Clinical Features	MRNA_CNMF		MRNA_CHIERARCHICAL		MIR_CNMF		MIR_CHIERARCHICAL		CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
PIK3R1	32 (11%)	252	0.96022	1	0.77945	1	0.46716	1	0.20455	1	0.11497	1	0.8399	1	0.98818	1	0.27286	1	0.40561	1	0.64893	1
BRAF	6 (2%)	278	0.39487	1	0.56675	1	0.61599	1	0.17539	1	0.58641	1	NA	NA	1	1	0.078076	1	0.79121	1	1	1
EGFR	74 (26%)	210	0.00048467	0.41	0.065575	1	0.24234	1	0.21674	1	7.4856e-07	0.000643	0.010787	1	6.3736e-05	0.0543	1.463e-06	0.00125	0.041343	1	0.35695	1
IDH1	14 (5%)	270	1.129e-06	0.000969	4.4137e-07	0.00038	0.00022729	0.193	1.2416e-05	0.0106	1.675e-05	0.0143	0.0012058	1	0.0035226	1	0.020325	1	0.00071234	0.601	0.0026329	1
PTEN	87 (31%)	197	0.45845	1	0.36574	1	0.045214	1	0.59362	1	0.58358	1	0.94973	1	0.37848	1	0.38945	1	0.27044	1	0.19564	1
TP53	79 (28%)	205	4.163e-05	0.0356	0.00050204	0.424	0.00031308	0.265	0.027184	1	0.0001659	0.141	0.0083017	1	0.038377	1	0.0096772	1	0.0018446	1	0.037471	1
PIK3CA	30 (11%)	254	0.68911	1	0.19544	1	0.57127	1	0.78456	1	0.50102	1	0.62736	1	0.7545	1	0.28115	1	0.26203	1	0.83762	1
RB1	24 (8%)	260	0.0065195	1	0.026526	1	0.065318	1	0.35679	1	0.087318	1	0.02704	1	0.4926	1	0.69117	1	0.081778	1	0.075359	1
NF1	29 (10%)	255	0.043512	1	0.070969	1	0.089745	1	0.50067	1	0.0015432	1	0.0039612	1	0.22964	1	0.11973	1	0.56596	1	0.91494	1
SPTA1	26 (9%)	258	0.7049	1	0.035394	1	0.54329	1	0.91318	1	0.33516	1	0.22325	1	0.50769	1	1	1	0.018014	1	0.57319	1
KRTAP4-11	9 (3%)	275	0.11348	1	0.087298	1	1	1	0.65775	1	0.69309	1	0.34314	1	0.11631	1	0.47355	1	0.20918	1	0.082293	1
GABRA6	11 (4%)	273	0.12603	1	0.42613	1	0.50602	1	0.48613	1	0.36535	1	0.94344	1	0.31791	1	0.47355	1	0.12381	1	1	1
KEL	15 (5%)	269	0.16241	1	0.48987	1	1	1	1	1	0.39411	1	0.17876	1	0.37643	1	0.91054	1	0.4076	1	0.90791	1
CDH18	11 (4%)	273	0.038428	1	0.016553	1	0.10414	1	0.25303	1	0.85328	1	0.25762	1	0.79104	1	0.77563	1	0.31801	1	0.049018	1
PRB2	6 (2%)	278	0.28414	1	1	1	0.44139	1	0.63399	1	0.77179	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
RPL5	7 (2%)	277	0.52751	1	0.17352	1	0.38762	1	0.67941	1	1	1	0.8822	1	0.843	1	0.53203	1	0.46454	1	1	1
SEMA3C	11 (4%)	273	0.044782	1	0.29561	1	0.14677	1	0.38347	1	0.29293	1	NA	NA	0.3388	1	0.53203	1	0.10276	1	0.64949	1
TPTE2	8 (3%)	276	0.90785	1	1	1	0.31832	1	0.28932	1	0.27088	1	0.50646	1	0.62449	1	0.4088	1	0.37597	1	0.74053	1
ZNF844	6 (2%)	278	0.69328	1	0.87422	1	0.14284	1	0.76721	1	0.19207	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
