Pathway Name Avg Num Perturbations Total Perturbations Num Entities Min Mean Truth Max Mean Truth Min Mean Within Max Mean Within Min Mean Any Max Mean Within Ephrin B reverse signaling 8.0 402.0 48.0 -0.222 0.028 1000.0 -1000.0 -0.015 -1000.0 Signaling events mediated by the Hedgehog family 7.0 403.0 52.0 -0.124 0.04 1000.0 -1000.0 -0.017 -1000.0 FOXM1 transcription factor network 7.0 373.0 51.0 -0.433 0.027 1000.0 -1000.0 -0.043 -1000.0 Signaling events mediated by Stem cell factor receptor (c-Kit) 7.0 576.0 78.0 -0.231 0.087 1000.0 -1000.0 -0.033 -1000.0 PLK2 and PLK4 events 6.0 20.0 3.0 -0.047 0.02 1000.0 -1000.0 -0.004 -1000.0 HIF-1-alpha transcription factor network 6.0 493.0 76.0 -0.191 0.031 1000.0 -1000.0 -0.024 -1000.0 Plasma membrane estrogen receptor signaling 6.0 523.0 86.0 -0.167 0.157 1000.0 -1000.0 -0.032 -1000.0 Osteopontin-mediated events 5.0 192.0 38.0 -0.095 0.028 1000.0 -1000.0 -0.02 -1000.0 Noncanonical Wnt signaling pathway 5.0 140.0 26.0 -0.071 0.027 1000.0 -1000.0 -0.02 -1000.0 Glypican 1 network 5.0 278.0 48.0 -0.058 0.03 1000.0 -1000.0 -0.017 -1000.0 Nectin adhesion pathway 5.0 343.0 63.0 -0.082 0.057 1000.0 -1000.0 -0.037 -1000.0 Endothelins 5.0 519.0 96.0 -0.149 0.033 1000.0 -1000.0 -0.029 -1000.0 Calcineurin-regulated NFAT-dependent transcription in lymphocytes 5.0 380.0 68.0 -0.205 0.117 1000.0 -1000.0 -0.057 -1000.0 TCGA08_retinoblastoma 5.0 47.0 8.0 -0.036 0.023 1000.0 -1000.0 -0.001 -1000.0 IGF1 pathway 5.0 336.0 57.0 -0.063 0.046 1000.0 -1000.0 -0.03 -1000.0 IL12-mediated signaling events 4.0 366.0 87.0 -0.26 0.048 1000.0 -1000.0 -0.043 -1000.0 IL4-mediated signaling events 4.0 403.0 91.0 -0.554 0.356 1000.0 -1000.0 -0.086 -1000.0 Signaling mediated by p38-alpha and p38-beta 4.0 179.0 44.0 -0.067 0.028 1000.0 -1000.0 -0.015 -1000.0 Wnt signaling 4.0 32.0 7.0 -0.065 0.024 1000.0 -1000.0 -0.006 -1000.0 IL23-mediated signaling events 4.0 298.0 60.0 -0.306 0.028 1000.0 -1000.0 -0.059 -1000.0 Regulation of nuclear SMAD2/3 signaling 3.0 480.0 136.0 -0.412 0.074 1000.0 -1000.0 -0.033 -1000.0 Syndecan-1-mediated signaling events 3.0 110.0 34.0 -0.079 0.037 1000.0 -1000.0 -0.019 -1000.0 Thromboxane A2 receptor signaling 3.0 331.0 105.0 -0.075 0.05 1000.0 -1000.0 -0.026 -1000.0 BMP receptor signaling 3.0 262.0 81.0 -0.1 0.047 1000.0 -1000.0 -0.018 -1000.0 Fc-epsilon receptor I signaling in mast cells 3.0 312.0 97.0 -0.064 0.046 1000.0 -1000.0 -0.033 -1000.0 