Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.028 0.009 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.022 0.082 0.481 9.0 -9999.0 0.0 9.0 EGFR 0.017 0.079 -9999.0 0.0 -0.688 5.0 5.0 EPHA2 0.025 0.014 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 0.033 0.072 0.445 10.0 -9999.0 0.0 10.0 CTNNB1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.053 0.013 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 0.002 0.111 -9999.0 0.0 -0.542 15.0 15.0 CTNND1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.025 0.052 0.41 6.0 -9999.0 0.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.008 0.061 0.392 6.0 -9999.0 0.0 6.0 EGF -0.071 0.243 -9999.0 0.0 -0.682 55.0 55.0 NCKAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.042 0.173 -9999.0 0.0 -0.541 40.0 40.0 cortical microtubule organization 0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.013 0.052 0.401 6.0 -9999.0 0.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.061 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP 0.006 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.061 0.024 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.015 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.02 0.019 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.067 0.027 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.01 0.146 -9999.0 0.0 -0.367 58.0 58.0 RhoA/GDP 0.056 0.016 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.022 0.056 0.414 7.0 -9999.0 0.0 7.0 IGF-1R heterotetramer 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.121 0.286 -9999.0 0.0 -0.684 83.0 83.0 DIAPH1 0.05 0.048 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway -0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP 0.006 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.022 0.057 0.417 7.0 -9999.0 0.0 7.0 EFNA1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.014 0.043 0.355 2.0 -0.368 2.0 4.0 Ephrin A1/EPHA2 0.047 0.019 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.014 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.009 0.062 0.395 6.0 -9999.0 0.0 6.0 HGF/MET -0.007 0.152 -9999.0 0.0 -0.387 54.0 54.0 HGF -0.076 0.249 -9999.0 0.0 -0.688 58.0 58.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.028 0.009 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.07 0.141 0.514 26.0 -0.328 1.0 27.0 KIAA1543 0.013 0.053 0.374 6.0 -0.362 1.0 7.0 KIFC3 0.021 0.023 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.024 0.038 0.356 3.0 -9999.0 0.0 3.0 NCK1/GIT1 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.021 0.023 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.052 0.413 6.0 -9999.0 0.0 6.0 LIMA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.044 0.107 0.44 20.0 -9999.0 0.0 20.0 adherens junction assembly 0.028 0.091 0.482 11.0 -9999.0 0.0 11.0 IGF-1R heterotetramer/IGF1 -0.033 0.165 -9999.0 0.0 -0.367 78.0 78.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.034 0.073 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 0.025 0.053 0.383 6.0 -0.379 1.0 7.0 mol:GTP 0.059 0.024 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.03 0.066 0.478 6.0 -9999.0 0.0 6.0 cortical actin cytoskeleton stabilization 0.028 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.022 0.056 0.414 7.0 -9999.0 0.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.028 0.009 -9999.0 0.0 -9999.0 0.0 0.0