(primary solid tumor cohort)
This pipeline computes the correlation between significant copy number variation (cnv) genes and molecular subtypes.
Testing the association between copy number variation of 27 peak regions and 8 molecular subtypes across 470 patients, 52 significant findings detected with Q value < 0.25.
-
Amp Peak 1(Xq22.3) cnvs correlated to 'CN_CNMF'.
-
Del Peak 2(2p23.1) cnvs correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', and 'MIRSEQ_CHIERARCHICAL'.
-
Del Peak 3(2q35) cnvs correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', and 'MIRSEQ_CHIERARCHICAL'.
-
Del Peak 6(6q22.31) cnvs correlated to 'CN_CNMF'.
-
Del Peak 9(8p12) cnvs correlated to 'CN_CNMF'.
-
Del Peak 10(8q24.22) cnvs correlated to 'CN_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', and 'MIRSEQ_CHIERARCHICAL'.
-
Del Peak 11(9q21.13) cnvs correlated to 'CN_CNMF'.
-
Del Peak 12(10q21.2) cnvs correlated to 'CN_CNMF'.
-
Del Peak 13(10q23.31) cnvs correlated to 'CN_CNMF' and 'MRNASEQ_CHIERARCHICAL'.
-
Del Peak 14(11p15.1) cnvs correlated to 'CN_CNMF'.
-
Del Peak 15(13q12.3) cnvs correlated to 'METHLYATION_CNMF'.
-
Del Peak 17(15q25.3) cnvs correlated to 'CN_CNMF'.
-
Del Peak 21(18p11.21) cnvs correlated to 'CN_CNMF'.
-
Del Peak 22(18q22.2) cnvs correlated to 'CN_CNMF'.
-
Del Peak 23(19p13.2) cnvs correlated to 'METHLYATION_CNMF', 'MIRSEQ_CNMF', and 'MIRSEQ_CHIERARCHICAL'.
-
Del Peak 26(21q21.1) cnvs correlated to 'CN_CNMF'.
-
Del Peak 27(22q13.1) cnvs correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', and 'MIRSEQ_CHIERARCHICAL'.
-
Del Peak 28(22q13.2) cnvs correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', and 'MIRSEQ_CHIERARCHICAL'.
-
Del Peak 29(22q13.31) cnvs correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', and 'MIRSEQ_CHIERARCHICAL'.
-
Del Peak 30(22q13.32) cnvs correlated to 'CN_CNMF', 'METHLYATION_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', and 'MIRSEQ_CHIERARCHICAL'.
Molecular subtypes |
CN CNMF |
METHLYATION CNMF |
RPPA CNMF |
RPPA CHIERARCHICAL |
MRNASEQ CNMF |
MRNASEQ CHIERARCHICAL |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
||
nCNV (%) | nWild-Type | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | |
Del Peak 2(2p23 1) | 12 (3%) | 458 |
4.94e-10 (9.88e-08) |
2.89e-05 (0.00515) |
0.772 (1.00) |
0.0179 (1.00) |
1.83e-05 (0.00341) |
1.93e-05 (0.00356) |
1.19e-06 (0.000229) |
5.09e-07 (9.87e-05) |
Del Peak 3(2q35) | 11 (2%) | 459 |
1.04e-11 (2.1e-09) |
2.47e-05 (0.00442) |
0.562 (1.00) |
0.00287 (0.425) |
1.83e-05 (0.00341) |
1.93e-05 (0.00356) |
1.19e-06 (0.000229) |
5.09e-07 (9.87e-05) |
Del Peak 27(22q13 1) | 81 (17%) | 389 |
5.8e-86 (1.19e-83) |
0.000321 (0.0548) |
0.205 (1.00) |
0.0795 (1.00) |
3.11e-07 (6.12e-05) |
2e-05 (0.00365) |
0.00371 (0.545) |
