTPN6(3), RAC2(1), RAC3(1), RASGRP3(2), SYK(3), VAV1(6), VAV2(8), VAV3(6)	12453499	171	47	170	69	58	59	3	31	20	0	0.496	1.000	1.000
377	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	72	AKT1(2), AKT2(2), AKT3(3), BTK(2), FYN(5), GRB2(1), IL13(1), IL3(1), INPP5D(1), LCP2(5), LYN(2), MAP2K1(2), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP2K6(1), MAP2K7(12), MAPK1(2), MAPK10(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPK9(3), NRAS(1), PDK1(1), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCG1(10), PLCG2(6), PRKCD(3), PRKCE(5), RAC2(1), RAC3(1), RAF1(5), SOS1(3), SOS2(3), SYK(3), TNF(1), VAV1(6), VAV2(8), VAV3(6)	12013988	175	47	173	63	59	59	2	40	15	0	0.296	1.000	1.000
378	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	ACTA1(1), CRK(1), DOCK1(10), ELK1(2), GAB1(1), GRB2(1), HGF(12), ITGA1(3), ITGB1(4), JUN(2), MAP2K1(2), MAP2K2(1), MAP4K1(2), MAPK1(2), MAPK3(1), MAPK8(3), MET(4), PAK1(4), PIK3R1(5), PTEN(8), PTK2(7), PTK2B(5), PTPN11(4), PXN(1), RAF1(5), RAP1A(2), RAP1B(3), RASA1(9), SOS1(3), STAT3(6)	7316569	114	47	110	38	26	34	4	27	22	1	0.344	1.000	1.000
379	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	BAK1(2), BFAR(1), BTK(2), CAD(5), CASP10(3), CASP3(1), CASP8(5), CASP8AP2(6), CD7(3), DAXX(3), DEDD(1), DEDD2(1), DFFA(2), DIABLO(1), EGFR(7), EPHB2(6), FAF1(4), FAIM2(1), HSPB1(1), IL8(1), MAP2K4(5), MAP2K7(12), MAP3K1(6), MAP3K5(3), MAPK1(2), MAPK10(1), MAPK8(3), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(7), MAPK9(3), MET(4), NFAT5(4), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), NR0B2(1), PFN2(2), PTPN13(12), RALBP1(4), ROCK1(7), SMPD1(3), TPX2(3), TRAF2(2), TUFM(2)	12550449	162	47	161	61	56	47	5	35	19	0	0.398	1.000	1.000
380	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(3), AKT1(2), APC(19), ASAH1(2), CAMP(1), DAG1(5), DLG4(3), EPHB2(6), GNAI1(1), GNAQ(1), ITPR1(17), ITPR2(14), ITPR3(16), KCNJ3(5), KCNJ5(2), MAPK1(2), PITX2(2), PTX3(1), RHO(2), RYR1(27)	7983844	131	47	130	49	54	29	7	24	16	1	0.331	1.000	1.000
381	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(4), AASS(2), ACAT1(2), ACAT2(2), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), BBOX1(1), DLST(1), DOT1L(7), EHHADH(2), EHMT1(6), EHMT2(3), GCDH(3), HADH(2), HADHA(2), HSD17B4(1), HSD3B7(3), NSD1(10), OGDH(6), OGDHL(3), PIPOX(2), PLOD1(5), PLOD2(3), PLOD3(4), RDH11(1), RDH12(1), SETD1A(6), SETDB1(8), SHMT1(1), SHMT2(3), SPCS3(1), SUV39H1(4), SUV39H2(1), TMLHE(3)	10026846	122	46	120	42	36	42	5	21	18	0	0.204	1.000	1.000
382	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(3), B3GALNT1(1), B3GALT1(2), B3GALT2(5), B3GALT4(2), B3GALT5(1), B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(2), B3GNT5(1), B4GALNT1(1), B4GALT1(2), B4GALT2(5), B4GALT4(3), B4GALT6(1), FUT1(1), FUT4(1), FUT7(1), FUT9(2), PIGA(1), PIGB(4), PIGC(2), PIGG(5), PIGK(1), PIGL(1), PIGM(4), PIGN(2), PIGO(1), PIGQ(1), PIGS(1), PIGT(2), PIGV(3), PIGX(2), PIGZ(2), ST3GAL1(2), ST3GAL2(4), ST3GAL4(3), ST3GAL5(1), ST3GAL6(2), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC5(1), ST6GALNAC6(3), ST8SIA1(3), ST8SIA5(2)	8396053	94	46	93	38	35	29	3	21	5	1	0.513	1.000	1.000
383	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(3), ACTN2(11), ACTN3(1), BCAR1(4), BCR(6), CAPN1(2), CAPNS1(1), CAPNS2(1), CAV1(2), CSK(2), FYN(5), GRB2(1), ITGA1(3), ITGB1(4), JUN(2), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MAPK8(3), PPP1R12B(6), PTK2(7), PXN(1), RAF1(5), RAP1A(2), ROCK1(7), SHC1(3), SOS1(3), TLN1(11), VCL(2), ZYX(2)	8123235	107	46	105	45	38	30	3	26	10	0	0.708	1.000	1.000
384	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(13), BMPR1B(2), DMC1(1), EGR1(3), ESR2(5), FSHR(12), GJA4(3), INHA(2), LHCGR(7), MLH1(3), MSH5(3), NCOR1(14), NR5A1(5), NRIP1(7), PGR(6), PRLR(1), PTGER2(2), SMPD1(3), VDR(3), ZP2(4)	6056457	99	46	96	31	26	34	5	22	11	1	0.168	1.000	1.000
385	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(8), ATP4A(5), ATP4B(1), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5G3(1), ATP5J(1), ATP5J2(1), ATP5L(1), ATP6AP1(3), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(4), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), COX10(1), COX15(3), COX4I1(3), COX4I2(1), COX6B1(1), COX7A2(2), COX7C(1), LHPP(2), NDUFA1(1), NDUFA10(1), NDUFA13(1), NDUFA3(1), NDUFA6(1), NDUFA8(1), NDUFA9(2), NDUFAB1(1), NDUFB2(1), NDUFB7(1), NDUFB8(1), NDUFB9(1), NDUFC2(2), NDUFS1(4), NDUFS2(2), NDUFS6(1), NDUFS7(1), NDUFS8(3), NDUFV1(1), PPA2(1), SDHA(5), SDHB(3), SDHC(1), TCIRG1(4), UQCRB(1), UQCRC1(2), UQCRC2(2), UQCRFS1(1), UQCRQ(1)	9640904	123	45	123	58	36	45	5	30	7	0	0.876	1.000	1.000
386	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH6(2), ADH7(1), ADHFE1(6), AGPAT1(1), AGPAT3(2), AGPAT4(5), AKR1B1(5), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), CEL(6), DGKA(3), DGKB(4), DGKE(3), DGKH(5), DGKQ(1), DGKZ(1), GK(2), GLB1(2), LCT(7), LIPC(2), LIPF(1), LIPG(2), LPL(2), PNLIP(1), PNLIPRP1(2), PNLIPRP2(2), PPAP2C(4)	8378947	105	44	104	48	32	36	1	22	14	0	0.724	1.000	1.000
387	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(5), AGXT(1), AGXT2(5), ALAS1(1), ALAS2(4), AMT(4), AOC2(4), AOC3(3), BHMT(3), CBS(3), CHDH(3), CHKA(1), CHKB(2), CPT1B(3), CTH(2), DAO(5), DLD(2), DMGDH(5), GARS(1), GATM(2), GCAT(2), GLDC(5), MAOA(1), MAOB(3), PEMT(1), PISD(4), PLCB2(3), PLCG1(10), PLCG2(6), PSPH(2), SARDH(4), SARS(2), SHMT1(1), SHMT2(3), TARS(4)	7269557	110	44	109	39	31	26	7	33	13	0	0.449	1.000	1.000
388	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(7), AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPAT6(2), CDS1(3), CDS2(1), CHAT(1), CHKA(1), CHKB(2), CHPT1(1), DGKA(3), DGKB(4), DGKE(3), DGKH(5), DGKI(5), DGKQ(1), DGKZ(1), ESCO2(1), ETNK2(1), GNPAT(1), GPAM(4), GPD1(3), GPD1L(3), GPD2(3), LCAT(1), LYPLA2(1), MYST3(8), MYST4(10), NAT6(2), PCYT1A(7), PCYT1B(3), PEMT(1), PISD(4), PLA2G10(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLD1(7), PLD2(10), PNPLA3(1), PPAP2C(4), PTDSS1(1), PTDSS2(2), SH3GLB1(1)	11319685	145	44	144	51	52	48	6	28	11	0	0.183	1.000	1.000
389	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	43	AKT1(2), AKT2(2), AKT3(3), BRAF(5), EIF4B(2), EIF4EBP1(1), HIF1A(2), IGF1(2), MAPK1(2), MAPK3(1), PDPK1(1), PIK3CB(5), PIK3CD(8), PIK3CG(9), PIK3R1(5), PIK3R2(4), PIK3R3(1), PIK3R5(3), PRKAA1(1), PRKAA2(2), RHEB(1), RICTOR(8), RPS6(1), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KA6(7), RPS6KB1(2), RPS6KB2(2), TSC1(3), TSC2(3), ULK1(9), ULK2(4), VEGFC(3)	8827821	117	44	116	50	47	33	6	21	10	0	0.747	1.000	1.000
390	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(2), BAD(1), BCL2(1), CASP1(1), CASP10(3), CASP2(2), CASP3(1), CASP4(2), CASP6(1), CASP7(2), CASP8(5), CASP9(1), CD40(1), CD40LG(4), DAXX(3), DFFA(2), DFFB(2), FAS(2), IKBKE(5), LTA(2), NFKB1(5), NGFR(4), NR3C1(4), NTRK1(3), PTPN13(12), SFRS2IP(5), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF1(2), TRAF2(2), TRAF3(2), TRAF6(4)	7575765	90	43	90	36	20	28	8	26	8	0	0.654	1.000	1.000
391	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(7), CARM1(2), CCND1(1), CREBBP(10), EP300(13), ERCC3(3), ESR1(4), GRIP1(5), GTF2A1(2), GTF2E1(4), GTF2F1(1), HDAC1(2), HDAC2(2), HDAC3(3), HDAC4(7), HDAC5(4), HDAC6(1), MEF2C(2), NCOR2(13), NR0B1(2), NRIP1(7), PELP1(5), POLR2A(8), SRA1(1), TBP(1)	7956617	110	43	109	33	36	30	4	22	18	0	0.104	1.000	1.000
392	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(3), ADC(1), ALDH4A1(2), ALDH5A1(2), CAD(5), CPS1(14), EARS2(1), EPRS(6), GAD1(3), GAD2(3), GCLM(2), GFPT1(2), GFPT2(2), GLS(4), GLS2(4), GLUD1(4), GLUD2(6), GLUL(1), GMPS(2), GOT1(1), GOT2(2), GPT2(2), GSR(4), GSS(1), NADSYN1(3), PPAT(1), QARS(4)	6843004	85	43	84	34	26	27	4	24	4	0	0.623	1.000	1.000
393	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(2), AARS2(4), ABAT(3), ACY3(1), ADSL(2), ADSS(3), ADSSL1(6), AGXT(1), AGXT2(5), ASL(3), ASNS(3), ASRGL1(1), ASS1(4), CAD(5), CRAT(3), DARS(1), DDO(2), DLAT(3), DLD(2), GAD1(3), GAD2(3), GOT1(1), GOT2(2), GPT2(2), NARS(3), PC(5), PDHA1(1), PDHA2(4), PDHB(2)	6539234	80	43	79	33	33	21	1	22	3	0	0.643	1.000	1.000
394	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(4), AANAT(1), ABP1(5), ACAT1(2), ACAT2(2), ACMSD(2), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), AOC2(4), AOC3(3), AOX1(2), ASMT(1), CARM1(2), CAT(4), CYP1A1(1), CYP1A2(3), CYP1B1(2), DDC(3), EHHADH(2), GCDH(3), HADH(2), HADHA(2), HSD17B4(1), INMT(1), KYNU(6), LCMT1(1), LCMT2(6), LNX1(4), MAOA(1), MAOB(3), METTL6(1), NFX1(1), OGDH(6), OGDHL(3), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(3), TDO2(2), TPH1(1), TPH2(1), WARS(3), WARS2(5), WBSCR22(2)	10475349	130	43	126	41	32	42	8	26	21	1	0.105	1.000	1.000
