E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.019 0.028 -9999.0 0.0 -0.279 2.0 2.0 KLHL20 0.033 0.055 0.141 1.0 -0.213 3.0 4.0 CYFIP2 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.068 0.073 0.207 7.0 -9999.0 0.0 7.0 ENAH 0.019 0.028 -9999.0 0.0 -0.279 2.0 2.0 AP1M1 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.016 0.018 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.005 0.021 -9999.0 0.0 -0.159 2.0 2.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.03 -9999.0 0.0 -9999.0 0.0 0.0 RAPGEF1 0.056 0.079 0.286 2.0 -0.28 1.0 3.0 CTNND1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.026 0.029 -9999.0 0.0 -0.286 2.0 2.0 CRK 0.056 0.077 -9999.0 0.0 -0.298 1.0 1.0 E-cadherin/gamma catenin/alpha catenin 0.046 0.01 -9999.0 0.0 -9999.0 0.0 0.0 alphaE/beta7 Integrin 0.027 0.029 -9999.0 0.0 -0.154 5.0 5.0 IQGAP1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.044 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.019 0.028 -9999.0 0.0 -0.279 2.0 2.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.004 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.023 0.063 -9999.0 0.0 -0.24 7.0 7.0 PI3K 0.007 0.012 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.054 0.012 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.025 0.044 0.1 13.0 -9999.0 0.0 13.0 PIK3R1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.078 0.075 0.201 12.0 -9999.0 0.0 12.0 actin cytoskeleton organization 0.038 0.054 0.168 14.0 -0.156 3.0 17.0 CDC42/GDP 0.073 0.073 0.22 6.0 -9999.0 0.0 6.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.017 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ITGB7 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.058 0.013 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.041 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.071 0.081 0.193 21.0 -9999.0 0.0 21.0 CDC42/GTP/IQGAP1 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.086 0.073 0.195 25.0 -9999.0 0.0 25.0 RAC1/GTP/IQGAP1 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.035 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.03 0.043 0.127 14.0 -0.142 5.0 19.0 NME1 0.013 0.076 0.308 2.0 -0.4 7.0 9.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.018 0.028 -9999.0 0.0 -0.279 2.0 2.0 regulation of cell-cell adhesion 0.011 0.013 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.016 0.023 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.073 0.067 0.17 16.0 -9999.0 0.0 16.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.057 0.033 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 0.035 0.051 0.149 13.0 -0.173 5.0 18.0 VAV2 0.079 0.095 -9999.0 0.0 -0.5 2.0 2.0 RAP1/GDP 0.083 0.074 0.193 25.0 -9999.0 0.0 25.0 adherens junction assembly 0.018 0.027 -9999.0 0.0 -0.272 2.0 2.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.045 0.031 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin 0.012 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.012 0.024 -9999.0 0.0 -0.313 1.0 1.0 PIK3CA 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP 0.001 0.051 -9999.0 0.0 -0.34 3.0 3.0 E-cadherin/beta catenin/alpha catenin 0.047 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.02 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.026 0.03 -9999.0 0.0 -0.291 2.0 2.0