PARADIGM pathway analysis of mRNA expression and copy number data
Glioblastoma Multiforme (Primary solid tumor)
21 April 2013  |  analyses__2013_04_21
Maintainer Information
Citation Information
doi:10.7908/C1X9287R
Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Cite as Broad Institute TCGA Genome Data Analysis Center (2013): Glioblastoma Multiforme (Primary solid tumor cohort) - 21 April 2013: PARADIGM pathway analysis of mRNA expression and copy number data. Broad Institute of MIT and Harvard. doi:10.7908/C1X9287R
Overview
Introduction

PAthway Representation and Analysis by Direct Inference on Graphical Models (PARADIGM) predicts the activity of a diverse set of molecular concepts such as genes, complexes, and processes. The predicted activities are called Inferred Pathway Levels (IPLs) and are derived from a probabilistic belief propagation strategy that incorporates multimodal data such as copy number and gene expression estimates with a concept's pathway context.

Summary

There were 34 significant pathways identified in this analysis.

Table 1.  Get Full Table Top 10 out of 131 pathways in order of significance.

Pathway.Name Avg.Num.Perturbations
Glypican 2 network 222
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 97
LPA receptor mediated events 75
Endothelins 73
Ceramide signaling pathway 69
amb2 Integrin signaling 66
TCGA08_retinoblastoma 65
TCGA08_p53 60
BARD1 signaling events 58
PLK2 and PLK4 events 52
Results
Summary Table

The following list describes the columns found in Table 2.

  • Pathway.Name = Full pathway name of curated PARADIGM pathway

  • Avg.Num.Perturbations = Average number of samples with perturbations across the pathway concepts determined by a background permutation model (>2 standard deviations away from the permuted distribution)

  • Total.Perturbations = Total number of perturbed concepts across all samples (>2 standard deviations away from the permuted distribution)

  • Num.Entities = Number of concepts that belong to the pathway

  • Min.Mean.Truth = Minimum IPL for concepts in the pathway among real samples

  • Max.Mean.Truth = Maximum IPL for concepts in the pathway among real samples

  • Min.Mean.Within = Minimum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Max.Mean.Within = Maximum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Min.Mean.Any = Minimum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes)

  • Max.Mean.Any = Maximum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes).

Table 2.  Get Full Table This summary table provides a report of cancer type specific pathway perturbations. Click on the links in the first column to display more detailed results for each pathway.