0.00144 (0.228) |
Del Peak 28(22q13 2) | 81 (17%) | 389 |
5.8e-86 (1.19e-83) |
0.000321 (0.0548) |
0.205 (1.00) |
0.0795 (1.00) |
3.11e-07 (6.12e-05) |
2e-05 (0.00365) |
0.00371 (0.545) |
0.00144 (0.228) |
Del Peak 29(22q13 31) | 81 (17%) | 389 |
5.8e-86 (1.19e-83) |
0.000321 (0.0548) |
0.205 (1.00) |
0.0795 (1.00) |
3.11e-07 (6.12e-05) |
2e-05 (0.00365) |
0.00371 (0.545) |
0.00144 (0.228) |
Del Peak 30(22q13 32) | 82 (17%) | 388 |
4.47e-84 (9.08e-82) |
0.000162 (0.0282) |
0.205 (1.00) |
0.0795 (1.00) |
1.64e-07 (3.25e-05) |
1.17e-05 (0.00222) |
0.00209 (0.322) |
0.000846 (0.139) |
Del Peak 10(8q24 22) | 7 (1%) | 463 |
5.43e-05 (0.00962) |
0.00247 (0.373) |
0.837 (1.00) |
0.0549 (1.00) |
0.00213 (0.324) |
0.00122 (0.196) |
0.000185 (0.0319) |
0.000108 (0.019) |
Del Peak 23(19p13 2) | 6 (1%) | 464 |
0.00498 (0.707) |
0.00102 (0.165) |
0.682 (1.00) |
0.256 (1.00) |
0.00664 (0.922) |
0.00259 (0.387) |
0.000641 (0.106) |
0.000407 (0.0684) |
Del Peak 13(10q23 31) | 11 (2%) | 459 |
6.4e-05 (0.0113) |
0.0184 (1.00) |
0.0336 (1.00) |
0.0641 (1.00) |
0.00424 (0.611) |
0.00115 (0.187) |
0.0315 (1.00) |
0.0136 (1.00) |
Amp Peak 1(Xq22 3) | 16 (3%) | 454 |
2.56e-06 (0.000486) |
0.461 (1.00) |
0.856 (1.00) |
0.129 (1.00) |
0.0422 (1.00) |
0.0361 (1.00) |
0.0704 (1.00) |
0.0468 (1.00) |
Del Peak 6(6q22 31) | 6 (1%) | 464 |
0.000427 (0.0712) |
0.00547 (0.772) |
0.0379 (1.00) |
0.798 (1.00) |
0.0173 (1.00) |
0.00933 (1.00) |
0.00877 (1.00) |
0.00798 (1.00) |
Del Peak 9(8p12) | 4 (1%) | 466 |
2.31e-05 (0.00416) |
0.0474 (1.00) |
0.0371 (1.00) |
0.0346 (1.00) |
0.00761 (1.00) |
0.00564 (0.789) |
||
Del Peak 11(9q21 13) | 22 (5%) | 448 |
4.31e-14 (8.7e-12) |
0.155 (1.00) |
0.182 (1.00) |
0.0136 (1.00) |
0.245 (1.00) |
0.788 (1.00) |
0.0282 (1.00) |
0.0542 (1.00) |
Del Peak 12(10q21 2) | 11 (2%) | 459 |
0.000788 (0.13) |
0.0668 (1.00) |
0.162 (1.00) |
1 (1.00) |
0.0513 (1.00) |
0.148 (1.00) |
0.373 (1.00) |
0.609 (1.00) |
Del Peak 14(11p15 1) | 6 (1%) | 464 |
9.28e-08 (1.85e-05) |
0.0202 (1.00) |
0.499 (1.00) |
1 (1.00) |
0.0495 (1.00) |
0.166 (1.00) |
0.0256 (1.00) |
0.0361 (1.00) |
Del Peak 15(13q12 3) | 15 (3%) | 455 |
0.0258 (1.00) |
0.00123 (0.197) |
0.388 (1.00) |
0.44 (1.00) |
0.00963 (1.00) |
0.0448 (1.00) |
0.0541 (1.00) |
0.0258 (1.00) |
Del Peak 17(15q25 3) | 7 (1%) | 463 |
0.00134 (0.213) |
0.032 (1.00) |
0.444 (1.00) |
0.0817 (1.00) |
0.0841 (1.00) |
0.0672 (1.00) |
0.0046 (0.658) |
0.00247 (0.373) |
Del Peak 21(18p11 21) | 4 (1%) | 466 |
0.000241 (0.0414) |
0.191 (1.00) |
1 (1.00) |
0.369 (1.00) |
0.242 (1.00) |
0.0893 (1.00) |
0.111 (1.00) |
0.0414 (1.00) |
Del Peak 22(18q22 2) | 5 (1%) | 465 |
0.00151 (0.233) |
0.0616 (1.00) |
1 (1.00) |
0.256 (1.00) |
0.12 (1.00) |
0.0427 (1.00) |
0.0395 (1.00) |
0.0134 (1.00) |
