Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.09 0.186 -9999.0 0.0 -0.579 32.0 32.0 IHH -0.132 0.202 -9999.0 0.0 -0.436 105.0 105.0 SHH Np/Cholesterol/GAS1 -0.038 0.101 -9999.0 0.0 -0.242 65.0 65.0 LRPAP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.037 0.1 0.24 65.0 -9999.0 0.0 65.0 SMO/beta Arrestin2 -0.092 0.191 -9999.0 0.0 -0.366 96.0 96.0 SMO -0.108 0.19 -9999.0 0.0 -0.379 101.0 101.0 AKT1 -0.052 0.161 -9999.0 0.0 -0.513 27.0 27.0 ARRB2 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.015 0.05 -9999.0 0.0 -0.403 4.0 4.0 ADRBK1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.106 0.187 -9999.0 0.0 -0.373 101.0 101.0 STIL -0.071 0.16 0.185 22.0 -0.365 48.0 70.0 DHH N/PTCH2 0.009 0.092 -9999.0 0.0 -0.315 25.0 25.0 DHH N/PTCH1 -0.075 0.149 -9999.0 0.0 -0.268 114.0 114.0 PIK3CA 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.001 0.094 -9999.0 0.0 -0.403 18.0 18.0 PTHLH -0.122 0.234 -9999.0 0.0 -0.68 33.0 33.0 determination of left/right symmetry -0.106 0.187 -9999.0 0.0 -0.373 101.0 101.0 PIK3R1 0.003 0.091 -9999.0 0.0 -0.403 17.0 17.0 skeletal system development -0.121 0.231 -9999.0 0.0 -0.672 33.0 33.0 IHH N/Hhip -0.098 0.182 -9999.0 0.0 -0.328 125.0 125.0 DHH N/Hhip -0.03 0.129 -9999.0 0.0 -0.301 63.0 63.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.106 0.187 -9999.0 0.0 -0.373 101.0 101.0 pancreas development -0.042 0.147 -9999.0 0.0 -0.403 50.0 50.0 HHAT 0.011 0.067 -9999.0 0.0 -0.403 9.0 9.0 PI3K 0.025 0.052 -9999.0 0.0 -0.285 9.0 9.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.024 0.121 -9999.0 0.0 -0.403 31.0 31.0 somite specification -0.106 0.187 -9999.0 0.0 -0.373 101.0 101.0 SHH Np/Cholesterol/PTCH1 -0.087 0.151 -9999.0 0.0 -0.345 64.0 64.0 SHH Np/Cholesterol/PTCH2 -0.021 0.092 -9999.0 0.0 -0.244 47.0 47.0 SHH Np/Cholesterol/Megalin -0.058 0.113 -9999.0 0.0 -0.249 83.0 83.0 SHH -0.035 0.103 -9999.0 0.0 -0.302 44.0 44.0 catabolic process -0.076 0.15 -9999.0 0.0 -0.287 110.0 110.0 SMO/Vitamin D3 -0.083 0.195 -9999.0 0.0 -0.404 63.0 63.0 SHH Np/Cholesterol/Hhip -0.048 0.115 -9999.0 0.0 -0.255 77.0 77.0 LRP2 -0.071 0.154 -9999.0 0.0 -0.403 60.0 60.0 receptor-mediated endocytosis -0.119 0.196 -9999.0 0.0 -0.449 63.0 63.0 SHH Np/Cholesterol/BOC -0.02 0.088 -9999.0 0.0 -0.236 46.0 46.0 SHH Np/Cholesterol/CDO -0.019 0.092 -9999.0 0.0 -0.248 45.0 45.0 mesenchymal cell differentiation 0.048 0.114 0.253 77.0 -9999.0 0.0 77.0 mol:Vitamin D3 -0.065 0.175 0.205 33.0 -0.346 64.0 97.0 IHH N/PTCH2 -0.059 0.142 -9999.0 0.0 -0.27 106.0 106.0 CDON 0.017 0.052 -9999.0 0.0 -0.403 5.0 5.0 IHH N/PTCH1 -0.074 0.16 -9999.0 0.0 -0.29 110.0 110.0 Megalin/LRPAP1 -0.038 0.116 -9999.0 0.0 -0.285 60.0 60.0 PTCH2 0.011 0.072 -9999.0 0.0 -0.403 10.0 10.0 SHH Np/Cholesterol -0.022 0.08 -9999.0 0.0 -0.228 44.0 44.0 PTCH1 -0.076 0.151 -9999.0 0.0 -0.288 110.0 110.0 HHIP -0.042 0.147 -9999.0 0.0 -0.403 50.0 50.0