TCR signaling in naïve CD8+ T cells Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations GRB2/SOS1/SHC -0.042 0.129 -9999.0 0.0 -0.548 11.0 11.0 FYN -0.016 0.216 -9999.0 0.0 -0.712 14.0 14.0 LAT/GRAP2/SLP76 -0.043 0.14 -9999.0 0.0 -0.582 10.0 10.0 IKBKB 0.014 0.05 -9999.0 0.0 -0.722 1.0 1.0 AKT1 0.022 0.15 -9999.0 0.0 -0.484 12.0 12.0 B2M -0.009 0.13 -9999.0 0.0 -0.64 9.0 9.0 IKBKG -0.017 0.037 -9999.0 0.0 -0.175 1.0 1.0 MAP3K8 -0.086 0.256 -9999.0 0.0 -0.722 31.0 31.0 mol:Ca2+ -0.003 0.021 -9999.0 0.0 -0.144 4.0 4.0 integrin-mediated signaling pathway 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LAT/GRAP2/SLP76/VAV1/PI3K Class IA 0.006 0.211 -9999.0 0.0 -0.745 12.0 12.0 TRPV6 -0.01 0.099 -9999.0 0.0 -0.738 4.0 4.0 CD28 -0.062 0.214 -9999.0 0.0 -0.638 27.0 27.0 SHC1 0.008 0.196 -9999.0 0.0 -0.726 11.0 11.0 receptor internalization -0.007 0.214 -9999.0 0.0 -0.731 14.0 14.0 PRF1 0.013 0.183 -9999.0 0.0 -0.697 10.0 10.0 KRAS 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 COT/AKT1 -0.014 0.162 -9999.0 0.0 -0.384 19.0 19.0 LAT 0.005 0.198 -9999.0 0.0 -0.725 11.0 11.0 EntrezGene:6955 0.001 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CD3D -0.011 0.137 -9999.0 0.0 -0.64 10.0 10.0 CD3E 0.017 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CD3G -0.015 0.145 -9999.0 0.0 -0.648 11.0 11.0 RASGRP2 0.01 0.033 -9999.0 0.0 -0.19 4.0 4.0 RASGRP1 0.027 0.151 -9999.0 0.0 -0.464 12.0 12.0 HLA-A 0.003 0.098 -9999.0 0.0 -0.641 5.0 5.0 RASSF5 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A/GTP/RAPL 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.036 0.055 -9999.0 0.0 -0.138 2.0 2.0 PDK1/CARD11/BCL10/MALT1/TRAF6 -0.032 0.066 -9999.0 0.0 -0.261 4.0 4.0 PRKCA -0.039 0.083 -9999.0 0.0 -0.308 12.0 12.0 GRAP2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 -0.057 0.136 0.275 1.0 -0.476 14.0 15.0 EntrezGene:6957 0.001 0.004 -9999.0 0.0 -9999.0 0.0 0.0 TCR/CD3/MHC I/CD8 0.001 0.195 -9999.0 0.0 -0.714 12.0 12.0 ORAI1 0.01 0.05 0.372 4.0 -9999.0 0.0 4.0 CSK -0.002 0.199 -9999.0 0.0 -0.737 11.0 11.0 B7 family/CD28 -0.096 0.23 -9999.0 0.0 -0.731 20.0 20.0 CHUK 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TCR/CD3/MHC I/CD8/LCK/ZAP-70 -0.012 0.228 -9999.0 0.0 -0.835 12.0 12.0 PTPN6 0.002 0.203 -9999.0 0.0 -0.732 12.0 12.0 VAV1 -0.017 0.241 -9999.0 0.0 -0.856 13.0 13.0 Monovalent TCR/CD3 -0.012 0.195 -9999.0 0.0 -0.707 13.0 13.0 CBL 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LCK -0.014 0.216 -9999.0 0.0 -0.712 14.0 14.0 PAG1 -0.065 0.243 -9999.0 0.0 -0.668 