395	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(2), AKT2(2), AKT3(3), BAD(1), BCR(6), BLNK(2), BTK(2), CD19(1), CSK(2), DAG1(5), EPHB2(6), GRB2(1), ITPKA(1), ITPKB(5), LYN(2), MAP2K1(2), MAP2K2(1), MAPK1(2), NFAT5(4), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PI3(1), PIK3CD(8), PIK3R1(5), PLCG2(6), PPP1R13B(5), RAF1(5), SERPINA4(2), SHC1(3), SOS1(3), SOS2(3), SYK(3), VAV1(6)	8746556	118	43	117	37	38	37	1	22	19	1	0.173	1.000	1.000
396	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(6), AKT1(2), AKT2(2), AKT3(3), DAG1(5), GNAQ(1), ITPKA(1), ITPKB(5), ITPR1(17), ITPR2(14), ITPR3(16), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PDK1(1), PHKA2(7), PIK3CB(5), PITX2(2), PLD1(7), PLD2(10), PLD3(5), VN1R1(3)	7798475	130	43	130	37	41	39	8	29	12	1	0.0550	1.000	1.000
397	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(7), AMY2A(2), AMY2B(3), ENPP1(1), ENPP3(2), GAA(2), GANAB(3), GBA3(1), GBE1(2), GCK(3), GPI(4), GUSB(2), GYS1(4), GYS2(2), HK1(5), HK2(5), HK3(3), MGAM(6), PGM1(2), PGM3(6), PYGB(4), PYGL(3), PYGM(5), SI(10), UCHL1(2), UCHL3(3), UGDH(4), UGT1A1(1), UGT1A5(3), UGT2B15(1), UGT2B4(2), UXS1(3)	9913319	106	43	106	36	30	38	3	16	19	0	0.238	1.000	1.000
398	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	BAG4(1), CASP2(2), CASP3(1), CASP8(5), DFFA(2), DFFB(2), JUN(2), LMNA(5), LMNB1(1), LMNB2(2), MADD(4), MAP2K4(5), MAP3K1(6), MAP3K7(6), MAPK8(3), PAK1(4), PAK2(5), PRKDC(19), RB1(7), SPTAN1(10), TNF(1), TNFRSF1A(2), TRAF2(2)	6797948	97	43	96	32	26	33	4	20	14	0	0.220	1.000	1.000
399	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(3), CASP3(1), CASP6(1), CASP7(2), CASP8(5), DAXX(3), DFFA(2), DFFB(2), FAF1(4), JUN(2), LMNA(5), LMNB1(1), LMNB2(2), MAP2K4(5), MAP3K1(6), MAP3K7(6), MAPK8(3), PAK1(4), PAK2(5), PRKDC(19), PTPN13(12), RB1(7), RIPK2(1), SPTAN1(10)	7204437	111	42	110	33	26	39	4	24	18	0	0.145	1.000	1.000
400	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(6), ACSS2(3), ACYP2(1), ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH5(1), ADH6(2), ADH7(1), ADHFE1(6), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(3), ALDOB(2), ALDOC(2), BPGM(1), DLAT(3), DLD(2), ENO1(2), ENO2(1), ENO3(2), FBP1(1), FBP2(3), GALM(1), GAPDH(1), GAPDHS(2), GCK(3), GPI(4), HK1(5), HK2(5), HK3(3), LDHAL6B(2), LDHB(1), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKL(4), PFKM(2), PFKP(7), PGAM2(2), PGAM4(1), PGK1(1), PGK2(1), PGM1(2), PGM3(6), PKLR(4), PKM2(2), TPI1(2)	10051406	138	42	137	55	44	43	6	32	13	0	0.422	1.000	1.000
401	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(14), ACACB(10), ACAT1(2), ACAT2(2), ACOT12(4), ACSS1(6), ACSS2(3), ACYP2(1), AKR1B1(5), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), DLAT(3), DLD(2), GRHPR(2), HAGH(1), LDHAL6B(2), LDHB(1), LDHC(1), LDHD(1), MDH1(3), ME1(2), ME2(3), ME3(4), PC(5), PCK1(2), PCK2(5), PDHA1(1), PDHA2(4), PDHB(2), PKLR(4), PKM2(2)	8073060	116	42	116	34	38	31	4	29	14	0	0.0852	1.000	1.000
402	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(1), DAXX(3), EGF(4), EGFR(7), ETS1(4), ETS2(1), HOXA7(1), IKBKB(3), JUN(2), MAP2K1(2), MAP2K3(1), MAP2K4(5), MAP2K6(1), MAP2K7(12), MAP3K1(6), MAP3K14(2), MAP3K5(3), MAPK1(2), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(3), NFKB1(5), PPP2CA(3), PRKCD(3), PRKCE(5), PRKCG(4), PRKCH(5), PRKCQ(2), RAF1(5), RELA(1), SP1(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(2)	8491769	108	42	107	42	37	29	1	27	14	0	0.464	1.000	1.000
403	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(17), B3GALT4(2), CDR1(4), DGKI(5), IL6ST(2), PIGK(1), RPL10(2), RPL12(1), RPL13A(1), RPL14(1), RPL18A(1), RPL19(2), RPL3(2), RPL31(1), RPL34(1), RPL36(1), RPL5(1), RPL6(1), RPL7A(3), RPL8(2), RPL9(2), RPLP0(3), RPLP1(1), RPS10(1), RPS11(1), RPS13(1), RPS14(2), RPS23(1), RPS27A(1), RPS3(1), RPS3A(1), RPS5(2), RPS6(1), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KA6(7), RPS6KB1(2), RPS6KB2(2), RPSA(3), SLC36A2(4), TBC1D10C(1), TSPAN9(1), UBC(3)	9036834	105	42	105	39	25	38	7	24	10	1	0.565	1.000	1.000
404	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(2), CDC42(1), DLD(2), DUSP10(3), DUSP4(1), DUSP8(1), GAB1(1), GCK(3), IL1R1(3), JUN(2), MAP2K4(5), MAP2K7(12), MAP3K1(6), MAP3K10(6), MAP3K11(2), MAP3K12(4), MAP3K13(3), MAP3K2(1), MAP3K3(2), MAP3K4(8), MAP3K5(3), MAP3K7(6), MAP3K9(5), MAPK10(1), MAPK7(6), MAPK8(3), MAPK9(3), MYEF2(4), NFATC3(2), NR2C2(2), PAPPA(12), SHC1(3), TRAF6(4), ZAK(3)	8570347	125	42	125	38	38	39	6	23	19	0	0.114	1.000	1.000
405	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(5), EEF1B2(1), EEF1D(3), EEF1G(3), EEF2(2), EEF2K(6), EIF1AX(1), EIF1AY(1), EIF2AK1(1), EIF2AK2(2), EIF2AK3(8), EIF2B1(3), EIF2B3(3), EIF2B4(5), EIF2B5(3), EIF2S1(1), EIF2S2(2), EIF4A1(1), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4EBP2(1), EIF4G1(8), EIF4G3(4), EIF5(3), EIF5A(2), EIF5B(6), ETF1(3), GSPT2(1), KIAA0664(8), PABPC1(3), PABPC3(5), PAIP1(1), SLC35A4(3)	7561690	104	42	102	33	36	35	3	23	7	0	0.146	1.000	1.000
406	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(5), AGXT(1), AGXT2(5), ALAS1(1), ALAS2(4), AMT(4), AOC2(4), AOC3(3), BHMT(3), CBS(3), CHDH(3), CHKA(1), CHKB(2), CTH(2), DAO(5), DLD(2), DMGDH(5), GARS(1), GATM(2), GCAT(2), GLDC(5), GNMT(2), HSD3B7(3), MAOA(1), MAOB(3), PEMT(1), PIPOX(2), PISD(4), PSAT1(2), PSPH(2), RDH11(1), RDH12(1), SARDH(4), SARS(2), SARS2(3), SDS(1), SHMT1(1), SHMT2(3), TARS(4), TARS2(4)	7387435	107	41	107	37	33	25	8	29	12	0	0.328	1.000	1.000
407	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH5(1), ADH6(2), ADH7(1), ADHFE1(6), AKR1C3(3), AKR1C4(3), ALDH1A3(5), ALDH3A1(3), ALDH3B2(4), CYP1A1(1), CYP1A2(3), CYP1B1(2), CYP2B6(2), CYP2C18(3), CYP2C19(6), CYP2E1(3), CYP2F1(1), CYP2S1(2), CYP3A4(1), CYP3A43(3), CYP3A7(2), DHDH(5), EPHX1(3), GSTA1(2), GSTA2(1), GSTA4(1), GSTA5(1), GSTM3(1), GSTM4(1), GSTO2(2), GSTP1(1), GSTZ1(3), MGST1(1), MGST3(1), UGT1A1(1), UGT1A5(3), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2)	9741758	108	41	107	33	25	37	2	30	14	0	0.134	1.000	1.000
408	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CALM1(1), CALM2(2), CALM3(1), CD3E(2), CD3G(2), ELK1(2), FYN(5), GRB2(1), JUN(2), MAP2K1(2), MAP2K4(5), MAP3K1(6), MAPK3(1), MAPK8(3), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), NFKB1(5), PIK3R1(5), PLCG1(10), PPP3CA(3), PPP3CB(1), PTPN7(2), RAF1(5), RASA1(9), RELA(1), SHC1(3), SOS1(3), VAV1(6), ZAP70(2)	7877380	116	41	113	32	33	37	2	19	24	1	0.0796	1.000	1.000
409	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(3), ACTN2(11), ACTN3(1), CAPN1(2), CAPNS1(1), CAPNS2(1), ITGA1(3), ITGB1(4), ITGB3(3), PTK2(7), PXN(1), SPTAN1(10), TLN1(11)	4925910	59	41	57	33	27	13	3	12	4	0	0.933	1.000	1.000
410	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(3), INPP4A(1), INPP4B(3), INPP5A(3), INPPL1(12), ITPKA(1), ITPKB(5), OCRL(4), PIK3C2A(4), PIK3C2B(10), PIK3C2G(3), PIK3CB(5), PIK3CG(9), PLCB1(10), PLCB2(3), PLCB3(6), PLCB4(6), PLCD1(1), PLCG1(10), PLCG2(6)	7414586	105	40	103	32	34	36	1	21	12	1	0.192	1.000	1.000
411	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(8), ATP4B(1), ATP6AP1(3), ATP6V0A1(4), ATP6V0A4(4), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), ATP7A(5), ATP7B(8), COX10(1), COX4I1(3), COX6B1(1), COX7A2(2), COX7C(1), NDUFA1(1), NDUFA10(1), NDUFA8(1), NDUFB2(1), NDUFB7(1), NDUFS1(4), NDUFS2(2), NDUFV1(1), PPA2(1), SDHA(5), SDHB(3), SHMT1(1), UQCRB(1), UQCRC1(2), UQCRFS1(1)	6589629	93	40	93	35	27	34	3	22	7	0	0.439	1.000	1.000
412	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(6), ACTR2(2), AKT1(2), ANGPTL2(4), CDC42(1), CFL1(1), FLNA(10), FLNC(13), FSCN1(5), FSCN3(8), GDI1(1), LIMK1(3), MYH2(10), MYLK(7), MYLK2(2), PAK1(4), PAK2(5), PAK3(1), PAK4(4), PAK6(2), PAK7(2), PFN2(2), RHO(2), ROCK1(7), ROCK2(2), VASP(2), WASF1(3), WASL(1)	8284558	112	40	112	37	42	34	5	21	10	0	0.103	1.000	1.000
413	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	41	AKT1(2), ASAH1(2), BRAF(5), CAMP(1), CREB1(4), CREB3(2), CREB5(1), CREBBP(10), DAG1(5), EGR1(3), EGR2(3), EGR3(1), EGR4(4), ELK1(2), FRS2(2), GNAQ(1), JUN(2), MAP1B(7), MAP2K4(5), MAP2K7(12), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(3), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(7), MAPK9(3), NTRK1(3), OPN1LW(4), PIK3C2G(3), PIK3CD(8), PIK3R1(5), PTPN11(4), RPS6KA3(1), SHC1(3), TERF2IP(3), TH(1)	8510850	128	40	127	49	45	38	1	22	22	0	0.419	1.000	1.000
414	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	32	A1BG(1), AKT1(2), AKT2(2), AKT3(3), BAD(1), BTK(2), CDKN2A(3), GRB2(1), GSK3A(1), GSK3B(2), IARS(6), IGFBP1(2), INPP5D(1), PDK1(1), PPP1R13B(5), PTEN(8), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), RPS6KB1(2), SHC1(3), SOS1(3), SOS2(3), TEC(3), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1)	5862380	72	40	72	27	20	25	0	16	11	0	0.558	1.000	1.000