Pathway.Name Avg.Num.Perturbations Total.Perturbations Num.Entities Min.Mean.Truth Max.Mean.Truth Min.Mean.Within Max.Mean.Within Min.Mean.Any Max.Mean.Within.1
Glypican 2 network 222 891 4 -0.022 0 1000 -1000 0 -1000
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 97 6612 68 -0.24 0.065 1000 -1000 -0.04 -1000
LPA receptor mediated events 75 7743 102 -0.038 0.046 1000 -1000 -0.06 -1000
Endothelins 73 7043 96 -0.47 0.032 1000 -1000 -0.042 -1000
Ceramide signaling pathway 69 5248 76 -0.092 0.065 1000 -1000 -0.021 -1000
amb2 Integrin signaling 66 5447 82 -0.043 0.045 1000 -1000 -0.01 -1000
TCGA08_retinoblastoma 65 527 8 -0.073 0.081 1000 -1000 -0.003 -1000
TCGA08_p53 60 425 7 -0.007 0.029 1000 -1000 -0.012 -1000
BARD1 signaling events 58 3344 57 -0.043 0.062 1000 -1000 -0.046 -1000
PLK2 and PLK4 events 52 158 3 -0.016 0.032 1000 -1000 -0.021 -1000
EPO signaling pathway 50 2794 55 -0.005 0.061 1000 -1000 -0.019 -1000
HIF-2-alpha transcription factor network 49 2149 43 -0.075 0.043 1000 -1000 -0.024 -1000
Arf6 signaling events 46 2876 62 0 0.081 1000 -1000 -0.006 -1000
VEGFR1 specific signals 46 2581 56 -0.037 0.052 1000 -1000 -0.022 -1000
HIF-1-alpha transcription factor network 42 3253 76 -0.095 0.035 1000 -1000 -0.031 -1000
Aurora B signaling 42 2818 67 -0.039 0.049 1000 -1000 -0.02 -1000
Osteopontin-mediated events 41 1572 38 -0.083 0.044 1000 -1000 -0.019 -1000
Wnt signaling 39 279 7 0 0.032 1000 -1000 0.002 -1000
Syndecan-4-mediated signaling events 39 2621 67 -0.056 0.032 1000 -1000 -0.03 -1000
Syndecan-1-mediated signaling events 37 1283 34 -0.035 0.032 1000 -1000 -0.015 -1000
Signaling events mediated by Stem cell factor receptor (c-Kit) 37 2913 78 -0.037 0.038 1000 -1000 -0.043 -1000
Ras signaling in the CD4+ TCR pathway 35 609 17 -0.003 0.031 1000 -1000 -0.012 -1000
PLK1 signaling events 32 2795 85 -0.039 0.056 1000 -1000 -0.012 -1000
Signaling events mediated by VEGFR1 and VEGFR2 30 3787 125 -0.047 0.044 1000 -1000 -0.032 -1000
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 30 991 33 -0.059 0.063 1000 -1000 -0.006 -1000
S1P1 pathway 29 1072 36 -0.055 0.035 1000 -1000 -0.016 -1000
FAS signaling pathway (CD95) 29 1374 47 -0.15 0.045 1000 -1000 -0.029 -1000
Caspase cascade in apoptosis 28 2133 74 -0.055 0.054 1000 -1000 -0.029 -1000
PDGFR-alpha signaling pathway 28 1275 44 -0.04 0.049 1000 -1000 -0.023 -1000
HIV-1 Nef: Negative effector of Fas and TNF-alpha 28 1266 45 -0.06 0.054 1000 -1000 -0.021 -1000
Signaling events mediated by the Hedgehog family 27 1411 52 -0.015 0.066 1000 -1000 -0.021 -1000
JNK signaling in the CD4+ TCR pathway 27 461 17 -0.12 0.057 1000 -1000 -0.017 -1000
Glypican 1 network 27 1326 48 -0.031 0.06 1000 -1000 -0.028 -1000
Signaling mediated by p38-alpha and p38-beta 27 1227 44 -0.037 0.059 1000 -1000 -0.015 -1000
Paxillin-independent events mediated by a4b1 and a4b7 26 975 37 -0.048 0.074 1000 -1000 -0.018 -1000
TCGA08_rtk_signaling 26 690 26 -0.044 0.13 1000 -1000 -0.005 -1000
Arf6 trafficking events 26 1890 71 -0.034 0.041 1000 -1000 -0.03 -1000
Plasma membrane estrogen receptor signaling 26 2305 86 -0.43 0.053 1000 -1000 -0.038 -1000
Regulation of cytoplasmic and nuclear SMAD2/3 signaling 25 597 23 -0.021 0.037 1000 -1000 -0.003 -1000
Fc-epsilon receptor I signaling in mast cells 25 2501 97 -0.1 0.056 1000 -1000 -0.051 -1000
Regulation of nuclear SMAD2/3 signaling 24 3377 136 -0.21 0.059 1000 -1000 -0.037 -1000
Integrins in angiogenesis 24 2016 84 -0.048 0.079 1000 -1000 -0.039 -1000
Canonical Wnt signaling pathway 24 1252 51 -0.034 0.11 1000 -1000 -0.02 -1000
IL1-mediated signaling events 23 1478 62 -0.052 0.056 1000 -1000 -0.035 -1000
Signaling events regulated by Ret tyrosine kinase 23 1937 82 -0.043 0.048 1000 -1000 -0.02 -1000
E-cadherin signaling in keratinocytes 23 1011 43 -0.012 0.075 1000 -1000 -0.015 -1000
BMP receptor signaling 22 1839 81 -0.03 0.057 1000 -1000 -0.008 -1000
Signaling events mediated by PTP1B 21 1650 76 -0.026 0.06 1000 -1000 -0.015 -1000
Class I PI3K signaling events mediated by Akt 21 1458 68 -0.026 0.06 1000 -1000 -0.02 -1000
FOXM1 transcription factor network 21 1095 51 -0.19 0.032 1000 -1000 -0.12 -1000
Noncanonical Wnt signaling pathway 20 530 26 -0.022 0.032 1000 -1000 -0.028 -1000
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 20 1750 85 -0.023 0.12 1000 -1000 -0.036 -1000
ceramide signaling pathway 20 990 49 -0.016 0.045 1000 -1000 -0.023 -1000
Visual signal transduction: Cones 19 755 38 -0.02 0.053 1000 -1000 -0.016 -1000
Arf6 downstream pathway 19 847 43 -0.024 0.047 1000 -1000 -0.026 -1000
FOXA2 and FOXA3 transcription factor networks 19 881 46 0 0.09 1000 -1000 -0.065 -1000
IFN-gamma pathway 19 1310 68 -0.056 0.063 1000 -1000 -0.029 -1000
EGFR-dependent Endothelin signaling events 19 411 21 -0.012 0.032 1000 -1000 -0.024 -1000
Aurora A signaling 18 1085 60 -0.034 0.065 1000 -1000 -0.021 -1000
Nectin adhesion pathway 18 1181 63 -0.015 0.075 1000 -1000 -0.041 -1000
TRAIL signaling pathway 18 903 48 -0.034 0.072 1000 -1000 -0.021 -1000
Signaling events mediated by HDAC Class I 18 1956 104 -0.041 0.053 1000 -1000 -0.034 -1000
FoxO family signaling 18 1172 64 -0.093 0.043 1000 -1000 -0.045 -1000
Paxillin-dependent events mediated by a4b1 18 653 36 -0.042 0.046 1000 -1000 -0.036 -1000
TCR signaling in naïve CD8+ T cells 18 1708 93 -0.33 0.38 1000 -1000 -0.026 -1000
E-cadherin signaling in the nascent adherens junction 18 1408 76 -0.036 0.082 1000 -1000 -0.029 -1000
S1P3 pathway 18 771 42 -0.031 0.034 1000 -1000 -0.013 -1000
mTOR signaling pathway 17 951 53 -0.033 0.05 1000 -1000 -0.031 -1000
Signaling events mediated by HDAC Class III 17 711 40 -0.037 0.041 1000 -1000 -0.044 -1000
Role of Calcineurin-dependent NFAT signaling in lymphocytes 17 1460 83 -0.046 0.061 1000 -1000 -0.016 -1000
Regulation of Telomerase 17 1769 102 -0.025 0.075 1000 -1000 -0.027 -1000
BCR signaling pathway 17 1724 99 -0.048 0.051 1000 -1000 -0.033 -1000
Signaling events mediated by PRL 17 610 34 -0.026 0.047 1000 -1000 -0.025 -1000
Coregulation of Androgen receptor activity 16 1287 76 -0.047 0.059 1000 -1000 -0.018 -1000
Retinoic acid receptors-mediated signaling 16 981 58 -0.013 0.057 1000 -1000 -0.029 -1000
IL2 signaling events mediated by PI3K 16 934 58 -0.18 0.042 1000 -1000 -0.03 -1000
Class I PI3K signaling events 16 1229 73 -0.025 0.057 1000 -1000 -0.019 -1000
PDGFR-beta signaling pathway 16 1599 97 -0.043 0.066 1000 -1000 -0.035 -1000
Syndecan-2-mediated signaling events 15 1064 69 -0.021 0.054 1000 -1000 -0.019 -1000
Presenilin action in Notch and Wnt signaling 15 919 61 -0.005 0.071 1000 -1000 -0.032 -1000
Syndecan-3-mediated signaling events 15 534 35 -0.008 0.072 1000 -1000 -0.02 -1000
EPHB forward signaling 15 1330 85 -0.05 0.078 1000 -1000 -0.037 -1000
Lissencephaly gene (LIS1) in neuronal migration and development 14 797 54 -0.02 0.047 1000 -1000 -0.025 -1000
Thromboxane A2 receptor signaling 14 1518 105 -0.035 0.042 1000 -1000 -0.027 -1000
p75(NTR)-mediated signaling 14 1800 125 -0.049 0.072 1000 -1000 -0.037 -1000
Insulin-mediated glucose transport 14 477 32 -0.03 0.042 1000 -1000 -0.021 -1000
IL6-mediated signaling events 14 1071 75 -0.021 0.071 1000 -1000 -0.064 -1000
Sumoylation by RanBP2 regulates transcriptional repression 14 379 27 -0.029 0.07 1000 -1000 -0.023 -1000
E-cadherin signaling events 14 70 5 0.029 0.057 1000 -1000 0.028 -1000
Canonical NF-kappaB pathway 13 530 39 -0.028 0.065 1000 -1000 -0.016 -1000
Hedgehog signaling events mediated by Gli proteins 13 876 65 -0.005 0.053 1000 -1000 -0.02 -1000
Stabilization and expansion of the E-cadherin adherens junction 13 1000 74 -0.22 0.069 1000 -1000 -0.041 -1000
IL2 signaling events mediated by STAT5 13 293 22 -0.018 0.033 1000 -1000 -0.019 -1000
Neurotrophic factor-mediated Trk receptor signaling 13 1666 120 -0.038 0.084 1000 -1000 -0.031 -1000
S1P4 pathway 12 315 25 -0.033 0.039 1000 -1000 -0.009 -1000
Arf1 pathway 12 675 54 -0.063 0.042 1000 -1000 -0.011 -1000
ErbB2/ErbB3 signaling events 11 751 65 -0.034 0.039 1000 -1000 -0.053 -1000
Circadian rhythm pathway 11 259 22 -0.01 0.046 1000 -1000 -0.017 -1000
Regulation of p38-alpha and p38-beta 11 605 54 -0.019 0.043 1000 -1000 -0.028 -1000
Effects of Botulinum toxin 11 311 26 0 0.053 1000 -1000 -0.011 -1000
Cellular roles of Anthrax toxin 10 428 39 -0.028 0.032 1000 -1000 -0.013 -1000
Glucocorticoid receptor regulatory network 10 1150 114 -0.073 0.12 1000 -1000 -0.039 -1000
Nongenotropic Androgen signaling 10 527 52 -0.065 0.055 1000 -1000 -0.018 -1000
Angiopoietin receptor Tie2-mediated signaling 10 941 88 -0.063 0.037 1000 -1000 -0.048 -1000
Nephrin/Neph1 signaling in the kidney podocyte 9 318 34 -0.049 0.091 1000 -1000 -0.041 -1000
IL12-mediated signaling events 9 801 87 -0.067 0.058 1000 -1000 -0.066 -1000
Sphingosine 1-phosphate (S1P) pathway 9 276 28 -0.022 0.034 1000 -1000 -0.02 -1000
S1P5 pathway 9 156 17 -0.033 0.033 1000 -1000 -0.006 -1000
Aurora C signaling 8 61 7 0 0.05 1000 -1000 -0.002 -1000
Atypical NF-kappaB pathway 8 257 31 -0.022 0.039 1000 -1000 -0.021 -1000
Insulin Pathway 8 622 74 -0.041 0.078 1000 -1000 -0.027 -1000
Reelin signaling pathway 7 422 56 -0.016 0.061 1000 -1000 -0.018 -1000
Signaling mediated by p38-gamma and p38-delta 7 105 15 -0.026 0.032 1000 -1000 -0.022 -1000
IL4-mediated signaling events 6 563 91 -0.17 0.069 1000 -1000 -0.14 -1000
Ephrin B reverse signaling 6 293 48 -0.011 0.05 1000 -1000 -0.04 -1000
Calcium signaling in the CD4+ TCR pathway 6 196 31 -0.04 0.034 1000 -1000 -0.016 -1000
IGF1 pathway 6 394 57 -0.037 0.062 1000 -1000 -0.026 -1000
p38 MAPK signaling pathway 6 288 44 0 0.052 1000 -1000 -0.013 -1000
Regulation of Androgen receptor activity 6 445 70 -0.036 0.058 1000 -1000 -0.024 -1000
RXR and RAR heterodimerization with other nuclear receptor 5 280 52 -0.059 0.091 1000 -1000 -0.006 -1000
Signaling events mediated by HDAC Class II 4 369 75 -0.032 0.077 1000 -1000 -0.022 -1000
ErbB4 signaling events 4 330 69 -0.027 0.066 1000 -1000 -0.025 -1000
LPA4-mediated signaling events 3 42 12 -0.018 0.009 1000 -1000 -0.016 -1000
a4b1 and a4b7 Integrin signaling 3 16 5 0.025 0.046 1000 -1000 0.027 -1000
IL27-mediated signaling events 3 172 51 -0.022 0.056 1000 -1000 -0.044 -1000
IL23-mediated signaling events 3 189 60 -0.02 0.057 1000 -1000 -0.098 -1000
Rapid glucocorticoid signaling 3 60 20 -0.011 0.032 1000 -1000 -0.011 -1000
Visual signal transduction: Rods 2 148 52 -0.034 0.074 1000 -1000 -0.024 -1000
Alternative NF-kappaB pathway 1 18 13 0 0.054 1000 -1000 0 -1000
Ephrin A reverse signaling 0 3 7 -0.02 0.043 1000 -1000 -0.015 -1000
Class IB PI3K non-lipid kinase events 0 0 3 -0.032 0.032 1000 -1000 -0.027 -1000
Total 3033 167051 7203 -6.7 7.5 131000 -131000 -3.4 -131000
Glypican 2 network

