Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.121 0.269 -9999.0 0.0 -0.707 29.0 29.0 IHH -0.223 0.388 -9999.0 0.0 -0.872 107.0 107.0 SHH Np/Cholesterol/GAS1 -0.112 0.216 -9999.0 0.0 -0.54 82.0 82.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.111 0.214 0.536 82.0 -9999.0 0.0 82.0 SMO/beta Arrestin2 -0.106 0.252 -9999.0 0.0 -0.501 109.0 109.0 SMO -0.118 0.265 -9999.0 0.0 -0.533 109.0 109.0 AKT1 -0.029 0.12 -9999.0 0.0 -0.33 1.0 1.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.004 0.12 -9999.0 0.0 -0.851 8.0 8.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.116 0.261 -9999.0 0.0 -0.525 109.0 109.0 STIL -0.087 0.205 -9999.0 0.0 -0.593 16.0 16.0 DHH N/PTCH2 -0.111 0.249 -9999.0 0.0 -0.665 68.0 68.0 DHH N/PTCH1 -0.111 0.238 -9999.0 0.0 -0.475 112.0 112.0 PIK3CA 0.011 0.043 -9999.0 0.0 -0.851 1.0 1.0 DHH 0.007 0.074 -9999.0 0.0 -0.851 3.0 3.0 PTHLH -0.17 0.381 -9999.0 0.0 -1.217 29.0 29.0 determination of left/right symmetry -0.116 0.261 -9999.0 0.0 -0.525 109.0 109.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.167 0.373 -9999.0 0.0 -1.187 29.0 29.0 IHH N/Hhip -0.408 0.416 -9999.0 0.0 -0.767 221.0 221.0 DHH N/Hhip -0.261 0.325 -9999.0 0.0 -0.664 160.0 160.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.116 0.261 -9999.0 0.0 -0.525 109.0 109.0 pancreas development -0.326 0.417 -9999.0 0.0 -0.849 159.0 159.0 HHAT 0.011 0.043 -9999.0 0.0 -0.851 1.0 1.0 PI3K -0.002 0.032 -9999.0 0.0 -0.657 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.158 0.344 -9999.0 0.0 -0.851 81.0 81.0 somite specification -0.116 0.261 -9999.0 0.0 -0.525 109.0 109.0 SHH Np/Cholesterol/PTCH1 -0.099 0.214 -9999.0 0.0 -0.642 15.0 15.0 SHH Np/Cholesterol/PTCH2 -0.092 0.199 -9999.0 0.0 -0.538 67.0 67.0 SHH Np/Cholesterol/Megalin -0.138 0.233 -9999.0 0.0 -0.54 102.0 102.0 SHH 0.007 0.052 -9999.0 0.0 -0.657 1.0 1.0 catabolic process -0.127 0.262 -9999.0 0.0 -0.533 109.0 109.0 SMO/Vitamin D3 -0.102 0.234 -9999.0 0.0 -0.677 15.0 15.0 SHH Np/Cholesterol/Hhip -0.214 0.258 -9999.0 0.0 -0.534 160.0 160.0 LRP2 -0.2 0.373 -9999.0 0.0 -0.851 101.0 101.0 receptor-mediated endocytosis -0.205 0.24 -9999.0 0.0 -0.74 38.0 38.0 SHH Np/Cholesterol/BOC -0.016 0.084 -9999.0 0.0 -0.548 9.0 9.0 SHH Np/Cholesterol/CDO -0.16 0.243 -9999.0 0.0 -0.538 119.0 119.0 mesenchymal cell differentiation 0.212 0.256 0.53 160.0 -9999.0 0.0 160.0 mol:Vitamin D3 -0.098 0.218 -9999.0 0.0 -0.649 15.0 15.0 IHH N/PTCH2 -0.249 0.363 -9999.0 0.0 -0.693 154.0 154.0 CDON -0.236 0.391 -9999.0 0.0 -0.851 118.0 118.0 IHH N/PTCH1 -0.129 0.265 -9999.0 0.0 -0.541 109.0 109.0 Megalin/LRPAP1 -0.162 0.283 -9999.0 0.0 -0.657 101.0 101.0 PTCH2 -0.126 0.318 -9999.0 0.0 -0.851 66.0 66.0 SHH Np/Cholesterol -0.006 0.038 -9999.0 0.0 -0.535 1.0 1.0 PTCH1 -0.127 0.263 -9999.0 0.0 -0.535 109.0 109.0 HHIP -0.327 0.418 -9999.0 0.0 -0.851 159.0 159.0