Uterine Corpus Endometrioid Carcinoma: Correlation between copy number variation genes (focal) and selected clinical features<BR>(primary solid tumor cohort)

Uterine Corpus Endometrioid Carcinoma: Correlation between copy number variation genes (focal) and selected clinical features
(primary solid tumor cohort)

Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)

Overview

Introduction

This pipeline computes the correlation between significant copy number variation (cnv focal) genes and selected clinical features.

Summary

Testing the association between copy number variation 98 arm-level results and 5 clinical features across 447 patients, 156 significant findings detected with Q value < 0.25.

Amp Peak 1(1p35.2) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 2(1p34.2) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 3(1p22.3) cnv correlated to 'AGE'.
Amp Peak 4(1q21.3) cnv correlated to 'AGE'.
Amp Peak 5(1q22) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 7(2p23.2) cnv correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 8(2q13) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 9(3p25.1) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 10(3p14.1) cnv correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 11(3q26.2) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 12(3q26.2) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 13(4p16.3) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 14(5p15.33) cnv correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 15(5q35.3) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 16(6p24.2) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 17(6q25.1) cnv correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 18(7q22.1) cnv correlated to 'Time to Death'.
Amp Peak 19(8p11.21) cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.
Amp Peak 20(8q24.21) cnv correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 21(8q24.21) cnv correlated to 'HISTOLOGICAL.TYPE' and 'COMPLETENESS.OF.RESECTION'.
Amp Peak 22(9p24.2) cnv correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 23(9q34.3) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 25(11p11.2) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 26(11q13.2) cnv correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 27(12p12.1) cnv correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 28(12q13.11) cnv correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 29(12q13.2) cnv correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 30(13q34) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 31(14q24.3) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 32(14q32.33) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 33(16p11.2) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 34(17q11.2) cnv correlated to 'AGE', 'HISTOLOGICAL.TYPE', and 'COMPLETENESS.OF.RESECTION'.
Amp Peak 35(17q12) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 36(17q25.1) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 37(18p11.31) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 38(18q11.2) cnv correlated to 'HISTOLOGICAL.TYPE'.
Amp Peak 39(19p13.2) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 40(19p13.11) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 41(19q12) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 42(20p13) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 43(20q11.21) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 44(20q13.12) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 45(20q13.33) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Amp Peak 46(22q12.2) cnv correlated to 'HISTOLOGICAL.TYPE' and 'COMPLETENESS.OF.RESECTION'.
Del Peak 1(1p36.21) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 2(1p36.11) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 5(2q22.1) cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.
Del Peak 7(3p14.2) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 8(3q13.31) cnv correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 9(4p16.3) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 10(4p15.31) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 11(4q22.1) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 12(4q34.3) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 13(5q11.2) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 14(6q26) cnv correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 15(7p22.3) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 16(7q11.22) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 17(7q31.1) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 18(7q36.3) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 19(8p23.2) cnv correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 20(9p23) cnv correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 21(9q34.11) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 22(10q23.31) cnv correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 23(11p15.5) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 24(11q14.1) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 25(11q25) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 26(12q23.1) cnv correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 27(12q24.33) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 28(13q11) cnv correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 29(13q14.2) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 30(14q13.1) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 31(15q15.1) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 32(15q23) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 33(16p13.3) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 34(16q21) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 35(16q23.1) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 36(17p13.3) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 37(17p12) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 38(17p11.2) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 39(17q11.2) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 40(17q21.2) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 41(18q23) cnv correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 42(19p13.3) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 43(19p12) cnv correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 44(19q13.43) cnv correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 46(22q11.1) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 47(22q12.1) cnv correlated to 'HISTOLOGICAL.TYPE'.
Del Peak 48(22q13.31) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 49(22q13.32) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Del Peak 50(Xp21.1) cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.

Results

Overview of the results

Table 1. Get Full Table Overview of the association between significant copy number variation of 98 arm-level results and 5 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 156 significant findings detected.


