E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.038 0.15 -9999.0 0.0 -0.432 44.0 44.0 KLHL20 0.042 0.115 0.307 41.0 -0.276 10.0 51.0 CYFIP2 0.05 0.047 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.001 0.118 0.337 4.0 -0.302 25.0 29.0 ENAH -0.033 0.143 -9999.0 0.0 -0.431 37.0 37.0 AP1M1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.052 -9999.0 0.0 -0.544 4.0 4.0 CDC42/GTP 0.009 0.076 -9999.0 0.0 -0.276 3.0 3.0 ABI1/Sra1/Nap1 -0.016 0.04 -9999.0 0.0 -0.182 11.0 11.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.049 0.095 -9999.0 0.0 -0.311 26.0 26.0 RAPGEF1 -0.031 0.143 0.335 1.0 -0.402 38.0 39.0 CTNND1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.032 0.164 -9999.0 0.0 -0.439 51.0 51.0 CRK -0.028 0.145 0.346 1.0 -0.42 43.0 44.0 E-cadherin/gamma catenin/alpha catenin 0.037 0.089 -9999.0 0.0 -0.344 21.0 21.0 alphaE/beta7 Integrin 0.046 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.055 0.042 -9999.0 0.0 -0.31 3.0 3.0 DLG1 -0.041 0.159 -9999.0 0.0 -0.431 50.0 50.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.021 0.061 -9999.0 0.0 -0.206 10.0 10.0 MLLT4 0.029 0.046 -9999.0 0.0 -0.543 3.0 3.0 ARF6/GTP/NME1/Tiam1 0.058 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.022 0.081 -9999.0 0.0 -0.279 7.0 7.0 ARF6 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.02 0.095 -9999.0 0.0 -0.4 21.0 21.0 TIAM1 0.035 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.046 0.089 -9999.0 0.0 -0.293 26.0 26.0 AKT1 -0.007 0.057 -9999.0 0.0 -0.197 1.0 1.0 PIK3R1 -0.02 0.166 -9999.0 0.0 -0.544 47.0 47.0 CDH1 0.006 0.118 -9999.0 0.0 -0.544 22.0 22.0 RhoA/GDP -0.0 0.117 0.326 4.0 -0.35 6.0 10.0 actin cytoskeleton organization 0.037 0.094 0.257 43.0 -0.197 10.0 53.0 CDC42/GDP -0.0 0.117 0.31 6.0 -0.302 25.0 31.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.004 0.067 -9999.0 0.0 -0.252 24.0 24.0 ITGB7 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.05 0.096 -9999.0 0.0 -0.312 26.0 26.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.032 0.082 -9999.0 0.0 -0.291 26.0 26.0 mol:GDP -0.019 0.124 0.331 4.0 -0.348 25.0 29.0 CDC42/GTP/IQGAP1 0.043 0.013 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.007 0.12 0.341 3.0 -0.369 5.0 8.0 RAC1/GTP/IQGAP1 0.044 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.049 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.016 0.068 0.203 26.0 -0.226 11.0 37.0 NME1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.037 0.158 -9999.0 0.0 -0.44 47.0 47.0 regulation of cell-cell adhesion -0.001 0.061 -9999.0 0.0 -0.242 3.0 3.0 WASF2 0.02 0.044 0.119 32.0 -0.133 1.0 33.0 Rap1/GTP 0.012 0.087 0.267 2.0 -0.311 3.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.059 0.092 -9999.0 0.0 -0.3 21.0 21.0 CCND1 0.017 0.08 0.248 20.0 -0.284 11.0 31.0 VAV2 -0.02 0.193 0.413 1.0 -0.666 16.0 17.0 RAP1/GDP 0.009 0.1 0.311 3.0 -0.349 4.0 7.0 adherens junction assembly -0.035 0.155 -9999.0 0.0 -0.423 48.0 48.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.034 0.009 0.179 1.0 -9999.0 0.0 1.0 regulation of heterotypic cell-cell adhesion 0.044 0.089 -9999.0 0.0 -0.289 24.0 24.0 E-cadherin/beta catenin -0.007 0.089 -9999.0 0.0 -0.336 33.0 33.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.039 0.157 -9999.0 0.0 -0.432 49.0 49.0 PIK3CA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP 0.013 0.145 0.281 59.0 -0.442 15.0 74.0 E-cadherin/beta catenin/alpha catenin 0.036 0.096 -9999.0 0.0 -0.34 26.0 26.0 ITGAE 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.033 0.168 -9999.0 0.0 -0.448 51.0 51.0