Figure S1.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S1.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MDK -0.022 0.046 -9999 0 -0.063 283 283
GPC2 0 0 -9999 0 -10000 0 0
GPC2/Midkine -0.012 0.03 -9999 0 -0.036 304 304
neuron projection morphogenesis -0.012 0.03 -9999 0 -0.036 304 304
Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Figure S2.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S2.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
FOXP3 0.033 0.007 -10000 0 -0.028 6 6
NFATC2 -0.029 0.096 -10000 0 -0.14 199 199
NFATC3 -0.043 0.11 -10000 0 -0.16 215 215
CD40LG -0.14 0.17 -10000 0 -0.33 206 206
ITCH -0.015 0.009 -10000 0 -10000 0 0
CBLB -0.016 0.008 -10000 0 -0.058 1 1
CD4-positive CD25-positive alpha-beta regulatory T cell lineage commitment -0.13 0.17 -10000 0 -0.38 100 100
JUNB 0.03 0.013 -10000 0 -0.063 8 8
CaM/Ca2+/Calcineurin A alpha-beta B1 0.032 0.019 -10000 0 -0.051 14 14
T cell anergy -0.008 0.027 0.14 3 -0.084 16 19
TLE4 -0.021 0.059 0.097 1 -0.099 111 112
Jun/NFAT1-c-4/p21SNFT -0.1 0.21 -10000 0 -0.33 226 226
AP-1/NFAT1-c-4 -0.12 0.22 -10000 0 -0.35 211 211
IKZF1 -0.014 0.051 0.097 1 -0.09 135 136
T-helper 2 cell differentiation -0.13 0.17 -10000 0 -0.48 66 66
AP-1/NFAT1 -0.02 0.071 -10000 0 -0.11 21 21
CALM1 0.03 0.017 -10000 0 -0.045 14 14
EGR2 -0.092 0.18 -10000 0 -0.34 166 166
EGR3 0.005 0.12 -10000 0 -0.61 18 18
NFAT1/FOXP3 -0.006 0.08 -10000 0 -0.11 93 93
EGR1 0.029 0.017 -10000 0 -0.063 15 15
JUN 0.03 0.012 -10000 0 -0.034 2 2
EGR4 0.033 0.001 -10000 0 -10000 0 0
mol:Ca2+ 0.003 0.006 -10000 0 -10000 0 0
GBP3 -0.02 0.053 0.081 2 -0.082 199 201
FOSL1 0.03 0.015 -10000 0 -0.063 12 12
NFAT1-c-4/MAF/IRF4 -0.099 0.22 -10000 0 -0.33 229 229
DGKA -0.021 0.06 0.097 1 -0.09 194 195
CREM 0.025 0.013 -10000 0 -10000 0 0
NFAT1-c-4/PPARG -0.11 0.22 -10000 0 -0.34 229 229
CTLA4 -0.023 0.054 0.082 1 -0.088 113 114
NFAT1-c-4 (dimer)/EGR1 -0.11 0.22 -10000 0 -0.34 230 230
NFAT1-c-4 (dimer)/EGR4 -0.11 0.22 -10000 0 -0.34 232 232
FOS 0.006 0.041 -10000 0 -0.064 122 122
IFNG -0.05 0.094 -10000 0 -0.26 34 34
T cell activation -0.079 0.11 -10000 0 -10000 0 0
MAF 0.032 0.006 -10000 0 -10000 0 0
T-helper 2 cell lineage commitment 0 0 -10000 0 -10000 0 0
activation-induced cell death of T cells 0.065 0.17 0.32 145 -10000 0 145
TNF -0.13 0.19 -10000 0 -0.33 233 233
FASLG -0.24 0.29 -10000 0 -0.53 241 241
TBX21 0.034 0.005 -10000 0 -0.041 1 1
BATF3 0 0 -10000 0 -10000 0 0
PRKCQ 0.025 0.015 -10000 0 -10000 0 0
PTPN1 -0.021 0.059 0.097 1 -0.096 126 127
NFAT1-c-4/ICER1 -0.12 0.21 -10000 0 -0.35 232 232
GATA3 0.025 0.016 -10000 0 -0.062 2 2
T-helper 1 cell differentiation -0.05 0.093 -10000 0 -0.28 25 25
IL2RA -0.12 0.18 -10000 0 -0.38 107 107
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
CASP3 -0.032 0.064 0.097 1 -0.095 215 216
E2F1 -0.019 0.04 -10000 0 -0.053 225 225
PPARG 0.031 0.009 -10000 0 -0.063 4 4
SLC3A2 -0.022 0.061 0.097 1 -0.095 157 158
IRF4 0.032 0.006 -10000 0 -0.062 1 1
PTGS2 -0.14 0.17 -10000 0 -0.33 204 204
CSF2 -0.14 0.17 0.26 1 -0.33 206 207
JunB/Fra1/NFAT1-c-4 -0.1 0.22 -10000 0 -0.33 227 227
IL4 -0.13 0.18 -10000 0 -0.5 66 66
IL5 -0.14 0.17 -10000 0 -0.33 204 204
IL2 -0.08 0.11 -10000 0 -10000 0 0
IL3 -0.009 0.072 -10000 0 -0.54 6 6
RNF128 -0.017 0.012 -10000 0 -0.079 14 14
NFATC1 -0.052 0.16 -10000 0 -0.33 123 123
CDK4 0.011 0.11 0.27 66 -10000 0 66
PTPRK -0.02 0.059 0.097 1 -0.096 125 126
IL8 -0.15 0.17 -10000 0 -0.33 206 206
POU2F1 0.035 0.005 -10000 0 -10000 0 0
LPA receptor mediated events