		Clinical Features	Time to Death	AGE	HISTOLOGICAL TYPE	RADIATIONS RADIATION REGIMENINDICATION	COMPLETENESS OF RESECTION
	nCNV (%)	nWild-Type	logrank test	t-test	Fisher's exact test	Fisher's exact test	Fisher's exact test
Amp Peak 34(17q11 2)	52 (12%)	395	0.0431 (1.00)	0.000251 (0.0873)	4.04e-16 (1.86e-13)	0.747 (1.00)	0.000336 (0.115)
Amp Peak 1(1p35 2)	41 (9%)	406	0.946 (1.00)	0.000295 (0.102)	3.23e-11 (1.39e-08)	1 (1.00)	0.872 (1.00)
Amp Peak 2(1p34 2)	52 (12%)	395	0.647 (1.00)	0.00012 (0.0427)	6.05e-16 (2.78e-13)	0.333 (1.00)	0.145 (1.00)
Amp Peak 5(1q22)	206 (46%)	241	0.0388 (1.00)	1.46e-07 (5.85e-05)	1.6e-05 (0.00606)	0.534 (1.00)	0.256 (1.00)
Amp Peak 8(2q13)	89 (20%)	358	0.0155 (1.00)	0.000302 (0.104)	2.52e-15 (1.15e-12)	0.796 (1.00)	0.246 (1.00)
Amp Peak 9(3p25 1)	61 (14%)	386	0.402 (1.00)	9.87e-05 (0.0352)	3.04e-09 (1.27e-06)	0.134 (1.00)	0.766 (1.00)
Amp Peak 11(3q26 2)	129 (29%)	318	0.152 (1.00)	1.78e-09 (7.51e-07)	1.21e-22 (5.83e-20)	0.171 (1.00)	0.182 (1.00)
Amp Peak 12(3q26 2)	122 (27%)	325	0.088 (1.00)	1.93e-07 (7.73e-05)	5.47e-23 (2.65e-20)	0.246 (1.00)	0.122 (1.00)
Amp Peak 13(4p16 3)	40 (9%)	407	0.978 (1.00)	8.4e-07 (0.000328)	6.2e-13 (2.74e-10)	0.718 (1.00)	0.726 (1.00)
Amp Peak 15(5q35 3)	39 (9%)	408	0.105 (1.00)	0.00053 (0.179)	1.16e-07 (4.69e-05)	0.463 (1.00)	0.544 (1.00)
Amp Peak 16(6p24 2)	83 (19%)	364	0.827 (1.00)	1.21e-06 (0.000469)	4.15e-17 (1.94e-14)	0.233 (1.00)	0.822 (1.00)
Amp Peak 19(8p11 21)	131 (29%)	316	1.62e-05 (0.0061)	0.402 (1.00)	1.36e-07 (5.49e-05)	0.0417 (1.00)	0.00477 (1.00)
Amp Peak 21(8q24 21)	171 (38%)	276	0.00679 (1.00)	0.238 (1.00)	1.52e-13 (6.77e-11)	0.0142 (1.00)	0.000433 (0.147)
Amp Peak 23(9q34 3)	31 (7%)	416	0.0796 (1.00)	0.000554 (0.186)	2.26e-07 (9.04e-05)	0.839 (1.00)	0.327 (1.00)
Amp Peak 25(11p11 2)	37 (8%)	410	0.0363 (1.00)	0.000241 (0.0839)	5.11e-08 (2.1e-05)	0.851 (1.00)	0.609 (1.00)
Amp Peak 30(13q34)	40 (9%)	407	0.668 (1.00)	8.08e-07 (0.000316)	9.08e-11 (3.9e-08)	1 (1.00)	0.125 (1.00)
Amp Peak 31(14q24 3)	48 (11%)	399	0.494 (1.00)	2.03e-05 (0.0076)	1.62e-11 (7.01e-09)	0.182 (1.00)	0.774 (1.00)
Amp Peak 32(14q32 33)	57 (13%)	390	0.174 (1.00)	0.000239 (0.0838)	1.45e-09 (6.13e-07)	0.162 (1.00)	0.109 (1.00)
Amp Peak 33(16p11 2)	47 (11%)	400	0.0883 (1.00)	0.00031 (0.107)	8.05e-14 (3.61e-11)	1 (1.00)	0.0749 (1.00)
Amp Peak 35(17q12)	53 (12%)	394	0.0604 (1.00)	6.81e-05 (0.0246)	1.86e-16 (8.63e-14)	0.749 (1.00)	0.0467 (1.00)
Amp Peak 36(17q25 1)	75 (17%)	372	0.0504 (1.00)	2.97e-05 (0.0109)	2.56e-15 (1.16e-12)	1 (1.00)	0.263 (1.00)
Amp Peak 37(18p11 31)	67 (15%)	380	0.497 (1.00)	0.00028 (0.097)	2.58e-18 (1.22e-15)	0.0587 (1.00)	0.00948 (1.00)
Amp Peak 39(19p13 2)	69 (15%)	378	0.653 (1.00)	4.89e-11 (2.1e-08)	1.19e-17 (5.58e-15)	0.252 (1.00)	0.795 (1.00)
Amp Peak 40(19p13 11)	68 (15%)	379	0.594 (1.00)	1.45e-10 (6.18e-08)	1.86e-19 (8.8e-17)	0.084 (1.00)	0.306 (1.00)
Amp Peak 41(19q12)	80 (18%)	367	0.00178 (0.575)	3.71e-10 (1.58e-07)	1.93e-34 (9.43e-32)	0.687 (1.00)	0.283 (1.00)
Amp Peak 42(20p13)	87 (19%)	360	0.194 (1.00)	5.29e-05 (0.0193)	4.27e-12 (1.87e-09)	0.24 (1.00)	0.225 (1.00)
Amp Peak 43(20q11 21)	107 (24%)	340	0.0397 (1.00)	3.4e-07 (0.000135)	5.23e-24 (2.54e-21)	0.0687 (1.00)	0.0632 (1.00)
Amp Peak 44(20q13 12)	112 (25%)	335	0.307 (1.00)	9.91e-08 (4.03e-05)	1.1e-20 (5.25e-18)	0.0166 (1.00)	0.035 (1.00)
Amp Peak 45(20q13 33)	110 (25%)	337	0.336 (1.00)	3.68e-07 (0.000145)	1.61e-16 (7.48e-14)	0.00554 (1.00)	0.0264 (1.00)
Amp Peak 46(22q12 2)	43 (10%)	404	0.692 (1.00)	0.00306 (0.968)	5.75e-17 (2.67e-14)	0.221 (1.00)	0.000227 (0.0796)
Del Peak 1(1p36 21)	54 (12%)	393	0.45 (1.00)	3.28e-05 (0.0121)	1.05e-08 (4.36e-06)	0.529 (1.00)	0.367 (1.00)
Del Peak 2(1p36 11)	59 (13%)	388	0.356 (1.00)	3.68e-05 (0.0135)	1.23e-11 (5.37e-09)	0.76 (1.00)	0.00882 (1.00)
Del Peak 5(2q22 1)	34 (8%)	413	9.53e-09 (3.98e-06)	0.00825 (1.00)	2.41e-05 (0.00895)	0.0181 (1.00)	0.0019 (0.613)
Del Peak 7(3p14 2)	57 (13%)	390	0.809 (1.00)	7.54e-05 (0.0272)	6.23e-15 (2.83e-12)	0.439 (1.00)	0.446 (1.00)
Del Peak 9(4p16 3)	66 (15%)	381	0.142 (1.00)	0.000139 (0.049)	2.78e-13 (1.24e-10)	0.47 (1.00)	0.597 (1.00)
Del Peak 10(4p15 31)	66 (15%)	381	0.166 (1.00)	8.27e-05 (0.0297)	7.92e-12 (3.46e-09)	0.11 (1.00)	0.161 (1.00)
Del Peak 11(4q22 1)	76 (17%)	371	0.00702 (1.00)	1.58e-05 (0.00597)	1.33e-22 (6.43e-20)	0.218 (1.00)	0.0485 (1.00)
Del Peak 12(4q34 3)	91 (20%)	356	0.0283 (1.00)	1.14e-05 (0.00433)	2.59e-22 (1.24e-19)	0.521 (1.00)	0.0704 (1.00)
Del Peak 13(5q11 2)	78 (17%)	369	0.0772 (1.00)	6.49e-05 (0.0236)	1.47e-21 (7.04e-19)	0.588 (1.00)	0.261 (1.00)
Del Peak 15(7p22 3)	58 (13%)	389	0.0149 (1.00)	2.51e-05 (0.0093)	1.1e-13 (4.9e-11)	0.541 (1.00)	0.069 (1.00)
Del Peak 16(7q11 22)	31 (7%)	416	0.557 (1.00)	2.09e-05 (0.00778)	9.54e-08 (3.9e-05)	0.689 (1.00)	0.426 (1.00)
Del Peak 17(7q31 1)	39 (9%)	408	0.706 (1.00)	3.68e-06 (0.00142)	4.18e-16 (1.92e-13)	0.588 (1.00)	0.478 (1.00)
Del Peak 18(7q36 3)	49 (11%)	398	0.573 (1.00)	4.14e-08 (1.71e-05)	2.21e-16 (1.02e-13)	0.87 (1.00)	0.235 (1.00)
Del Peak 21(9q34 11)	102 (23%)	345	0.321 (1.00)	7.77e-10 (3.3e-07)	6.56e-18 (3.09e-15)	0.325 (1.00)	0.306 (1.00)
Del Peak 23(11p15 5)	78 (17%)	369	0.0121 (1.00)	3.06e-08 (1.26e-05)	2.7e-21 (1.29e-18)	0.102 (1.00)	0.0212 (1.00)
Del Peak 24(11q14 1)	51 (11%)	396	0.0568 (1.00)	2.66e-05 (0.00984)	3.72e-14 (1.67e-11)	0.52 (1.00)	0.4 (1.00)
Del Peak 25(11q25)	69 (15%)	378	0.00389 (1.00)	0.000158 (0.0558)	6.29e-15 (2.85e-12)	0.032 (1.00)	0.175 (1.00)
Del Peak 27(12q24 33)	45 (10%)	402	0.11 (1.00)	0.000116 (0.0413)	4.36e-13 (1.94e-10)	0.0843 (1.00)	0.0323 (1.00)
Del Peak 29(13q14 2)	72 (16%)	375	0.0407 (1.00)	0.000327 (0.112)	5.28e-05 (0.0193)	0.159 (1.00)	0.203 (1.00)
Del Peak 30(14q13 1)	55 (12%)	392	0.00141 (0.459)	0.000739 (0.247)	9.68e-12 (4.22e-09)	0.53 (1.00)	0.899 (1.00)
Del Peak 31(15q15 1)	104 (23%)	343	0.039 (1.00)	1.44e-08 (5.97e-06)	6.83e-21 (3.26e-18)	0.0658 (1.00)	0.0207 (1.00)
Del Peak 32(15q23)	83 (19%)	364	0.0584 (1.00)	1.79e-05 (0.00674)	7.29e-20 (3.46e-17)	0.233 (1.00)	0.433 (1.00)
Del Peak 33(16p13 3)	62 (14%)	385	0.0338 (1.00)	9.74e-08 (3.97e-05)	1.02e-15 (4.69e-13)	0.55 (1.00)	0.0126 (1.00)
Del Peak 34(16q21)	117 (26%)	330	0.0524 (1.00)	7.63e-09 (3.2e-06)	1.85e-21 (8.88e-19)	0.29 (1.00)	0.122 (1.00)
Del Peak 35(16q23 1)	127 (28%)	320	0.0638 (1.00)	5.24e-08 (2.15e-05)	3.42e-25 (1.67e-22)	0.423 (1.00)	0.00562 (1.00)
Del Peak 36(17p13 3)	85 (19%)	362	0.117 (1.00)	8.02e-05 (0.0289)	4.59e-17 (2.14e-14)	0.293 (1.00)	0.223 (1.00)
Del Peak 37(17p12)	97 (22%)	350	0.0764 (1.00)	1.56e-07 (6.24e-05)	4.91e-24 (2.39e-21)	0.531 (1.00)	0.669 (1.00)
Del Peak 38(17p11 2)	88 (20%)	359	0.0438 (1.00)	1.86e-06 (0.000721)	2.42e-17 (1.14e-14)	0.438 (1.00)	0.778 (1.00)
Del Peak 39(17q11 2)	78 (17%)	369	0.619 (1.00)	8.22e-06 (0.00315)	1.73e-10 (7.36e-08)	0.174 (1.00)	0.219 (1.00)
Del Peak 40(17q21 2)	83 (19%)	364	0.146 (1.00)	1.11e-05 (0.00425)	4.62e-14 (2.07e-11)	0.144 (1.00)	0.113 (1.00)
Del Peak 42(19p13 3)	116 (26%)	331	0.0133 (1.00)	1.81e-11 (7.83e-09)	3.19e-46 (1.56e-43)	0.345 (1.00)	0.0041 (1.00)
Del Peak 46(22q11 1)	66 (15%)	381	0.417 (1.00)	9.75e-05 (0.0349)	1.25e-05 (0.00473)	0.0284 (1.00)	0.787 (1.00)
Del Peak 48(22q13 31)	99 (22%)	348	0.014 (1.00)	2.37e-08 (9.81e-06)	4.51e-17 (2.11e-14)	0.319 (1.00)	0.811 (1.00)
Del Peak 49(22q13 32)	105 (23%)	342	0.0128 (1.00)	5.33e-07 (0.00021)	4.69e-18 (2.21e-15)	0.0877 (1.00)	0.609 (1.00)
Del Peak 50(Xp21 1)	62 (14%)	385	0.00356 (1.00)	0.000158 (0.0558)	1.32e-12 (5.83e-10)	0.55 (1.00)	0.106 (1.00)
Amp Peak 3(1p22 3)	74 (17%)	373	0.732 (1.00)	0.000314 (0.108)	0.00305 (0.965)	0.889 (1.00)	0.502 (1.00)
Amp Peak 4(1q21 3)	194 (43%)	253	0.173 (1.00)	3.09e-06 (0.00119)	0.00268 (0.852)	0.603 (1.00)	0.437 (1.00)
Amp Peak 7(2p23 2)	94 (21%)	353	0.00571 (1.00)	0.00406 (1.00)	6.3e-12 (2.76e-09)	0.0433 (1.00)	0.887 (1.00)
Amp Peak 10(3p14 1)	48 (11%)	399	0.004 (1.00)	0.00956 (1.00)	0.000352 (0.12)	0.0439 (1.00)	0.377 (1.00)
Amp Peak 14(5p15 33)	64 (14%)	383	0.0483 (1.00)	0.00587 (1.00)	1.72e-15 (7.87e-13)	0.658 (1.00)	0.131 (1.00)
Amp Peak 17(6q25 1)	64 (14%)	383	0.821 (1.00)	0.0101 (1.00)	3.39e-05 (0.0124)	0.658 (1.00)	0.253 (1.00)
Amp Peak 18(7q22 1)	70 (16%)	377	0.000538 (0.181)	0.0487 (1.00)	0.00497 (1.00)	0.117 (1.00)	0.512 (1.00)
Amp Peak 20(8q24 21)	163 (36%)	284	0.00131 (0.429)	0.548 (1.00)	1.36e-12 (5.98e-10)	0.042 (1.00)	0.0262 (1.00)
Amp Peak 22(9p24 2)	48 (11%)	399	0.748 (1.00)	0.00576 (1.00)	1.1e-07 (4.45e-05)	0.182 (1.00)	0.436 (1.00)
Amp Peak 26(11q13 2)	56 (13%)	391	0.0906 (1.00)	0.00119 (0.392)	2.53e-07 (0.000101)	1 (1.00)	0.235 (1.00)
Amp Peak 27(12p12 1)	67 (15%)	380	0.74 (1.00)	0.51 (1.00)	2.77e-07 (0.00011)	0.664 (1.00)	0.322 (1.00)
Amp Peak 28(12q13 11)	66 (15%)	381	0.818 (1.00)	0.832 (1.00)	5.46e-07 (0.000215)	0.192 (1.00)	0.252 (1.00)
Amp Peak 29(12q13 2)	74 (17%)	373	0.89 (1.00)	0.076 (1.00)	7.52e-07 (0.000295)	0.0524 (1.00)	0.066 (1.00)
Amp Peak 38(18q11 2)	51 (11%)	396	0.151 (1.00)	0.0105 (1.00)	8.76e-13 (3.87e-10)	0.52 (1.00)	0.076 (1.00)
Del Peak 8(3q13 31)	21 (5%)	426	0.932 (1.00)	0.00342 (1.00)	6.98e-06 (0.00268)	0.632 (1.00)	0.924 (1.00)
Del Peak 14(6q26)	35 (8%)	412	0.267 (1.00)	0.00493 (1.00)	1.05e-08 (4.36e-06)	0.848 (1.00)	0.802 (1.00)
Del Peak 19(8p23 2)	81 (18%)	366	0.357 (1.00)	0.00242 (0.773)	1.08e-23 (5.26e-21)	0.687 (1.00)	0.0146 (1.00)
Del Peak 20(9p23)	51 (11%)	396	0.412 (1.00)	0.00078 (0.26)	9.61e-11 (4.11e-08)	0.333 (1.00)	0.309 (1.00)
Del Peak 22(10q23 31)	53 (12%)	394	0.133 (1.00)	0.00786 (1.00)	1.9e-05 (0.00712)	0.0779 (1.00)	0.0761 (1.00)
Del Peak 26(12q23 1)	34 (8%)	413	0.0541 (1.00)	0.00552 (1.00)	4.05e-11 (1.75e-08)	0.558 (1.00)	0.0213 (1.00)
Del Peak 28(13q11)	67 (15%)	380	0.0114 (1.00)	0.00108 (0.356)	7.87e-10 (3.33e-07)	0.311 (1.00)	0.0483 (1.00)
Del Peak 41(18q23)	73 (16%)	374	0.0109 (1.00)	0.00195 (0.624)	1.3e-14 (5.88e-12)	0.00743 (1.00)	0.0107 (1.00)
Del Peak 43(19p12)	38 (9%)	409	0.111 (1.00)	0.0703 (1.00)	1.35e-07 (5.45e-05)	0.268 (1.00)	0.301 (1.00)
Del Peak 44(19q13 43)	48 (11%)	399	0.00164 (0.534)	0.00213 (0.682)	1.08e-14 (4.89e-12)	1 (1.00)	0.0438 (1.00)
Del Peak 47(22q12 1)	70 (16%)	377	0.196 (1.00)	0.00171 (0.553)	2.09e-06 (0.000808)	0.117 (1.00)	0.665 (1.00)
Amp Peak 6(1q42 3)	184 (41%)	263	0.267 (1.00)	0.000978 (0.325)	0.121 (1.00)	0.6 (1.00)	0.44 (1.00)
Amp Peak 24(10q22 2)	121 (27%)	326	0.186 (1.00)	0.458 (1.00)	0.045 (1.00)	0.727 (1.00)	0.39 (1.00)
Amp Peak 47(Xp11 23)	72 (16%)	375	0.463 (1.00)	0.226 (1.00)	0.0265 (1.00)	0.048 (1.00)	0.311 (1.00)
Amp Peak 48(Xq28)	72 (16%)	375	0.00837 (1.00)	0.108 (1.00)	0.00131 (0.429)	1 (1.00)	0.263 (1.00)
Del Peak 3(1q43)	7 (2%)	440	0.0271 (1.00)	0.0221 (1.00)	0.252 (1.00)	0.109 (1.00)	0.0337 (1.00)
Del Peak 4(2p25 3)	22 (5%)	425	0.0264 (1.00)	0.123 (1.00)	0.00405 (1.00)	0.0993 (1.00)	0.191 (1.00)
Del Peak 6(2q37 3)	40 (9%)	407	0.582 (1.00)	0.000788 (0.262)	0.0103 (1.00)	0.366 (1.00)	0.022 (1.00)
Del Peak 45(20p12 1)	25 (6%)	422	0.0866 (1.00)	0.0531 (1.00)	0.00111 (0.367)	0.823 (1.00)	0.158 (1.00)

