Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.168 0.228 -9999.0 0.0 -0.574 10.0 10.0 IHH -0.239 0.212 -9999.0 0.0 -0.398 33.0 33.0 SHH Np/Cholesterol/GAS1 -0.075 0.119 -9999.0 0.0 -0.194 25.0 25.0 LRPAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.074 0.118 0.192 25.0 -9999.0 0.0 25.0 SMO/beta Arrestin2 -0.158 0.205 -9999.0 0.0 -0.445 13.0 13.0 SMO -0.173 0.214 -9999.0 0.0 -0.473 13.0 13.0 AKT1 -0.096 0.166 -9999.0 0.0 -0.661 3.0 3.0 ARRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.03 0.113 -9999.0 0.0 -0.3 8.0 8.0 ADRBK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.171 0.211 -9999.0 0.0 -0.466 13.0 13.0 STIL -0.125 0.163 -9999.0 0.0 -0.354 14.0 14.0 DHH N/PTCH2 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.12 0.152 -9999.0 0.0 -0.368 10.0 10.0 PIK3CA 0.01 0.058 -9999.0 0.0 -0.411 1.0 1.0 DHH 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.2 0.266 -9999.0 0.0 -0.654 10.0 10.0 determination of left/right symmetry -0.171 0.211 -9999.0 0.0 -0.466 13.0 13.0 PIK3R1 -0.038 0.134 -9999.0 0.0 -0.355 8.0 8.0 skeletal system development -0.199 0.263 -9999.0 0.0 -0.648 10.0 10.0 IHH N/Hhip -0.182 0.158 -9999.0 0.0 -0.304 29.0 29.0 DHH N/Hhip -0.032 0.111 -9999.0 0.0 -0.237 12.0 12.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.171 0.211 -9999.0 0.0 -0.466 13.0 13.0 pancreas development -0.065 0.157 -9999.0 0.0 -0.355 12.0 12.0 HHAT -0.052 0.156 -9999.0 0.0 -0.398 9.0 9.0 PI3K -0.018 0.112 -9999.0 0.0 -0.268 8.0 8.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.107 0.179 -9999.0 0.0 -0.355 18.0 18.0 somite specification -0.171 0.211 -9999.0 0.0 -0.466 13.0 13.0 SHH Np/Cholesterol/PTCH1 -0.131 0.164 -9999.0 0.0 -0.366 13.0 13.0 SHH Np/Cholesterol/PTCH2 -0.01 0.084 -9999.0 0.0 -0.204 8.0 8.0 SHH Np/Cholesterol/Megalin -0.021 0.096 -9999.0 0.0 -0.222 8.0 8.0 SHH -0.026 0.11 -9999.0 0.0 -0.27 9.0 9.0 catabolic process -0.145 0.17 -9999.0 0.0 -0.42 10.0 10.0 SMO/Vitamin D3 -0.153 0.195 -9999.0 0.0 -0.429 13.0 13.0 SHH Np/Cholesterol/Hhip -0.053 0.112 -9999.0 0.0 -0.22 13.0 13.0 LRP2 -0.006 0.083 -9999.0 0.0 -0.3 4.0 4.0 receptor-mediated endocytosis -0.144 0.189 -9999.0 0.0 -0.432 11.0 11.0 SHH Np/Cholesterol/BOC -0.033 0.11 -9999.0 0.0 -0.258 8.0 8.0 SHH Np/Cholesterol/CDO -0.021 0.096 -9999.0 0.0 -0.222 8.0 8.0 mesenchymal cell differentiation 0.053 0.111 0.219 13.0 -9999.0 0.0 13.0 mol:Vitamin D3 -0.131 0.165 -9999.0 0.0 -0.369 13.0 13.0 IHH N/PTCH2 -0.123 0.126 -9999.0 0.0 -0.254 22.0 22.0 CDON -0.006 0.083 -9999.0 0.0 -0.3 4.0 4.0 IHH N/PTCH1 -0.145 0.173 -9999.0 0.0 -0.424 10.0 10.0 Megalin/LRPAP1 0.01 0.058 -9999.0 0.0 -0.194 4.0 4.0 PTCH2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.019 0.083 -9999.0 0.0 -0.203 9.0 9.0 PTCH1 -0.145 0.17 -9999.0 0.0 -0.421 10.0 10.0 HHIP -0.065 0.157 -9999.0 0.0 -0.355 12.0 12.0