Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.092 0.211 -9999.0 0.0 -0.632 23.0 23.0 IHH -0.167 0.325 -9999.0 0.0 -0.715 105.0 105.0 SHH Np/Cholesterol/GAS1 -0.057 0.163 -9999.0 0.0 -0.405 70.0 70.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.056 0.162 0.402 70.0 -9999.0 0.0 70.0 SMO/beta Arrestin2 -0.081 0.208 -9999.0 0.0 -0.538 11.0 11.0 SMO -0.1 0.21 -9999.0 0.0 -0.446 92.0 92.0 AKT1 -0.016 0.099 -9999.0 0.0 -0.341 1.0 1.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.015 0.093 -9999.0 0.0 -0.688 7.0 7.0 ADRBK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.099 0.207 -9999.0 0.0 -0.439 96.0 96.0 STIL -0.071 0.159 -9999.0 0.0 -0.472 11.0 11.0 DHH N/PTCH2 -0.052 0.207 -9999.0 0.0 -0.517 66.0 66.0 DHH N/PTCH1 -0.082 0.193 -9999.0 0.0 -0.382 102.0 102.0 PIK3CA 0.025 0.036 -9999.0 0.0 -0.688 1.0 1.0 DHH 0.021 0.061 -9999.0 0.0 -0.688 3.0 3.0 PTHLH -0.142 0.311 -9999.0 0.0 -1.066 25.0 25.0 determination of left/right symmetry -0.099 0.207 -9999.0 0.0 -0.439 96.0 96.0 PIK3R1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.141 0.307 -9999.0 0.0 -1.047 25.0 25.0 IHH N/Hhip -0.305 0.34 -9999.0 0.0 -0.605 216.0 216.0 DHH N/Hhip -0.176 0.272 -9999.0 0.0 -0.519 155.0 155.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.099 0.207 -9999.0 0.0 -0.439 96.0 96.0 pancreas development -0.254 0.338 -9999.0 0.0 -0.683 155.0 155.0 HHAT 0.024 0.036 -9999.0 0.0 -0.688 1.0 1.0 PI3K 0.038 0.029 -9999.0 0.0 -0.521 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.106 0.27 -9999.0 0.0 -0.641 80.0 80.0 somite specification -0.099 0.207 -9999.0 0.0 -0.439 96.0 96.0 SHH Np/Cholesterol/PTCH1 -0.075 0.163 -9999.0 0.0 -0.508 10.0 10.0 SHH Np/Cholesterol/PTCH2 -0.045 0.154 -9999.0 0.0 -0.39 65.0 65.0 SHH Np/Cholesterol/Megalin -0.078 0.18 -9999.0 0.0 -0.394 97.0 97.0 SHH -0.005 0.031 -9999.0 0.0 -0.521 1.0 1.0 catabolic process -0.1 0.207 -9999.0 0.0 -0.422 108.0 108.0 SMO/Vitamin D3 -0.08 0.186 -9999.0 0.0 -0.552 9.0 9.0 SHH Np/Cholesterol/Hhip -0.143 0.206 -9999.0 0.0 -0.403 154.0 154.0 LRP2 -0.147 0.305 -9999.0 0.0 -0.679 100.0 100.0 receptor-mediated endocytosis -0.143 0.21 -9999.0 0.0 -0.597 33.0 33.0 SHH Np/Cholesterol/BOC 0.013 0.059 -9999.0 0.0 -0.379 8.0 8.0 SHH Np/Cholesterol/CDO -0.097 0.19 -9999.0 0.0 -0.39 117.0 117.0 mesenchymal cell differentiation 0.142 0.205 0.401 154.0 -9999.0 0.0 154.0 mol:Vitamin D3 -0.07 0.171 -9999.0 0.0 -0.513 10.0 10.0 IHH N/PTCH2 -0.18 0.296 -9999.0 0.0 -0.549 150.0 150.0 CDON -0.179 0.323 -9999.0 0.0 -0.688 117.0 117.0 IHH N/PTCH1 -0.097 0.213 -9999.0 0.0 -0.428 108.0 108.0 Megalin/LRPAP1 -0.096 0.238 -9999.0 0.0 -0.51 100.0 100.0 PTCH2 -0.087 0.26 -9999.0 0.0 -0.683 65.0 65.0 SHH Np/Cholesterol 0.009 0.025 -9999.0 0.0 -0.414 1.0 1.0 PTCH1 -0.1 0.208 -9999.0 0.0 -0.424 108.0 108.0 HHIP -0.254 0.338 -9999.0 0.0 -0.684 155.0 155.0