'Amp Peak 1(1p35.2) mutation analysis' versus 'AGE'

P value = 0.000295 (t-test), Q value = 0.1

Table S1. Gene #1: 'Amp Peak 1(1p35.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 1(1P35.2) MUTATED	41	68.7 (8.7)
AMP PEAK 1(1P35.2) WILD-TYPE	405	63.1 (11.4)

Figure S1. Get High-res Image Gene #1: 'Amp Peak 1(1p35.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 1(1p35.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.23e-11 (Fisher's exact test), Q value = 1.4e-08

Table S2. Gene #1: 'Amp Peak 1(1p35.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 1(1P35.2) MUTATED	13	4	24
AMP PEAK 1(1P35.2) WILD-TYPE	337	14	55

Figure S2. Get High-res Image Gene #1: 'Amp Peak 1(1p35.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 2(1p34.2) mutation analysis' versus 'AGE'

P value = 0.00012 (t-test), Q value = 0.043

Table S3. Gene #2: 'Amp Peak 2(1p34.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 2(1P34.2) MUTATED	52	68.9 (9.8)
AMP PEAK 2(1P34.2) WILD-TYPE	394	62.9 (11.3)

Figure S3. Get High-res Image Gene #2: 'Amp Peak 2(1p34.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 2(1p34.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.05e-16 (Fisher's exact test), Q value = 2.8e-13

Table S4. Gene #2: 'Amp Peak 2(1p34.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 2(1P34.2) MUTATED	15	6	31
AMP PEAK 2(1P34.2) WILD-TYPE	335	12	48

Figure S4. Get High-res Image Gene #2: 'Amp Peak 2(1p34.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 3(1p22.3) mutation analysis' versus 'AGE'

P value = 0.000314 (t-test), Q value = 0.11

Table S5. Gene #3: 'Amp Peak 3(1p22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 3(1P22.3) MUTATED	74	67.6 (10.1)
AMP PEAK 3(1P22.3) WILD-TYPE	372	62.8 (11.3)

Figure S5. Get High-res Image Gene #3: 'Amp Peak 3(1p22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 4(1q21.3) mutation analysis' versus 'AGE'

P value = 3.09e-06 (t-test), Q value = 0.0012

Table S6. Gene #4: 'Amp Peak 4(1q21.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 4(1Q21.3) MUTATED	194	66.4 (10.5)
AMP PEAK 4(1Q21.3) WILD-TYPE	252	61.4 (11.4)

Figure S6. Get High-res Image Gene #4: 'Amp Peak 4(1q21.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 5(1q22) mutation analysis' versus 'AGE'

P value = 1.46e-07 (t-test), Q value = 5.9e-05

Table S7. Gene #5: 'Amp Peak 5(1q22) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 5(1Q22) MUTATED	206	66.5 (10.5)
AMP PEAK 5(1Q22) WILD-TYPE	240	61.0 (11.3)

Figure S7. Get High-res Image Gene #5: 'Amp Peak 5(1q22) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 5(1q22) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.6e-05 (Fisher's exact test), Q value = 0.0061

Table S8. Gene #5: 'Amp Peak 5(1q22) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 5(1Q22) MUTATED	143	8	55
AMP PEAK 5(1Q22) WILD-TYPE	207	10	24

Figure S8. Get High-res Image Gene #5: 'Amp Peak 5(1q22) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 7(2p23.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.3e-12 (Fisher's exact test), Q value = 2.8e-09

Table S9. Gene #7: 'Amp Peak 7(2p23.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 7(2P23.2) MUTATED	47	7	40
AMP PEAK 7(2P23.2) WILD-TYPE	303	11	39

Figure S9. Get High-res Image Gene #7: 'Amp Peak 7(2p23.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 8(2q13) mutation analysis' versus 'AGE'

P value = 0.000302 (t-test), Q value = 0.1

Table S10. Gene #8: 'Amp Peak 8(2q13) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 8(2Q13) MUTATED	88	67.0 (9.1)
AMP PEAK 8(2Q13) WILD-TYPE	358	62.7 (11.6)

Figure S10. Get High-res Image Gene #8: 'Amp Peak 8(2q13) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 8(2q13) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.52e-15 (Fisher's exact test), Q value = 1.1e-12

Table S11. Gene #8: 'Amp Peak 8(2q13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 8(2Q13) MUTATED	41	4	44
AMP PEAK 8(2Q13) WILD-TYPE	309	14	35

Figure S11. Get High-res Image Gene #8: 'Amp Peak 8(2q13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 9(3p25.1) mutation analysis' versus 'AGE'

P value = 9.87e-05 (t-test), Q value = 0.035

Table S12. Gene #9: 'Amp Peak 9(3p25.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 9(3P25.1) MUTATED	61	68.9 (10.9)
AMP PEAK 9(3P25.1) WILD-TYPE	385	62.7 (11.1)

Figure S12. Get High-res Image Gene #9: 'Amp Peak 9(3p25.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 9(3p25.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.04e-09 (Fisher's exact test), Q value = 1.3e-06

Table S13. Gene #9: 'Amp Peak 9(3p25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 9(3P25.1) MUTATED	30	1	30
AMP PEAK 9(3P25.1) WILD-TYPE	320	17	49

Figure S13. Get High-res Image Gene #9: 'Amp Peak 9(3p25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 10(3p14.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 0.000352 (Fisher's exact test), Q value = 0.12

Table S14. Gene #10: 'Amp Peak 10(3p14.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 10(3P14.1) MUTATED	27	2	19
AMP PEAK 10(3P14.1) WILD-TYPE	323	16	60

Figure S14. Get High-res Image Gene #10: 'Amp Peak 10(3p14.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 11(3q26.2) mutation analysis' versus 'AGE'

P value = 1.78e-09 (t-test), Q value = 7.5e-07

Table S15. Gene #11: 'Amp Peak 11(3q26.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 11(3Q26.2) MUTATED	129	68.2 (9.5)
AMP PEAK 11(3Q26.2) WILD-TYPE	317	61.7 (11.4)

Figure S15. Get High-res Image Gene #11: 'Amp Peak 11(3q26.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 11(3q26.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.21e-22 (Fisher's exact test), Q value = 5.8e-20

Table S16. Gene #11: 'Amp Peak 11(3q26.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 11(3Q26.2) MUTATED	62	7	60
AMP PEAK 11(3Q26.2) WILD-TYPE	288	11	19

Figure S16. Get High-res Image Gene #11: 'Amp Peak 11(3q26.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 12(3q26.2) mutation analysis' versus 'AGE'

P value = 1.93e-07 (t-test), Q value = 7.7e-05

Table S17. Gene #12: 'Amp Peak 12(3q26.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 12(3Q26.2) MUTATED	122	67.7 (9.5)
AMP PEAK 12(3Q26.2) WILD-TYPE	324	62.0 (11.5)

Figure S17. Get High-res Image Gene #12: 'Amp Peak 12(3q26.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 12(3q26.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.47e-23 (Fisher's exact test), Q value = 2.6e-20

Table S18. Gene #12: 'Amp Peak 12(3q26.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 12(3Q26.2) MUTATED	57	6	59
AMP PEAK 12(3Q26.2) WILD-TYPE	293	12	20

Figure S18. Get High-res Image Gene #12: 'Amp Peak 12(3q26.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 13(4p16.3) mutation analysis' versus 'AGE'

P value = 8.4e-07 (t-test), Q value = 0.00033

Table S19. Gene #13: 'Amp Peak 13(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 13(4P16.3) MUTATED	40	70.9 (8.4)
AMP PEAK 13(4P16.3) WILD-TYPE	406	62.9 (11.3)

Figure S19. Get High-res Image Gene #13: 'Amp Peak 13(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 13(4p16.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.2e-13 (Fisher's exact test), Q value = 2.7e-10

Table S20. Gene #13: 'Amp Peak 13(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 13(4P16.3) MUTATED	12	1	27
AMP PEAK 13(4P16.3) WILD-TYPE	338	17	52

Figure S20. Get High-res Image Gene #13: 'Amp Peak 13(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 14(5p15.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.72e-15 (Fisher's exact test), Q value = 7.9e-13

Table S21. Gene #14: 'Amp Peak 14(5p15.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 14(5P15.33) MUTATED	24	3	37
AMP PEAK 14(5P15.33) WILD-TYPE	326	15	42

Figure S21. Get High-res Image Gene #14: 'Amp Peak 14(5p15.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 15(5q35.3) mutation analysis' versus 'AGE'

P value = 0.00053 (t-test), Q value = 0.18

Table S22. Gene #15: 'Amp Peak 15(5q35.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 15(5Q35.3) MUTATED	39	69.7 (10.7)
AMP PEAK 15(5Q35.3) WILD-TYPE	407	63.0 (11.1)

Figure S22. Get High-res Image Gene #15: 'Amp Peak 15(5q35.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 15(5q35.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.16e-07 (Fisher's exact test), Q value = 4.7e-05

Table S23. Gene #15: 'Amp Peak 15(5q35.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 15(5Q35.3) MUTATED	16	2	21
AMP PEAK 15(5Q35.3) WILD-TYPE	334	16	58