OR8K3	7 (2%)	277	0.62498	1	0.37554	1	0.76249	1	0.46195	1	0.078286	1	0.76484	1	0.90457	1	0.82051	1	1	1	0.7639	1
OR5AR1	7 (2%)	277	0.24082	1	0.31161	1	0.38762	1	0.67941	1	0.43255	1	0.8822	1	0.51406	1	0.85795	1	NA	NA	NA	NA
STAG2	12 (4%)	272	0.84956	1	0.20407	1	0.21044	1	0.13216	1	0.75636	1	0.67615	1	0.0069359	1	0.18373	1	0.47875	1	0.77076	1
SEMG1	8 (3%)	276	0.49344	1	0.11653	1	0.7618	1	1	1	0.14596	1	NA	NA	NA	NA	NA	NA	1	1	0.7639	1
CDC27	6 (2%)	278	0.24082	1	0.37554	1	0.26132	1	0.29017	1	0.44872	1	0.13828	1	0.27836	1	0.32478	1	NA	NA	NA	NA
PDGFRA	11 (4%)	273	0.33287	1	0.22331	1	0.72853	1	0.84563	1	0.54789	1	NA	NA	1	1	0.8515	1	0.026477	1	0.12858	1
ADAM29	9 (3%)	275	0.82042	1	0.7296	1	0.70107	1	0.79372	1	0.83522	1	NA	NA	0.4888	1	0.67306	1	0.055896	1	0.38432	1
SULT1B1	6 (2%)	278	0.04417	1	0.61692	1	0.27037	1	0.37009	1	0.28896	1	NA	NA	0.49598	1	0.5881	1	0.46645	1	0.80154	1
ABCC9	11 (4%)	273	0.1201	1	0.31628	1	0.24634	1	0.73549	1	0.50324	1	0.016172	1	0.45258	1	0.66075	1	0.33629	1	0.37041	1
NLRP5	12 (4%)	272	0.86146	1	1	1	0.92867	1	0.37654	1	0.54789	1	0.47693	1	0.91253	1	0.22065	1	0.72044	1	0.56783	1
LZTR1	10 (4%)	274	0.70647	1	0.79518	1	0.75379	1	1	1	0.91668	1	0.13805	1	0.83925	1	1	1	0.17292	1	0.53567	1
CALCR	8 (3%)	276	0.25347	1	0.87422	1	0.92965	1	0.73574	1	0.20759	1	1	1	0.2623	1	0.50561	1	NA	NA	NA	NA
QKI	5 (2%)	279	0.04417	1	0.31161	1	1	1	0.4542	1	0.73752	1	0.17271	1	0.49598	1	0.77563	1	NA	NA	NA	NA
ZPBP	5 (2%)	279	0.16583	1	0.28716	1	0.092869	1	0.4542	1	0.22966	1	NA	NA	NA	NA	NA	NA	0.60927	1	1	1
PSPH	5 (2%)	279	0.32928	1	0.53306	1	0.86855	1	0.46195	1	0.01378	1	0.10644	1	0.093028	1	0.5881	1	1	1	0.53567	1
UGT2A3	6 (2%)	278	1	1	0.53306	1	0.76249	1	0.46195	1	0.6734	1	0.78796	1	0.57524	1	0.53203	1	NA	NA	NA	NA
WNT2	5 (2%)	279	0.020896	1	0.00332	1	1	1	0.78908	1	1	1	NA	NA	0.041607	1	0.42317	1	NA	NA	NA	NA
OR5D18	6 (2%)	278	0.21677	1	1	1	0.47495	1	0.55544	1	0.51494	1	0.53097	1	0.72822	1	0.53203	1	1	1	0.7639	1
OR5W2	5 (2%)	279	0.31224	1	0.18359	1	0.32757	1	0.61691	1	1	1	NA	NA	0.43928	1	0.19537	1	NA	NA	NA	NA
ABCB1	10 (4%)	274	0.63985	1	0.087298	1	0.30861	1	0.22994	1	0.43497	1	0.61252	1	0.93135	1	0.8515	1	1	1	0.082762	1
COL1A2	11 (4%)	273	0.6656	1	0.33314	1	0.44653	1	0.81701	1	0.85945	1	0.82947	1	0.4888	1	1	1	0.85517	1	0.012603	1
ATRX	16 (6%)	268	0.00022653	0.192	0.000201	0.171	0.004549	1	0.0001374	0.117	6.2333e-05	0.0532	0.15516	1	0.00605	1	0.012055	1	0.001948	1	0.042104	1
