Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.011 0.045 -9999.0 0.0 -0.271 16.0 16.0 epithelial cell differentiation 0.036 0.056 -9999.0 0.0 -0.334 14.0 14.0 CYFIP2 0.03 0.045 0.266 22.0 -0.602 1.0 23.0 ENAH -0.005 0.06 0.273 8.0 -9999.0 0.0 8.0 EGFR -0.189 0.296 -9999.0 0.0 -0.602 281.0 281.0 EPHA2 0.02 0.049 -9999.0 0.0 -0.602 5.0 5.0 MYO6 -0.014 0.052 -9999.0 0.0 -0.324 15.0 15.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.05 0.032 -9999.0 0.0 -0.388 1.0 1.0 AQP5 -0.202 0.271 0.335 1.0 -0.519 339.0 340.0 CTNND1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.013 0.05 -9999.0 0.0 -0.319 14.0 14.0 regulation of calcium-dependent cell-cell adhesion -0.026 0.08 -9999.0 0.0 -0.325 47.0 47.0 EGF -0.091 0.243 0.266 2.0 -0.602 153.0 155.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.019 0.122 -9999.0 0.0 -0.481 43.0 43.0 cortical microtubule organization 0.036 0.056 -9999.0 0.0 -0.334 14.0 14.0 GO:0000145 -0.013 0.047 -9999.0 0.0 -0.305 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.04 0.058 -9999.0 0.0 -0.338 14.0 14.0 MLLT4 0.022 0.023 -9999.0 0.0 -0.602 1.0 1.0 ARF6/GDP -0.022 0.042 -9999.0 0.0 -0.295 16.0 16.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.044 0.043 -9999.0 0.0 -0.354 5.0 5.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.004 0.049 -9999.0 0.0 -0.427 1.0 1.0 PVRL2 0.024 0.009 0.266 1.0 -9999.0 0.0 1.0 ZYX -0.014 0.05 -9999.0 0.0 -0.323 14.0 14.0 ARF6/GTP 0.048 0.044 -9999.0 0.0 -0.333 5.0 5.0 CDH1 0.011 0.081 -9999.0 0.0 -0.602 14.0 14.0 EGFR/EGFR/EGF/EGF -0.149 0.207 -9999.0 0.0 -0.354 390.0 390.0 RhoA/GDP 0.037 0.055 -9999.0 0.0 -0.321 14.0 14.0 actin cytoskeleton organization -0.015 0.049 -9999.0 0.0 -0.314 15.0 15.0 IGF-1R heterotetramer 0.013 0.082 0.266 2.0 -0.601 14.0 16.0 GIT1 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.013 0.082 0.266 2.0 -0.602 14.0 16.0 IGF1 -0.109 0.257 -9999.0 0.0 -0.602 177.0 177.0 DIAPH1 0.025 0.105 -9999.0 0.0 -0.669 2.0 2.0 Wnt receptor signaling pathway -0.036 0.056 0.334 14.0 -9999.0 0.0 14.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.022 0.042 -9999.0 0.0 -0.298 15.0 15.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.016 0.05 -9999.0 0.0 -0.322 15.0 15.0 EFNA1 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.015 0.05 -9999.0 0.0 -0.313 15.0 15.0 Ephrin A1/EPHA2 0.024 0.057 -9999.0 0.0 -0.315 17.0 17.0 SEC6/SEC8 -0.023 0.041 -9999.0 0.0 -0.304 15.0 15.0 MGAT3 -0.027 0.081 -9999.0 0.0 -0.33 47.0 47.0 HGF/MET -0.043 0.163 -9999.0 0.0 -0.345 174.0 174.0 HGF -0.01 0.142 -9999.0 0.0 -0.602 45.0 45.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.011 0.046 -9999.0 0.0 -0.273 16.0 16.0 actin cable formation 0.04 0.095 0.307 28.0 -0.304 1.0 29.0 KIAA1543 -0.014 0.051 -9999.0 0.0 -0.33 14.0 14.0 KIFC3 -0.014 0.048 -9999.0 0.0 -0.324 14.0 14.0 NCK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.013 0.05 -9999.0 0.0 -0.324 14.0 14.0 NCK1/GIT1 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.036 0.056 -9999.0 0.0 -0.334 14.0 14.0 EXOC4 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.013 0.05 -9999.0 0.0 -0.324 14.0 14.0 PIP5K1C -0.014 0.051 -9999.0 0.0 -0.324 14.0 14.0 LIMA1 0.024 0.022 -9999.0 0.0 -0.602 1.0 1.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.015 0.088 0.296 20.0 -9999.0 0.0 20.0 adherens junction assembly -0.026 0.107 0.283 1.0 -0.628 14.0 15.0 IGF-1R heterotetramer/IGF1 -0.047 0.156 -9999.0 0.0 -0.327 183.0 183.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.024 -9999.0 0.0 -0.282 3.0 3.0 MET -0.079 0.232 -9999.0 0.0 -0.602 136.0 136.0 PLEKHA7 -0.014 0.054 -9999.0 0.0 -0.345 14.0 14.0 mol:GTP 0.042 0.042 -9999.0 0.0 -0.352 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.009 0.066 0.349 5.0 -9999.0 0.0 5.0 cortical actin cytoskeleton stabilization 0.011 0.045 -9999.0 0.0 -0.271 16.0 16.0 regulation of cell-cell adhesion -0.015 0.049 -9999.0 0.0 -0.314 15.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.011 0.046 -9999.0 0.0 -0.273 16.0 16.0