Figure S23. Get High-res Image Gene #15: 'Amp Peak 15(5q35.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 16(6p24.2) mutation analysis' versus 'AGE'

P value = 1.21e-06 (t-test), Q value = 0.00047

Table S24. Gene #16: 'Amp Peak 16(6p24.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 16(6P24.2) MUTATED	83	68.7 (9.9)
AMP PEAK 16(6P24.2) WILD-TYPE	363	62.4 (11.2)

Figure S24. Get High-res Image Gene #16: 'Amp Peak 16(6p24.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 16(6p24.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.15e-17 (Fisher's exact test), Q value = 1.9e-14

Table S25. Gene #16: 'Amp Peak 16(6p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 16(6P24.2) MUTATED	35	4	44
AMP PEAK 16(6P24.2) WILD-TYPE	315	14	35

Figure S25. Get High-res Image Gene #16: 'Amp Peak 16(6p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 17(6q25.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.39e-05 (Fisher's exact test), Q value = 0.012

Table S26. Gene #17: 'Amp Peak 17(6q25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 17(6Q25.1) MUTATED	37	2	25
AMP PEAK 17(6Q25.1) WILD-TYPE	313	16	54

Figure S26. Get High-res Image Gene #17: 'Amp Peak 17(6q25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 18(7q22.1) mutation analysis' versus 'Time to Death'

P value = 0.000538 (logrank test), Q value = 0.18

Table S27. Gene #18: 'Amp Peak 18(7q22.1) mutation analysis' versus Clinical Feature #1: 'Time to Death'

	nPatients	nDeath	Duration Range (Median), Month
ALL	442	41	0.0 - 187.1 (15.9)
AMP PEAK 18(7Q22.1) MUTATED	68	13	0.0 - 113.2 (13.1)
AMP PEAK 18(7Q22.1) WILD-TYPE	374	28	0.1 - 187.1 (16.4)

Figure S27. Get High-res Image Gene #18: 'Amp Peak 18(7q22.1) mutation analysis' versus Clinical Feature #1: 'Time to Death'

'Amp Peak 19(8p11.21) mutation analysis' versus 'Time to Death'

P value = 1.62e-05 (logrank test), Q value = 0.0061

Table S28. Gene #19: 'Amp Peak 19(8p11.21) mutation analysis' versus Clinical Feature #1: 'Time to Death'

	nPatients	nDeath	Duration Range (Median), Month
ALL	442	41	0.0 - 187.1 (15.9)
AMP PEAK 19(8P11.21) MUTATED	129	22	0.0 - 113.2 (11.5)
AMP PEAK 19(8P11.21) WILD-TYPE	313	19	0.0 - 187.1 (16.9)

Figure S28. Get High-res Image Gene #19: 'Amp Peak 19(8p11.21) mutation analysis' versus Clinical Feature #1: 'Time to Death'

'Amp Peak 19(8p11.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.36e-07 (Fisher's exact test), Q value = 5.5e-05

Table S29. Gene #19: 'Amp Peak 19(8p11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 19(8P11.21) MUTATED	81	6	44
AMP PEAK 19(8P11.21) WILD-TYPE	269	12	35

Figure S29. Get High-res Image Gene #19: 'Amp Peak 19(8p11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 20(8q24.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.36e-12 (Fisher's exact test), Q value = 6e-10

Table S30. Gene #20: 'Amp Peak 20(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 20(8Q24.21) MUTATED	98	8	57
AMP PEAK 20(8Q24.21) WILD-TYPE	252	10	22

Figure S30. Get High-res Image Gene #20: 'Amp Peak 20(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 21(8q24.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.52e-13 (Fisher's exact test), Q value = 6.8e-11

Table S31. Gene #21: 'Amp Peak 21(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 21(8Q24.21) MUTATED	104	7	60
AMP PEAK 21(8Q24.21) WILD-TYPE	246	11	19

Figure S31. Get High-res Image Gene #21: 'Amp Peak 21(8q24.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 21(8q24.21) mutation analysis' versus 'COMPLETENESS.OF.RESECTION'

P value = 0.000433 (Fisher's exact test), Q value = 0.15

Table S32. Gene #21: 'Amp Peak 21(8q24.21) mutation analysis' versus Clinical Feature #5: 'COMPLETENESS.OF.RESECTION'

nPatients	R0	R1	R2	RX
ALL	307	24	15	24
AMP PEAK 21(8Q24.21) MUTATED	115	5	13	10
AMP PEAK 21(8Q24.21) WILD-TYPE	192	19	2	14

Figure S32. Get High-res Image Gene #21: 'Amp Peak 21(8q24.21) mutation analysis' versus Clinical Feature #5: 'COMPLETENESS.OF.RESECTION'

'Amp Peak 22(9p24.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.1e-07 (Fisher's exact test), Q value = 4.4e-05

Table S33. Gene #22: 'Amp Peak 22(9p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 22(9P24.2) MUTATED	22	2	24
AMP PEAK 22(9P24.2) WILD-TYPE	328	16	55

Figure S33. Get High-res Image Gene #22: 'Amp Peak 22(9p24.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 23(9q34.3) mutation analysis' versus 'AGE'

P value = 0.000554 (t-test), Q value = 0.19

Table S34. Gene #23: 'Amp Peak 23(9q34.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 23(9Q34.3) MUTATED	31	69.0 (8.0)
AMP PEAK 23(9Q34.3) WILD-TYPE	415	63.2 (11.4)

Figure S34. Get High-res Image Gene #23: 'Amp Peak 23(9q34.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 23(9q34.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.26e-07 (Fisher's exact test), Q value = 9e-05

Table S35. Gene #23: 'Amp Peak 23(9q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 23(9Q34.3) MUTATED	11	4	16
AMP PEAK 23(9Q34.3) WILD-TYPE	339	14	63

Figure S35. Get High-res Image Gene #23: 'Amp Peak 23(9q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 25(11p11.2) mutation analysis' versus 'AGE'

P value = 0.000241 (t-test), Q value = 0.084

Table S36. Gene #25: 'Amp Peak 25(11p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 25(11P11.2) MUTATED	37	69.7 (9.6)
AMP PEAK 25(11P11.2) WILD-TYPE	409	63.0 (11.2)

Figure S36. Get High-res Image Gene #25: 'Amp Peak 25(11p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 25(11p11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.11e-08 (Fisher's exact test), Q value = 2.1e-05

Table S37. Gene #25: 'Amp Peak 25(11p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 25(11P11.2) MUTATED	14	3	20
AMP PEAK 25(11P11.2) WILD-TYPE	336	15	59

Figure S37. Get High-res Image Gene #25: 'Amp Peak 25(11p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 26(11q13.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.53e-07 (Fisher's exact test), Q value = 1e-04

Table S38. Gene #26: 'Amp Peak 26(11q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 26(11Q13.2) MUTATED	28	2	26
AMP PEAK 26(11Q13.2) WILD-TYPE	322	16	53

Figure S38. Get High-res Image Gene #26: 'Amp Peak 26(11q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 27(12p12.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.77e-07 (Fisher's exact test), Q value = 0.00011

Table S39. Gene #27: 'Amp Peak 27(12p12.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 27(12P12.1) MUTATED	36	2	29
AMP PEAK 27(12P12.1) WILD-TYPE	314	16	50

Figure S39. Get High-res Image Gene #27: 'Amp Peak 27(12p12.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 28(12q13.11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.46e-07 (Fisher's exact test), Q value = 0.00021

Table S40. Gene #28: 'Amp Peak 28(12q13.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 28(12Q13.11) MUTATED	35	3	28
AMP PEAK 28(12Q13.11) WILD-TYPE	315	15	51

Figure S40. Get High-res Image Gene #28: 'Amp Peak 28(12q13.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 29(12q13.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.52e-07 (Fisher's exact test), Q value = 0.00029

Table S41. Gene #29: 'Amp Peak 29(12q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 29(12Q13.2) MUTATED	41	3	30
AMP PEAK 29(12Q13.2) WILD-TYPE	309	15	49

Figure S41. Get High-res Image Gene #29: 'Amp Peak 29(12q13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 30(13q34) mutation analysis' versus 'AGE'

P value = 8.08e-07 (t-test), Q value = 0.00032

Table S42. Gene #30: 'Amp Peak 30(13q34) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 30(13Q34) MUTATED	40	69.9 (7.1)
AMP PEAK 30(13Q34) WILD-TYPE	406	63.0 (11.4)

Figure S42. Get High-res Image Gene #30: 'Amp Peak 30(13q34) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 30(13q34) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 9.08e-11 (Fisher's exact test), Q value = 3.9e-08

Table S43. Gene #30: 'Amp Peak 30(13q34) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 30(13Q34) MUTATED	13	3	24
AMP PEAK 30(13Q34) WILD-TYPE	337	15	55

Figure S43. Get High-res Image Gene #30: 'Amp Peak 30(13q34) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 31(14q24.3) mutation analysis' versus 'AGE'

P value = 2.03e-05 (t-test), Q value = 0.0076

Table S44. Gene #31: 'Amp Peak 31(14q24.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 31(14Q24.3) MUTATED	48	69.0 (8.4)
AMP PEAK 31(14Q24.3) WILD-TYPE	398	62.9 (11.4)

Figure S44. Get High-res Image Gene #31: 'Amp Peak 31(14q24.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 31(14q24.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.62e-11 (Fisher's exact test), Q value = 7e-09

Table S45. Gene #31: 'Amp Peak 31(14q24.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 31(14Q24.3) MUTATED	17	4	27
AMP PEAK 31(14Q24.3) WILD-TYPE	333	14	52

Figure S45. Get High-res Image Gene #31: 'Amp Peak 31(14q24.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 32(14q32.33) mutation analysis' versus 'AGE'

P value = 0.000239 (t-test), Q value = 0.084

Table S46. Gene #32: 'Amp Peak 32(14q32.33) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 32(14Q32.33) MUTATED	57	68.2 (9.4)
AMP PEAK 32(14Q32.33) WILD-TYPE	389	62.9 (11.4)

Figure S46. Get High-res Image Gene #32: 'Amp Peak 32(14q32.33) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 32(14q32.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.45e-09 (Fisher's exact test), Q value = 6.1e-07

Table S47. Gene #32: 'Amp Peak 32(14q32.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 32(14Q32.33) MUTATED	25	4	28
AMP PEAK 32(14Q32.33) WILD-TYPE	325	14	51

Figure S47. Get High-res Image Gene #32: 'Amp Peak 32(14q32.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 33(16p11.2) mutation analysis' versus 'AGE'

P value = 0.00031 (t-test), Q value = 0.11

Table S48. Gene #33: 'Amp Peak 33(16p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 33(16P11.2) MUTATED	47	68.3 (8.6)
AMP PEAK 33(16P11.2) WILD-TYPE	399	63.0 (11.4)

Figure S48. Get High-res Image Gene #33: 'Amp Peak 33(16p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 33(16p11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.05e-14 (Fisher's exact test), Q value = 3.6e-11

Table S49. Gene #33: 'Amp Peak 33(16p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 33(16P11.2) MUTATED	15	2	30
AMP PEAK 33(16P11.2) WILD-TYPE	335	16	49