Reelin signaling pathway 3.0 181.0 56.0 -0.049 0.05 1000.0 -1000.0 -0.019 -1000.0 TCGA08_p53 3.0 21.0 7.0 -0.035 0.022 1000.0 -1000.0 -0.002 -1000.0 FAS signaling pathway (CD95) 3.0 177.0 47.0 -0.083 0.034 1000.0 -1000.0 -0.024 -1000.0 EPHB forward signaling 3.0 321.0 85.0 -0.072 0.047 1000.0 -1000.0 -0.043 -1000.0 Glypican 2 network 3.0 15.0 4.0 -0.01 0.0 1000.0 -1000.0 -0.0 -1000.0 Nongenotropic Androgen signaling 3.0 184.0 52.0 -0.1 0.048 1000.0 -1000.0 -0.017 -1000.0 IL27-mediated signaling events 3.0 153.0 51.0 -0.094 0.047 1000.0 -1000.0 -0.036 -1000.0 LPA receptor mediated events 3.0 326.0 102.0 -0.104 0.028 1000.0 -1000.0 -0.053 -1000.0 Syndecan-4-mediated signaling events 3.0 213.0 67.0 -0.06 0.038 1000.0 -1000.0 -0.025 -1000.0 VEGFR1 specific signals 3.0 209.0 56.0 -0.048 0.028 1000.0 -1000.0 -0.023 -1000.0 Regulation of Androgen receptor activity 3.0 221.0 70.0 -0.143 0.034 1000.0 -1000.0 -0.035 -1000.0 Caspase cascade in apoptosis 2.0 221.0 74.0 -0.036 0.038 1000.0 -1000.0 -0.028 -1000.0 Coregulation of Androgen receptor activity 2.0 222.0 76.0 -0.133 0.047 1000.0 -1000.0 -0.016 -1000.0 Visual signal transduction: Cones 2.0 82.0 38.0 -0.014 0.043 1000.0 -1000.0 -0.002 -1000.0 JNK signaling in the CD4+ TCR pathway 2.0 35.0 17.0 -0.032 0.048 1000.0 -1000.0 -0.015 -1000.0 Syndecan-2-mediated signaling events 2.0 146.0 69.0 -0.035 0.04 1000.0 -1000.0 -0.024 -1000.0 Cellular roles of Anthrax toxin 2.0 108.0 39.0 -0.056 0.027 1000.0 -1000.0 -0.014 -1000.0 Arf6 signaling events 2.0 127.0 62.0 -0.009 0.043 1000.0 -1000.0 -0.003 -1000.0 Signaling events mediated by PTP1B 2.0 184.0 76.0 -0.07 0.047 1000.0 -1000.0 -0.027 -1000.0 Hedgehog signaling events mediated by Gli proteins 2.0 182.0 65.0 -0.317 0.066 1000.0 -1000.0 -0.035 -1000.0 Presenilin action in Notch and Wnt signaling 2.0 161.0 61.0 -0.083 0.051 1000.0 -1000.0 -0.035 -1000.0 FOXA2 and FOXA3 transcription factor networks 2.0 133.0 46.0 -0.169 0.038 1000.0 -1000.0 -0.057 -1000.0 PLK1 signaling events 2.0 205.0 85.0 -0.044 0.029 1000.0 -1000.0 -0.018 -1000.0 PDGFR-alpha signaling pathway 2.0 114.0 44.0 -0.131 0.038 1000.0 -1000.0 -0.037 -1000.0 mTOR signaling pathway 2.0 116.0 53.0 -0.019 0.034 1000.0 -1000.0 -0.023 -1000.0 IFN-gamma pathway 2.0 187.0 68.0 -0.049 0.039 1000.0 -1000.0 -0.026 -1000.0 Glucocorticoid receptor regulatory network 2.0 230.0 114.0 -0.13 0.072 1000.0 -1000.0 -0.043 -1000.0 TRAIL signaling pathway 2.0 