rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(121), APC2(1), AXIN1(1), AXIN2(7), BTRC(2), CACYBP(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CCND2(1), CCND3(1), CER1(3), CHD8(4), CREBBP(21), CSNK1A1(2), CSNK1A1L(5), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTBP1(1), CTBP2(2), CTNNB1(8), CTNNBIP1(1), CUL1(7), CXXC4(1), DAAM1(1), DAAM2(5), DKK1(3), DKK2(5), DKK4(4), DVL2(8), DVL3(2), EP300(13), FBXW11(7), FZD10(4), FZD2(2), FZD3(10), FZD4(1), FZD6(3), FZD7(3), FZD8(1), GSK3B(7), LEF1(4), LRP5(5), LRP6(10), MAP3K7(2), MAPK10(4), MAPK8(2), MAPK9(3), MMP7(3), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NKD1(3), NKD2(1), NLK(1), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PORCN(2), PPARD(1), PPP2CA(1), PPP2R1A(4), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(3), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRICKLE1(8), PRICKLE2(5), PRKACB(1), PRKACG(2), PRKCA(2), PRKCG(8), PRKX(2), PSEN1(3), RHOA(4), ROCK1(8), ROCK2(2), RUVBL1(6), SENP2(2), SFRP1(2), SFRP2(1), SFRP4(3), SFRP5(1), SIAH1(1), SKP1(1), SMAD2(11), SMAD3(6), SMAD4(21), SOX17(2), TBL1X(5), TBL1XR1(6), TCF7(3), TCF7L1(3), TCF7L2(13), TP53(77), VANGL1(2), VANGL2(5), WIF1(2), WNT1(1), WNT10B(3), WNT11(3), WNT16(2), WNT2B(1), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT7A(2), WNT7B(2), WNT8A(1), WNT9A(2), WNT9B(1)	35522515	631	150	557	121	207	110	8	124	147	35	<1.00e-15	<3.24e-14
2	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(121), AXIN1(1), CCND2(1), CCND3(1), CTNNB1(8), DVL2(8), DVL3(2), FBXW2(2), FZD10(4), FZD2(2), FZD3(10), FZD6(3), FZD7(3), FZD8(1), GSK3B(7), LDLR(4), MAPK10(4), MAPK9(3), PAFAH1B1(3), PLAU(2), PPP2R5C(2), PPP2R5E(2), PRKCA(2), PRKCD(3), PRKCE(4), PRKCG(8), PRKCH(2), PRKCI(4), PRKCQ(4), PRKD1(10), RHOA(4), SFRP4(3), TCF7(3), WNT1(1), WNT10B(3), WNT11(3), WNT16(2), WNT2B(1), WNT3(4), WNT4(1), WNT5A(3), WNT7A(2), WNT7B(2)	13007053	263	129	225	48	68	34	3	45	79	34	<1.00e-15	<3.24e-14
3	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	108	ABL1(4), ANAPC1(3), ANAPC10(2), ANAPC2(1), ANAPC4(1), ANAPC5(2), ANAPC7(4), ATM(27), ATR(13), BUB1(4), BUB1B(3), BUB3(2), CCNA1(4), CCNA2(3), CCNB1(2), CCNB2(2), CCNB3(4), CCND2(1), CCND3(1), CCNE1(3), CCNE2(1), CCNH(2), CDC14A(1), CDC14B(3), CDC16(3), CDC20(3), CDC23(6), CDC25A(2), CDC25B(5), CDC25C(3), CDC27(9), CDC7(2), CDK2(2), CDK4(2), CDK6(1), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), CHEK1(1), CHEK2(1), CREBBP(21), CUL1(7), DBF4(2), E2F2(1), E2F3(1), EP300(13), ESPL1(8), GSK3B(7), HDAC1(2), HDAC2(2), MAD1L1(1), MAD2L1(1), MAD2L2(1), MCM3(1), MCM4(4), MCM5(3), MCM6(3), MCM7(2), MDM2(4), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), PKMYT1(1), PLK1(6), PRKDC(13), PTTG1(1), RB1(4), RBL1(3), RBL2(8), SKP1(1), SKP2(1), SMAD2(11), SMAD3(6), SMAD4(21), SMC1A(10), SMC1B(4), TFDP1(4), TGFB1(1), TGFB2(5), TP53(77), WEE1(3), YWHAB(2), YWHAE(3), YWHAQ(1)	30252673	414	127	377	73	128	89	8	105	81	3	<1.00e-15	<3.24e-14
4	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(1), AKT1(2), AKT2(5), APAF1(7), ATM(27), BAD(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIRC2(2), BIRC3(2), CAPN1(2), CAPN2(5), CASP10(2), CASP3(1), CASP6(1), CASP7(1), CASP8(11), CASP9(2), CFLAR(2), CHUK(4), CSF2RB(7), DFFA(2), DFFB(2), FASLG(1), IKBKB(2), IL1A(1), IL1R1(3), IL3(3), IRAK1(1), IRAK2(8), IRAK3(1), IRAK4(2), MAP3K14(2), MYD88(1), NFKB1(3), NFKB2(2), NTRK1(6), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), RELA(2), RIPK1(2), TNFRSF10A(3), TNFRSF10B(2), TNFRSF10C(6), TNFRSF1A(1), TNFSF10(1), TP53(77), TRADD(1), TRAF2(1)	18529387	298	127	250	48	91	71	6	74	55	1	<1.00e-15	<3.24e-14
5	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(3), APC(121), AXIN1(1), BMP10(2), BMP4(1), BMP5(4), BMP7(5), BMPR1A(4), BMPR2(7), CHRD(5), CTNNB1(8), GATA4(1), GSK3B(7), MAP3K7(2), MEF2C(7), MYL2(1), NKX2-5(1), NPPA(1), RFC1(10), TGFB1(1), TGFB2(5), TGFBR1(6), TGFBR2(7), TGFBR3(5), WNT1(1)	7996440	216	126	179	31	37	23	2	37	83	34	<1.00e-15	<3.24e-14
6	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), AKT2(5), ANKRD6(5), APC(121), AXIN1(1), AXIN2(7), CER1(3), CSNK1A1(2), CTNNB1(8), DACT1(5), DKK1(3), DKK2(5), DKK3(2), DKK4(4), FSTL1(5), GSK3A(2), GSK3B(7), LRP1(14), MVP(4), NKD1(3), NKD2(1), PIN1(1), PSEN1(3), PTPRA(2), SENP2(2), SFRP1(2), WIF1(2)	8848505	221	126	184	33	52	22	4	32	77	34	<1.00e-15	<3.24e-14
7	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(2), APC(121), AXIN1(1), CD14(1), CTNNB1(8), GJA1(3), GNAI1(3), GSK3B(7), IRAK1(1), LBP(1), LEF1(4), LY96(2), MYD88(1), NFKB1(3), PDPK1(1), PIK3CA(33), PIK3R1(5), PPP2CA(1), RELA(2), TIRAP(1), TLR4(7), TOLLIP(1), WNT1(1)	6608775	210	123	159	24	32	36	4	29	75	34	<1.00e-15	<3.24e-14
8	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), ADRB1(2), CSNK1D(3), DRD1(1), DRD2(3), EGF(3), EGFR(10), GJA1(3), GNA11(1), GNAI1(3), GNAQ(3), GNAS(6), GRB2(2), GRM1(9), GRM5(8), GUCY1A2(8), GUCY1A3(12), GUCY1B3(7), GUCY2C(7), GUCY2D(4), GUCY2F(7), HTR2A(2), HTR2B(1), HTR2C(6), ITPR1(11), ITPR2(12), ITPR3(11), KRAS(58), MAP2K1(3), MAP2K5(2), MAP3K2(2), MAPK1(2), MAPK3(2), MAPK7(3), NPR1(6), NPR2(9), NRAS(15), PDGFA(1), PDGFC(2), PDGFD(3), PDGFRA(13), PDGFRB(5), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PRKACB(1), PRKACG(2), PRKCA(2), PRKCG(8), PRKG1(4), PRKG2(3), PRKX(2), RAF1(4), SOS1(5), SOS2(9), SRC(3), TJP1(5), TUBA3C(9), TUBA3D(2), TUBA3E(4), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(2), TUBB2A(1), TUBB2B(3), TUBB3(1), TUBB4(2), TUBB4Q(2), TUBB6(3), TUBB8(2)	28826153	432	123	372	142	154	105	11	133	28	1	<1.00e-15	<3.24e-14
9	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(2), AKT1(2), APC(121), ASAH1(3), CAV3(2), DAG1(4), DLG4(2), EPHB2(7), GNAI1(3), GNAQ(3), ITPR1(11), ITPR2(12), ITPR3(11), KCNJ3(6), KCNJ5(3), KCNJ9(2), MAPK1(2), PITX2(2), PTX3(2), RHO(2), RYR1(19)	9853585	221	123	184	49	55	22	5	33	72	34	<1.00e-15	<3.24e-14
10	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(121), AXIN1(1), BTRC(2), CREBBP(21), CSNK1A1(2), CSNK1D(3), CSNK2A1(4), CTBP1(1), CTNNB1(8), GSK3B(7), HDAC1(2), MAP3K7(2), NLK(1), PPARD(1), PPP2CA(1), TLE1(1), WIF1(2), WNT1(1)	6371845	181	120	145	22	26	21	2	24	74	34	<1.00e-15	<3.24e-14
11	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(121), CDH1(4), CREBBP(21), EP300(13), MAP2K1(3), MAP3K7(2), MAPK3(2), TGFB1(1), TGFB2(5), TGFBR1(6), TGFBR2(7)	5849380	185	118	148	21	29	26	4	18	74	34	<1.00e-15	<3.24e-14
12	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	125	ARAF(3), BID(1), BRAF(21), CASP3(1), CD244(3), CD247(2), FASLG(1), FYN(4), GRB2(2), GZMB(1), HLA-A(1), HLA-B(3), HLA-C(2), HLA-E(1), HLA-G(1), ICAM1(2), ICAM2(1), IFNA1(1), IFNA10(1), IFNA13(2), IFNA16(4), IFNA2(3), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(2), IFNGR2(1), ITGAL(5), ITGB2(4), KIR2DL1(2), KIR2DL3(1), KIR2DL4(2), KIR3DL1(3), KIR3DL2(3), KLRC3(2), KLRD1(1), KLRK1(3), KRAS(58), LCK(2), LCP2(2), MAP2K1(3), MAPK1(2), MAPK3(2), MICB(1), NCR1(1), NCR3(1), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NRAS(15), PAK1(4), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLCG1(4), PLCG2(9), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRKCA(2), PRKCG(8), PTK2B(1), PTPN11(2), PTPN6(4), RAF1(4), SH2D1A(2), SH2D1B(1), SHC1(3), SHC3(1), SHC4(5), SOS1(5), SOS2(9), TNFRSF10A(3), TNFRSF10B(2), TNFRSF10C(6), TNFSF10(1), ULBP1(2), ULBP2(2), VAV1(11), VAV2(2), VAV3(10), ZAP70(4)	25114343	382	117	282	70	88	109	11	142	30	2	<1.00e-15	<3.24e-14
13	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(2), AKT2(5), BCL10(3), CARD11(6), CBL(2), CBLB(6), CD247(2), CD28(1), CD3D(1), CD3G(2), CD4(2), CD40LG(6), CD8B(2), CDK4(2), CHUK(4), CTLA4(1), FYN(4), GRAP2(2), GRB2(2), ICOS(1), IFNG(1), IKBKB(2), IL10(1), IL2(3), IL4(3), ITK(8), KRAS(58), LCK(2), LCP2(2), MALT1(6), MAP3K14(2), MAP3K8(2), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), NRAS(15), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRKCQ(4), PTPN6(4), PTPRC(9), RASGRP1(2), RHOA(4), SOS1(5), SOS2(9), TEC(1), VAV1(11), VAV2(2), VAV3(10), ZAP70(4)	22535762	335	115	260	86	92	100	11	106	26	0	<1.00e-15	<3.24e-14
14	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(27), CCNA1(4), CCNB1(2), CCND2(1), CCND3(1), CCNE1(3), CCNE2(1), CCNH(2), CDC25A(2), CDK2(2), CDK4(2), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), CREB3(2), CREB3L1(3), CREB3L3(1), CREB3L4(1), E2F2(1), E2F3(1), E2F4(1), E2F5(2), GBA2(5), MCM3(1), MCM4(4), MCM5(3), MCM6(3), MCM7(2), MDM2(4), MNAT1(1), MYT1(8), NACA(5), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), POLA2(2), POLE(17), RB1(4), RBL1(3), RPA1(2), RPA2(1), TFDP1(4), TFDP2(1), TNXB(14), TP53(77), WEE1(3)	16546819	234	114	206	31	71	49	1	64	47	2	<1.00e-15	<3.24e-14
15	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(2), DUSP10(4), DUSP4(1), GAB1(6), GCK(1), IL1R1(3), MAP2K4(9), MAP2K5(2), MAP3K1(6), MAP3K10(2), MAP3K11(4), MAP3K12(4), MAP3K13(8), MAP3K2(2), MAP3K3(2), MAP3K4(15), MAP3K5(5), MAP3K7(2), MAP3K9(2), MAPK10(4), MAPK7(3), MAPK8(2), MAPK9(3), MYEF2(7), NFATC3(4), NR2C2(4), PAPPA(13), SHC1(3), TP53(77), TRAF6(4), ZAK(4)	11292442	208	103	178	32	75	39	3	46	45	0	<1.00e-15	<3.24e-14
16	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(21), CPEB1(2), EGFR(10), ERBB2(6), ERBB4(16), ETS2(2), ETV6(4), FMN2(4), GRB2(2), KRAS(58), MAP2K1(3), MAPK1(2), MAPK3(2), NOTCH2(11), NOTCH3(12), NOTCH4(3), PIWIL1(5), PIWIL2(6), PIWIL3(8), PIWIL4(6), RAF1(4), SOS1(5), SOS2(9), SPIRE1(2), SPIRE2(1)	11890300	204	101	134	41	42	63	3	89	7	0	<1.00e-15	<3.24e-14
17	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(27), ATR(13), CDC25C(3), CHEK1(1), CHEK2(1), TP53(77)	3688861	122	95	95	3	39	20	2	24	36	1	<1.00e-15	<3.24e-14
18	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(21), PAX3(5), PML(3), RB1(4), SIRT1(4), SP100(4), TNFRSF1A(1), TP53(77)	4254400	119	94	91	19	42	23	3	19	31	1	<1.00e-15	<3.24e-14
19	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(3), IFNG(1), IFNGR1(2), IFNGR2(1), IKBKB(2), JAK2(6), LIN7A(2), NFKB1(3), RB1(4), RELA(2), TNFRSF1A(1), TP53(77), USH1C(5), WT1(4)	4162341	113	88	86	14	41	15	3	22	30	2	<1.00e-15	<3.24e-14
20	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(4), ABL2(5), AKT1(2), AKT2(5), ARAF(3), BAD(1), BRAF(21), BTC(2), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CBL(2), CBLB(6), CDKN1A(1), CDKN1B(1), CRKL(2), EGF(3), EGFR(10), ERBB2(6), ERBB3(11), ERBB4(16), EREG(1), GAB1(6), GRB2(2), GSK3B(7), HBEGF(1), KRAS(58), MAP2K1(3), MAP2K4(9), MAPK1(2), MAPK10(4), MAPK3(2), MAPK8(2), MAPK9(3), NRAS(15), NRG1(9), NRG2(4), NRG3(3), NRG4(1), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLCG1(4), PLCG2(9), PRKCA(2), PRKCG(8), PTK2(5), RAF1(4), RPS6KB1(3), RPS6KB2(1), SHC1(3), SHC3(1), SHC4(5), SOS1(5), SOS2(9), SRC(3), STAT5B(2)	23185071	374	121	276	78	87	114	11	130	32	0	1.33e-15	3.73e-14
21	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(7), ATM(27), ATR(13), BAI1(2), BAX(1), BID(1), CASP3(1), CASP8(11), CASP9(2), CCNB1(2), CCNB2(2), CCNB3(4), CCND2(1), CCND3(1), CCNE1(3), CCNE2(1), CCNG1(2), CDK2(2), CDK4(2), CDK6(1), CDKN1A(1), CDKN2A(1), CHEK1(1), CHEK2(1), IGF1(2), IGFBP3(2), MDM2(4), MDM4(2), PPM1D(4), PTEN(6), RCHY1(2), RFWD2(4), RPRM(1), RRM2(2), SERPINE1(1), SESN1(2), SESN2(3), SESN3(5), SIAH1(1), STEAP3(1), THBS1(8), TNFRSF10B(2), TP53(77), TSC2(1), ZMAT3(3)	14546474	223	114	194	31	64	47	5	56	49	2	1.33e-15	3.73e-14
22	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(2), BCL2(1), EGFR(10), IGF1R(7), POLR2A(6), PPP2CA(1), PRKCA(2), RB1(4), TEP1(7), TERT(2), TNKS(4), TP53(77), XRCC5(4)	6386120	127	96	100	16	53	18	1	25	29	1	1.33e-15	3.73e-14
23	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(2), MAX(1), SP1(2), SP3(2), TP53(77), WT1(4)	1582823	88	82	61	4	35	14	1	12	26	0	1.55e-15	4.16e-14
24	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ACTN1(3), ACTN2(7), ACTN3(2), ACTN4(2), APC(121), APC2(1), ARAF(3), ARHGEF1(4), ARHGEF12(7), ARHGEF4(3), ARHGEF6(7), ARHGEF7(8), ARPC1A(5), ARPC1B(2), ARPC2(1), ARPC5(1), ARPC5L(1), BDKRB2(2), BRAF(21), CD14(1), CFL1(1), CHRM1(3), CHRM2(8), CHRM3(4), CHRM5(1), CRKL(2), CSK(1), CYFIP1(5), CYFIP2(4), DIAPH1(1), DIAPH2(9), DIAPH3(3), DOCK1(5), EGF(3), EGFR(10), EZR(2), F2(2), FGD1(6), FGD3(1), FGF1(2), FGF11(2), FGF12(2), FGF13(2), FGF14(5), FGF17(1), FGF20(1), FGF21(1), FGF23(1), FGF3(1), FGF5(2), FGF6(3), FGF7(1), FGF8(1), FGF9(1), FGFR1(3), FGFR2(1), FGFR3(2), FGFR4(2), FN1(17), GIT1(2), GNA12(2), GNA13(2), GRLF1(7), IQGAP1(10), IQGAP2(9), IQGAP3(11), ITGA1(3), ITGA10(3), ITGA11(2), ITGA2(5), ITGA2B(2), ITGA3(4), ITGA4(3), ITGA5(7), ITGA6(3), ITGA7(6), ITGA8(5), ITGA9(4), ITGAD(7), ITGAE(5), ITGAL(5), ITGAM(5), ITGAV(1), ITGAX(4), ITGB1(6), ITGB2(4), ITGB3(7), ITGB4(2), ITGB5(5), ITGB6(6), ITGB7(4), ITGB8(4), KRAS(58), LIMK1(4), LIMK2(4), MAP2K1(3), MAPK1(2), MAPK3(2), MOS(2), MRAS(1), MSN(3), MYH10(8), MYH14(9), MYH9(9), MYL2(1), MYL7(1), MYLK(11), MYLK2(2), NCKAP1(8), NCKAP1L(7), NRAS(15), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PDGFA(1), PDGFRA(13), PDGFRB(5), PFN2(1), PFN4(1), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(1), PIP5K1C(3), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP1R12B(5), PTK2(5), RAF1(4), RDX(2), RHOA(4), ROCK1(8), ROCK2(2), RRAS2(1), SCIN(2), SLC9A1(2), SOS1(5), SOS2(9), SSH1(4), SSH2(4), TIAM1(12), TIAM2(14), TMSL3(1), VAV1(11), VAV2(2), VAV3(10), VCL(1), WAS(1), WASF1(1), WASF2(2), WASL(5)	61040813	855	150	721	208	260	177	23	237	122	36	1.78e-15	4.38e-14
25	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(7), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIRC2(2), BIRC3(2), CASP2(4), CASP3(1), CASP6(1), CASP7(1), CASP8(11), CASP9(2), FASLG(1), GZMB(1), MAP2K4(9), MAP3K1(6), MAP3K14(2), MAPK10(4), MDM2(4), NFKB1(3), PARP1(4), RELA(2), RIPK1(2), TNFRSF1A(1), TNFSF10(1), TP53(77), TRADD(1), TRAF1(1), TRAF2(1)	8278199	156	100	127	26	55	33	4	30	34	0	1.78e-15	4.38e-14
26	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(121), AXIN1(1), CREBBP(21), CTNNB1(8), EP300(13), GSK3B(7), HDAC1(2), LDB1(3), LEF1(4), PITX2(2), TRRAP(17), WNT1(1)	7324199	200	122	163	25	38	31	2	19	76	34	1.89e-15	4.47e-14
27	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(2), AKT2(5), BTK(6), FCER1A(2), FYN(4), GAB2(1), GRB2(2), IL13(1), IL3(3), IL4(3), INPP5D(2), KRAS(58), LCP2(2), LYN(4), MAP2K1(3), MAP2K3(2), MAP2K4(9), MAP2K6(2), MAPK1(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK3(2), MAPK8(2), MAPK9(3), MS4A2(1), NRAS(15), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PLCG1(4), PLCG2(9), PRKCA(2), PRKCD(3), PRKCE(4), RAF1(4), SOS1(5), SOS2(9), VAV1(11), VAV2(2), VAV3(10)	16017853	273	107	195	44	69	91	9	89	15	0	2.22e-15	5.07e-14
28	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(27), ATR(13), BRCA1(5), BRCA2(11), CHEK1(1), CHEK2(1), FANCA(5), FANCC(3), FANCD2(7), FANCF(1), FANCG(2), HUS1(1), MRE11A(3), RAD1(1), RAD17(2), RAD50(5), TP53(77), TREX1(2)	10008101	167	100	140	14	54	27	5	36	44	1	2.44e-15	5.34e-14
29	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(7), BAD(1), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BCL2L11(2), BID(1), BIRC2(2), BIRC3(2), BNIP3L(3), CASP1(2), CASP10(2), CASP2(4), CASP3(1), CASP4(1), CASP6(1), CASP7(1), CASP8(11), CASP9(2), CHUK(4), DFFA(2), DFFB(2), FASLG(1), GZMB(1), HELLS(4), IKBKB(2), IRF1(1), IRF2(3), IRF4(1), IRF5(3), IRF6(2), MAP2K4(9), MAP3K1(6), MAPK10(4), MDM2(4), NFKB1(3), NFKBIB(1), NFKBIE(2), RELA(2), RIPK1(2), TNFRSF10B(2), TNFRSF1A(1), TNFRSF21(4), TNFSF10(1), TP53(77), TRADD(1), TRAF1(1), TRAF2(1), TRAF3(4)	12839625	198	104	169	37	64	42	4	46	42	0	2.66e-15	5.34e-14
30	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(4), ATM(27), BUB1(4), BUB1B(3), BUB3(2), CCNA1(4), CCNA2(3), CCNB1(2), CCNB2(2), CCNB3(4), CCND2(1), CCND3(1), CCNE1(3), CCNE2(1), CCNH(2), CDAN1(1), CDC14A(1), CDC14B(3), CDC20(3), CDC25A(2), CDC25B(5), CDC25C(3), CDC7(2), CDH1(4), CDK2(2), CDK4(2), CDKN1A(1), CDKN2A(1), CHEK1(1), CHEK2(1), DTX4(3), E2F2(1), E2F3(1), E2F4(1), E2F5(2), EP300(13), ESPL1(8), GSK3B(7), HDAC1(2), HDAC2(2), HDAC3(2), HDAC4(5), HDAC5(1), HDAC6(4), MAD1L1(1), MAD2L1(1), MAD2L2(1), MCM3(1), MCM4(4), MCM5(3), MCM6(3), MCM7(2), MDM2(4), MPEG1(2), MPL(1), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), PLK1(6), PRKDC(13), PTPRA(2), PTTG1(1), RB1(4), RBL1(3), SKP2(1), SMAD4(21), TBC1D8(5), TFDP1(4), TGFB1(1), TP53(77), WEE1(3)	24336771	317	123	286	54	92	80	4	77	61	3	2.78e-15	5.34e-14
31	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(4), ATM(27), BRCA1(5), CDKN1A(1), CHEK1(1), CHEK2(1), MAPK8(2), MDM2(4), MRE11A(3), NFKB1(3), RAD50(5), RBBP8(2), RELA(2), TP53(77)	6764815	137	97	110	9	42	29	2	26	37	1	2.78e-15	5.34e-14
32	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(2), APC(121), AR(4), ASAH1(3), BRAF(21), CCL13(1), CCL15(1), DAG1(4), EGFR(10), GNA11(1), GNA15(3), GNAI1(3), GNAQ(3), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), KCNJ3(6), KCNJ5(3), KCNJ9(2), MAPK1(2), MAPK10(4), MAPK14(3), PHKA2(5), PIK3CA(33), PIK3CD(2), PIK3R1(5), PITX2(2), PTX3(2), RAF1(4), SRC(3)	11572296	291	131	221	54	59	42	8	74	74	34	3.00e-15	5.34e-14
33	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(2), APAF1(7), ATM(27), BAD(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), CASP3(1), CASP6(1), CASP7(1), CASP9(2), PRKCA(2), PTK2(5), STAT1(6), TLN1(5), TP53(77)	6214350	141	103	114	16	47	24	2	31	36	1	3.00e-15	5.34e-14
34	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CDK2(2), CDK4(2), CDKN1A(1), CDKN1B(1), CDKN2A(1), CFL1(1), E2F2(1), MDM2(4), NXT1(1), TP53(77)	1738631	91	80	64	5	31	15	0	18	27	0	3.00e-15	5.34e-14
35	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(121), ASAH1(3), CASP3(1), CERK(1), CREB1(1), CREB3(2), CREB5(2), DAG1(4), EPHB2(7), GNAQ(3), ITPKB(4), MAP2K4(9), MAPK1(2), MAPK10(4), MAPK8(2), MAPK8IP1(2), MAPK8IP3(1), MAPK9(3)	6368020	172	112	134	22	19	19	4	25	71	34	3.11e-15	5.34e-14
36	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(4), DNAJC3(1), EIF2S2(1), MAP3K14(2), NFKB1(3), RELA(2), TP53(77)	2168016	90	79	63	6	37	13	0	12	28	0	3.22e-15	5.34e-14
37	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(2), AKT2(5), BCL10(3), BTK(6), CARD11(6), CD19(3), CD22(8), CD72(3), CD79A(3), CHUK(4), CR2(9), GSK3B(7), IFITM1(1), IKBKB(2), INPP5D(2), KRAS(58), LILRB3(1), LYN(4), MALT1(6), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), NRAS(15), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLCG2(9), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PTPN6(4), RASGRP3(4), VAV1(11), VAV2(2), VAV3(10)	16345709	279	108	204	47	81	83	5	90	20	0	3.44e-15	5.34e-14
38	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(4), ATM(27), ATR(13), CCNA1(4), CCNE1(3), CDC25A(2), CDK2(2), CDK4(2), CDK6(1), CDKN1A(1), CDKN1B(1), CDKN2A(1), GSK3B(7), HDAC1(2), RB1(4), SKP2(1), TFDP1(4), TGFB1(1), TGFB2(5), TP53(77)	6785682	162	105	135	13	53	28	2	36	41	2	3.44e-15	5.34e-14
39	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(27), ATR(13), BRCA1(5), CCNB1(2), CDC25A(2), CDC25B(5), CDC25C(3), CDKN1A(1), CHEK1(1), CHEK2(1), EP300(13), MDM2(4), MYT1(8), PRKDC(13), RPS6KA1(1), TP53(77), WEE1(3), YWHAQ(1)	9213078	180	105	153	21	55	41	3	39	41	1	3.44e-15	5.34e-14
40	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CREB1(1), CREB3(2), CREB3L1(3), CREB3L2(3), CREB3L3(1), CREB3L4(1), CREBBP(21), CTNNB1(8), DCT(9), DVL2(8), DVL3(2), EDN1(1), EDNRB(7), EP300(13), FZD10(4), FZD2(2), FZD3(10), FZD4(1), FZD6(3), FZD7(3), FZD8(1), GNAI1(3), GNAO1(5), GNAQ(3), GNAS(6), GSK3B(7), KIT(6), KITLG(2), KRAS(58), LEF1(4), MAP2K1(3), MAPK1(2), MAPK3(2), MITF(2), NRAS(15), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), POMC(2), PRKACB(1), PRKACG(2), PRKCA(2), PRKCG(8), PRKX(2), RAF1(4), TCF7(3), TCF7L1(3), TCF7L2(13), TYR(2), TYRP1(2), WNT1(1), WNT10B(3), WNT11(3), WNT16(2), WNT2B(1), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT7A(2), WNT7B(2), WNT8A(1), WNT9A(2), WNT9B(1)	24126512	376	120	315	109	128	102	6	106	34	0	3.55e-15	5.34e-14
41	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(4), ADCY8(11), ARAF(3), BRAF(21), CACNA1C(10), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), CREBBP(21), EP300(13), GNAQ(3), GRIA1(18), GRIA2(10), GRIN1(1), GRIN2A(15), GRIN2B(8), GRIN2C(2), GRIN2D(3), GRM1(9), GRM5(8), ITPR1(11), ITPR2(12), ITPR3(11), KRAS(58), MAP2K1(3), MAPK1(2), MAPK3(2), NRAS(15), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRKACB(1), PRKACG(2), PRKCA(2), PRKCG(8), PRKX(2), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF3(3), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KA6(5)	21909745	362	111	284	102	116	100	11	110	25	0	3.55e-15	5.34e-14
42	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(6), APC(121), AXIN1(1), BTRC(2), CTNNB1(8), DLL1(1), GSK3B(7), PSEN1(3), WNT1(1)	4617316	150	112	114	13	16	13	1	16	70	34	4.22e-15	6.19e-14
43	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(3), BAK1(1), BAX(1), BFAR(1), BTK(6), CAD(10), CASP10(2), CASP3(1), CASP8(11), CASP8AP2(12), CD7(1), CSNK1A1(2), DFFA(2), DIABLO(1), EGFR(10), EPHB2(7), FAF1(4), FAIM2(3), IL1A(1), MAP2K4(9), MAP3K1(6), MAP3K5(5), MAPK1(2), MAPK10(4), MAPK8(2), MAPK8IP1(2), MAPK8IP3(1), MAPK9(3), MET(4), NFAT5(5), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PFN2(1), PTPN13(8), RALBP1(4), RIPK1(2), ROCK1(8), SMPD1(6), TP53(77), TPX2(7), TRAF2(1), TUFM(1)	15855219	245	103	214	43	83	46	2	68	45	1	4.44e-15	6.36e-14
44	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(7), ATM(27), BAX(1), BCL2(1), CCNE1(3), CDK2(2), CDK4(2), CDKN1A(1), MDM2(4), PCNA(2), RB1(4), TIMP3(2), TP53(77)	4165855	133	100	106	8	40	23	0	34	34	2	4.55e-15	6.37e-14
45	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(27), CDC25A(2), CDC25B(5), CDC25C(3), CDK2(2), CDK4(2), CHEK1(1), MYT1(8), RB1(4), TP53(77), WEE1(3)	4041949	134	102	107	7	40	25	0	32	35	2	5.44e-15	7.45e-14
46	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(4), CDKN2A(1), MDM2(4), PIK3CA(33), PIK3R1(5), POLR1A(7), POLR1B(6), POLR1C(2), POLR1D(2), RB1(4), TP53(77)	4363248	145	103	103	8	41	45	1	27	30	1	5.66e-15	7.57e-14
47	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(3), BRAF(21), C7orf16(4), CACNA1A(8), CRHR1(1), GNA11(1), GNA12(2), GNA13(2), GNAI1(3), GNAO1(5), GNAQ(3), GNAS(6), GNAZ(1), GRIA1(18), GRIA2(10), GRIA3(5), GRID2(10), GRM1(9), GRM5(8), GUCY1A2(8), GUCY1A3(12), GUCY1B3(7), GUCY2C(7), GUCY2D(4), GUCY2F(7), IGF1(2), IGF1R(7), ITPR1(11), ITPR2(12), ITPR3(11), KRAS(58), LYN(4), MAP2K1(3), MAPK1(2), MAPK3(2), NOS1(5), NOS3(2), NPR1(6), NPR2(9), NRAS(15), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PPP2CA(1), PPP2R1A(4), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(3), PRKCA(2), PRKCG(8), PRKG1(4), PRKG2(3), RAF1(4), RYR1(19)	24206185	397	118	317	118	129	105	8	132	23	0	5.77e-15	7.57e-14
48	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(2), AKT2(5), BAD(1), CASP9(2), KDR(8), KRAS(58), MAP2K1(3), MAPK1(2), MAPK12(2), MAPK14(3), MAPK3(2), MAPKAPK2(3), MAPKAPK3(1), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NOS3(2), NRAS(15), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PLCG1(4), PLCG2(9), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRKCA(2), PRKCG(8), PTGS2(2), PTK2(5), RAF1(4), SH2D2A(1), SPHK2(1), SRC(3), VEGFA(2)	16089081	242	105	167	48	67	76	4	76	19	0	6.33e-15	8.12e-14
49	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(6), AKT1(2), ATM(27), BAX(1), CDKN1A(1), CPB2(1), CSNK1A1(2), CSNK1D(3), FHL2(1), HIF1A(1), IGFBP3(2), MAPK8(2), MDM2(4), NFKBIB(1), NQO1(1), TP53(77)	4599295	132	99	105	6	37	28	1	31	34	1	6.55e-15	8.23e-14