Figure S3.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S3.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GNB1/GNG2 -0.006 0.029 -10000 0 -0.034 258 258
NF kappa B1 p50/RelA/I kappa B alpha -0.007 0.062 0.22 6 -0.18 28 34
AP1 -0.017 0.03 -10000 0 -0.04 293 293
mol:PIP3 -0.013 0.018 -10000 0 -0.056 13 13
AKT1 0.008 0.071 0.21 18 -0.24 7 25
PTK2B -0.009 0.027 0.11 2 -0.2 6 8
RHOA 0.011 0.061 0.14 13 -0.3 10 23
PIK3CB 0.031 0.006 -10000 0 -0.031 2 2
mol:Ca2+ -0.012 0.022 0.2 3 -0.12 7 10
MAGI3 0 0 -10000 0 -0.004 3 3
RELA 0.032 0.004 -10000 0 -10000 0 0
apoptosis -0.015 0.026 -10000 0 -0.037 273 273
HRAS/GDP 0.023 0.005 -10000 0 -10000 0 0
positive regulation of microtubule depolymerization -0.011 0.039 0.16 13 -0.19 6 19
NF kappa B1 p50/RelA -0.038 0.02 -10000 0 -0.11 11 11
endothelial cell migration -0.025 0.041 -10000 0 -0.067 242 242
ADCY4 -0.001 0.007 -10000 0 -0.092 1 1
ADCY5 -0.001 0.007 -10000 0 -0.092 1 1
ADCY6 -0.001 0.01 0.086 2 -0.1 2 4
ADCY7 -0.001 0.01 0.086 3 -0.079 2 5
ADCY1 -0.001 0.007 -10000 0 -0.079 2 2
ADCY2 -0.001 0.01 0.086 3 -0.089 1 4
ADCY3 -0.001 0.007 -10000 0 -0.092 1 1
ADCY8 -0.001 0.009 0.086 2 -0.089 1 3
ADCY9 -0.001 0.01 0.086 3 -0.089 1 4
GSK3B -0.012 0.033 0.17 6 -0.19 6 12
arachidonic acid secretion -0.002 0.014 0.077 3 -0.11 5 8
GNG2 0 0.001 -10000 0 -0.004 27 27
TRIP6 -0.008 0.025 -10000 0 -0.041 167 167
GNAO1 0 0.008 -10000 0 -0.039 16 16
HRAS 0.031 0.007 -10000 0 -10000 0 0
NFKBIA -0.022 0.052 0.18 9 -0.18 28 37
GAB1 0.032 0.008 -10000 0 -0.063 3 3
mol:GTP 0 0 -10000 0 -10000 0 0
lamellipodium assembly 0.002 0.17 -10000 0 -0.74 21 21
JUN 0.032 0.005 -10000 0 -10000 0 0
LPA/LPA2/NHERF2 0.002 0.022 -10000 0 -0.021 243 243
TIAM1 -0.003 0.2 -10000 0 -0.84 27 27
PIK3R1 0.03 0.01 -10000 0 -0.032 1 1
mol:IP3 -0.012 0.016 0.17 2 -0.12 2 4
PLCB3 -0.019 0.018 0.18 4 -10000 0 4
FOS 0.007 0.04 -10000 0 -0.063 120 120
positive regulation of mitosis -0.002 0.014 0.077 3 -0.11 5 8
LPA/LPA1-2-3 -0.011 0.015 -10000 0 -0.027 247 247
mol:Ca ++ 0 0 -10000 0 -10000 0 0
JNK cascade 0 0 -10000 0 -10000 0 0
BCAR1 0 0 -10000 0 -10000 0 0
stress fiber formation 0.004 0.023 0.13 1 -10000 0 1
GNAZ -0.01 0.024 -10000 0 -0.039 203 203
EGFR/PI3K-beta/Gab1 -0.013 0.019 0.023 2 -0.063 7 9
positive regulation of dendritic cell cytokine production -0.011 0.015 -10000 0 -0.027 247 247
LPA/LPA2/MAGI-3 -0.005 0.007 -10000 0 -0.012 250 250
ARHGEF1 0.026 0.093 0.17 140 -10000 0 140
GNAI2 -0.013 0.026 -10000 0 -0.039 240 240
GNAI3 -0.016 0.027 -10000 0 -0.041 269 269
GNAI1 -0.008 0.021 -10000 0 -0.039 154 154
LPA/LPA3 -0.007 0.008 -10000 0 -0.015 247 247
LPA/LPA2 -0.007 0.008 -10000 0 -0.015 247 247
LPA/LPA1 -0.016 0.021 -10000 0 -0.038 248 248
HB-EGF/EGFR -0.001 0.024 -10000 0 -0.048 83 83
HBEGF -0.03 0.016 -10000 0 -0.05 165 165
mol:DAG -0.012 0.016 0.17 2 -0.12 2 4
cAMP biosynthetic process 0.046 0.063 0.14 116 -10000 0 116
NFKB1 0.031 0.009 -10000 0 -0.063 4 4
SRC 0.031 0.008 -10000 0 -10000 0 0
GNB1 0.03 0.008 -10000 0 -10000 0 0
LYN -0.017 0.039 0.18 9 -0.16 1 10
GNAQ -0.001 0.013 -10000 0 -0.015 235 235
LPAR2 0 0.001 -10000 0 -0.004 3 3
LPAR3 0 0 -10000 0 -10000 0 0
LPAR1 -0.012 0.013 -10000 0 -0.025 247 247
IL8 -0.038 0.054 0.2 2 -0.29 4 6
PTK2 -0.006 0.025 -10000 0 -0.032 242 242
Rac1/GDP 0.017 0.011 -10000 0 -10000 0 0
CASP3 -0.015 0.026 -10000 0 -0.037 273 273
EGFR 0.012 0.018 -10000 0 -0.063 6 6
PLCG1 0.002 0.008 -10000 0 -0.039 4 4
PLD2 -0.006 0.025 -10000 0 -0.032 245 245
G12/G13 0.003 0.037 -10000 0 -0.042 174 174
PI3K-beta -0.011 0.041 -10000 0 -0.22 10 10
cell migration -0.002 0.048 -10000 0 -0.22 18 18
SLC9A3R2 0.032 0.004 -10000 0 -10000 0 0
PXN 0.004 0.024 0.13 1 -10000 0 1
HRAS/GTP -0.001 0.012 0.077 3 -0.1 4 7
RAC1 0.023 0.015 -10000 0 -10000 0 0
MMP9 -0.001 0.044 -10000 0 -0.063 165 165
PRKCE 0.032 0.005 -10000 0 -0.027 3 3
PRKCD -0.013 0.037 0.21 10 -0.13 1 11
Gi(beta/gamma) 0 0.014 0.086 3 -0.14 3 6
mol:LPA -0.012 0.013 -10000 0 -0.025 247 247
TRIP6/p130 Cas/FAK1/Paxillin -0.009 0.024 -10000 0 -0.13 3 3
MAPKKK cascade -0.002 0.014 0.077 3 -0.11 5 8
contractile ring contraction involved in cytokinesis 0.013 0.062 0.14 17 -0.29 10 27
mol:GDP 0 0 -10000 0 -10000 0 0
GNA14 -0.001 0.013 -10000 0 -0.015 238 238
GNA15 -0.002 0.014 -10000 0 -0.016 234 234
GNA12 0.023 0.015 -10000 0 -10000 0 0
GNA13 0.032 0.007 -10000 0 -0.063 2 2
MAPT -0.014 0.035 0.2 6 -0.19 6 12
GNA11 -0.001 0.013 -10000 0 -0.015 234 234
Rac1/GTP 0.002 0.18 -10000 0 -0.8 19 19
MMP2 -0.025 0.041 -10000 0 -0.067 242 242
Endothelins