Del Peak 26(21q21 1) | 8 (2%) | 462 |
1.29e-05 (0.00242) |
0.172 (1.00) |
0.147 (1.00) |
0.206 (1.00) |
0.289 (1.00) |
0.459 (1.00) |
0.0516 (1.00) |
0.0866 (1.00) |
Del Peak 4(5p15 2) | 3 (1%) | 467 |
0.261 (1.00) |
0.728 (1.00) |
||||||
Del Peak 8(7q34) | 4 (1%) | 466 |
0.646 (1.00) |
0.635 (1.00) |
0.747 (1.00) |
0.589 (1.00) |
1 (1.00) |
1 (1.00) |
||
Del Peak 16(13q14 3) | 18 (4%) | 452 |
0.00717 (0.989) |
0.0318 (1.00) |
0.0908 (1.00) |
1 (1.00) |
0.0103 (1.00) |
0.0249 (1.00) |
0.0279 (1.00) |
0.021 (1.00) |
Del Peak 19(16q23 3) | 6 (1%) | 464 |
0.0518 (1.00) |
0.126 (1.00) |
0.444 (1.00) |
0.103 (1.00) |
0.127 (1.00) |
0.111 (1.00) |
0.194 (1.00) |
0.292 (1.00) |
Del Peak 20(17p13 1) | 8 (2%) | 462 |
0.0021 (0.322) |
0.884 (1.00) |
1 (1.00) |
1 (1.00) |
0.71 (1.00) |
0.642 (1.00) |
0.294 (1.00) |
0.308 (1.00) |
Del Peak 31(Xq22 1) | 6 (1%) | 464 |
0.0793 (1.00) |
0.437 (1.00) |
0.0993 (1.00) |
0.12 (1.00) |
0.671 (1.00) |
0.861 (1.00) |
0.522 (1.00) |
0.386 (1.00) |
Del Peak 32(Xq22 3) | 4 (1%) | 466 |
0.0568 (1.00) |
0.0474 (1.00) |
0.281 (1.00) |
0.369 (1.00) |
0.129 (1.00) |
0.4 (1.00) |
0.111 (1.00) |
0.0414 (1.00) |
P value = 2.56e-06 (Fisher's exact test), Q value = 0.00049
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 34 | 363 | 73 |
AMP PEAK 1(XQ22.3) MUTATED | 8 | 8 | 0 |
AMP PEAK 1(XQ22.3) WILD-TYPE | 26 | 355 | 73 |
P value = 4.94e-10 (Fisher's exact test), Q value = 9.9e-08
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 34 | 363 | 73 |
DEL PEAK 2(2P23.1) MUTATED | 9 | 1 | 2 |
DEL PEAK 2(2P23.1) WILD-TYPE | 25 | 362 | 71 |
P value = 2.89e-05 (Fisher's exact test), Q value = 0.0052
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 140 | 71 | 259 |
DEL PEAK 2(2P23.1) MUTATED | 10 | 2 | 0 |
DEL PEAK 2(2P23.1) WILD-TYPE | 130 | 69 | 259 |
P value = 1.83e-05 (Fisher's exact test), Q value = 0.0034
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 130 | 50 | 89 | 138 |
DEL PEAK 2(2P23.1) MUTATED | 11 | 0 | 0 | 0 |
DEL PEAK 2(2P23.1) WILD-TYPE | 119 | 50 | 89 | 138 |
P value = 1.93e-05 (Fisher's exact test), Q value = 0.0036
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 142 | 191 | 74 |
DEL PEAK 2(2P23.1) MUTATED | 11 | 0 | 0 |
DEL PEAK 2(2P23.1) WILD-TYPE | 131 | 191 | 74 |
P value = 1.19e-06 (Fisher's exact test), Q value = 0.00023
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 126 | 153 | 144 |
DEL PEAK 2(2P23.1) MUTATED | 11 | 0 | 0 |
DEL PEAK 2(2P23.1) WILD-TYPE | 115 | 153 | 144 |
P value = 5.09e-07 (Fisher's exact test), Q value = 9.9e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 173 | 133 | 117 |
DEL PEAK 2(2P23.1) MUTATED | 0 | 0 | 11 |
DEL PEAK 2(2P23.1) WILD-TYPE | 173 | 133 | 106 |
P value = 1.04e-11 (Fisher's exact test), Q value = 2.1e-09