50	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(13), ACVR1C(2), AKT1(2), AKT2(5), ARRB1(1), BDNF(1), BRAF(21), CACNA1A(8), CACNA1B(7), CACNA1C(10), CACNA1D(7), CACNA1E(15), CACNA1F(12), CACNA1G(10), CACNA1H(2), CACNA1I(3), CACNA1S(10), CACNA2D1(8), CACNA2D2(1), CACNA2D3(3), CACNA2D4(3), CACNB1(1), CACNB2(5), CACNB3(1), CACNG1(2), CACNG2(2), CACNG3(5), CACNG4(2), CACNG5(5), CACNG7(3), CACNG8(1), CASP3(1), CD14(1), CDC25B(5), CHUK(4), CRKL(2), DUSP1(2), DUSP10(4), DUSP16(3), DUSP3(1), DUSP4(1), DUSP5(1), DUSP6(4), DUSP7(1), DUSP9(1), ECSIT(2), EGF(3), EGFR(10), ELK4(1), FASLG(1), FGF1(2), FGF11(2), FGF12(2), FGF13(2), FGF14(5), FGF17(1), FGF20(1), FGF21(1), FGF23(1), FGF3(1), FGF5(2), FGF6(3), FGF7(1), FGF8(1), FGF9(1), FGFR1(3), FGFR2(1), FGFR3(2), FGFR4(2), FLNA(2), FLNB(14), FLNC(11), GNA12(2), GRB2(2), IKBKB(2), IL1A(1), IL1R1(3), IL1R2(3), KRAS(58), MAP2K1(3), MAP2K3(2), MAP2K4(9), MAP2K5(2), MAP2K6(2), MAP3K1(6), MAP3K10(2), MAP3K12(4), MAP3K13(8), MAP3K14(2), MAP3K2(2), MAP3K3(2), MAP3K4(15), MAP3K5(5), MAP3K6(6), MAP3K7(2), MAP3K8(2), MAP4K1(2), MAP4K3(3), MAP4K4(5), MAPK1(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK3(2), MAPK7(3), MAPK8(2), MAPK8IP1(2), MAPK8IP3(1), MAPK9(3), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(1), MAPT(4), MAX(1), MEF2C(7), MKNK1(1), MKNK2(2), MOS(2), MRAS(1), NF1(5), NFATC2(3), NFATC4(4), NFKB1(3), NFKB2(2), NLK(1), NR4A1(2), NRAS(15), NTF3(1), NTRK1(6), NTRK2(3), PAK1(4), PAK2(2), PDGFA(1), PDGFRA(13), PDGFRB(5), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PPM1A(7), PPM1B(1), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PPP5C(2), PRKACB(1), PRKACG(2), PRKCA(2), PRKCG(8), PRKX(2), PTPN5(1), PTPN7(1), PTPRR(1), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF2(8), RASA1(5), RASA2(1), RASGRF1(9), RASGRF2(5), RASGRP1(2), RASGRP2(5), RASGRP3(4), RASGRP4(1), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KA5(3), RPS6KA6(5), RRAS2(1), SOS1(5), SOS2(9), SRF(3), STK3(3), STK4(3), STMN1(1), TAOK1(5), TAOK2(2), TAOK3(4), TGFB1(1), TGFB2(5), TGFBR1(6), TGFBR2(7), TNFRSF1A(1), TP53(77), TRAF2(1), TRAF6(4), ZAK(4)	62215687	808	146	695	232	292	182	14	225	93	2	1.22e-14	1.50e-13
51	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3D(1), CD3G(2), CTLA4(1), GRB2(2), HLA-DRA(4), HLA-DRB1(1), ICOS(1), IL2(3), ITK(8), LCK(2), PIK3CA(33), PIK3R1(5), PTPN11(2)	2809264	66	43	50	8	12	28	3	16	5	2	8.44e-14	1.02e-12
52	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), AKAP10(2), AKAP11(4), AKAP12(11), AKAP3(6), AKAP4(2), AKAP5(3), AKAP6(10), AKAP7(2), AKAP8(3), AKAP9(20), ARHGEF1(4), GNA11(1), GNA12(2), GNA13(2), GNA14(5), GNA15(3), GNAL(3), GNAO1(5), GNAQ(3), GNAZ(1), GNB1(1), GNB3(3), GNB5(1), GNG3(2), GNG7(1), ITPR1(11), KCNJ3(6), KRAS(58), NRAS(15), PDE1A(3), PDE1B(2), PDE1C(7), PDE4A(4), PDE4B(2), PDE4C(2), PDE4D(3), PDE7A(3), PDE7B(3), PDE8A(1), PDE8B(6), PLCB3(3), PPP3CA(1), PPP3CC(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(4), PRKCG(8), PRKCH(2), PRKCI(4), PRKCQ(4), PRKD1(10), PRKD3(6), RHOA(4), SLC9A1(2), USP5(3)	25896794	345	110	283	108	109	91	10	103	31	1	2.72e-13	3.22e-12
53	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), CACNA1C(10), CACNA1D(7), CACNA1F(12), CACNA1S(10), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CGA(1), EGFR(10), FSHB(1), GNA11(1), GNAQ(3), GNAS(6), GNRHR(4), GRB2(2), HBEGF(1), ITPR1(11), ITPR2(12), ITPR3(11), KRAS(58), LHB(1), MAP2K1(3), MAP2K3(2), MAP2K4(9), MAP2K6(2), MAP3K1(6), MAP3K2(2), MAP3K3(2), MAP3K4(15), MAPK1(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK3(2), MAPK7(3), MAPK8(2), MAPK9(3), MMP14(4), MMP2(2), NRAS(15), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PLD1(8), PLD2(1), PRKACB(1), PRKACG(2), PRKCA(2), PRKCD(3), PRKX(2), PTK2B(1), RAF1(4), SOS1(5), SOS2(9), SRC(3)	28207791	377	113	315	115	120	99	11	122	25	0	5.14e-13	5.98e-12
54	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(2), PIK3CA(33), PIK3R1(5), PLCB1(8), PLCG1(4), PRKCA(2), VAV1(11)	2868653	65	44	50	10	18	23	3	16	5	0	9.40e-12	1.07e-10
55	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(2), GRB2(2), KLK2(3), NTRK1(6), PIK3CA(33), PIK3R1(5), PLCG1(4), PRKCA(2), SHC1(3), SOS1(5)	3455502	65	47	47	9	10	25	4	20	6	0	1.65e-11	1.85e-10
56	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(2), CAT(2), GH1(1), GHR(6), IGF1(2), IGF1R(7), PIK3CA(33), PIK3R1(5), SHC1(3), SOD2(4)	2910542	65	43	49	8	18	23	2	17	5	0	2.16e-10	2.38e-09
57	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(2), BAD(1), GRB2(2), IGF1R(7), IRS1(5), MAP2K1(3), MAPK1(2), MAPK3(2), PIK3CA(33), PIK3R1(5), RAF1(4), SHC1(3), SOS1(5)	4163019	74	49	57	9	18	27	5	18	6	0	2.49e-10	2.69e-09
58	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(14), ACACB(14), AKT1(2), AKT2(5), ARAF(3), BAD(1), BRAF(21), CBL(2), CBLB(6), CRKL(2), EXOC7(1), FASN(1), FBP2(2), FLOT1(3), FOXO1(1), G6PC(3), GCK(1), GRB2(2), GSK3B(7), GYS1(1), GYS2(8), IKBKB(2), INPP5D(2), INSR(5), IRS1(5), IRS4(11), KRAS(58), LIPE(3), MAP2K1(3), MAPK1(2), MAPK10(4), MAPK3(2), MAPK8(2), MAPK9(3), MKNK1(1), MKNK2(2), NRAS(15), PCK2(3), PDE3A(5), PDE3B(2), PDPK1(1), PFKL(1), PFKM(1), PFKP(2), PHKA1(4), PHKA2(5), PHKB(4), PHKG2(2), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PKM2(2), PPARGC1A(5), PPP1CB(1), PPP1CC(1), PPP1R3A(8), PPP1R3B(1), PPP1R3C(2), PPP1R3D(1), PRKAA1(2), PRKAA2(6), PRKAB1(1), PRKAB2(1), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAG2(2), PRKAG3(4), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCI(4), PRKX(2), PTPN1(4), PTPRF(8), PYGB(4), PYGL(2), PYGM(2), RAF1(4), RAPGEF1(4), RPS6KB1(3), RPS6KB2(1), SHC1(3), SHC3(1), SHC4(5), SLC2A4(3), SOCS2(2), SORBS1(7), SOS1(5), SOS2(9), SREBF1(1), TSC1(3), TSC2(1)	35828615	429	119	334	120	112	123	9	154	31	0	2.63e-10	2.79e-09
59	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(3), CDK2(2), CUL1(7), FBXW7(33), RB1(4), TFDP1(4)	1965496	53	36	41	5	21	3	1	17	10	1	6.28e-10	6.56e-09
60	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(3), HLA-A(1), ITGB1(6), KLRC3(2), KLRC4(1), KLRD1(1), MAP2K1(3), MAPK3(2), PAK1(4), PIK3CA(33), PIK3R1(5), PTK2B(1), PTPN6(4), VAV1(11)	4085692	77	47	62	12	20	26	4	18	9	0	6.44e-10	6.61e-09
61	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(1), ACTR3(2), ARPC1A(5), ARPC1B(2), ARPC2(1), PAK1(4), PDGFRA(13), PIK3CA(33), PIK3R1(5), WASL(5)	2951856	71	38	56	12	14	27	3	18	8	1	8.45e-10	8.53e-09
62	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(2), CDKN1B(1), GRB2(2), ITGB1(6), MAPK1(2), MAPK3(2), PDK2(1), PDPK1(1), PIK3CA(33), PIK3R1(5), PTEN(6), PTK2(5), SHC1(3), SOS1(5)	4268964	74	45	57	12	13	28	4	19	9	1	1.38e-09	1.38e-08
63	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(2), ASAH1(3), ATF1(1), BRAF(21), CREB1(1), CREB3(2), CREB5(2), CREBBP(21), CRKL(2), DAG1(4), EGR1(2), EGR2(6), EGR3(2), FRS2(2), GNAQ(3), MAP1B(18), MAP2K4(9), MAPK1(2), MAPK10(4), MAPK3(2), MAPK8(2), MAPK8IP1(2), MAPK8IP3(1), MAPK9(3), NTRK1(6), PIK3C2G(7), PIK3CA(33), PIK3CD(2), PIK3R1(5), PTPN11(2), RPS6KA3(3), SHC1(3), SRC(3), TERF2IP(1)	11312070	182	78	146	42	38	57	5	58	23	1	1.52e-09	1.48e-08
64	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(2), BAD(1), CHRNB1(3), CHRNG(2), MUSK(2), PIK3CA(33), PIK3R1(5), PTK2(5), PTK2B(1), RAPSN(2), SRC(3), TERT(2)	3541849	61	44	46	15	14	25	2	11	9	0	1.85e-09	1.78e-08
65	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(2), AKT2(5), CDKN1A(1), GRB2(2), MAP2K1(3), NGFR(2), NTRK1(6), PIK3CA(33), PIK3CD(2), SHC1(3), SOS1(5)	3580194	64	44	48	11	14	24	6	16	4	0	2.64e-09	2.50e-08
66	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(4), GRB2(2), KLK2(3), MAP2K1(3), MAPK3(2), MAPK8(2), NGFR(2), PIK3CA(33), PIK3R1(5), PLCG1(4), RAF1(4), SHC1(3), SOS1(5)	4221865	72	45	53	8	15	28	5	19	5	0	5.06e-09	4.72e-08
67	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(2), BAD(1), CASP9(2), CHUK(4), GH1(1), GHR(6), NFKB1(3), PDPK1(1), PIK3CA(33), PIK3R1(5), PPP2CA(1), RELA(2)	3155461	61	41	46	9	14	24	2	16	5	0	5.84e-09	5.37e-08
68	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), GSK3B(7), IGF1(2), IGF1R(7), INPPL1(3), PDK2(1), PDPK1(1), PIK3CA(33), PIK3R1(5), PPP2CA(1), PTEN(6), RPS6KB1(3)	4345997	78	46	62	11	22	27	4	14	10	1	7.12e-09	6.45e-08
69	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	AKT1(2), GNAS(6), GNB1(1), NFKB1(3), NOS3(2), NPPA(1), NR3C1(3), PIK3CA(33), PIK3R1(5), RELA(2), SYT1(1)	3941640	59	44	44	14	14	21	3	15	6	0	9.71e-09	8.67e-08
70	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(2), CREB1(1), GRB2(2), MAPK1(2), MAPK3(2), MAPK7(3), MEF2A(3), MEF2C(7), MEF2D(1), NTRK1(6), PIK3CA(33), PIK3R1(5), PLCG1(4), RPS6KA1(1), SHC1(3)	4090860	75	45	59	14	19	30	3	17	6	0	1.12e-08	9.83e-08
71	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(2), BAD(1), BCL2L1(1), CASP9(2), CHUK(4), MAP2K1(3), MAPK3(2), NFKB1(3), PIK3CA(33), PIK3R1(5), RAF1(4), RALBP1(4), RALGDS(1), RELA(2), RHOA(4)	4268045	71	46	55	9	22	27	4	11	7	0	1.89e-08	1.64e-07
72	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(2), CREB1(1), MAP2K1(3), MAP2K3(2), MAP2K6(2), MAP3K1(6), MAPK1(2), MAPK14(3), MAPK3(2), NFKB1(3), PIK3CA(33), PIK3R1(5), RB1(4), RELA(2), SP1(2)	4322505	72	43	57	11	17	28	4	16	6	1	5.40e-08	4.62e-07
73	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(4), ABLIM1(5), ABLIM2(4), ABLIM3(5), ARHGEF12(7), CFL1(1), CXCL12(1), CXCR4(3), DCC(14), DPYSL2(3), DPYSL5(1), EFNA3(1), EFNA4(1), EFNA5(2), EFNB1(3), EFNB3(2), EPHA1(3), EPHA2(5), EPHA3(14), EPHA4(4), EPHA5(11), EPHA6(5), EPHA7(7), EPHA8(5), EPHB1(6), EPHB2(7), EPHB3(2), EPHB4(2), EPHB6(4), FYN(4), GNAI1(3), GSK3B(7), ITGB1(6), KRAS(58), L1CAM(2), LIMK1(4), LIMK2(4), LRRC4C(6), MAPK1(2), MAPK3(2), MET(4), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NGEF(1), NRAS(15), NRP1(1), NTN1(4), NTN4(4), NTNG1(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PLXNA1(2), PLXNA2(5), PLXNA3(1), PLXNB1(3), PLXNB2(2), PLXNB3(2), PLXNC1(7), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PTK2(5), RASA1(5), RGS3(8), RHOA(4), RND1(1), ROBO1(15), ROBO2(15), ROBO3(2), ROCK1(8), ROCK2(2), SEMA3A(6), SEMA3B(1), SEMA3C(2), SEMA3D(9), SEMA3E(5), SEMA3F(1), SEMA3G(3), SEMA4A(2), SEMA4B(1), SEMA4D(12), SEMA4F(5), SEMA4G(5), SEMA5A(7), SEMA5B(7), SEMA6A(2), SEMA6C(2), SEMA6D(5), SEMA7A(2), SLIT1(9), SLIT2(12), SLIT3(7), SRGAP1(7), SRGAP2(3), SRGAP3(3), UNC5A(1), UNC5B(5), UNC5C(9), UNC5D(9)	42746281	531	124	468	159	182	130	4	159	56	0	6.44e-08	5.44e-07
74	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	CXCL12(1), CXCR4(3), GNAI1(3), GNAQ(3), GNB1(1), MAP2K1(3), MAPK1(2), MAPK3(2), NFKB1(3), PIK3C2G(7), PIK3CA(33), PIK3R1(5), PLCG1(4), PRKCA(2), PTK2(5), PTK2B(1), RAF1(4), RELA(2)	6054634	84	51	68	15	25	29	3	16	11	0	7.09e-08	5.91e-07
75	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(6), FCER1A(2), GRB2(2), LYN(4), MAP2K1(3), MAP2K4(9), MAP3K1(6), MAPK1(2), MAPK3(2), MAPK8(2), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), PAK2(2), PIK3CA(33), PIK3R1(5), PLA2G4A(5), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), RAF1(4), SHC1(3), SOS1(5), SYT1(1), VAV1(11)	9532590	131	64	113	23	40	41	7	28	15	0	8.07e-08	6.63e-07
76	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(4), AKT1(2), BAD(1), BAX(1), BCL2(1), BCL2L1(1), CSF2RB(7), IGF1(2), IGF1R(7), IL3(3), KIT(6), KITLG(2), PIK3CA(33), PIK3R1(5), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2)	4624019	82	49	66	15	26	29	3	17	7	0	1.37e-07	1.11e-06
77	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(4), GRB2(2), JAK1(3), MAP2K1(3), MAP2K4(9), MAP3K1(6), MAPK3(2), MAPK8(2), PDGFA(1), PDGFRA(13), PIK3CA(33), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(5), SHC1(3), SOS1(5), SRF(3), STAT1(6), STAT3(2)	7682854	117	56	98	23	29	41	7	27	12	1	1.69e-07	1.35e-06
78	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(2), AKT2(5), BPNT1(1), GRB2(2), MAPK1(2), MAPK3(2), PIK3CA(33), PIK3CD(2), PTEN(6), PTK2B(1), RBL2(8), SHC1(3), SOS1(5)	4509361	72	42	55	12	16	26	4	17	8	1	1.91e-07	1.50e-06
79	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(2), EIF4A2(4), EIF4G1(8), EIF4G2(7), EIF4G3(8), GHR(6), IRS1(5), MAPK1(2), MAPK14(3), MAPK3(2), MKNK1(1), PABPC1(3), PDK2(1), PDPK1(1), PIK3CA(33), PIK3R1(5), PRKCA(2), PTEN(6), RPS6KB1(3)	6214604	102	53	85	17	22	36	2	31	10	1	1.96e-07	1.53e-06
80	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(4), GRB2(2), IGF1(2), IGF1R(7), IRS1(5), MAP2K1(3), MAPK3(2), MAPK8(2), PIK3CA(33), PIK3R1(5), PTPN11(2), RAF1(4), RASA1(5), SHC1(3), SOS1(5), SRF(3)	5452214	87	50	70	11	20	32	4	24	7	0	2.08e-07	1.60e-06
81	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(1), CREBBP(21), EP300(13), FYN(4), IL7(1), IL7R(2), JAK1(3), JAK3(6), LCK(2), NMI(1), PIK3CA(33), PIK3R1(5), PTK2B(1), STAT5B(2)	6235691	95	53	79	21	25	37	3	18	12	0	2.27e-07	1.72e-06
82	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(2), BCL2(1), BCR(6), CRKL(2), GRB2(2), JAK2(6), MAP2K1(3), MAP2K4(9), MAP3K1(6), MAPK3(2), MAPK8(2), PIK3CA(33), PIK3R1(5), RAF1(4), SOS1(5), STAT1(6), STAT5B(2)	6099457	96	50	79	14	27	34	8	20	6	1	2.91e-07	2.19e-06
83	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(3), ACTA2(3), ACTN2(7), ACTN3(2), ACTN4(2), DES(1), DMD(36), FAM48A(4), MYBPC1(5), MYBPC2(4), MYBPC3(2), MYH3(9), MYH6(8), MYH7(7), MYH8(17), MYL1(1), MYL2(1), MYOM1(8), NEB(38), TMOD1(2), TNNC2(1), TNNI1(2), TNNI3(1), TNNT2(3), TPM1(2), TPM2(5), TPM3(2), TPM4(3), TTN(203), VIM(2)	25400140	384	93	373	113	129	83	6	131	29	6	3.56e-07	2.64e-06
84	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(4), AKT1(2), ASAH1(3), GNAI1(3), GNB1(1), ITGAV(1), ITGB3(7), MAPK1(2), MAPK3(2), PDGFA(1), PDGFRA(13), PIK3CA(33), PIK3R1(5), PLCB1(8), PRKCA(2), PTK2(5), SMPD1(6), SRC(3)	6116155	101	50	86	24	27	36	4	24	9	1	3.92e-07	2.87e-06
85	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(6), DIAPH1(1), FYN(4), ITGA1(3), ITGB1(6), MAP2K1(3), MAPK1(2), MAPK3(2), MYL2(1), MYLK(11), PIK3CA(33), PIK3R1(5), PTK2(5), RAF1(4), ROCK1(8), SHC1(3), SRC(3), TLN1(5)	8277589	105	60	87	20	26	37	3	25	14	0	5.07e-07	3.68e-06
86	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(4), AKT1(2), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CREB1(1), GNAS(6), GRB2(2), MAPK1(2), MAPK14(3), MAPK3(2), PIK3CA(33), PIK3R1(5), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), RPS6KA1(1), RPS6KA5(3), SOS1(5)	6423034	85	51	70	21	22	28	7	24	4	0	6.13e-07	4.39e-06
87	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	DUSP1(2), GORASP1(3), MAP2K4(9), MAPK1(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK3(2), MAPK8(2), MAPK8IP1(2), MAPK8IP3(1), MAPK9(3), MAPKAPK5(1), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PIK3CA(33), PIK3CD(2), PIK3R1(5), SYT1(1), TRAF2(1), TRAF3(4), TRAF5(4), TRAF6(4)	7395868	98	57	82	20	22	33	2	29	12	0	7.46e-07	5.28e-06
88	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(4), EGF(3), EGFR(10), GRB2(2), JAK1(3), MAP2K1(3), MAP2K4(9), MAP3K1(6), MAPK3(2), MAPK8(2), PIK3CA(33), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(5), SHC1(3), SOS1(5), SRF(3), STAT1(6), STAT3(2)	8310487	116	58	97	22	34	39	6	28	9	0	1.01e-06	7.06e-06
89	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(2), CDK5R1(1), CFL1(1), CHN1(1), LIMK1(4), MAP3K1(6), MYL2(1), MYLK(11), NCF2(1), PAK1(4), PDGFRA(13), PIK3CA(33), PIK3R1(5), PLD1(8), PPP1R12B(5), RALBP1(4), RPS6KB1(3), TRIO(12), VAV1(11), WASF1(1)	7697025	127	58	111	29	36	45	4	24	17	1	1.02e-06	7.06e-06
90	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(2), CCNE1(3), CDK2(2), CDK4(2), CDK6(1), CDKN1A(1), CDKN1B(1), MAPK1(2), MAPK3(2), NFKB1(3), PAK1(4), PIK3CA(33), PIK3R1(5), RAF1(4), RB1(4), RELA(2), TFDP1(4)	4546310	75	42	59	9	16	29	3	20	6	1	1.19e-06	8.14e-06
91	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(4), GRB2(2), INSR(5), IRS1(5), MAP2K1(3), MAPK3(2), MAPK8(2), PIK3CA(33), PIK3R1(5), PTPN11(2), RAF1(4), RASA1(5), SHC1(3), SLC2A4(3), SOS1(5), SRF(3)	5625317	86	49	69	17	17	33	4	25	7	0	1.93e-06	1.31e-05
92	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(4), ARHGEF1(4), F2(2), GNA12(2), GNA13(2), GNAI1(3), GNAQ(3), GNB1(1), MAP3K7(2), PIK3CA(33), PIK3R1(5), PLCB1(8), PPP1R12B(5), PRKCA(2), PTK2B(1), ROCK1(8)	5780954	85	47	69	18	21	26	3	25	10	0	2.13e-06	1.43e-05
93	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3D(1), CD3G(2), FYN(4), GRB2(2), LCK(2), MAP2K1(3), MAP2K4(9), MAP3K1(6), MAPK3(2), MAPK8(2), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NFKB1(3), PIK3CA(33), PIK3R1(5), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKCA(2), PTPN7(1), RAF1(4), RASA1(5), RELA(2), SHC1(3), SOS1(5), SYT1(1), VAV1(11), ZAP70(4)	10595789	136	63	118	30	43	38	8	27	20	0	3.97e-06	2.63e-05
94	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(4), GRB2(2), JAK2(6), MAP2K1(3), MAPK3(2), MPL(1), PIK3CA(33), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(5), SHC1(3), SOS1(5), STAT1(6), STAT3(2), STAT5B(2), THPO(1)	6688512	90	48	73	18	21	30	6	24	8	1	5.93e-06	3.88e-05
95	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(1), GHR(6), GRB2(2), INSR(5), IRS1(5), JAK2(6), MAP2K1(3), MAPK1(2), MAPK3(2), PIK3CA(33), PIK3R1(5), PLCG1(4), PRKCA(2), PTPN6(4), RAF1(4), RPS6KA1(1), SHC1(3), SLC2A4(3), SOS1(5), SRF(3), STAT5B(2)	7353653	101	52	84	26	29	30	5	30	6	1	1.45e-05	9.39e-05
96	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(2), EIF4A2(4), EIF4B(1), EIF4G1(8), EIF4G2(7), EIF4G3(8), MKNK1(1), PDK2(1), PDPK1(1), PIK3CA(33), PIK3R1(5), PPP2CA(1), PTEN(6), RPS6KB1(3), TSC1(3), TSC2(1)	6078580	85	46	68	18	20	33	2	19	10	1	1.52e-05	9.77e-05
97	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTB(2), ACTN1(3), ACTN2(7), ACTN3(2), ACTN4(2), AKT1(2), AKT2(5), AMOTL1(10), ASH1L(17), CASK(3), CDK4(2), CGN(6), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(4), CLDN17(5), CLDN18(2), CLDN19(1), CLDN6(2), CLDN7(2), CLDN8(3), CLDN9(1), CSDA(2), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTNNA1(10), CTNNA2(10), CTNNA3(9), CTNNB1(8), EPB41(3), EPB41L1(8), EPB41L2(6), EPB41L3(15), EXOC4(4), F11R(1), GNAI1(3), HCLS1(7), IGSF5(6), INADL(3), JAM3(3), KRAS(58), LLGL1(1), MAGI1(10), MAGI2(6), MAGI3(4), MLLT4(3), MPDZ(7), MPP5(3), MRAS(1), MYH1(8), MYH10(8), MYH11(22), MYH13(10), MYH14(9), MYH15(8), MYH2(9), MYH3(9), MYH4(11), MYH6(8), MYH7(7), MYH7B(4), MYH8(17), MYH9(9), MYL2(1), MYL7(1), NRAS(15), OCLN(1), PARD3(5), PARD6G(1), PPP2CA(1), PPP2R1A(4), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(3), PPP2R3A(3), PRKCA(2), PRKCD(3), PRKCE(4), PRKCG(8), PRKCH(2), PRKCI(4), PRKCQ(4), PTEN(6), RAB3B(1), RHOA(4), RRAS2(1), SPTAN1(9), SRC(3), SYMPK(5), TJP1(5), TJP2(5), TJP3(1), YES1(1), ZAK(4)	42352682	533	113	468	145	204	127	10	144	45	3	2.19e-05	0.000139
98	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(3), CRKL(2), DOCK1(5), GAB1(6), GRB2(2), HGF(5), ITGA1(3), ITGB1(6), MAP2K1(3), MAP4K1(2), MAPK1(2), MAPK3(2), MAPK8(2), MET(4), PAK1(4), PIK3CA(33), PIK3R1(5), PTEN(6), PTK2(5), PTK2B(1), PTPN11(2), RAF1(4), RAP1A(1), RAP1B(2), RASA1(5), SOS1(5), SRC(3), STAT3(2)	9681875	125	57	108	25	27	48	4	33	12	1	2.54e-05	0.000159
99	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(3), BFAR(1), BRAF(21), CREB1(1), CREB3(2), CREB5(2), MAPK1(2), RAF1(4), SNX13(6), SRC(3), TERF2IP(1)	2530674	46	32	27	11	7	8	0	26	5	0	2.83e-05	0.000176
100	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	235	ADCYAP1R1(1), ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(4), ADRA2A(3), ADRB1(2), ADRB3(1), AGTR1(3), AGTR2(4), AVPR1A(3), AVPR1B(3), AVPR2(6), BDKRB2(2), BRS3(1), C3AR1(2), C5AR1(2), CALCR(3), CALCRL(5), CCKAR(1), CCKBR(3), CGA(1), CHRM1(3), CHRM2(8), CHRM3(4), CHRM5(1), CNR1(3), CRHR1(1), CRHR2(4), CTSG(2), CYSLTR1(3), CYSLTR2(3), DRD1(1), DRD2(3), DRD3(3), DRD5(2), EDNRA(4), EDNRB(7), F2(2), F2RL2(2), FPR1(2), FSHB(1), FSHR(6), GABBR1(4), GABBR2(3), GABRA1(2), GABRA2(6), GABRA3(4), GABRA4(6), GABRA5(8), GABRA6(4), GABRB1(6), GABRB2(4), GABRB3(5), GABRE(5), GABRG1(7), GABRG2(8), GABRG3(5), GABRP(2), GABRQ(7), GABRR1(2), GABRR2(3), GALR1(1), GH1(1), GH2(1), GHR(6), GHRHR(2), GHSR(5), GLP1R(2), GLP2R(3), GLRA1(2), GLRA2(2), GLRA3(7), GLRB(6), GNRHR(4), GPR156(6), GPR50(5), GPR63(2), GPR83(1), GRIA1(18), GRIA2(10), GRIA3(5), GRIA4(12), GRID1(15), GRID2(10), GRIK1(5), GRIK2(10), GRIK3(15), GRIK4(11), GRIK5(5), GRIN1(1), GRIN2A(15), GRIN2B(8), GRIN2C(2), GRIN2D(3), GRIN3A(3), GRM1(9), GRM2(3), GRM3(5), GRM4(7), GRM5(8), GRM6(9), GRM7(8), GRM8(7), GRPR(3), GZMA(2), HCRTR1(1), HCRTR2(1), HRH1(1), HRH2(4), HRH4(2), HTR1A(3), HTR1B(3), HTR1D(2), HTR1E(5), HTR1F(2), HTR2A(2), HTR2B(1), HTR2C(6), HTR4(2), HTR5A(2), HTR7(6), LEP(1), LEPR(5), LHB(1), LHCGR(4), MAS1(1), MC2R(2), MC3R(1), MC4R(3), MC5R(4), MCHR1(6), MCHR2(2), MLNR(3), MTNR1B(3), NMUR1(4), NMUR2(6), NPBWR1(3), NPFFR2(3), NPY1R(4), NPY2R(5), NPY5R(1), NR3C1(3), NTSR1(1), NTSR2(4), OPRD1(1), OPRK1(5), OPRM1(1), OXTR(2), P2RX1(1), P2RX2(1), P2RX3(2), P2RX4(2), P2RX5(1), P2RX7(2), P2RY1(3), P2RY10(6), P2RY13(2), P2RY14(4), P2RY2(2), P2RY4(6), PARD3(5), PPYR1(1), PRL(2), PRLR(2), PRSS1(3), PRSS2(1), PRSS3(4), PTAFR(1), PTGER2(1), PTGER3(6), PTGFR(6), PTGIR(1), PTH2R(6), RXFP1(2), RXFP2(8), SCTR(3), SSTR1(4), SSTR2(2), SSTR4(2), TAAR1(3), TAAR2(2), TAAR5(5), TAAR6(2), TAAR8(1), TAAR9(1), TACR1(2), TACR2(1), TACR3(4), THRA(2), THRB(4), TRHR(6), TRPV1(3), TSHR(6), VIPR1(3), VIPR2(3)	49151894	750	126	745	274	292	163	17	217	61	0	4.15e-05	0.000256
101	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(2), ACTB(2), ACTN1(3), ACTN2(7), ACTN3(2), ACTN4(2), ACVR1B(13), ACVR1C(2), CDH1(4), CREBBP(21), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTNNA1(10), CTNNA2(10), CTNNA3(9), CTNNB1(8), CTNND1(5), EGFR(10), EP300(13), ERBB2(6), FARP2(5), FER(4), FGFR1(3), FYN(4), IGF1R(7), INSR(5), IQGAP1(10), LEF1(4), LMO7(18), MAP3K7(2), MAPK1(2), MAPK3(2), MET(4), MLLT4(3), NLK(1), PARD3(5), PTPN1(4), PTPN6(4), PTPRB(4), PTPRF(8), PTPRJ(3), PTPRM(19), PVRL1(4), PVRL2(3), PVRL3(1), PVRL4(4), RHOA(4), SMAD2(11), SMAD3(6), SMAD4(21), SNAI1(1), SNAI2(1), SORBS1(7), SRC(3), SSX2IP(3), TCF7(3), TCF7L1(3), TCF7L2(13), TGFBR1(6), TGFBR2(7), TJP1(5), VCL(1), WAS(1), WASF1(1), WASF2(2), WASF3(2), WASL(5), YES1(1)	26187357	377	93	366	100	133	99	5	91	48	1	4.90e-05	0.000299
102	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(2), GABRA2(6), GABRA3(4), GABRA4(6), GABRA5(8), GABRA6(4), GPX1(1), PRKCE(4)	1646935	35	25	34	5	12	7	0	12	4	0	5.23e-05	0.000316
103	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(2), AKT2(5), BAD(1), BCR(6), BTK(6), CD19(3), CSK(1), DAG1(4), EPHB2(7), GRB2(2), ITPKB(4), LYN(4), MAP2K1(3), MAPK1(2), NFAT5(5), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PIK3CA(33), PIK3CD(2), PIK3R1(5), PLCG2(9), PPP1R13B(5), RAF1(4), SERPINA4(2), SHC1(3), SOS1(5), SOS2(9), VAV1(11)	11683483	151	66	132	34	52	43	8	36	12	0	5.58e-05	0.000334
104	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(8), GABRA1(2), GABRA2(6), GABRA3(4), GABRA4(6), GABRA5(8), GABRA6(4), GPHN(11), NSF(1), SRC(3), UBQLN1(2)	2664752	55	33	52	20	16	11	1	19	8	0	7.25e-05	0.000429
105	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(2), AKT2(5), BAD(1), BCL2(1), GRB2(2), GSK3A(2), GSK3B(7), IL4R(1), IRS1(5), JAK1(3), JAK3(6), MAP4K1(2), MAPK1(2), MAPK3(2), PIK3CA(33), PIK3CD(2), PIK3R1(5), PPP1R13B(5), RAF1(4), SHC1(3), SOS1(5), SOS2(9), STAT6(2)	8086815	109	55	91	21	29	35	4	27	14	0	8.17e-05	0.000479
106	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(1), ACTR3(2), AKT1(2), ANGPTL2(8), DAG1(4), DGKA(1), ETFA(2), ITGA9(4), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), MAP2K1(3), MAPK1(2), MAPK3(2), NR1I3(2), PAK1(4), PDE3A(5), PDE3B(2), PIK3C2G(7), PIK3CA(33), PIK3CD(2), PIK3R1(5), PLDN(1), RIPK3(4), RPS4X(1), VASP(3)	10373325	138	61	123	35	43	40	7	30	18	0	8.70e-05	0.000505
107	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT1(2), AKT2(5), BAD(1), BTK(6), CDKN2A(1), DAPP1(1), GRB2(2), GSK3A(2), GSK3B(7), IARS(5), IGFBP1(2), INPP5D(2), PIK3CA(33), PPP1R13B(5), PTEN(6), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KB1(3), SHC1(3), SOS1(5), SOS2(9), TEC(1), YWHAB(2), YWHAE(3), YWHAQ(1)	7890463	119	51	102	22	32	36	4	32	14	1	0.000101	0.000579
108	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(4), EIF2B1(2), EIF2B3(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), ELAVL1(3), FLT1(9), FLT4(4), HIF1A(1), KDR(8), NOS3(2), PIK3CA(33), PIK3R1(5), PLCG1(4), PRKCA(2), PTK2(5), SHC1(3)	7572875	94	52	78	22	24	34	3	22	11	0	0.000150	0.000856
109	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(1), ACTR3(2), AKT1(2), AKT2(5), ANGPTL2(8), ARHGAP4(1), ARHGEF11(9), BTK(6), CFL1(1), GDI1(1), GDI2(1), INPPL1(3), ITPR1(11), ITPR2(12), ITPR3(11), LIMK1(4), MYLK(11), MYLK2(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PIK3CA(33), PIK3CD(2), PIK3CG(12), PIK3R1(5), PITX2(2), PPP1R13B(5), PTEN(6), RACGAP1(2), RHO(2), ROCK1(8), ROCK2(2), RPS4X(1), SAG(1), WASF1(1), WASL(5)	15142989	192	71	176	53	59	53	7	52	20	1	0.000269	0.00152
110	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(2), AKT2(5), GRB2(2), IARS(5), IL13RA1(1), IL4(3), IL4R(1), INPP5D(2), JAK1(3), JAK2(6), JAK3(6), PIK3CA(33), PPP1R13B(5), RPS6KB1(3), SERPINA4(2), SHC1(3), SOS1(5), SOS2(9), SRC(3), STAT6(2), TYK2(1)	8089937	102	52	85	30	26	31	5	29	10	1	0.000383	0.00214