Figure S4.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S4.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
AKT1 -0.066 0.034 -10000 0 -0.11 90 90
PTK2B 0.032 0.005 -10000 0 -10000 0 0
mol:Ca2+ -0.088 0.17 0.36 1 -0.41 97 98
EDN1 -0.036 0.043 -10000 0 -0.061 362 362
EDN3 0.029 0.012 -10000 0 -0.063 3 3
EDN2 0.032 0.006 -10000 0 -0.063 1 1
HRAS/GDP -0.028 0.081 0.24 13 -0.29 15 28
ETA receptor/Endothelin-1/Gq/GTP/PLC beta -0.014 0.04 -10000 0 -0.17 12 12
ADCY4 -0.053 0.024 0.011 1 -0.073 259 260
ADCY5 -0.053 0.024 0.011 1 -0.073 259 260
ADCY6 -0.057 0.033 0.16 3 -10000 0 3
ADCY7 -0.057 0.036 0.16 4 -10000 0 4
ADCY1 -0.043 0.037 0.15 2 -10000 0 2
ADCY2 -0.056 0.036 0.16 4 -10000 0 4
ADCY3 -0.053 0.024 0.011 1 -0.073 259 260
ADCY8 -0.056 0.036 0.16 4 -10000 0 4
ADCY9 -0.057 0.035 0.16 4 -10000 0 4
arachidonic acid secretion -0.048 0.094 0.28 10 -0.32 19 29
ETB receptor/Endothelin-1/Gq/GTP -0.007 0.033 -10000 0 -0.15 15 15
GNAO1 0.003 0.009 -10000 0 -10000 0 0
HRAS 0.031 0.007 -10000 0 -10000 0 0
ETA receptor/Endothelin-1/G12/GTP -0.032 0.054 -10000 0 -0.086 179 179
ETA receptor/Endothelin-1/Gs/GTP -0.038 0.057 -10000 0 -0.08 232 232
mol:GTP 0 0.001 -10000 0 -10000 0 0
COL3A1 -0.088 0.041 -10000 0 -0.12 245 245
EDNRB -0.008 0.036 -10000 0 -0.041 256 256
response to oxidative stress 0 0 -10000 0 -10000 0 0
CYSLTR2 -0.063 0.035 -10000 0 -0.11 87 87
CYSLTR1 -0.06 0.03 0.04 1 -0.077 348 349
SLC9A1 -0.03 0.03 -10000 0 -0.054 245 245
mol:GDP -0.031 0.079 0.22 15 -0.3 15 30
SLC9A3 -0.074 0.19 -10000 0 -0.62 41 41
RAF1 -0.031 0.082 0.26 12 -0.3 15 27
JUN -0.096 0.19 0.35 1 -0.45 93 94
JAK2 -0.063 0.036 -10000 0 -0.11 84 84
mol:IP3 -0.014 0.046 -10000 0 -0.21 14 14
ETA receptor/Endothelin-1 -0.056 0.067 -10000 0 -0.095 356 356
PLCB1 0.03 0.009 -10000 0 -10000 0 0
PLCB2 0.031 0.006 -10000 0 -0.029 1 1
ETA receptor/Endothelin-3 -0.027 0.046 -10000 0 -0.057 340 340
FOS -0.039 0.097 0.32 10 -0.32 16 26
Gai/GDP -0.47 0.17 -10000 0 -0.52 454 454
CRK 0.032 0.005 -10000 0 -10000 0 0
mol:Ca ++ -0.044 0.05 -10000 0 -0.19 20 20
BCAR1 0 0 -10000 0 -10000 0 0
PRKCB1 -0.016 0.046 -10000 0 -0.21 15 15
GNAQ 0.031 0.007 -10000 0 -0.027 2 2
GNAZ 0.027 0.013 -10000 0 -10000 0 0
GNAL 0.032 0.006 -10000 0 -10000 0 0
Gs family/GDP -0.03 0.074 0.21 12 -0.28 13 25
ETA receptor/Endothelin-1/Gq/GTP -0.021 0.036 -10000 0 -0.13 15 15
MAPK14 -0.011 0.035 -10000 0 -0.21 7 7
TRPC6 -0.091 0.18 0.36 1 -0.42 97 98
GNAI2 0.032 0.006 -10000 0 -10000 0 0
GNAI3 0.021 0.03 -10000 0 -0.063 58 58
GNAI1 0.019 0.016 -10000 0 -0.063 1 1
ETB receptor/Endothelin-1/Gq/GTP/PLC beta -0.004 0.038 -10000 0 -0.16 17 17
ETB receptor/Endothelin-2 0.026 0.031 -10000 0 -0.044 63 63
ETB receptor/Endothelin-3 0.024 0.03 -10000 0 -0.045 59 59
ETB receptor/Endothelin-1 -0.031 0.048 -10000 0 -0.066 294 294
MAPK3 -0.034 0.096 0.32 11 -0.35 11 22
MAPK1 -0.042 0.1 0.31 11 -0.34 18 29
Rac1/GDP -0.026 0.06 0.22 3 -0.28 11 14
cAMP biosynthetic process -0.019 0.043 0.17 8 -0.14 2 10
MAPK8 -0.11 0.22 0.37 1 -0.5 110 111
SRC 0.031 0.008 -10000 0 -10000 0 0
ETB receptor/Endothelin-1/Gi/GTP -0.004 0.024 -10000 0 -0.13 15 15
p130Cas/CRK/Src/PYK2 -0.026 0.084 0.28 12 -0.31 13 25
mol:K + 0 0 -10000 0 -10000 0 0
G12/GDP -0.026 0.06 0.22 3 -0.28 11 14
COL1A2 -0.054 0.062 -10000 0 -0.13 187 187
EntrezGene:2778 0 0 -10000 0 -10000 0 0
ETA receptor/Endothelin-2 -0.028 0.047 -10000 0 -0.057 357 357
mol:DAG -0.015 0.046 -10000 0 -0.21 14 14
MAP2K2 -0.035 0.098 0.33 16 -0.32 14 30
MAP2K1 -0.04 0.083 0.26 10 -0.32 14 24
EDNRA -0.047 0.049 -10000 0 -0.073 365 365
positive regulation of muscle contraction -0.009 0.095 0.15 122 -0.12 4 126
Gq family/GDP 0.005 0.08 0.25 3 -0.25 14 17
HRAS/GTP -0.024 0.077 0.22 15 -0.3 16 31
PRKCH -0.02 0.047 0.21 1 -0.26 11 12
RAC1 0.023 0.015 -10000 0 -10000 0 0
PRKCA -0.023 0.053 0.19 2 -0.25 16 18
PRKCB -0.016 0.046 -10000 0 -0.21 15 15
PRKCE -0.024 0.052 -10000 0 -0.25 16 16
PRKCD -0.022 0.05 0.17 2 -0.24 14 16
PRKCG -0.023 0.052 0.21 1 -0.26 15 16
regulation of vascular smooth muscle contraction -0.042 0.11 0.36 9 -0.38 12 21
PRKCQ -0.017 0.041 0.19 3 -0.28 6 9
PLA2G4A -0.05 0.098 0.3 8 -0.34 19 27
GNA14 0.031 0.009 -10000 0 -0.045 4 4
GNA15 0.03 0.013 -10000 0 -0.063 7 7
GNA12 0.023 0.015 -10000 0 -10000 0 0
GNA11 0.031 0.006 -10000 0 -10000 0 0
Rac1/GTP -0.033 0.054 -10000 0 -0.086 183 183
MMP1 0.021 0.045 0.069 110 -0.086 25 135
Ceramide signaling pathway