Figure S49. Get High-res Image Gene #33: 'Amp Peak 33(16p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 34(17q11.2) mutation analysis' versus 'AGE'

P value = 0.000251 (t-test), Q value = 0.087

Table S50. Gene #34: 'Amp Peak 34(17q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 34(17Q11.2) MUTATED	52	68.0 (8.5)
AMP PEAK 34(17Q11.2) WILD-TYPE	394	63.0 (11.4)

Figure S50. Get High-res Image Gene #34: 'Amp Peak 34(17q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 34(17q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.04e-16 (Fisher's exact test), Q value = 1.9e-13

Table S51. Gene #34: 'Amp Peak 34(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 34(17Q11.2) MUTATED	15	5	32
AMP PEAK 34(17Q11.2) WILD-TYPE	335	13	47

Figure S51. Get High-res Image Gene #34: 'Amp Peak 34(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 34(17q11.2) mutation analysis' versus 'COMPLETENESS.OF.RESECTION'

P value = 0.000336 (Fisher's exact test), Q value = 0.11

Table S52. Gene #34: 'Amp Peak 34(17q11.2) mutation analysis' versus Clinical Feature #5: 'COMPLETENESS.OF.RESECTION'

nPatients	R0	R1	R2	RX
ALL	307	24	15	24
AMP PEAK 34(17Q11.2) MUTATED	28	7	6	4
AMP PEAK 34(17Q11.2) WILD-TYPE	279	17	9	20

Figure S52. Get High-res Image Gene #34: 'Amp Peak 34(17q11.2) mutation analysis' versus Clinical Feature #5: 'COMPLETENESS.OF.RESECTION'

'Amp Peak 35(17q12) mutation analysis' versus 'AGE'

P value = 6.81e-05 (t-test), Q value = 0.025

Table S53. Gene #35: 'Amp Peak 35(17q12) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 35(17Q12) MUTATED	53	68.8 (9.4)
AMP PEAK 35(17Q12) WILD-TYPE	393	62.9 (11.3)

Figure S53. Get High-res Image Gene #35: 'Amp Peak 35(17q12) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 35(17q12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.86e-16 (Fisher's exact test), Q value = 8.6e-14

Table S54. Gene #35: 'Amp Peak 35(17q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 35(17Q12) MUTATED	16	3	34
AMP PEAK 35(17Q12) WILD-TYPE	334	15	45

Figure S54. Get High-res Image Gene #35: 'Amp Peak 35(17q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 36(17q25.1) mutation analysis' versus 'AGE'

P value = 2.97e-05 (t-test), Q value = 0.011

Table S55. Gene #36: 'Amp Peak 36(17q25.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 36(17Q25.1) MUTATED	75	67.9 (9.0)
AMP PEAK 36(17Q25.1) WILD-TYPE	371	62.7 (11.5)

Figure S55. Get High-res Image Gene #36: 'Amp Peak 36(17q25.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 36(17q25.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.56e-15 (Fisher's exact test), Q value = 1.2e-12

Table S56. Gene #36: 'Amp Peak 36(17q25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 36(17Q25.1) MUTATED	30	8	37
AMP PEAK 36(17Q25.1) WILD-TYPE	320	10	42

Figure S56. Get High-res Image Gene #36: 'Amp Peak 36(17q25.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 37(18p11.31) mutation analysis' versus 'AGE'

P value = 0.00028 (t-test), Q value = 0.097

Table S57. Gene #37: 'Amp Peak 37(18p11.31) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 37(18P11.31) MUTATED	67	67.6 (9.2)
AMP PEAK 37(18P11.31) WILD-TYPE	379	62.9 (11.4)

Figure S57. Get High-res Image Gene #37: 'Amp Peak 37(18p11.31) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 37(18p11.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.58e-18 (Fisher's exact test), Q value = 1.2e-15

Table S58. Gene #37: 'Amp Peak 37(18p11.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 37(18P11.31) MUTATED	23	4	40
AMP PEAK 37(18P11.31) WILD-TYPE	327	14	39

Figure S58. Get High-res Image Gene #37: 'Amp Peak 37(18p11.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 38(18q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 8.76e-13 (Fisher's exact test), Q value = 3.9e-10

Table S59. Gene #38: 'Amp Peak 38(18q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 38(18Q11.2) MUTATED	18	3	30
AMP PEAK 38(18Q11.2) WILD-TYPE	332	15	49

Figure S59. Get High-res Image Gene #38: 'Amp Peak 38(18q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 39(19p13.2) mutation analysis' versus 'AGE'

P value = 4.89e-11 (t-test), Q value = 2.1e-08

Table S60. Gene #39: 'Amp Peak 39(19p13.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 39(19P13.2) MUTATED	69	70.7 (8.4)
AMP PEAK 39(19P13.2) WILD-TYPE	377	62.3 (11.2)

Figure S60. Get High-res Image Gene #39: 'Amp Peak 39(19p13.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 39(19p13.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.19e-17 (Fisher's exact test), Q value = 5.6e-15

Table S61. Gene #39: 'Amp Peak 39(19p13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 39(19P13.2) MUTATED	24	7	38
AMP PEAK 39(19P13.2) WILD-TYPE	326	11	41

Figure S61. Get High-res Image Gene #39: 'Amp Peak 39(19p13.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 40(19p13.11) mutation analysis' versus 'AGE'

P value = 1.45e-10 (t-test), Q value = 6.2e-08

Table S62. Gene #40: 'Amp Peak 40(19p13.11) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 40(19P13.11) MUTATED	68	71.0 (9.0)
AMP PEAK 40(19P13.11) WILD-TYPE	378	62.2 (11.1)

Figure S62. Get High-res Image Gene #40: 'Amp Peak 40(19p13.11) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 40(19p13.11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.86e-19 (Fisher's exact test), Q value = 8.8e-17

Table S63. Gene #40: 'Amp Peak 40(19p13.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 40(19P13.11) MUTATED	22	6	40
AMP PEAK 40(19P13.11) WILD-TYPE	328	12	39

Figure S63. Get High-res Image Gene #40: 'Amp Peak 40(19p13.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 41(19q12) mutation analysis' versus 'AGE'

P value = 3.71e-10 (t-test), Q value = 1.6e-07

Table S64. Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 41(19Q12) MUTATED	80	69.5 (8.1)
AMP PEAK 41(19Q12) WILD-TYPE	366	62.3 (11.4)

Figure S64. Get High-res Image Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 41(19q12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.93e-34 (Fisher's exact test), Q value = 9.4e-32

Table S65. Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 41(19Q12) MUTATED	18	9	53
AMP PEAK 41(19Q12) WILD-TYPE	332	9	26

Figure S65. Get High-res Image Gene #41: 'Amp Peak 41(19q12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 42(20p13) mutation analysis' versus 'AGE'

P value = 5.29e-05 (t-test), Q value = 0.019

Table S66. Gene #42: 'Amp Peak 42(20p13) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 42(20P13) MUTATED	87	68.1 (11.2)
AMP PEAK 42(20P13) WILD-TYPE	359	62.5 (11.0)

Figure S66. Get High-res Image Gene #42: 'Amp Peak 42(20p13) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 42(20p13) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.27e-12 (Fisher's exact test), Q value = 1.9e-09

Table S67. Gene #42: 'Amp Peak 42(20p13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 42(20P13) MUTATED	43	4	40
AMP PEAK 42(20P13) WILD-TYPE	307	14	39

Figure S67. Get High-res Image Gene #42: 'Amp Peak 42(20p13) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 43(20q11.21) mutation analysis' versus 'AGE'

P value = 3.4e-07 (t-test), Q value = 0.00013

Table S68. Gene #43: 'Amp Peak 43(20q11.21) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 43(20Q11.21) MUTATED	107	68.2 (10.0)
AMP PEAK 43(20Q11.21) WILD-TYPE	339	62.1 (11.3)

Figure S68. Get High-res Image Gene #43: 'Amp Peak 43(20q11.21) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 43(20q11.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.23e-24 (Fisher's exact test), Q value = 2.5e-21

Table S69. Gene #43: 'Amp Peak 43(20q11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 43(20Q11.21) MUTATED	45	6	56
AMP PEAK 43(20Q11.21) WILD-TYPE	305	12	23

Figure S69. Get High-res Image Gene #43: 'Amp Peak 43(20q11.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 44(20q13.12) mutation analysis' versus 'AGE'

P value = 9.91e-08 (t-test), Q value = 4e-05

Table S70. Gene #44: 'Amp Peak 44(20q13.12) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 44(20Q13.12) MUTATED	112	68.3 (10.3)
AMP PEAK 44(20Q13.12) WILD-TYPE	334	62.0 (11.1)

Figure S70. Get High-res Image Gene #44: 'Amp Peak 44(20q13.12) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 44(20q13.12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.1e-20 (Fisher's exact test), Q value = 5.3e-18

Table S71. Gene #44: 'Amp Peak 44(20q13.12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 44(20Q13.12) MUTATED	51	7	54
AMP PEAK 44(20Q13.12) WILD-TYPE	299	11	25

Figure S71. Get High-res Image Gene #44: 'Amp Peak 44(20q13.12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 45(20q13.33) mutation analysis' versus 'AGE'

P value = 3.68e-07 (t-test), Q value = 0.00015

Table S72. Gene #45: 'Amp Peak 45(20q13.33) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
AMP PEAK 45(20Q13.33) MUTATED	110	68.2 (10.5)
AMP PEAK 45(20Q13.33) WILD-TYPE	336	62.1 (11.1)

Figure S72. Get High-res Image Gene #45: 'Amp Peak 45(20q13.33) mutation analysis' versus Clinical Feature #2: 'AGE'

'Amp Peak 45(20q13.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.61e-16 (Fisher's exact test), Q value = 7.5e-14

Table S73. Gene #45: 'Amp Peak 45(20q13.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 45(20Q13.33) MUTATED	54	6	50
AMP PEAK 45(20Q13.33) WILD-TYPE	296	12	29

Figure S73. Get High-res Image Gene #45: 'Amp Peak 45(20q13.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 46(22q12.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.75e-17 (Fisher's exact test), Q value = 2.7e-14

Table S74. Gene #46: 'Amp Peak 46(22q12.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
AMP PEAK 46(22Q12.2) MUTATED	10	2	31
AMP PEAK 46(22Q12.2) WILD-TYPE	340	16	48

Figure S74. Get High-res Image Gene #46: 'Amp Peak 46(22q12.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Amp Peak 46(22q12.2) mutation analysis' versus 'COMPLETENESS.OF.RESECTION'

P value = 0.000227 (Fisher's exact test), Q value = 0.08

Table S75. Gene #46: 'Amp Peak 46(22q12.2) mutation analysis' versus Clinical Feature #5: 'COMPLETENESS.OF.RESECTION'

nPatients	R0	R1	R2	RX
ALL	307	24	15	24
AMP PEAK 46(22Q12.2) MUTATED	23	2	7	4
AMP PEAK 46(22Q12.2) WILD-TYPE	284	22	8	20

Figure S75. Get High-res Image Gene #46: 'Amp Peak 46(22q12.2) mutation analysis' versus Clinical Feature #5: 'COMPLETENESS.OF.RESECTION'

