Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.071 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.003 0.095 -9999.0 0.0 -0.851 5.0 5.0 EPHA2 0.011 0.028 -9999.0 0.0 -0.313 3.0 3.0 MYO6 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.04 0.137 -9999.0 0.0 -0.609 22.0 22.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.04 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.038 0.074 -9999.0 0.0 -9999.0 0.0 0.0 EGF -0.108 0.295 -9999.0 0.0 -0.798 61.0 61.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.073 0.198 -9999.0 0.0 -0.609 49.0 49.0 cortical microtubule organization 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.039 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.0 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.001 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.051 0.024 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.001 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.067 0.158 -9999.0 0.0 -0.448 60.0 60.0 RhoA/GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.047 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.179 0.356 -9999.0 0.0 -0.822 94.0 94.0 DIAPH1 0.0 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.0 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.048 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.044 0.043 -9999.0 0.0 -0.45 3.0 3.0 Ephrin A1/EPHA2 -0.001 0.008 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.038 0.074 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET -0.109 0.174 -9999.0 0.0 -0.502 62.0 62.0 HGF -0.118 0.31 -9999.0 0.0 -0.851 62.0 62.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.087 0.016 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.047 0.024 -9999.0 0.0 -0.441 1.0 1.0 KIFC3 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.04 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.0 0.005 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.064 0.022 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.099 0.184 -9999.0 0.0 -0.448 89.0 89.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.118 0.16 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 0.04 0.025 -9999.0 0.0 -0.47 1.0 1.0 mol:GTP -0.001 0.011 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.067 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.047 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0