111	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	146	AKT1(2), AKT2(5), BCL2L1(1), CBL(2), CBLB(6), CCND2(1), CCND3(1), CNTF(2), CNTFR(2), CREBBP(21), CSF2RB(7), CSF3R(9), EP300(13), GH1(1), GH2(1), GHR(6), GRB2(2), IFNA1(1), IFNA10(1), IFNA13(2), IFNA16(4), IFNA2(3), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(2), IFNGR2(1), IL10(1), IL10RA(1), IL10RB(4), IL11(1), IL11RA(1), IL12B(2), IL12RB1(2), IL12RB2(5), IL13(1), IL13RA1(1), IL13RA2(2), IL15(1), IL15RA(1), IL19(1), IL2(3), IL20(2), IL20RA(4), IL21(2), IL21R(3), IL22(2), IL22RA1(1), IL23R(2), IL24(2), IL26(3), IL28RA(3), IL2RA(2), IL2RB(1), IL3(3), IL4(3), IL4R(1), IL5RA(4), IL6(1), IL6R(2), IL6ST(2), IL7(1), IL7R(2), IL9(1), IRF9(3), JAK1(3), JAK2(6), JAK3(6), LEP(1), LEPR(5), LIFR(19), MPL(1), OSM(1), OSMR(4), PIAS1(3), PIAS2(2), PIAS3(4), PIAS4(1), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PIM1(1), PRL(2), PRLR(2), PTPN11(2), PTPN6(4), SOCS2(2), SOCS5(2), SOS1(5), SOS2(9), SPRED1(6), SPRED2(5), SPRY1(2), SPRY4(2), STAM(1), STAM2(2), STAT1(6), STAT2(5), STAT3(2), STAT5B(2), STAT6(2), TPO(8), TSLP(2), TYK2(1)	31703264	375	95	355	97	127	89	12	107	39	1	0.000417	0.00231
112	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(2), AKT2(5), BCR(6), BTK(6), CD19(3), CDKN2A(1), DAPP1(1), FLOT1(3), GAB1(6), ITPR1(11), ITPR2(12), ITPR3(11), LYN(4), PHF11(2), PIK3CA(33), PITX2(2), PLCG2(9), PPP1R13B(5), PREX1(14), PTEN(6), PTPRC(9), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KB1(3), SAG(1), TEC(1), VAV1(11)	11851578	179	63	161	47	63	52	5	41	17	1	0.000529	0.00291
113	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(3), ACVR1B(13), ACVR1C(2), ACVR2A(9), ACVR2B(3), ACVRL1(3), AMHR2(2), BMP4(1), BMP5(4), BMP6(3), BMP7(5), BMP8A(1), BMPR1A(4), BMPR1B(9), BMPR2(7), CHRD(5), COMP(2), CREBBP(21), CUL1(7), DCN(3), E2F4(1), E2F5(2), EP300(13), FST(2), GDF5(1), GDF6(2), IFNG(1), INHBA(8), INHBB(1), INHBC(2), LTBP1(8), MAPK1(2), MAPK3(2), NODAL(1), PITX2(2), PPP2CA(1), PPP2R1A(4), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(3), RBL1(3), RBL2(8), RHOA(4), ROCK1(8), ROCK2(2), RPS6KB1(3), RPS6KB2(1), SKP1(1), SMAD1(2), SMAD2(11), SMAD3(6), SMAD4(21), SMAD9(2), SMURF1(1), SMURF2(2), SP1(2), TFDP1(4), TGFB1(1), TGFB2(5), TGFBR1(6), TGFBR2(7), THBS1(8), THBS2(10), THBS3(2), THBS4(1), ZFYVE16(9), ZFYVE9(6)	22247543	302	80	291	99	100	78	6	67	50	1	0.000756	0.00412
114	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(27), CDC25A(2), CDC25B(5), CDC25C(3), CHEK1(1), MYT1(8), WEE1(3)	3143314	49	31	49	4	10	12	0	17	9	1	0.00127	0.00687
115	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(3), AGT(4), AKT1(2), CAMK1(1), CAMK1G(3), CAMK4(2), CREBBP(21), CSNK1A1(2), EDN1(1), ELSPBP1(1), F2(2), GATA4(1), GSK3B(7), HAND1(1), HAND2(1), IGF1(2), MAP2K1(3), MAPK1(2), MAPK14(3), MAPK3(2), MAPK8(2), MEF2C(7), MYH2(9), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NKX2-5(1), NPPA(1), PIK3CA(33), PIK3R1(5), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), RAF1(4), RPS6KB1(3), SYT1(1)	11012280	157	60	141	33	48	53	5	32	19	0	0.00149	0.00801
116	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(3), HLA-DRA(4), HLA-DRB1(1), IL3(3)	661548	11	11	10	2	5	1	0	3	0	2	0.00166	0.00882
117	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(2), CABIN1(9), CAMK1(1), CAMK1G(3), HDAC5(1), IGF1(2), IGF1R(7), INSR(5), MAP2K6(2), MAPK14(3), MAPK7(3), MEF2A(3), MEF2C(7), MEF2D(1), NFATC1(1), NFATC2(3), PIK3CA(33), PIK3R1(5), PPP3CA(1), PPP3CB(4), PPP3CC(3), SYT1(1)	7569683	100	51	85	28	36	31	3	20	10	0	0.00176	0.00928
118	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(2), BAD(1), BCL2(1), BCL2L1(1), CBL(2), CFLAR(2), CRKL(2), GRB2(2), IL2RA(2), IL2RB(1), IRS1(5), JAK1(3), JAK3(6), MAPK1(2), MAPK3(2), NMI(1), PIK3CA(33), PIK3R1(5), PTPN6(4), RAF1(4), RPS6KB1(3), SHC1(3), SOS1(5), STAT5B(2)	7964822	94	49	76	24	26	31	4	25	8	0	0.00201	0.0105
119	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(2), INPP1(2), INPP4A(2), INPP4B(5), INPP5A(2), INPPL1(3), ITPKB(4), MIOX(1), OCRL(5), PIK3C2A(2), PIK3C2B(3), PIK3C2G(7), PIK3CA(33), PIK3CB(2), PIK3CG(12), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PLCD1(6), PLCG1(4), PLCG2(9)	9793430	127	56	111	24	46	41	3	29	8	0	0.00220	0.0114
120	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT1(2), AKT2(5), CASP8(11), CD14(1), CHUK(4), CXCL11(2), CXCL9(2), IFNA1(1), IFNA10(1), IFNA13(2), IFNA16(4), IFNA2(3), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(1), IFNB1(1), IKBKB(2), IKBKE(3), IL12B(2), IL6(1), IRAK1(1), IRAK4(2), IRF5(3), LBP(1), LY96(2), MAP2K1(3), MAP2K3(2), MAP2K4(9), MAP2K6(2), MAP3K7(2), MAP3K8(2), MAPK1(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK3(2), MAPK8(2), MAPK9(3), MYD88(1), NFKB1(3), NFKB2(2), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), RELA(2), RIPK1(2), SPP1(1), STAT1(6), TBK1(5), TICAM1(1), TIRAP(1), TLR1(2), TLR2(2), TLR3(4), TLR4(7), TLR5(3), TLR6(2), TLR7(4), TLR8(3), TLR9(4), TOLLIP(1), TRAF3(4), TRAF6(4)	19987046	227	75	210	58	54	64	12	71	26	0	0.00232	0.0119
121	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(2), AKT2(5), BRD4(4), CBL(2), CDKN2A(1), F2RL2(2), FLOT1(3), GRB2(2), GSK3A(2), GSK3B(7), IGFBP1(2), INPPL1(3), IRS1(5), IRS4(11), LNPEP(6), MAPK1(2), MAPK3(2), PARD3(5), PIK3CA(33), PIK3CD(2), PIK3R1(5), PPYR1(1), PTEN(6), PTPN1(4), RAF1(4), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KB1(3), SERPINB6(1), SHC1(3), SLC2A4(3), SORBS1(7), SOS1(5), SOS2(9), YWHAB(2), YWHAE(3), YWHAQ(1)	13157747	170	64	151	43	49	48	5	50	17	1	0.00257	0.0131
122	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP3(1), CASP8(11), CFL1(1), CFLAR(2), PDE6D(1)	864843	17	16	16	2	3	3	1	6	4	0	0.00272	0.0137
123	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(21), EP300(13), ESR1(12), MAPK1(2), MAPK3(2), PELP1(2), SRC(3)	3251889	55	34	55	13	18	20	1	9	7	0	0.00324	0.0162
124	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(2), AKT2(5), BAD(1), BCL2(1), BCR(6), BTK(6), CD19(3), CD22(8), CR2(9), CSK(1), DAG1(4), FLOT1(3), GRB2(2), GSK3A(2), GSK3B(7), INPP5D(2), ITPR1(11), ITPR2(12), ITPR3(11), LYN(4), MAP4K1(2), MAPK1(2), MAPK3(2), NFATC1(1), NFATC2(3), PIK3CA(33), PIK3CD(2), PIK3R1(5), PLCG2(9), PPP1R13B(5), PPP3CA(1), PPP3CB(4), PPP3CC(3), PTPRC(9), RAF1(4), SHC1(3), SOS1(5), SOS2(9), VAV1(11)	15918486	213	69	195	49	73	58	8	49	25	0	0.00332	0.0165
125	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(4), ACTN1(3), ACTR2(1), ACTR3(2), AKT1(2), AKT2(5), ANGPTL2(8), ARHGEF6(7), ARHGEF7(8), BRAF(21), CDKN2A(1), CSE1L(4), DOCK1(5), EPHB2(7), FYN(4), GRB2(2), GRB7(1), GRLF1(7), ITGA1(3), ITGA10(3), ITGA11(2), ITGA2(5), ITGA3(4), ITGA4(3), ITGA5(7), ITGA6(3), ITGA7(6), ITGA8(5), ITGA9(4), ITGB3BP(1), MAP2K4(9), MAP3K11(4), MAPK1(2), MAPK10(4), MAPK8(2), MAPK8IP1(2), MAPK8IP3(1), MAPK9(3), MRAS(1), MYLK(11), MYLK2(2), P4HB(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PIK3CA(33), PIK3CB(2), PLCG1(4), PLCG2(9), PTEN(6), PTK2(5), RAF1(4), RHO(2), ROCK1(8), ROCK2(2), SHC1(3), SOS1(5), SOS2(9), SRC(3), TERF2IP(1), TLN1(5), TLN2(5), VASP(3), WAS(1)	26932706	305	87	265	93	94	78	8	90	34	1	0.00344	0.0169
126	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(2), ACTN1(3), ACTN2(7), ACTN3(2), ACTN4(2), AKT1(2), AKT2(5), ARHGAP5(6), BAD(1), BCL2(1), BIRC2(2), BIRC3(2), BRAF(21), CAPN2(5), CAV2(1), CAV3(2), CCND2(1), CCND3(1), CHAD(6), COL11A1(18), COL11A2(10), COL1A1(11), COL1A2(16), COL2A1(8), COL3A1(10), COL4A1(12), COL4A2(3), COL4A4(8), COL4A6(15), COL5A1(13), COL5A2(10), COL5A3(5), COL6A3(31), COL6A6(15), COMP(2), CRKL(2), CTNNB1(8), DIAPH1(1), DOCK1(5), EGF(3), EGFR(10), ERBB2(6), FARP2(5), FLNA(2), FLNB(14), FLNC(11), FLT1(9), FN1(17), FYN(4), GRB2(2), GRLF1(7), GSK3B(7), HGF(5), IBSP(3), IGF1(2), IGF1R(7), ITGA1(3), ITGA10(3), ITGA11(2), ITGA2(5), ITGA2B(2), ITGA3(4), ITGA4(3), ITGA5(7), ITGA6(3), ITGA7(6), ITGA8(5), ITGA9(4), ITGAV(1), ITGB1(6), ITGB3(7), ITGB4(2), ITGB5(5), ITGB6(6), ITGB7(4), ITGB8(4), KDR(8), LAMA1(22), LAMA2(22), LAMA3(12), LAMA4(9), LAMB1(8), LAMB2(2), LAMB3(9), LAMB4(12), LAMC1(7), LAMC2(7), LAMC3(6), MAP2K1(3), MAPK1(2), MAPK10(4), MAPK3(2), MAPK8(2), MAPK9(3), MET(4), MYL2(1), MYL7(1), MYLK(11), MYLK2(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PARVA(1), PARVB(5), PARVG(3), PDGFA(1), PDGFC(2), PDGFD(3), PDGFRA(13), PDGFRB(5), PDPK1(1), PGF(1), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PIP5K1C(3), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PRKCA(2), PRKCG(8), PTEN(6), PTK2(5), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF1(4), RELN(24), RHOA(4), ROCK1(8), ROCK2(2), SHC1(3), SHC3(1), SHC4(5), SOS1(5), SOS2(9), SPP1(1), SRC(3), THBS1(8), THBS2(10), THBS3(2), THBS4(1), TLN1(5), TLN2(5), TNC(13), TNN(15), TNR(19), TNXB(14), VASP(3), VAV1(11), VAV2(2), VAV3(10), VCL(1), VEGFA(2), VEGFB(2), VEGFC(3), VTN(3), VWF(10)	81770499	978	133	936	333	339	235	23	274	105	2	0.00437	0.0214
127	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QB(1), C1R(2), C1S(3), C3(10), C5(9), C6(10), C7(2), C8A(3), C8B(9), C9(4), MASP1(9)	4640251	62	35	62	21	20	12	1	20	8	1	0.00460	0.0223
128	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	247	ACVR1(3), ACVR1B(13), ACVR2A(9), ACVR2B(3), AMHR2(2), BMP7(5), BMPR1A(4), BMPR1B(9), BMPR2(7), CCL13(1), CCL15(1), CCL18(1), CCL23(2), CCL27(3), CCL7(1), CCL8(1), CCR1(5), CCR3(3), CCR5(1), CCR6(2), CCR7(1), CCR8(4), CCR9(4), CD27(3), CD40LG(6), CD70(5), CNTF(2), CNTFR(2), CSF1(1), CSF1R(3), CSF2RB(7), CSF3R(9), CX3CR1(1), CXCL11(2), CXCL12(1), CXCL14(1), CXCL5(1), CXCL6(1), CXCL9(2), CXCR4(3), EDA(1), EDA2R(2), EDAR(1), EGF(3), EGFR(10), FASLG(1), FLT1(9), FLT3(3), FLT3LG(1), FLT4(4), GDF5(1), GH1(1), GH2(1), GHR(6), HGF(5), IFNA1(1), IFNA10(1), IFNA13(2), IFNA16(4), IFNA2(3), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(2), IFNGR2(1), IL10(1), IL10RA(1), IL10RB(4), IL11(1), IL11RA(1), IL12B(2), IL12RB1(2), IL12RB2(5), IL13(1), IL13RA1(1), IL15(1), IL15RA(1), IL17A(1), IL17RA(5), IL17RB(1), IL18R1(8), IL18RAP(2), IL19(1), IL1A(1), IL1R1(3), IL1R2(3), IL2(3), IL20(2), IL20RA(4), IL21(2), IL21R(3), IL22(2), IL22RA1(1), IL23R(2), IL24(2), IL25(1), IL26(3), IL28RA(3), IL2RA(2), IL2RB(1), IL3(3), IL4(3), IL4R(1), IL5RA(4), IL6(1), IL6R(2), IL6ST(2), IL7(1), IL7R(2), IL9(1), INHBA(8), INHBB(1), INHBC(2), KDR(8), KIT(6), KITLG(2), LEP(1), LEPR(5), LIFR(19), LTB(1), LTBR(2), MET(4), MPL(1), NGFR(2), OSM(1), OSMR(4), PDGFC(2), PDGFRA(13), PDGFRB(5), PLEKHO2(5), PRL(2), PRLR(2), RELT(2), TGFB1(1), TGFB2(5), TGFBR1(6), TGFBR2(7), TNFRSF10A(3), TNFRSF10B(2), TNFRSF10C(6), TNFRSF11A(2), TNFRSF11B(4), TNFRSF13B(4), TNFRSF17(2), TNFRSF19(3), TNFRSF1A(1), TNFRSF21(4), TNFRSF4(1), TNFRSF8(1), TNFRSF9(2), TNFSF10(1), TNFSF11(1), TNFSF12(2), TNFSF13(2), TNFSF14(3), TNFSF15(3), TNFSF18(1), TNFSF4(1), TNFSF8(1), TPO(8), TSLP(2), VEGFA(2), VEGFB(2), VEGFC(3), XCL2(1)	39232184	495	101	484	162	161	110	10	147	66	1	0.00477	0.0230
129	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	163	ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(4), ADRA1D(2), ADRA2A(3), ADRB1(2), ADRB3(1), AGTR1(3), AGTR2(4), AVPR1A(3), AVPR1B(3), AVPR2(6), BDKRB2(2), BRS3(1), C3AR1(2), CCBP2(5), CCKAR(1), CCKBR(3), CCR1(5), CCR3(3), CCR5(1), CCR6(2), CCR7(1), CCR8(4), CCR9(4), CCRL1(2), CHML(4), CHRM1(3), CHRM2(8), CHRM3(4), CHRM5(1), CMKLR1(2), CNR1(3), CX3CR1(1), CXCR4(3), DRD1(1), DRD2(3), DRD3(3), DRD5(2), EDNRA(4), EDNRB(7), F2RL2(2), FPR1(2), FSHR(6), GALR1(1), GALT(2), GHSR(5), GPR17(1), GPR173(2), GPR174(2), GPR37(6), GPR37L1(3), GPR4(1), GPR50(5), GPR6(5), GPR63(2), GPR77(1), GPR83(1), GPR85(1), GPR87(4), GRPR(3), HCRTR1(1), HCRTR2(1), HRH1(1), HRH2(4), HTR1A(3), HTR1B(3), HTR1D(2), HTR1E(5), HTR1F(2), HTR2A(2), HTR2B(1), HTR2C(6), HTR4(2), HTR5A(2), HTR7(6), LHCGR(4), MAS1(1), MC3R(1), MC4R(3), MC5R(4), MLNR(3), MTNR1B(3), NMUR1(4), NMUR2(6), NPY1R(4), NPY2R(5), NPY5R(1), NTSR1(1), NTSR2(4), OPN1SW(3), OPN3(1), OPRD1(1), OPRK1(5), OPRM1(1), OR12D3(1), OR1C1(1), OR1F1(2), OR2H1(3), OR5V1(2), OR7A5(3), OR7C1(6), OR8B8(2), OXTR(2), P2RY1(3), P2RY10(6), P2RY12(3), P2RY13(2), P2RY14(4), P2RY2(2), PPYR1(1), PTAFR(1), PTGER2(1), PTGFR(6), PTGIR(1), RGR(2), RHO(2), RRH(2), SSTR1(4), SSTR2(2), SSTR4(2), TRHR(6)	26455117	356	94	357	124	147	86	6	90	27	0	0.00520	0.0248
130	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(2), AKT2(5), BAD(1), BCL2L1(1), CDK2(2), CDKN1B(1), CDKN2A(1), CREB1(1), CREB3(2), CREB5(2), EBP(2), ERBB4(16), F2RL2(2), GAB1(6), GRB2(2), GSK3A(2), GSK3B(7), IGF1(2), IGFBP1(2), INPPL1(3), IRS1(5), IRS4(11), MET(4), NOLC1(7), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PARD3(5), PIK3CA(33), PIK3CD(2), PPP1R13B(5), PREX1(14), PTEN(6), PTK2(5), PTPN1(4), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KB1(3), SHC1(3), SLC2A4(3), SOS1(5), SOS2(9), TSC1(3), TSC2(1), YWHAB(2), YWHAE(3), YWHAQ(1)	17085398	222	71	203	71	66	60	6	65	24	1	0.00527	0.0250
131	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(2), CD28(1), CD3D(1), CSK(1), CTLA4(1), DAG1(4), EPHB2(7), FBXW7(33), GRAP2(2), GRB2(2), ITK(8), ITPKB(4), LCK(2), LCP2(2), MAPK1(2), NFAT5(5), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PLCG1(4), PTPRC(9), RAF1(4), RASGRP1(2), RASGRP2(5), RASGRP3(4), RASGRP4(1), SOS1(5), SOS2(9), VAV1(11), ZAP70(4)	12344726	157	61	142	50	64	30	8	40	15	0	0.00584	0.0273
132	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), BAX(1), BCL2(1), CASP8(11), MAP2K1(3), MAP2K4(9), MAP3K1(6), MAPK1(2), MAPK3(2), MAPK8(2), NFKB1(3), NSMAF(1), RAF1(4), RELA(2), RIPK1(2), SMPD1(6), TNFRSF1A(1), TRADD(1), TRAF2(1)	4608660	59	37	56	10	22	16	4	9	8	0	0.00586	0.0273
133	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(2), AKT2(5), BRAF(21), EIF4B(1), HIF1A(1), IGF1(2), MAPK1(2), MAPK3(2), PDPK1(1), PGF(1), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PRKAA1(2), PRKAA2(6), RICTOR(10), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KA6(5), RPS6KB1(3), RPS6KB2(1), TSC1(3), TSC2(1), ULK2(4), ULK3(3), VEGFA(2), VEGFB(2), VEGFC(3)	11809318	151	59	117	29	39	40	3	53	16	0	0.00707	0.0328
134	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1B(2), ADH1C(3), ADH4(1), ADH6(5), ADH7(2), ADHFE1(6)	1229065	19	16	19	5	3	4	1	11	0	0	0.00737	0.0339
135	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(3), CFL1(1), GNAQ(3), GNAS(6), GNB1(1), LIMK1(4), MAP2K1(3), MAPK1(2), MAPK3(2), MYL2(1), NOX1(1), PIK3C2G(7), PLCB1(8), PPP1R12B(5), PRKCA(2), PTK2(5), RAF1(4), ROCK2(2)	5505383	60	39	58	11	24	8	2	17	9	0	0.00785	0.0358
136	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(2), C1GALT1C1(2), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(1), GALNT13(5), GALNT14(9), GALNT2(3), GALNT3(4), GALNT5(6), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(2), GALNTL1(3), GALNTL2(6), GALNTL4(1), GALNTL5(5), GCNT1(3), GCNT3(2), GCNT4(5), OGT(4), ST3GAL1(1), ST3GAL2(1), ST6GALNAC1(2), WBSCR17(17)	7291656	100	47	99	24	42	22	2	19	15	0	0.00910	0.0412
137	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(5), ADRA1B(4), ADRA1D(2), ADRA2A(3), ADRB1(2), ADRB3(1), CHRM1(3), CHRM2(8), CHRM3(4), CHRM5(1), DRD1(1), DRD2(3), DRD3(3), DRD5(2), HRH1(1), HRH2(4), HTR1A(3), HTR1B(3), HTR1D(2), HTR1E(5), HTR1F(2), HTR2A(2), HTR2B(1), HTR2C(6), HTR4(2), HTR5A(2), HTR7(6)	5598144	81	46	81	31	37	22	1	12	9	0	0.00920	0.0414
138	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	ALCAM(2), CADM1(8), CADM3(6), CD2(3), CD22(8), CD226(2), CD274(3), CD28(1), CD34(1), CD4(2), CD40LG(6), CD58(1), CD6(3), CD8B(2), CDH1(4), CDH2(16), CDH3(2), CDH4(7), CDH5(2), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(4), CLDN17(5), CLDN18(2), CLDN19(1), CLDN6(2), CLDN7(2), CLDN8(3), CLDN9(1), CNTN1(12), CNTN2(5), CNTNAP1(6), CNTNAP2(8), CTLA4(1), ESAM(3), F11R(1), GLG1(4), HLA-A(1), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DRA(4), HLA-DRB1(1), HLA-E(1), HLA-F(1), HLA-G(1), ICAM1(2), ICAM2(1), ICOS(1), ITGA4(3), ITGA6(3), ITGA8(5), ITGA9(4), ITGAL(5), ITGAM(5), ITGAV(1), ITGB1(6), ITGB2(4), ITGB7(4), ITGB8(4), JAM3(3), L1CAM(2), MAG(5), MPZL1(1), NCAM1(2), NCAM2(9), NEGR1(4), NEO1(4), NFASC(13), NLGN1(4), NLGN2(1), NLGN3(4), NRCAM(6), NRXN1(21), NRXN2(5), NRXN3(16), OCLN(1), PDCD1LG2(1), PECAM1(1), PTPRC(9), PTPRF(8), PTPRM(19), PVR(1), PVRL1(4), PVRL2(3), PVRL3(1), SDC2(2), SDC3(2), SDC4(1), SELE(2), SELP(4), SELPLG(1), SIGLEC1(2), SPN(1), VCAM1(7), VCAN(23)	32973554	405	94	398	153	137	86	6	124	48	4	0.00967	0.0432
139	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(6), AGT(4), AGTR1(3), AGTR2(4), COL4A1(12), COL4A2(3), COL4A3(3), COL4A4(8), COL4A5(17), COL4A6(15), REN(3)	5623215	78	38	77	14	17	23	2	22	14	0	0.0103	0.0455
140	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(2), GALNT10(5), GALNT2(3), GALNT3(4), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(2), GCNT1(3), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2), WBSCR17(17)	3188319	45	30	44	14	20	10	1	5	9	0	0.0122	0.0537
141	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY7(3), ADCY8(11), ADCY9(4), ADORA2A(3), ADORA2B(1), ADRA1A(5), ADRA1B(4), ADRA1D(2), ADRB1(2), ADRB3(1), AGTR1(3), ATP2A1(6), ATP2A2(5), ATP2A3(3), ATP2B1(7), ATP2B2(7), ATP2B3(4), ATP2B4(5), AVPR1A(3), AVPR1B(3), BDKRB2(2), CACNA1A(8), CACNA1B(7), CACNA1C(10), CACNA1D(7), CACNA1E(15), CACNA1F(12), CACNA1G(10), CACNA1H(2), CACNA1I(3), CACNA1S(10), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), CCKAR(1), CCKBR(3), CD38(1), CHRM1(3), CHRM2(8), CHRM3(4), CHRM5(1), CYSLTR1(3), CYSLTR2(3), DRD1(1), EDNRA(4), EDNRB(7), EGFR(10), ERBB2(6), ERBB3(11), ERBB4(16), GNA11(1), GNA14(5), GNA15(3), GNAL(3), GNAQ(3), GNAS(6), GRIN1(1), GRIN2A(15), GRIN2C(2), GRIN2D(3), GRM1(9), GRM5(8), GRPR(3), HRH1(1), HRH2(4), HTR2A(2), HTR2B(1), HTR2C(6), HTR4(2), HTR5A(2), HTR7(6), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), LHCGR(4), MYLK(11), MYLK2(2), NOS1(5), NOS3(2), NTSR1(1), OXTR(2), P2RX1(1), P2RX2(1), P2RX3(2), P2RX4(2), P2RX5(1), P2RX7(2), PDE1A(3), PDE1B(2), PDE1C(7), PDGFRA(13), PDGFRB(5), PHKA1(4), PHKA2(5), PHKB(4), PHKG2(2), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PLCD1(6), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(4), PLCG2(9), PLCZ1(3), PPID(2), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRKACB(1), PRKACG(2), PRKCA(2), PRKCG(8), PRKX(2), PTAFR(1), PTGER3(6), PTGFR(6), PTK2B(1), RYR1(19), RYR2(48), RYR3(31), SLC25A4(1), SLC25A5(1), SLC8A1(11), SLC8A2(3), SLC8A3(4), SPHK2(1), TACR1(2), TACR2(1), TACR3(4), TNNC2(1), TRHR(6), TRPC1(5), VDAC1(1), VDAC3(1)	57440702	727	123	721	290	302	167	17	180	59	2	0.0138	0.0603
142	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(4), CREM(4), FHL5(1), FSHB(1), FSHR(6), GNAS(6), XPO1(1)	2121753	23	20	23	8	9	5	2	5	2	0	0.0151	0.0653
143	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	48	ACOX1(3), APOA2(1), CD36(1), CITED2(1), CPT1B(5), CREBBP(21), DUSP1(2), EHHADH(2), EP300(13), FABP1(1), HSD17B4(3), LPL(6), MAPK1(2), MAPK3(2), ME1(7), NCOA1(6), NCOR1(7), NCOR2(2), NR1H3(4), NR2F1(2), NRIP1(5), PDGFA(1), PIK3CA(33), PIK3R1(5), PPARA(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PTGS2(2), RB1(4), RELA(2), RXRA(1), SP1(2), STAT5B(2)	13924877	158	60	143	42	39	53	5	40	20	1	0.0161	0.0694
144	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(10), GNAS(6), GNB1(1), GRB2(2), IGF1R(7), ITGB1(6), KLK2(3), MAP2K1(3), MAPK1(2), MAPK3(2), MKNK1(1), MKNK2(2), NGFR(2), PDGFRA(13), PPP2CA(1), PTPRR(1), RAF1(4), RPS6KA1(1), RPS6KA5(3), SHC1(3), SOS1(5), SRC(3), STAT3(2)	7538648	83	48	79	30	30	16	6	23	7	1	0.0169	0.0717
145	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(2), ACP2(2), ACP5(1), ACPP(3), ALPI(2), ALPL(1), ALPP(1), CYP19A1(5), CYP1A1(6), CYP1A2(2), CYP2A13(6), CYP2A6(3), CYP2A7(5), CYP2C19(4), CYP2C8(2), CYP2C9(4), CYP2E1(5), CYP2F1(3), CYP2J2(3), CYP3A4(1), CYP3A5(3), CYP3A7(4), CYP4B1(8), CYP4F8(4), CYP51A1(3), PON1(5)	6374104	88	43	87	18	32	18	4	24	9	1	0.0169	0.0717
146	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(27), BMPR1B(9), CCND2(1), CDK4(2), CDKN1B(1), DAZL(1), DMC1(3), EGR1(2), ESR2(2), FSHR(6), GJA4(2), INHA(2), LHCGR(4), MLH1(5), MSH5(4), NCOR1(7), NRIP1(5), PGR(4), PRLR(2), PTGER2(1), SMPD1(6), VDR(1), ZP2(6)	7919356	103	46	103	25	29	23	1	31	18	1	0.0170	0.0719
147	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(3), EGFR(10), ERBB3(11), NRG1(9), UBE2D1(1)	2348873	34	26	31	6	16	7	0	7	4	0	0.0176	0.0739
148	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(3), ANAPC10(2), ANAPC2(1), ANAPC4(1), ANAPC5(2), ANAPC7(4), BTRC(2), CDC16(3), CDC20(3), CDC23(6), CDC27(9), CUL1(7), CUL2(4), CUL3(1), FBXW11(7), FBXW7(33), ITCH(3), SKP1(1), SKP2(1), SMURF1(1), SMURF2(2), UBA1(1), UBE2C(2), UBE2D1(1), UBE2D4(1), UBE2E1(3), WWP1(5), WWP2(4)	9128388	113	53	97	30	40	15	2	36	20	0	0.0186	0.0772
149	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(4), CYP2C9(4)	461019	8	8	8	2	2	1	0	4	1	0	0.0187	0.0772
150	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(3), ACTN2(7), ACTN3(2), ACTN4(2), ARHGAP5(6), CDH5(2), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(4), CLDN17(5), CLDN18(2), CLDN19(1), CLDN6(2), CLDN7(2), CLDN8(3), CLDN9(1), CTNNA1(10), CTNNA2(10), CTNNA3(9), CTNNB1(8), CTNND1(5), CXCL12(1), CXCR4(3), CYBB(1), ESAM(3), EZR(2), F11R(1), GNAI1(3), GRLF1(7), ICAM1(2), ITGA4(3), ITGAL(5), ITGAM(5), ITGB1(6), ITGB2(4), ITK(8), JAM3(3), MAPK12(2), MAPK14(3), MLLT4(3), MMP2(2), MMP9(6), MSN(3), MYL2(1), MYL7(1), NCF1(1), NCF2(1), NCF4(2), NOX1(1), NOX3(5), OCLN(1), PECAM1(1), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLCG1(4), PLCG2(9), PRKCA(2), PRKCG(8), PTK2(5), PTK2B(1), PTPN11(2), RAP1A(1), RAP1B(2), RAPGEF3(3), RAPGEF4(7), RASSF5(3), RHOA(4), RHOH(2), ROCK1(8), ROCK2(2), SIPA1(1), TXK(4), VASP(3), VAV1(11), VAV2(2), VAV3(10), VCAM1(7), VCL(1)	27302008	336	86	316	88	127	80	7	80	42	0	0.0201	0.0817
151	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(20), MAP2(21), PPP2CA(1), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAR2B(2), PRKCE(4)	4045327	52	31	52	13	16	11	1	14	10	0	0.0202	0.0817
152	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(6), ERBB4(16), NRG2(4), NRG3(3), PRKCA(2), PSEN1(3)	2064968	34	22	34	8	7	10	0	13	4	0	0.0202	0.0817
153	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(3), FMOD(2), KERA(5), LUM(5)	806504	15	13	15	3	4	6	0	3	2	0	0.0204	0.0821
154	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(3), GNAQ(3), GNB1(1), HTR2C(6), PLCB1(8), TUB(4)	1619755	25	18	25	7	13	3	1	5	3	0	0.0215	0.0859
155	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(8), BDKRB2(2), C1QB(1), C1QC(3), C1R(2), C1S(3), C3(10), C3AR1(2), C4BPA(2), C5(9), C5AR1(2), C6(10), C7(2), C8A(3), C8B(9), C9(4), CD46(2), CD55(3), CFB(2), CFH(10), CFI(2), CPB2(1), CR1(7), CR2(9), F10(1), F11(4), F12(2), F13A1(8), F13B(3), F2(2), F3(1), F5(14), F7(2), F8(15), F9(6), FGA(11), FGB(1), FGG(4), KLKB1(4), KNG1(3), MASP1(9), MASP2(4), PLAT(4), PLAU(2), PLAUR(3), PLG(7), PROC(1), PROS1(3), SERPINA5(3), SERPINC1(3), SERPIND1(1), SERPINE1(1), SERPING1(3), THBD(2), VWF(10)	20034256	245	72	242	84	70	64	5	79	26	1	0.0225	0.0894
156	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(10), C5(9), C6(10), C7(2), C8A(3), C9(4)	2805116	38	23	38	11	12	9	0	12	4	1	0.0250	0.0988
157	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(2), HLA-DRA(4), HLA-DRB1(1), IL10(1), IL2(3), IL4(3)	890834	15	12	15	8	6	4	0	3	0	2	0.0275	0.108
158	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(3), AGTR2(4), ATP8A1(5), AVPR1A(3), AVPR1B(3), AVPR2(6), BDKRB2(2), BRS3(1), C3AR1(2), CCKAR(1), CCKBR(3), CCR1(5), CCR3(3), CCR5(1), CCR6(2), CCR7(1), CCR8(4), CX3CR1(1), CXCR4(3), EDNRA(4), EDNRB(7), FPR1(2), FSHR(6), GALR1(1), GALT(2), GHSR(5), GNRHR(4), GPR77(1), GRPR(3), LHCGR(4), MC2R(2), MC3R(1), MC4R(3), MC5R(4), NPY1R(4), NPY2R(5), NPY5R(1), NTSR1(1), NTSR2(4), OPRD1(1), OPRK1(5), OPRM1(1), OXTR(2), PPYR1(1), SSTR1(4), SSTR2(2), SSTR4(2), TAC4(1), TACR1(2), TACR2(1), TACR3(4), TRHR(6), TSHR(6)	11247469	155	61	156	61	58	36	3	50	8	0	0.0346	0.135
159	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), ADRA1A(5), ADRA1B(4), ADRA1D(2), ADRB1(2), ADRB3(1), ANXA6(2), ARRB1(1), ATP1A4(6), ATP1B1(1), ATP2A2(5), ATP2A3(3), ATP2B1(7), ATP2B2(7), ATP2B3(4), CACNA1A(8), CACNA1B(7), CACNA1C(10), CACNA1D(7), CACNA1E(15), CACNA1S(10), CACNB1(1), CACNB3(1), CAMK1(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), CASQ1(1), CASQ2(1), CHRM1(3), CHRM2(8), CHRM3(4), CHRM5(1), GJA1(3), GJA4(2), GJA5(3), GJB1(3), GJB3(3), GJB4(1), GNA11(1), GNAO1(5), GNAQ(3), GNAZ(1), GNB1(1), GNB3(3), GNB4(3), GNB5(1), GNG3(2), GNG7(1), GRK4(5), GRK5(3), GRK6(3), ITPR1(11), ITPR2(12), ITPR3(11), KCNB1(2), KCNJ3(6), KCNJ5(3), NME7(3), PEA15(1), PKIA(1), PKIB(1), PLCB3(3), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(4), PRKCG(8), PRKCH(2), PRKCQ(4), PRKD1(10), RGS1(1), RGS10(1), RGS14(2), RGS16(2), RGS17(1), RGS18(2), RGS2(1), RGS20(3), RGS3(8), RGS4(2), RGS6(3), RGS7(4), RGS9(4), RYR1(19), RYR2(48), RYR3(31), SLC8A1(11), SLC8A3(4), USP5(3), YWHAB(2), YWHAQ(1)	39826433	482	106	480	206	215	101	12	114	39	1	0.0356	0.138
