Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.016 0.227 -9999.0 0.0 -0.692 19.0 19.0 IHH 0.02 0.063 -9999.0 0.0 -0.788 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.158 0.211 -9999.0 0.0 -0.403 87.0 87.0 LRPAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.157 0.209 0.4 87.0 -9999.0 0.0 87.0 SMO/beta Arrestin2 0.046 0.101 -9999.0 0.0 -0.704 1.0 1.0 SMO 0.04 0.106 -9999.0 0.0 -0.751 1.0 1.0 AKT1 0.05 0.053 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.04 0.105 -9999.0 0.0 -0.736 1.0 1.0 STIL -0.048 0.214 -9999.0 0.0 -0.631 12.0 12.0 DHH N/PTCH2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.04 0.1 -9999.0 0.0 -0.698 1.0 1.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.027 0.213 -9999.0 0.0 -1.154 4.0 4.0 determination of left/right symmetry 0.04 0.105 -9999.0 0.0 -0.736 1.0 1.0 PIK3R1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.028 0.21 -9999.0 0.0 -1.13 4.0 4.0 IHH N/Hhip -0.087 0.226 -9999.0 0.0 -0.514 48.0 48.0 DHH N/Hhip -0.1 0.19 -9999.0 0.0 -0.462 48.0 48.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.04 0.105 -9999.0 0.0 -0.736 1.0 1.0 pancreas development -0.124 0.268 -9999.0 0.0 -0.634 48.0 48.0 HHAT -0.054 0.202 -9999.0 0.0 -0.635 24.0 24.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.194 0.308 -9999.0 0.0 -0.642 71.0 71.0 somite specification 0.04 0.105 -9999.0 0.0 -0.736 1.0 1.0 SHH Np/Cholesterol/PTCH1 0.004 0.15 -9999.0 0.0 -0.575 4.0 4.0 SHH Np/Cholesterol/PTCH2 -0.044 0.123 -9999.0 0.0 -0.372 26.0 26.0 SHH Np/Cholesterol/Megalin -0.045 0.125 -9999.0 0.0 -0.374 27.0 27.0 SHH -0.029 0.169 -9999.0 0.0 -0.485 26.0 26.0 catabolic process 0.036 0.114 -9999.0 0.0 -0.495 4.0 4.0 SMO/Vitamin D3 0.015 0.148 -9999.0 0.0 -0.562 4.0 4.0 SHH Np/Cholesterol/Hhip -0.12 0.207 -9999.0 0.0 -0.421 63.0 63.0 LRP2 0.014 0.05 -9999.0 0.0 -0.722 1.0 1.0 receptor-mediated endocytosis -0.051 0.111 -9999.0 0.0 -0.561 3.0 3.0 SHH Np/Cholesterol/BOC -0.044 0.123 -9999.0 0.0 -0.534 3.0 3.0 SHH Np/Cholesterol/CDO -0.044 0.123 -9999.0 0.0 -0.534 3.0 3.0 mesenchymal cell differentiation 0.119 0.205 0.418 63.0 -9999.0 0.0 63.0 mol:Vitamin D3 0.009 0.152 -9999.0 0.0 -0.575 4.0 4.0 IHH N/PTCH2 0.028 0.039 -9999.0 0.0 -0.507 1.0 1.0 CDON 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.035 0.114 -9999.0 0.0 -0.5 4.0 4.0 Megalin/LRPAP1 -0.002 0.036 -9999.0 0.0 -0.539 1.0 1.0 PTCH2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.045 0.126 -9999.0 0.0 -0.384 26.0 26.0 PTCH1 0.036 0.114 -9999.0 0.0 -0.497 4.0 4.0 HHIP -0.124 0.268 -9999.0 0.0 -0.635 48.0 48.0