BCR signaling pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations JUN -0.191 0.284 -9999.0 0.0 -0.521 85.0 85.0 IKBKB -0.096 0.139 -9999.0 0.0 -0.28 27.0 27.0 AKT1 -0.093 0.172 0.243 2.0 -0.289 65.0 67.0 IKBKG -0.101 0.148 -9999.0 0.0 -0.3 28.0 28.0 CALM1 -0.315 0.341 -9999.0 0.0 -0.664 98.0 98.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K1 -0.282 0.398 -9999.0 0.0 -0.736 89.0 89.0 MAP3K7 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.349 0.368 -9999.0 0.0 -0.7 104.0 104.0 DOK1 0.014 0.05 -9999.0 0.0 -0.722 1.0 1.0 AP-1 -0.122 0.161 -9999.0 0.0 -0.301 74.0 74.0 LYN 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BLNK -0.001 0.106 -9999.0 0.0 -0.635 6.0 6.0 SHC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BCR complex -0.365 0.382 -9999.0 0.0 -0.717 113.0 113.0 CD22 -0.379 0.478 -9999.0 0.0 -0.913 90.0 90.0 CAMK2G -0.28 0.31 -9999.0 0.0 -0.599 98.0 98.0 CSNK2A1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 INPP5D -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHC/GRB2/SOS1 -0.24 0.261 -9999.0 0.0 -0.576 76.0 76.0 GO:0007205 -0.357 0.379 -9999.0 0.0 -0.719 104.0 104.0 SYK 0.014 0.049 -9999.0 0.0 -0.722 1.0 1.0 ELK1 -0.328 0.35 -9999.0 0.0 -0.675 101.0 101.0 NFATC1 -0.291 0.377 -9999.0 0.0 -0.682 100.0 100.0 B-cell antigen/BCR complex -0.365 0.382 -9999.0 0.0 -0.717 113.0 113.0 PAG1/CSK -0.135 0.21 -9999.0 0.0 -0.462 65.0 65.0 NFKBIB -0.019 0.049 -9999.0 0.0 -9999.0 0.0 0.0 HRAS -0.285 0.322 -9999.0 0.0 -0.619 98.0 98.0 NFKBIA -0.018 0.048 -9999.0 0.0 -9999.0 0.0 0.0 NF-kappa-B/RelA/I kappa B beta -0.005 0.039 -9999.0 0.0 -9999.0 0.0 0.0 RasGAP/Csk -0.347 0.374 -9999.0 0.0 -0.793 83.0 83.0 mol:GDP -0.334 0.352 -9999.0 0.0 -0.67 104.0 104.0 PTEN -0.001 0.106 -9999.0 0.0 -0.635 6.0 6.0 CD79B -0.23 0.316 -9999.0 0.0 -0.634 84.0 84.0 NF-kappa-B/RelA/I kappa B alpha -0.004 0.039 -9999.0 0.0 -9999.0 0.0 0.0 GRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K/BCAP/CD19 -0.308 0.37 -9999.0 0.0 -0.675 107.0 107.0 PIK3R1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 -0.364 0.387 -9999.0 0.0 -0.732 104.0 104.0 CSK 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FOS -0.333 0.35 -9999.0 0.0 -0.656 107.0 107.0 CHUK -0.101 0.148 -9999.0 0.0 -0.296 33.0 33.0 IBTK 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CARD11/BCL10/MALT1/TAK1 -0.289 0.281 -9999.0 0.0 -0.627 79.0 79.0 PTPN6 -0.347 0.438 -9999.0 0.0 -0.867 85.0 85.0 RELA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BCL2A1 -0.004 0.039 -9999.0 0.0 -0.113 13.0 13.0 VAV2 -0.445 0.522 -9999.0 0.0 -0.989 99.0 99.0 ubiquitin-dependent protein catabolic process -0.012 0.047 -9999.0 0.0 -9999.0 0.0 0.0 BTK -0.18 0.433 -9999.0 0.0 -1.198 34.0 34.0 CD19 -0.477 0.565 -9999.0 