E-cadherin signaling in keratinocytes Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations keratinocyte differentiation 0.042 0.081 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction organization -0.087 0.068 -9999.0 0.0 -0.387 6.0 6.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.038 0.112 -9999.0 0.0 -0.547 2.0 2.0 FMN1 0.029 0.067 -9999.0 0.0 -0.31 2.0 2.0 mol:IP3 -0.026 0.083 -9999.0 0.0 -0.435 2.0 2.0 E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin 0.03 0.07 -9999.0 0.0 -0.325 2.0 2.0 CTNNB1 -0.0 0.11 -9999.0 0.0 -0.725 5.0 5.0 AKT1 0.045 0.064 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin 0.037 0.09 -9999.0 0.0 -0.425 6.0 6.0 CTNND1 0.017 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.04 0.066 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.04 0.067 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.038 0.072 -9999.0 0.0 -9999.0 0.0 0.0 JUB -0.349 0.101 -9999.0 0.0 -0.367 211.0 211.0 EGFR(dimer) 0.03 0.091 -9999.0 0.0 -0.427 3.0 3.0 E-cadherin/beta catenin-gamma catenin -0.018 0.091 -9999.0 0.0 -0.41 11.0 11.0 mol:PI-3-4-5-P3 -0.016 0.049 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.017 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.016 0.05 -9999.0 0.0 -9999.0 0.0 0.0 FYN 0.043 0.098 -9999.0 0.0 -0.495 1.0 1.0 mol:Ca2+ -0.026 0.081 -9999.0 0.0 -0.424 2.0 2.0 JUP 0.017 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.017 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:DAG -0.026 0.083 -9999.0 0.0 -0.435 2.0 2.0 CDH1 -0.001 0.105 -9999.0 0.0 -0.633 6.0 6.0 RhoA/GDP 0.038 0.112 -9999.0 0.0 -0.547 2.0 2.0 establishment of polarity of embryonic epithelium 0.04 0.066 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.002 0.099 -9999.0 0.0 -0.652 5.0 5.0 CASR 0.032 0.107 -9999.0 0.0 -0.452 4.0 4.0 RhoA/GTP -0.023 0.073 -9999.0 0.0 -0.383 2.0 2.0 AKT2 0.045 0.064 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.039 0.065 -9999.0 0.0 -9999.0 0.0 0.0 apoptosis 0.014 0.044 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.017 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.029 0.119 -9999.0 0.0 -0.491 5.0 5.0 PIP5K1A 0.04 0.067 -9999.0 0.0 -9999.0 0.0 0.0 PLCG1 -0.027 0.085 -9999.0 0.0 -0.445 2.0 2.0 Rac1/GTP -0.019 0.067 -9999.0 0.0 -0.386 3.0 3.0 homophilic cell adhesion 0.001 0.003 -9999.0 0.0 -9999.0 0.0 0.0