415	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	64	APAF1(2), BAD(1), BAK1(2), BCL2(1), BCL2L11(1), BID(1), BIRC2(2), BIRC3(3), BIRC5(1), CASP1(1), CASP10(3), CASP2(2), CASP3(1), CASP4(2), CASP6(1), CASP7(2), CASP8(5), CASP9(1), DFFA(2), DFFB(2), FAS(2), HELLS(3), IKBKB(3), IRF1(1), IRF4(2), IRF5(2), IRF6(2), IRF7(1), JUN(2), LTA(2), MAP2K4(5), MAP3K1(6), MAPK10(1), MDM2(3), NFKB1(5), NFKBIB(4), PLEKHG5(4), PRF1(1), RELA(1), TNF(1), TNFRSF10B(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TNFRSF25(1), TNFSF10(2), TP73(1), TRAF1(2), TRAF2(2), TRAF3(2)	9651170	105	39	105	35	33	31	4	22	15	0	0.224	1.000	1.000
416	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(3), ALDH4A1(2), ALDH5A1(2), CAD(5), CPS1(14), EPRS(6), GAD1(3), GAD2(3), GCLM(2), GFPT1(2), GLS(4), GLS2(4), GLUD1(4), GLUL(1), GMPS(2), GOT1(1), GOT2(2), GPT2(2), GSS(1), NADSYN1(3), PPAT(1), QARS(4)	5751199	71	39	70	26	21	24	3	19	4	0	0.506	1.000	1.000
417	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(7), AGPAT1(1), AGPAT3(2), AGPAT4(5), AGPS(2), CDS1(3), CDS2(1), CHAT(1), CHKA(1), CHKB(2), CLC(2), CPT1B(3), DGKA(3), DGKB(4), DGKE(3), DGKH(5), DGKQ(1), DGKZ(1), GNPAT(1), GPD1(3), GPD2(3), LCAT(1), LYPLA2(1), PAFAH1B1(3), PAFAH2(1), PCYT1A(7), PCYT1B(3), PEMT(1), PISD(4), PLA2G2E(1), PLA2G3(7), PLA2G4A(3), PLA2G6(3), PLCB2(3), PLCG1(10), PLCG2(6), PPAP2C(4)	8656566	112	39	110	40	46	35	2	21	8	0	0.230	1.000	1.000
418	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), AADAC(2), ABAT(3), ACADS(1), ACAT1(2), ACAT2(2), ACSM1(1), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH5A1(2), ALDH9A1(3), BDH1(1), DDHD1(7), EHHADH(2), GAD1(3), GAD2(3), HADH(2), HADHA(2), HMGCS1(1), HMGCS2(1), HSD17B4(1), HSD3B7(3), ILVBL(1), L2HGDH(1), OXCT1(3), PDHA1(1), PDHA2(4), PDHB(2), PRDX6(1), RDH11(1), RDH12(1)	7029026	75	39	72	29	25	19	1	23	7	0	0.510	1.000	1.000
419	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(2), AARS2(4), CARS(2), CARS2(1), DARS(1), EARS2(1), EPRS(6), FARS2(5), FARSA(2), FARSB(1), GARS(1), HARS(3), HARS2(2), IARS(6), IARS2(3), KARS(2), LARS(2), LARS2(5), MARS(2), MARS2(1), NARS(3), QARS(4), RARS(2), SARS(2), SARS2(3), TARS(4), TARS2(4), VARS(7), VARS2(4), WARS(3), WARS2(5), YARS(1), YARS2(1)	9394027	95	39	95	39	32	32	3	25	3	0	0.738	1.000	1.000
420	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(6), BLNK(2), ELK1(2), GRB2(1), JUN(2), LYN(2), MAP2K1(2), MAP3K1(6), MAPK1(2), MAPK3(1), MAPK8IP3(7), PAPPA(12), RPS6KA1(6), RPS6KA3(1), SHC1(3), SOS1(3), SYK(3), VAV1(6), VAV2(8), VAV3(6)	5547810	81	39	81	31	26	26	2	16	11	0	0.480	1.000	1.000
421	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), AKT2(2), AKT3(3), ARHGEF11(10), BCL2(1), CDC42(1), DLG4(3), LPA(10), MAP2K4(5), MAP3K1(6), MAP3K5(3), MAPK8(3), NFKB1(5), NFKB2(3), NFKBIB(4), NFKBIL2(6), PDK1(1), PHKA2(7), PI3(1), PIK3CB(5), PLD1(7), PLD2(10), PLD3(5), PTK2(7), RDX(2), ROCK1(7), ROCK2(2), SERPINA4(2), TBXA2R(6)	8507934	129	39	129	40	43	40	8	23	15	0	0.121	1.000	1.000
422	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(2), CDC7(3), CDK2(2), CDT1(2), DIAPH2(3), MCM10(5), MCM2(8), MCM3(1), MCM4(6), MCM5(6), MCM7(4), NACA(1), ORC1L(6), ORC2L(1), ORC3L(4), ORC4L(3), ORC5L(1), ORC6L(3), PCNA(2), POLA2(2), POLD1(7), POLD3(1), POLE(12), POLE2(1), PRIM1(1), RFC1(1), RFC2(1), RFC3(2), RFC4(1), RPA1(1), RPA2(1), RPA3(1), RPS27A(1), UBC(3)	8813560	99	38	99	43	32	24	6	20	17	0	0.790	1.000	1.000
423	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH6(2), ADH7(1), ADHFE1(6), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(3), ALDOB(2), ALDOC(2), BPGM(1), DLAT(3), DLD(2), ENO1(2), ENO2(1), ENO3(2), FBP1(1), FBP2(3), GAPDH(1), GCK(3), GPI(4), HK1(5), HK2(5), HK3(3), LDHB(1), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKM(2), PFKP(7), PGK1(1), PGM1(2), PGM3(6), PKLR(4), PKM2(2), TPI1(2)	8436122	122	38	121	51	38	37	4	31	12	0	0.589	1.000	1.000
424	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(2), ADH1B(1), ADH1C(3), ADH4(1), ADH6(2), ADH7(1), ADHFE1(6), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH3B2(4), ALDH9A1(3), ALDOB(2), ALDOC(2), BPGM(1), DLAT(3), DLD(2), ENO1(2), ENO2(1), ENO3(2), FBP1(1), FBP2(3), GAPDH(1), GCK(3), GPI(4), HK1(5), HK2(5), HK3(3), LDHB(1), LDHC(1), PDHA1(1), PDHA2(4), PDHB(2), PFKM(2), PFKP(7), PGK1(1), PGM1(2), PGM3(6), PKLR(4), PKM2(2), TPI1(2)	8436122	122	38	121	51	38	37	4	31	12	0	0.589	1.000	1.000
425	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(10), CALM1(1), CALM2(2), CALM3(1), CREB1(4), ELK1(2), GNAI1(1), GNAQ(1), GNAS(11), GNGT1(3), JUN(2), MAP2K1(2), MAPK3(1), NFATC1(8), NFATC2(6), NFATC3(2), NFATC4(10), PLCG1(10), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), RAF1(5), RPS6KA3(1)	6022676	100	38	99	31	36	38	0	16	10	0	0.0995	1.000	1.000
426	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(3), ALG10(5), ALG10B(1), ALG12(1), ALG13(2), ALG3(1), ALG8(1), ALG9(2), B4GALT1(2), B4GALT2(5), DOLPP1(2), DPM1(1), FUT8(2), GANAB(3), MAN1A2(1), MAN1B1(2), MAN1C1(3), MAN2A1(2), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(1), MGAT5(5), MGAT5B(1), RFT1(1), RPN1(1), RPN2(3), STT3B(3)	7362545	65	38	64	38	19	17	4	15	10	0	0.992	1.000	1.000
427	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(3), CREBBP(10), CTBP1(2), CTBP2(3), DLL1(3), DLL3(2), DLL4(1), DTX1(7), DTX2(2), DTX3L(1), DTX4(3), DVL1(2), DVL2(2), DVL3(4), EP300(13), HDAC1(2), HDAC2(2), JAG1(3), JAG2(1), MAML1(4), MAML2(5), MAML3(7), NCOR2(13), NCSTN(2), NOTCH1(12), NOTCH2(8), NOTCH3(8), NOTCH4(6), NUMB(2), NUMBL(2), PSEN1(1), PSEN2(2), PSENEN(1), RBPJ(2), RBPJL(3), RFNG(1)	11912577	145	38	144	67	54	41	6	25	19	0	0.735	1.000	1.000
428	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	72	B2M(2), CALR(3), CANX(1), CD4(2), CD74(1), CD8A(2), CD8B(1), CIITA(5), CREB1(4), CTSL1(2), CTSS(1), HLA-A(6), HLA-C(3), HLA-DMA(1), HLA-DMB(2), HLA-DOA(1), HLA-DPA1(2), HLA-DPB1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(3), HLA-DRB1(1), HLA-E(2), HLA-F(4), HLA-G(2), HSP90AA1(2), HSP90AB1(2), IFI30(1), IFNA1(1), IFNA10(1), IFNA16(1), IFNA17(3), IFNA5(2), IFNA7(2), IFNA8(1), KIR2DL1(3), KIR2DL3(1), KIR2DL4(1), KIR2DS4(1), KIR3DL1(2), KLRC1(2), KLRC2(2), KLRD1(2), LGMN(4), LTA(2), PDIA3(1), PSME2(1), RFX5(2), RFXANK(3), TAP1(3), TAP2(6), TAPBP(1)	7928815	107	38	105	37	17	42	9	25	14	0	0.347	1.000	1.000
429	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	CDK5(2), CDK5R1(1), CFL1(1), CHN1(4), LIMK1(3), MAP3K1(6), MYL2(1), MYLK(7), NCF2(1), PAK1(4), PDGFRA(3), PIK3R1(5), PLD1(7), PPP1R12B(6), RALBP1(4), RPS6KB1(2), TRIO(17), VAV1(6), WASF1(3)	5671547	83	38	82	35	27	25	2	16	12	1	0.753	1.000	1.000
430	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(5), ACAT1(2), ACAT2(2), ACMSD(2), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), AOC2(4), AOC3(3), AOX1(2), ASMT(1), CAT(4), CYP19A1(5), CYP1A1(1), CYP1A2(3), CYP2A13(4), CYP2A6(1), CYP2A7(2), CYP2B6(2), CYP2C18(3), CYP2C19(6), CYP2D6(3), CYP2E1(3), CYP2F1(1), CYP2J2(2), CYP3A4(1), CYP3A7(2), CYP4B1(1), CYP4F8(1), CYP51A1(2), DDC(3), EHHADH(2), GCDH(3), HADHA(2), KYNU(6), MAOA(1), MAOB(3), SDS(1), TDO2(2), TPH1(1), WARS(3), WARS2(5)	9529980	127	37	124	41	37	40	5	29	15	1	0.144	1.000	1.000
431	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(10), CD3E(2), CD3G(2), CD4(2), CREBBP(10), CSK(2), GNAS(11), GNGT1(3), HLA-DRA(3), HLA-DRB1(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PTPRC(14), ZAP70(2)	3964866	75	36	73	34	18	25	2	16	14	0	0.879	1.000	1.000
432	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(10), CD3E(2), CD3G(2), CD4(2), CREBBP(10), CSK(2), GNAS(11), GNGT1(3), HLA-DRA(3), HLA-DRB1(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PTPRC(14), ZAP70(2)	3964866	75	36	73	34	18	25	2	16	14	0	0.879	1.000	1.000
433	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(13), ATR(5), BRCA1(7), CCNB1(1), CDC25A(2), CDC25B(2), CDC25C(2), CDC34(1), CDKN1A(1), CDKN2D(1), CHEK1(1), CHEK2(5), EP300(13), MDM2(3), MYT1(9), PRKDC(19), RPS6KA1(6), YWHAH(1), YWHAQ(1)	7212155	93	36	92	31	30	35	2	14	11	1	0.350	1.000	1.000
434	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(3), AKR1D1(1), ARSD(1), ARSE(3), CARM1(2), CYP11B1(2), CYP11B2(2), CYP19A1(5), HSD11B2(2), HSD17B1(3), HSD17B12(2), HSD17B3(1), HSD17B7(1), HSD3B1(1), HSD3B2(1), LCMT1(1), LCMT2(6), METTL6(1), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(3), SRD5A1(2), SRD5A2(2), STS(2), SULT1E1(3), UGT1A1(1), UGT1A5(3), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), WBSCR22(2)	8524209	83	36	83	31	19	30	3	19	12	0	0.408	1.000	1.000
435	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(4), AASDH(3), AASS(2), ACAT1(2), ACAT2(2), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), BBOX1(1), DLST(1), DOT1L(7), EHHADH(2), EHMT1(6), EHMT2(3), GCDH(3), HADHA(2), PLOD1(5), PLOD2(3), PLOD3(4), SDS(1), SHMT1(1), SHMT2(3), TMLHE(3)	6391636	84	36	83	36	21	32	2	16	13	0	0.569	1.000	1.000
