Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.071 0.243 -9999.0 0.0 -0.673 19.0 19.0 IHH -0.063 0.21 -9999.0 0.0 -0.683 19.0 19.0 SHH Np/Cholesterol/GAS1 -0.079 0.165 -9999.0 0.0 -0.38 37.0 37.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.079 0.164 0.378 37.0 -9999.0 0.0 37.0 SMO/beta Arrestin2 -0.065 0.234 -9999.0 0.0 -0.687 16.0 16.0 SMO -0.075 0.248 -9999.0 0.0 -0.733 16.0 16.0 AKT1 -0.011 0.102 -9999.0 0.0 -0.335 1.0 1.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.072 0.196 -9999.0 0.0 -0.507 31.0 31.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.073 0.242 -9999.0 0.0 -0.697 17.0 17.0 STIL -0.036 0.178 -9999.0 0.0 -0.587 12.0 12.0 DHH N/PTCH2 -0.076 0.206 -9999.0 0.0 -0.468 37.0 37.0 DHH N/PTCH1 -0.078 0.21 -9999.0 0.0 -0.649 11.0 11.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.053 0.188 -9999.0 0.0 -0.582 21.0 21.0 PTHLH -0.099 0.311 -9999.0 0.0 -0.913 19.0 19.0 determination of left/right symmetry -0.073 0.242 -9999.0 0.0 -0.697 17.0 17.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.098 0.307 -9999.0 0.0 -0.9 19.0 19.0 IHH N/Hhip -0.142 0.246 -9999.0 0.0 -0.474 62.0 62.0 DHH N/Hhip -0.135 0.23 -9999.0 0.0 -0.44 64.0 64.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.073 0.242 -9999.0 0.0 -0.697 17.0 17.0 pancreas development -0.134 0.251 -9999.0 0.0 -0.546 50.0 50.0 HHAT 0.005 0.066 -9999.0 0.0 -0.635 2.0 2.0 PI3K 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.132 0.25 -9999.0 0.0 -0.543 50.0 50.0 somite specification -0.073 0.242 -9999.0 0.0 -0.697 17.0 17.0 SHH Np/Cholesterol/PTCH1 -0.045 0.188 -9999.0 0.0 -0.624 12.0 12.0 SHH Np/Cholesterol/PTCH2 -0.035 0.131 -9999.0 0.0 -0.369 22.0 22.0 SHH Np/Cholesterol/Megalin -0.021 0.103 -9999.0 0.0 -0.408 9.0 9.0 SHH -0.004 0.105 -9999.0 0.0 -0.449 10.0 10.0 catabolic process -0.052 0.191 -9999.0 0.0 -0.459 23.0 23.0 SMO/Vitamin D3 -0.06 0.223 -9999.0 0.0 -0.669 16.0 16.0 SHH Np/Cholesterol/Hhip -0.08 0.17 -9999.0 0.0 -0.386 38.0 38.0 LRP2 -0.022 0.106 -9999.0 0.0 -0.416 13.0 13.0 receptor-mediated endocytosis -0.059 0.213 -9999.0 0.0 -0.651 15.0 15.0 SHH Np/Cholesterol/BOC -0.044 0.137 -9999.0 0.0 -0.376 21.0 21.0 SHH Np/Cholesterol/CDO -0.008 0.102 -9999.0 0.0 -0.377 12.0 12.0 mesenchymal cell differentiation 0.08 0.168 0.383 38.0 -9999.0 0.0 38.0 mol:Vitamin D3 -0.043 0.19 -9999.0 0.0 -0.628 12.0 12.0 IHH N/PTCH2 -0.079 0.205 -9999.0 0.0 -0.466 38.0 38.0 CDON -0.007 0.1 -9999.0 0.0 -0.509 7.0 7.0 IHH N/PTCH1 -0.052 0.193 -9999.0 0.0 -0.465 23.0 23.0 Megalin/LRPAP1 -0.006 0.075 -9999.0 0.0 -0.284 13.0 13.0 PTCH2 -0.054 0.183 -9999.0 0.0 -0.539 23.0 23.0 SHH Np/Cholesterol -0.018 0.079 -9999.0 0.0 -0.351 10.0 10.0 PTCH1 -0.052 0.192 -9999.0 0.0 -0.461 23.0 23.0 HHIP -0.134 0.251 -9999.0 0.0 -0.547 50.0 50.0