'Del Peak 1(1p36.21) mutation analysis' versus 'AGE'

P value = 3.28e-05 (t-test), Q value = 0.012

Table S76. Gene #49: 'Del Peak 1(1p36.21) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 1(1P36.21) MUTATED	54	69.5 (10.3)
DEL PEAK 1(1P36.21) WILD-TYPE	392	62.8 (11.1)

Figure S76. Get High-res Image Gene #49: 'Del Peak 1(1p36.21) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 1(1p36.21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.05e-08 (Fisher's exact test), Q value = 4.4e-06

Table S77. Gene #49: 'Del Peak 1(1p36.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 1(1P36.21) MUTATED	24	4	26
DEL PEAK 1(1P36.21) WILD-TYPE	326	14	53

Figure S77. Get High-res Image Gene #49: 'Del Peak 1(1p36.21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 2(1p36.11) mutation analysis' versus 'AGE'

P value = 3.68e-05 (t-test), Q value = 0.013

Table S78. Gene #50: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 2(1P36.11) MUTATED	59	68.8 (9.7)
DEL PEAK 2(1P36.11) WILD-TYPE	387	62.8 (11.3)

Figure S78. Get High-res Image Gene #50: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 2(1p36.11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.23e-11 (Fisher's exact test), Q value = 5.4e-09

Table S79. Gene #50: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 2(1P36.11) MUTATED	24	4	31
DEL PEAK 2(1P36.11) WILD-TYPE	326	14	48

Figure S79. Get High-res Image Gene #50: 'Del Peak 2(1p36.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 5(2q22.1) mutation analysis' versus 'Time to Death'

P value = 9.53e-09 (logrank test), Q value = 4e-06

Table S80. Gene #53: 'Del Peak 5(2q22.1) mutation analysis' versus Clinical Feature #1: 'Time to Death'

	nPatients	nDeath	Duration Range (Median), Month
ALL	442	41	0.0 - 187.1 (15.9)
DEL PEAK 5(2Q22.1) MUTATED	34	10	0.1 - 113.2 (7.9)
DEL PEAK 5(2Q22.1) WILD-TYPE	408	31	0.0 - 187.1 (16.7)

Figure S80. Get High-res Image Gene #53: 'Del Peak 5(2q22.1) mutation analysis' versus Clinical Feature #1: 'Time to Death'

'Del Peak 5(2q22.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.41e-05 (Fisher's exact test), Q value = 0.009

Table S81. Gene #53: 'Del Peak 5(2q22.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 5(2Q22.1) MUTATED	16	1	17
DEL PEAK 5(2Q22.1) WILD-TYPE	334	17	62

Figure S81. Get High-res Image Gene #53: 'Del Peak 5(2q22.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 7(3p14.2) mutation analysis' versus 'AGE'

P value = 7.54e-05 (t-test), Q value = 0.027

Table S82. Gene #55: 'Del Peak 7(3p14.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 7(3P14.2) MUTATED	57	67.6 (7.2)
DEL PEAK 7(3P14.2) WILD-TYPE	389	63.0 (11.6)

Figure S82. Get High-res Image Gene #55: 'Del Peak 7(3p14.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 7(3p14.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.23e-15 (Fisher's exact test), Q value = 2.8e-12

Table S83. Gene #55: 'Del Peak 7(3p14.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 7(3P14.2) MUTATED	19	6	32
DEL PEAK 7(3P14.2) WILD-TYPE	331	12	47

Figure S83. Get High-res Image Gene #55: 'Del Peak 7(3p14.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 8(3q13.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.98e-06 (Fisher's exact test), Q value = 0.0027

Table S84. Gene #56: 'Del Peak 8(3q13.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 8(3Q13.31) MUTATED	7	1	13
DEL PEAK 8(3Q13.31) WILD-TYPE	343	17	66

Figure S84. Get High-res Image Gene #56: 'Del Peak 8(3q13.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 9(4p16.3) mutation analysis' versus 'AGE'

P value = 0.000139 (t-test), Q value = 0.049

Table S85. Gene #57: 'Del Peak 9(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 9(4P16.3) MUTATED	66	67.9 (9.2)
DEL PEAK 9(4P16.3) WILD-TYPE	380	62.8 (11.4)

Figure S85. Get High-res Image Gene #57: 'Del Peak 9(4p16.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 9(4p16.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.78e-13 (Fisher's exact test), Q value = 1.2e-10

Table S86. Gene #57: 'Del Peak 9(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 9(4P16.3) MUTATED	27	4	35
DEL PEAK 9(4P16.3) WILD-TYPE	323	14	44

Figure S86. Get High-res Image Gene #57: 'Del Peak 9(4p16.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 10(4p15.31) mutation analysis' versus 'AGE'

P value = 8.27e-05 (t-test), Q value = 0.03

Table S87. Gene #58: 'Del Peak 10(4p15.31) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 10(4P15.31) MUTATED	66	68.1 (9.5)
DEL PEAK 10(4P15.31) WILD-TYPE	380	62.8 (11.4)

Figure S87. Get High-res Image Gene #58: 'Del Peak 10(4p15.31) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 10(4p15.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.92e-12 (Fisher's exact test), Q value = 3.5e-09

Table S88. Gene #58: 'Del Peak 10(4p15.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 10(4P15.31) MUTATED	29	3	34
DEL PEAK 10(4P15.31) WILD-TYPE	321	15	45

Figure S88. Get High-res Image Gene #58: 'Del Peak 10(4p15.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 11(4q22.1) mutation analysis' versus 'AGE'

P value = 1.58e-05 (t-test), Q value = 0.006

Table S89. Gene #59: 'Del Peak 11(4q22.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 11(4Q22.1) MUTATED	76	68.1 (9.2)
DEL PEAK 11(4Q22.1) WILD-TYPE	370	62.6 (11.4)

Figure S89. Get High-res Image Gene #59: 'Del Peak 11(4q22.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 11(4q22.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.33e-22 (Fisher's exact test), Q value = 6.4e-20

Table S90. Gene #59: 'Del Peak 11(4q22.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 11(4Q22.1) MUTATED	25	5	46
DEL PEAK 11(4Q22.1) WILD-TYPE	325	13	33

Figure S90. Get High-res Image Gene #59: 'Del Peak 11(4q22.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 12(4q34.3) mutation analysis' versus 'AGE'

P value = 1.14e-05 (t-test), Q value = 0.0043

Table S91. Gene #60: 'Del Peak 12(4q34.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 12(4Q34.3) MUTATED	91	67.9 (10.0)
DEL PEAK 12(4Q34.3) WILD-TYPE	355	62.5 (11.3)

Figure S91. Get High-res Image Gene #60: 'Del Peak 12(4q34.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 12(4q34.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.59e-22 (Fisher's exact test), Q value = 1.2e-19

Table S92. Gene #60: 'Del Peak 12(4q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 12(4Q34.3) MUTATED	35	6	50
DEL PEAK 12(4Q34.3) WILD-TYPE	315	12	29

Figure S92. Get High-res Image Gene #60: 'Del Peak 12(4q34.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 13(5q11.2) mutation analysis' versus 'AGE'

P value = 6.49e-05 (t-test), Q value = 0.024

Table S93. Gene #61: 'Del Peak 13(5q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 13(5Q11.2) MUTATED	78	67.9 (9.8)
DEL PEAK 13(5Q11.2) WILD-TYPE	368	62.7 (11.3)

Figure S93. Get High-res Image Gene #61: 'Del Peak 13(5q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 13(5q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.47e-21 (Fisher's exact test), Q value = 7e-19

Table S94. Gene #61: 'Del Peak 13(5q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 13(5Q11.2) MUTATED	29	2	47
DEL PEAK 13(5Q11.2) WILD-TYPE	321	16	32

Figure S94. Get High-res Image Gene #61: 'Del Peak 13(5q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 14(6q26) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.05e-08 (Fisher's exact test), Q value = 4.4e-06

Table S95. Gene #62: 'Del Peak 14(6q26) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 14(6Q26) MUTATED	12	3	20
DEL PEAK 14(6Q26) WILD-TYPE	338	15	59

Figure S95. Get High-res Image Gene #62: 'Del Peak 14(6q26) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 15(7p22.3) mutation analysis' versus 'AGE'

P value = 2.51e-05 (t-test), Q value = 0.0093

Table S96. Gene #63: 'Del Peak 15(7p22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 15(7P22.3) MUTATED	57	68.9 (9.5)
DEL PEAK 15(7P22.3) WILD-TYPE	389	62.8 (11.3)

Figure S96. Get High-res Image Gene #63: 'Del Peak 15(7p22.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 15(7p22.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.1e-13 (Fisher's exact test), Q value = 4.9e-11

Table S97. Gene #63: 'Del Peak 15(7p22.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 15(7P22.3) MUTATED	21	5	32
DEL PEAK 15(7P22.3) WILD-TYPE	329	13	47

Figure S97. Get High-res Image Gene #63: 'Del Peak 15(7p22.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 16(7q11.22) mutation analysis' versus 'AGE'

P value = 2.09e-05 (t-test), Q value = 0.0078

Table S98. Gene #64: 'Del Peak 16(7q11.22) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 16(7Q11.22) MUTATED	31	71.0 (8.6)
DEL PEAK 16(7Q11.22) WILD-TYPE	415	63.0 (11.2)

Figure S98. Get High-res Image Gene #64: 'Del Peak 16(7q11.22) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 16(7q11.22) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 9.54e-08 (Fisher's exact test), Q value = 3.9e-05

Table S99. Gene #64: 'Del Peak 16(7q11.22) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 16(7Q11.22) MUTATED	11	2	18
DEL PEAK 16(7Q11.22) WILD-TYPE	339	16	61

Figure S99. Get High-res Image Gene #64: 'Del Peak 16(7q11.22) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 17(7q31.1) mutation analysis' versus 'AGE'

P value = 3.68e-06 (t-test), Q value = 0.0014

Table S100. Gene #65: 'Del Peak 17(7q31.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 17(7Q31.1) MUTATED	39	69.9 (7.6)
DEL PEAK 17(7Q31.1) WILD-TYPE	407	63.0 (11.4)

Figure S100. Get High-res Image Gene #65: 'Del Peak 17(7q31.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 17(7q31.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.18e-16 (Fisher's exact test), Q value = 1.9e-13

Table S101. Gene #65: 'Del Peak 17(7q31.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 17(7Q31.1) MUTATED	8	3	28
DEL PEAK 17(7Q31.1) WILD-TYPE	342	15	51

Figure S101. Get High-res Image Gene #65: 'Del Peak 17(7q31.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 18(7q36.3) mutation analysis' versus 'AGE'

P value = 4.14e-08 (t-test), Q value = 1.7e-05

Table S102. Gene #66: 'Del Peak 18(7q36.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 18(7Q36.3) MUTATED	49	70.8 (8.4)
DEL PEAK 18(7Q36.3) WILD-TYPE	397	62.7 (11.3)

Figure S102. Get High-res Image Gene #66: 'Del Peak 18(7q36.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 18(7q36.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.21e-16 (Fisher's exact test), Q value = 1e-13