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 34 | 363 | 73 |
DEL PEAK 3(2Q35) MUTATED | 10 | 1 | 0 |
DEL PEAK 3(2Q35) WILD-TYPE | 24 | 362 | 73 |
P value = 2.47e-05 (Fisher's exact test), Q value = 0.0044
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 140 | 71 | 259 |
DEL PEAK 3(2Q35) MUTATED | 10 | 1 | 0 |
DEL PEAK 3(2Q35) WILD-TYPE | 130 | 70 | 259 |
P value = 1.83e-05 (Fisher's exact test), Q value = 0.0034
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 130 | 50 | 89 | 138 |
DEL PEAK 3(2Q35) MUTATED | 11 | 0 | 0 | 0 |
DEL PEAK 3(2Q35) WILD-TYPE | 119 | 50 | 89 | 138 |
P value = 1.93e-05 (Fisher's exact test), Q value = 0.0036
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 142 | 191 | 74 |
DEL PEAK 3(2Q35) MUTATED | 11 | 0 | 0 |
DEL PEAK 3(2Q35) WILD-TYPE | 131 | 191 | 74 |
P value = 1.19e-06 (Fisher's exact test), Q value = 0.00023
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 126 | 153 | 144 |
DEL PEAK 3(2Q35) MUTATED | 11 | 0 | 0 |
DEL PEAK 3(2Q35) WILD-TYPE | 115 | 153 | 144 |
P value = 5.09e-07 (Fisher's exact test), Q value = 9.9e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 173 | 133 | 117 |
DEL PEAK 3(2Q35) MUTATED | 0 | 0 | 11 |
DEL PEAK 3(2Q35) WILD-TYPE | 173 | 133 | 106 |
P value = 0.000427 (Fisher's exact test), Q value = 0.071
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 34 | 363 | 73 |
DEL PEAK 6(6Q22.31) MUTATED | 4 | 2 | 0 |
DEL PEAK 6(6Q22.31) WILD-TYPE | 30 | 361 | 73 |
P value = 2.31e-05 (Fisher's exact test), Q value = 0.0042
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 34 | 363 | 73 |
DEL PEAK 9(8P12) MUTATED | 4 | 0 | 0 |
DEL PEAK 9(8P12) WILD-TYPE | 30 | 363 | 73 |
P value = 5.43e-05 (Fisher's exact test), Q value = 0.0096
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 34 | 363 | 73 |
DEL PEAK 10(8Q24.22) MUTATED | 5 | 2 | 0 |
DEL PEAK 10(8Q24.22) WILD-TYPE | 29 | 361 | 73 |
P value = 0.00122 (Fisher's exact test), Q value = 0.2
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 142 | 191 | 74 |
DEL PEAK 10(8Q24.22) MUTATED | 7 | 0 | 0 |
DEL PEAK 10(8Q24.22) WILD-TYPE | 135 | 191 | 74 |
P value = 0.000185 (Fisher's exact test), Q value = 0.032
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 126 | 153 | 144 |
DEL PEAK 10(8Q24.22) MUTATED | 7 | 0 | 0 |
DEL PEAK 10(8Q24.22) WILD-TYPE | 119 | 153 | 144 |
P value = 0.000108 (Fisher's exact test), Q value = 0.019
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 173 | 133 | 117 |
DEL PEAK 10(8Q24.22) MUTATED | 0 | 0 | 7 |
DEL PEAK 10(8Q24.22) WILD-TYPE | 173 | 133 | 110 |
P value = 4.31e-14 (Fisher's exact test), Q value = 8.7e-12
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 34 | 363 | 73 |
DEL PEAK 11(9Q21.13) MUTATED | 15 | 7 | 0 |
DEL PEAK 11(9Q21.13) WILD-TYPE | 19 | 356 | 73 |