C1ORF150	3 (1%)	281	NA	NA	NA	NA	NA	NA	NA	NA	0.37911	1	0.61252	1	0.89226	1	0.77563	1	NA	NA	NA	NA
LRRC55	6 (2%)	278	0.32928	1	0.4495	1	0.53892	1	0.14314	1	0.32787	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
DCAF12L2	8 (3%)	276	0.86805	1	1	1	0.63116	1	0.67941	1	0.31078	1	0.69734	1	0.58255	1	1	1	0.46645	1	1	1
LRFN5	7 (2%)	277	0.89633	1	0.61868	1	0.42583	1	1	1	1	1	0.81661	1	0.29172	1	0.43406	1	1	1	0.8479	1
LUM	5 (2%)	279	0.31224	1	0.47377	1	0.50734	1	1	1	0.32972	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
MMP13	6 (2%)	278	0.74279	1	0.72619	1	0.5041	1	0.45211	1	0.88026	1	NA	NA	0.20431	1	0.19537	1	0.33629	1	0.37041	1
HEATR7B2	11 (4%)	273	0.13506	1	0.71245	1	0.34413	1	0.3422	1	0.59356	1	0.35484	1	0.34575	1	0.8515	1	0.72044	1	1	1
UGT2B28	6 (2%)	278	1	1	0.66998	1	1	1	0.25194	1	0.51494	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
OR5D13	5 (2%)	279	0.076692	1	1	1	0.29107	1	0.83127	1	0.32972	1	NA	NA	0.43928	1	0.078076	1	NA	NA	NA	NA
ZNF99	6 (2%)	278	1	1	0.82139	1	0.38234	1	0.61691	1	0.38531	1	0.40205	1	0.24636	1	0.30039	1	NA	NA	NA	NA
SLC5A7	7 (2%)	277	0.10225	1	0.2044	1	0.35242	1	0.83127	1	0.38531	1	0.76484	1	0.68197	1	0.27712	1	NA	NA	NA	NA
SEMA3E	8 (3%)	276	0.16616	1	0.17058	1	0.5041	1	0.37009	1	0.81928	1	0.052852	1	0.0094197	1	0.040845	1	0.33629	1	0.058013	1
TCHH	16 (6%)	268	0.27432	1	0.1307	1	0.42963	1	0.13674	1	0.44579	1	0.35416	1	0.52478	1	0.59277	1	0.32221	1	0.13507	1
SLC26A3	7 (2%)	277	0.44963	1	0.87422	1	0.55386	1	0.87821	1	0.80089	1	NA	NA	0.16728	1	0.010445	1	0.15631	1	0.16282	1
GABRB2	6 (2%)	278	0.69328	1	0.094365	1	0.1109	1	1	1	0.11155	1	0.15285	1	0.020853	1	0.30039	1	0.57192	1	0.11955	1
CFHR4	5 (2%)	279	0.74279	1	0.85305	1	0.8278	1	0.67941	1	0.52407	1	NA	NA	0.41095	1	1	1	0.60927	1	1	1
IL18RAP	6 (2%)	278	0.32928	1	0.059516	1	0.22686	1	0.1208	1	0.88026	1	0.13828	1	0.53186	1	0.67306	1	0.46454	1	0.7639	1
OGDH	3 (1%)	281	1	1	0.79163	1	NA	NA	NA	NA	1	1	NA	NA	NA	NA	NA	NA	0.79121	1	0.28637	1
PCDH11X	9 (3%)	275	0.54382	1	0.53314	1	0.17167	1	0.035392	1	0.11632	1	NA	NA	0.025052	1	0.020325	1	0.66253	1	0.31191	1
SPRYD5	6 (2%)	278	0.8742	1	1	1	0.21374	1	0.51059	1	0.58641	1	NA	NA	1	1	0.43406	1	0.52315	1	0.70545	1
TGFA	4 (1%)	280	NA	NA	NA	NA	NA	NA	NA	NA	0.68821	1	NA	NA	1	1	0.43406	1	NA	NA	NA	NA
OR5P2	4 (1%)	280	0.65173	1	0.79163	1	0.38234	1	1	1	0.19295	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
