IL1-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations UBC13/UEV1A 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PRKCZ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7IP2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ERC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 -0.052 0.088 -9999.0 0.0 -0.37 4.0 4.0 IRAK/TOLLIP 0.03 0.043 -9999.0 0.0 -0.418 2.0 2.0 IKBKB 0.014 0.05 -9999.0 0.0 -0.722 1.0 1.0 IKBKG 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL1 alpha/IL1R2 -0.414 0.288 -9999.0 0.0 -0.571 161.0 161.0 IL1A -0.316 0.368 -9999.0 0.0 -0.722 100.0 100.0 IL1B -0.111 0.252 -9999.0 0.0 -0.542 55.0 55.0 IRAK/TRAF6/p62/Atypical PKCs -0.013 0.065 -9999.0 0.0 -9999.0 0.0 0.0 IL1R2 -0.239 0.318 -9999.0 0.0 -0.635 87.0 87.0 IL1R1 -0.007 0.121 -9999.0 0.0 -0.635 8.0 8.0 IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP -0.043 0.078 0.205 2.0 -9999.0 0.0 2.0 TOLLIP 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TICAM2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K3 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TAK1/TAB1/TAB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IKK complex/ELKS 0.082 0.035 -9999.0 0.0 -9999.0 0.0 0.0 JUN 0.056 0.083 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL1 beta fragment/IL1R1/IL1RAP/PI3K -0.108 0.181 -9999.0 0.0 -0.741 6.0 6.0 IL1 alpha/IL1R1/IL1RAP/MYD88 -0.207 0.223 -9999.0 0.0 -0.81 6.0 6.0 PIK3R1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 -0.192 0.207 -9999.0 0.0 -0.766 6.0 6.0 IL1 beta fragment/IL1R1/IL1RAP -0.125 0.206 -9999.0 0.0 -0.819 6.0 6.0 NFKB1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK8 0.056 0.065 -9999.0 0.0 -9999.0 0.0 0.0 IRAK1 0.021 0.047 -9999.0 0.0 -0.469 2.0 2.0 IL1RN/IL1R1 -0.172 0.249 -9999.0 0.0 -0.53 72.0 72.0 IRAK4 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PRKCI -0.003 0.12 -9999.0 0.0 -0.722 6.0 6.0 TRAF6 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP -0.021 0.123 -9999.0 0.0 -0.386 4.0 4.0 CHUK 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL1 beta fragment/IL1R1/IL1RAP/MYD88s -0.125 0.206 -9999.0 0.0 -0.819 6.0 6.0 IL1 beta/IL1R2 -0.263 0.256 -9999.0 0.0 -0.467 125.0 125.0 IRAK/TRAF6/TAK1/TAB1/TAB2 -0.003 0.032 -9999.0 0.0 -9999.0 0.0 0.0 NF kappa B1 p50/RelA -0.095 0.159 -9999.0 0.0 -0.663 6.0 6.0 IRAK3 -0.01 0.138 -9999.0 0.0 -0.722 8.0 8.0 IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 -0.111 0.185 -9999.0 0.0 -0.75 6.0 6.0 IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP -0.082 0.142 -9999.0 0.0 -0.434 6.0 6.0 IL1 alpha/IL1R1/IL1RAP -0.231 0.247 -9999.0 0.0 -0.481 101.0 101.0 RELA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7IP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SQSTM1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYD88 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IRAK/TRAF6/MEKK3 -0.003 0.036 -9999.0 0.0 -0.386 2.0 2.0 IL1RAP -0.003 0.12 -9999.0 0.0 -0.722 6.0 6.0 UBE2N 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IRAK/TRAF6 -0.092 0.153 -9999.0 0.0 -0.613 7.0 7.0 CASP1 -0.032 0.177 -9999.0 0.0 -0.668 16.0 16.0 IL1RN/IL1R2 -0.333 0.262 -9999.0 0.0 -0.518 143.0 143.0 IL1 beta fragment/IL1R1/IL1RAP/MYD88 -0.116 0.192 -9999.0 0.0 -0.775 6.0 6.0 TMEM189-UBE2V1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP -0.051 0.121 -9999.0 0.0 -0.378 6.0 6.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL1RN -0.196 0.335 -9999.0 0.0 -0.722 64.0 64.0 TRAF6/TAK1/TAB1/TAB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K6 0.047 0.067 -9999.0 0.0 -9999.0 0.0 0.0