P value = 0.000788 (Fisher's exact test), Q value = 0.13
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 34 | 363 | 73 |
DEL PEAK 12(10Q21.2) MUTATED | 5 | 6 | 0 |
DEL PEAK 12(10Q21.2) WILD-TYPE | 29 | 357 | 73 |
P value = 6.4e-05 (Fisher's exact test), Q value = 0.011
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 34 | 363 | 73 |
DEL PEAK 13(10Q23.31) MUTATED | 6 | 5 | 0 |
DEL PEAK 13(10Q23.31) WILD-TYPE | 28 | 358 | 73 |
P value = 0.00115 (Fisher's exact test), Q value = 0.19
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 142 | 191 | 74 |
DEL PEAK 13(10Q23.31) MUTATED | 8 | 0 | 2 |
DEL PEAK 13(10Q23.31) WILD-TYPE | 134 | 191 | 72 |
P value = 9.28e-08 (Fisher's exact test), Q value = 1.8e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 34 | 363 | 73 |
DEL PEAK 14(11P15.1) MUTATED | 6 | 0 | 0 |
DEL PEAK 14(11P15.1) WILD-TYPE | 28 | 363 | 73 |
P value = 0.00123 (Fisher's exact test), Q value = 0.2
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 140 | 71 | 259 |
DEL PEAK 15(13Q12.3) MUTATED | 10 | 3 | 2 |
DEL PEAK 15(13Q12.3) WILD-TYPE | 130 | 68 | 257 |
P value = 0.00134 (Fisher's exact test), Q value = 0.21
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 34 | 363 | 73 |
DEL PEAK 17(15Q25.3) MUTATED | 4 | 3 | 0 |
DEL PEAK 17(15Q25.3) WILD-TYPE | 30 | 360 | 73 |
P value = 0.000241 (Fisher's exact test), Q value = 0.041
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 34 | 363 | 73 |
DEL PEAK 21(18P11.21) MUTATED | 3 | 0 | 1 |
DEL PEAK 21(18P11.21) WILD-TYPE | 31 | 363 | 72 |
P value = 0.00151 (Fisher's exact test), Q value = 0.23
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 34 | 363 | 73 |
DEL PEAK 22(18Q22.2) MUTATED | 3 | 1 | 1 |
DEL PEAK 22(18Q22.2) WILD-TYPE | 31 | 362 | 72 |
P value = 0.00102 (Fisher's exact test), Q value = 0.17
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 140 | 71 | 259 |
DEL PEAK 23(19P13.2) MUTATED | 6 | 0 | 0 |
DEL PEAK 23(19P13.2) WILD-TYPE | 134 | 71 | 259 |
P value = 0.000641 (Fisher's exact test), Q value = 0.11
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 126 | 153 | 144 |
DEL PEAK 23(19P13.2) MUTATED | 6 | 0 | 0 |
DEL PEAK 23(19P13.2) WILD-TYPE | 120 | 153 | 144 |
P value = 0.000407 (Fisher's exact test), Q value = 0.068
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 173 | 133 | 117 |
DEL PEAK 23(19P13.2) MUTATED | 0 | 0 | 6 |
DEL PEAK 23(19P13.2) WILD-TYPE | 173 | 133 | 111 |
P value = 1.29e-05 (Fisher's exact test), Q value = 0.0024
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 34 | 363 | 73 |
DEL PEAK 26(21Q21.1) MUTATED | 5 | 1 | 2 |
DEL PEAK 26(21Q21.1) WILD-TYPE | 29 | 362 | 71 |
P value = 5.8e-86 (Fisher's exact test), Q value = 1.2e-83
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 34 | 363 | 73 |