Figure S5.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S5.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPHK2 -0.015 0.011 0 176 -0.05 2 178
MAP4K4 -0.008 0.038 -10000 0 -0.2 8 8
BAG4 0.032 0.004 -10000 0 -10000 0 0
PKC zeta/ceramide -0.058 0.11 -10000 0 -0.2 158 158
NFKBIA 0.03 0.009 -10000 0 -0.063 1 1
BIRC3 0.026 0.023 -10000 0 -0.063 30 30
BAX -0.027 0.086 -10000 0 -0.36 24 24
RIPK1 0.03 0.013 -10000 0 -0.063 9 9
AKT1 0 0.07 0.75 4 -10000 0 4
BAD -0.064 0.11 0.19 2 -0.21 158 160
SMPD1 -0.006 0.038 0.11 10 -0.17 15 25
RB1 -0.064 0.11 0.2 1 -0.21 158 159
FADD/Caspase 8 -0.002 0.04 -10000 0 -0.25 6 6
MAP2K4 -0.063 0.11 0.19 4 -0.2 150 154
NSMAF 0.032 0.005 -10000 0 -0.063 1 1
response to UV 0 0 -10000 0 -10000 0 0
RAF1 -0.065 0.11 0.18 5 -0.2 155 160
EGF 0.032 0.007 -10000 0 -0.063 2 2
mol:ceramide -0.061 0.12 -10000 0 -0.21 158 158
MADD 0.031 0.006 -10000 0 0 21 21
response to oxidative stress 0 0 -10000 0 -10000 0 0
mol:Free Fatty acid -0.015 0.011 0 168 -0.05 2 170
ASAH1 0.032 0.005 -10000 0 -10000 0 0
negative regulation of cell cycle -0.064 0.11 0.2 1 -0.2 158 159
cell proliferation -0.036 0.1 -10000 0 -0.19 142 142
BID -0.026 0.15 -10000 0 -0.64 27 27
MAP3K1 -0.064 0.11 0.2 1 -0.21 157 158
EIF2A -0.064 0.1 0.18 2 -0.19 157 159
TRADD 0.032 0.004 -10000 0 -10000 0 0
CRADD 0.032 0.004 -10000 0 -10000 0 0
MAPK3 -0.059 0.095 0.19 3 -0.19 144 147
response to heat 0 0 -10000 0 -10000 0 0
MAPK1 -0.067 0.1 0.19 3 -0.21 147 150
Cathepsin D/ceramide -0.046 0.12 -10000 0 -0.21 157 157
FADD -0.006 0.033 -10000 0 -0.24 3 3
KSR1 -0.064 0.11 0.2 1 -0.21 158 159
MAPK8 -0.092 0.15 0.15 3 -0.25 190 193
PRKRA -0.064 0.11 -10000 0 -0.21 157 157
PDGFA 0.022 0.016 -10000 0 -0.063 2 2
TRAF2 0.031 0.006 -10000 0 -10000 0 0
IGF1 0.032 0.009 -10000 0 -0.063 4 4
mol:GD3 0 0 -10000 0 -10000 0 0
ganglioside biosynthetic process -0.061 0.12 -10000 0 -0.21 158 158
CTSD 0.029 0.017 -10000 0 -0.063 15 15
regulation of nitric oxide biosynthetic process 0.046 0.012 -10000 0 -0.049 4 4
response to radiation 0 0 -10000 0 -10000 0 0
ERK1/PKC delta -0.038 0.11 -10000 0 -0.2 142 142
PRKCD 0.032 0.006 -10000 0 -10000 0 0
PRKCZ 0 0 -10000 0 -10000 0 0
mol:GW4869 0 0 -10000 0 -10000 0 0
mol:sphingosine -0.015 0.011 0 168 -0.05 2 170
RelA/NF kappa B1 0.046 0.012 -10000 0 -0.05 4 4
mol:glutathione 0 0 -10000 0 -10000 0 0
PAWR 0.031 0.006 -10000 0 -10000 0 0
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD -0.001 0.039 -10000 0 -0.18 11 11
TNFR1A/BAG4/TNF-alpha 0.025 0.054 -10000 0 -0.048 165 165
mol:Sphingosine-1-phosphate -0.015 0.011 0 176 -0.049 2 178
MAP2K1 -0.066 0.1 0.18 5 -0.2 150 155
mol:C11AG 0 0 -10000 0 -10000 0 0
RELA 0.032 0.004 -10000 0 -10000 0 0
CYCS -0.017 0.064 0.11 3 -0.2 40 43
TNFRSF1A 0 0.044 -10000 0 -0.063 165 165
NFKB1 0.031 0.009 -10000 0 -0.063 4 4
TNFR1A/BAG4 0.014 0.045 -10000 0 -0.05 164 164
EIF2AK2 -0.067 0.11 0.18 2 -0.2 157 159
TNF-alpha/TNFR1A/FAN 0.024 0.054 -10000 0 -0.048 165 165
response to hydrogen peroxide 0 0 -10000 0 -10000 0 0
CASP8 0.02 0.048 -10000 0 -0.29 8 8
MAP2K2 -0.064 0.094 0.17 8 -0.2 149 157
SMPD3 0 0.04 0.1 1 -0.24 9 10
TNF 0.032 0.006 -10000 0 -0.063 2 2
PKC zeta/PAR4 0.023 0.004 -10000 0 -10000 0 0
mol:PHOSPHOCHOLINE -0.035 0.066 0.13 3 -0.13 148 151
NF kappa B1/RelA/I kappa B alpha 0.065 0.035 -10000 0 -10000 0 0
AIFM1 -0.042 0.081 0.11 3 -0.14 153 156
BCL2 0.032 0.006 -10000 0 0 17 17
amb2 Integrin signaling

Figure S6.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S6.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
alphaM/beta2 Integrin/proMMP-2 -0.017 0.057 -10000 0 -0.056 339 339
alphaM/beta2 Integrin/GPIbA 0.016 0.057 -10000 0 -0.049 213 213
alphaM/beta2 Integrin/proMMP-9 -0.005 0.059 -10000 0 -0.057 273 273
PLAUR 0.023 0.027 -10000 0 -0.063 44 44
HMGB1 0.029 0.012 -10000 0 -0.029 11 11
alphaM/beta2 Integrin/Talin 0.007 0.057 -10000 0 -0.051 231 231
AGER 0.03 0.013 -10000 0 -0.039 17 17
RAP1A 0.032 0.004 -10000 0 -10000 0 0
SELPLG 0.032 0.004 -10000 0 -10000 0 0
mol:LDL 0 0 -10000 0 -10000 0 0
alphaM/beta2 Integrin/RAGE/HMGB1 0.017 0.072 -10000 0 -0.083 36 36
mol:GTP 0 0 -10000 0 -10000 0 0
MMP9 -0.001 0.044 -10000 0 -0.063 165 165
CYR61 0.004 0.043 -10000 0 -0.063 150 150
TLN1 0.021 0.027 -10000 0 -0.063 43 43
Rap1/GTP 0.01 0.037 -10000 0 -0.15 4 4
RHOA 0.032 0.006 -10000 0 -10000 0 0
P-selectin oligomer 0.032 0.006 -10000 0 -0.063 1 1
MYH2 0 0.038 0.13 6 -0.16 3 9
MST1R 0.031 0.008 -10000 0 -0.063 2 2
leukocyte activation during inflammatory response 0.012 0.058 -10000 0 -0.055 38 38
APOB 0.032 0.008 -10000 0 -0.063 3 3
mol:GDP 0 0 -10000 0 -10000 0 0
complement component iC3b receptor activity 0 0 -10000 0 -10000 0 0
MMP2 -0.013 0.047 -10000 0 -0.063 241 241
JAM3 0.03 0.009 -10000 0 -0.063 1 1
GP1BA 0.032 0.005 -10000 0 -10000 0 0
alphaM/beta2 Integrin/CTGF 0.008 0.056 -10000 0 -0.051 229 229
alphaM/beta2 Integrin 0.001 0.036 -10000 0 -0.15 6 6
JAM3 homodimer 0.03 0.009 -10000 0 -0.063 1 1
ICAM2 0.032 0.008 -10000 0 -0.063 3 3
ICAM1 0.028 0.018 -10000 0 -0.063 16 16
phagocytosis triggered by activation of immune response cell surface activating receptor 0.001 0.036 -10000 0 -0.14 6 6
cell adhesion 0.016 0.056 -10000 0 -0.049 213 213
NFKB1 -0.041 0.037 0.21 7 -10000 0 7
THY1 0.024 0.015 -10000 0 -10000 0 0
RhoA/GDP 0.023 0.004 -10000 0 -10000 0 0
Lipoprotein(a) 0.04 0.014 -10000 0 -0.042 3 3
alphaM/beta2 Integrin/LRP/tPA -0.011 0.065 -10000 0 -0.069 134 134
IL6 -0.033 0.037 0.16 4 -0.15 2 6
ITGB2 -0.008 0.047 -10000 0 -0.063 214 214
elevation of cytosolic calcium ion concentration -0.009 0.064 -10000 0 -0.075 105 105
alphaM/beta2 Integrin/JAM2/JAM3 0.009 0.066 -10000 0 -0.069 30 30
JAM2 0.018 0.033 -10000 0 -0.063 72 72
alphaM/beta2 Integrin/ICAM1 0.024 0.074 -10000 0 -0.08 5 5
alphaM/beta2 Integrin/uPA/Plg -0.008 0.064 -10000 0 -0.068 110 110
RhoA/GTP 0.005 0.037 0.1 16 -0.13 9 25
positive regulation of phagocytosis -0.002 0.052 0.14 7 -0.14 6 13
Ron/MSP 0.045 0.015 -10000 0 -0.05 8 8
alphaM/beta2 Integrin/uPAR/uPA -0.008 0.065 -10000 0 -0.075 105 105
alphaM/beta2 Integrin/uPAR 0.012 0.058 -10000 0 -0.053 214 214
PLAU 0.007 0.036 -10000 0 -0.063 94 94
PLAT -0.011 0.047 -10000 0 -0.063 233 233
actin filament polymerization 0.001 0.039 0.15 7 -0.16 3 10
MST1 0.031 0.012 -10000 0 -0.063 6 6
alphaM/beta2 Integrin/lipoprotein(a) 0.016 0.061 -10000 0 -0.055 33 33
TNF -0.043 0.035 0.19 7 -10000 0 7
RAP1B 0 0 -10000 0 -10000 0 0
alphaM/beta2 Integrin/uPA -0.004 0.055 -10000 0 -0.057 233 233
fibrinolysis -0.009 0.063 -10000 0 -0.068 110 110
HCK 0.014 0.036 -10000 0 -0.063 85 85
dendritic cell antigen processing and presentation 0.001 0.036 -10000 0 -0.14 6 6
VTN 0.032 0.007 -10000 0 -0.063 2 2
alphaM/beta2 Integrin/CYR61 0 0.061 -10000 0 -0.056 267 267
LPA 0.03 0.008 -10000 0 -10000 0 0
LRP1 0.029 0.016 -10000 0 -0.063 13 13
cell migration -0.032 0.05 -10000 0 -0.064 339 339
FN1 0.014 0.037 -10000 0 -0.063 96 96
alphaM/beta2 Integrin/Thy1 0.007 0.049 -10000 0 -0.049 178 178
MPO 0.032 0.004 -10000 0 -10000 0 0
KNG1 0.032 0.006 -10000 0 -10000 0 0
RAP1/GDP 0.022 0.003 -10000 0 -10000 0 0
ROCK1 0.001 0.043 0.17 10 -0.16 3 13
ELA2 0 0 -10000 0 -10000 0 0
PLG 0.03 0.008 -10000 0 -10000 0 0
CTGF 0.023 0.025 -10000 0 -0.063 36 36
alphaM/beta2 Integrin/Hck 0.01 0.06 -10000 0 -0.058 208 208
ITGAM 0.031 0.01 -10000 0 -0.03 13 13
alphaM/beta2 Integrin/P-Selectin/PSGL1 0.024 0.066 -10000 0 -0.06 34 34
HP 0.017 0.034 -10000 0 -0.063 77 77
leukocyte adhesion -0.008 0.055 -10000 0 -0.11 7 7
SELP 0.032 0.006 -10000 0 -0.063 1 1
TCGA08_retinoblastoma

