Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.021 0.041 -9999.0 0.0 -0.238 9.0 9.0 epithelial cell differentiation 0.02 0.042 -9999.0 0.0 -0.265 8.0 8.0 CYFIP2 -0.001 0.085 -9999.0 0.0 -0.538 9.0 9.0 ENAH 0.036 0.063 -9999.0 0.0 -0.341 4.0 4.0 EGFR -0.004 0.092 -9999.0 0.0 -0.53 11.0 11.0 EPHA2 -0.003 0.088 -9999.0 0.0 -0.506 11.0 11.0 MYO6 0.022 0.058 -9999.0 0.0 -0.385 4.0 4.0 CTNNB1 0.011 0.029 -9999.0 0.0 -0.538 1.0 1.0 ABI1/Sra1/Nap1 0.017 0.053 -9999.0 0.0 -0.32 9.0 9.0 AQP5 -0.079 0.171 -9999.0 0.0 -0.461 59.0 59.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.025 0.04 -9999.0 0.0 -0.245 8.0 8.0 regulation of calcium-dependent cell-cell adhesion 0.001 0.09 -9999.0 0.0 -0.267 27.0 27.0 EGF -0.065 0.18 -9999.0 0.0 -0.485 57.0 57.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.038 0.125 -9999.0 0.0 -0.489 24.0 24.0 cortical microtubule organization 0.02 0.042 -9999.0 0.0 -0.265 8.0 8.0 GO:0000145 0.023 0.038 -9999.0 0.0 -0.234 8.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.023 0.043 -9999.0 0.0 -0.268 8.0 8.0 MLLT4 0.011 0.029 -9999.0 0.0 -0.538 1.0 1.0 ARF6/GDP -0.015 0.056 -9999.0 0.0 -0.435 2.0 2.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.016 0.068 -9999.0 0.0 -0.285 14.0 14.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.033 0.041 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.011 0.029 -9999.0 0.0 -0.538 1.0 1.0 ZYX 0.025 0.041 -9999.0 0.0 -0.248 8.0 8.0 ARF6/GTP 0.02 0.063 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.002 0.075 -9999.0 0.0 -0.538 7.0 7.0 EGFR/EGFR/EGF/EGF -0.044 0.097 -9999.0 0.0 -0.455 6.0 6.0 RhoA/GDP -0.005 0.036 -9999.0 0.0 -0.246 8.0 8.0 actin cytoskeleton organization 0.026 0.055 -9999.0 0.0 -0.486 2.0 2.0 IGF-1R heterotetramer -0.029 0.145 -9999.0 0.0 -0.537 28.0 28.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.029 0.146 -9999.0 0.0 -0.538 28.0 28.0 IGF1 -0.067 0.187 -9999.0 0.0 -0.503 57.0 57.0 DIAPH1 -0.014 0.09 -9999.0 0.0 -0.58 9.0 9.0 Wnt receptor signaling pathway -0.02 0.042 0.265 8.0 -9999.0 0.0 8.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.015 0.056 -9999.0 0.0 -0.435 2.0 2.0 CTNNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.027 0.057 -9999.0 0.0 -0.5 2.0 2.0 EFNA1 -0.001 0.082 -9999.0 0.0 -0.519 9.0 9.0 LPP 0.028 0.043 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.017 0.066 -9999.0 0.0 -0.497 2.0 2.0 SEC6/SEC8 -0.006 0.034 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.001 0.091 -9999.0 0.0 -0.271 27.0 27.0 HGF/MET -0.049 0.111 -9999.0 0.0 -0.514 9.0 9.0 HGF -0.043 0.16 -9999.0 0.0 -0.501 40.0 40.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.021 0.041 -9999.0 0.0 -0.239 9.0 9.0 actin cable formation 0.05 0.054 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.026 0.064 -9999.0 0.0 -0.617 2.0 2.0 KIFC3 0.022 0.05 -9999.0 0.0 -0.25 12.0 12.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.025 0.041 -9999.0 0.0 -0.248 8.0 8.0 NCK1/GIT1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.02 0.042 -9999.0 0.0 -0.265 8.0 8.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.025 0.042 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.041 -9999.0 0.0 -0.248 8.0 8.0 LIMA1 0.011 0.029 -9999.0 0.0 -0.538 1.0 1.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.034 0.061 -9999.0 0.0 -0.377 2.0 2.0 adherens junction assembly 0.034 0.076 -9999.0 0.0 -0.488 4.0 4.0 IGF-1R heterotetramer/IGF1 -0.057 0.121 -9999.0 0.0 -0.549 10.0 10.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.016 0.03 -9999.0 0.0 -0.385 2.0 2.0 MET -0.035 0.153 -9999.0 0.0 -0.522 33.0 33.0 PLEKHA7 0.024 0.05 -9999.0 0.0 -0.385 2.0 2.0 mol:GTP 0.015 0.067 -9999.0 0.0 -0.283 14.0 14.0 establishment of epithelial cell apical/basal polarity 0.043 0.042 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.021 0.041 -9999.0 0.0 -0.238 9.0 9.0 regulation of cell-cell adhesion 0.026 0.055 -9999.0 0.0 -0.486 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.021 0.041 -9999.0 0.0 -0.239 9.0 9.0