436	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), ELK1(2), IKBKB(3), IRAK1(4), JUN(2), MAP2K3(1), MAP2K4(5), MAP2K6(1), MAP3K1(6), MAP3K14(2), MAP3K7(6), MAPK14(1), MAPK8(3), MYD88(1), NFKB1(5), PPARA(3), RELA(1), TIRAP(2), TLR10(3), TLR2(1), TLR3(2), TLR4(11), TLR6(1), TLR7(3), TLR9(10), TOLLIP(1), TRAF6(4)	6316676	85	36	83	29	25	19	5	24	12	0	0.394	1.000	1.000
437	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(15), MAP2(14), PPP1CA(1), PPP2CA(3), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAR2A(1), PRKAR2B(6), PRKCE(5)	3149481	52	35	52	19	9	20	0	17	6	0	0.653	1.000	1.000
438	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(2), CLOCK(2), CRY1(1), CRY2(1), DAZAP2(3), DNAJA1(2), EIF4G2(1), ETV6(2), G0S2(1), GFRA1(5), GSTM3(1), GSTP1(1), HSPA8(3), KLF9(1), NCKAP1(5), NR1D2(3), PER1(3), PER2(9), PPP1R3C(3), PPP2CB(2), PSMA4(3), PURA(1), SF3A3(2), SUMO3(1), TOB1(1), TUBB3(7), UCP3(1), UGP2(1), ZFR(7)	6299338	75	35	75	33	26	20	3	22	4	0	0.770	1.000	1.000
439	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(5), DIAPH1(3), FYN(5), GSN(5), ITGA1(3), ITGB1(4), MAP2K1(2), MAPK1(2), MAPK3(1), MYL2(1), MYLK(7), PIK3R1(5), PTK2(7), PXN(1), RAF1(5), ROCK1(7), SHC1(3), TLN1(11)	6091274	77	35	76	26	19	26	3	16	12	1	0.368	1.000	1.000
440	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(2), ATM(13), ATR(5), CCNA1(4), CCND1(1), CCNE1(3), CDC25A(2), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(3), GSK3B(2), HDAC1(2), RB1(7), SKP2(3), TFDP1(2), TGFB1(3), TGFB2(6), TGFB3(3)	5097712	68	35	66	29	17	23	2	17	8	1	0.792	1.000	1.000
441	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), ADRBK2(4), ARRB2(1), CALM1(1), CALM2(2), CALM3(1), CAMK2A(1), CAMK2G(4), CLCA1(2), CLCA2(4), CLCA4(4), CNGA3(6), CNGA4(9), CNGB1(5), GUCA1A(1), GUCA1C(1), PDC(1), PDE1C(2), PRKACA(1), PRKACB(2), PRKACG(3), PRKG1(6), PRKG2(6), PRKX(2)	5295593	70	35	68	29	24	19	3	17	7	0	0.565	1.000	1.000
442	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(6), ADCY3(1), ADCY9(5), ARF1(2), ARL4D(1), ATP6V0A1(4), ATP6V0A2(1), ATP6V0A4(4), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), GNAS(11), PLCG1(10), PLCG2(6), SEC61A1(1), SEC61B(1), SEC61G(1), TRIM23(2)	6400535	78	35	77	30	28	20	3	21	6	0	0.541	1.000	1.000
443	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(14), ACAT1(2), ACAT2(2), ACYP2(1), ADH5(1), AKR1B1(5), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH9A1(3), DLAT(3), DLD(2), GRHPR(2), HAGH(1), LDHB(1), LDHC(1), LDHD(1), MDH1(3), ME1(2), ME2(3), ME3(4), PC(5), PCK1(2), PDHA1(1), PDHA2(4), PDHB(2), PKLR(4), PKM2(2)	6378329	94	35	94	31	30	29	2	23	10	0	0.232	1.000	1.000
444	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(2), BAK1(2), BCL2(1), BID(1), BIRC2(2), BIRC3(3), CASP2(2), CASP3(1), CASP6(1), CASP7(2), CASP8(5), CASP9(1), FAS(2), JUN(2), MAP2K4(5), MAP3K1(6), MAP3K14(2), MAPK10(1), MDM2(3), NFKB1(5), PARP1(4), PRF1(1), RELA(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TNFSF10(2), TRAF1(2), TRAF2(2)	6330936	65	34	65	25	20	18	2	15	10	0	0.489	1.000	1.000
445	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(7), ELK1(2), GNAS(11), GNGT1(3), GRB2(1), IGF1R(10), ITGB1(4), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MKNK1(1), NGFR(4), PDGFRA(3), PPP2CA(3), PTPRR(2), RAF1(5), RPS6KA1(6), SHC1(3), SOS1(3), STAT3(6)	5713159	80	34	79	35	25	27	0	19	9	0	0.800	1.000	1.000
446	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(3), ACAA2(1), ACADM(1), ACADS(1), ACAT1(2), ACAT2(2), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(3), AOX1(2), AUH(5), BCAT1(1), BCAT2(1), BCKDHA(4), DBT(2), DLD(2), EHHADH(2), HADH(2), HADHA(2), HADHB(2), HIBADH(2), HMGCS1(1), HMGCS2(1), HSD17B4(1), IVD(1), MCCC1(2), MCCC2(1), MCEE(3), MUT(1), OXCT1(3), PCCA(7), PCCB(2)	7452575	80	34	76	27	20	23	1	17	18	1	0.418	1.000	1.000
447	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(1), ARSE(3), ASAH1(2), B4GALT6(1), CERK(3), DEGS1(1), DEGS2(2), ENPP7(2), GAL3ST1(4), GALC(4), GBA(4), GLB1(2), LCT(7), NEU2(2), NEU3(1), NEU4(1), PPAP2C(4), SGMS1(1), SMPD1(3), SMPD3(5), SMPD4(3), SPHK1(3), SPTLC2(2), UGT8(4)	6176481	66	34	66	32	32	23	0	8	3	0	0.696	1.000	1.000
448	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(2), CAPN2(2), CAPNS1(1), CAPNS2(1), EGF(4), EGFR(7), ITGA1(3), ITGB1(4), MAPK1(2), MAPK3(1), MYL2(1), MYLK(7), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), PTK2(7), PXN(1), TLN1(11)	5654960	68	34	66	32	25	18	3	15	7	0	0.728	1.000	1.000
449	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ARHGAP4(2), ARHGAP5(5), ARHGAP6(3), ARHGEF1(2), ARHGEF11(10), ARHGEF5(4), ARPC1A(3), ARPC4(1), BAIAP2(3), CFL1(1), DIAPH1(3), GSN(5), LIMK1(3), MYL2(1), MYLK(7), OPHN1(6), PIP5K1A(2), PPP1R12B(6), ROCK1(7), TLN1(11), VCL(2)	7875483	89	34	89	41	33	30	2	15	8	1	0.815	1.000	1.000
450	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(2), ARSB(3), FUCA1(1), FUCA2(2), GALNS(1), GBA(4), GLB1(2), GNS(3), GUSB(2), HEXA(1), HEXB(2), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(2), HYAL2(2), IDS(2), IDUA(1), LCT(7), MAN2B1(8), MAN2B2(8), MAN2C1(4), MANBA(2), NAGLU(1), NEU2(2), NEU3(1), NEU4(1), SPAM1(5)	5956106	76	33	75	32	27	29	1	12	7	0	0.620	1.000	1.000
451	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BAD(1), BRAF(5), CREB1(4), CREB3(2), CREB5(1), DUSP4(1), DUSP6(1), DUSP9(2), EEF2K(6), EIF4E(1), GRB2(1), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MKNK1(1), MOS(3), NFKB1(5), RAP1A(2), RPS6KA1(6), RPS6KA2(6), RPS6KA3(1), SHC1(3), SOS1(3), SOS2(3), TRAF3(2)	5107721	66	33	65	28	22	19	0	15	10	0	0.744	1.000	1.000
452	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(2), AKT2(2), AKT3(3), CISH(1), GRB2(1), IARS(6), IL13RA1(2), IL2RG(3), IL4R(1), INPP5D(1), JAK1(2), JAK2(8), JAK3(3), NR0B2(1), PI3(1), PPP1R13B(5), RPS6KB1(2), SERPINA4(2), SHC1(3), SOS1(3), SOS2(3), TYK2(4)	6012046	59	33	58	19	13	18	1	14	12	1	0.492	1.000	1.000
453	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(2), ABAT(3), ADSL(2), ADSS(3), AGXT(1), AGXT2(5), ASL(3), ASNS(3), CAD(5), CRAT(3), DARS(1), DDO(2), GAD1(3), GAD2(3), GOT1(1), GOT2(2), GPT2(2), NARS(3), PC(5)	4501590	52	32	51	24	23	14	0	14	1	0	0.760	1.000	1.000
454	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(1), CALM1(1), CALM2(2), CALM3(1), EGFR(7), ELK1(2), GNAQ(1), GRB2(1), JUN(2), MAP2K1(2), MAP2K2(1), MAP2K4(5), MAP3K1(6), MAPK1(2), MAPK3(1), MAPK8(3), MEF2B(3), MEF2C(2), MEF2D(5), PAK1(4), PTK2(7), PTK2B(5), RAF1(5), SHC1(3), SOS1(3)	5808684	76	32	76	28	22	22	5	16	11	0	0.425	1.000	1.000
455	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(3), ACTN2(11), ACTN3(1), BCAR1(4), CSK(2), CTNNA1(4), CTNNA2(11), CTNNB1(10), PTK2(7), PXN(1), VCL(2)	3290026	56	32	55	26	17	16	4	13	6	0	0.802	1.000	1.000
456	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(10), AKT1(2), ASAH1(2), GNAI1(1), GNGT1(3), ITGAV(3), ITGB3(3), MAPK1(2), MAPK3(1), PDGFA(1), PDGFRA(3), PIK3R1(5), PLCB1(10), PTK2(7), SMPD1(3), SPHK1(3)	4366105	59	32	59	28	17	23	4	5	10	0	0.759	1.000	1.000
457	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(2), ALDOC(2), DLAT(3), DLD(2), ENO1(2), ENO2(1), ENO3(2), FBP1(1), FBP2(3), GAPDH(1), GAPDHS(2), GCK(3), GOT1(1), GOT2(2), GPI(4), HK1(5), HK2(5), HK3(3), LDHAL6B(2), LDHB(1), LDHC(1), MDH1(3), PC(5), PCK1(2), PDHA1(1), PDHA2(4), PDHB(2), PDHX(2), PFKL(4), PFKM(2), PFKP(7), PGAM2(2), PGK1(1), PGK2(1), PKLR(4), PKM2(2), TNFAIP1(1), TPI1(2)	7321282	93	32	93	44	42	27	2	18	4	0	0.748	1.000	1.000
458	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(3), ACACA(14), ACACB(10), ACADM(1), ACAT1(2), ACAT2(2), ACSS1(6), ACSS2(3), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(3), EHHADH(2), HADHA(2), LDHAL6B(2), LDHB(1), LDHC(1), MCEE(3), MLYCD(3), MUT(1), PCCA(7), PCCB(2), SUCLA2(3), SUCLG1(1), SUCLG2(3)	6855104	92	32	88	30	27	24	2	20	19	0	0.312	1.000	1.000
459	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(4), ALAS1(1), ALAS2(4), BLVRA(2), COX10(1), COX15(3), CP(3), EARS2(1), EPRS(6), FECH(4), FTH1(1), FTMT(2), GUSB(2), HCCS(1), HMOX1(3), PPOX(2), UGT1A1(1), UGT1A5(3), UGT2A1(2), UGT2A3(3), UGT2B10(3), UGT2B11(1), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(2), UROD(1), UROS(3)	7127323	65	32	65	31	11	23	3	20	8	0	0.887	1.000	1.000
460	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(3), ACACA(14), ACADL(1), ACADM(1), ACADSB(3), ACAT1(2), ACAT2(2), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(3), EHHADH(2), HADHA(2), LDHB(1), LDHC(1), MCEE(3), MLYCD(3), MUT(1), PCCA(7), PCCB(2), SDS(1), SUCLA2(3), SUCLG1(1), SUCLG2(3)	5716483	83	32	79	28	25	28	0	15	15	0	0.355	1.000	1.000
461	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2G(4), DAG1(5), ITPKA(1), ITPKB(5), ITPR1(17), ITPR2(14), ITPR3(16), NFAT5(4), PDE6A(3), PDE6B(5), PDE6C(2), PDE6G(1), SLC6A13(1), TF(5)	6229824	84	32	84	31	28	25	7	11	12	1	0.326	1.000	1.000
