PLK1 signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations regulation of centriole-centriole cohesion 0.003 0.048 0.207 11.0 -9999.0 0.0 11.0 BUB1B -0.098 0.154 -9999.0 0.0 -0.377 45.0 45.0 PLK1 -0.015 0.042 -9999.0 0.0 -0.126 10.0 10.0 PLK1S1 -0.008 0.021 -9999.0 0.0 -0.092 1.0 1.0 KIF2A -0.002 0.038 -9999.0 0.0 -9999.0 0.0 0.0 regulation of mitotic centrosome separation -0.015 0.042 -9999.0 0.0 -0.126 10.0 10.0 GOLGA2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Hec1/SPC24 -0.015 0.051 -9999.0 0.0 -0.465 2.0 2.0 WEE1 -0.05 0.077 -9999.0 0.0 -0.335 3.0 3.0 cytokinesis -0.033 0.134 -9999.0 0.0 -0.378 27.0 27.0 PP2A-alpha B56 -0.102 0.129 -9999.0 0.0 -0.495 3.0 3.0 AURKA -0.02 0.061 -9999.0 0.0 -0.167 30.0 30.0 PICH/PLK1 -0.38 0.355 -9999.0 0.0 -0.725 95.0 95.0 CENPE -0.019 0.101 -9999.0 0.0 -0.477 9.0 9.0 RhoA/GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of microtubule depolymerization -0.001 0.038 -9999.0 0.0 -9999.0 0.0 0.0 PPP2CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FZR1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TPX2 -0.04 0.077 -9999.0 0.0 -0.168 57.0 57.0 PAK1 0.015 0.002 -9999.0 0.0 -9999.0 0.0 0.0 SPC24 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FBXW11 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CLSPN -0.005 0.038 -9999.0 0.0 -0.202 5.0 5.0 GORASP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 metaphase -0.001 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NLP -0.008 0.021 -9999.0 0.0 -0.092 1.0 1.0 G2 phase of mitotic cell cycle -0.003 0.004 -9999.0 0.0 -0.012 28.0 28.0 STAG2 -0.006 0.129 -9999.0 0.0 -0.722 7.0 7.0 GRASP65/GM130/RAB1/GTP -0.012 0.024 -9999.0 0.0 -9999.0 0.0 0.0 spindle elongation -0.015 0.042 -9999.0 0.0 -0.126 10.0 10.0 ODF2 0.01 0.049 -9999.0 0.0 -0.719 1.0 1.0 BUB1 -0.128 0.146 -9999.0 0.0 -0.557 3.0 3.0 TPT1 -0.0 0.021 -9999.0 0.0 -9999.0 0.0 0.0 CDC25C -0.011 0.058 -9999.0 0.0 -0.226 13.0 13.0 CDC25B -0.335 0.368 -9999.0 0.0 -0.723 105.0 105.0 SGOL1 -0.003 0.048 -9999.0 0.0 -0.207 11.0 11.0 RHOA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CCNB1/CDK1 -0.261 0.258 -9999.0 0.0 -0.524 82.0 82.0 CDC14B 0.013 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC20 -0.003 0.12 -9999.0 0.0 -0.722 6.0 6.0 PLK1/PBIP1 -0.05 0.127 -9999.0 0.0 -0.425 22.0 22.0 mitosis 0.002 0.012 0.033 30.0 -0.026 1.0 31.0 FBXO5 -0.04 0.088 -9999.0 0.0 -0.389 9.0 9.0 CDC2 -0.062 0.217 -9999.0 0.0 -0.734 21.0 21.0 NDC80 0.01 0.07 -9999.0 0.0 -0.722 2.0 2.0 metaphase plate congression -0.003 0.025 -9999.0 0.0 -9999.0 0.0 0.0 ERCC6L -0.383 0.332 -9999.0 0.0 -0.742 86.0 86.0 NLP/gamma Tubulin -0.004 0.022 -9999.0 0.0 -0.107 1.0 1.0 microtubule cytoskeleton organization -0.0 0.021 -9999.0 0.0 -9999.0 0.0 0.0 G2/M transition DNA damage checkpoint -0.002 0.002 -9999.0 0.0 -9999.0 0.0 0.0 PPP1R12A 0.016 0.001 -9999.0 0.0 -9999.0 0.0 0.0 interphase -0.002 0.002 -9999.0 0.0 -9999.0 0.0 0.0 PLK1/PRC1-2 -0.053 0.174 -9999.0 0.0 -0.466 31.0 31.0 GRASP65/GM130/RAB1/GTP/PLK1 -0.004 0.02 -9999.0 0.0 -9999.0 0.0 0.0 RAB1A 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 prophase 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Aurora A/BORA -0.01 0.054 -9999.0 0.0 -0.429 1.0 1.0 mitotic prometaphase -0.002 0.001 -9999.0 0.0 -9999.0 0.0 0.0 proteasomal ubiquitin-dependent protein catabolic process 0.016 0.027 -9999.0 0.0 -9999.0 0.0 0.0 microtubule-based process -0.055 0.158 -9999.0 0.0 -0.469 27.0 27.0 Golgi organization -0.015 0.042 -9999.0 0.0 -0.126 10.0 10.0 Cohesin/SA2 -0.027 0.073 -9999.0 0.0 -0.407 7.0 7.0 PPP1CB/MYPT1 0.0 0.002 -9999.0 0.0 -9999.0 0.0 0.0 KIF20A -0.073 0.242 -9999.0 0.0 -0.722 27.0 27.0 APC/C/CDC20 -0.014 0.085 -9999.0 0.0 -0.475 6.0 6.0 PPP2R1A 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 chromosome segregation -0.05 0.125 -9999.0 0.0 -0.418 22.0 22.0 PRC1 -0.003 0.12 -9999.0 0.0 -0.722 6.0 6.0 ECT2 -0.275 0.227 -9999.0 0.0 -0.452 137.0 137.0 C13orf34 -0.007 0.048 -9999.0 0.0 -0.437 1.0 1.0 NUDC -0.003 0.025 -9999.0 0.0 -9999.0 0.0 0.0 regulation of attachment of spindle microtubules to kinetochore -0.097 0.152 -9999.0 0.0 -0.372 45.0 45.0 spindle assembly -0.008 0.032 -9999.0 0.0 -0.131 1.0 1.0 spindle stabilization -0.008 0.021 -9999.0 0.0 -0.091 1.0 1.0 APC/C/HCDH1 0.02 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MKLP2/PLK1 -0.055 0.159 -9999.0 0.0 -0.473 27.0 27.0 CCNB1 -0.151 0.305 -9999.0 0.0 -0.732 48.0 48.0 PPP1CB 0.016 0.001 -9999.0 0.0 -9999.0 0.0 0.0 BTRC 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK2 0.006 0.028 -9999.0 0.0 -9999.0 0.0 0.0 TUBG1 -0.0 0.021 -9999.0 0.0 -9999.0 0.0 0.0 G2/M transition of mitotic cell cycle -0.257 0.246 -9999.0 0.0 -0.588 56.0 56.0 MLF1IP -0.042 0.172 -9999.0 0.0 -0.56 22.0 22.0 INCENP -0.0 0.086 -9999.0 0.0 -0.729 3.0 3.0