Table S103. Gene #66: 'Del Peak 18(7q36.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 18(7Q36.3) MUTATED	13	5	31
DEL PEAK 18(7Q36.3) WILD-TYPE	337	13	48

Figure S103. Get High-res Image Gene #66: 'Del Peak 18(7q36.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 19(8p23.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.08e-23 (Fisher's exact test), Q value = 5.3e-21

Table S104. Gene #67: 'Del Peak 19(8p23.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 19(8P23.2) MUTATED	28	4	49
DEL PEAK 19(8P23.2) WILD-TYPE	322	14	30

Figure S104. Get High-res Image Gene #67: 'Del Peak 19(8p23.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 20(9p23) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 9.61e-11 (Fisher's exact test), Q value = 4.1e-08

Table S105. Gene #68: 'Del Peak 20(9p23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 20(9P23) MUTATED	20	3	28
DEL PEAK 20(9P23) WILD-TYPE	330	15	51

Figure S105. Get High-res Image Gene #68: 'Del Peak 20(9p23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 21(9q34.11) mutation analysis' versus 'AGE'

P value = 7.77e-10 (t-test), Q value = 3.3e-07

Table S106. Gene #69: 'Del Peak 21(9q34.11) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 21(9Q34.11) MUTATED	102	68.9 (8.9)
DEL PEAK 21(9Q34.11) WILD-TYPE	344	62.0 (11.4)

Figure S106. Get High-res Image Gene #69: 'Del Peak 21(9q34.11) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 21(9q34.11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.56e-18 (Fisher's exact test), Q value = 3.1e-15

Table S107. Gene #69: 'Del Peak 21(9q34.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 21(9Q34.11) MUTATED	46	8	48
DEL PEAK 21(9Q34.11) WILD-TYPE	304	10	31

Figure S107. Get High-res Image Gene #69: 'Del Peak 21(9q34.11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 22(10q23.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.9e-05 (Fisher's exact test), Q value = 0.0071

Table S108. Gene #70: 'Del Peak 22(10q23.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 22(10Q23.31) MUTATED	28	3	22
DEL PEAK 22(10Q23.31) WILD-TYPE	322	15	57

Figure S108. Get High-res Image Gene #70: 'Del Peak 22(10q23.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 23(11p15.5) mutation analysis' versus 'AGE'

P value = 3.06e-08 (t-test), Q value = 1.3e-05

Table S109. Gene #71: 'Del Peak 23(11p15.5) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 23(11P15.5) MUTATED	78	69.2 (8.9)
DEL PEAK 23(11P15.5) WILD-TYPE	368	62.4 (11.3)

Figure S109. Get High-res Image Gene #71: 'Del Peak 23(11p15.5) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 23(11p15.5) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.7e-21 (Fisher's exact test), Q value = 1.3e-18

Table S110. Gene #71: 'Del Peak 23(11p15.5) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 23(11P15.5) MUTATED	27	6	45
DEL PEAK 23(11P15.5) WILD-TYPE	323	12	34

Figure S110. Get High-res Image Gene #71: 'Del Peak 23(11p15.5) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 24(11q14.1) mutation analysis' versus 'AGE'

P value = 2.66e-05 (t-test), Q value = 0.0098

Table S111. Gene #72: 'Del Peak 24(11q14.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 24(11Q14.1) MUTATED	51	68.9 (8.6)
DEL PEAK 24(11Q14.1) WILD-TYPE	395	62.9 (11.4)

Figure S111. Get High-res Image Gene #72: 'Del Peak 24(11q14.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 24(11q14.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.72e-14 (Fisher's exact test), Q value = 1.7e-11

Table S112. Gene #72: 'Del Peak 24(11q14.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 24(11Q14.1) MUTATED	16	6	29
DEL PEAK 24(11Q14.1) WILD-TYPE	334	12	50

Figure S112. Get High-res Image Gene #72: 'Del Peak 24(11q14.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 25(11q25) mutation analysis' versus 'AGE'

P value = 0.000158 (t-test), Q value = 0.056

Table S113. Gene #73: 'Del Peak 25(11q25) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 25(11Q25) MUTATED	69	68.0 (9.9)
DEL PEAK 25(11Q25) WILD-TYPE	377	62.8 (11.3)

Figure S113. Get High-res Image Gene #73: 'Del Peak 25(11q25) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 25(11q25) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.29e-15 (Fisher's exact test), Q value = 2.8e-12

Table S114. Gene #73: 'Del Peak 25(11q25) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 25(11Q25) MUTATED	27	5	37
DEL PEAK 25(11Q25) WILD-TYPE	323	13	42

Figure S114. Get High-res Image Gene #73: 'Del Peak 25(11q25) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 26(12q23.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.05e-11 (Fisher's exact test), Q value = 1.7e-08

Table S115. Gene #74: 'Del Peak 26(12q23.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 26(12Q23.1) MUTATED	10	1	23
DEL PEAK 26(12Q23.1) WILD-TYPE	340	17	56

Figure S115. Get High-res Image Gene #74: 'Del Peak 26(12q23.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 27(12q24.33) mutation analysis' versus 'AGE'

P value = 0.000116 (t-test), Q value = 0.041

Table S116. Gene #75: 'Del Peak 27(12q24.33) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 27(12Q24.33) MUTATED	45	69.0 (9.1)
DEL PEAK 27(12Q24.33) WILD-TYPE	401	63.0 (11.3)

Figure S116. Get High-res Image Gene #75: 'Del Peak 27(12q24.33) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 27(12q24.33) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.36e-13 (Fisher's exact test), Q value = 1.9e-10

Table S117. Gene #75: 'Del Peak 27(12q24.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 27(12Q24.33) MUTATED	15	1	29
DEL PEAK 27(12Q24.33) WILD-TYPE	335	17	50

Figure S117. Get High-res Image Gene #75: 'Del Peak 27(12q24.33) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 28(13q11) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.87e-10 (Fisher's exact test), Q value = 3.3e-07

Table S118. Gene #76: 'Del Peak 28(13q11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 28(13Q11) MUTATED	32	3	32
DEL PEAK 28(13Q11) WILD-TYPE	318	15	47

Figure S118. Get High-res Image Gene #76: 'Del Peak 28(13q11) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 29(13q14.2) mutation analysis' versus 'AGE'

P value = 0.000327 (t-test), Q value = 0.11

Table S119. Gene #77: 'Del Peak 29(13q14.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 29(13Q14.2) MUTATED	72	67.5 (9.6)
DEL PEAK 29(13Q14.2) WILD-TYPE	374	62.8 (11.4)

Figure S119. Get High-res Image Gene #77: 'Del Peak 29(13q14.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 29(13q14.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 5.28e-05 (Fisher's exact test), Q value = 0.019

Table S120. Gene #77: 'Del Peak 29(13q14.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 29(13Q14.2) MUTATED	42	4	26
DEL PEAK 29(13Q14.2) WILD-TYPE	308	14	53

Figure S120. Get High-res Image Gene #77: 'Del Peak 29(13q14.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 30(14q13.1) mutation analysis' versus 'AGE'

P value = 0.000739 (t-test), Q value = 0.25

Table S121. Gene #78: 'Del Peak 30(14q13.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 30(14Q13.1) MUTATED	55	68.1 (10.0)
DEL PEAK 30(14Q13.1) WILD-TYPE	391	62.9 (11.3)

Figure S121. Get High-res Image Gene #78: 'Del Peak 30(14q13.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 30(14q13.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 9.68e-12 (Fisher's exact test), Q value = 4.2e-09

Table S122. Gene #78: 'Del Peak 30(14q13.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 30(14Q13.1) MUTATED	21	5	29
DEL PEAK 30(14Q13.1) WILD-TYPE	329	13	50

Figure S122. Get High-res Image Gene #78: 'Del Peak 30(14q13.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 31(15q15.1) mutation analysis' versus 'AGE'

P value = 1.44e-08 (t-test), Q value = 6e-06

Table S123. Gene #79: 'Del Peak 31(15q15.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 31(15Q15.1) MUTATED	104	68.7 (9.6)
DEL PEAK 31(15Q15.1) WILD-TYPE	342	62.0 (11.3)

Figure S123. Get High-res Image Gene #79: 'Del Peak 31(15q15.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 31(15q15.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 6.83e-21 (Fisher's exact test), Q value = 3.3e-18

Table S124. Gene #79: 'Del Peak 31(15q15.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 31(15Q15.1) MUTATED	45	7	52
DEL PEAK 31(15Q15.1) WILD-TYPE	305	11	27

Figure S124. Get High-res Image Gene #79: 'Del Peak 31(15q15.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 32(15q23) mutation analysis' versus 'AGE'

P value = 1.79e-05 (t-test), Q value = 0.0067

Table S125. Gene #80: 'Del Peak 32(15q23) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 32(15Q23) MUTATED	83	67.9 (9.5)
DEL PEAK 32(15Q23) WILD-TYPE	363	62.6 (11.4)

Figure S125. Get High-res Image Gene #80: 'Del Peak 32(15q23) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 32(15q23) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 7.29e-20 (Fisher's exact test), Q value = 3.5e-17

Table S126. Gene #80: 'Del Peak 32(15q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 32(15Q23) MUTATED	32	5	46
DEL PEAK 32(15Q23) WILD-TYPE	318	13	33

Figure S126. Get High-res Image Gene #80: 'Del Peak 32(15q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 33(16p13.3) mutation analysis' versus 'AGE'

P value = 9.74e-08 (t-test), Q value = 4e-05

Table S127. Gene #81: 'Del Peak 33(16p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 33(16P13.3) MUTATED	62	69.3 (8.0)
DEL PEAK 33(16P13.3) WILD-TYPE	384	62.6 (11.4)

Figure S127. Get High-res Image Gene #81: 'Del Peak 33(16p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 33(16p13.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.02e-15 (Fisher's exact test), Q value = 4.7e-13

Table S128. Gene #81: 'Del Peak 33(16p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 33(16P13.3) MUTATED	22	4	36
DEL PEAK 33(16P13.3) WILD-TYPE	328	14	43

Figure S128. Get High-res Image Gene #81: 'Del Peak 33(16p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 34(16q21) mutation analysis' versus 'AGE'

P value = 7.63e-09 (t-test), Q value = 3.2e-06

Table S129. Gene #82: 'Del Peak 34(16q21) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 34(16Q21) MUTATED	117	68.2 (9.2)
DEL PEAK 34(16Q21) WILD-TYPE	329	61.9 (11.5)

Figure S129. Get High-res Image Gene #82: 'Del Peak 34(16q21) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 34(16q21) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.85e-21 (Fisher's exact test), Q value = 8.9e-19

Table S130. Gene #82: 'Del Peak 34(16q21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 34(16Q21) MUTATED	54	7	56
DEL PEAK 34(16Q21) WILD-TYPE	296	11	23

Figure S130. Get High-res Image Gene #82: 'Del Peak 34(16q21) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 35(16q23.1) mutation analysis' versus 'AGE'

P value = 5.24e-08 (t-test), Q value = 2.1e-05

Table S131. Gene #83: 'Del Peak 35(16q23.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 35(16Q23.1) MUTATED	127	67.8 (9.4)
DEL PEAK 35(16Q23.1) WILD-TYPE	319	61.9 (11.5)