462	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(13), ATR(5), BRCA1(7), BRCA2(14), CHEK1(1), CHEK2(5), FANCA(5), FANCC(2), FANCD2(8), FANCE(1), FANCG(1), HUS1(1), MRE11A(2), RAD1(1), RAD50(6), RAD51(1), RAD9A(1)	7517578	74	31	73	19	16	31	3	14	9	1	0.118	1.000	1.000
463	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ABAT(3), ACADS(1), ACAT1(2), ACAT2(2), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH5A1(2), ALDH9A1(3), EHHADH(2), GAD1(3), GAD2(3), HADHA(2), L2HGDH(1), OXCT1(3), PDHA1(1), PDHA2(4), PDHB(2), SDHB(3), SDS(1)	4454356	63	31	61	27	20	18	0	18	7	0	0.672	1.000	1.000
464	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	21	AKT1(2), EIF4A1(1), EIF4A2(3), EIF4E(1), EIF4EBP1(1), EIF4G1(8), EIF4G2(1), EIF4G3(4), GHR(3), IRS1(6), MAPK1(2), MAPK14(1), MAPK3(1), MKNK1(1), PABPC1(3), PDPK1(1), PIK3R1(5), PTEN(8), RPS6KB1(2)	4487437	54	31	54	21	12	18	3	11	10	0	0.721	1.000	1.000
465	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT4(3), CHST1(8), CHST2(7), CHST6(3), FUT8(2), ST3GAL1(2), ST3GAL2(4), ST3GAL4(3)	2152973	44	31	43	18	24	10	1	8	1	0	0.518	1.000	1.000
466	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(4), POLA2(2), POLD1(7), POLD3(1), POLE(12), POLE2(1), POLE3(1), POLE4(1), POLG(3), POLG2(3), POLH(2), POLK(1), POLL(1), POLM(3), POLQ(13), PRIM1(1), PRIM2(3), REV1(4), REV3L(16)	7088136	79	31	79	38	19	24	2	17	17	0	0.939	1.000	1.000
467	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(10), CAP1(1), CCNB1(1), CDC25C(2), GNAI1(1), GNAS(11), GNGT1(3), MAPK1(2), MAPK3(1), MYT1(9), PIN1(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), RPS6KA1(6)	3546144	62	31	62	29	22	21	0	13	6	0	0.802	1.000	1.000
468	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM2(2), CALM3(1), DLG4(3), GRIN1(2), GRIN2A(6), GRIN2B(8), GRIN2C(3), NOS1(15), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6)	4410926	58	31	58	23	20	20	1	10	7	0	0.516	1.000	1.000
469	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(4), DYRK1B(6), GLI2(6), GLI3(15), GSK3B(2), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), SMO(6), SUFU(2)	2856738	54	31	54	27	18	13	2	15	6	0	0.777	1.000	1.000
470	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(1), EGF(4), EGFR(7), GRB2(1), MAP2K1(2), MAPK1(2), MAPK3(1), PTPRB(10), RAF1(5), RASA1(9), SHC1(3), SOS1(3), SPRY1(2), SPRY3(3), SPRY4(3)	4336102	56	31	55	20	13	14	1	17	10	1	0.618	1.000	1.000
471	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	24	EIF2B1(3), EIF2B3(3), EIF2B4(5), EIF2B5(3), EIF2S1(1), EIF2S2(2), ELAVL1(3), FLT1(5), FLT4(6), HIF1A(2), KDR(4), NOS3(3), PIK3R1(5), PLCG1(10), PTK2(7), PXN(1), SHC1(3)	5486922	66	31	64	22	23	21	4	11	7	0	0.256	1.000	1.000
472	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM2(2), CALM3(1), EGR2(3), EGR3(1), GNAQ(1), MAP3K1(6), NFATC1(8), NFATC2(6), NFKB1(5), PLCG1(10), PPP3CA(3), PPP3CB(1), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), RELA(1), VIP(1), VIPR2(3)	4827640	66	31	65	27	26	22	1	12	5	0	0.511	1.000	1.000
473	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(5), B4GALT1(2), B4GALT2(5), GAA(2), GALE(1), GALK1(1), GALK2(2), GALT(1), GANC(4), GCK(3), GLB1(2), HK1(5), HK2(5), HK3(3), HSD3B7(3), LALBA(1), LCT(7), MGAM(6), PFKL(4), PFKM(2), PFKP(7), PGM1(2), PGM3(6), RDH11(1), RDH12(1), UGP2(1)	6694113	82	30	81	39	38	30	2	6	6	0	0.692	1.000	1.000
474	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLAT(3), DLD(2), DLST(1), FH(2), IDH3A(1), IDH3B(3), IDH3G(2), MDH1(3), OGDH(6), PC(5), PDHA1(1), PDHA2(4), PDHB(2), PDHX(2), PDK1(1), PDK3(2), SDHA(5), SDHB(3), SDHC(1), SUCLA2(3), SUCLG1(1), SUCLG2(3)	4894757	56	30	55	28	19	15	1	15	6	0	0.900	1.000	1.000
475	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(4), CALM1(1), CALM2(2), CALM3(1), GNAQ(1), GRB2(1), JUN(2), MAP2K1(2), MAP2K2(1), MAP2K3(1), MAP2K4(5), MAP3K1(6), MAPK1(2), MAPK14(1), MAPK3(1), MAPK8(3), PAK1(4), PLCG1(10), PTK2B(5), RAF1(5), SHC1(3), SOS1(3)	4905132	64	30	63	22	20	20	0	15	9	0	0.441	1.000	1.000
476	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(2), AKT2(2), AKT3(3), BAD(1), BCL2(1), GRB2(1), GSK3A(1), GSK3B(2), IL4R(1), IRS1(6), IRS2(3), JAK1(2), JAK3(3), MAP4K1(2), MAPK1(2), MAPK3(1), PDK1(1), PIK3CD(8), PIK3R1(5), PPP1R13B(5), RAF1(5), SHC1(3), SOCS1(1), SOS1(3), SOS2(3)	5930857	67	30	65	22	25	21	0	12	8	1	0.316	1.000	1.000
477	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(2), ATM(13), BRCA1(7), CDKN1A(1), CHEK1(1), CHEK2(5), JUN(2), MAPK8(3), MDM2(3), MRE11A(2), NFKB1(5), RAD50(6), RAD51(1), RBBP8(3), RELA(1), TP73(1)	5027061	56	29	55	15	11	16	3	15	10	1	0.300	1.000	1.000
478	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), ACO1(8), DLD(2), DLST(1), FH(2), IDH3A(1), IDH3B(3), IDH3G(2), MDH1(3), OGDH(6), OGDHL(3), PC(5), PCK1(2), PCK2(5), SDHA(5), SDHB(3), SDHC(1), SUCLA2(3), SUCLG1(1), SUCLG2(3)	5152016	61	29	59	24	25	17	2	10	7	0	0.486	1.000	1.000
479	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B4GALT5(3), C1GALT1C1(3), GALNT10(3), GALNT11(4), GALNT12(1), GALNT13(2), GALNT14(4), GALNT2(2), GALNT4(1), GALNT5(4), GALNT6(2), GALNT8(3), GALNT9(2), GALNTL1(2), GALNTL2(4), GALNTL4(5), GALNTL5(2), GCNT3(1), GCNT4(1), OGT(1), ST3GAL1(2), ST3GAL2(4), ST6GALNAC1(1)	5378450	57	29	57	31	22	16	1	15	3	0	0.962	1.000	1.000
480	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG7(4), BECN1(1), GABARAPL1(3), IFNA1(1), IFNA10(1), IFNA16(1), IFNA17(3), IFNA5(2), IFNA7(2), IFNA8(1), IFNG(2), PIK3C3(6), PIK3R4(7), PRKAA1(1), PRKAA2(2), ULK1(9), ULK2(4)	3664972	51	29	51	18	11	15	5	13	7	0	0.462	1.000	1.000
481	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	20	AKT1(2), EIF4A1(1), EIF4A2(3), EIF4B(2), EIF4E(1), EIF4EBP1(1), EIF4G1(8), EIF4G2(1), EIF4G3(4), MKNK1(1), PDPK1(1), PIK3R1(5), PPP2CA(3), PTEN(8), RPS6(1), RPS6KB1(2), TSC1(3), TSC2(3)	4412307	50	29	50	25	13	17	1	10	9	0	0.953	1.000	1.000
482	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(1), ACADL(1), ACADM(1), ACADS(1), ACADSB(3), ACAT1(2), ACAT2(2), ALDH1A1(3), ALDH1A2(4), ALDH1A3(5), ALDH1B1(3), ALDH2(1), ALDH3A1(3), ALDH3A2(4), ALDH6A1(1), ALDH9A1(3), AOX1(2), BCAT1(1), BCKDHA(4), EHHADH(2), HADHA(2), HADHB(2), HIBADH(2), IVD(1), MCCC1(2), MCCC2(1), MCEE(3), MUT(1), OXCT1(3), PCCA(7), PCCB(2), SDS(1)	6228597	74	29	71	29	15	28	0	15	15	1	0.660	1.000	1.000
483	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(2), CARS(2), DARS(1), EPRS(6), FARS2(5), GARS(1), HARS(3), IARS(6), KARS(2), LARS(2), LARS2(5), MARS(2), MARS2(1), NARS(3), QARS(4), RARS(2), SARS(2), TARS(4), WARS(3), WARS2(5), YARS(1)	5549238	62	28	62	21	18	24	2	16	2	0	0.396	1.000	1.000
484	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(10), AKT1(2), BAD(1), BCL2(1), CSF2RB(4), IGF1(2), IGF1R(10), IL3(1), IL3RA(4), KIT(6), KITLG(3), PIK3R1(5), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), YWHAH(1)	3411804	63	28	63	28	17	29	0	11	6	0	0.587	1.000	1.000
485	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(10), AKT1(2), CAMK2A(1), CAMK2G(4), CREB1(4), GNAS(11), GRB2(1), MAPK1(2), MAPK14(1), MAPK3(1), PIK3R1(5), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6), RPS6KA1(6), SOS1(3)	4642162	64	28	64	23	20	25	0	9	10	0	0.478	1.000	1.000
486	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(2), CD2(2), CD33(2), CD5(4), CD7(3), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL12B(1), IL13(1), IL3(1), ITGAX(5), TLR2(1), TLR4(11), TLR7(3), TLR9(10)	3222776	52	28	49	29	19	9	5	16	3	0	0.956	1.000	1.000
487	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(6), DDX20(3), ETS1(4), ETS2(1), HDAC2(2), HDAC5(4), JUN(2), NCOR2(13), RBL1(3), SIN3A(5), SIN3B(8)	4475723	51	28	51	23	17	10	1	20	3	0	0.805	1.000	1.000
488	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(5), B4GALT1(2), B4GALT2(5), FBP2(3), GAA(2), GALE(1), GALK1(1), GALK2(2), GALT(1), GANAB(3), GCK(3), GLB1(2), HK1(5), HK2(5), HK3(3), LALBA(1), LCT(7), MGAM(6), PFKM(2), PFKP(7), PGM1(2), PGM3(6)	5650923	74	28	73	34	35	23	2	6	8	0	0.687	1.000	1.000
489	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(2), CSF3(1), HLA-DRA(3), HLA-DRB1(1), IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL11(2), IL12B(1), IL13(1), IL3(1), IL8(1), LTA(2), PDGFA(1), TGFB1(3), TGFB2(6), TGFB3(3), TNF(1)	2312620	35	28	35	14	8	12	1	12	2	0	0.670	1.000	1.000
490	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(10), ARHGEF1(2), F2(3), F2R(1), GNA12(1), GNAI1(1), GNAQ(1), GNGT1(3), MAP3K7(6), PIK3R1(5), PLCB1(10), PPP1R12B(6), PTK2B(5), ROCK1(7)	4087098	61	28	61	29	17	21	1	12	10	0	0.900	1.000	1.000
491	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(1), ERCC3(3), GTF2B(1), GTF2E1(4), GTF2E2(1), GTF2F2(2), GTF2H1(1), ILK(1), MNAT1(2), POLR1A(5), POLR2A(8), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3B(3), POLR3D(1), POLR3E(1), POLR3K(1), TAF13(1), TAF5(2), TAF6(4), TAF7(4), TBP(1)	6068132	55	28	55	20	20	17	2	11	5	0	0.475	1.000	1.000