UGT2B4	5 (2%)	279	0.030513	1	0.26035	1	0.32757	1	0.78908	1	0.52407	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
FOXR2	5 (2%)	279	1	1	0.68481	1	0.75418	1	0.038513	1	0.38962	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
PSG8	6 (2%)	278	1	1	1	1	0.8278	1	0.36352	1	0.6734	1	0.78796	1	0.70315	1	1	1	0.72044	1	0.8479	1
CNTNAP2	13 (5%)	271	0.81519	1	0.55338	1	0.16968	1	0.51381	1	0.75636	1	0.67615	1	0.86141	1	0.71348	1	0.68531	1	1	1
PIK3C2G	9 (3%)	275	0.22583	1	0.035493	1	0.89057	1	0.57656	1	0.26622	1	0.70271	1	0.76143	1	0.70945	1	NA	NA	NA	NA
SCN9A	11 (4%)	273	0.68557	1	0.49813	1	0.96325	1	0.30961	1	0.68724	1	NA	NA	0.76143	1	0.8515	1	0.52315	1	0.70545	1
GABRA1	6 (2%)	278	0.20219	1	0.72619	1	0.70337	1	0.37009	1	0.88026	1	NA	NA	0.43928	1	0.19537	1	1	1	0.80154	1
DYNC1I1	7 (2%)	277	0.37731	1	0.044102	1	0.47019	1	0.21209	1	1	1	NA	NA	0.14749	1	0.82051	1	NA	NA	NA	NA
PODXL	3 (1%)	281	1	1	1	1	0.50734	1	0.78908	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
HCN1	11 (4%)	273	0.92242	1	0.92142	1	0.13409	1	0.043538	1	0.68724	1	0.95342	1	NA	NA	NA	NA	1	1	0.53567	1
POTEF	5 (2%)	279	0.030513	1	0.79163	1	1	1	0.78908	1	0.070948	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
CXORF22	8 (3%)	276	0.3075	1	0.79518	1	0.1109	1	1	1	0.38531	1	0.50646	1	0.58061	1	0.57358	1	0.57192	1	0.80154	1
AFM	6 (2%)	278	1	1	0.53306	1	0.8085	1	0.45211	1	0.51494	1	NA	NA	0.79104	1	0.5881	1	NA	NA	NA	NA
KRTAP20-2	3 (1%)	281	0.31224	1	0.79163	1	1	1	0.61691	1	0.28098	1	NA	NA	0.43928	1	0.078076	1	NA	NA	NA	NA
OTC	3 (1%)	281	0.41739	1	0.79163	1	NA	NA	NA	NA	0.19383	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
TRAT1	4 (1%)	280	0.46909	1	0.68481	1	0.76249	1	0.78908	1	0.82714	1	NA	NA	NA	NA	NA	NA	0.25359	1	0.7639	1
KLK6	4 (1%)	280	NA	NA	NA	NA	NA	NA	NA	NA	0.00654	1	NA	NA	1	1	0.43406	1	NA	NA	NA	NA
OR4D5	4 (1%)	280	0.27153	1	0.46484	1	0.35242	1	1	1	0.31332	1	NA	NA	NA	NA	NA	NA	0.46645	1	0.16282	1
GPX5	3 (1%)	281	0.77569	1	0.33925	1	NA	NA	NA	NA	0.49825	1	NA	NA	0.093028	1	0.5881	1	1	1	0.53567	1
KRTAP4-7	3 (1%)	281	0.208	1	0.26035	1	NA	NA	NA	NA	0.37911	1	NA	NA	0.29172	1	0.43406	1	NA	NA	NA	NA
CDH9	8 (3%)	276	0.40216	1	0.1286	1	0.6156	1	0.57656	1	0.80089	1	NA	NA	0.33525	1	0.24677	1	0.26123	1	0.2329	1
CDHR3	3 (1%)	281	0.41739	1	1	1	NA	NA	NA	NA	0.19383	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
OR4P4	4 (1%)	280	NA	NA	NA	NA	NA	NA	NA	NA	0.19295	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
OR52M1	4 (1%)	280	0.46909	1	1	1	0.18345	1	0.058688	1	0.10595	1	NA	NA	NA	NA	NA	NA	1	1	0.7639	1