18.0 18.0 RAP1A 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TCR/CD3/MHC I/CD8/LCK -0.016 0.232 -9999.0 0.0 -0.856 12.0 12.0 CD80 0.004 0.099 -9999.0 0.0 -0.724 4.0 4.0 CD86 -0.016 0.144 -9999.0 0.0 -0.646 11.0 11.0 PDK1/CARD11/BCL10/MALT1 -0.04 0.081 -9999.0 0.0 -0.293 9.0 9.0 HRAS 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GO:0035030 -0.015 0.214 -9999.0 0.0 -0.613 18.0 18.0 CD8A 0.001 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CD8B 0.017 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PTPRC -0.018 0.148 -9999.0 0.0 -0.639 12.0 12.0 PDK1/PKC theta 0.023 0.185 -9999.0 0.0 -0.61 12.0 12.0 CSK/PAG1 -0.056 0.234 -9999.0 0.0 -0.678 15.0 15.0 SOS1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 peptide-MHC class I -0.01 0.136 -9999.0 0.0 -0.575 11.0 11.0 GRAP2/SLP76 -0.05 0.167 -9999.0 0.0 -0.69 11.0 11.0 STIM1 0.007 0.026 -9999.0 0.0 -9999.0 0.0 0.0 RAS family/GTP 0.045 0.07 -9999.0 0.0 -0.244 1.0 1.0 TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin -0.011 0.236 -9999.0 0.0 -0.802 14.0 14.0 mol:DAG -0.055 0.118 -9999.0 0.0 -0.423 14.0 14.0 RAP1A/GDP 0.018 0.024 -9999.0 0.0 -9999.0 0.0 0.0 PLCG1 -0.033 0.186 -9999.0 0.0 -0.723 15.0 15.0 CD247 -0.014 0.143 -9999.0 0.0 -0.639 11.0 11.0 cytotoxic T cell degranulation 0.015 0.177 -9999.0 0.0 -0.67 10.0 10.0 RAP1A/GTP -0.002 0.009 -9999.0 0.0 -0.068 3.0 3.0 mol:PI-3-4-5-P3 0.014 0.176 -9999.0 0.0 -0.591 12.0 12.0 LAT/GRAP2/SLP76/VAV1/PLCgamma1 -0.073 0.174 0.298 1.0 -0.632 14.0 15.0 NRAS 0.007 0.085 -9999.0 0.0 -0.722 3.0 3.0 ZAP70 0.017 0.001 -9999.0 0.0 -9999.0 0.0 0.0 GRB2/SOS1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LAT/GRAP2/SLP76/VAV1 -0.059 0.161 -9999.0 0.0 -0.622 13.0 13.0 MALT1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRAF6 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CD8 heterodimer 0.012 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CARD11 -0.046 0.207 -9999.0 0.0 -0.722 19.0 19.0 PRKCB -0.04 0.082 -9999.0 0.0 -0.289 14.0 14.0 PRKCE -0.038 0.08 -9999.0 0.0 -0.294 12.0 12.0 PRKCQ 0.009 0.206 -9999.0 0.0 -0.714 12.0 12.0 LCP2 0.004 0.096 -9999.0 0.0 -0.701 4.0 4.0 BCL10 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of survival gene product expression 0.025 0.131 -9999.0 0.0 -0.405 12.0 12.0 IKK complex 0.039 0.058 -9999.0 0.0 -0.127 1.0 1.0 RAS family/GDP -0.003 0.011 -9999.0 0.0 -0.081 3.0 3.0 MAP3K14 0.003 0.128 -9999.0 0.0 -0.302 13.0 13.0 PDPK1 0.027 0.144 -9999.0 0.0 -0.453 12.0 12.0 TCR/CD3/MHC I/CD8/Fyn -0.01 0.219 -9999.0 0.0 -0.843 11.0 11.0