DEL PEAK 27(22Q13.1) MUTATED | 8 | 0 | 73 |
DEL PEAK 27(22Q13.1) WILD-TYPE | 26 | 363 | 0 |
P value = 0.000321 (Fisher's exact test), Q value = 0.055
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 140 | 71 | 259 |
DEL PEAK 27(22Q13.1) MUTATED | 39 | 6 | 36 |
DEL PEAK 27(22Q13.1) WILD-TYPE | 101 | 65 | 223 |
P value = 3.11e-07 (Fisher's exact test), Q value = 6.1e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 130 | 50 | 89 | 138 |
DEL PEAK 27(22Q13.1) MUTATED | 36 | 4 | 21 | 7 |
DEL PEAK 27(22Q13.1) WILD-TYPE | 94 | 46 | 68 | 131 |
P value = 2e-05 (Fisher's exact test), Q value = 0.0037
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 142 | 191 | 74 |
DEL PEAK 27(22Q13.1) MUTATED | 36 | 15 | 17 |
DEL PEAK 27(22Q13.1) WILD-TYPE | 106 | 176 | 57 |
P value = 0.00144 (Fisher's exact test), Q value = 0.23
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 173 | 133 | 117 |
DEL PEAK 27(22Q13.1) MUTATED | 21 | 19 | 33 |
DEL PEAK 27(22Q13.1) WILD-TYPE | 152 | 114 | 84 |
P value = 5.8e-86 (Fisher's exact test), Q value = 1.2e-83
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 34 | 363 | 73 |
DEL PEAK 28(22Q13.2) MUTATED | 8 | 0 | 73 |
DEL PEAK 28(22Q13.2) WILD-TYPE | 26 | 363 | 0 |
P value = 0.000321 (Fisher's exact test), Q value = 0.055
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 140 | 71 | 259 |
DEL PEAK 28(22Q13.2) MUTATED | 39 | 6 | 36 |
DEL PEAK 28(22Q13.2) WILD-TYPE | 101 | 65 | 223 |
P value = 3.11e-07 (Fisher's exact test), Q value = 6.1e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 130 | 50 | 89 | 138 |
DEL PEAK 28(22Q13.2) MUTATED | 36 | 4 | 21 | 7 |
DEL PEAK 28(22Q13.2) WILD-TYPE | 94 | 46 | 68 | 131 |
P value = 2e-05 (Fisher's exact test), Q value = 0.0037
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 142 | 191 | 74 |
DEL PEAK 28(22Q13.2) MUTATED | 36 | 15 | 17 |
DEL PEAK 28(22Q13.2) WILD-TYPE | 106 | 176 | 57 |
P value = 0.00144 (Fisher's exact test), Q value = 0.23
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 173 | 133 | 117 |
DEL PEAK 28(22Q13.2) MUTATED | 21 | 19 | 33 |
DEL PEAK 28(22Q13.2) WILD-TYPE | 152 | 114 | 84 |
P value = 5.8e-86 (Fisher's exact test), Q value = 1.2e-83
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 34 | 363 | 73 |
DEL PEAK 29(22Q13.31) MUTATED | 8 | 0 | 73 |
DEL PEAK 29(22Q13.31) WILD-TYPE | 26 | 363 | 0 |
P value = 0.000321 (Fisher's exact test), Q value = 0.055
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 140 | 71 | 259 |
DEL PEAK 29(22Q13.31) MUTATED | 39 | 6 | 36 |
DEL PEAK 29(22Q13.31) WILD-TYPE | 101 | 65 | 223 |
P value = 3.11e-07 (Fisher's exact test), Q value = 6.1e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 130 | 50 | 89 | 138 |
DEL PEAK 29(22Q13.31) MUTATED | 36 | 4 | 21 | 7 |
