Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.001 0.101 -9999.0 0.0 -0.254 18.0 18.0 epithelial cell differentiation 0.06 0.06 -9999.0 0.0 -0.267 4.0 4.0 CYFIP2 0.022 0.077 -9999.0 0.0 -0.51 3.0 3.0 ENAH -0.011 0.049 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.02 0.077 -9999.0 0.0 -0.51 3.0 3.0 EPHA2 0.014 0.075 -9999.0 0.0 -0.315 7.0 7.0 MYO6 0.012 0.047 -9999.0 0.0 -0.257 4.0 4.0 CTNNB1 0.031 0.029 -9999.0 0.0 -0.315 1.0 1.0 ABI1/Sra1/Nap1 0.058 0.059 -9999.0 0.0 -0.315 3.0 3.0 AQP5 0.008 0.049 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.012 0.047 -9999.0 0.0 -0.254 4.0 4.0 regulation of calcium-dependent cell-cell adhesion 0.001 0.067 -9999.0 0.0 -0.255 9.0 9.0 EGF -0.11 0.224 -9999.0 0.0 -0.441 44.0 44.0 NCKAP1 0.032 0.029 -9999.0 0.0 -0.315 1.0 1.0 AQP3 0.01 0.051 -9999.0 0.0 -9999.0 0.0 0.0 cortical microtubule organization 0.06 0.06 -9999.0 0.0 -0.267 4.0 4.0 GO:0000145 -0.011 0.041 -9999.0 0.0 -0.242 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.066 0.062 -9999.0 0.0 -0.27 4.0 4.0 MLLT4 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.007 0.056 -9999.0 0.0 -0.348 2.0 2.0 ARF6 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.061 0.06 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.006 0.042 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.01 0.049 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.064 0.062 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.019 0.089 -9999.0 0.0 -0.51 4.0 4.0 EGFR/EGFR/EGF/EGF -0.033 0.135 -9999.0 0.0 -0.488 1.0 1.0 RhoA/GDP 0.062 0.058 -9999.0 0.0 -0.255 4.0 4.0 actin cytoskeleton organization 0.004 0.045 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.287 0.267 -9999.0 0.0 -0.51 86.0 86.0 DIAPH1 0.049 0.132 -9999.0 0.0 -0.657 3.0 3.0 Wnt receptor signaling pathway -0.06 0.06 0.267 4.0 -9999.0 0.0 4.0 RHOA 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.007 0.056 -9999.0 0.0 -0.35 2.0 2.0 CTNNA1 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.004 0.046 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.001 0.044 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 0.039 0.076 -9999.0 0.0 -0.381 2.0 2.0 SEC6/SEC8 0.01 0.044 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.001 0.068 -9999.0 0.0 -0.259 9.0 9.0 HGF/MET -0.04 0.106 -9999.0 0.0 -0.381 1.0 1.0 HGF 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.002 0.101 -9999.0 0.0 -0.256 18.0 18.0 actin cable formation 0.014 0.071 0.253 4.0 -0.306 1.0 5.0 KIAA1543 -0.012 0.041 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 0.011 0.049 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.01 0.047 -9999.0 0.0 -0.257 4.0 4.0 NCK1/GIT1 0.048 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.06 0.06 -9999.0 0.0 -0.267 4.0 4.0 EXOC4 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.012 0.047 -9999.0 0.0 -0.257 4.0 4.0 PIP5K1C 0.012 0.047 -9999.0 0.0 -0.257 4.0 4.0 LIMA1 -0.022 0.165 -9999.0 0.0 -0.51 15.0 15.0 ABI1 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.005 0.065 0.307 1.0 -0.311 2.0 3.0 adherens junction assembly 0.007 0.05 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.129 0.16 -9999.0 0.0 -0.453 3.0 3.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.049 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.125 0.173 -9999.0 0.0 -0.315 66.0 66.0 PLEKHA7 0.012 0.047 -9999.0 0.0 -0.257 4.0 4.0 mol:GTP 0.059 0.059 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.023 0.068 0.335 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization -0.001 0.101 -9999.0 0.0 -0.254 18.0 18.0 regulation of cell-cell adhesion 0.004 0.045 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.002 0.101 -9999.0 0.0 -0.256 18.0 18.0