IL6-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BCL2L1 -0.244 0.217 -9999.0 0.0 -0.745 7.0 7.0 CRP -0.243 0.215 -9999.0 0.0 -0.732 6.0 6.0 cell cycle arrest -0.282 0.245 -9999.0 0.0 -0.743 22.0 22.0 TIMP1 -0.375 0.271 -9999.0 0.0 -0.67 77.0 77.0 IL6ST 0.012 0.011 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.275 0.208 -9999.0 0.0 -0.52 67.0 67.0 AP1 -0.058 0.151 -9999.0 0.0 -0.65 2.0 2.0 GAB2 0.021 0.008 -9999.0 0.0 -9999.0 0.0 0.0 TNFSF11 -0.299 0.282 -9999.0 0.0 -0.81 31.0 31.0 HSP90B1 -0.024 0.093 -9999.0 0.0 -0.583 4.0 4.0 GAB1 0.013 0.062 -9999.0 0.0 -0.634 2.0 2.0 MAPK14 -0.231 0.215 -9999.0 0.0 -0.599 28.0 28.0 AKT1 0.065 0.027 -9999.0 0.0 -9999.0 0.0 0.0 FOXO1 0.058 0.075 -9999.0 0.0 -0.461 1.0 1.0 MAP2K6 -0.263 0.219 -9999.0 0.0 -0.551 58.0 58.0 mol:GTP -0.001 0.002 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K4 -0.275 0.218 -9999.0 0.0 -0.595 42.0 42.0 MITF -0.262 0.202 -9999.0 0.0 -0.532 54.0 54.0 positive regulation of NF-kappaB transcription factor activity 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TYK2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 A2M -0.163 0.513 -9999.0 0.0 -1.486 29.0 29.0 CEBPB 0.008 0.12 -9999.0 0.0 -0.714 6.0 6.0 GRB2/SOS1/GAB family/SHP2 -0.064 0.092 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 -0.294 0.257 -9999.0 0.0 -0.783 22.0 22.0 STAT1 -0.047 0.09 -9999.0 0.0 -0.331 19.0 19.0 CEBPD -0.244 0.217 -9999.0 0.0 -0.683 14.0 14.0 PIK3CA 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.008 0.013 -9999.0 0.0 -9999.0 0.0 0.0 JUN -0.0 0.11 -9999.0 0.0 -0.724 5.0 5.0 PIAS3/MITF -0.241 0.195 -9999.0 0.0 -0.499 55.0 55.0 MAPK11 -0.233 0.221 -9999.0 0.0 -0.676 19.0 19.0 STAT3 (dimer)/FOXO1 -0.219 0.22 -9999.0 0.0 -0.69 14.0 14.0 GRB2/SOS1/GAB family -0.222 0.177 -9999.0 0.0 -0.525 24.0 24.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/HCK -0.292 0.217 -9999.0 0.0 -0.541 75.0 75.0 GRB2 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 JAK2 0.004 0.098 -9999.0 0.0 -0.722 4.0 4.0 LBP -0.185 0.19 -9999.0 0.0 -0.72 5.0 5.0 PIK3R1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JAK1 0.013 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MYC -0.401 0.305 -9999.0 0.0 -0.752 59.0 59.0 FGG -0.244 0.218 -9999.0 0.0 -0.767 6.0 6.0 macrophage differentiation -0.282 0.245 -9999.0 0.0 -0.743 22.0 22.0 IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 -0.381 0.273 -9999.0 0.0 -0.742 62.0 62.0 JUNB -0.239 0.211 -9999.0 0.0 -0.706 7.0 7.0 FOS -0.081 0.234 -9999.0 0.0 -0.64 33.0 33.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 -0.288 0.213 -9999.0 0.0 -0.53 71.0 71.0 STAT1/PIAS1 -0.256 0.187 -9999.0 0.0 -0.489 59.0 59.0 GRB2/SOS1/GAB family/SHP2/PI3K 0.047 0.032 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 (dimer) -0.288 0.257 -9999.0 0.0 -0.777 22.0 22.0 PRKCD -0.27 0.225 -9999.0 0.0 -0.613 36.0 36.0 IL6R -0.343 0.326 -9999.0 0.0 -0.638 122.0 122.0 SOCS3 -0.208 0.219 -9999.0 0.0 -0.802 12.0 12.0 gp130 (dimer)/JAK1/JAK1/LMO4 -0.003 0.095 -9999.0 0.0 -0.453 8.0 8.0 Rac1/GTP -0.29 0.197 -9999.0 0.0 -0.508 78.0 78.0 HCK -0.044 0.191 -9999.0 0.0 -0.634 21.0 21.0 MAPKKK cascade -0.014 0.079 -9999.0 0.0 -9999.0 0.0 0.0 bone resorption -0.285 0.266 -9999.0 0.0 -0.758 31.0 31.0 IRF1 -0.247 0.224 -9999.0 0.0 -0.779 8.0 8.0 mol:GDP -0.293 0.216 -9999.0 0.0 -0.538 72.0 72.0 SOS1 0.02 0.008 -9999.0 0.0 -9999.0 0.0 0.0 VAV1 -0.297 0.219 -9999.0 0.0 -0.547 72.0 72.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 -0.305 0.265 -9999.0 0.0 -0.635 61.0 61.0 PTPN11 -0.017 0.026 -9999.0 0.0 -9999.0 0.0 0.0 IL6/IL6RA -0.486 0.319 -9999.0 0.0 -0.628 173.0 173.0 gp130 (dimer)/TYK2/TYK2/LMO4 -0.008 0.092 -9999.0 0.0 -0.452 8.0 8.0 gp130 (dimer)/JAK2/JAK2/LMO4 -0.016 0.131 -9999.0 0.0 -0.574 10.0 10.0 IL6 -0.33 0.369 -9999.0 0.0 -0.726 103.0 103.0 PIAS3 0.014 0.05 -9999.0 0.0 -0.722 1.0 1.0 PTPRE 0.015 0.05 -9999.0 0.0 -0.71 1.0 1.0 PIAS1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.016 0.001 -9999.0 0.0 -9999.0 0.0 0.0 IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 -0.272 0.192 -9999.0 0.0 -0.525 60.0 60.0 LMO4 -0.017 0.142 -9999.0 0.0 -0.706 9.0 9.0 STAT3 (dimer)/PIAS3 -0.294 0.222 -9999.0 0.0 -0.717 24.0 24.0 MCL1 0.072 0.026 -9999.0 0.0 -9999.0 0.0 0.0