160	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(3), ACVR1B(13), ACVRL1(3), AKT1(2), AURKB(1), BMPR1A(4), BMPR2(7), BUB1(4), CDKL1(2), CDKL2(4), CDS1(1), CDS2(4), CLK1(5), CLK4(2), COL4A3BP(3), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), DGKA(1), DGKB(7), DGKD(9), DGKE(1), DGKG(3), DGKH(5), DGKZ(2), IMPA1(2), INPP1(2), INPP4A(2), INPP4B(5), INPP5A(2), INPPL1(3), ITPKB(4), MAP3K10(2), MOS(2), NEK1(7), NEK3(4), OCRL(5), PIK3C2A(2), PIK3C2B(3), PIK3C2G(7), PIK3CA(33), PIK3CB(2), PIK3CG(12), PIM2(1), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PLCD1(6), PLCG1(4), PLCG2(9), PLK3(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(4), PRKCG(8), PRKCH(2), PRKCQ(4), PRKD1(10), PRKG1(4), RAF1(4), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KB1(3), TGFBR1(6), VRK1(3)	25078686	310	84	291	76	119	83	7	78	23	0	0.0364	0.140
161	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CDO1(1), CSAD(1), GAD1(7), GAD2(4), GGT1(3)	1258083	18	15	16	4	7	6	1	4	0	0	0.0416	0.159
162	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(3), ALDH1A2(6), BCMO1(4), RDH5(1)	874199	14	12	14	1	6	2	1	4	1	0	0.0421	0.160
163	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	109	A4GNT(2), ALG10(3), ALG10B(4), ALG11(1), ALG12(2), ALG13(1), ALG2(3), ALG3(1), ALG6(3), ALG8(5), ALG9(1), B3GNT1(2), B3GNT2(1), B3GNT7(4), B4GALT1(5), B4GALT2(3), B4GALT3(6), B4GALT5(2), C1GALT1C1(2), CHPF(3), CHST1(6), CHST11(2), CHST12(2), CHST13(1), CHST14(1), CHST2(1), CHST4(5), CHSY1(5), DAD1(2), DDOST(2), DPAGT1(1), EXT1(10), EXTL1(3), EXTL2(3), EXTL3(7), FUT8(1), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(1), GALNT13(5), GALNT14(9), GALNT2(3), GALNT3(4), GALNT5(6), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(2), GALNTL1(3), GALNTL2(6), GALNTL4(1), GALNTL5(5), GANAB(4), GCNT1(3), GCNT3(2), GCNT4(5), HS2ST1(3), HS3ST1(1), HS3ST2(1), HS3ST3B1(2), HS3ST5(4), HS6ST2(2), HS6ST3(2), MAN1A1(4), MAN1A2(2), MAN1B1(2), MAN1C1(4), MAN2A1(8), MGAT1(1), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(2), NDST1(3), NDST2(5), NDST3(7), NDST4(4), OGT(4), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(2), STT3B(4), UST(1), WBSCR17(17), XYLT1(4), XYLT2(2)	24502865	289	82	287	80	117	64	8	70	30	0	0.0431	0.162
164	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHAT(6), CHKA(2), PCYT1A(4), PDHA1(4), PDHA2(6), PEMT(1), SLC18A3(6)	1548475	29	20	29	13	11	10	0	6	2	0	0.0432	0.162
165	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3D(1), CD3G(2), IFNG(1), IL2(3), IL2RA(2), IL4(3), TGFB1(1), TGFB2(5), TGFBR1(6), TGFBR2(7), TGFBR3(5), TOB2(1)	2407923	38	21	37	13	16	6	1	9	6	0	0.0439	0.164
166	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(2), HLA-DRA(4), HLA-DRB1(1)	521258	8	8	8	4	2	3	0	1	0	2	0.0443	0.164
167	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BAD(1), BRAF(21), CREB1(1), CREB3(2), CREB5(2), DUSP4(1), DUSP6(4), DUSP9(1), GRB2(2), MAP2K1(3), MAP3K8(2), MAPK1(2), MAPK3(2), MKNK1(1), MKNK2(2), MOS(2), NFKB1(3), RAP1A(1), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), SHC1(3), SOS1(5), SOS2(9), TRAF3(4)	6777854	87	44	68	21	20	16	3	37	11	0	0.0457	0.169
168	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(3), ACTN2(7), ACTN3(2), CSK(1), CTNNA1(10), CTNNA2(10), CTNNB1(8), PECAM1(1), PTK2(5), SRC(3), VCL(1)	4387151	51	33	51	20	26	11	0	8	6	0	0.0503	0.184
169	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(10), AR(4), ESR1(12), ESR2(2), ESRRA(2), HNF4A(2), NR0B1(2), NR1D1(4), NR1D2(3), NR1H3(4), NR1I2(2), NR1I3(2), NR2C2(4), NR2E1(1), NR2F1(2), NR2F2(5), NR3C1(3), NR4A1(2), NR4A2(5), NR5A2(4), PGR(4), PPARA(1), PPARD(1), PPARG(1), RARB(7), RARG(5), ROR1(5), RORA(2), RORC(1), RXRA(1), RXRB(2), RXRG(3), THRA(2), THRB(4), VDR(1)	9434417	115	54	115	46	45	25	2	32	11	0	0.0513	0.187
170	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(5), GABBR1(4), GPRC5A(2), GPRC5B(1), GPRC5C(1), GPRC5D(1), GRM1(9), GRM2(3), GRM3(5), GRM4(7), GRM5(8), GRM7(8), GRM8(7)	4608839	61	37	59	36	29	11	1	14	6	0	0.0526	0.191
171	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	86	AGRN(1), CD36(1), CD44(3), CD47(3), CHAD(6), COL11A1(18), COL11A2(10), COL1A1(11), COL1A2(16), COL2A1(8), COL3A1(10), COL4A1(12), COL4A2(3), COL4A4(8), COL4A6(15), COL5A1(13), COL5A2(10), COL5A3(5), COL6A3(31), COL6A6(15), DAG1(4), FN1(17), FNDC1(15), FNDC3A(5), FNDC4(1), GP1BA(1), GP5(5), GP6(1), HMMR(4), HSPG2(9), IBSP(3), ITGA1(3), ITGA10(3), ITGA11(2), ITGA2(5), ITGA2B(2), ITGA3(4), ITGA4(3), ITGA5(7), ITGA6(3), ITGA7(6), ITGA8(5), ITGA9(4), ITGAV(1), ITGB1(6), ITGB3(7), ITGB4(2), ITGB5(5), ITGB6(6), ITGB7(4), ITGB8(4), LAMA1(22), LAMA2(22), LAMA3(12), LAMA4(9), LAMB1(8), LAMB2(2), LAMB3(9), LAMB4(12), LAMC1(7), LAMC2(7), LAMC3(6), RELN(24), SDC2(2), SDC3(2), SDC4(1), SPP1(1), SV2A(4), SV2B(4), SV2C(4), THBS1(8), THBS2(10), THBS3(2), THBS4(1), TNC(13), TNN(15), TNR(19), TNXB(14), VTN(3), VWF(10)	50004551	599	112	596	234	221	136	11	169	62	0	0.0539	0.194
172	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA1(2), IMPA2(2), INPP1(2), INPP4A(2), INPP4B(5), INPP5A(2), INPP5B(1), INPPL1(3), IPMK(2), ITGB1BP3(1), ITPK1(2), ITPKB(4), MIOX(1), OCRL(5), PI4KA(11), PI4KB(2), PIK3C3(5), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(1), PIP5K1C(3), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PLCD1(6), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(4), PLCG2(9), PLCZ1(3), PTEN(6), PTPMT1(2), SYNJ1(8), SYNJ2(5)	16216573	192	63	173	40	74	52	7	39	18	2	0.0565	0.202
173	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5R1(1), DAB1(4), FYN(4), LRP8(1), RELN(24), VLDLR(3)	3166952	37	25	36	14	10	8	3	11	5	0	0.0567	0.202
174	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(2), B3GNT1(2), FUT1(1), FUT2(1), FUT9(4), GCNT2(9), ST8SIA1(3)	1350762	22	15	22	4	6	6	1	6	3	0	0.0584	0.207
175	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1)	2914856	40	26	40	10	12	11	1	16	0	0	0.0611	0.215
176	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(12), COL4A2(3), COL4A3(3), COL4A4(8), COL4A5(17), COL4A6(15), F10(1), F11(4), F12(2), F2(2), F5(14), F8(15), F9(6), FGA(11), FGB(1), FGG(4), KLKB1(4), PROC(1), PROS1(3), SERPINC1(3), SERPING1(3)	9953487	132	48	129	31	26	35	3	45	23	0	0.0614	0.215
177	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(3), CD4(2), HLA-DRA(4), HLA-DRB1(1), IL4(3), IL5RA(4), IL6(1)	1203207	18	13	18	5	7	3	0	6	0	2	0.0626	0.218
178	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(8), F2(2), FGA(11), FGB(1), FGG(4), PLAT(4), PLAU(2), PLG(7), SERPINB2(4), SERPINE1(1)	3039479	45	28	45	13	12	16	1	11	5	0	0.0631	0.218
179	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(4), BMPR1A(4), BMPR1B(9), BMPR2(7)	1406446	24	16	24	4	5	7	0	5	7	0	0.0648	0.223
180	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(10), EXTL1(3), EXTL2(3), EXTL3(7), GLCE(3), HS2ST1(3), HS3ST1(1), HS3ST2(1), HS3ST3B1(2), HS3ST5(4), HS6ST2(2), HS6ST3(2), NDST1(3), NDST2(5), NDST3(7), NDST4(4)	4602310	60	36	60	16	26	15	2	13	4	0	0.0660	0.225
181	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(2), CHAD(6), COL11A1(18), COL11A2(10), COL17A1(6), COL1A1(11), COL1A2(16), COL2A1(8), COL3A1(10), COL4A1(12), COL4A2(3), COL4A4(8), COL4A6(15), COL5A1(13), COL5A2(10), COL5A3(5), COL6A3(31), COL6A6(15), COMP(2), DES(1), DSC1(7), DSC2(2), DSC3(3), DSG1(6), DSG2(5), DSG3(8), DSG4(5), FN1(17), GJA1(3), GJA10(5), GJA4(2), GJA5(3), GJA8(4), GJA9(3), GJB1(3), GJB3(3), GJB4(1), GJB7(1), GJC1(4), GJC2(1), GJC3(1), GJD4(2), IBSP(3), INA(2), ITGA6(3), ITGB4(2), KRT1(3), KRT10(2), KRT12(1), KRT13(4), KRT15(1), KRT16(2), KRT17(2), KRT18(2), KRT19(2), KRT2(1), KRT23(1), KRT24(1), KRT25(3), KRT27(1), KRT28(1), KRT3(5), KRT31(4), KRT32(1), KRT33A(2), KRT33B(4), KRT34(4), KRT35(1), KRT36(2), KRT37(3), KRT4(2), KRT5(3), KRT6A(3), KRT6B(2), KRT6C(2), KRT7(1), KRT71(3), KRT72(5), KRT73(2), KRT74(2), KRT75(5), KRT76(2), KRT77(1), KRT78(3), KRT79(2), KRT8(1), KRT81(1), KRT82(4), KRT83(1), KRT84(5), KRT85(5), KRT9(4), LAMA1(22), LAMA2(22), LAMA3(12), LAMA4(9), LAMB1(8), LAMB2(2), LAMB3(9), LAMB4(12), LAMC1(7), LAMC2(7), LAMC3(6), LMNB1(2), LMNB2(1), NES(6), PRPH(1), RELN(24), SPP1(1), THBS1(8), THBS2(10), THBS3(2), THBS4(1), TNC(13), TNN(15), TNR(19), TNXB(14), VIM(2), VTN(3), VWF(10)	54560808	661	118	658	247	264	152	9	177	59	0	0.0660	0.225
182	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QB(1), C1R(2), C1S(3), C3(10), C5(9), C6(10), C7(2), C8A(3), C9(4), MASP1(9), MASP2(4)	4746977	57	31	57	22	17	11	2	18	8	1	0.0676	0.229
183	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(2), UGDH(3), UGP2(5), UXS1(6)	1094737	17	14	17	5	7	4	0	4	2	0	0.0711	0.239
184	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), AKR1C2(3), AKR1C4(2), ALDH1A3(4), ALDH3A1(2), ALDH3B1(2), ALDH3B2(1), CYP1A1(6), CYP1A2(2), CYP1B1(2), CYP2C19(4), CYP2C8(2), CYP2C9(4), CYP2E1(5), CYP2F1(3), CYP2S1(3), CYP3A4(1), CYP3A5(3), CYP3A7(4), DHDH(1), EPHX1(5), GSTA1(1), GSTA3(3), GSTA5(1), GSTM2(2), GSTM3(2), GSTM4(2), GSTM5(1), GSTZ1(2), MGST1(2), MGST3(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2A1(8), UGT2A3(5), UGT2B10(1), UGT2B11(4), UGT2B15(2), UGT2B17(4), UGT2B28(2), UGT2B4(2), UGT2B7(4)	12103139	143	52	142	33	39	30	4	52	17	1	0.0724	0.242
185	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(12), COL4A2(3), COL4A3(3), COL4A4(8), COL4A5(17), COL4A6(15), P4HB(2), SLC23A1(2), SLC23A2(6), SLC2A3(1)	5543856	69	34	68	15	16	17	2	20	14	0	0.0732	0.243
186	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), HLA-DRA(4), HLA-DRB1(1), IFNG(1), IFNGR1(2), IFNGR2(1), IL12B(2), IL12RB1(2), IL12RB2(5), IL18R1(8), IL2(3), IL2RA(2), IL4(3), IL4R(1)	2810347	36	22	36	13	12	10	0	10	2	2	0.0734	0.243
187	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(3), ACTA2(3), ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), ADM(2), ARRB1(1), ATF1(1), ATF3(1), ATP2A2(5), ATP2A3(3), CACNB3(1), CALCA(4), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CORIN(10), CREB3(2), CRHR1(1), DGKZ(2), ETS2(2), GABPA(4), GABPB2(2), GBA2(5), GJA1(3), GNAQ(3), GNB1(1), GNB3(3), GNB4(3), GNB5(1), GNG3(2), GNG7(1), GRK4(5), GRK5(3), GRK6(3), GSTO1(1), GUCA2B(2), GUCY1A3(12), IGFBP1(2), IGFBP2(1), IGFBP3(2), IGFBP4(2), IL6(1), ITPR1(11), ITPR2(12), ITPR3(11), MYL2(1), MYLK2(2), NFKB1(3), NOS1(5), NOS3(2), OXTR(2), PDE4B(2), PDE4D(3), PKIA(1), PKIB(1), PLCB3(3), PLCD1(6), PLCG1(4), PLCG2(9), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(4), PRKCH(2), PRKCQ(4), PRKD1(10), RAMP1(1), RAMP3(3), RGS1(1), RGS10(1), RGS14(2), RGS16(2), RGS17(1), RGS18(2), RGS2(1), RGS20(3), RGS3(8), RGS4(2), RGS6(3), RGS7(4), RGS9(4), RYR1(19), RYR2(48), RYR3(31), SLC8A1(11), SP1(2), TNXB(14), USP5(3), YWHAB(2), YWHAQ(1)	36708703	440	97	436	165	188	93	12	107	40	0	0.0750	0.247
188	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(7), ARHGAP5(6), ARHGDIB(3), CASP1(2), CASP10(2), CASP3(1), CASP8(11), CASP9(2), GZMB(1)	2854972	35	26	33	9	5	7	1	12	10	0	0.0805	0.264
189	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(3), ALDOA(1), ALDOB(5), ALDOC(1), TPI1(1)	847422	11	11	11	1	2	0	0	9	0	0	0.0827	0.269
190	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(3), ADCY1(4), CCNB1(2), CDC25C(3), GNAI1(3), GNAS(6), GNB1(1), MAPK1(2), MAPK3(2), MYT1(8), PIN1(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), RPS6KA1(1), SRC(3)	4486219	46	35	46	17	18	12	2	12	2	0	0.0831	0.269
191	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(4), CD3D(1), CD3G(2), CD4(2), CREBBP(21), CSK(1), GNAS(6), GNB1(1), HLA-DRA(4), HLA-DRB1(1), LCK(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PTPRC(9), ZAP70(4)	5055453	65	34	65	20	21	20	5	8	9	2	0.0852	0.273
192	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(4), CD3D(1), CD3G(2), CD4(2), CREBBP(21), CSK(1), GNAS(6), GNB1(1), HLA-DRA(4), HLA-DRB1(1), LCK(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PTPRC(9), ZAP70(4)	5055453	65	34	65	20	21	20	5	8	9	2	0.0852	0.273
193	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(3), ACO2(2), FH(1), IDH1(3), IDH2(7), MDH1(1), MDH2(1), SDHB(2), SUCLA2(3)	2021902	23	20	23	4	9	4	0	7	3	0	0.0914	0.292
194	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(2), CREBBP(21), DFFA(2), DFFB(2), GZMA(2), GZMB(1), HMGB2(1)	2302357	32	22	32	8	7	13	1	5	6	0	0.0930	0.295
195	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(6), AGT(4), AGTR1(3), AGTR2(4), ANPEP(5), CPA3(2), CTSA(3), CTSG(2), ENPEP(7), LNPEP(6), MAS1(1), MME(6), NLN(1), REN(3)	4795277	55	35	55	10	14	17	2	14	8	0	0.0945	0.299
196	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(5), CCR3(3), CCR5(1), CCR7(1), CD28(1), CD4(2), CXCR4(3), IFNG(1), IFNGR1(2), IFNGR2(1), IL12B(2), IL12RB1(2), IL12RB2(5), IL18R1(8), IL2(3), IL4(3), IL4R(1), TGFB1(1), TGFB2(5)	4332673	50	29	51	27	13	17	0	15	5	0	0.0972	0.306
197	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(4), CCNE1(3), CDK2(2), CUL1(7), RB1(4), SKP2(1), TFDP1(4)	2015990	25	19	25	4	6	3	1	11	3	1	0.113	0.352
198	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD3G(2), CD4(2), FYN(4), HLA-DRA(4), HLA-DRB1(1), LCK(2), PTPRC(9), ZAP70(4)	2046111	29	19	29	8	7	10	2	3	5	2	0.123	0.382
199	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5R1(1), EGR1(2), KLK2(3), MAP2K1(3), MAPK1(2), MAPK3(2), NGFR(2), RAF1(4)	1778425	19	16	16	5	6	3	2	5	3	0	0.124	0.382
200	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	ABP1(1), ACAT1(1), ACAT2(2), ACMSD(3), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), AOC2(4), AOC3(4), AOX1(5), CAT(2), CYP19A1(5), CYP1A1(6), CYP1A2(2), CYP2A13(6), CYP2A6(3), CYP2A7(5), CYP2C19(4), CYP2C8(2), CYP2C9(4), CYP2E1(5), CYP2F1(3), CYP2J2(3), CYP3A4(1), CYP3A5(3), CYP3A7(4), CYP4B1(8), CYP4F8(4), CYP51A1(3), DDC(1), ECHS1(2), EHHADH(2), GCDH(3), HAAO(2), HADHA(2), KMO(3), KYNU(6), MAOA(2), SDS(2), TDO2(2), TPH1(1), WARS(1), WARS2(2)	12169758	152	54	152	38	57	36	2	45	11	1	0.127	0.391
201	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25A(2), CDC25B(5), CDC25C(3), CSK(1), GRB2(2), PRKCA(2), PTPRA(2), SRC(3)	2105138	22	19	22	8	5	6	1	10	0	0	0.138	0.422
202	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(10), C5(9), C6(10), C7(2), ICAM1(2), IL1A(1), IL6(1), ITGA4(3), ITGAL(5), ITGB1(6), ITGB2(4), SELP(4), SELPLG(1), VCAM1(7)	5463624	65	33	64	20	23	17	0	18	6	1	0.144	0.439
203	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(5), G6PD(2), GCLC(4), GCLM(1), GGT1(3), GPX1(1), GPX2(2), GPX3(1), GPX5(4), GSS(4), GSTA1(1), GSTA3(3), GSTM2(2), GSTM3(2), GSTM4(2), GSTM5(1), GSTZ1(2), IDH1(3), IDH2(7), MGST1(2), MGST3(1), PGD(1)	3966757	54	29	52	7	11	16	2	19	6	0	0.145	0.440
204	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL12B(2), IL13(1), IL15(1), IL16(5), IL1A(1), IL2(3), IL3(3), IL4(3), IL6(1), IL9(1)	2172653	25	19	24	15	11	3	1	9	1	0	0.154	0.466
205	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(2), FH(1), IDH2(7), MDH1(1), OGDH(4), SDHA(5), SUCLA2(3)	2086712	23	20	23	6	11	4	0	4	4	0	0.157	0.471
206	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CDS1(1), CDS2(4), DGKA(1), DGKB(7), DGKD(9), DGKE(1), DGKG(3), DGKH(5), DGKI(6), DGKZ(2), IMPA1(2), IMPA2(2), INPP1(2), INPP4A(2), INPP4B(5), INPP5A(2), INPP5B(1), INPP5D(2), INPPL1(3), ITGB1BP3(1), ITPK1(2), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), OCRL(5), PI4KA(11), PI4KB(2), PIK3C2A(2), PIK3C2B(3), PIK3C2G(7), PIK3C3(5), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(1), PIP5K1C(3), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PLCD1(6), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(4), PLCG2(9), PLCZ1(3), PRKCA(2), PRKCG(8), PTEN(6), PTPMT1(2), SYNJ1(8), SYNJ2(5)	27051791	293	79	274	78	114	71	9	67	31	1	0.162	0.484
207	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ACTR3(2), ARHGAP4(1), ARHGAP5(6), ARHGAP6(1), ARHGEF1(4), ARHGEF11(9), ARHGEF5(7), ARPC1A(5), ARPC1B(2), ARPC2(1), CFL1(1), DIAPH1(1), LIMK1(4), MYL2(1), MYLK(11), OPHN1(4), PIP5K1A(3), PIP5K1B(1), PPP1R12B(5), ROCK1(8), SRC(3), TLN1(5), VCL(1)	10247563	87	49	85	29	32	15	4	21	15	0	0.167	0.496
208	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(7), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIK(1), BIRC2(2), BIRC3(2), CASP3(1), CASP6(1), CASP7(1), CASP8(11), CASP9(2), DFFA(2), DFFB(2), DIABLO(1)	3103630	38	27	37	8	9	10	1	12	6	0	0.174	0.515
209	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CDK2(2), CDKN1B(1), CKS1B(1), CUL1(7), RB1(4), SKP2(1), TFDP1(4)	1979499	23	18	23	3	4	2	1	11	4	1	0.179	0.527
210	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(6), ARHGEF1(4), GNA12(2), GNA13(2), GNAQ(3), GNB1(1), MYL2(1), MYLK(11), PLCB1(8), PPP1R12B(5), PRKCA(2), ROCK1(8)	4650654	53	30	51	14	13	10	3	15	12	0	0.180	0.528
211	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(5), ADC(1), ALDH4A1(2), ALDH5A1(4), CAD(10), CPS1(8), EPRS(10), GAD1(7), GAD2(4), GCLC(4), GCLM(1), GFPT1(3), GFPT2(3), GLS2(2), GLUD1(2), GLUD2(4), GLUL(3), GMPS(5), GOT1(5), GOT2(1), GPT2(2), GSR(1), GSS(4), NADSYN1(2), NAGK(2), PPAT(3), QARS(7)	8826901	105	45	105	24	39	28	2	29	7	0	0.181	0.528
212	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(4), GNAS(6), GNB1(1), PPP2CA(1), PRKAA1(2), PRKAA2(6), PRKAB1(1), PRKAB2(1), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAG2(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2)	3353145	32	26	32	16	12	6	2	9	3	0	0.184	0.532
213	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(2), EGF(3), EGFR(10), GRB2(2), MAP2K1(3), MAPK1(2), MAPK3(2), PTPRB(4), RAF1(4), RASA1(5), SHC1(3), SOS1(5), SPRY1(2), SPRY4(2), SRC(3)	5246046	52	31	50	19	17	15	4	12	4	0	0.184	0.532
214	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	CRKL(2), GNAQ(3), GRB2(2), MAP2K1(3), MAP2K3(2), MAP2K4(9), MAP3K1(6), MAPK1(2), MAPK14(3), MAPK3(2), MAPK8(2), PAK1(4), PLCG1(4), PRKCA(2), PTK2B(1), RAF1(4), SHC1(3), SOS1(5), SRC(3), SYT1(1)	6404069	63	35	60	20	17	16	5	17	8	0	0.185	0.532
215	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(3), P2RY1(3), P2RY2(2)	1250559	17	14	17	4	7	4	1	4	1	0	0.188	0.537
216	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(7), CR2(9), HLA-DRA(4), HLA-DRB1(1), ICAM1(2), ITGAL(5), ITGB2(4), PTPRC(9)	3166501	41	24	41	10	11	14	0	9	5	2	0.191	0.544
217	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(2), CSF1(1), HLA-DRA(4), HLA-DRB1(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL11(1), IL12B(2), IL13(1), IL15(1), IL1A(1), IL2(3), IL3(3), IL4(3), IL6(1), IL7(1), PDGFA(1), TGFB1(1), TGFB2(5)	2979184	36	21	35	17	15	5	0	11	3	2	0.196	0.556
218	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(4), AGTR1(3), EGFR(10), GNAQ(3), GRB2(2), MAP2K1(3), MAP2K4(9), MAP3K1(6), MAPK1(2), MAPK3(2), MAPK8(2), MEF2A(3), MEF2C(7), MEF2D(1), PAK1(4), PRKCA(2), PTK2(5), PTK2B(1), RAF1(4), SHC1(3), SOS1(5), SRC(3), SYT1(1)	7481198	85	39	82	26	27	23	4	21	10	0	0.215	0.604
219	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(4), AGTR2(4), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), F2(2), FYN(4), GNA11(1), GNAI1(3), GNB1(1), GRB2(2), JAK2(6), MAP2K1(3), MAPK1(2), MAPK14(3), MAPK3(2), MAPK8(2), MAPT(4), MYLK(11), PLCG1(4), PRKCA(2), PTK2B(1), RAF1(4), SHC1(3), SOS1(5), STAT1(6), STAT3(2), SYT1(1)	9462747	89	42	87	27	25	24	9	21	9	1	0.216	0.604
220	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(2), ADH1B(2), ADH1C(3), ADH4(1), ADH6(5), ADH7(2), ADHFE1(6), AKR1C4(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), BAAT(2), CEL(1), CYP27A1(3), CYP7A1(4), HADHB(1), SOAT2(1), SRD5A1(1), SRD5A2(1)	5194000	65	33	65	11	20	18	1	23	3	0	0.216	0.604
221	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(6), GBA3(3), LPO(2), MPO(3), PRDX6(2), TPO(8)	1812945	24	20	23	10	13	3	0	4	4	0	0.234	0.653
222	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(4), CREBBP(21), EP300(13), HDAC3(2), IKBKB(2), NFKB1(3), RELA(2), RIPK1(2), TNFRSF1A(1), TRADD(1), TRAF6(4)	5112898	55	32	55	17	20	19	2	7	7	0	0.235	0.653
223	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(2), B3GNT2(1), B3GNT7(4), B4GALT1(5), B4GALT2(3), B4GALT3(6), CHST1(6), CHST2(1), CHST4(5), FUT8(1), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2)	2751228	42	27	42	12	25	7	0	7	3	0	0.238	0.657
224	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(4), ACO1(3), ACO2(2), ACSS1(3), ACSS2(5), FH(1), IDH1(3), IDH2(7), MDH1(1), MDH2(1), SUCLA2(3)	3020520	33	23	33	6	15	7	0	8	3	0	0.239	0.657
225	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(6), GBA3(3), LPO(2), MPO(3), PRDX6(2), TPO(8), TYR(2)	2094617	26	21	25	11	13	3	0	6	4	0	0.240	0.657
226	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(3), BHMT(3), CBS(2), CTH(1), DNMT1(12), DNMT3A(7), DNMT3B(3), MARS(3), MAT1A(5), MAT2B(2), MTR(6)	3945731	47	29	44	10	23	8	1	8	7	0	0.247	0.673
227	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREB1(1), CREBBP(21), EP300(13), NCOA3(6), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), RXRA(1)	4603883	51	31	51	12	15	20	2	8	6	0	0.250	0.675
228	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(2), GRIA2(10), PPP1R1B(1)	814862	13	11	13	3	6	3	0	3	1	0	0.252	0.675
229	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(6), GRB2(2), LYN(4), MAP2K1(3), MAP3K1(6), MAPK1(2), MAPK3(2), MAPK8IP3(1), PAPPA(13), RPS6KA1(1), RPS6KA3(3), SHC1(3), SOS1(5), VAV1(11), VAV2(2), VAV3(10)	7169485	74	38	72	20	30	13	5	20	6	0	0.253	0.675
230	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QB(1), C1R(2), C1S(3), C3(10), C5(9), C6(10), C7(2), C8A(3), C9(4)	3887230	44	23	44	15	14	9	0	13	7	1	0.253	0.675
231	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), DAG1(4), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), NFAT5(5), PDE6A(6), PDE6B(5), PDE6C(8), PDE6D(1), SLC6A13(5), TF(7)	7648862	86	38	86	26	35	13	7	23	8	0	0.254	0.675
232	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(3), ABAT(5), ACAT1(1), ACAT2(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH5A1(4), ALDH9A1(1), ECHS1(2), EHHADH(2), GAD1(7), GAD2(4), HADHA(2), L2HGDH(3), OXCT1(3), PDHA1(4), PDHA2(6), PDHB(2), SDHB(2), SDS(2)	5884604	82	36	82	14	31	20	0	25	6	0	0.255	0.675
233	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(4), FARSA(1), FARSB(7), GOT1(5), GOT2(1), PAH(4), TAT(3), YARS(2), YARS2(3)	1991988	30	18	30	5	10	6	1	8	5	0	0.255	0.675
234	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(2), UGDH(3), UXS1(6)	852892	12	10	12	4	5	3	0	3	1	0	0.260	0.684
235	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(6), AGT(4), AGTR2(4), EDN1(1), EDNRA(4), EDNRB(7), EGF(3), EGFR(10), NFKB1(3), PLCG1(4), PRKCA(2), RELA(2)	4651612	50	31	50	16	22	9	0	14	5	0	0.262	0.687
236	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(4), MDH1(1), ME1(7), PC(3), PDHA1(4), SLC25A11(1)	2053472	20	19	20	5	8	5	0	3	4	0	0.264	0.689
237	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(3), ALG6(3), CCKBR(3), CCR3(3), CCR5(1), CELSR1(8), CELSR2(8), CELSR3(5), CHRM2(8), CHRM3(4), EDNRA(4), EMR2(2), EMR3(7), FSHR(6), GHRHR(2), GNRHR(4), GPR116(7), GPR132(1), GPR133(7), GPR143(2), GPR17(1), GPR55(1), GPR56(1), GPR61(4), GPR77(1), GPR84(3), GPR88(1), GRM1(9), GRPR(3), HRH4(2), LPHN2(10), LPHN3(10), NTSR1(1), OR2M4(8), OR8G2(1), P2RY13(2), PTGFR(6), SSTR2(2), TAAR5(5), TSHR(6), VN1R1(4)	14477856	169	60	166	60	65	36	4	47	17	0	0.265	0.689
238	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(4), CREBBP(21), DUSP1(2), EP300(13), IKBKB(2), MAP2K3(2), MAP2K6(2), MAP3K14(2), MAP3K7(2), MAPK14(3), MYD88(1), NFKB1(3), NR3C1(3), RELA(2), TGFBR1(6), TGFBR2(7), TLR2(2)	6669795	77	36	76	27	26	20	4	18	9	0	0.268	0.692
239	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(7), BAD(1), BAX(1), BCL2(1), BCL2L1(1), BOK(1), CASP1(2), CASP10(2), CASP2(4), CASP3(1), CASP4(1), CASP6(1), CASP7(1), CASP8(11), CASP9(2), CD40LG(6), CRADD(1), DFFA(2), DFFB(2), FASLG(1), IKBKE(3), NFKB1(3), NGFR(2), NR3C1(3), NTRK1(6), PTPN13(8), RIPK1(2), SFRS2IP(3), TFG(6), TNFRSF1A(1), TRADD(1), TRAF1(1), TRAF2(1), TRAF3(4), TRAF6(4)	9681319	97	46	95	40	28	19	5	29	15	1	0.269	0.692
240	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(2), B3GNT1(2), B3GNT2(1), B3GNT4(1), B3GNT5(1), B4GALT1(5), B4GALT2(3), B4GALT3(6), FUT1(1), FUT2(1), FUT3(3), FUT6(1), FUT9(4), GCNT2(9), ST3GAL6(4), ST8SIA1(3)	3496006	47	27	47	10	20	8	2	13	4	0	0.270	0.693
