E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.012 0.1 -9999.0 0.0 -0.35 13.0 13.0 KLHL20 -0.008 0.074 0.174 1.0 -0.224 24.0 25.0 CYFIP2 0.014 0.067 -9999.0 0.0 -0.403 9.0 9.0 Rac1/GDP 0.002 0.075 -9999.0 0.0 -0.267 11.0 11.0 ENAH -0.018 0.1 -9999.0 0.0 -0.285 39.0 39.0 AP1M1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.025 0.001 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.023 0.023 -9999.0 0.0 -0.403 1.0 1.0 CDC42/GTP 0.018 0.035 -9999.0 0.0 -0.174 5.0 5.0 ABI1/Sra1/Nap1 -0.021 0.045 -9999.0 0.0 -0.152 26.0 26.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.046 0.054 -9999.0 0.0 -0.216 12.0 12.0 RAPGEF1 -0.007 0.08 -9999.0 0.0 -0.336 8.0 8.0 CTNND1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.009 0.108 -9999.0 0.0 -0.288 45.0 45.0 CRK -0.008 0.083 -9999.0 0.0 -0.337 10.0 10.0 E-cadherin/gamma catenin/alpha catenin 0.039 0.048 -9999.0 0.0 -0.325 5.0 5.0 alphaE/beta7 Integrin 0.029 0.043 -9999.0 0.0 -0.285 6.0 6.0 IQGAP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.048 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.01 0.097 -9999.0 0.0 -0.29 35.0 35.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.001 0.03 -9999.0 0.0 -0.202 3.0 3.0 MLLT4 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.039 0.041 -9999.0 0.0 -0.215 8.0 8.0 PI3K 0.002 0.039 -9999.0 0.0 -0.261 3.0 3.0 ARF6 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.027 0.051 -9999.0 0.0 -0.378 5.0 5.0 TIAM1 0.016 0.063 -9999.0 0.0 -0.403 8.0 8.0 E-cadherin(dimer)/Ca2+ 0.048 0.039 -9999.0 0.0 -0.203 6.0 6.0 AKT1 -0.009 0.025 0.099 1.0 -0.163 2.0 3.0 PIK3R1 0.003 0.091 -9999.0 0.0 -0.403 17.0 17.0 CDH1 0.017 0.05 -9999.0 0.0 -0.403 5.0 5.0 RhoA/GDP 0.004 0.073 -9999.0 0.0 -0.265 10.0 10.0 actin cytoskeleton organization -0.004 0.056 0.169 2.0 -0.166 22.0 24.0 CDC42/GDP 0.005 0.074 -9999.0 0.0 -0.266 11.0 11.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.012 0.039 -9999.0 0.0 -0.289 5.0 5.0 ITGB7 0.017 0.055 -9999.0 0.0 -0.403 6.0 6.0 RAC1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.052 0.042 -9999.0 0.0 -0.216 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.035 0.035 -9999.0 0.0 -0.2 6.0 6.0 mol:GDP -0.011 0.08 -9999.0 0.0 -0.302 12.0 12.0 CDC42/GTP/IQGAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.022 0.032 -9999.0 0.0 -0.403 2.0 2.0 p120 catenin/RhoA/GDP 0.011 0.076 -9999.0 0.0 -0.272 9.0 9.0 RAC1/GTP/IQGAP1 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.001 0.051 0.137 3.0 -0.163 19.0 22.0 NME1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.007 0.093 -9999.0 0.0 -0.287 33.0 33.0 regulation of cell-cell adhesion 0.011 0.03 -9999.0 0.0 -0.155 6.0 6.0 WASF2 -0.001 0.031 -9999.0 0.0 -0.113 3.0 3.0 Rap1/GTP 0.022 0.044 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.055 0.061 -9999.0 0.0 -0.24 11.0 11.0 CCND1 -0.002 0.062 0.157 3.0 -0.206 18.0 21.0 VAV2 -0.037 0.185 -9999.0 0.0 -0.587 29.0 29.0 RAP1/GDP 0.019 0.065 0.206 1.0 -0.294 3.0 4.0 adherens junction assembly -0.006 0.091 -9999.0 0.0 -0.28 33.0 33.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.039 0.056 -9999.0 0.0 -0.228 12.0 12.0 E-cadherin/beta catenin 0.007 0.039 -9999.0 0.0 -0.288 6.0 6.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.014 0.102 -9999.0 0.0 -0.288 39.0 39.0 PIK3CA 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.027 0.11 -9999.0 0.0 -0.355 26.0 26.0 E-cadherin/beta catenin/alpha catenin 0.04 0.04 -9999.0 0.0 -0.237 6.0 6.0 ITGAE 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.01 0.109 -9999.0 0.0 -0.293 45.0 45.0