Figure S131. Get High-res Image Gene #83: 'Del Peak 35(16q23.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 35(16q23.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.42e-25 (Fisher's exact test), Q value = 1.7e-22

Table S132. Gene #83: 'Del Peak 35(16q23.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 35(16Q23.1) MUTATED	59	6	62
DEL PEAK 35(16Q23.1) WILD-TYPE	291	12	17

Figure S132. Get High-res Image Gene #83: 'Del Peak 35(16q23.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 36(17p13.3) mutation analysis' versus 'AGE'

P value = 8.02e-05 (t-test), Q value = 0.029

Table S133. Gene #84: 'Del Peak 36(17p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 36(17P13.3) MUTATED	85	67.4 (9.2)
DEL PEAK 36(17P13.3) WILD-TYPE	361	62.7 (11.5)

Figure S133. Get High-res Image Gene #84: 'Del Peak 36(17p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 36(17p13.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.59e-17 (Fisher's exact test), Q value = 2.1e-14

Table S134. Gene #84: 'Del Peak 36(17p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 36(17P13.3) MUTATED	35	8	42
DEL PEAK 36(17P13.3) WILD-TYPE	315	10	37

Figure S134. Get High-res Image Gene #84: 'Del Peak 36(17p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 37(17p12) mutation analysis' versus 'AGE'

P value = 1.56e-07 (t-test), Q value = 6.2e-05

Table S135. Gene #85: 'Del Peak 37(17p12) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 37(17P12) MUTATED	97	68.3 (9.1)
DEL PEAK 37(17P12) WILD-TYPE	349	62.3 (11.5)

Figure S135. Get High-res Image Gene #85: 'Del Peak 37(17p12) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 37(17p12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.91e-24 (Fisher's exact test), Q value = 2.4e-21

Table S136. Gene #85: 'Del Peak 37(17p12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 37(17P12) MUTATED	37	8	52
DEL PEAK 37(17P12) WILD-TYPE	313	10	27

Figure S136. Get High-res Image Gene #85: 'Del Peak 37(17p12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 38(17p11.2) mutation analysis' versus 'AGE'

P value = 1.86e-06 (t-test), Q value = 0.00072

Table S137. Gene #86: 'Del Peak 38(17p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 38(17P11.2) MUTATED	88	68.2 (9.2)
DEL PEAK 38(17P11.2) WILD-TYPE	358	62.4 (11.4)

Figure S137. Get High-res Image Gene #86: 'Del Peak 38(17p11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 38(17p11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.42e-17 (Fisher's exact test), Q value = 1.1e-14

Table S138. Gene #86: 'Del Peak 38(17p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 38(17P11.2) MUTATED	37	7	44
DEL PEAK 38(17P11.2) WILD-TYPE	313	11	35

Figure S138. Get High-res Image Gene #86: 'Del Peak 38(17p11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 39(17q11.2) mutation analysis' versus 'AGE'

P value = 8.22e-06 (t-test), Q value = 0.0031

Table S139. Gene #87: 'Del Peak 39(17q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 39(17Q11.2) MUTATED	78	68.2 (9.3)
DEL PEAK 39(17Q11.2) WILD-TYPE	368	62.6 (11.4)

Figure S139. Get High-res Image Gene #87: 'Del Peak 39(17q11.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 39(17q11.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.73e-10 (Fisher's exact test), Q value = 7.4e-08

Table S140. Gene #87: 'Del Peak 39(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 39(17Q11.2) MUTATED	38	5	35
DEL PEAK 39(17Q11.2) WILD-TYPE	312	13	44

Figure S140. Get High-res Image Gene #87: 'Del Peak 39(17q11.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 40(17q21.2) mutation analysis' versus 'AGE'

P value = 1.11e-05 (t-test), Q value = 0.0042

Table S141. Gene #88: 'Del Peak 40(17q21.2) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 40(17Q21.2) MUTATED	83	68.1 (9.6)
DEL PEAK 40(17Q21.2) WILD-TYPE	363	62.5 (11.4)

Figure S141. Get High-res Image Gene #88: 'Del Peak 40(17q21.2) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 40(17q21.2) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.62e-14 (Fisher's exact test), Q value = 2.1e-11

Table S142. Gene #88: 'Del Peak 40(17q21.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 40(17Q21.2) MUTATED	37	6	40
DEL PEAK 40(17Q21.2) WILD-TYPE	313	12	39

Figure S142. Get High-res Image Gene #88: 'Del Peak 40(17q21.2) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 41(18q23) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.3e-14 (Fisher's exact test), Q value = 5.9e-12

Table S143. Gene #89: 'Del Peak 41(18q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 41(18Q23) MUTATED	30	5	38
DEL PEAK 41(18Q23) WILD-TYPE	320	13	41

Figure S143. Get High-res Image Gene #89: 'Del Peak 41(18q23) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 42(19p13.3) mutation analysis' versus 'AGE'

P value = 1.81e-11 (t-test), Q value = 7.8e-09

Table S144. Gene #90: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 42(19P13.3) MUTATED	116	68.9 (8.7)
DEL PEAK 42(19P13.3) WILD-TYPE	330	61.7 (11.5)

Figure S144. Get High-res Image Gene #90: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 42(19p13.3) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 3.19e-46 (Fisher's exact test), Q value = 1.6e-43

Table S145. Gene #90: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 42(19P13.3) MUTATED	36	8	72
DEL PEAK 42(19P13.3) WILD-TYPE	314	10	7

Figure S145. Get High-res Image Gene #90: 'Del Peak 42(19p13.3) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 43(19p12) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.35e-07 (Fisher's exact test), Q value = 5.5e-05

Table S146. Gene #91: 'Del Peak 43(19p12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 43(19P12) MUTATED	15	4	19
DEL PEAK 43(19P12) WILD-TYPE	335	14	60

Figure S146. Get High-res Image Gene #91: 'Del Peak 43(19p12) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 44(19q13.43) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.08e-14 (Fisher's exact test), Q value = 4.9e-12

Table S147. Gene #92: 'Del Peak 44(19q13.43) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 44(19Q13.43) MUTATED	14	4	30
DEL PEAK 44(19Q13.43) WILD-TYPE	336	14	49

Figure S147. Get High-res Image Gene #92: 'Del Peak 44(19q13.43) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 46(22q11.1) mutation analysis' versus 'AGE'

P value = 9.75e-05 (t-test), Q value = 0.035

Table S148. Gene #94: 'Del Peak 46(22q11.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 46(22Q11.1) MUTATED	66	67.8 (8.9)
DEL PEAK 46(22Q11.1) WILD-TYPE	380	62.8 (11.5)

Figure S148. Get High-res Image Gene #94: 'Del Peak 46(22q11.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 46(22q11.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.25e-05 (Fisher's exact test), Q value = 0.0047

Table S149. Gene #94: 'Del Peak 46(22q11.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 46(22Q11.1) MUTATED	37	3	26
DEL PEAK 46(22Q11.1) WILD-TYPE	313	15	53

Figure S149. Get High-res Image Gene #94: 'Del Peak 46(22q11.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 47(22q12.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 2.09e-06 (Fisher's exact test), Q value = 0.00081

Table S150. Gene #95: 'Del Peak 47(22q12.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 47(22Q12.1) MUTATED	38	7	25
DEL PEAK 47(22Q12.1) WILD-TYPE	312	11	54

Figure S150. Get High-res Image Gene #95: 'Del Peak 47(22q12.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 48(22q13.31) mutation analysis' versus 'AGE'

P value = 2.37e-08 (t-test), Q value = 9.8e-06

Table S151. Gene #96: 'Del Peak 48(22q13.31) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 48(22Q13.31) MUTATED	99	68.7 (9.4)
DEL PEAK 48(22Q13.31) WILD-TYPE	347	62.1 (11.3)

Figure S151. Get High-res Image Gene #96: 'Del Peak 48(22q13.31) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 48(22q13.31) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.51e-17 (Fisher's exact test), Q value = 2.1e-14

Table S152. Gene #96: 'Del Peak 48(22q13.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 48(22Q13.31) MUTATED	45	7	47
DEL PEAK 48(22Q13.31) WILD-TYPE	305	11	32

Figure S152. Get High-res Image Gene #96: 'Del Peak 48(22q13.31) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 49(22q13.32) mutation analysis' versus 'AGE'

P value = 5.33e-07 (t-test), Q value = 0.00021

Table S153. Gene #97: 'Del Peak 49(22q13.32) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 49(22Q13.32) MUTATED	105	68.2 (10.1)
DEL PEAK 49(22Q13.32) WILD-TYPE	341	62.2 (11.2)

Figure S153. Get High-res Image Gene #97: 'Del Peak 49(22q13.32) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 49(22q13.32) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 4.69e-18 (Fisher's exact test), Q value = 2.2e-15

Table S154. Gene #97: 'Del Peak 49(22q13.32) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 49(22Q13.32) MUTATED	48	8	49
DEL PEAK 49(22Q13.32) WILD-TYPE	302	10	30

Figure S154. Get High-res Image Gene #97: 'Del Peak 49(22q13.32) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

'Del Peak 50(Xp21.1) mutation analysis' versus 'AGE'

P value = 0.000158 (t-test), Q value = 0.056

Table S155. Gene #98: 'Del Peak 50(Xp21.1) mutation analysis' versus Clinical Feature #2: 'AGE'

	nPatients	Mean (Std.Dev)
ALL	446	63.6 (11.3)
DEL PEAK 50(XP21.1) MUTATED	62	67.8 (8.8)
DEL PEAK 50(XP21.1) WILD-TYPE	384	62.9 (11.5)

Figure S155. Get High-res Image Gene #98: 'Del Peak 50(Xp21.1) mutation analysis' versus Clinical Feature #2: 'AGE'

'Del Peak 50(Xp21.1) mutation analysis' versus 'HISTOLOGICAL.TYPE'

P value = 1.32e-12 (Fisher's exact test), Q value = 5.8e-10

Table S156. Gene #98: 'Del Peak 50(Xp21.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

nPatients	ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA	MIXED SEROUS AND ENDOMETRIOID	SEROUS ENDOMETRIAL ADENOCARCINOMA
ALL	350	18	79
DEL PEAK 50(XP21.1) MUTATED	26	2	34
DEL PEAK 50(XP21.1) WILD-TYPE	324	16	45

Figure S156. Get High-res Image Gene #98: 'Del Peak 50(Xp21.1) mutation analysis' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'

Methods & Data

Input

Mutation data file = all_lesions.conf_99.cnv.cluster.txt
Clinical data file = UCEC-TP.clin.merged.picked.txt
Number of patients = 447
Number of significantly arm-level cnvs = 98
Number of selected clinical features = 5
Exclude genes that fewer than K tumors have mutations, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Student's t-test analysis

For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between tumors with and without gene mutations using 't.test' function in R

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.

References

[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)

[2] Lehmann and Romano, Testing Statistical Hypotheses (3E ed.), New York: Springer. ISBN 0387988645 (2005)

[3] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)

[4] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)

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