KLF17	5 (2%)	279	0.62498	1	0.4495	1	0.63116	1	0.83127	1	0.73752	1	NA	NA	0.78517	1	0.67306	1	NA	NA	NA	NA
OR8J3	4 (1%)	280	0.69275	1	0.82139	1	0.29107	1	0.17383	1	0.19383	1	NA	NA	0.49598	1	0.43406	1	NA	NA	NA	NA
AP3S1	3 (1%)	281	0.53397	1	1	1	0.58921	1	1	1	0.63286	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
ST6GAL2	6 (2%)	278	1	1	0.87422	1	0.37401	1	0.87821	1	0.86236	1	NA	NA	NA	NA	NA	NA	0.20836	1	0.16282	1
CD3EAP	3 (1%)	281	1	1	0.79163	1	1	1	0.61691	1	1	1	NA	NA	NA	NA	NA	NA	0.60927	1	1	1
F9	4 (1%)	280	0.77569	1	1	1	0.14419	1	0.18329	1	1	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
DPP10	7 (2%)	277	0.70647	1	0.1286	1	0.26698	1	0.65775	1	0.88026	1	NA	NA	0.64653	1	0.16817	1	0.60927	1	1	1
TCN1	4 (1%)	280	0.69275	1	0.56675	1	0.67286	1	0.1208	1	0.39063	1	0.052852	1	NA	NA	NA	NA	0.33629	1	0.37041	1
TRPV6	7 (2%)	277	0.8742	1	0.76587	1	0.23806	1	0.33762	1	0.6734	1	NA	NA	0.16436	1	0.5881	1	0.094082	1	0.46468	1
PAN3	6 (2%)	278	0.86805	1	0.61692	1	0.53892	1	0.63399	1	0.77179	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
CDKN2C	3 (1%)	281	0.65173	1	0.79163	1	0.67286	1	0.61691	1	0.7811	1	NA	NA	NA	NA	NA	NA	0.46454	1	0.28637	1
AZGP1	5 (2%)	279	0.86805	1	0.61692	1	0.10875	1	0.17383	1	1	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
DRD5	7 (2%)	277	0.89633	1	0.61868	1	0.5955	1	0.38467	1	0.43255	1	NA	NA	0.37371	1	0.53203	1	0.79121	1	1	1
FGA	6 (2%)	278	0.24082	1	0.61692	1	0.08088	1	0.064722	1	1	1	NA	NA	NA	NA	NA	NA	0.46454	1	0.7639	1
FGG	5 (2%)	279	0.21677	1	0.28716	1	NA	NA	NA	NA	0.73752	1	1	1	0.20905	1	0.32478	1	NA	NA	NA	NA
OR10G8	4 (1%)	280	0.84166	1	1	1	0.86855	1	1	1	0.82714	1	NA	NA	0.70315	1	1	1	NA	NA	NA	NA
PCMTD1	3 (1%)	281	1	1	0.79163	1	NA	NA	NA	NA	0.7811	1	NA	NA	0.79104	1	0.5881	1	NA	NA	NA	NA
PROKR2	6 (2%)	278	0.53256	1	0.21129	1	0.86399	1	0.84738	1	0.11155	1	NA	NA	NA	NA	NA	NA	0.20918	1	0.2329	1
SHB	3 (1%)	281	0.31224	1	0.47377	1	NA	NA	NA	NA	1	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
CYP3A5	5 (2%)	279	1	1	0.47377	1	NA	NA	NA	NA	0.86236	1	0.76484	1	0.62168	1	0.13194	1	0.60927	1	1	1
FRMD7	6 (2%)	278	0.69275	1	1	1	0.67286	1	0.78908	1	0.44872	1	0.40205	1	0.41095	1	0.67306	1	0.79121	1	0.53567	1
KCNB2	6 (2%)	278	0.45088	1	0.31161	1	0.14368	1	0.67941	1	0.18909	1	0.78796	1	0.43928	1	0.078076	1	0.60927	1	1	1
KDR	8 (3%)	276	0.25563	1	0.30379	1	0.13409	1	0.0016981	1	0.39852	1	1	1	0.14385	1	0.8515	1	NA	NA	NA	NA