241	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(4), CCNB1(2), CCND2(1), CCND3(1), CCNE1(3), CCNH(2), CDC25A(2), CDK2(2), CDK4(2), CDK6(1), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), RB1(4), RBL1(3), TFDP1(4)	3577268	36	26	36	9	11	7	1	13	3	1	0.278	0.710
242	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(1), ADH1B(2), ADH1C(3), ADH4(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A3(4), ALDH3A1(2), ALDH3B1(2), ALDH3B2(1), AOC2(4), AOC3(4), AOX1(5), DBH(4), DCT(9), DDC(1), FAH(1), GOT1(5), GOT2(1), GSTZ1(2), HGD(1), HPD(3), MAOA(2), TAT(3), TPO(8), TYR(2)	6890114	84	40	83	35	35	19	2	25	3	0	0.279	0.710
243	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(5), CARS2(1), CDO1(1), CTH(1), GOT1(5), GOT2(1), LDHA(1), LDHAL6A(2), LDHAL6B(1), LDHB(1), LDHC(2), SDS(2), SULT1B1(3), SULT1C2(1), SULT1C4(3), SULT4A1(1)	2869834	31	20	29	3	13	7	1	7	3	0	0.283	0.719
244	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(7), BAD(1), BAK1(1), BAX(1), BCL10(3), BCL2(1), BCL2L1(1), BCL2L11(2), BID(1), CASP8AP2(12), CASP9(2), CES1(4)	2327323	36	21	36	8	11	5	0	13	7	0	0.285	0.720
245	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(7), GRB2(2), IL3(3), JAK2(6), MAP2K1(3), MAPK3(2), PTPN6(4), RAF1(4), SHC1(3), SOS1(5), STAT5B(2)	3740633	41	24	38	9	17	7	4	8	4	1	0.288	0.723
246	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	81	ANPEP(5), CD14(1), CD19(3), CD1A(2), CD1D(1), CD1E(5), CD2(3), CD22(8), CD33(1), CD34(1), CD36(1), CD37(2), CD38(1), CD3D(1), CD3G(2), CD4(2), CD44(3), CD5(2), CD55(3), CD7(1), CD8B(2), CD9(1), CR1(7), CR2(9), CSF1(1), CSF1R(3), CSF3R(9), DNTT(5), FCER2(1), FCGR1A(1), FLT3(3), FLT3LG(1), GP1BA(1), GP5(5), GYPA(1), HLA-DRA(4), HLA-DRB1(1), IL11(1), IL11RA(1), IL1A(1), IL1R1(3), IL1R2(3), IL2RA(2), IL3(3), IL4(3), IL4R(1), IL5RA(4), IL6(1), IL6R(2), IL7(1), IL7R(2), ITGA1(3), ITGA2(5), ITGA2B(2), ITGA3(4), ITGA4(3), ITGA5(7), ITGA6(3), ITGAM(5), ITGB3(7), KIT(6), KITLG(2), MME(6), MS4A1(4), TFRC(2), THPO(1), TPO(8)	17773655	199	61	196	59	78	40	3	59	17	2	0.289	0.723
247	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(21), EP300(13), LPL(6), NCOA1(6), NCOA2(4), PPARG(1), RXRA(1)	3981028	52	26	52	18	13	20	3	9	7	0	0.290	0.723
248	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(4), GNAS(6), GNB1(1), PRKAR1A(1)	1425557	12	12	12	8	5	3	1	3	0	0	0.291	0.723
249	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(3), JAK2(6), JAK3(6), PIAS1(3), PIAS3(4), PTPRU(6), REG1A(3), SOAT1(1)	3010939	32	22	30	11	15	7	1	3	5	1	0.294	0.727
250	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(2), AASS(7), KARS(3)	1089983	13	10	13	2	4	2	0	5	2	0	0.295	0.727
251	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(5), ALDOC(1), FBP2(2), GOT1(5), GOT2(1), GPT2(2), MDH1(1), MDH2(1), ME1(7), ME2(3), ME3(4), PGK1(3), PKM2(2), RPE(2), RPIA(3), TKT(3), TPI1(1)	3973236	47	29	47	10	14	8	1	19	5	0	0.298	0.729
252	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(4), ABAT(5), ADSL(7), ADSS(1), AGXT2(5), ASNS(1), ASPA(3), CAD(10), CRAT(3), DARS(3), DDO(2), GAD1(7), GAD2(4), GOT1(5), GOT2(1), GPT2(2), NARS(2), PC(3)	5858433	68	38	68	18	31	16	0	17	4	0	0.299	0.729
253	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(1), CALCR(3), CALCRL(5), CD97(3), CRHR1(1), CRHR2(4), ELTD1(5), EMR1(5), EMR2(2), GHRHR(2), GLP1R(2), GLP2R(3), GPR64(5), LPHN1(3), LPHN2(10), LPHN3(10), SCTR(3), VIPR1(3), VIPR2(3)	5936337	73	35	71	25	25	14	1	24	9	0	0.300	0.729
254	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(6), CYP2A6(3), CYP2A7(5), XDH(7)	1773025	23	15	23	9	6	7	1	6	3	0	0.305	0.729
255	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(5), G6PD(2), GCLC(4), GCLM(1), GGT1(3), GPX1(1), GPX2(2), GPX3(1), GPX5(4), GPX6(2), GSR(1), GSS(4), GSTA1(1), GSTA3(3), GSTA5(1), GSTM2(2), GSTM3(2), GSTM4(2), GSTM5(1), GSTZ1(2), IDH1(3), IDH2(7), MGST1(2), MGST3(1)	4766499	57	30	55	9	11	16	2	21	7	0	0.307	0.729
256	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGT(4), AGTR1(3), AGTR2(4), BDKRB2(2), KNG1(3), NOS3(2), REN(3)	2194883	23	19	23	5	8	5	0	6	4	0	0.307	0.729
257	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), CSF1(1), IL11(1), IL2(3), IL3(3), IL4(3), IL6(1), IL7(1), IL9(1)	1411652	16	12	15	4	7	3	0	5	1	0	0.307	0.729
258	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(2), EPX(6), LPO(2), MPO(3), MTHFR(6), PRDX6(2), SHMT1(1), SHMT2(2), TPO(8)	2537296	33	23	32	10	18	5	0	7	3	0	0.308	0.729
259	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(2)	166939	2	2	2	0	1	0	0	0	1	0	0.308	0.729
260	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(12), ESR2(2), PDE1A(3), PDE1B(2), PLCB1(8), PLCB2(3), PRL(2), TRH(1)	2504248	33	20	33	8	13	9	0	7	4	0	0.309	0.729
261	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(4), PLCD1(6), PRKCA(2), TGM2(4)	1129699	16	11	16	4	6	2	1	6	1	0	0.309	0.729
262	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), GNAI1(3), GNB1(1), ITGA1(3), ITGB1(6), MAP2K1(3), MAPK1(2), MAPK3(2), PLA2G4A(5), PLCB1(8), PRKCA(2), PTGS1(4), PTK2(5), RAF1(4), SRC(3), TBXAS1(5)	5577911	58	32	57	17	23	13	2	17	3	0	0.317	0.746
263	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(2), B4GALT1(5), B4GALT2(3), B4GALT3(6), B4GALT5(2), FUT8(1), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2)	1810012	27	19	27	4	14	6	0	5	2	0	0.322	0.751
264	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(14), CPT1A(5), LEP(1), LEPR(5), PRKAA1(2), PRKAA2(6), PRKAB1(1), PRKAB2(1), PRKAG1(1), PRKAG2(2)	3310353	38	23	38	13	13	8	0	12	5	0	0.322	0.751
265	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(3), TPI1(1)	351993	4	4	4	0	0	0	0	4	0	0	0.323	0.751
266	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG5(3), ATG7(1), BECN1(2), IFNA1(1), IFNA10(1), IFNA13(2), IFNA16(4), IFNA2(3), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNG(1), PIK3C3(5), PIK3R4(12), PRKAA1(2), PRKAA2(6), ULK2(4), ULK3(3)	4664018	59	28	59	14	11	17	2	26	3	0	0.326	0.752
267	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(2), F3(1), F5(14), F7(2), FGA(11), FGB(1), FGG(4), PROC(1), PROS1(3), SERPINC1(3)	3699195	43	24	43	10	9	11	1	18	4	0	0.326	0.752
268	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD9(3), ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), DHRS1(1), DHRS2(2), DHRS3(2), ESCO1(7), ESCO2(3), MYST3(13), MYST4(5), PNPLA3(4), SH3GLB1(3)	5432175	63	31	63	22	22	16	3	18	4	0	0.329	0.755
269	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(5), ALDOC(1), FBP2(2), GOT1(5), GOT2(1), GPT2(2), MDH1(1), MDH2(1), ME1(7), ME3(4), PGK1(3), PGK2(6), PKM2(2), RPE(2), RPIA(3), TKT(3), TKTL1(4), TKTL2(5), TPI1(1)	4448432	59	32	59	14	19	11	0	23	6	0	0.330	0.756
270	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(4), CCNA2(3), CCNE1(3), CCNE2(1), CDK2(2), CDK4(2), CDKN1B(1), CDKN2A(1), E2F2(1), E2F4(1)	1943874	19	16	19	4	6	3	0	9	1	0	0.333	0.757
271	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(4), CFTR(8), GNAS(6), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), SLC9A3R1(3)	2834468	28	23	28	10	10	4	1	10	3	0	0.333	0.757
272	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(3), ACTN1(3), ACTN2(7), ACTN3(2), BCR(6), CAPN1(2), CAPNS1(1), CAPNS2(1), CRKL(2), CSK(1), FYN(4), GRB2(2), ITGA1(3), ITGB1(6), MAP2K1(3), MAPK1(2), MAPK3(2), MAPK8(2), PPP1R12B(5), PTK2(5), RAF1(4), RAP1A(1), ROCK1(8), SHC1(3), SOS1(5), SRC(3), TLN1(5), VCL(1)	10350397	92	48	89	29	38	22	3	22	7	0	0.339	0.767
273	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(2), BIRC3(2), CASP8(11), RIPK1(2), TNFRSF1A(1), TRADD(1), TRAF2(1)	1919325	20	17	19	4	4	5	2	5	4	0	0.340	0.767
274	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(5), NR1I3(2), PTGS1(4), PTGS2(2)	1190438	15	12	15	2	7	4	0	4	0	0	0.350	0.784
275	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(3), GTF2H1(2), GTF2H3(4), GTF2H4(1), GTF2IRD1(8), TAF1(7), TAF1L(16), TAF2(6), TAF4(4), TAF4B(4), TAF5(3), TAF5L(1), TAF6(2), TAF6L(2), TAF7(1), TAF7L(3), TAF9B(1), TBPL1(1), TBPL2(1)	8143764	78	41	78	21	30	17	1	24	6	0	0.350	0.784
276	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(1), IL6R(2), JAK1(3), JAK2(6), JAK3(6), PIAS3(4), PTPRU(6), REG1A(3), SRC(3), STAT3(2)	3429621	36	24	34	16	17	10	1	4	3	1	0.352	0.787
277	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(3), CANX(2), CD4(2), CD74(1), CD8B(2), CIITA(6), CREB1(1), CTSB(2), CTSL1(3), CTSS(2), HLA-A(1), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DRA(4), HLA-DRB1(1), HLA-E(1), HLA-F(1), HLA-G(1), HSP90AA1(2), HSP90AB1(1), IFI30(1), IFNA1(1), IFNA10(1), IFNA13(2), IFNA16(4), IFNA2(3), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), KIR2DL1(2), KIR2DL3(1), KIR2DL4(2), KIR3DL1(3), KIR3DL2(3), KIR3DL3(4), KLRC3(2), KLRC4(1), KLRD1(1), LGMN(1), NFYA(1), NFYB(1), NFYC(3), PDIA3(1), RFX5(1), RFXAP(1), TAP1(3), TAP2(4), TAPBP(3)	10267263	107	41	104	30	21	27	5	32	17	5	0.356	0.791
278	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(2), CSF1R(3), EGF(3), EGFR(10), GRB2(2), MET(4), PDGFRA(13), PRKCA(2), SH3GLB1(3), SH3GLB2(2), SH3KBP1(4), SRC(3)	4379823	51	25	51	25	14	12	3	17	4	1	0.359	0.795
279	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(4), MAP3K14(2), MAPK14(3), MAPK8(2), NFKB1(3), RELA(2), TNFRSF13B(4), TNFRSF17(2), TNFSF13(2), TRAF2(1), TRAF3(4), TRAF5(4), TRAF6(4)	3197661	37	25	36	11	17	6	0	8	6	0	0.366	0.809
280	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(1), IL12B(2), IL2(3)	665213	8	6	8	5	0	3	0	5	0	0	0.370	0.814
281	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(5), ASAH1(3), BRAF(21), DAG1(4), DRD2(3), EGFR(10), EPHB2(7), GRB2(2), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), KCNJ3(6), KCNJ5(3), KCNJ9(2), MAPK1(2), PIK3CB(2), PITX2(2), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), RAF1(4), RGS20(3), SHC1(3), SOS1(5), SOS2(9), SRC(3), STAT3(2), TERF2IP(1)	12794595	165	54	144	48	58	30	7	59	11	0	0.372	0.815
282	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(6), ADCY4(9), ADCY6(1), ADCY8(11), CACNA1A(8), CACNA1B(7), GNAS(6), GNAT3(1), GNB1(1), GNB3(3), GNG3(2), GRM4(7), ITPR3(11), KCNB1(2), PDE1A(3), PLCB2(3), PRKACB(1), PRKACG(2), PRKX(2), SCNN1A(3), SCNN1B(3), SCNN1G(2), TAS1R1(6), TAS1R2(5), TAS2R1(1), TAS2R10(3), TAS2R13(3), TAS2R16(1), TAS2R3(1), TAS2R38(2), TAS2R39(2), TAS2R4(1), TAS2R41(1), TAS2R46(1), TAS2R5(1), TAS2R50(4), TAS2R60(1), TAS2R8(1), TAS2R9(1)	11915572	129	53	129	46	52	24	3	40	10	0	0.375	0.816
283	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(6), PARK2(4), SNCA(1), SNCAIP(1), UBE2F(1), UBE2G1(2), UBE2L3(2)	1454834	17	13	17	7	5	5	0	6	1	0	0.379	0.816
284	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(17), ABCA10(7), ABCA12(22), ABCA13(23), ABCA3(5), ABCA4(10), ABCA5(15), ABCA6(12), ABCA7(5), ABCA8(10), ABCA9(12), ABCB1(6), ABCB10(3), ABCB11(8), ABCB4(8), ABCB5(10), ABCB6(3), ABCB7(3), ABCB8(4), ABCB9(2), ABCC1(8), ABCC10(7), ABCC11(9), ABCC12(7), ABCC2(11), ABCC3(5), ABCC4(9), ABCC5(5), ABCC6(5), ABCC8(7), ABCC9(7), ABCD1(3), ABCD2(8), ABCD3(3), ABCD4(5), ABCG1(5), ABCG2(5), ABCG4(3), ABCG5(1), ABCG8(4), CFTR(8), TAP1(3), TAP2(4)	26106513	317	72	315	96	100	74	7	94	40	2	0.380	0.816
285	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	CHAT(6), DBH(4), DDC(1), GAD1(7), GAD2(4), HDC(3), MAOA(2), PAH(4), SLC18A3(6), TPH1(1)	3220226	38	26	38	18	16	10	1	10	1	0	0.381	0.816
286	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(6), APOBEC1(2), APOBEC2(1), APOBEC3A(1), APOBEC3C(3), APOBEC3F(1), APOBEC3G(2), APOBEC4(2)	1633065	18	14	18	3	7	4	0	5	2	0	0.381	0.816
287	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), GRB2(2), HBXIP(2), PTK2B(1), SHC1(3), SOS1(5), SRC(3)	1995497	17	15	16	6	2	4	2	6	3	0	0.382	0.816
288	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(3), ACTR2(1), ACTR3(2), ARPC1A(5), ARPC1B(2), ARPC2(1), NCKAP1(8), NTRK1(6), WASF1(1), WASF2(2), WASF3(2), WASL(5)	3437407	38	24	38	9	12	9	2	11	4	0	0.383	0.816
289	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(3), BHMT(3), CBS(2), CTH(1), DNMT1(12), DNMT3A(7), DNMT3B(3), MARS(3), MAT1A(5), MAT2B(2), MTFMT(1), MTR(6), TAT(3)	4665290	51	31	48	13	24	10	1	8	8	0	0.383	0.816
290	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(3), EPHA4(4), EPHB1(6), FYN(4), ITGA1(3), ITGB1(6), L1CAM(2), LYN(4), RAP1B(2), SELP(4)	3376427	38	23	38	8	14	12	0	9	3	0	0.390	0.829
291	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(3), GGT1(3), SHMT1(1), SHMT2(2)	820800	9	9	7	4	2	4	0	0	3	0	0.392	0.829
292	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(5), CTH(1), GOT1(5), GOT2(1), LDHA(1), LDHB(1), LDHC(2)	1549666	16	13	16	2	7	4	0	3	2	0	0.393	0.829
293	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(5), EIF2B5(5), EIF2S2(1), EIF2S3(1), EIF5(3), GSK3B(7)	2546207	23	17	23	3	6	7	2	3	5	0	0.396	0.829
294	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(3), IGF1(2), IL11(1), IL1A(1), IL3(3), IL6(1), IL9(1), KITLG(2), TGFB1(1), TGFB2(5)	1903197	20	16	19	8	8	1	0	8	3	0	0.396	0.829
295	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), GSTZ1(2), HGD(1)	380018	4	3	4	3	0	1	0	2	1	0	0.406	0.848
296	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(6), DLG4(2), EPHB2(7), F2(2), F2RL2(2), MAP2K5(2), MAPK1(2), MAPK7(3), MAPK8(2), MYEF2(7), PLD1(8), PLD2(1), PLD3(5), PTK2(5), RAF1(4), RASAL1(1), SRC(3), TEC(1), VAV1(11)	6158399	74	36	72	24	36	18	1	14	5	0	0.407	0.848
297	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), ATF1(1), CREB1(1), CREB3(2), CREB5(2), DUSP1(2), DUSP10(4), IL1R1(3), MAP2K3(2), MAP2K4(9), MAP2K6(2), MAP3K10(2), MAP3K4(15), MAP3K5(5), MAP3K7(2), MAPK1(2), MAPK12(2), MAPK14(3), MAPKAPK2(3), MAPKAPK5(1), MKNK1(1), MKNK2(2), MYEF2(7), NFKB1(3), NR2C2(4), SRF(3), TRAF6(4)	7659969	89	40	87	22	27	22	3	24	13	0	0.409	0.849
298	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(7), ARHGDIB(3), BIRC2(2), BIRC3(2), CASP1(2), CASP10(2), CASP2(4), CASP3(1), CASP4(1), CASP6(1), CASP7(1), CASP8(11), CASP9(2), DFFA(2), DFFB(2), GZMB(1), LMNB1(2), LMNB2(1)	4368123	47	28	46	12	9	11	2	18	7	0	0.411	0.849
299	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(4), MTMR2(1), MTMR6(4), NFS1(2), PHPT1(1), THTPA(1)	1454764	14	12	14	4	4	3	1	4	2	0	0.412	0.849
300	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYB(1), NFYC(3), RB1(4), SP1(2), SP3(2)	1533323	13	11	13	3	2	4	1	5	0	1	0.415	0.851
301	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(3), ENO3(3), FARS2(4), GOT1(5), GOT2(1), PAH(4), TAT(3), YARS(2)	1909324	25	17	25	5	8	8	0	6	3	0	0.417	0.853
302	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(3), AASDHPPT(2), AASS(7), KARS(3)	1599415	16	12	16	5	5	3	0	6	2	0	0.418	0.853
303	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(3), ESR1(12), GREB1(10), HSPB2(1), MTA1(1), PDZK1(1), TUBA8(1)	2305972	30	18	30	8	10	6	0	9	5	0	0.425	0.864
304	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT1(5), GOT2(1), TAT(3), TYR(2)	1077195	12	10	12	5	5	3	0	3	1	0	0.428	0.867
305	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(3)	471201	5	5	5	2	3	1	0	0	1	0	0.429	0.867
306	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(5), GOT2(1), TAT(3)	607023	9	7	9	1	4	3	0	1	1	0	0.439	0.882
307	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(3), LIPT1(2)	344910	5	4	5	0	0	2	0	2	1	0	0.441	0.882
308	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(4), SPCS1(1)	694979	7	7	6	2	4	0	0	1	2	0	0.441	0.882
309	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(3), CASP10(2), CASP3(1), CASP6(1), CASP7(1), CASP8(11), CFLAR(2), DFFA(2), DFFB(2), FAF1(4), LMNB1(2), LMNB2(1), MAP2K4(9), MAP3K1(6), MAP3K7(2), MAPK8(2), PAK1(4), PAK2(2), PRKDC(13), PTPN13(8), RB1(4), RIPK2(3), SPTAN1(9)	8676999	94	39	92	28	19	27	3	27	15	3	0.445	0.884
310	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(4), MMP2(2), MMP9(6), RECK(3), TIMP1(1), TIMP2(2), TIMP3(2), TIMP4(2)	1689618	22	16	22	5	13	3	2	4	0	0	0.445	0.884
311	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS2(2), GLUD1(2), GLUD2(4)	960843	8	8	8	5	6	1	0	1	0	0	0.446	0.884
312	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(1), ADAM17(6), ATP6AP1(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V0D2(6), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), CASP3(1), CHUK(4), CSK(1), EGFR(10), F11R(1), GIT1(2), HBEGF(1), IGSF5(6), IKBKB(2), JAM3(3), LYN(4), MAP2K4(9), MAP3K14(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK8(2), MAPK9(3), MET(4), NFKB1(3), NFKB2(2), NOD1(3), PAK1(4), PLCG1(4), PLCG2(9), PTPN11(2), PTPRZ1(12), RELA(2), SRC(3), TCIRG1(2), TJP1(5)	15676774	158	54	155	41	58	40	4	40	16	0	0.451	0.891
313	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), MIOX(1), UGDH(3)	1916590	24	17	24	5	9	7	0	6	2	0	0.458	0.901
314	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(32), B3GALT4(1), CDR1(1), DGKI(6), IL6ST(2), MRPL19(1), PIGK(3), RPL18A(1), RPL21(1), RPL22(2), RPL24(1), RPL28(1), RPL3(2), RPL31(2), RPL32(1), RPL35(1), RPL39(1), RPL3L(1), RPL4(2), RPL6(1), RPL7(1), RPL9(3), RPLP0(2), RPS11(1), RPS13(1), RPS16(1), RPS18(1), RPS20(1), RPS23(4), RPS3(1), RPS4X(1), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KA6(5), RPS6KB1(3), RPS6KB2(1), RPS9(2), RPSA(1), SLC36A2(1), TBC1D10C(2), TSPAN9(2), UBA52(2), UBB(1)	11427799	112	48	111	28	39	24	1	30	18	0	0.462	0.906
315	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTB(2), ARHGEF2(4), ARPC5(1), ARPC5L(1), CD14(1), CDH1(4), CTNNB1(8), EZR(2), FYN(4), HCLS1(7), ITGB1(6), KRT18(2), LY96(2), NCL(2), OCLN(1), PRKCA(2), RHOA(4), ROCK1(8), ROCK2(2), TLR4(7), TLR5(3), TUBA3C(9), TUBA3D(2), TUBA3E(4), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(2), TUBB2A(1), TUBB2B(3), TUBB3(1), TUBB4(2), TUBB4Q(2), TUBB6(3), TUBB8(2), WAS(1), WASL(5), YWHAQ(1)	11374491	121	47	120	44	44	24	2	38	13	0	0.466	0.906
316	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTB(2), ARHGEF2(4), ARPC5(1), ARPC5L(1), CD14(1), CDH1(4), CTNNB1(8), EZR(2), FYN(4), HCLS1(7), ITGB1(6), KRT18(2), LY96(2), NCL(2), OCLN(1), PRKCA(2), RHOA(4), ROCK1(8), ROCK2(2), TLR4(7), TLR5(3), TUBA3C(9), TUBA3D(2), TUBA3E(4), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(2), TUBB2A(1), TUBB2B(3), TUBB3(1), TUBB4(2), TUBB4Q(2), TUBB6(3), TUBB8(2), WAS(1), WASL(5), YWHAQ(1)	11374491	121	47	120	44	44	24	2	38	13	0	0.466	0.906
317	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(5), ALDH4A1(2), ALDH5A1(4), CAD(10), CPS1(8), EPRS(10), GAD1(7), GAD2(4), GCLC(4), GCLM(1), GFPT1(3), GLS2(2), GLUD1(2), GLUL(3), GMPS(5), GOT1(5), GOT2(1), GPT2(2), GSS(4), NADSYN1(2), PPAT(3), QARS(7)	7443276	94	37	94	17	31	26	2	28	7	0	0.466	0.906
318	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(3), ACTR2(1), ACTR3(2), ARPC1A(5), ARPC1B(2), ARPC2(1), WASF1(1), WASL(5)	1805655	20	15	20	5	7	5	1	6	1	0	0.468	0.906
319	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1)	1805955	28	17	28	3	12	8	0	8	0	0	0.479	0.922
320	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1)	1805955	28	17	28	3	12	8	0	8	0	0	0.479	0.922
321	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(3), NFKB1(3), PLCB1(8), PRKCA(2), RELA(2)	1890394	18	14	18	5	6	3	0	6	3	0	0.484	0.926
322	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(2), BAD(1), BCL2(1), CABIN1(9), CAMK2B(2), CAMK4(2), CD3G(2), CDKN1A(1), CNR1(3), CREBBP(21), CSNK2A1(4), CSNK2B(2), CTLA4(1), EGR2(6), EGR3(2), EP300(13), FCER1A(2), GATA3(4), GATA4(1), GRLF1(7), GSK3A(2), GSK3B(7), ICOS(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL13(1), IL2(3), IL2RA(2), IL3(3), IL4(3), IL6(1), ITK(8), KPNA5(4), MAPK14(3), MAPK8(2), MAPK9(3), MEF2A(3), MEF2D(1), MYF5(2), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NFKB2(2), NFKBIB(1), NFKBIE(2), NUP214(4), OPRD1(1), P2RX7(2), PAK1(4), PIN1(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PTPRC(9), RELA(2), SLA(4), SP1(2), SP3(2), TGFB1(1), TRAF2(1), TRPV6(9), VAV1(11), VAV2(2), VAV3(10)	19966925	234	64	230	77	84	63	6	53	28	0	0.484	0.926
323	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(2), ACAD9(3), ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), AKR1C4(2), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), BAAT(2), CEL(1), CYP27A1(3), CYP7A1(4), HADHB(1), HSD3B7(2), LIPA(1), RDH12(2), RDH13(1), SLC27A5(3), SOAT1(1), SOAT2(1), SRD5A1(1), SRD5A2(1)	7061346	71	36	71	20	20	21	2	23	5	0	0.492	0.938
324	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(1), CHUK(4), EGF(3), EGFR(10), ETS2(2), HOXA7(1), IKBKB(2), MAP2K1(3), MAP2K3(2), MAP2K4(9), MAP2K6(2), MAP3K1(6), MAP3K14(2), MAP3K5(5), MAPK1(2), MAPK14(3), MAPK3(2), MAPK8(2), NFKB1(3), PPP2CA(1), PRKCA(2), PRKCD(3), PRKCE(4), PRKCG(8), PRKCH(2), PRKCQ(4), RAF1(4), RELA(2), RIPK1(2), SP1(2), TNFRSF1A(1), TRAF2(1)	10903164	100	48	98	30	46	25	4	21	4	0	0.495	0.941
325	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), CD36(1), FYN(4), MAPK14(3), THBS1(8)	1625380	17	14	17	7	5	6	0	4	2	0	0.501	0.950
326	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(1), AOC2(4), AOC3(4), CES1(4)	1267882	13	12	13	4	6	3	0	4	0	0	0.506	0.957
327	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3D(1), CD3G(2), ETV5(5), IFNG(1), IL12B(2), IL12RB1(2), IL12RB2(5), IL18R1(8), JAK2(6), MAP2K6(2), MAPK14(3), MAPK8(2), TYK2(1)	4079903	41	24	42	20	9	15	1	9	6	1	0.508	0.958
328	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(2), ARSD(3), ARSE(2), CARM1(2), CYP11B1(5), CYP11B2(5), CYP19A1(5), HSD11B1(1), HSD17B12(2), HSD17B2(1), HSD17B3(1), HSD17B8(1), HSD3B1(2), LCMT1(1), LCMT2(2), METTL2B(1), METTL6(5), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), SRD5A1(1), SRD5A2(1), STS(6), SULT1E1(1), SULT2A1(1), SULT2B1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2A1(8), UGT2A3(5), UGT2B10(1), UGT2B11(4), UGT2B15(2), UGT2B17(4), UGT2B28(2), UGT2B4(2), UGT2B7(4), WBSCR22(1)	10482985	110	44	109	24	35	26	3	30	16	0	0.510	0.959
329	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(3), CHRNA1(2), SNAP25(1), STX1A(2)	729912	8	8	8	4	6	1	0	1	0	0	0.515	0.963
330	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(2), SDS(2)	2761561	36	21	36	4	15	10	0	8	3	0	0.518	0.965
331	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(6), GNB1(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2)	2085116	17	16	17	6	7	1	2	6	1	0	0.521	0.965
332	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(3), B3GALNT1(3), B3GALT5(2), FUT1(1), FUT2(1), FUT9(4), GLA(4), HEXB(1), NAGA(1), ST3GAL1(1), ST3GAL2(1), ST8SIA1(3)	2387145	25	16	25	8	8	6	0	6	5	0	0.523	0.965
333	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CSF1(1), IL6(1), LDLR(4), LPL(6)	1189147	13	10	13	2	3	3	0	5	2	0	0.523	0.965
334	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), BCAT2(1), IARS(5), IARS2(6), ILVBL(2), LARS(4), LARS2(2), PDHA1(4), PDHA2(6), PDHB(2), VARS(1), VARS2(6)	4151357	40	25	40	8	18	10	0	6	6	0	0.523	0.965
335	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(5), CKM(4), FBL(3), LDHA(1), LDHB(1), LDHC(2), MAPK14(3), NCL(2)	2012341	21	16	21	10	9	4	1	6	1	0	0.525	0.966
336	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(5), LARS(4), LARS2(2), PDHA1(4), PDHA2(6), PDHB(2)	2253000	24	15	24	4	9	6	0	5	4	0	0.533	0.972
337	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(3), CASP1(2), CASP3(1), CASP7(1), CASP8(11), INSR(5), ITCH(3), MAGI1(10), MAGI2(6), RERE(3), WWP1(5), WWP2(4)	5302230	54	33	53	19	16	12	1	15	10	0	0.533	0.972
338	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSR(1), GSS(4), NFKB1(3), NOX1(1), RELA(2), XDH(7)	2280177	19	15	19	6	5	7	1	3	3	0	0.533	0.972
339	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(5), GPI(1), HK1(6), PFKL(1), PGAM1(3), PGK1(3), TPI1(1)	1983193	20	19	19	10	9	1	0	10	0	0	0.542	0.984
340	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(5), CARM1(2), CREBBP(21), EP300(13), ERCC3(6), ESR1(12), GRIP1(7), GTF2A1(2), GTF2E1(5), GTF2F1(3), HDAC1(2), HDAC2(2), HDAC3(2), HDAC4(5), HDAC5(1), HDAC6(4), MEF2C(7), NCOR2(2), NR0B1(2), NRIP1(5), PELP1(2), POLR2A(6), TBP(1)	10316344	117	46	117	24	45	34	2	21	15	0	0.544	0.984
341	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F11(4), F12(2), F13B(3), F2(2), F5(14), F7(2), F8(15), F9(6), FGA(11), FGB(1), FGG(4), LPA(9), PLAT(4), PLAU(2), PLG(7), SERPINB2(4), SERPINE1(1), VWF(10)	7871547	102	36	100	31	23	29	3	33	14	0	0.547	0.984
342	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(2), BIRC2(2), BIRC3(2), CASP3(1), CASP8(11), CFLAR(2), MAP2K4(9), MAP3K3(2), MAP3K7(2), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), NR2C2(4), RALBP1(4), RIPK1(2), TNFAIP3(2), TNFRSF1A(1), TRADD(1), TRAF2(1)	6095213	56	32	54	10	15	16	3	16	6	0	0.548	0.984
343	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(1), CNR1(3), DNMT1(12), MTNR1B(3), PTAFR(1), PTGER2(1), PTGFR(6), PTGIR(1)	2492801	28	19	25	7	11	3	1	12	1	0	0.554	0.984