0.0 -1.045 101.0 101.0 MAP4K1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CD72 0.004 0.093 -9999.0 0.0 -0.679 4.0 4.0 PAG1 -0.174 0.297 -9999.0 0.0 -0.635 65.0 65.0 MAPK14 -0.216 0.328 -9999.0 0.0 -0.598 85.0 85.0 SH3BP5 0.014 0.044 -9999.0 0.0 -0.635 1.0 1.0 PIK3AP1 -0.362 0.388 -9999.0 0.0 -0.757 99.0 99.0 B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 -0.415 0.454 -9999.0 0.0 -0.841 105.0 105.0 RAF1 -0.255 0.3 -9999.0 0.0 -0.569 97.0 97.0 RasGAP/p62DOK/SHIP -0.337 0.363 -9999.0 0.0 -0.767 84.0 84.0 CD79A -0.285 0.325 -9999.0 0.0 -0.635 103.0 103.0 re-entry into mitotic cell cycle -0.124 0.163 -9999.0 0.0 -0.305 75.0 75.0 RASA1 0.01 0.07 -9999.0 0.0 -0.722 2.0 2.0 MAPK3 -0.192 0.247 -9999.0 0.0 -0.507 69.0 69.0 MAPK1 -0.191 0.245 -9999.0 0.0 -0.505 69.0 69.0 CD72/SHP1 -0.295 0.418 -9999.0 0.0 -0.8 83.0 83.0 NFKB1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK8 -0.216 0.328 -9999.0 0.0 -0.598 85.0 85.0 actin cytoskeleton organization -0.315 0.419 -9999.0 0.0 -0.758 99.0 99.0 NF-kappa-B/RelA -0.002 0.076 -9999.0 0.0 -9999.0 0.0 0.0 Calcineurin -0.264 0.262 -9999.0 0.0 -0.601 72.0 72.0 PI3K -0.292 0.308 -9999.0 0.0 -0.637 93.0 93.0 B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 -0.4 0.403 -9999.0 0.0 -0.786 104.0 104.0 SOS1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Bam32/HPK1 -0.33 0.438 -9999.0 0.0 -0.842 87.0 87.0 DAPP1 -0.411 0.501 -9999.0 0.0 -0.994 87.0 87.0 cytokine secretion -0.261 0.341 -9999.0 0.0 -0.616 100.0 100.0 mol:DAG -0.364 0.387 -9999.0 0.0 -0.732 104.0 104.0 PLCG2 -0.306 0.326 -9999.0 0.0 -0.635 110.0 110.0 MAP2K1 -0.223 0.273 -9999.0 0.0 -0.551 80.0 80.0 B-cell antigen/BCR complex/FcgammaRIIB -0.398 0.426 -9999.0 0.0 -0.749 118.0 118.0 mol:PI-3-4-5-P3 -0.189 0.205 0.328 2.0 -0.425 84.0 86.0 ETS1 -0.241 0.277 -9999.0 0.0 -0.599 69.0 69.0 B-cell antigen/BCR complex/LYN/SYK/BLNK -0.283 0.304 -9999.0 0.0 -0.671 76.0 76.0 B-cell antigen/BCR complex/LYN -0.408 0.516 -9999.0 0.0 -0.98 90.0 90.0 MALT1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRAF6 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 -0.355 0.467 -9999.0 0.0 -0.846 99.0 99.0 B-cell antigen/BCR complex/LYN/SYK -0.364 0.413 -9999.0 0.0 -0.861 83.0 83.0 CARD11 -0.354 0.371 -9999.0 0.0 -0.702 106.0 106.0 FCGR2B -0.13 0.273 -9999.0 0.0 -0.637 50.0 50.0 PPP3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BCL10 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IKK complex -0.023 0.062 -9999.0 0.0 -9999.0 0.0 0.0 PTPRC -0.018 0.147 -9999.0 0.0 -0.635 12.0 12.0 PDPK1 -0.088 0.166 0.232 2.0 -0.283 64.0 66.0 PPP3CB 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PPP3CC 0.002 0.097 -9999.0 0.0 -0.635 5.0 5.0 POU2F2 0.004 0.029 -9999.0 0.0 -9999.0 0.0 0.0