DEL PEAK 29(22Q13.31) WILD-TYPE | 94 | 46 | 68 | 131 |
P value = 2e-05 (Fisher's exact test), Q value = 0.0037
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 142 | 191 | 74 |
DEL PEAK 29(22Q13.31) MUTATED | 36 | 15 | 17 |
DEL PEAK 29(22Q13.31) WILD-TYPE | 106 | 176 | 57 |
P value = 0.00144 (Fisher's exact test), Q value = 0.23
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 173 | 133 | 117 |
DEL PEAK 29(22Q13.31) MUTATED | 21 | 19 | 33 |
DEL PEAK 29(22Q13.31) WILD-TYPE | 152 | 114 | 84 |
P value = 4.47e-84 (Fisher's exact test), Q value = 9.1e-82
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 34 | 363 | 73 |
DEL PEAK 30(22Q13.32) MUTATED | 8 | 1 | 73 |
DEL PEAK 30(22Q13.32) WILD-TYPE | 26 | 362 | 0 |
P value = 0.000162 (Fisher's exact test), Q value = 0.028
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 140 | 71 | 259 |
DEL PEAK 30(22Q13.32) MUTATED | 40 | 6 | 36 |
DEL PEAK 30(22Q13.32) WILD-TYPE | 100 | 65 | 223 |
P value = 1.64e-07 (Fisher's exact test), Q value = 3.3e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 |
---|---|---|---|---|
ALL | 130 | 50 | 89 | 138 |
DEL PEAK 30(22Q13.32) MUTATED | 37 | 4 | 21 | 7 |
DEL PEAK 30(22Q13.32) WILD-TYPE | 93 | 46 | 68 | 131 |
P value = 1.17e-05 (Fisher's exact test), Q value = 0.0022
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 142 | 191 | 74 |
DEL PEAK 30(22Q13.32) MUTATED | 37 | 15 | 17 |
DEL PEAK 30(22Q13.32) WILD-TYPE | 105 | 176 | 57 |
P value = 0.000846 (Fisher's exact test), Q value = 0.14
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 173 | 133 | 117 |
DEL PEAK 30(22Q13.32) MUTATED | 21 | 19 | 34 |
DEL PEAK 30(22Q13.32) WILD-TYPE | 152 | 114 | 83 |
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Copy number data file = All Lesions File (all_lesions.conf_##.txt, where ## is the confidence level). The all lesions file is from GISTIC pipeline and summarizes the results from the GISTIC run. It contains data about the significant regions of amplification and deletion as well as which samples are amplified or deleted in each of these regions. The identified regions are listed down the first column, and the samples are listed across the first row, starting in column 10.
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Molecular subtype file = THCA-TP.transferedmergedcluster.txt
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Number of patients = 470
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Number of copy number variation regions = 27
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Number of molecular subtypes = 8
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Exclude regions that fewer than K tumors have alterations, K = 3
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.