107.0 48.0 -0.014 0.037 1000.0 -1000.0 -0.022 -1000.0 IL1-mediated signaling events 2.0 165.0 62.0 -0.042 0.043 1000.0 -1000.0 -0.023 -1000.0 ceramide signaling pathway 2.0 124.0 49.0 -0.025 0.04 1000.0 -1000.0 -0.021 -1000.0 HIF-2-alpha transcription factor network 2.0 103.0 43.0 -0.049 0.049 1000.0 -1000.0 -0.038 -1000.0 S1P1 pathway 2.0 92.0 36.0 -0.102 0.026 1000.0 -1000.0 -0.025 -1000.0 Signaling mediated by p38-gamma and p38-delta 2.0 37.0 15.0 -0.025 0.026 1000.0 -1000.0 -0.024 -1000.0 Retinoic acid receptors-mediated signaling 2.0 153.0 58.0 -0.105 0.054 1000.0 -1000.0 -0.033 -1000.0 Syndecan-3-mediated signaling events 2.0 72.0 35.0 -0.055 0.05 1000.0 -1000.0 -0.012 -1000.0 IL2 signaling events mediated by PI3K 2.0 126.0 58.0 -0.1 0.028 1000.0 -1000.0 -0.03 -1000.0 Integrins in angiogenesis 2.0 216.0 84.0 -0.075 0.055 1000.0 -1000.0 -0.025 -1000.0 TCR signaling in naïve CD8+ T cells 2.0 278.0 93.0 -0.057 0.037 1000.0 -1000.0 -0.032 -1000.0 HIV-1 Nef: Negative effector of Fas and TNF-alpha 2.0 128.0 45.0 -0.031 0.048 1000.0 -1000.0 -0.03 -1000.0 Canonical Wnt signaling pathway 2.0 143.0 51.0 -0.083 0.067 1000.0 -1000.0 -0.028 -1000.0 IL6-mediated signaling events 2.0 199.0 75.0 -0.077 0.073 1000.0 -1000.0 -0.036 -1000.0 Stabilization and expansion of the E-cadherin adherens junction 2.0 166.0 74.0 -0.054 0.049 1000.0 -1000.0 -0.043 -1000.0 Class I PI3K signaling events 2.0 151.0 73.0 -0.029 0.045 1000.0 -1000.0 -0.02 -1000.0 BCR signaling pathway 2.0 245.0 99.0 -0.048 0.053 1000.0 -1000.0 -0.035 -1000.0 Visual signal transduction: Rods 2.0 109.0 52.0 -0.076 0.061 1000.0 -1000.0 -0.018 -1000.0 E-cadherin signaling in keratinocytes 2.0 102.0 43.0 -0.032 0.041 1000.0 -1000.0 -0.021 -1000.0 S1P4 pathway 2.0 54.0 25.0 -0.026 0.038 1000.0 -1000.0 -0.012 -1000.0 Ras signaling in the CD4+ TCR pathway 2.0 37.0 17.0 -0.014 0.043 1000.0 -1000.0 -0.015 -1000.0 Aurora B signaling 2.0 160.0 67.0 -0.073 0.043 1000.0 -1000.0 -0.025 -1000.0 LPA4-mediated signaling events 1.0 20.0 12.0 -0.023 0.002 1000.0 -1000.0 -0.018 -1000.0 ErbB2/ErbB3 signaling events 1.0 76.0 65.0 -0.038 0.067 1000.0 -1000.0 -0.038 -1000.0 Regulation of cytoplasmic and nuclear SMAD2/3 signaling 1.0 25.0 23.0 -0.003 0.037 1000.0 -1000.0 -0.013 -1000.0 Nephrin/Neph1 signaling in the kidney podocyte 1.0 61.0 34.0 -0.023 0.059 1000.0 -1000.0 -0.018 -1000.0 Canonical NF-kappaB pathway 1.0 41.0 39.0 -0.017 0.063 1000.0 -1000.0 -0.016 -1000.0 BARD1 signaling events 1.0 57.0 57.0 -0.049 0.065 1000.0 -1000.0 -0.029 -1000.0 Sphingosine 1-phosphate (S1P) pathway 1.0 31.0 28.0 -0.024 0.038 1000.0 -1000.0 -0.011 -1000.0 Lissencephaly gene (LIS1) in neuronal migration and development 1.0 81.0 54.0 -0.034 0.039 1000.0 -1000.0 -0.019 -1000.0 Ephrin A reverse signaling 1.0 8.0 7.0 -0.0 0.032 1000.0 -1000.0 -0.0 -1000.0 a4b1 and a4b7 Integrin signaling 1.0 7.0 5.0 0.011 0.026 1000.0 -1000.0 0.016 -1000.0 Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 1.0 126.0 85.0 -0.129 0.051 1000.0 -1000.0 -0.038 -1000.0 Aurora A signaling 1.0 94.0 60.0 -0.022 0.047 1000.0 -1000.0 -0.011 -1000.0 p75(NTR)-mediated signaling 1.0 225.0 125.0 -0.085 0.061 1000.0 -1000.0 -0.042 -1000.0 EPO signaling pathway 1.0 87.0 55.0 -0.075 0.048 1000.0 -1000.0 -0.019 -1000.0 amb2 Integrin signaling 1.0 151.0 82.0 -0.025 0.063 1000.0 -1000.0 -0.021 -1000.0 Ceramide signaling pathway 1.0 139.0 76.0 -0.045 0.063 1000.0 -1000.0 -0.021 -1000.0 Paxillin-independent events mediated by a4b1 and a4b7 1.0 64.0 37.0 -0.023 0.046 1000.0 -1000.0 -0.015 -1000.0 Signaling events mediated by HDAC Class III 1.0 71.0 40.0 -0.051 0.052 1000.0 -1000.0 -0.031 -1000.0 Signaling events regulated by Ret tyrosine kinase 1.0 91.0 82.0 -0.018 0.048 1000.0 -1000.0 -0.035 -1000.0 S1P5 pathway 1.0 30.0 17.0 -0.024 0.027 1000.0 -1000.0 -0.003 -1000.0 RXR and RAR heterodimerization with other nuclear receptor 1.0 97.0 52.0 -0.052 0.064 1000.0 -1000.0 -0.03 -1000.0 Role of Calcineurin-dependent NFAT signaling in lymphocytes 1.0 122.0 83.0 -0.026 0.056 1000.0 -1000.0 -0.014 -1000.0 FoxO family signaling 1.0 78.0 64.0 -0.037 0.041 1000.0 -1000.0 -0.036 -1000.0 Paxillin-dependent events mediated by a4b1 1.0 57.0 36.0 -0.034 0.041 1000.0 -1000.0 -0.019 -1000.0 Regulation of p38-alpha and p38-beta 1.0 64.0 54.0 -0.045 0.058 1000.0 -1000.0 -0.035 -1000.0 Calcium signaling in the CD4+ TCR pathway 1.0 42.0 31.0 -0.027 0.034 1000.0 -1000.0 -0.029 -1000.0 TCGA08_rtk_signaling 1.0 41.0 26.0 -0.056 0.064 1000.0 -1000.0 -0.006 -1000.0 E-cadherin signaling in the nascent adherens junction 1.0 145.0 76.0 -0.026 0.053 1000.0 -1000.0 -0.043 -1000.0 IL2 signaling events mediated by STAT5 1.0 39.0 22.0 -0.067 0.035 1000.0 -1000.0 -0.022 -1000.0 Regulation of Telomerase 1.0 125.0 102.0 -0.065 0.056 1000.0 -1000.0 -0.03 -1000.0 EGFR-dependent Endothelin signaling events 1.0 30.0 21.0 -0.015 0.041 