492	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(3), F2R(1), GNAI1(1), GNGT1(3), ITGA1(3), ITGB1(4), MAP2K1(2), MAPK1(2), MAPK3(1), PLA2G4A(3), PLCB1(10), PTGS1(5), PTK2(7), RAF1(5), SYK(3), TBXAS1(1)	4206567	54	28	53	21	15	16	4	10	9	0	0.593	1.000	1.000
493	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(10), GNAS(11), GNGT1(3), PPP2CA(3), PRKAA1(1), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKACB(2), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6)	2647346	49	27	49	19	17	17	1	7	7	0	0.608	1.000	1.000
494	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP2(3), ACPP(2), ACPT(1), ALPI(3), ALPL(3), ALPP(4), ALPPL2(4), CYP19A1(5), CYP1A1(1), CYP1A2(3), CYP2A13(4), CYP2A6(1), CYP2A7(2), CYP2B6(2), CYP2C18(3), CYP2C19(6), CYP2D6(3), CYP2E1(3), CYP2F1(1), CYP2J2(2), CYP3A4(1), CYP3A7(2), CYP4B1(1), CYP4F8(1), CYP51A1(2), PON1(1)	5052542	64	27	64	22	26	19	3	11	5	0	0.250	1.000	1.000
495	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(2), CHIA(2), CHIT1(2), CMAS(3), CTBS(2), CYB5R1(1), CYB5R3(1), GFPT1(2), GFPT2(2), GNE(3), GNPDA1(3), HEXA(1), HEXB(2), HK1(5), HK2(5), HK3(3), LHPP(2), MTMR1(3), MTMR2(3), MTMR6(3), NPL(1), PGM3(6), PHPT1(2), RENBP(2)	4950502	61	27	61	21	23	21	4	11	2	0	0.250	1.000	1.000
496	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(4), ACE2(5), AGT(1), AGTR1(1), AGTR2(1), ANPEP(2), CPA3(1), CTSG(2), ENPEP(8), LNPEP(8), MAS1(1), MME(4), NLN(6), REN(2), THOP1(5)	3657265	51	27	51	21	17	21	2	10	1	0	0.495	1.000	1.000
497	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(10), DAXX(3), PAX3(4), PML(3), RARA(1), RB1(7), SIRT1(3), SP100(7), TNF(1), TNFRSF1A(2), TNFRSF1B(1)	3129695	42	27	41	16	14	11	2	8	7	0	0.572	1.000	1.000
498	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(2), BCL2(1), EGFR(7), IGF1R(10), POLR2A(8), PPP2CA(3), RB1(7), TEP1(12), TERF1(1), TERT(2), TNKS(6), XRCC5(3)	4738126	62	27	61	30	19	25	2	11	5	0	0.729	1.000	1.000
499	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(5), ALDOB(2), ALDOC(2), FBP1(1), FBP2(3), FPGT(3), FUK(1), GMDS(1), GMPPA(3), HK1(5), HK2(5), HK3(3), HSD3B7(3), LHPP(2), MTMR1(3), MTMR2(3), MTMR6(3), PFKFB2(4), PFKFB3(2), PFKFB4(1), PFKL(4), PFKM(2), PFKP(7), PHPT1(2), PMM1(1), PMM2(1), RDH11(1), RDH12(1), TPI1(2), TSTA3(4)	6442939	80	26	80	25	35	30	2	9	4	0	0.0612	1.000	1.000
500	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CARM1(2), CBS(3), CTH(2), GGT1(3), LCMT1(1), LCMT2(6), MARS(2), MARS2(1), MAT1A(2), MAT2B(1), METTL6(1), PAPSS1(3), PAPSS2(2), PRMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(3), SCLY(1), SEPHS2(1), WBSCR22(2)	4308136	46	26	46	23	12	16	2	8	8	0	0.815	1.000	1.000
501	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), B4GALNT1(1), GLB1(2), HEXA(1), HEXB(2), LCT(7), SLC33A1(4), ST3GAL1(2), ST3GAL2(4), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC5(1), ST6GALNAC6(3), ST8SIA1(3), ST8SIA5(2)	2840174	39	26	39	17	15	12	1	9	2	0	0.615	1.000	1.000
502	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	BCL2(1), CREBBP(10), EP300(13), FYN(5), IL2RG(3), IL7R(3), JAK1(2), JAK3(3), NMI(1), PIK3R1(5), PTK2B(5), STAT5A(1), STAT5B(2)	4458513	54	26	53	22	11	17	1	11	13	1	0.797	1.000	1.000
503	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), B4GALT1(2), B4GALT2(5), B4GALT5(3), DPM1(1), FUT8(2), MAN1B1(2), MGAT1(2), MGAT2(2), MGAT3(5), MGAT4A(2), MGAT4B(1), MGAT5(5), RPN1(1), RPN2(3)	3444284	37	26	36	25	13	9	1	10	4	0	0.992	1.000	1.000
504	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	26	ANXA1(3), ANXA4(2), ANXA5(1), ANXA6(2), CYP11A1(2), EDN1(3), EDNRA(1), HSD11B2(2), PLA2G4A(3), PRL(1), PTGDR(4), PTGER2(2), PTGER4(1), PTGFR(3), PTGIS(5), PTGS1(5), PTGS2(2), TBXAS1(1)	3421233	43	26	43	18	7	15	4	12	5	0	0.723	1.000	1.000
505	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(3), ATP6V0A1(4), ATP6V0A4(4), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), SHMT1(1)	2607077	38	25	38	17	6	17	2	11	2	0	0.735	1.000	1.000
506	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(10), CREM(1), FHL5(1), FSHB(1), FSHR(12), GNAS(11), XPO1(3)	1655801	39	25	38	13	13	11	2	11	2	0	0.622	1.000	1.000
507	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(3), ATP6V0A1(4), ATP6V0A4(4), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), SHMT1(1)	2607077	38	25	38	17	6	17	2	11	2	0	0.735	1.000	1.000
508	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(3), ARSD(1), ARSE(3), ASAH1(2), GAL3ST1(4), GALC(4), GBA(4), GLB1(2), LCT(7), NEU2(2), NEU3(1), NEU4(1), PPAP2C(4), SMPD1(3), SPTLC2(2)	4178602	44	25	44	24	22	18	0	2	2	0	0.804	1.000	1.000
509	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(2), FUCA1(1), FUCA2(2), GLB1(2), HEXA(1), HEXB(2), LCT(7), MAN2B1(8), MAN2B2(8), MAN2C1(4), MANBA(2), NEU2(2), NEU3(1), NEU4(1)	3511757	43	25	43	19	19	12	0	6	6	0	0.719	1.000	1.000
510	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(2), BAD(1), BCL2(1), CBL(1), GRB2(1), IL2RA(1), IL2RG(3), IRS1(6), JAK1(2), JAK3(3), MAPK1(2), MAPK3(1), NMI(1), PIK3R1(5), PTPN6(3), RAF1(5), RPS6KB1(2), SHC1(3), SOCS1(1), SOCS3(3), SOS1(3), STAT5A(1), STAT5B(2), SYK(3)	5867062	56	25	55	26	15	20	0	11	9	1	0.877	1.000	1.000
511	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(4), ELK1(2), GRB2(1), IL6ST(2), JAK1(2), JAK2(8), JAK3(3), JUN(2), MAP2K1(2), MAPK3(1), PTPN11(4), RAF1(5), SHC1(3), SOS1(3), STAT3(6)	4130572	48	25	48	17	9	20	0	13	5	1	0.507	1.000	1.000
512	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(7), AP2A1(1), AP2M1(4), CALM1(1), CALM2(2), CALM3(1), DNM1(4), EPN1(2), PPP3CA(3), PPP3CB(1), SYNJ1(3), SYNJ2(9)	3742160	38	25	38	14	16	7	2	10	3	0	0.448	1.000	1.000
513	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(3), ATP6V0A1(4), ATP6V0A4(4), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), FDXR(2), SHMT1(1)	2772982	40	25	40	18	7	17	2	11	3	0	0.729	1.000	1.000
514	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(10), ADRB2(3), GNAS(11), PLCE1(8), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6)	2548832	45	25	45	20	14	17	0	9	5	0	0.741	1.000	1.000
515	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	15	AKT1(2), AKT2(2), AKT3(3), BPNT1(1), GRB2(1), ILK(1), MAPK1(2), MAPK3(1), PDK1(1), PIK3CD(8), PTEN(8), PTK2B(5), SHC1(3), SOS1(3)	3155010	41	25	40	16	14	14	0	7	6	0	0.687	1.000	1.000
516	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(3), APOA1(2), APOA4(1), APOC2(1), CETP(2), CYP7A1(3), HMGCR(4), LCAT(1), LDLR(4), LIPC(2), LPL(2), LRP1(18), SCARB1(3), SOAT1(3)	4736040	49	25	49	30	20	12	4	9	4	0	0.965	1.000	1.000
517	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(3), ATP6V0A1(4), ATP6V0A4(4), ATP6V0B(2), ATP6V0D1(3), ATP6V1A(3), ATP6V1B1(4), ATP6V1C1(1), ATP6V1C2(4), ATP6V1D(1), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(4), SHMT1(1)	2607077	38	25	38	17	6	17	2	11	2	0	0.735	1.000	1.000
518	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(4), CCNB1(1), CCND1(1), CCND3(2), CCNE1(3), CCNH(1), CDC25A(2), CDK2(2), CDK6(4), CDKN1A(1), CDKN2A(3), CDKN2D(1), RB1(7), RBL1(3), TFDP1(2)	2778965	37	24	36	19	11	12	1	11	2	0	0.855	1.000	1.000
519	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(6), EPHB1(13), FYN(5), ITGA1(3), ITGB1(4), L1CAM(2), LYN(2), RAP1B(3), SELP(2)	2734111	41	24	40	22	16	7	4	12	2	0	0.882	1.000	1.000
520	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(3), IL13(1), MAF(2), MAP2K3(1), MAPK14(1), NFATC1(8), NFATC2(6), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6)	2074756	35	24	35	17	12	15	0	7	1	0	0.554	1.000	1.000
521	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AMD1(2), BHMT(3), CBS(3), CTH(2), DNMT1(10), DNMT3A(3), DNMT3B(6), MARS(2), MARS2(1), MAT1A(2), MAT2B(1), MTR(9), SRM(1), TAT(1)	3578370	46	24	46	31	15	18	1	10	2	0	0.984	1.000	1.000
522	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(3), GALNS(1), GLB1(2), GNS(3), GUSB(2), HEXA(1), HEXB(2), HGSNAT(2), HPSE(3), HPSE2(2), HYAL1(2), HYAL2(2), IDS(2), IDUA(1), LCT(7), NAGLU(1), SPAM1(5)	3543115	41	24	40	19	11	19	1	8	2	0	0.737	1.000	1.000
523	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(5), POLR1C(2), POLR1D(1), POLR2A(8), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLR3A(10), POLR3B(3), POLR3G(1), POLR3K(1)	4071009	39	24	39	14	13	14	1	9	2	0	0.454	1.000	1.000
524	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(4), EPX(4), LPO(2), MPO(5), PRDX6(1), SHMT1(1), SHMT2(3), TPO(13)	2036723	34	24	34	12	11	6	1	10	6	0	0.488	1.000	1.000
525	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(5), ARHGEF1(2), GNA12(1), GNAQ(1), GNGT1(3), MYL2(1), MYLK(7), PLCB1(10), PPP1R12B(6), ROCK1(7)	3575651	43	24	43	20	12	12	0	11	7	1	0.883	1.000	1.000
526	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	AKT1(2), CCND1(1), CCNE1(3), CDK2(2), CDK6(4), CDKN1A(1), MAPK1(2), MAPK3(1), NFKB1(5), PAK1(4), PIK3R1(5), RAF1(5), RB1(7), RELA(1), TFDP1(2)	3127692	45	24	44	15	8	16	1	11	9	0	0.539	1.000	1.000