344	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(2), EPX(6), LPO(2), MPO(3), PRDX6(2), SHMT1(1), SHMT2(2), TPO(8)	2574833	27	21	26	9	17	3	0	4	3	0	0.555	0.984
345	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(3), IFNB1(1), JAK1(3), PTPRU(6), REG1A(3), STAT1(6), STAT2(5), TYK2(1)	2752150	28	19	26	7	13	6	1	5	3	0	0.555	0.984
346	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(4), GRB2(2), IL6(1), IL6R(2), IL6ST(2), JAK1(3), JAK2(6), JAK3(6), MAP2K1(3), MAPK3(2), PTPN11(2), RAF1(4), SHC1(3), SOS1(5), SRF(3), STAT3(2)	5376589	50	28	47	13	16	10	4	14	5	1	0.562	0.984
347	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(4), GNAS(6), PLCE1(7), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2)	3074220	24	20	24	9	10	4	2	5	3	0	0.563	0.984
348	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(3), AKT1(2), BDKRB2(2), CHRM1(3), CHRNA1(2), FLT1(9), FLT4(4), KDR(8), NOS3(2), PDE3A(5), PDE3B(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKG1(4), PRKG2(3), RYR2(48), SLC7A1(2), SYT1(1), TNNI1(2)	8582717	109	41	109	44	39	26	4	30	10	0	0.563	0.984
349	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), IFNGR1(2), IFNGR2(1), JAK1(3), JAK2(6), STAT1(6)	1835289	19	13	18	6	7	1	2	7	1	1	0.567	0.984
350	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(4), AARS2(6), ABAT(5), ADSL(7), ADSS(1), AGXT2(5), ASNS(1), ASPA(3), ASS1(1), CAD(10), CRAT(3), DARS(3), DARS2(2), DDO(2), DLAT(2), GAD1(7), GAD2(4), GOT1(5), GOT2(1), GPT2(2), NARS(2), NARS2(3), PC(3), PDHA1(4), PDHA2(6), PDHB(2)	8525697	94	43	94	23	41	23	0	21	9	0	0.568	0.984
351	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(6), CD79A(3), GRB2(2), LYN(4), MAP2K1(3), MAP3K1(6), MAPK14(3), MAPK3(2), MAPK8(2), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKCA(2), RAF1(4), SHC1(3), SOS1(5), SYT1(1), VAV1(11)	8524594	81	38	79	23	34	15	4	17	11	0	0.568	0.984
352	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(2)	363274	2	2	2	3	0	0	0	1	1	0	0.569	0.984
353	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA2(2), ANXA3(1), ANXA4(4), ANXA5(1), ANXA6(2), CYP11A1(2), EDN1(1), EDNRA(4), EDNRB(7), HSD11B1(1), PLA2G4A(5), PRL(2), PTGER2(1), PTGFR(6), PTGIR(1), PTGIS(4), PTGS1(4), PTGS2(2), TBXAS1(5)	4589791	55	26	55	14	22	7	0	21	5	0	0.570	0.984
354	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), MAP2K1(3), MAPK1(2), MAPK3(2), NFKB1(3), PLCB1(8), PRKCA(2), RAF1(4), RELA(2)	3476261	28	20	27	9	11	6	1	7	3	0	0.571	0.984
355	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(2), RPE(2), UGDH(3), UGP2(5), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2A1(8), UGT2A3(5), UGT2B10(1), UGT2B11(4), UGT2B15(2), UGT2B17(4), UGT2B28(2), UGT2B4(2), UGT2B7(4), XYLB(2)	5482237	63	27	62	15	16	17	1	18	11	0	0.572	0.984
356	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(3), HDAC9(11), MEF2A(3), MEF2C(7), MEF2D(1)	1545529	26	13	26	12	8	7	0	11	0	0	0.573	0.984
357	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(5), ACACA(14), ACADM(3), ACADSB(5), ACAT1(1), ACAT2(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(3), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(2), LDHA(1), LDHB(1), LDHC(2), MCEE(1), MLYCD(1), MUT(3), PCCA(3), PCCB(3), SDS(2), SUCLA2(3), SUCLG1(1)	7531279	88	35	88	16	33	22	0	23	10	0	0.574	0.984
358	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX12(2), ALOX12B(2), ALOX15B(5), ALOX5(4), CYP2C19(4), CYP2C8(2), CYP2C9(4), CYP2E1(5), CYP2J2(3), CYP2U1(1), CYP4A11(2), CYP4A22(2), CYP4F2(8), CYP4F3(2), EPHX2(1), GGT1(3), GPX1(1), GPX2(2), GPX3(1), GPX5(4), GPX6(2), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PTGIS(4), PTGS1(4), PTGS2(2), TBXAS1(5)	8722474	84	42	82	29	30	15	0	34	5	0	0.574	0.984
359	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(4), CREB1(1), GNAI1(3), GNAQ(3), GNAS(6), GNB1(1), MAP2K1(3), MAPK3(2), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), RAF1(4), RPS6KA3(3), SYT1(1)	7702126	64	39	63	23	30	9	3	14	8	0	0.575	0.984
360	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(6), ABCB11(8), ABCB4(8), ABCC1(8), ABCC3(5)	3055796	35	21	35	10	5	14	0	10	6	0	0.582	0.984
361	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), GPD2(3), NDUFA1(1), SDHA(5), SDHB(2), SDHD(1), UQCRC1(2)	1443707	16	11	16	3	5	5	0	5	1	0	0.582	0.984
362	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNG(1), IFNGR1(2), JAK1(3), JAK2(6), PTPRU(6), REG1A(3), STAT1(6)	2538159	27	16	25	9	11	4	2	7	2	1	0.583	0.984
363	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(7), BIRC2(2), BIRC3(2), CASP10(2), CASP3(1), CASP7(1), CASP8(11), CASP9(2), DFFA(2), DFFB(2), GZMB(1), SCAP(1), SREBF1(1), SREBF2(2)	4134871	37	25	36	14	6	9	2	12	8	0	0.585	0.984
364	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(3), FUT1(1), FUT2(1), FUT9(4), GLA(4), HEXB(1), NAGA(1), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2), ST8SIA1(3)	2244093	22	15	22	8	5	6	0	6	5	0	0.585	0.984
365	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(5), ACACA(14), ACACB(14), ACADM(3), ACAT1(1), ACAT2(2), ACSS1(3), ACSS2(5), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(3), ALDH7A1(1), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(2), LDHA(1), LDHAL6A(2), LDHAL6B(1), LDHB(1), LDHC(2), MCEE(1), MLYCD(1), MUT(3), PCCA(3), PCCB(3), SUCLA2(3), SUCLG1(1)	9043186	98	40	98	23	37	23	0	28	10	0	0.586	0.984
366	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(2), CDC25B(5), CDK7(1), CDKN1A(1), CHEK1(1), NEK1(7), WEE1(3)	1497944	20	12	19	7	7	4	0	8	1	0	0.588	0.984
367	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(2), ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), ADK(1), ADSL(7), ADSS(1), AK5(4), AK7(5), ALLC(3), AMPD1(7), AMPD2(4), AMPD3(2), ATIC(4), DCK(1), ENPP1(4), ENPP3(3), ENTPD1(2), ENTPD3(5), ENTPD4(5), ENTPD5(1), ENTPD6(1), FHIT(1), GART(3), GMPR(1), GMPR2(2), GMPS(5), GUCY1A2(8), GUCY1A3(12), GUCY1B3(7), GUCY2C(7), GUCY2D(4), GUCY2F(7), HPRT1(2), IMPDH1(1), IMPDH2(1), ITPA(2), NME6(3), NME7(3), NPR1(6), NPR2(9), NT5C1A(1), NT5C1B(9), NT5C2(3), NT5C3(2), NT5E(2), NT5M(1), NUDT9(2), PAPSS1(1), PAPSS2(2), PDE10A(6), PDE11A(7), PDE1A(3), PDE1C(7), PDE3B(2), PDE4A(4), PDE4B(2), PDE4C(2), PDE4D(3), PDE5A(3), PDE6D(1), PDE7A(3), PDE7B(3), PDE8A(1), PDE8B(6), PDE9A(5), PFAS(1), PKM2(2), PNPT1(5), POLA1(5), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(17), POLE3(1), POLR1A(7), POLR1B(6), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(5), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR3A(7), POLR3B(6), POLR3GL(1), POLR3H(1), PPAT(3), PRIM2(6), PRPS1L1(1), PRPS2(2), RFC5(2), RRM1(1), RRM2(2), XDH(7)	36766837	392	84	389	129	127	106	11	95	53	0	0.588	0.984
368	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(1), ALDH1A3(4), ALDH3A1(2), ALDH3B1(2), ALDH3B2(1), AOC2(4), AOC3(4), DDC(1), EPX(6), GOT1(5), GOT2(1), HPD(3), LPO(2), MAOA(2), MPO(3), PRDX6(2), TAT(3), TPO(8)	4837673	54	33	53	16	29	12	0	10	3	0	0.589	0.984
369	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), GRB2(2), IL4(3), IL4R(1), IRS1(5), JAK1(3), JAK3(6), RPS6KB1(3), SHC1(3), STAT6(2)	3273899	30	21	28	10	10	7	2	6	5	0	0.590	0.984
370	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(4), ACO1(3), ACO2(2), CLYBL(5), FH(1), IDH1(3), IDH2(7), IDH3A(1), IDH3G(2), MDH1(1), MDH2(1), OGDH(4), OGDHL(8), PC(3), PCK2(3), SDHA(5), SDHB(2), SDHD(1), SUCLA2(3), SUCLG1(1)	6634216	60	36	60	19	27	14	0	14	5	0	0.594	0.990
371	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), LCMT1(1), LCMT2(2), METTL2B(1), METTL6(5), PCYT1A(4), PCYT1B(5), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), WBSCR22(1)	3059338	31	21	31	14	9	9	0	11	2	0	0.600	0.996
372	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(2), COQ6(1), COQ7(1), NDUFA12(2), NDUFA13(1)	914763	7	7	7	2	1	2	0	2	2	0	0.605	1.000
373	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1), CD3G(2)	266355	3	2	3	1	1	1	0	0	1	0	0.615	1.000
374	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5R1(1), CSNK1D(3), DRD1(1), DRD2(3), GRM1(9), PLCB1(8), PPP1R1B(1), PPP2CA(1), PPP3CA(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2)	3496532	35	25	35	13	14	7	1	8	5	0	0.623	1.000
375	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(4), CDKN1A(1), GRIN1(1), HIF1A(1), JAK2(6), NFKB1(3), RELA(2), SOD2(4)	2875583	22	18	22	5	6	6	1	6	2	1	0.625	1.000
376	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(3), ACTN1(3), ACTN2(7), ACTN3(2), CAPN1(2), CAPNS1(1), CAPNS2(1), ITGA1(3), ITGB1(6), ITGB3(7), PTK2(5), SPTAN1(9), SRC(3), TLN1(5)	6192956	57	33	57	25	28	11	0	15	2	1	0.627	1.000
377	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(7), POLR1B(6), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(5), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR3A(7), POLR3B(6), POLR3GL(1), POLR3H(1)	5246792	47	28	47	9	17	17	1	9	3	0	0.627	1.000
378	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(17), APOE(1), CETP(6), CYP7A1(4), HMGCR(2), LCAT(1), LDLR(4), LIPC(3), LPL(6), LRP1(14), SOAT1(1)	5645238	59	31	59	18	22	14	2	16	5	0	0.628	1.000
379	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), AGK(2), AGPAT1(1), AGPAT3(3), AGPAT4(6), AGPAT6(1), AKR1B1(2), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), CEL(1), DAK(3), DGAT2(3), DGKA(1), DGKB(7), DGKD(9), DGKE(1), DGKG(3), DGKH(5), DGKI(6), DGKZ(2), GK(3), GK2(3), GLA(4), GLB1(3), GPAM(2), LCT(15), LIPA(1), LIPC(3), LIPF(1), LIPG(2), LPL(6), PNLIP(5), PNLIPRP1(4), PNLIPRP2(1), PNPLA3(4), PPAP2B(1)	12987826	154	50	153	50	49	32	2	59	12	0	0.641	1.000
380	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(3), IFNAR2(1), IFNB1(1), JAK1(3), STAT1(6), STAT2(5), TYK2(1)	2374004	21	16	20	4	10	3	1	5	2	0	0.642	1.000
381	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(3), DAG1(4), GNAQ(3), ITPKB(4)	1356844	14	10	14	5	5	3	2	2	2	0	0.643	1.000
382	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(3)	1240596	10	9	10	2	2	2	1	3	2	0	0.643	1.000
383	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(3), CYSLTR2(3), GPR161(5), GPR171(3), GPR34(5), GPR39(2), GPR45(4), GPR75(1)	2160775	26	17	26	9	12	4	1	7	2	0	0.644	1.000
384	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	DHRS1(1), DHRS2(2), DHRS3(2), HSD3B7(2), PON1(5), PON2(1), PON3(2), RDH12(2), RDH13(1)	1878267	18	14	18	7	7	3	1	3	4	0	0.645	1.000
385	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(3), GLB1(3), HEXB(1), LCT(15), SLC33A1(1), ST3GAL1(1), ST3GAL2(1), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC5(4), ST6GALNAC6(3), ST8SIA1(3), ST8SIA5(4)	3657306	44	25	44	15	20	8	2	9	5	0	0.647	1.000
386	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(5), PNPO(1), PSAT1(3)	1106092	9	8	9	5	4	4	0	0	1	0	0.654	1.000
387	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(2), ITGA4(3), ITGAL(5), ITGB1(6), ITGB2(4), PECAM1(1), SELE(2)	2841027	26	18	25	8	8	9	0	7	2	0	0.655	1.000
388	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10(3), ALG10B(4), ALG11(1), ALG12(2), ALG13(1), ALG2(3), ALG3(1), ALG5(2), ALG6(3), ALG8(5), ALG9(1), B4GALT1(5), B4GALT2(3), B4GALT3(6), DAD1(2), DDOST(2), DPAGT1(1), DPM1(1), FUT8(1), GANAB(4), MAN1A1(4), MAN1A2(2), MAN1B1(2), MAN1C1(4), MAN2A1(8), MGAT1(1), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(2), ST6GAL1(1), STT3B(4)	9381957	87	44	86	17	30	17	2	33	5	0	0.656	1.000
389	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(3), BAG4(2), CASP2(4), CASP3(1), CASP8(11), CRADD(1), DFFA(2), DFFB(2), LMNB1(2), LMNB2(1), MADD(13), MAP2K4(9), MAP3K1(6), MAP3K7(2), MAPK8(2), PAK1(4), PAK2(2), PRKDC(13), RB1(4), RIPK1(2), SPTAN1(9), TNFRSF1A(1), TRADD(1), TRAF2(1)	8410902	98	38	96	31	26	26	6	23	15	2	0.658	1.000
390	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), ACAT2(2), OXCT1(3)	773281	6	6	6	2	1	1	0	4	0	0	0.662	1.000
391	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(1), CD3D(1), CD3G(2), CD4(2)	642460	7	6	8	5	2	4	0	0	1	0	0.664	1.000
392	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPN1(2), CAPNS1(1), CAPNS2(1), CDK5R1(1), CSNK1A1(2), CSNK1D(3), GSK3B(7), MAPT(4), PPP2CA(1)	1918009	22	14	22	4	9	6	0	4	3	0	0.667	1.000
393	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(3), ADCY3(1), ADCY9(4), ARF4(2), ARF6(1), ARL4D(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V0D2(6), ATP6V1A(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ERO1L(1), GNAS(6), PDIA4(4), PLCG1(4), PLCG2(9), PRKCA(2), SEC61A1(5), SEC61A2(1), SEC61B(1), TRIM23(5)	8288239	79	39	75	27	38	19	3	13	6	0	0.673	1.000
394	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(5), GALNS(4), GLB1(3), GNS(1), GUSB(2), HEXB(1), IDS(2), IDUA(1), LCT(15), NAGLU(3)	3254815	37	22	37	10	16	6	2	9	4	0	0.679	1.000
395	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(5), ABP1(1), ACADM(3), ACADSB(5), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), AOC2(4), AOC3(4), CNDP1(3), DPYD(8), DPYS(6), ECHS1(2), EHHADH(2), GAD1(7), GAD2(4), HADHA(2), MLYCD(1), SDS(2), SMS(2), UPB1(3)	6527462	92	34	92	16	34	25	1	25	7	0	0.680	1.000
396	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CCNH(2), CDC25A(2), CDC25B(5), CDC25C(3), CDK7(1), MNAT1(1), XPO1(1)	2008281	17	12	17	7	5	5	0	6	1	0	0.681	1.000
397	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(2), CBS(2), CTH(1), MUT(3)	1117684	9	8	9	1	4	2	0	0	3	0	0.681	1.000
398	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), CYP11A1(2), CYP11B1(5), CYP11B2(5), CYP17A1(2), HSD11B1(1), HSD3B1(2)	1955432	19	14	19	6	11	4	0	4	0	0	0.682	1.000
399	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), CYP11A1(2), CYP11B1(5), CYP11B2(5), CYP17A1(2), HSD11B1(1), HSD3B1(2)	1955432	19	14	19	6	11	4	0	4	0	0	0.682	1.000
400	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2A1(2), AP2M1(4), BAD(1), BTK(6), EEA1(5), GRASP(1), GSK3A(2), GSK3B(7), LYN(4), PDPK1(1), PFKL(1), PFKM(1), PFKP(2), PLCG1(4), PRKCE(4), RPS6KB1(3), VAV2(2)	5563795	52	29	52	12	21	14	1	7	8	1	0.682	1.000
401	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(2), ARSB(5), ARSD(3), ARSE(2), CYP11B1(5), CYP11B2(5), HSD11B1(1), HSD17B2(1), HSD17B3(1), HSD17B8(1), HSD3B1(2), SRD5A1(1), SRD5A2(1), STS(6), SULT1E1(1), SULT2A1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2B15(2), UGT2B4(2)	5811271	57	29	57	8	29	10	1	10	7	0	0.689	1.000
402	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(4), GRB2(2), IL2(3), IL2RA(2), IL2RB(1), JAK1(3), JAK3(6), LCK(2), MAP2K1(3), MAPK3(2), MAPK8(2), RAF1(4), SHC1(3), SOS1(5), STAT5B(2)	5226699	44	26	41	16	14	11	4	12	3	0	0.689	1.000
403	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(4), GAD1(7), HDC(3), TPH1(1)	1334752	15	12	15	6	6	2	1	6	0	0	0.690	1.000
404	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(1), ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A3(4), ALDH3A1(2), ALDH3B1(2), ALDH3B2(1), AOC2(4), AOC3(4), AOX1(5), CARM1(2), DBH(4), DCT(9), DDC(1), ECH1(1), ESCO1(7), ESCO2(3), FAH(1), GOT1(5), GOT2(1), GSTZ1(2), HGD(1), HPD(3), LCMT1(1), LCMT2(2), MAOA(2), METTL2B(1), METTL6(5), MYST3(13), MYST4(5), PNPLA3(4), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), SH3GLB1(3), TAT(3), TPO(8), TYR(2), TYRP1(2), WBSCR22(1)	12994415	145	49	144	56	58	37	3	40	7	0	0.691	1.000
405	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(2), ITGAL(5), ITGAM(5), ITGB2(4), PECAM1(1), SELE(2)	2380691	22	16	22	6	8	8	0	4	2	0	0.695	1.000
406	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), ACAT2(2), ACYP1(1), ECHS1(2), EHHADH(2), GCDH(3), HADHA(2), SDHB(2), SDS(2)	1765483	17	11	17	1	5	3	0	5	4	0	0.695	1.000
407	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADK(1), ADSL(7), ADSS(1), AK5(4), ALLC(3), AMPD1(7), AMPD2(4), AMPD3(2), ATIC(4), ATP1B1(1), ATP5A1(2), ATP5B(4), ATP5C1(2), ATP5D(1), ATP5F1(1), ATP5G3(1), ATP5J2(1), DCK(1), ENPP1(4), ENPP3(3), ENTPD1(2), FHIT(1), GART(3), GMPS(5), GUCY1A2(8), GUCY1A3(12), GUCY1B3(7), GUCY2C(7), GUCY2D(4), GUCY2F(7), HPRT1(2), IMPDH1(1), IMPDH2(1), ITPA(2), NPR1(6), NPR2(9), NT5E(2), NT5M(1), PAPSS1(1), PAPSS2(2), PDE1A(3), PDE4A(4), PDE4B(2), PDE4C(2), PDE4D(3), PDE5A(3), PDE6B(5), PDE6C(8), PDE7B(3), PDE8A(1), PDE9A(5), PFAS(1), PKM2(2), POLB(1), POLD1(5), POLD2(1), POLE(17), POLG(4), POLQ(8), POLR1B(6), POLR2A(6), POLR2B(5), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLRMT(1), PPAT(3), PRPS1L1(1), PRPS2(2), RRM1(1), RRM2(2)	28743335	297	74	293	87	101	71	8	80	37	0	0.696	1.000
408	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(1), PSMA3(2), PSMA4(2), PSMA5(1), PSMB2(2), PSMB5(2), PSMB6(2), PSMC2(1), PSMC3(3), PSMD1(4), PSMD11(3), PSMD12(2), PSMD13(1), PSMD2(3), PSMD6(2)	3679575	32	22	32	15	10	7	2	10	3	0	0.701	1.000
409	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CASP2(4), CHUK(4), CRADD(1), IKBKB(2), MAP2K3(2), MAP2K4(9), MAP2K6(2), MAP3K1(6), MAP3K14(2), MAPK14(3), MAPK8(2), NFKB1(3), RELA(2), RIPK1(2), TANK(3), TNFRSF1A(1), TRADD(1), TRAF2(1)	5360717	51	27	50	18	20	14	5	8	4	0	0.705	1.000
410	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(4), CARS(5), DARS(3), EPRS(10), FARS2(4), GARS(3), HARS(2), IARS(5), KARS(3), LARS(4), LARS2(2), MARS(3), NARS(2), QARS(7), RARS(2), SARS(1), TARS(3), WARS(1), WARS2(2), YARS(2)	7296707	68	33	68	11	27	15	1	18	7	0	0.711	1.000
411	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(5), EGF(3), EGFR(10), TF(7), TFRC(2)	2953464	27	18	27	6	14	4	1	5	2	1	0.712	1.000
412	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), CREM(4), MAPK3(2), OPRK1(5), POLR2A(6), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2)	2819144	25	18	25	5	12	6	1	5	1	0	0.714	1.000
413	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(5), ALAS2(5), CPO(3), FECH(2), GATA1(4), HBB(2), HMBS(2), UROS(1)	1854085	24	14	24	5	13	5	0	5	1	0	0.714	1.000
414	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX5(4), CYP1A2(2), CYP2C19(4), CYP2C8(2), CYP2C9(4), CYP2E1(5), CYP2J2(3), CYP3A4(1), CYP3A5(3), CYP3A7(4), HSD3B7(2), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), RDH12(2), RDH13(1)	5411937	46	26	46	22	17	10	1	15	2	1	0.716	1.000
415	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(3), UBE2A(2), UBE2B(2), UBE2C(2), UBE2D1(1), UBE2E1(3), UBE2G1(2), UBE2I(1), UBE2J2(1), UBE2L3(2), UBE3A(6)	2340485	25	14	25	10	7	2	2	9	5	0	0.717	1.000
416	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(1), ALDH1A3(4), ALDH3A1(2), ALDH3B1(2), ALDH3B2(1), AOC2(4), AOC3(4), DDC(1), EPX(6), ESCO1(7), ESCO2(3), GOT1(5), GOT2(1), HPD(3), LPO(2), MAOA(2), MPO(3), MYST3(13), MYST4(5), PNPLA3(4), PRDX6(2), SH3GLB1(3), TAT(3), TPO(8)	7618227	89	39	88	26	45	22	1	16	5	0	0.717	1.000
417	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(2), FUT1(1), FUT2(1), FUT3(3), FUT6(1), ST3GAL3(4)	1019671	12	9	12	4	7	2	0	3	0	0	0.718	1.000
418	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(6), HK2(3), HK3(4), IMPA1(2), PGM1(2), PGM3(4)	2304758	22	16	22	11	6	6	0	10	0	0	0.718	1.000
419	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(6), HK2(3), HK3(4), IMPA1(2), IMPA2(2), PGM1(2), PGM3(4)	2615706	24	18	24	11	7	6	0	10	1	0	0.719	1.000
420	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA3(3), GGT1(3), SHMT1(1), SHMT2(2)	1137708	9	9	7	6	2	4	0	0	3	0	0.721	1.000
421	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP4(1), BMP5(4), BMP6(3), BMP7(5), BMP8A(1), BTRC(2), CSNK1A1(2), CSNK1A1L(5), CSNK1D(3), CSNK1G1(1), CSNK1G3(2), DHH(1), FBXW11(7), GLI1(3), GLI2(2), GLI3(9), GSK3B(7), HHIP(4), IHH(1), LRP2(39), PRKACB(1), PRKACG(2), PRKX(2), PTCH1(8), PTCH2(4), RAB23(1), STK36(4), SUFU(4), WNT1(1), WNT10B(3), WNT11(3), WNT16(2), WNT2B(1), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT7A(2), WNT7B(2), WNT8A(1), WNT9A(2), WNT9B(1), ZIC2(1)	13405539	156	56	155	70	71	33	2	32	18	0	0.721	1.000
422	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(3), RAB27A(2), RAB3A(2), RAB4A(1), RAB6A(2)	939684	10	8	10	2	3	6	0	1	0	0	0.731	1.000
423	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(1), PSMA3(2), PSMA4(2), PSMA5(1), PSMB2(2), PSMB5(2), PSMB6(2), PSMB9(4)	1998179	17	14	17	6	6	3	2	3	3	0	0.737	1.000
424	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(2), ACOX1(3), ACOX3(5), ELOVL2(3), ELOVL5(1), ELOVL6(1), FADS2(3), FASN(1), HADHA(2), HSD17B12(2), SCD(2)	3282086	25	19	25	4	11	6	1	4	3	0	0.738	1.000
425	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(5), CHIT1(4), CMAS(5), CTBS(4), CYB5R1(1), CYB5R3(1), GFPT1(3), GFPT2(3), GNE(2), GNPDA2(1), HEXB(1), HK1(6), HK2(3), HK3(4), LHPP(1), MTMR1(4), MTMR2(1), MTMR6(4), NAGK(2), NPL(2), PGM3(4), PHPT1(1), RENBP(1)	6495567	63	33	63	17	25	17	0	16	5	0	0.739	1.000
426	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(3), CD34(1), CD3D(1), CD3G(2), CD4(2), CD58(1), IL3(3), IL6(1), KITLG(2)	1443001	16	10	15	6	5	6	0	4	1	0	0.740	1.000
427	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(4), ASPH(2), CREB1(1), EDN1(1), EP300(13), HIF1A(1), LDHA(1), NOS3(2), P4HB(2)	3793446	27	21	27	10	8	11	0	6	2	0	0.749	1.000
428	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(5), ALAS2(5), FECH(2), HMBS(2), PPOX(3), UROS(1)	1751382	18	12	18	3	10	3	0	4	1	0	0.750	1.000
429	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(1), CASP7(1), DFFA(2), DFFB(2), GZMB(1), HMGB1(1), HMGB2(1), TOP2A(2), TOP2B(5)	1842185	16	12	15	4	3	4	0	8	1	0	0.750	1.000
430	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), ATIC(4), FTCD(2), GART(3), MTFMT(1), MTHFD1(6), MTHFD1L(6), MTHFR(6), MTHFS(1), MTR(6), SHMT1(1), SHMT2(2), TYMS(2)	4240150	43	25	43	11	18	9	0	11	5	0	0.752	1.000
431	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(4), IKBKB(2), IRAK1(1), LY96(2), MAP2K3(2), MAP2K4(9), MAP2K6(2), MAP3K1(6), MAP3K14(2), MAP3K7(2), MAPK14(3), MAPK8(2), MYD88(1), NFKB1(3), PPARA(1), RELA(2), TIRAP(1), TLR10(1), TLR2(2), TLR3(4), TLR4(7), TLR6(2), TLR7(4), TLR9(4), TOLLIP(1), TRAF6(4)	7961833	75	34	74	26	27	14	5	21	8	0	0.752	1.000
432	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(1), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), AOC2(4), AOC3(4), ASPA(3), CNDP1(3), DDC(1), HAL(3), HARS(2), HDC(3), HNMT(4), MAOA(2), PRPS2(2)	5415728	63	31	63	15	26	19	0	17	1	0	0.752	1.000
433	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(2), EHHADH(2), HADH(1), HADHA(2), HSD17B10(1), HSD17B4(3), NTAN1(3), SIRT1(4), SIRT2(1), SIRT5(1), SIRT7(1), VNN2(1)	2666211	22	17	22	8	8	7	0	2	5	0	0.755	1.000
434	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1B(2), ADH1C(3), ADH4(1), ADH6(5), ADH7(2), ADHFE1(6), AGPAT1(1), AGPAT3(3), AGPAT4(6), AKR1B1(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), CEL(1), DGKA(1), DGKB(7), DGKD(9), DGKE(1), DGKG(3), DGKH(5), DGKZ(2), GK(3), GLA(4), GLB1(3), LCT(15), LIPC(3), LIPF(1), LIPG(2), LPL(6), PNLIP(5), PNLIPRP1(4), PNLIPRP2(1), PPAP2B(1)	10636871	136	43	135	36	43	31	2	49	11	0	0.755	1.000
435	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(2), ACADM(3), ACADSB(5), ACAT1(1), ACAT2(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(3), ALDH9A1(1), AOX1(5), BCAT1(1), BCKDHA(3), BCKDHB(1), ECHS1(2), EHHADH(2), HADHA(2), HADHB(1), MCCC1(7), MCCC2(2), MCEE(1), MUT(3), OXCT1(3), PCCA(3), PCCB(3), SDS(2)	8179982	85	37	85	18	33	19	0	24	9	0	0.762	1.000
436	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(1), CAMK1G(3), FPR1(2), GNA15(3), GNB1(1), MAP2K1(3), MAP2K3(2), MAP2K6(2), MAP3K1(6), MAPK1(2), MAPK14(3), MAPK3(2), NCF1(1), NCF2(1), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NFKB1(3), PAK1(4), PIK3C2G(7), PLCB1(8), PPP3CA(1), PPP3CB(4), PPP3CC(3), RAF1(4), RELA(2), SYT1(1)	8462003	81	37	80	27	31	16	3	16	15	0	0.768	1.000
437	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(1), CD3D(1), CD3G(2), ICAM1(2), ITGAL(5), ITGB2(4), PTPRC(9)	2394233	27	17	27	9	6	10	0	6	5	0	0.771	1.000
438	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS1(1), DHRS2(2), DHRS3(2), ESCO1(7), ESCO2(3), MYST3(13), MYST4(5), PNPLA3(4), SH3GLB1(3)	3609005	40	21	40	13	19	10	1	6	4	0	0.772	1.000
439	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL2(1), IFNAR1(3), IFNAR2(1), IFNB1(1), MAPK8(2), NFKB1(3), RELA(2), TNFRSF11A(2), TNFSF11(1), TRAF6(4)	2474213	20	14	20	7	7	7	0	1	5	0	0.772	1.000
440	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(1), CD3D(1), CD3G(2), CD4(2), ICAM1(2), ITGAL(5), ITGB2(4), PTPRC(9)	2530710	29	18	29	11	6	12	0	6	5	0	0.773	1.000
441	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(3), ACO2(2), FH(1), IDH1(3), IDH2(7), IDH3A(1), IDH3G(2), MDH1(1), MDH2(1), PC(3), SDHA(5), SDHB(2), SUCLA2(3), SUCLG1(1)	4559430	35	25	35	13	17	7	0	7	4	0	0.774	1.000
442	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(4), DYRK1B(4), GLI2(2), GLI3(9), GSK3B(7), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), SUFU(4)	3624283	37	23	37	21	18	9	2	3	5	0	0.776	1.000