Figure S7.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S7.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDKN2B 0.011 0.019 -10000 0 -0.036 7 7
CDKN2C -0.006 0.028 -10000 0 -0.053 106 106
CDKN2A 0.006 0.025 -10000 0 -0.049 52 52
CCND2 0.002 0.009 0.079 2 -10000 0 2
RB1 -0.073 0.1 0.1 1 -0.22 169 170
CDK4 0.002 0.01 0.09 2 -10000 0 2
CDK6 0.004 0.016 0.11 6 -10000 0 6
G1/S progression 0.081 0.11 0.22 181 -0.1 1 182
TCGA08_p53

Figure S8.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S8.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDKN2A -0.007 0.012 0 313 -0.039 52 365
TP53 -0.002 0.022 -10000 0 -0.2 5 5
Senescence -0.002 0.024 -10000 0 -0.2 6 6
Apoptosis -0.002 0.024 -10000 0 -0.2 6 6
Activated_Oncogenes 0 0 -10000 0 -10000 0 0
MDM2 -0.001 0.009 0.022 43 -10000 0 43
MDM4 0.029 0.011 -10000 0 -10000 0 0
BARD1 signaling events

Figure S9.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S9.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BARD1/CSTF1 0.023 0.041 -10000 0 -0.05 114 114
ATM 0.027 0.021 -10000 0 -0.063 25 25
UBE2D3 0.032 0.005 -10000 0 -10000 0 0
PRKDC 0.028 0.019 -10000 0 -0.063 21 21
ATR 0.032 0.005 -10000 0 -10000 0 0
UBE2L3 0.031 0.007 -10000 0 -10000 0 0
FANCD2 0.01 0.011 -10000 0 -0.036 25 25
protein ubiquitination 0.043 0.065 -10000 0 -0.078 25 25
XRCC5 0.032 0.002 -10000 0 -10000 0 0
XRCC6 0.03 0.009 -10000 0 -10000 0 0
M/R/N Complex 0.062 0.019 -10000 0 -0.044 1 1
MRE11A 0.032 0.005 -10000 0 -10000 0 0
DNA-PK 0.054 0.034 -10000 0 -0.05 22 22
FA complex/FANCD2/Ubiquitin -0.005 0.08 -10000 0 -0.25 37 37
FANCF 0.031 0.008 -10000 0 -0.063 2 2
BRCA1 0.031 0.01 -10000 0 -0.063 5 5
CCNE1 0.03 0.011 -10000 0 -0.008 32 32
CDK2/Cyclin E1 0.04 0.024 -10000 0 -0.053 23 23
FANCG 0.019 0.03 -10000 0 -0.063 57 57
BRCA1/BACH1/BARD1 0.024 0.042 -10000 0 -0.05 120 120
FANCE 0.032 0.005 -10000 0 -0.063 1 1
FANCC 0.032 0.006 -10000 0 -10000 0 0
NBN 0.032 0.004 -10000 0 -10000 0 0
FANCA 0.031 0.006 -10000 0 -10000 0 0
DNA repair -0.029 0.066 0.18 14 -0.22 25 39
BRCA1/BARD1/ubiquitin 0.024 0.042 -10000 0 -0.05 120 120
BARD1/DNA-PK 0.042 0.062 -10000 0 -0.064 25 25
FANCL 0 0 -10000 0 -10000 0 0
mRNA polyadenylation -0.022 0.041 0.049 114 -10000 0 114
BRCA1/BARD1/CTIP/M/R/N Complex -0.018 0.042 0.1 5 -0.18 16 21
BRCA1/BACH1/BARD1/TopBP1 0.036 0.05 -10000 0 -0.049 122 122
BRCA1/BARD1/P53 0.036 0.065 -10000 0 -0.07 32 32
BARD1/CSTF1/BRCA1 0.035 0.049 -10000 0 -0.049 116 116
BRCA1/BACH1 0.031 0.01 -10000 0 -0.063 5 5
BARD1 0.01 0.041 -10000 0 -0.063 122 122
PCNA -0.026 0.045 -10000 0 -0.063 299 299
BRCA1/BARD1/UbcH5C 0.036 0.05 -10000 0 -0.049 123 123
BRCA1/BARD1/UbcH7 0.035 0.051 -10000 0 -0.05 122 122
BRCA1/BARD1/RAD51/PCNA -0.01 0.064 -10000 0 -0.069 104 104
BARD1/DNA-PK/P53 0.038 0.075 -10000 0 -0.076 35 35
BRCA1/BARD1/Ubiquitin 0.024 0.042 -10000 0 -0.05 120 120
BRCA1/BARD1/CTIP -0.034 0.044 -10000 0 -0.057 392 392
FA complex 0.012 0.034 0.088 8 -0.15 16 24
BARD1/EWS 0.024 0.04 -10000 0 -0.05 107 107
RBBP8 -0.043 0.016 -10000 0 -0.051 379 379
TP53 0.019 0.032 -10000 0 -0.063 65 65
TOPBP1 0.032 0.006 -10000 0 -0.063 1 1
G1/S transition of mitotic cell cycle -0.034 0.063 0.07 32 -10000 0 32
BRCA1/BARD1 0.048 0.069 -10000 0 -0.09 10 10
CSTF1 0.03 0.009 -10000 0 0 39 39
BARD1/EWS-Fli1 0.009 0.027 -10000 0 -0.039 122 122
CDK2 0.027 0.021 -10000 0 -0.063 24 24
UniProt:Q9BZD1 0 0 -10000 0 -10000 0 0
RAD51 0.032 0.006 -10000 0 -10000 0 0
RAD50 0.032 0.004 -10000 0 -10000 0 0
BRCA1/BARD1/DNA-directed RNA polymerase II holoenzyme 0.024 0.042 -10000 0 -0.05 120 120
EWSR1 0.03 0.008 -10000 0 -10000 0 0
PLK2 and PLK4 events

Figure S10.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S10.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PLK2 0.023 0.015 -9999 0 -9999 0 0
PLK4 0.032 0.004 -9999 0 -9999 0 0
regulation of centriole replication -0.016 0.01 0 158 -9999 0 158
EPO signaling pathway

