E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.021 0.114 -9999.0 0.0 -0.441 27.0 27.0 KLHL20 0.016 0.069 0.239 9.0 -0.231 9.0 18.0 CYFIP2 0.03 0.045 0.266 22.0 -0.602 1.0 23.0 Rac1/GDP -0.001 0.087 -9999.0 0.0 -0.315 13.0 13.0 ENAH -0.018 0.106 -9999.0 0.0 -0.436 22.0 22.0 AP1M1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.008 0.049 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.013 0.033 -9999.0 0.0 -0.17 5.0 5.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.045 0.068 -9999.0 0.0 -0.358 16.0 16.0 RAPGEF1 -0.02 0.108 -9999.0 0.0 -0.411 23.0 23.0 CTNND1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.023 0.125 -9999.0 0.0 -0.438 34.0 34.0 CRK -0.017 0.104 -9999.0 0.0 -0.439 24.0 24.0 E-cadherin/gamma catenin/alpha catenin 0.032 0.063 -9999.0 0.0 -0.388 14.0 14.0 alphaE/beta7 Integrin 0.035 0.034 -9999.0 0.0 -0.449 2.0 2.0 IQGAP1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.041 0.023 -9999.0 0.0 -0.356 1.0 1.0 DLG1 -0.025 0.12 -9999.0 0.0 -0.444 29.0 29.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.017 0.028 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.022 0.023 -9999.0 0.0 -0.602 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.043 0.024 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.002 0.042 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.02 0.068 -9999.0 0.0 -0.449 14.0 14.0 TIAM1 0.025 0.017 0.267 4.0 -9999.0 0.0 4.0 E-cadherin(dimer)/Ca2+ 0.04 0.058 -9999.0 0.0 -0.337 14.0 14.0 AKT1 -0.007 0.034 0.146 1.0 -9999.0 0.0 1.0 PIK3R1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.011 0.081 -9999.0 0.0 -0.602 14.0 14.0 RhoA/GDP -0.0 0.087 -9999.0 0.0 -0.315 14.0 14.0 actin cytoskeleton organization 0.015 0.056 0.189 18.0 -0.173 6.0 24.0 CDC42/GDP 0.0 0.087 -9999.0 0.0 -0.316 13.0 13.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.007 0.045 -9999.0 0.0 -0.276 16.0 16.0 ITGB7 0.027 0.045 0.266 15.0 -0.602 2.0 17.0 RAC1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.044 0.062 -9999.0 0.0 -0.358 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.029 0.054 -9999.0 0.0 -0.335 14.0 14.0 mol:GDP -0.014 0.094 -9999.0 0.0 -0.363 14.0 14.0 CDC42/GTP/IQGAP1 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.004 0.09 -9999.0 0.0 -0.323 14.0 14.0 RAC1/GTP/IQGAP1 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.015 0.053 0.195 36.0 -0.251 3.0 39.0 NME1 0.024 0.024 0.266 7.0 -9999.0 0.0 7.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.023 0.118 -9999.0 0.0 -0.452 27.0 27.0 regulation of cell-cell adhesion 0.002 0.041 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.007 0.028 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.012 0.059 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.069 -9999.0 0.0 -0.34 16.0 16.0 CCND1 0.015 0.059 0.213 31.0 -0.317 3.0 34.0 VAV2 -0.021 0.155 -9999.0 0.0 -0.616 21.0 21.0 RAP1/GDP 0.005 0.072 -9999.0 0.0 -0.31 2.0 2.0 adherens junction assembly -0.023 0.115 -9999.0 0.0 -0.438 27.0 27.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.039 0.065 -9999.0 0.0 -0.33 16.0 16.0 E-cadherin/beta catenin -0.0 0.062 -9999.0 0.0 -0.349 24.0 24.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.025 0.12 -9999.0 0.0 -0.449 28.0 28.0 PIK3CA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.006 0.095 0.274 27.0 -0.35 20.0 47.0 E-cadherin/beta catenin/alpha catenin 0.033 0.062 -9999.0 0.0 -0.388 14.0 14.0 ITGAE 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.024 0.128 -9999.0 0.0 -0.451 33.0 33.0