527	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), GBA3(1), LPO(2), MPO(5), PRDX6(1), TPO(13), TYR(3)	1667887	29	24	29	16	11	5	0	10	3	0	0.925	1.000	1.000
528	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(3), AKR1D1(1), ARSB(3), ARSD(1), ARSE(3), CYP11B1(2), CYP11B2(2), HSD11B2(2), HSD17B3(1), HSD3B1(1), HSD3B2(1), SRD5A1(2), SRD5A2(2), STS(2), SULT1E1(3), UGT1A1(1), UGT1A5(3), UGT2B15(1), UGT2B4(2)	4735151	36	23	36	16	11	15	0	5	5	0	0.631	1.000	1.000
529	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(4), EGFR(7), MAP2K1(2), MAP3K1(6), MAPK14(1), NCOR2(13), RARA(1), RXRA(2), THRA(2), THRB(3)	2973132	41	23	41	20	17	8	0	11	5	0	0.774	1.000	1.000
530	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), GBA(4), GBA3(1), LPO(2), MPO(5), PRDX6(1), TPO(13)	1453726	30	23	30	13	13	7	0	8	2	0	0.690	1.000	1.000
531	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(5), ICAM1(2), ITGA4(5), ITGAL(5), ITGAM(4), ITGB1(4), ITGB2(5), SELE(3), SELL(4), SELP(2)	2769771	39	23	38	22	14	7	1	10	7	0	0.935	1.000	1.000
532	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CALM2(2), CALM3(1), CAMK1(1), CAMK1G(2), CAMK2A(1), CAMK2G(4), CAMK4(4), HDAC5(4), MEF2B(3), MEF2C(2), MEF2D(5), PPARA(3), PPP3CA(3), PPP3CB(1), SLC2A4(1), YWHAH(1)	3501495	39	23	39	15	13	11	2	10	3	0	0.469	1.000	1.000
533	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(4), BLVRA(2), CP(3), EPRS(6), FECH(4), GUSB(2), HCCS(1), HMOX1(3), PPOX(2), UGT1A1(1), UGT1A5(3), UGT2B15(1), UGT2B4(2), UROD(1), UROS(3)	4739103	38	23	38	19	6	15	1	10	6	0	0.877	1.000	1.000
534	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(4), CD44(5), FCGR3A(1), IL1B(1), SELL(4), TGFB1(3), TGFB2(6), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(2), TNFSF8(1)	2292338	31	23	31	16	9	9	0	8	5	0	0.734	1.000	1.000
535	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(5), DNMT1(10), MTNR1A(2), MTNR1B(2), PTAFR(2), PTGDR(4), PTGER2(2), PTGER4(1), PTGFR(3), TBXA2R(6)	1918397	37	23	37	21	12	12	3	8	2	0	0.859	1.000	1.000
536	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(7), CHAT(1), COMT(3), DBH(1), DDC(3), GAD1(3), GAD2(3), HDC(2), MAOA(1), PAH(3), PNMT(3), SLC18A3(5), TH(1), TPH1(1)	2485527	38	22	38	17	16	10	1	10	1	0	0.620	1.000	1.000
537	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(2), ALDOC(2), FBP1(1), FBP2(3), GOT1(1), GOT2(2), GPT2(2), MDH1(3), ME1(2), ME2(3), ME3(4), PGK1(1), PKLR(4), PKM2(2), TPI1(2)	3114534	34	22	34	14	13	9	1	9	2	0	0.622	1.000	1.000
538	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(7), POLE(12), POLG(3), POLL(1), POLQ(13)	2884255	36	22	36	22	10	9	1	9	7	0	0.962	1.000	1.000
539	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(2), B3GNT5(1), B4GALT1(2), B4GALT2(5), B4GALT4(3), FUT1(1), FUT4(1), FUT7(1), FUT9(2), ST3GAL6(2), ST8SIA1(3)	2775393	26	22	25	14	9	8	1	7	1	0	0.871	1.000	1.000
540	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(2), ALDOC(2), FBP1(1), FBP2(3), GOT1(1), GOT2(2), GPT2(2), MDH1(3), ME1(2), ME3(4), PGK1(1), PGK2(1), PKLR(4), PKM2(2), TKTL1(4), TKTL2(4), TPI1(2)	3482436	40	22	40	19	15	12	2	10	1	0	0.767	1.000	1.000
541	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(2), C9orf95(1), CD38(1), ENPP1(1), ENPP3(2), NADK(2), NADSYN1(3), NMNAT1(1), NMNAT2(1), NMNAT3(1), NNMT(1), NNT(6), NT5C(1), NT5C1A(1), NT5C1B(4), NT5C2(5), NUDT12(1)	3719540	34	22	34	16	10	12	2	6	3	1	0.774	1.000	1.000
542	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	BHMT(3), CBS(3), CTH(2), DNMT1(10), DNMT3A(3), DNMT3B(6), MARS(2), MARS2(1), MAT1A(2), MAT2B(1), MTR(9)	3002861	42	22	42	27	15	15	1	9	2	0	0.968	1.000	1.000
543	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(2), AKT2(2), AKT3(3), CDKN1A(1), ELK1(2), GRB2(1), MAP2K1(2), MAP2K2(1), NGFR(4), NTRK1(3), PIK3CD(8), SHC1(3), SOS1(3)	2412380	35	22	34	14	13	13	0	7	2	0	0.565	1.000	1.000
544	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(2), IKBKB(3), JUN(2), LTA(2), MAP2K3(1), MAP2K4(5), MAP2K6(1), MAP3K1(6), MAP3K14(2), MAP4K2(3), MAPK14(1), MAPK8(3), NFKB1(5), RELA(1), TANK(2), TNF(1), TNFRSF1A(2), TRAF2(2)	4159826	44	22	44	18	12	13	1	11	7	0	0.660	1.000	1.000
545	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(10), ADRB2(3), CFTR(2), GNAS(11), PRKACB(2), PRKACG(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(6)	2260164	39	21	39	16	15	15	0	6	3	0	0.628	1.000	1.000
546	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(2), ALDOC(2), FBP1(1), FBP2(3), G6PD(2), GPI(4), H6PD(3), PFKL(4), PFKM(2), PFKP(7), PGD(1), PGLS(2), PGM1(2), PGM3(6), PRPS1(1), PRPS1L1(1), PRPS2(1), TALDO1(2), TKTL1(4), TKTL2(4)	4198252	54	21	54	25	16	23	3	9	3	0	0.605	1.000	1.000
547	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), BCAT2(1), IARS(6), IARS2(3), ILVBL(1), LARS(2), LARS2(5), PDHA1(1), PDHA2(4), PDHB(2), VARS(7), VARS2(4)	3221674	37	21	37	12	10	10	2	11	4	0	0.441	1.000	1.000
548	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(2), G6PD(2), GCLM(2), GGT1(3), GPX3(1), GPX4(1), GPX6(1), GPX7(2), GSR(4), GSS(1), GSTA1(2), GSTA2(1), GSTA4(1), GSTA5(1), GSTM3(1), GSTM4(1), GSTO2(2), GSTP1(1), GSTZ1(3), MGST1(1), MGST3(1), OPLAH(4), TXNDC12(1)	3764629	39	21	39	18	12	12	2	11	2	0	0.744	1.000	1.000
549	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(4), ELK1(2), GRB2(1), IL2RA(1), IL2RG(3), JAK1(2), JAK3(3), JUN(2), MAP2K1(2), MAPK3(1), MAPK8(3), RAF1(5), SHC1(3), SOS1(3), STAT5A(1), STAT5B(2), SYK(3)	4042673	41	21	40	16	8	16	0	11	5	1	0.673	1.000	1.000
550	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(8), ABCB11(4), ABCB4(9), ABCC1(3), ABCC3(6), GSTP1(1)	2483600	31	21	31	14	8	10	1	7	5	0	0.713	1.000	1.000
551	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(2), FUCA1(1), FUCA2(2), GLB1(2), HEXA(1), HEXB(2), LCT(7), MAN2C1(4), MANBA(2), NEU2(2), NEU3(1), NEU4(1)	2847692	27	21	27	15	11	7	0	4	5	0	0.921	1.000	1.000
552	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(2), CD3G(2), CD4(2), FYN(5), HLA-DRA(3), HLA-DRB1(1), PTPRC(14), ZAP70(2)	1561630	31	21	29	17	5	10	1	12	3	0	0.956	1.000	1.000
553	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	14	ABL1(2), CDKN2A(3), MDM2(3), PIK3R1(5), POLR1A(5), POLR1C(2), POLR1D(1), RB1(7), TBX2(3)	2979685	31	20	30	18	8	11	1	4	7	0	0.914	1.000	1.000
554	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(13), CDC25A(2), CDC25B(2), CDC25C(2), CHEK1(1), MYT1(9), YWHAH(1)	2393987	30	20	29	10	11	11	1	3	3	1	0.436	1.000	1.000
555	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP2(3), ACP6(2), ACPP(2), ACPT(1), ALPI(3), ALPL(3), ALPP(4), ALPPL2(4), CYP3A4(1), CYP3A43(3), CYP3A7(2), DHRS3(1), DHRS7(1), DHRSX(2), PON1(1), PON2(2)	3103023	35	20	35	17	12	13	1	3	6	0	0.721	1.000	1.000
556	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(1), RPL10L(4), RPL12(1), RPL13A(1), RPL14(1), RPL18A(1), RPL19(2), RPL23A(1), RPL3(2), RPL31(1), RPL34(1), RPL36A(1), RPL6(1), RPL8(2), RPL9(2), RPS10(1), RPS11(1), RPS13(1), RPS23(1), RPS3(1), RPS3A(1), RPS5(2), RPS6(1), RPSA(3)	3917473	34	20	34	14	9	15	1	5	4	0	0.689	1.000	1.000
557	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(4), GRB2(1), IL3(1), IL3RA(4), JAK2(8), MAP2K1(2), MAPK3(1), PTPN6(3), RAF1(5), SHC1(3), SOS1(3), STAT5A(1), STAT5B(2)	3059909	38	20	38	16	10	16	0	7	5	0	0.671	1.000	1.000
558	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(2), ALDOC(2), FBP1(1), FBP2(3), G6PD(2), GPI(4), H6PD(3), PFKM(2), PFKP(7), PGD(1), PGLS(2), PGM1(2), PGM3(6), PRPS1(1), PRPS1L1(1), PRPS2(1), TAL1(1), TALDO1(2)	3526651	43	20	43	21	14	16	2	8	3	0	0.682	1.000	1.000
559	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(2), BAD(1), CHRNG(3), MUSK(4), PIK3R1(5), PTK2(7), PTK2B(5), RAPSN(2), TERT(2), YWHAH(1)	2445280	32	19	32	17	9	9	3	5	6	0	0.896	1.000	1.000
560	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), CSF1R(6), EGF(4), EGFR(7), GRB2(1), MET(4), PDGFRA(3), SH3GLB1(1), SH3GLB2(3), SH3KBP1(5)	3358407	35	19	35	28	14	7	2	7	5	0	0.996	1.000	1.000
561	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(4), EGFR(7), ERBB3(16), NRG1(5)	1766190	32	19	29	12	9	8	0	13	2	0	0.641	1.000	1.000
562	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(2), ATM(13), BCL2(1), CCND1(1), CCNE1(3), CDK2(2), CDKN1A(1), MDM2(3), PCNA(2), RB1(7), TIMP3(2)	3004204	37	19	35	13	8	16	2	5	5	1	0.523	1.000	1.000
563	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(2), CDK5R1(1), DAB1(5), FYN(5), LRP8(2), RELN(17), VLDLR(2)	2428428	34	19	34	16	10	13	1	7	3	0	0.756	1.000	1.000
564	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(2), CD3G(2), CD4(2), ICAM1(2), ITGAL(5), ITGB2(5), PTPRC(14)	1952702	34	19	32	15	9	8	1	11	5	0	0.828	1.000	1.000
565	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(2), G6PD(2), GCLM(2), GGT1(3), GPX3(1), GPX4(1), GSS(1), GSTA1(2), GSTA2(1), GSTA4(1), GSTM3(1), GSTM4(1), GSTO2(2), GSTP1(1), GSTZ1(3), MGST1(1), MGST3(1), PGD(1)	3111978	27	18	27	15	9	9	1	7	1	0	0.843	1.000	1.000
