IGF1 pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations NCK2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTK2 0.014 0.05 -9999.0 0.0 -0.722 1.0 1.0 CRKL -0.164 0.184 -9999.0 0.0 -0.684 4.0 4.0 GRB2/SOS1/SHC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HRAS 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IRS1/Crk -0.167 0.187 -9999.0 0.0 -0.683 5.0 5.0 IGF-1R heterotetramer/IGF1/PTP1B -0.205 0.181 -9999.0 0.0 -0.468 4.0 4.0 AKT1 -0.113 0.161 -9999.0 0.0 -0.566 4.0 4.0 BAD -0.097 0.153 -9999.0 0.0 -0.521 4.0 4.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRK -0.166 0.187 -9999.0 0.0 -0.679 5.0 5.0 IGF-1R heterotetramer/IGF1/IRS1/Shp2 -0.183 0.171 -9999.0 0.0 -0.696 5.0 5.0 RAF1 -0.087 0.148 -9999.0 0.0 -0.486 4.0 4.0 IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos -0.167 0.155 -9999.0 0.0 -0.654 4.0 4.0 YWHAZ 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1/IRS1 -0.202 0.185 -9999.0 0.0 -0.359 125.0 125.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RPS6KB1 -0.114 0.164 -9999.0 0.0 -0.577 5.0 5.0 GNB2L1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of MAPKKK cascade -0.079 0.132 -9999.0 0.0 -0.414 4.0 4.0 PXN 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GRB2/SOS1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HRAS/GTP -0.142 0.133 -9999.0 0.0 -0.579 4.0 4.0 IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc -0.153 0.135 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer -0.027 0.04 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1/IRS/Nck -0.182 0.168 -9999.0 0.0 -0.69 4.0 4.0 Crk/p130 Cas/Paxillin -0.156 0.147 -9999.0 0.0 -0.614 5.0 5.0 IGF1R -0.027 0.04 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.356 0.329 -9999.0 0.0 -0.646 125.0 125.0 IRS2/Crk -0.149 0.182 -9999.0 0.0 -0.65 6.0 6.0 PI3K -0.166 0.154 -9999.0 0.0 -0.648 4.0 4.0 apoptosis 0.077 0.137 0.439 4.0 -9999.0 0.0 4.0 HRAS/GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PRKCD -0.195 0.224 -9999.0 0.0 -0.392 125.0 125.0 RAF1/14-3-3 E -0.069 0.134 -9999.0 0.0 -9999.0 0.0 0.0 BAD/14-3-3 -0.081 0.144 -9999.0 0.0 -0.471 4.0 4.0 PRKCZ -0.123 0.16 -9999.0 0.0 -0.575 4.0 4.0 Crk/p130 Cas/Paxillin/FAK1 -0.112 0.111 -9999.0 0.0 -0.496 2.0 2.0 PTPN1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 -0.216 0.235 -9999.0 0.0 -0.422 125.0 125.0 BCAR1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1/SHC/GRB10 -0.2 0.189 -9999.0 0.0 -0.629 14.0 14.0 mol:GDP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SOS1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IRS1/NCK2 -0.164 0.183 -9999.0 0.0 -0.684 4.0 4.0 GRB10 -0.03 0.18 -9999.0 0.0 -0.722 14.0 14.0 PTPN11 -0.166 0.188 -9999.0 0.0 -0.692 5.0 5.0 IRS1 -0.19 0.198 -9999.0 0.0 -0.358 125.0 125.0 IRS2 -0.166 0.188 -9999.0 0.0 -0.692 5.0 5.0 IGF-1R heterotetramer/IGF1 -0.271 0.239 -9999.0 0.0 -0.48 125.0 125.0 GRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PDPK1 -0.129 0.168 -9999.0 0.0 -0.607 4.0 4.0 YWHAE 0.014 0.05 -9999.0 0.0 -0.722 1.0 1.0 PRKD1 -0.205 0.23 -9999.0 0.0 -0.638 7.0 7.0 SHC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0