1000.0 -1000.0 -0.027 -1000.0 Insulin Pathway 1.0 117.0 74.0 -0.042 0.058 1000.0 -1000.0 -0.028 -1000.0 S1P3 pathway 1.0 64.0 42.0 -0.03 0.038 1000.0 -1000.0 -0.019 -1000.0 Neurotrophic factor-mediated Trk receptor signaling 1.0 168.0 120.0 -0.046 0.075 1000.0 -1000.0 -0.028 -1000.0 PDGFR-beta signaling pathway 1.0 148.0 97.0 -0.025 0.061 1000.0 -1000.0 -0.029 -1000.0 E-cadherin signaling events 1.0 6.0 5.0 0.014 0.041 1000.0 -1000.0 0.015 -1000.0 p38 MAPK signaling pathway 1.0 53.0 44.0 -0.032 0.048 1000.0 -1000.0 -0.008 -1000.0 Signaling events mediated by HDAC Class II 0.0 63.0 75.0 -0.065 0.069 1000.0 -1000.0 -0.023 -1000.0 ErbB4 signaling events 0.0 37.0 69.0 -0.031 0.056 1000.0 -1000.0 -0.017 -1000.0 Circadian rhythm pathway 0.0 6.0 22.0 -0.01 0.058 1000.0 -1000.0 -0.026 -1000.0 Arf6 downstream pathway 0.0 31.0 43.0 -0.041 0.045 1000.0 -1000.0 -0.021 -1000.0 Aurora C signaling 0.0 5.0 7.0 -0.0 0.037 1000.0 -1000.0 -0.009 -1000.0 Insulin-mediated glucose transport 0.0 24.0 32.0 -0.002 0.05 1000.0 -1000.0 -0.015 -1000.0 Class I PI3K signaling events mediated by Akt 0.0 60.0 68.0 -0.039 0.047 1000.0 -1000.0 -0.023 -1000.0 Signaling events mediated by HDAC Class I 0.0 80.0 104.0 -0.037 0.064 1000.0 -1000.0 -0.028 -1000.0 Atypical NF-kappaB pathway 0.0 29.0 31.0 -0.007 0.028 1000.0 -1000.0 -0.011 -1000.0 Effects of Botulinum toxin 0.0 10.0 26.0 -0.001 0.046 1000.0 -1000.0 -0.002 -1000.0 Signaling events mediated by VEGFR1 and VEGFR2 0.0 121.0 125.0 -0.031 0.045 1000.0 -1000.0 -0.028 -1000.0 Sumoylation by RanBP2 regulates transcriptional repression 0.0 17.0 27.0 -0.0 0.064 1000.0 -1000.0 -0.018 -1000.0 Arf6 trafficking events 0.0 22.0 71.0 -0.039 0.049 1000.0 -1000.0 -0.021 -1000.0 Angiopoietin receptor Tie2-mediated signaling 0.0 87.0 88.0 -0.042 0.046 1000.0 -1000.0 -0.047 -1000.0 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 0.0 24.0 33.0 -0.042 0.066 1000.0 -1000.0 -0.024 -1000.0 Rapid glucocorticoid signaling 0.0 8.0 20.0 -0.003 0.034 1000.0 -1000.0 -0.003 -1000.0 Signaling events mediated by PRL 0.0 27.0 34.0 -0.031 0.041 1000.0 -1000.0 -0.035 -1000.0 Class IB PI3K non-lipid kinase events 0.0 0.0 3.0 -0.027 0.027 1000.0 -1000.0 -0.016 -1000.0 Arf1 pathway 0.0 21.0 54.0 -0.001 0.05 1000.0 -1000.0 -0.009 -1000.0 Alternative NF-kappaB pathway 0.0 3.0 13.0 0.0 0.067 1000.0 -1000.0 0.0 -1000.0 Total 268 18795 7203 -9.23453593802 6.35135845623 131000 -131000 -3.1085708891 -131000