566	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(3), GALNS(1), GLB1(2), GNS(3), GUSB(2), HEXA(1), HEXB(2), IDS(2), IDUA(1), LCT(7), NAGLU(1)	2476130	25	18	25	15	6	12	0	5	2	0	0.900	1.000	1.000
567	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(5), ICAM1(2), ITGA4(5), ITGAL(5), ITGB1(4), ITGB2(5), SELE(3), SELL(4)	2103768	33	18	32	16	12	7	1	7	6	0	0.724	1.000	1.000
568	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), ESR1(4), GREB1(9), HSPB1(1), MTA1(3), PDZK1(2), TUBA8(3)	1896919	23	18	23	12	8	8	1	2	4	0	0.760	1.000	1.000
569	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(5), ICAM1(2), ITGAL(5), ITGAM(4), ITGB2(5), SELE(3), SELL(4)	1811952	28	18	28	16	12	4	1	6	5	0	0.918	1.000	1.000
570	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(4), CCNE1(3), CDC34(1), CDK2(2), CUL1(8), RB1(7), SKP2(3), TFDP1(2)	1487297	30	18	29	12	5	11	1	10	3	0	0.613	1.000	1.000
571	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	DUSP1(1), IKBKAP(2), IKBKB(3), LTA(2), MAP3K1(6), MAP3K14(2), NFKB1(5), RELA(1), TANK(2), TNFAIP3(5), TNFRSF1B(1), TRAF1(2), TRAF2(2), TRAF3(2)	3891280	36	18	36	13	15	9	1	6	5	0	0.478	1.000	1.000
572	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDPS(3), HMGCR(4), LSS(3), MVD(2), MVK(4), NQO1(2), NQO2(2), SC5DL(1), SQLE(4), VKORC1(1)	1921701	28	17	28	11	12	8	0	6	2	0	0.555	1.000	1.000
573	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP51A1(2), DHCR24(2), DHCR7(2), EBP(1), FDPS(3), GGPS1(1), HMGCR(4), HSD17B7(1), LSS(3), MVD(2), MVK(4), NQO1(2), NSDHL(2), SC4MOL(2), SC5DL(1), SQLE(4), TM7SF2(1), VKORC1(1)	3349428	38	17	38	19	14	9	2	10	3	0	0.892	1.000	1.000
574	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(4), MBTPS1(5), MBTPS2(2), SCAP(6), SREBF1(2), SREBF2(5)	2036196	25	17	25	14	8	11	0	4	2	0	0.827	1.000	1.000
575	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(4), CCNA2(1), CCND1(1), CCNE1(3), CCNE2(1), CDK2(2), CDKN2A(3), E2F2(2), PRB1(2)	1506602	19	17	19	14	3	8	1	5	2	0	0.965	1.000	1.000
576	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(2), IL13RA2(5), IL4R(1), JAK1(2), JAK2(8), TYK2(4)	1813352	23	17	23	10	6	6	2	4	4	1	0.769	1.000	1.000
577	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(2), IL13RA2(5), IL4R(1), JAK1(2), JAK2(8), TYK2(4)	1813352	23	17	23	10	6	6	2	4	4	1	0.769	1.000	1.000
578	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR2(2), ARPC1A(3), ARPC4(1), NCK1(3), NCKAP1(5), NTRK1(3), PSMA7(3), WASF1(3), WASF2(2), WASF3(1), WASL(1)	2636308	28	16	28	22	12	9	1	3	3	0	0.987	1.000	1.000
579	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(2), DHCR7(2), FDPS(3), HMGCR(4), HMGCS1(1), LSS(3), MVD(2), MVK(4), NSDHL(2), SC4MOL(2), SC5DL(1), SQLE(4)	2289128	30	16	30	13	12	7	1	8	2	0	0.718	1.000	1.000
580	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(8), ABCG2(2), BCHE(3), CES1(6), CES2(4), CYP3A4(1), UGT1A1(1), UGT1A5(3)	3957881	31	16	31	18	4	14	2	6	5	0	0.919	1.000	1.000
581	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(4), AGT(1), AGTR1(1), AGTR2(1), BDKRB2(2), KNG1(4), NOS3(3), REN(2)	1704505	18	15	18	11	6	6	1	2	3	0	0.819	1.000	1.000
582	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(2), CDK5R1(1), EGR1(3), MAP2K1(2), MAP2K2(1), MAPK1(2), MAPK3(1), NGFR(4), RAF1(5)	1411144	21	15	21	12	8	7	0	5	1	0	0.853	1.000	1.000
583	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(5), FARSA(2), FARSB(1), GOT1(1), GOT2(2), PAH(3), TAT(1), YARS(1), YARS2(1)	1506844	17	15	17	10	7	4	0	6	0	0	0.933	1.000	1.000
584	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), GRB2(1), IL2RG(3), IL4R(1), IRS1(6), JAK1(2), JAK3(3), RPS6KB1(2), SHC1(3)	2560727	23	15	22	14	6	8	0	4	4	1	0.967	1.000	1.000
585	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(2), HDAC9(1), MEF2B(3), MEF2C(2), MEF2D(5), MYOD1(3), YWHAH(1)	1362412	18	15	18	11	8	4	2	3	1	0	0.871	1.000	1.000
586	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(2), CD38(1), ENPP1(1), ENPP3(2), NADSYN1(3), NMNAT1(1), NMNAT2(1), NNMT(1), NNT(6), NT5C(1)	2511644	19	15	19	12	2	6	2	6	2	1	0.968	1.000	1.000
587	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(3), CAPN1(2), CAPNS1(1), CAPNS2(1), CDK5(2), CDK5R1(1), GSK3B(2), MAPT(3), PPP2CA(3)	1607661	18	15	17	10	8	7	0	1	2	0	0.788	1.000	1.000
588	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR2A(8), POLR2B(4), POLR2C(1), POLR2F(1), POLR2I(1), POLR2K(1), POLRMT(9)	2320362	25	15	25	11	10	9	0	4	2	0	0.643	1.000	1.000
589	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(1), HLA-DRA(3), HLA-DRB1(1), IFNG(2), IFNGR1(2), IFNGR2(1), IL12B(1), IL12RB1(4), IL12RB2(4), IL18R1(2), IL2RA(1), IL4R(1)	2195559	23	15	23	11	7	4	2	7	3	0	0.735	1.000	1.000
590	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(3), DLL1(3), FURIN(1), NOTCH1(12), PSEN1(1)	1589085	20	14	20	15	8	6	1	3	2	0	0.934	1.000	1.000
591	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), NRF1(1), UBE2A(2), UBE2D3(1), UBE2E3(3), UBE2G2(1), UBE2H(1), UBE2I(1), UBE2J2(3), UBE2L3(1), UBE2L6(1), UBE3A(4)	1816230	20	14	20	11	6	7	1	3	3	0	0.790	1.000	1.000
592	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(2), ARPC1A(3), ARPC4(1), CDC42(1), PAK1(4), PDGFRA(3), PIK3R1(5), WASL(1)	1938906	20	13	20	13	4	9	1	1	5	0	0.954	1.000	1.000
593	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(2), EGF(4), EGFR(7), HGS(3), RAB5A(2), TF(5)	2231430	23	13	23	13	4	5	1	10	3	0	0.918	1.000	1.000
594	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(4), ADORA2B(1), ADORA3(2), LTB4R(1), P2RY1(4), P2RY6(3)	1026499	15	13	15	8	6	3	0	6	0	0	0.763	1.000	1.000
595	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(15), RANGAP1(4)	1458848	20	13	20	12	1	9	2	6	2	0	0.907	1.000	1.000
596	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(3), CTH(2), GGT1(3), MARS(2), MARS2(1), MAT1A(2), MAT2B(1), PAPSS1(3), PAPSS2(2), SCLY(1)	2136099	20	13	20	14	7	8	1	2	2	0	0.936	1.000	1.000
597	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(2), IFNG(2), IL10(1), IL12B(1), IL13(1), IL16(1), IL3(1), IL8(1), LTA(2), TNF(1)	1724539	14	12	14	11	3	4	1	6	0	0	0.966	1.000	1.000
598	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(8), GRHPR(2), HAO1(1), MDH1(3), MTHFD1(2), MTHFD1L(2), MTHFD2(1)	2211514	19	12	18	11	5	10	0	2	2	0	0.830	1.000	1.000
599	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(8), GRHPR(2), HAO1(1), MDH1(3), MTHFD1(2), MTHFD1L(2), MTHFD2(1)	2316213	19	12	18	11	5	10	0	2	2	0	0.827	1.000	1.000
600	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	PLCG1(10), PTK2B(5)	1165398	15	12	14	7	8	3	0	4	0	0	0.759	1.000	1.000
601	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), ADSS(3), IMPDH1(1), MTHFD2(1), POLD1(7), POLG(3), PRPS2(1), RRM1(3), SRM(1)	2152171	22	12	22	10	4	13	1	2	2	0	0.608	1.000	1.000
602	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(2), B3GALT2(5), B3GALT5(1), B3GNT5(1), FUT1(1), ST3GAL4(3)	1248240	13	11	13	7	7	2	0	4	0	0	0.850	1.000	1.000
603	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(2), BCL2(1), CASP3(1), CASP9(1), DAXX(3), FAS(2), HSPB1(1), MAPKAPK3(1), TNF(1)	1954967	14	11	14	12	7	4	0	2	1	0	0.970	1.000	1.000
604	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), GAD1(3), HDC(2), PNMT(3), TH(1), TPH1(1)	1042142	11	10	11	8	4	3	1	3	0	0	0.929	1.000	1.000
605	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), ACAT2(2), BDH1(1), HMGCS1(1), HMGCS2(1), OXCT1(3)	1249587	10	9	10	7	3	4	0	3	0	0	0.941	1.000	1.000
606	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(3), ALDH1A2(4), BCMO1(1), RDH5(2)	673563	10	9	10	11	3	2	0	4	1	0	0.997	1.000	1.000
607	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(4), AASDH(3), AASS(2), KARS(2)	1208101	11	8	11	7	2	7	1	1	0	0	0.881	1.000	1.000
608	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(3), PLCD1(1), TGM2(4)	863842	8	8	8	5	6	1	0	1	0	0	0.793	1.000	1.000
609	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR2(2), ARPC1A(3), ARPC4(1), CDC42(1), WASF1(3), WASL(1)	1406748	12	7	12	13	4	5	1	1	1	0	0.995	1.000	1.000
610	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(3), RAB27A(3), RAB5A(2), RAB6A(1)	744678	10	6	10	9	2	6	0	2	0	0	0.949	1.000	1.000
611	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), ACAT2(2), OXCT1(3)	584778	7	6	7	5	2	4	0	1	0	0	0.927	1.000	1.000
612	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(6)	349972	6	5	6	3	2	1	0	3	0	0	0.835	1.000	1.000
613	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1), GOT2(2), TAT(1)	453569	4	4	4	3	2	1	0	1	0	0	0.886	1.000	1.000
614	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(1)	312759	2	2	2	2	1	1	0	0	0	0	0.910	1.000	1.000
615	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(1)	882556	1	1	1	5	1	0	0	0	0	0	1.000	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		87928	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