443	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), CPS1(8), GLUD1(2), GOT1(5)	1722990	16	10	16	4	4	5	0	4	3	0	0.777	1.000
444	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), IDI1(1), SQLE(1)	671672	4	4	4	3	1	2	0	0	1	0	0.778	1.000
445	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(3), EGFR(10), MAP2K1(3), MAP3K1(6), MAPK14(3), NCOR2(2), RXRA(1), THRA(2), THRB(4)	3852603	34	21	34	13	17	7	2	6	2	0	0.779	1.000
446	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(4), AARS2(6), CARS(5), CARS2(1), DARS(3), DARS2(2), EPRS(10), FARS2(4), FARSA(1), FARSB(7), GARS(3), HARS(2), HARS2(2), IARS(5), IARS2(6), KARS(3), LARS(4), LARS2(2), MARS(3), MTFMT(1), NARS(2), NARS2(3), QARS(7), RARS(2), RARS2(3), SARS(1), SARS2(2), TARS(3), TARS2(4), VARS(1), VARS2(6), WARS(1), WARS2(2), YARS(2), YARS2(3)	12243810	116	44	116	19	45	23	2	30	16	0	0.779	1.000
447	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(2), GRIN1(1), GRIN2A(15), GRIN2B(8), GRIN2C(2), GRIN2D(3), NOS1(5), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), SYT1(1)	5585619	54	29	54	31	25	12	1	9	7	0	0.787	1.000
448	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), BLVRB(1), HMOX1(2), IL10(1), IL10RA(1), IL10RB(4), IL1A(1), IL6(1), JAK1(3), STAT1(6), STAT3(2)	2708425	24	16	22	16	10	4	1	8	1	0	0.790	1.000
449	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1), RANBP2(8), RANGAP1(1)	1717595	10	8	10	1	4	1	1	0	4	0	0.793	1.000
450	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(7), ADSS(1), HPRT1(2), IMPDH1(1), POLB(1), POLD1(5), POLG(4), PRPS2(2), RRM1(1)	2788374	24	19	24	9	11	5	0	7	1	0	0.793	1.000
451	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(2), B3GALT1(1), B3GALT2(3), B3GALT5(2), B3GNT5(1), FUT1(1), FUT2(1), FUT3(3), ST3GAL3(4), ST3GAL4(2)	1559353	20	13	20	3	9	4	0	5	2	0	0.795	1.000
452	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(5), GALNS(4), GLB1(3), GNS(1), GUSB(2), HEXB(1), HGSNAT(6), HPSE(2), HPSE2(9), IDS(2), IDUA(1), LCT(15), NAGLU(3), SPAM1(1)	4565629	55	26	54	15	20	9	2	17	7	0	0.796	1.000
453	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(5), ABP1(1), ACADM(3), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), AOC2(4), AOC3(4), CNDP1(3), DPYD(8), DPYS(6), ECHS1(2), EHHADH(2), GAD1(7), GAD2(4), HADHA(2), MLYCD(1), SMS(2), UPB1(3)	6061630	77	31	77	17	28	21	1	21	6	0	0.796	1.000
454	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(3), CBS(2), CTH(1), GGT1(3), MARS(3), MAT1A(5), MAT2B(2), PAPSS1(1), PAPSS2(2), SCLY(1), SEPHS1(1)	2745454	24	16	22	9	11	7	1	4	1	0	0.797	1.000
455	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS1(3), ACSS2(5), ACYP1(1), ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(1), DLAT(2), ENO2(3), ENO3(3), FBP2(2), G6PC(3), GALM(2), GCK(1), GPI(1), HK1(6), HK2(3), HK3(4), LDHA(1), LDHAL6A(2), LDHAL6B(1), LDHB(1), LDHC(2), PDHA1(4), PDHA2(6), PDHB(2), PFKL(1), PFKM(1), PFKP(2), PGAM1(3), PGAM2(1), PGK1(3), PGK2(6), PGM1(2), PGM3(4), PKM2(2), TPI1(1)	12729919	134	49	133	40	46	33	1	46	8	0	0.799	1.000
456	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(14), ACAT1(1), ACAT2(2), ACYP1(1), ADH5(1), AKR1B1(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), DLAT(2), LDHA(1), LDHB(1), LDHC(2), LDHD(1), MDH1(1), MDH2(1), ME1(7), ME2(3), ME3(4), PC(3), PDHA1(4), PDHA2(6), PDHB(2), PKM2(2)	8286323	89	36	89	22	32	23	1	23	10	0	0.805	1.000
457	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(1), CA1(1), CA13(1), CA14(2), CA2(1), CA3(1), CA4(1), CA5A(1), CA6(2), CA8(2), CA9(2), CPS1(8), CTH(1), GLS2(2), GLUD1(2), GLUD2(4), GLUL(3), HAL(3)	4751377	38	25	38	20	16	10	0	5	7	0	0.809	1.000
458	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(3), CARM1(2), CBS(2), CTH(1), GGT1(3), LCMT1(1), LCMT2(2), MARS(3), MAT1A(5), MAT2B(2), METTL2B(1), METTL6(5), PAPSS1(1), PAPSS2(2), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), SCLY(1), SEPHS1(1), SEPHS2(3), WBSCR22(1)	5418630	49	28	47	18	18	14	1	13	3	0	0.811	1.000
459	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(8), AMY2A(3), ENPP1(4), ENPP3(3), G6PC(3), GANAB(4), GBA3(3), GBE1(4), GCK(1), GPI(1), GUSB(2), GYS1(1), GYS2(8), HK1(6), HK2(3), HK3(4), MGAM(9), PGM1(2), PGM3(4), PYGB(4), PYGL(2), PYGM(2), SI(12), UCHL1(1), UCHL3(1), UGDH(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2B15(2), UGT2B4(2), UXS1(6)	12134352	123	47	123	44	42	34	0	32	15	0	0.812	1.000
460	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), AKT2(5), ARHGEF11(9), BCL2(1), DLG4(2), GNA13(2), LPA(9), MAP2K4(9), MAP3K1(6), MAP3K5(5), MAPK8(2), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PHKA2(5), PIK3CB(2), PLD1(8), PLD2(1), PLD3(5), PTK2(5), RDX(2), ROCK1(8), ROCK2(2), SERPINA4(2), SRF(3)	10818556	103	43	102	34	42	20	2	27	12	0	0.812	1.000
461	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(2), EHHADH(2), HADHA(2), SDS(2)	1109940	8	6	8	1	3	2	0	0	3	0	0.819	1.000
462	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(5), CD2(3), CD33(1), CD5(2), CD7(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL12B(2), IL13(1), IL3(3), IL4(3), ITGAX(4), TLR2(2), TLR4(7), TLR7(4), TLR9(4)	4101271	46	22	45	19	18	7	4	15	2	0	0.820	1.000
463	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT1(1), ACAT2(2), ACOT11(3), ACYP1(1), DHRS1(1), DHRS2(2), DHRS3(2), ECHS1(2), EHHADH(2), ESCO1(7), ESCO2(3), GCDH(3), HADHA(2), ITGB1BP3(1), MYST3(13), MYST4(5), PNPLA3(4), SH3GLB1(3), YOD1(1)	5735998	58	29	58	16	25	14	1	10	8	0	0.828	1.000
464	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(2), ITGA4(3), ITGAL(5), ITGAM(5), ITGB1(6), ITGB2(4), PECAM1(1), SELE(2), SELP(4)	3585058	35	19	34	10	12	10	0	10	3	0	0.829	1.000
465	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BET1(1), BNIP1(1), GOSR1(2), GOSR2(2), SEC22B(2), SNAP23(1), SNAP25(1), SNAP29(3), STX11(1), STX12(3), STX16(3), STX19(1), STX2(2), STX3(2), STX4(2), STX5(3), STX6(1), STX7(2), STX8(2), TSNARE1(1), VAMP1(1), VAMP3(1), VAMP4(2), VAMP5(2), VAMP8(1), VTI1A(1), VTI1B(1)	3656686	45	22	44	14	19	4	0	12	10	0	0.830	1.000
466	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(2), HADH(1), HADHA(2), HADHB(1), HSD17B10(1), HSD17B4(3), MECR(1), PPT2(1)	1955404	12	10	12	5	2	2	0	3	5	0	0.831	1.000
467	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(3)	406881	3	3	3	2	2	0	0	0	1	0	0.833	1.000
468	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(4), GRB2(2), JAK2(6), MAP2K1(3), MAPK3(2), MAPK8(2), PLCG1(4), PTPN6(4), RAF1(4), SHC1(3), SOS1(5), STAT5B(2)	4816101	41	22	39	11	16	8	4	9	3	1	0.833	1.000
469	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX12(2), ALOX5(4), CYP4F2(8), CYP4F3(2), EPX(6), GGT1(3), LPO(2), MPO(3), PLA2G1B(1), PLA2G4A(5), PLA2G6(2), PRDX6(2), PTGIS(4), PTGS1(4), PTGS2(2), TBXAS1(5), TPO(8)	6193955	63	33	60	21	30	13	0	16	4	0	0.834	1.000
470	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADM(3), ACADVL(1), ACSL1(3), ACSL3(6), ACSL4(4), CPT1A(5), CPT2(1), EHHADH(2), HADHA(2), SCP2(3), SLC25A20(1)	3827170	31	19	31	11	9	8	0	10	4	0	0.836	1.000
471	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CDKN1A(1), GNAQ(3), MARCKS(1), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKCA(2), SP1(2), SP3(2), SYT1(1)	4644159	36	26	36	12	14	4	0	10	8	0	0.838	1.000
472	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(3), ACO2(2), HAO1(5), HAO2(3), HYI(1), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(6)	2897069	28	17	27	8	11	5	0	10	2	0	0.838	1.000
473	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(3), ACOX3(5), FADS2(3), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2)	2336103	20	13	20	6	8	5	1	4	2	0	0.841	1.000
474	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(3), CD3D(1), CD3G(2), GZMB(1), HLA-A(1), ICAM1(2), ITGAL(5), ITGB2(4)	1874734	19	14	19	5	5	5	0	3	6	0	0.843	1.000
475	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(3), AADAC(2), ABAT(5), ACAT1(1), ACAT2(2), ACSM1(3), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH5A1(4), ALDH7A1(1), ALDH9A1(1), BDH1(1), DDHD1(1), ECHS1(2), EHHADH(2), GAD1(7), GAD2(4), HADH(1), HADHA(2), HMGCS1(1), HSD17B10(1), HSD17B4(3), HSD3B7(2), ILVBL(2), L2HGDH(3), OXCT1(3), OXCT2(1), PDHA1(4), PDHA2(6), PDHB(2), PLA1A(3), PPME1(2), PRDX6(2), RDH12(2), RDH13(1)	9221022	98	39	98	27	41	25	0	23	9	0	0.846	1.000
476	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADM(3), ACAT1(1), ECHS1(2), HADHA(2)	1230053	8	6	8	2	0	2	0	2	4	0	0.846	1.000
477	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(6), KHK(1), LCT(15), MPI(1), PGM1(2), PYGL(2), PYGM(2), TPI1(1), TREH(2)	2956045	32	21	32	13	10	10	1	11	0	0	0.847	1.000
478	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACAA1(2), ACADM(3), ACOX1(3), ACOX2(2), ACOX3(5), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(5), ADIPOQ(4), APOA2(1), APOA5(1), AQP7(1), CD36(1), CPT1A(5), CPT1B(5), CPT2(1), CYP27A1(3), CYP4A11(2), CYP4A22(2), CYP7A1(4), CYP8B1(2), EHHADH(2), FABP1(1), FABP2(1), FABP3(1), FABP4(1), FABP5(1), FABP6(1), FADS2(3), GK(3), GK2(3), LPL(6), ME1(7), MMP1(1), NR1H3(4), OLR1(1), PCK2(3), PDPK1(1), PLTP(5), PPARA(1), PPARD(1), PPARG(1), RXRA(1), RXRB(2), RXRG(3), SCD(2), SCP2(3), SLC27A1(2), SLC27A2(2), SLC27A4(1), SLC27A5(3), SLC27A6(4), SORBS1(7), UCP1(1)	14600391	148	52	147	48	42	39	3	48	16	0	0.849	1.000
479	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), ATIC(4), GART(3), MTHFD1(6), MTHFD1L(6), MTHFR(6), MTHFS(1), MTR(6), SHMT1(1), SHMT2(2), TYMS(2)	4047718	40	23	40	10	17	9	0	11	3	0	0.849	1.000
480	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(9), CAPN2(5), CAPNS1(1), CAPNS2(1), EP300(13), HDAC1(2), HDAC2(2), MEF2D(1), NFATC1(1), NFATC2(3), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKCA(2), SYT1(1)	5422412	49	27	49	12	20	12	1	7	9	0	0.850	1.000
481	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(1), IL13RA2(2), IL4R(1), JAK1(3), JAK2(6), TYK2(1)	2300981	15	13	14	6	7	0	2	4	1	1	0.851	1.000
482	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(1), IL13RA2(2), IL4R(1), JAK1(3), JAK2(6), TYK2(1)	2300981	15	13	14	6	7	0	2	4	1	1	0.851	1.000
483	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1B(2), ADH1C(3), ADH4(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(1), DLAT(2), ENO2(3), ENO3(3), FBP2(2), G6PC(3), GCK(1), GPI(1), HK1(6), HK2(3), HK3(4), LDHA(1), LDHB(1), LDHC(2), PDHA1(4), PDHA2(6), PDHB(2), PFKM(1), PFKP(2), PGAM1(3), PGK1(3), PGM1(2), PGM3(4), PKM2(2), TPI1(1)	10780789	120	44	119	32	40	31	1	42	6	0	0.852	1.000
484	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1B(2), ADH1C(3), ADH4(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(1), DLAT(2), ENO2(3), ENO3(3), FBP2(2), G6PC(3), GCK(1), GPI(1), HK1(6), HK2(3), HK3(4), LDHA(1), LDHB(1), LDHC(2), PDHA1(4), PDHA2(6), PDHB(2), PFKM(1), PFKP(2), PGAM1(3), PGK1(3), PGM1(2), PGM3(4), PKM2(2), TPI1(1)	10780789	120	44	119	32	40	31	1	42	6	0	0.852	1.000
485	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(3), CSF1(1), IL6R(2), SPN(1), TGFB1(1), TGFB2(5), TNFRSF1A(1), TNFRSF8(1), TNFSF8(1)	2999410	18	13	18	10	5	4	1	4	4	0	0.852	1.000
486	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(3), CAPN1(2), CAPN2(5), CAPNS1(1), CAPNS2(1), EGF(3), EGFR(10), ITGA1(3), ITGB1(6), MAPK1(2), MAPK3(2), MYL2(1), MYLK(11), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PTK2(5), TLN1(5)	7238657	67	34	67	18	28	18	2	15	4	0	0.852	1.000
487	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(2), B4GALT1(5), B4GALT2(3), B4GALT3(6), B4GALT5(2), DDOST(2), DPAGT1(1), DPM1(1), FUT8(1), MAN1A1(4), MAN1B1(2), MGAT1(1), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), ST6GAL1(1)	4429180	40	26	40	10	18	8	2	11	1	0	0.855	1.000
488	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(3), AK3(1), CAD(10), CDA(1), CTPS(3), CTPS2(4), DCK(1), DCTD(3), DHODH(3), DPYD(8), DPYS(6), ENTPD1(2), ENTPD3(5), ENTPD4(5), ENTPD5(1), ENTPD6(1), ITPA(2), NME6(3), NME7(3), NT5C1A(1), NT5C1B(9), NT5C2(3), NT5C3(2), NT5E(2), NT5M(1), PNPT1(5), POLA1(5), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(17), POLE3(1), POLR1A(7), POLR1B(6), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(5), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR3A(7), POLR3B(6), POLR3GL(1), POLR3H(1), PRIM2(6), RFC5(2), RRM1(1), RRM2(2), TK1(1), TXNRD1(2), TXNRD2(2), TYMS(2), UCK2(1), UPB1(3), UPP2(1), UPRT(3)	18261551	194	57	193	47	55	57	4	56	22	0	0.855	1.000
489	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(1), PSMA3(2), PSMA4(2), PSMA5(1), PSMB2(2), PSMB5(2), PSMB6(2), PSMC3(3), UBE2A(2), UBE3A(6)	2930348	24	15	24	11	8	5	2	6	3	0	0.855	1.000
490	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(3), JAK2(6), JAK3(6), MAPK1(2), MAPK3(2), STAT3(2), TYK2(1)	2633821	22	15	21	9	9	4	1	5	2	1	0.857	1.000
491	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP1(2), ACP2(2), ACP5(1), ACPP(3), ALPI(2), ALPL(1), ALPP(1), CYP3A4(1), CYP3A5(3), CYP3A7(4), DHRS1(1), DHRS2(2), DHRS3(2), PON1(5), PON2(1), PON3(2)	3868730	33	19	32	13	13	5	4	6	4	1	0.860	1.000
492	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(7), CLOCK(5), CRY1(2), CRY2(1), CSNK1D(3), NPAS2(5), NR1D1(4), PER1(1), PER2(2), PER3(7)	3847778	37	22	36	8	18	7	0	10	2	0	0.860	1.000
493	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(2), ALOX15B(5), ALOX5(4), ALOX5AP(1), DPEP1(1), GGT1(3), PLA2G6(2), PTGIS(4), PTGS1(4), PTGS2(2), TBXAS1(5)	3370104	33	21	31	9	11	9	0	12	1	0	0.861	1.000
494	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), CAMKK1(1), CAMKK2(1), CREB1(1), SYT1(1)	2649326	17	13	17	12	6	5	2	3	1	0	0.863	1.000
495	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AADAT(1), ABP1(1), ACAT1(1), ACAT2(2), ACMSD(3), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), AOC2(4), AOC3(4), AOX1(5), CARM1(2), CAT(2), CYP1A1(6), CYP1A2(2), CYP1B1(2), DDC(1), ECHS1(2), EHHADH(2), GCDH(3), HAAO(2), HADH(1), HADHA(2), HSD17B10(1), HSD17B4(3), INMT(1), KMO(3), KYNU(6), LCMT1(1), LCMT2(2), LNX1(7), MAOA(2), METTL2B(1), METTL6(5), NFX1(5), OGDH(4), OGDHL(8), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), TDO2(2), TPH1(1), TPH2(5), WARS(1), WARS2(2), WBSCR22(1)	13417652	139	51	139	42	53	37	0	38	11	0	0.864	1.000
496	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	AKT1(2), AKT2(5), DAG1(4), GNAQ(3), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PHKA2(5), PIK3CB(2), PITX2(2), PLD1(8), PLD2(1), PLD3(5), VN1R1(4)	9605968	87	39	87	36	36	19	5	20	7	0	0.865	1.000
497	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(5), CYB5R3(1), GCK(1), GFPT1(3), GNE(2), GNPDA2(1), HEXB(1), HK1(6), HK2(3), HK3(4), PGM3(4), RENBP(1)	3860620	32	22	32	12	11	9	0	11	1	0	0.865	1.000
498	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(3), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), CYP2C19(4), CYP2C9(4), DHRS1(1), DHRS2(2), DHRS3(2), ECHS1(2), EHHADH(2), ESCO1(7), ESCO2(3), HADHA(2), MYST3(13), MYST4(5), PNPLA3(4), SH3GLB1(3), YOD1(1)	6880810	78	30	78	21	33	20	1	16	8	0	0.866	1.000
499	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), IDI1(1), IDI2(1), SQLE(1)	920154	5	5	5	4	1	2	0	0	2	0	0.867	1.000
500	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(2), ACADM(3), ACADSB(5), ACADVL(1), ACAT1(1), ACAT2(2), ACOX1(3), ACOX3(5), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(5), ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), CPT1A(5), CPT1B(5), CPT2(1), CYP4A11(2), CYP4A22(2), ECHS1(2), EHHADH(2), GCDH(3), HADH(1), HADHA(2), HADHB(1), HSD17B10(1), HSD17B4(3), PECI(1)	10960377	115	40	115	32	34	29	3	38	11	0	0.867	1.000
501	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(5), B4GALT2(3), FBP2(2), G6PC(3), GALE(1), GALK2(2), GALT(2), GANAB(4), GCK(1), GLA(4), GLB1(3), HK1(6), HK2(3), HK3(4), LCT(15), MGAM(9), PFKM(1), PFKP(2), PGM1(2), PGM3(4)	7106413	78	35	78	28	34	22	1	19	2	0	0.875	1.000
502	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(2), ABP1(1), AOC2(4), AOC3(4), CES1(4), DDHD1(1), ESCO1(7), ESCO2(3), LIPA(1), MYST3(13), MYST4(5), PLA1A(3), PNPLA3(4), PPME1(2), PRDX6(2), SH3GLB1(3)	5626099	59	27	59	18	26	17	1	10	5	0	0.878	1.000
503	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(13), ATP4B(1), ATP5O(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ATP7A(5), ATP7B(4), COX10(2), COX4I1(2), COX6A2(1), COX6C(1), COX7A1(1), NDUFA1(1), NDUFA10(2), NDUFA4(1), NDUFB2(1), NDUFB6(1), NDUFS1(4), NDUFV1(2), PPA2(1), SDHA(5), SDHB(2), SHMT1(1), UQCRB(2), UQCRC1(2), UQCRFS1(1), UQCRH(1)	8133318	85	35	84	22	34	28	1	16	6	0	0.881	1.000
504	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(3), ACO2(2), HAO1(5), HAO2(3), HYI(1), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(6)	3033890	28	17	27	8	11	5	0	10	2	0	0.881	1.000
505	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(1), ALDOB(5), ALDOC(1), FBP2(2), FPGT(3), GCK(1), GMDS(1), GMPPA(6), HK1(6), HK2(3), HK3(4), KHK(1), MPI(1), PFKFB1(6), PFKFB4(2), PFKM(1), PFKP(2), PMM1(1), TPI1(1)	5398793	50	31	50	22	19	11	0	17	3	0	0.882	1.000
506	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CCR5(1), CXCL12(1), CXCR4(3), GNAQ(3), MAPK14(3), MAPK8(2), PLCG1(4), PRKCA(2), PTK2B(1), SYT1(1)	2998488	21	17	22	9	6	6	0	5	4	0	0.882	1.000
507	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(5), ALAS2(5), BLVRA(2), BLVRB(1), COX10(2), COX15(1), CP(3), EPRS(10), FECH(2), FTMT(3), GUSB(2), HCCS(1), HMBS(2), HMOX1(2), HMOX2(1), MMAB(1), PPOX(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2A1(8), UGT2A3(5), UGT2B10(1), UGT2B11(4), UGT2B15(2), UGT2B17(4), UGT2B28(2), UGT2B4(2), UGT2B7(4), UROS(1)	8879587	94	34	92	21	25	26	1	32	10	0	0.884	1.000
508	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), BCAT2(1), DPYD(8), DPYS(6), ENPP1(4), ENPP3(3), ILVBL(2), PANK1(2), PANK3(2), PANK4(1), PPCS(1), UPB1(3), VNN1(5)	3874437	39	21	39	11	10	14	2	10	3	0	0.885	1.000
509	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(3), ACTR2(1), ACTR3(2), AKT1(2), ANGPTL2(8), CFL1(1), FLNA(2), FLNC(11), FSCN3(2), GDI1(1), GDI2(1), LIMK1(4), MYH2(9), MYLK(11), MYLK2(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PFN2(1), RHO(2), ROCK1(8), ROCK2(2), RPS4X(1), VASP(3), WASF1(1), WASL(5)	10466462	97	40	97	31	28	25	4	28	12	0	0.885	1.000
510	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(2), RPE(2), UCHL1(1), UCHL3(1), UGDH(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2B15(2), UGT2B4(2)	3633569	30	18	30	10	13	8	0	4	5	0	0.886	1.000
511	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(14), ACACB(14), ACAT1(1), ACAT2(2), ACOT12(6), ACSS1(3), ACSS2(5), ACYP1(1), AKR1B1(2), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), DLAT(2), LDHA(1), LDHAL6A(2), LDHAL6B(1), LDHB(1), LDHC(2), LDHD(1), MDH1(1), MDH2(1), ME1(7), ME2(3), ME3(4), PC(3), PCK2(3), PDHA1(4), PDHA2(6), PDHB(2), PKM2(2)	10568226	114	41	114	31	42	27	1	30	14	0	0.886	1.000
512	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(4), NR1H3(4), NR1H4(1), RXRA(1)	1186453	11	9	11	7	4	6	0	1	0	0	0.887	1.000
513	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT3(3), AGPAT4(6), AGPAT6(1), AGPS(2), ENPP2(10), ENPP6(1), PAFAH1B1(3), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PLD1(8), PLD2(1), PPAP2B(1)	5336176	46	26	45	21	17	13	1	12	3	0	0.889	1.000
514	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(6), NR3C1(3), PPARG(1), RXRA(1)	1298420	12	8	12	9	1	2	0	7	2	0	0.890	1.000
515	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(2), ACP2(2), ACP5(1), ACPP(3), ENPP1(4), ENPP3(3), FLAD1(1), LHPP(1), MTMR1(4), MTMR2(1), MTMR6(4), PHPT1(1), TYR(2)	3411607	29	18	28	13	10	7	1	8	3	0	0.891	1.000
516	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(7), BCL2(1), BID(1), BIRC2(2), BIRC3(2), CASP10(2), CASP3(1), CASP6(1), CASP7(1), CASP8(11), CASP9(2), CFLAR(2), CHUK(4), DFFA(2), DFFB(2), GAS2(2), MAP3K14(2), NFKB1(3), RELA(2), RIPK1(2), SPTAN1(9), TNFRSF10A(3), TNFRSF10B(2), TNFSF10(1), TNFSF12(2), TRADD(1), TRAF2(1)	7522707	71	35	70	27	23	18	1	20	8	1	0.894	1.000
517	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(2), ACP2(2), ACP5(1), ACPP(3), ENPP1(4), ENPP3(3), FLAD1(1), TYR(2)	2184890	18	12	17	7	7	5	1	4	1	0	0.895	1.000
518	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(3), APAF1(7), BCL2(1), CASP3(1), CASP9(2), FASLG(1), HSPB2(1), IL1A(1), MAPKAPK2(3), MAPKAPK3(1)	2536946	21	15	21	10	6	6	0	6	3	0	0.897	1.000
519	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(2), CDK7(1), ERCC3(6), GTF2B(1), GTF2E1(5), GTF2H1(2), GTF2H4(1), MNAT1(1), POLR1A(7), POLR1B(6), POLR2A(6), POLR2B(5), POLR2E(1), POLR2H(1), POLR2I(1), POLR3B(6), POLR3D(3), POLR3E(3), POLR3H(1), TAF5(3), TAF6(2), TAF7(1), TBP(1)	7988114	66	33	66	22	23	23	1	14	5	0	0.898	1.000
520	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	CREB1(1), GRB2(2), HSPB2(1), MAP2K4(9), MAP2K6(2), MAP3K1(6), MAP3K5(5), MAP3K7(2), MAP3K9(2), MAPK14(3), MAPKAPK2(3), MAPKAPK5(1), MAX(1), MEF2A(3), MEF2C(7), MEF2D(1), MKNK1(1), PLA2G4A(5), RIPK1(2), RPS6KA5(3), SHC1(3), STAT1(6), TGFB1(1), TGFB2(5), TGFBR1(6), TRADD(1), TRAF2(1)	8074652	83	32	80	25	31	22	3	18	9	0	0.898	1.000
521	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), DPYD(8), DPYS(6), ENPP1(4), ENPP3(3), PANK1(2), PANK3(2), PANK4(1), PPCS(1), UPB1(3)	3111342	31	17	31	7	6	12	1	9	3	0	0.898	1.000
522	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(2), ACAT1(1), ACAT2(2), ECHS1(2), EHHADH(2), HADHA(2), HADHB(1), SDS(2)	1911177	14	10	14	2	3	5	0	3	3	0	0.901	1.000
523	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(2), DLAT(2), FH(1), IDH2(7), IDH3A(1), IDH3G(2), MDH1(1), MDH2(1), OGDH(4), PC(3), PDHA1(4), PDHA2(6), PDHB(2), PDHX(2), PDK2(1), PDK4(2), SDHA(5), SDHB(2), SDHD(1), SUCLA2(3), SUCLG1(1)	6350188	53	29	53	17	25	11	0	8	9	0	0.903	1.000
524	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(2), DHRS1(1), DHRS2(2), DHRS3(2), LCMT1(1), LCMT2(2), METTL2B(1), METTL6(5), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), WBSCR22(1)	3101478	27	17	27	12	9	6	0	8	4	0	0.903	1.000
525	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(3), FUCA1(1), GLB1(3), HEXB(1), LCT(15), MAN2C1(6), MANBA(6), NEU2(1), NEU3(1)	3666155	37	22	37	12	15	12	1	8	1	0	0.904	1.000
526	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), ESRRA(2), HDAC5(1), MEF2A(3), MEF2C(7), MEF2D(1), PPARA(1), PPP3CA(1), PPP3CB(4), PPP3CC(3), SLC2A4(3), SYT1(1)	4466644	40	22	40	22	16	9	2	8	5	0	0.905	1.000
527	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(5), POLA2(2), POLB(1), POLD1(5), POLD2(1), POLD3(2), POLE(17), POLE3(1), POLG(4), POLG2(1), POLH(4), POLI(7), POLK(2), POLM(1), POLQ(8), PRIM2(6), REV1(4), REV3L(15), RFC5(2)	9226370	88	34	86	25	23	24	0	30	10	1	0.906	1.000
528	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(4), DUSP1(2), IKBKAP(2), IKBKB(2), MAP3K1(6), MAP3K14(2), NFKB1(3), RELA(2), TNFAIP3(2), TRAF3(4), TRAF6(4)	3976714	33	20	33	13	17	3	0	8	5	0	0.908	1.000
529	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST2(1), HS3ST3B1(2), XYLT1(4), XYLT2(2)	1413911	10	9	10	12	4	1	1	3	1	0	0.908	1.000
530	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST2(1), HS3ST3B1(2), XYLT1(4), XYLT2(2)	1413911	10	9	10	12	4	1	1	3	1	0	0.908	1.000
531	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(1), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(1), AMDHD1(4), AOC2(4), AOC3(4), ASPA(3), CARM1(2), CNDP1(3), DDC(1), FTCD(2), HAL(3), HARS(2), HARS2(2), HDC(3), HNMT(4), LCMT1(1), LCMT2(2), MAOA(2), METTL2B(1), METTL6(5), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), PRPS2(2), UROC1(1), WBSCR22(1)	8678763	86	37	86	30	32	26	0	23	5	0	0.909	1.000
532	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(2), NDUFA4(1), NDUFB2(1), NDUFB6(1), NDUFS1(4), NDUFV1(2)	1567225	12	10	12	4	4	3	0	4	1	0	0.911	1.000
533	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS1(1), PAPSS2(2), SULT1A2(1), SULT1E1(1), SULT2A1(1), SUOX(2)	1367733	9	7	9	1	5	0	0	1	3	0	0.914	1.000
534	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(4), MBTPS1(5), SCAP(1), SREBF1(1), SREBF2(2)	2711560	14	13	14	10	4	6	1	0	3	0	0.915	1.000
535	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(4), PRKCA(2), PTK2B(1)	1526248	9	8	9	3	4	1	1	2	1	0	0.916	1.000
536	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(4), IL13(1), IL4(3), MAF(1), MAP2K3(2), MAPK14(3), NFATC1(1), NFATC2(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2)	2630285	25	18	25	7	15	2	2	4	2	0	0.917	1.000
537	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(5), C9orf95(1), CD38(1), ENPP1(4), ENPP3(3), NADK(1), NADSYN1(2), NMNAT1(1), NMNAT2(1), NMNAT3(2), NNMT(1), NNT(1), NT5C1A(1), NT5C1B(9), NT5C2(3), NT5C3(2), NT5E(2), NT5M(1), NUDT12(2), QPRT(1)	4949432	44	26	44	17	15	15	0	9	5	0	0.918	1.000
538	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), ADRBK2(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CLCA1(4), CLCA2(4), CLCA4(5), CNGA3(5), CNGA4(5), CNGB1(7), GNAL(3), GUCA1A(1), GUCA1B(2), PDC(2), PDE1C(7), PRKACB(1), PRKACG(2), PRKG1(4), PRKG2(3), PRKX(2)	6875932	66	29	65	30	22	14	2	20	8	0	0.923	1.000
539	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(6), GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(3), HDAC3(2), NCOA1(6), NCOA2(4), NCOA3(6), NCOR2(2), POLR2A(6), RXRA(1), TBP(1)	5500768	45	26	45	17	15	15	2	11	2	0	0.924	1.000
540	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(1), ANKRD1(4), ATF3(1), CYR61(2), HBEGF(1), IFNG(1), IFRD1(2), IL1A(1), IL1R1(3), NR4A3(2), WDR1(3)	2390028	21	13	21	5	5	9	0	5	2	0	0.924	1.000
541	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	3448610	29	19	28	8	11	11	1	3	3	0	0.925	1.000
542	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	3448610	29	19	28	8	11	11	1	3	3	0	0.925	1.000
543	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	3448610	29	19	28	8	11	11	1	3	3	0	0.925	1.000
544	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(6), CREBBP(21), CTBP1(1), CTBP2(2), DLL1(1), DLL3(2), DLL4(1), DTX1(4), DTX2(3), DTX3L(3), DTX4(3), DVL2(8), DVL3(2), EP300(13), HDAC1(2), HDAC2(2), HES1(1), JAG1(7), MAML1(1), MAML2(3), MAML3(1), NCOR2(2), NCSTN(5), NOTCH2(11), NOTCH3(12), NOTCH4(3), NUMB(2), NUMBL(3), PSEN1(3), PSEN2(2), PTCRA(1), RBPJ(1), RBPJL(3), SNW1(4)	15056595	139	51	138	54	48	42	1	27	21	0	0.929	1.000
545	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(5), ARSD(3), ARSE(2), ASAH1(3), GALC(1), GLA(4), GLB1(3), LCT(15), NEU2(1), NEU3(1), PPAP2B(1), SMPD1(6), SPTLC1(4), SPTLC2(2), UGCG(2)	5281950	54	25	54	17	19	14	2	16	3	0	0.930	1.000
546	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), IL22(2), IL22RA1(1), JAK1(3), JAK2(6), JAK3(6), STAT1(6), STAT3(2), STAT5B(2), TYK2(1)	4123712	30	20	29	14	12	6	2	7	2	1	0.931	1.000
547	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(2), CYP11B2(5), CYP17A1(2), HSD11B1(1), HSD3B1(2)	1499829	13	9	13	6	6	3	0	4	0	0	0.932	1.000
548	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(2), BLVRB(1), CP(3), EPRS(10), FECH(2), GUSB(2), HCCS(1), HMBS(2), HMOX1(2), HMOX2(1), PPOX(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2B15(2), UGT2B4(2), UROS(1)	5872591	49	26	48	16	17	12	0	15	5	0	0.936	1.000
549	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(3), ABO(2), B3GALNT1(3), B3GALT1(1), B3GALT2(3), B3GALT4(1), B3GALT5(2), B3GNT1(2), B3GNT2(1), B3GNT4(1), B3GNT5(1), B4GALNT1(3), B4GALT1(5), B4GALT2(3), B4GALT3(6), B4GALT6(5), FUT1(1), FUT2(1), FUT3(3), FUT6(1), FUT9(4), GCNT2(9), PIGA(1), PIGB(1), PIGG(1), PIGK(3), PIGM(1), PIGN(1), PIGO(2), PIGQ(1), PIGS(2), PIGT(2), PIGX(2), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2), ST3GAL6(4), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC5(4), ST6GALNAC6(3), ST8SIA1(3), ST8SIA5(4), UGCG(2)	10749110	110	40	110	30	45	21	4	23	17	0	0.938	1.000
550	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(8), ABCC2(11), ABCG2(5), BCHE(7), CES1(4), CES2(1), CYP3A4(1), CYP3A5(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5)	5140080	55	23	55	18	21	11	0	16	7	0	0.939	1.000
551	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(1), ACY1(2), ADC(1), ALDH18A1(5), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), AOC2(4), AOC3(4), ARG1(1), ARG2(4), ASS1(1), CPS1(8), GATM(1), MAOA(2), ODC1(2), OTC(4), SAT1(4), SAT2(1), SMS(2)	6651692	67	31	65	23	21	21	0	17	8	0	0.942	1.000
552	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(3), CD3D(1), CD3G(2), CD4(2), IFNG(1), IL12B(2), IL12RB1(2), IL12RB2(5), JAK2(6), TYK2(1)	3225578	26	15	27	17	5	10	1	6	3	1	0.942	1.000
553	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(5), ALDOC(1), FBP2(2), G6PD(2), GPI(1), H6PD(3), PFKM(1), PFKP(2), PGD(1), PGM1(2), PGM3(4), PRPS1L1(1), PRPS2(2), RPE(2), RPIA(3), TALDO1(3), TKT(3)	4495812	39	26	39	14	15	8	0	15	1	0	0.942	1.000
554	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(1), CA1(1), CA14(2), CA2(1), CA3(1), CA4(1), CA5A(1), CA6(2), CA8(2), CA9(2), CPS1(8), CTH(1), GLS2(2), GLUD1(2), GLUL(3), HAL(3)	4253878	33	20	33	18	13	9	0	5	6	0	0.943	1.000
555	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(5), ARG1(1), ARG2(4), CKM(4), CKMT1B(1), CKMT2(2), CPS1(8), GAMT(1), GATM(1), GLUD1(2), ODC1(2), OTC(4), SMS(2)	3891102	39	21	39	14	11	12	0	9	7	0	0.945	1.000
556	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(5), ACAA1(2), ACADM(3), ACAT1(1), ACAT2(2), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(3), ALDH7A1(1), ALDH9A1(1), AOX1(5), AUH(1), BCAT1(1), BCAT2(1), BCKDHA(3), BCKDHB(1), ECHS1(2), EHHADH(2), HADH(1), HADHA(2), HADHB(1), HMGCS1(1), HSD17B10(1), HSD17B4(3), MCCC1(7), MCCC2(2), MCEE(1), MUT(3), OXCT1(3), OXCT2(1), PCCA(3), PCCB(3)	9836332	84	38	84	23	35	19	0	21	9	0	0.947	1.000
557	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(4), IFNA1(1), IFNB1(1), IKBKB(2), IL1A(1), IL1R1(3), IL1RN(2), IL6(1), IRAK1(1), IRAK2(8), IRAK3(1), MAP2K3(2), MAP2K6(2), MAP3K1(6), MAP3K14(2), MAP3K7(2), MAPK14(3), MAPK8(2), MYD88(1), NFKB1(3), RELA(2), TGFB1(1), TGFB2(5), TOLLIP(1), TRAF6(4)	6521723	61	27	61	18	26	9	1	18	7	0	0.950	1.000
558	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	CHUK(4), IFNG(1), IKBKB(2), IL2(3), IL4(3), MAP3K1(6), MAP3K5(5), MAP4K5(2), MAPK14(3), MAPK8(2), NFKB1(3), RELA(2), TNFRSF9(2), TRAF2(1)	4337863	39	20	39	11	17	8	1	11	2	0	0.951	1.000
559	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(3), ARSE(2), ASAH1(3), B4GALT6(5), CERK(1), DEGS1(1), ENPP7(1), GALC(1), GLA(4), GLB1(3), LCT(15), NEU2(1), NEU3(1), PPAP2B(1), SGMS1(2), SGMS2(4), SGPP2(2), SMPD1(6), SMPD3(3), SMPD4(1), SPHK2(1), SPTLC1(4), SPTLC2(2), UGCG(2), UGT8(6)	7755348	76	34	75	26	25	23	2	21	5	0	0.951	1.000
560	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), FDXR(1), SHMT1(1)	3646018	30	19	29	9	11	11	1	4	3	0	0.953	1.000
561	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(6), DLL1(1), FURIN(2), PSEN1(3)	2035925	12	10	12	2	5	4	0	0	3	0	0.959	1.000
562	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), CAPN1(2), CAPN10(3), CAPN11(1), CAPN2(5), CAPN3(6), CAPN5(5), CAPN6(2), CAPN7(3), CAPN9(1), CAPNS1(1), CAV2(1), CAV3(2), CSK(1), DOCK1(5), FYN(4), GIT2(6), GRB2(2), ITGA10(3), ITGA11(2), ITGA2(5), ITGA2B(2), ITGA3(4), ITGA4(3), ITGA5(7), ITGA6(3), ITGA7(6), ITGA8(5), ITGA9(4), ITGAD(7), ITGAE(5), ITGAL(5), ITGAM(5), ITGAV(1), ITGAX(4), ITGB1(6), ITGB2(4), ITGB3(7), ITGB4(2), ITGB5(5), ITGB6(6), ITGB7(4), ITGB8(4), MAP2K1(3), MAP2K3(2), MAP2K6(2), MAPK10(4), MAPK12(2), MAPK4(1), MAPK6(2), MAPK7(3), MYLK2(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PDPK1(1), PIK3R2(1), PTK2(5), RAP1B(2), RAPGEF1(4), RHO(2), ROCK1(8), ROCK2(2), SHC1(3), SHC3(1), SORBS1(7), SOS1(5), SRC(3), TLN1(5), TNS1(11), VASP(3), VAV2(2), VAV3(10), VCL(1)	29475050	268	71	264	105	97	50	7	83	31	0	0.960	1.000
563	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(4), EGR2(6), EGR3(2), GNAQ(3), MAP3K1(6), NFATC1(1), NFATC2(3), NFKB1(3), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), RELA(2), SYT1(1), VIPR2(3)	6108680	53	29	52	16	25	9	2	8	9	0	0.962	1.000
564	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), ARG1(1), GLUD1(2)	1206787	5	5	5	2	3	2	0	0	0	0	0.962	1.000
565	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(14), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(5), ADIPOQ(4), ADIPOR1(1), ADIPOR2(2), AKT1(2), AKT2(5), CAMKK1(1), CAMKK2(1), CD36(1), CHUK(4), CPT1A(5), CPT1B(5), CPT2(1), G6PC(3), IKBKB(2), IRS1(5), IRS4(11), JAK1(3), JAK2(6), JAK3(6), LEP(1), LEPR(5), MAPK10(4), MAPK8(2), MAPK9(3), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), NPY(1), PCK2(3), POMC(2), PPARA(1), PPARGC1A(5), PRKAA1(2), PRKAA2(6), PRKAB1(1), PRKAB2(1), PRKAG1(1), PRKAG2(2), PRKAG3(4), PRKCQ(4), PTPN11(2), RELA(2), RXRA(1), RXRB(2), RXRG(3), SLC2A4(3), STAT3(2), TNFRSF1A(1), TRADD(1), TRAF2(1), TYK2(1)	18673754	179	55	178	65	55	48	4	54	17	1	0.963	1.000
566	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(2), AASS(7), ACAT1(1), ACAT2(2), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), BBOX1(1), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(2), EHMT2(1), GCDH(3), HADH(1), HADHA(2), HSD17B10(1), HSD17B4(3), HSD3B7(2), NSD1(11), OGDH(4), OGDHL(8), PIPOX(4), PLOD1(3), PLOD2(4), PLOD3(3), RDH12(2), RDH13(1), SETD1A(7), SETD7(2), SETDB1(7), SHMT1(1), SHMT2(2), SPCS1(1), SUV39H1(1), SUV39H2(2), TMLHE(1)	13066752	120	46	120	33	50	22	0	32	16	0	0.964	1.000
567	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	BRAF(21), CHUK(4), CREB1(1), GRB2(2), IKBKB(2), MAP2K1(3), MAP2K3(2), MAP2K4(9), MAP2K5(2), MAP2K6(2), MAP3K1(6), MAP3K10(2), MAP3K11(4), MAP3K12(4), MAP3K13(8), MAP3K14(2), MAP3K2(2), MAP3K3(2), MAP3K4(15), MAP3K5(5), MAP3K6(6), MAP3K7(2), MAP3K8(2), MAP3K9(2), MAP4K1(2), MAP4K3(3), MAP4K4(5), MAP4K5(2), MAPK1(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK3(2), MAPK4(1), MAPK6(2), MAPK7(3), MAPK8(2), MAPK9(3), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(1), MAX(1), MEF2A(3), MEF2C(7), MEF2D(1), MKNK1(1), MKNK2(2), NFKB1(3), PAK1(4), PAK2(2), RAF1(4), RELA(2), RIPK1(2), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KA5(3), RPS6KB1(3), RPS6KB2(1), SHC1(3), SP1(2), STAT1(6), TGFB1(1), TGFB2(5), TGFBR1(6), TRADD(1), TRAF2(1)	21122302	227	57	204	60	76	47	6	74	24	0	0.964	1.000
568	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(5), POLD2(1), POLE(17), POLG(4), POLQ(8)	3767056	36	19	34	9	15	6	0	12	3	0	0.964	1.000
569	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(6), GNA12(2), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAR2B(2)	2305248	14	11	14	10	4	3	0	2	5	0	0.965	1.000
570	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(1), ARFGAP3(3), ARFGEF2(5), CLTA(1), COPA(1), GBF1(11), GPLD1(4), KDELR1(2), KDELR3(1)	3720912	29	20	29	12	12	7	0	8	2	0	0.966	1.000
571	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ARG1(1), ARG2(4), ASS1(1), CKM(4), CKMT1B(1), CKMT2(2), CPS1(8), DAO(2), EPRS(10), GAMT(1), GATM(1), GLUD1(2), GLUD2(4), GOT1(5), GOT2(1), LAP3(1), NOS1(5), NOS3(2), OTC(4), P4HA2(2), P4HA3(1), RARS(2), RARS2(3)	8004672	69	31	69	25	22	19	0	17	11	0	0.966	1.000
572	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(13), ATP4A(8), ATP4B(1), ATP5A1(2), ATP5B(4), ATP5C1(2), ATP5D(1), ATP5F1(1), ATP5G3(1), ATP5J2(1), ATP5O(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V0D2(6), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), COX10(2), COX15(1), COX17(1), COX4I1(2), COX4I2(2), COX6A2(1), COX6C(1), COX7A1(1), COX7B2(1), COX8C(1), CYC1(1), LHPP(1), NDUFA1(1), NDUFA10(2), NDUFA12(2), NDUFA13(1), NDUFA4(1), NDUFA9(2), NDUFB1(1), NDUFB2(1), NDUFB3(1), NDUFB6(1), NDUFB9(1), NDUFC2(1), NDUFS1(4), NDUFS3(2), NDUFS6(2), NDUFV1(2), PPA1(2), PPA2(1), SDHA(5), SDHB(2), SDHD(1), TCIRG1(2), UQCRB(2), UQCRC1(2), UQCRC2(2), UQCRFS1(1), UQCRH(1)	12651670	133	44	132	32	55	36	1	29	12	0	0.969	1.000
573	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(5), CD38(1), ENPP1(4), ENPP3(3), NADSYN1(2), NMNAT1(1), NMNAT2(1), NNMT(1), NNT(1), NT5E(2), NT5M(1), QPRT(1)	3362885	23	16	23	11	9	8	0	4	2	0	0.970	1.000
574	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(17), ASH2L(2), C17orf79(1), CARM1(2), CTCFL(7), DOT1L(3), EED(2), EHMT1(2), EHMT2(1), EZH1(4), EZH2(4), FBXO11(4), JMJD6(2), KDM6A(1), MEN1(1), MLL(15), MLL2(14), MLL3(10), MLL4(8), MLL5(11), NSD1(11), OGT(4), PAXIP1(5), PPP1CB(1), PPP1CC(1), PRDM2(13), PRDM7(1), PRDM9(13), PRMT1(1), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), RBBP5(2), SATB1(1), SETD1A(7), SETD2(10), SETD7(2), SETD8(2), SETDB1(7), SETDB2(1), SMYD3(2), STK38(1), SUV39H1(1), SUV39H2(2), SUV420H1(5), SUZ12(2), WHSC1(6), WHSC1L1(4)	25970639	223	59	220	73	89	42	2	60	28	2	0.972	1.000
575	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	CREB1(1), KEAP1(3), MAPK1(2), MAPK14(3), MAPK8(2), NFE2L2(1), PRKCA(2)	1909327	14	9	14	3	2	5	0	7	0	0	0.973	1.000
576	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	AGPAT1(1), AGPAT3(3), AGPAT4(6), AGPAT6(1), CDS1(1), CDS2(4), CHAT(6), CHKA(2), DGKA(1), DGKB(7), DGKD(9), DGKE(1), DGKG(3), DGKH(5), DGKI(6), DGKZ(2), ESCO1(7), ESCO2(3), ETNK1(2), ETNK2(1), GNPAT(1), GPAM(2), GPD1(1), GPD1L(2), GPD2(3), LCAT(1), MYST3(13), MYST4(5), PCYT1A(4), PCYT1B(5), PEMT(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PLD1(8), PLD2(1), PNPLA3(4), PPAP2B(1), PTDSS1(4), SH3GLB1(3)	14992014	139	47	138	56	50	38	1	40	10	0	0.974	1.000
577	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(3), AASDHPPT(2), AASS(7), ACAT1(1), ACAT2(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), BBOX1(1), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(2), EHMT2(1), GCDH(3), HADHA(2), PLOD1(3), PLOD2(4), PLOD3(3), SDS(2), SHMT1(1), SHMT2(2), TMLHE(1)	8307032	76	34	76	17	29	17	0	20	10	0	0.974	1.000
578	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(1), HSD3B7(2), RDH12(2), RDH13(1)	1067763	6	5	6	3	3	1	0	2	0	0	0.975	1.000
579	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(5), ALDOC(1), DERA(1), FBP2(2), G6PD(2), GPI(1), H6PD(3), PFKL(1), PFKM(1), PFKP(2), PGD(1), PGM1(2), PGM3(4), PRPS1L1(1), PRPS2(2), RPE(2), RPIA(3), TALDO1(3), TKT(3), TKTL1(4), TKTL2(5)	5372056	50	28	50	16	20	12	0	16	2	0	0.976	1.000
580	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(4), IKBKB(2), IL1A(1), IL1R1(3), IRAK1(1), MAP3K1(6), MAP3K14(2), MAP3K7(2), MYD88(1), NFKB1(3), RELA(2), RIPK1(2), TLR4(7), TNFAIP3(2), TNFRSF1A(1), TRADD(1), TRAF6(4)	5376907	44	21	44	15	18	7	2	12	5	0	0.977	1.000
581	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), ACAT2(2), BDH1(1), HMGCS1(1), OXCT1(3), OXCT2(1)	1654560	9	8	9	3	4	1	0	4	0	0	0.978	1.000
582	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(8), AMY2A(3), ASCC3(14), ATP13A2(3), DDX18(2), DDX19A(2), DDX23(4), DDX4(2), DDX41(2), DDX47(3), DDX50(2), DDX52(1), DDX54(5), DDX55(2), DDX56(3), DHX58(2), ENPP1(4), ENPP3(3), ENTPD7(4), EP400(18), ERCC2(4), ERCC3(6), G6PC(3), GANC(2), GBA3(3), GBE1(4), GCK(1), GPI(1), GUSB(2), GYS1(1), GYS2(8), HK1(6), HK2(3), HK3(4), IFIH1(5), MGAM(9), MOV10L1(6), PGM1(2), PGM3(4), PYGB(4), PYGL(2), PYGM(2), RAD54B(6), RAD54L(3), RUVBL2(1), SETX(11), SI(12), SKIV2L2(2), SMARCA2(8), SMARCA5(3), TREH(2), UGDH(3), UGP2(5), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2A1(8), UGT2A3(5), UGT2B10(1), UGT2B11(4), UGT2B15(2), UGT2B17(4), UGT2B28(2), UGT2B4(2), UGT2B7(4), UXS1(6)	26917431	278	64	274	85	96	76	3	69	33	1	0.978	1.000
583	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(14), ACACB(14), FASN(1), MCAT(1), OLAH(1), OXSM(4)	3645065	35	18	35	8	13	10	0	10	2	0	0.978	1.000
584	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(2), CHST12(2), CHST13(1), PAPSS1(1), PAPSS2(2), SULT1A1(2), SULT1A2(1), SULT1E1(1), SULT2A1(1), SULT2B1(1), SUOX(2)	2068896	17	11	17	3	9	2	0	3	3	0	0.979	1.000
585	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(4), DUSP1(2), IKBKAP(2), IKBKB(2), MAP3K1(6), MAP3K14(2), NFKB1(3), RELA(2), RIPK1(2), TANK(3), TNFAIP3(2), TRAF1(1), TRAF2(1), TRAF3(4)	4932283	36	21	36	13	19	6	0	7	4	0	0.980	1.000
586	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(3), FUCA1(1), GLB1(3), HEXB(1), LCT(15), MAN2B1(4), MAN2B2(1), MAN2C1(6), MANBA(6), NEU2(1), NEU3(1)	4503008	42	23	42	15	15	14	1	11	1	0	0.982	1.000
587	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(7), CLOCK(5), CRY1(2), CRY2(1), PER1(1)	1928382	16	10	16	4	7	2	0	5	2	0	0.982	1.000
588	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDFT1(2), HMGCR(2), IDI1(1), LSS(1), MVK(1), NQO1(1), PMVK(1), SC5DL(1), SQLE(1)	2478269	13	12	13	6	7	4	0	1	1	0	0.983	1.000
589	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(4), CDC40(3), CLK3(2), CLK4(2), COL2A1(8), CPSF1(4), CPSF2(1), CPSF3(1), CPSF4(3), CSTF1(1), CSTF2T(5), CSTF3(2), DDX1(4), DDX20(3), DHX15(1), DHX16(6), DHX38(10), DHX8(6), DHX9(4), DICER1(7), DNAJC8(2), METTL3(3), NCBP1(4), NCBP2(1), NONO(1), NUDT21(1), NXF1(5), PABPN1(1), PAPOLA(2), PHF5A(1), POLR2A(6), PPM1G(1), PRPF18(3), PRPF3(1), PRPF4(4), PRPF4B(3), PRPF8(9), PSKH1(1), PTBP1(1), PTBP2(3), RBM17(2), RBM5(1), RNGTT(6), RNMT(3), SF3A1(2), SF3A2(1), SF3A3(1), SF3B1(9), SF3B2(2), SF3B4(4), SFRS14(2), SFRS4(2), SNRPB2(1), SNRPE(2), SNRPN(2), SNURF(1), SPOP(2), SRPK1(7), SRPK2(2), SRRM1(8), SUPT5H(10), TXNL4A(1), U2AF1(1), U2AF2(2), XRN2(6)	23732676	210	63	210	60	69	53	3	51	34	0	0.985	1.000
590	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(7), AP2A1(2), AP2M1(4), BIN1(1), DNM1(8), EPN1(1), EPS15(4), PICALM(2), PPP3CA(1), PPP3CB(4), PPP3CC(3), SYNJ1(8), SYNJ2(5), SYT1(1)	4961899	51	22	49	22	14	11	1	13	12	0	0.986	1.000
591	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	RPL10A(1), RPL10L(2), RPL18A(1), RPL21(1), RPL22L1(1), RPL24(1), RPL28(1), RPL3(2), RPL31(2), RPL32(1), RPL35(1), RPL39(1), RPL3L(1), RPL6(1), RPL7(1), RPL9(3), RPS11(1), RPS13(1), RPS16(1), RPS18(1), RPS20(1), RPS23(4), RPS3(1), RPS9(2), RPSA(1)	4720501	34	21	34	10	14	7	0	10	3	0	0.986	1.000
592	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(1), CAD(10), CDA(1), CTPS(3), CTPS2(4), DCK(1), DCTD(3), DHODH(3), DPYD(8), DPYS(6), ENTPD1(2), ITPA(2), NT5E(2), NT5M(1), POLB(1), POLD1(5), POLD2(1), POLE(17), POLG(4), POLQ(8), POLR1B(6), POLR2A(6), POLR2B(5), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLRMT(1), RRM1(1), RRM2(2), TK1(1), TXNRD1(2), TYMS(2), UCK2(1), UNG(1), UPB1(3)	12889515	118	42	116	30	36	34	3	36	9	0	0.987	1.000
593	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(3), ARSB(5), FUCA1(1), GALNS(4), GLB1(3), GNS(1), GUSB(2), HEXB(1), HGSNAT(6), HPSE(2), HPSE2(9), IDS(2), IDUA(1), LCT(15), MAN2B1(4), MAN2B2(1), MAN2C1(6), MANBA(6), NAGLU(3), NEU2(1), NEU3(1), SPAM1(1)	7626724	78	31	77	26	27	18	2	23	8	0	0.988	1.000
594	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(1), EEF1G(1), EEF2(3), EIF2AK1(5), EIF2AK3(1), EIF2B1(2), EIF2B3(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), EIF4A2(4), EIF4G1(8), EIF4G3(8), EIF5(3), EIF5A(1), EIF5B(4), ETF1(2), KIAA0664(4), PABPC1(3), PABPC3(4), PAIP1(1), SLC35A4(2)	9672283	66	34	65	19	21	15	2	18	10	0	0.990	1.000
595	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(5), ALDOC(1), DLAT(2), ENO2(3), ENO3(3), FBP2(2), G6PC(3), GCK(1), GOT1(5), GOT2(1), GPI(1), HK1(6), HK2(3), HK3(4), LDHA(1), LDHAL6B(1), LDHB(1), LDHC(2), MDH1(1), MDH2(1), PC(3), PDHA1(4), PDHA2(6), PDHB(2), PDHX(2), PFKL(1), PFKM(1), PFKP(2), PGAM1(3), PGAM2(1), PGK1(3), PGK2(6), PKM2(2), TNFAIP1(3), TPI1(1)	9359869	88	36	87	30	38	17	1	25	7	0	0.990	1.000
596	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), CYP51A1(3), DHCR24(2), DHCR7(2), EBP(2), FDFT1(2), GGCX(2), HMGCR(2), IDI1(1), IDI2(1), LSS(1), MVK(1), NQO1(1), NSDHL(2), PMVK(1), SC5DL(1), SQLE(1)	4305366	28	19	28	9	10	7	1	6	4	0	0.990	1.000
597	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(1), AGXT2(5), ALAS1(5), ALAS2(5), AOC2(4), AOC3(4), BHMT(3), CBS(2), CHDH(1), CHKA(2), CPT1B(5), CTH(1), DAO(2), DMGDH(5), GAMT(1), GARS(3), GATM(1), GLDC(2), MAOA(2), PEMT(1), PLCB2(3), PLCG1(4), PLCG2(9), SARDH(7), SARS(1), SHMT1(1), SHMT2(2), TARS(3)	9396084	85	36	84	30	38	22	0	14	11	0	0.991	1.000
598	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), B4GALT1(5), B4GALT2(3), G6PC(3), GALE(1), GALK2(2), GALT(2), GANC(2), GCK(1), GLA(4), GLB1(3), HK1(6), HK2(3), HK3(4), HSD3B7(2), LCT(15), MGAM(9), PFKL(1), PFKM(1), PFKP(2), PGM1(2), PGM3(4), RDH12(2), RDH13(1), UGP2(5)	8464403	85	33	85	31	39	23	1	19	3	0	0.991	1.000
599	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(2), SEC61A2(1), SRP19(1), SRP54(1), SRP68(1), SRP72(3)	1699033	9	8	9	4	4	2	0	3	0	0	0.991	1.000
600	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(3), DDX20(3), E2F4(1), ETS2(2), HDAC2(2), HDAC5(1), NCOR2(2), RBL1(3), RBL2(8), SIN3A(4), SIN3B(3)	5863448	33	20	33	18	10	6	0	9	8	0	0.991	1.000
601	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	AGPAT1(1), AGPAT3(3), AGPAT4(6), AGPS(2), CDS1(1), CDS2(4), CHAT(6), CHKA(2), CLC(2), CPT1B(5), DGKA(1), DGKB(7), DGKD(9), DGKE(1), DGKG(3), DGKH(5), DGKZ(2), ETNK1(2), GNPAT(1), GPD1(1), GPD2(3), LCAT(1), PAFAH1B1(3), PCYT1A(4), PCYT1B(5), PEMT(1), PLA2G1B(1), PLA2G4A(5), PLA2G6(2), PLCB2(3), PLCG1(4), PLCG2(9), PPAP2B(1)	11282175	106	40	104	41	40	25	1	29	11	0	0.992	1.000
602	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(1), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH4A1(2), ALDH9A1(1), AOC2(4), AOC3(4), ARG1(1), ARG2(4), CKM(4), CKMT1B(1), CKMT2(2), CPS1(8), DAO(2), GAMT(1), GATM(1), GLUD1(2), GOT1(5), GOT2(1), MAOA(2), NOS1(5), NOS3(2), ODC1(2), OTC(4), P4HA2(2), P4HA3(1), P4HB(2), RARS(2), SMS(2)	9781881	95	35	95	32	36	27	0	22	10	0	0.992	1.000
603	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(3), DHCR7(2), FDFT1(2), HMGCR(2), HMGCS1(1), IDI1(1), LSS(1), MVK(1), NSDHL(2), PMVK(1), SC5DL(1), SQLE(1)	2946365	18	13	18	7	8	5	0	3	2	0	0.992	1.000
604	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	17	B3GAT1(1), CHPF(3), CHST11(2), CHST12(2), CHST13(1), CHST14(1), CHSY1(5), DSE(2), UST(1), XYLT1(4), XYLT2(2)	3125802	24	15	24	21	8	7	2	5	2	0	0.993	1.000
605	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC7(2), CDK2(2), DIAPH2(9), GMNN(1), MCM10(6), MCM3(1), MCM4(4), MCM5(3), MCM6(3), MCM7(2), NACA(5), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(17), RFC1(10), RFC4(3), RFC5(2), RPA1(2), RPA2(1), RPA4(2), UBA52(2), UBB(1)	11275109	94	37	93	21	22	23	0	36	13	0	0.993	1.000
606	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(6), POLR2A(6), POLR2B(5), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLRMT(1)	3030829	22	12	22	3	7	8	1	5	1	0	0.993	1.000
607	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), MST1(1), MST1R(1)	1358366	3	3	3	1	1	1	0	1	0	0	0.995	1.000
608	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), F13B(3), HSD17B2(1), HSD17B3(1), HSD17B4(3), HSD3B1(2)	1844290	12	8	12	2	4	4	0	3	1	0	0.995	1.000
609	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), ALDOA(1), ALDOB(5), ALDOC(1), FBP2(2), FPGT(3), FUK(1), GMDS(1), GMPPA(6), HK1(6), HK2(3), HK3(4), HSD3B7(2), KHK(1), LHPP(1), MPI(1), MTMR1(4), MTMR2(1), MTMR6(4), PFKFB1(6), PFKFB4(2), PFKL(1), PFKM(1), PFKP(2), PHPT1(1), PMM1(1), RDH12(2), RDH13(1), TPI1(1), TSTA3(1)	8400861	68	33	68	32	27	14	0	22	5	0	0.996	1.000
610	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(1), ALPP(1), GGH(1)	1353847	5	5	5	1	2	1	1	1	0	0	0.996	1.000
611	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	APAF1(7), ARHGDIB(3), BAG4(2), BCL2(1), BID(1), BIRC2(2), BIRC3(2), CASP2(4), CASP3(1), CASP6(1), CASP7(1), CASP8(11), CASP9(2), CFLAR(2), CHUK(4), CRADD(1), DFFA(2), DFFB(2), LMNB1(2), LMNB2(1), MAP3K1(6), MAP3K14(2), MAP3K5(5), MAPK8(2), MDM2(4), NFKB1(3), NUMA1(8), PAK2(2), PRKCD(3), PRKDC(13), PSEN1(3), PSEN2(2), PTK2(5), RASA1(5), RB1(4), RELA(2), RIPK1(2), SPTAN1(9), TNFRSF1A(1), TRADD(1), TRAF1(1), TRAF2(1)	15078184	136	43	135	44	41	36	6	35	16	2	0.996	1.000
612	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(1), AGXT2(5), ALAS1(5), ALAS2(5), AOC2(4), AOC3(4), BHMT(3), CBS(2), CHDH(1), CHKA(2), CTH(1), DAO(2), DMGDH(5), GAMT(1), GARS(3), GATM(1), GLDC(2), GNMT(1), HSD3B7(2), MAOA(2), PEMT(1), PHGDH(2), PIPOX(4), PSAT1(3), RDH12(2), RDH13(1), SARDH(7), SARS(1), SARS2(2), SDS(2), SHMT1(1), SHMT2(2), TARS(3), TARS2(4)	9632105	87	35	87	31	35	22	0	19	11	0	0.997	1.000
613	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(1), ALPP(1), ASCC3(14), ATP13A2(3), DDX18(2), DDX19A(2), DDX23(4), DDX4(2), DDX41(2), DDX47(3), DDX50(2), DDX52(1), DDX54(5), DDX55(2), DDX56(3), DHX58(2), ENTPD7(4), EP400(18), ERCC2(4), ERCC3(6), GGH(1), IFIH1(5), MOV10L1(6), RAD54B(6), RAD54L(3), RUVBL2(1), SETX(11), SKIV2L2(2), SMARCA2(8), SMARCA5(3)	14115773	129	40	126	38	54	35	3	24	12	1	0.997	1.000
614	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(7), AZIN1(2), BTG1(1), CBX3(1), CLOCK(5), CRY1(2), CRY2(1), DNAJA1(1), EIF4G2(7), ETV6(4), GFRA1(3), GSTM3(2), HERPUD1(1), HSPA8(3), IDI1(1), MYF6(1), NCKAP1(8), NCOA4(3), NR1D2(3), PER1(1), PER2(2), PPP1R3C(2), PSMA4(2), SF3A3(1), SUMO3(1), TUBB3(1), UCP3(2), UGP2(5), ZFR(1)	8255610	74	29	72	17	33	14	3	16	8	0	0.997	1.000
615	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(3), GPLD1(4), PGAP1(6), PIGA(1), PIGB(1), PIGG(1), PIGK(3), PIGM(1), PIGN(1), PIGO(2), PIGQ(1), PIGS(2), PIGT(2), PIGW(1), PIGX(2)	5321874	31	18	31	13	10	6	1	9	5	0	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		117141	0	0	0	1	0	0	0	0	0	0	1.000	1.000