Figure S11.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S11.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.036 0.046 0.18 18 -0.16 2 20
CRKL 0.026 0.092 0.16 130 -10000 0 130
mol:DAG 0.011 0.028 0.14 4 -0.14 2 6
HRAS 0.019 0.095 0.28 29 -10000 0 29
MAPK8 0.005 0.067 0.15 84 -10000 0 84
RAP1A 0.026 0.09 0.16 136 -10000 0 136
GAB1 0.027 0.093 0.16 135 -10000 0 135
MAPK14 0.02 0.083 0.15 146 -10000 0 146
EPO 0.024 0.016 -10000 0 -10000 0 0
PLCG1 0.011 0.028 0.14 4 -0.14 2 6
EPOR/TRPC2/IP3 Receptors 0.037 0.011 0.084 5 -10000 0 5
RAPGEF1 0.031 0.006 -10000 0 -10000 0 0
EPO/EPOR (dimer)/SOCS3 0.045 0.032 -10000 0 -10000 0 0
GAB1/SHC/GRB2/SOS1 0.013 0.085 0.15 123 -10000 0 123
EPO/EPOR (dimer) 0.034 0.024 -10000 0 -10000 0 0
IRS2 0.027 0.091 0.16 134 -10000 0 134
STAT1 0.012 0.031 0.15 4 -0.14 2 6
STAT5B 0.012 0.03 0.15 4 -0.14 2 6
cell proliferation 0.004 0.073 0.16 88 -10000 0 88
GAB1/SHIP/PIK3R1/SHP2/SHC -0.005 0.065 0.11 117 -10000 0 117
TEC 0.027 0.093 0.16 133 -10000 0 133
SOCS3 0.032 0.004 -10000 0 -10000 0 0
STAT1 (dimer) 0.012 0.031 0.15 4 -0.14 2 6
JAK2 0.034 0.015 0.086 6 -10000 0 6
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
EPO/EPOR (dimer)/JAK2 0.051 0.05 0.23 5 -10000 0 5
EPO/EPOR 0.034 0.024 -10000 0 -10000 0 0
LYN 0.022 0.031 -10000 0 -0.062 60 60
TEC/VAV2 0.005 0.07 0.13 110 -10000 0 110
elevation of cytosolic calcium ion concentration 0.037 0.011 0.084 5 -10000 0 5
SHC1 0.024 0.026 -10000 0 -0.063 40 40
EPO/EPOR (dimer)/LYN 0.035 0.043 -10000 0 -0.052 47 47
mol:IP3 0.011 0.028 0.14 4 -0.14 2 6
PI3K regualtory subunit polypeptide 1/IRS2/SHIP 0.021 0.089 0.16 123 -10000 0 123
SH2B3 0.036 0.016 0.078 3 -0.067 7 10
NFKB1 0.02 0.083 0.15 146 -10000 0 146
EPO/EPOR (dimer)/JAK2/SOCS3 0.012 0.011 0.076 2 -10000 0 2
PTPN6 0.028 0.088 0.16 150 -10000 0 150
TEC/VAV2/GRB2 0.061 0.066 0.16 117 -10000 0 117
EPOR 0.037 0.011 0.084 5 -10000 0 5
INPP5D 0 0 -10000 0 -10000 0 0
mol:GDP 0.012 0.086 0.15 123 -10000 0 123
SOS1 0 0 -10000 0 -10000 0 0
PLCG2 0.03 0.014 -10000 0 -0.063 10 10
CRKL/CBL/C3G 0.059 0.067 0.25 18 -10000 0 18
VAV2 0.024 0.088 0.16 129 -10000 0 129
CBL 0.028 0.093 0.16 136 -10000 0 136
SHC/Grb2/SOS1 0.02 0.036 -10000 0 -10000 0 0
STAT5A 0.012 0.03 0.15 4 -0.14 2 6
GRB2 0.032 0.006 -10000 0 -10000 0 0
STAT5 (dimer) 0.023 0.041 0.18 4 -10000 0 4
LYN/PLCgamma2 0.035 0.034 -10000 0 -0.053 61 61
PTPN11 0.032 0.003 -10000 0 -10000 0 0
BTK 0.028 0.094 0.16 139 -10000 0 139
BCL2 0.035 0.05 0.17 20 -0.19 6 26
HIF-2-alpha transcription factor network

Figure S12.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S12.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MMP14 -0.014 0.17 -10000 0 -0.64 33 33
oxygen homeostasis -0.003 0.003 -10000 0 -10000 0 0
TCEB2 0.032 0.004 -10000 0 -10000 0 0
TCEB1 0.032 0.005 -10000 0 -10000 0 0
VHL/Elongin B/Elongin C/HIF2A -0.024 0.075 -10000 0 -0.16 61 61
EPO -0.031 0.072 -10000 0 -0.21 47 47
FIH (dimer) 0.02 0.017 -10000 0 -0.027 21 21
APEX1 0.025 0.019 -10000 0 -0.03 44 44
SERPINE1 -0.045 0.071 -10000 0 -0.18 68 68
FLT1 -0.015 0.16 -10000 0 -0.61 35 35
ADORA2A -0.067 0.07 0.3 2 -0.17 102 104
germ cell development -0.062 0.068 -10000 0 -0.17 104 104
SLC11A2 -0.065 0.074 -10000 0 -0.18 104 104
BHLHE40 -0.063 0.069 -10000 0 -0.17 104 104
HIF1AN 0.02 0.017 -10000 0 -0.027 21 21
HIF2A/ARNT/SIRT1 -0.03 0.086 0.17 1 -0.16 100 101
ETS1 0.034 0.014 -10000 0 -10000 0 0
CITED2 -0.025 0.16 -10000 0 -0.59 39 39
KDR 0.016 0.076 -10000 0 -0.55 8 8
PGK1 -0.064 0.077 0.42 1 -0.18 104 105
SIRT1 0.025 0.014 -10000 0 -10000 0 0
response to hypoxia 0 0 -10000 0 -10000 0 0
HIF2A/ARNT -0.032 0.11 -10000 0 -0.2 74 74
EPAS1 -0.03 0.048 0.11 1 -0.13 76 77
SP1 0.034 0.006 -10000 0 -0.038 1 1
ABCG2 -0.064 0.077 0.42 1 -0.18 104 105
EFNA1 -0.065 0.075 -10000 0 -0.18 104 104
FXN -0.067 0.065 -10000 0 -0.17 99 99
POU5F1 -0.063 0.069 -10000 0 -0.17 104 104
neuron apoptosis 0.032 0.11 0.2 77 -10000 0 77
EP300 0.03 0.008 -10000 0 -10000 0 0
EGLN3 0.024 0.017 -10000 0 -0.033 33 33
EGLN2 0.027 0.013 -10000 0 -0.027 23 23
EGLN1 0.026 0.015 -10000 0 -0.029 30 30
VHL/Elongin B/Elongin C 0.043 0.008 -10000 0 -10000 0 0
VHL 0 0 -10000 0 -10000 0 0
ARNT 0.027 0.018 -10000 0 -0.029 40 40
SLC2A1 -0.067 0.066 0.18 1 -0.17 104 105
TWIST1 -0.041 0.057 -10000 0 -0.17 52 52
ELK1 0.033 0.012 -10000 0 -0.038 13 13
HIF2A/ARNT/Cbp/p300 -0.024 0.095 0.19 1 -0.17 89 90
VEGFA -0.075 0.083 0.42 1 -0.18 122 123
CREBBP 0.032 0.004 -10000 0 -10000 0 0
Arf6 signaling events

Figure S13.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S13.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CENTA1/KIF3B 0.021 0.004 -10000 0 -0.006 11 11
ARNO/beta Arrestin1-2 0.04 0.017 -10000 0 -0.063 11 11
EGFR 0.012 0.018 -10000 0 -0.063 6 6
EPHA2 0.029 0.015 -10000 0 -0.063 12 12
USP6 0.032 0.005 -10000 0 -10000 0 0
IQSEC1 0.032 0.006 -10000 0 -10000 0 0
EGFR/EGFR/EGF/EGF 0.018 0.025 -10000 0 -0.05 8 8
ARRB2 0.013 0.002 -10000 0 -10000 0 0
mol:GTP 0 0.012 0.1 3 -0.064 6 9
ARRB1 0.032 0.004 -10000 0 -10000 0 0
FBXO8 0 0 -10000 0 -10000 0 0
TSHR 0.03 0.012 -10000 0 -0.063 4 4
EGF 0.032 0.007 -10000 0 -0.063 2 2
somatostatin receptor activity 0 0 0 153 0 14 167
ARAP2 0 0 0 148 0 8 156
mol:GDP 0.06 0.064 0.14 140 -0.15 8 148
mol:PI-3-4-5-P3 0 0 0 143 0 14 157
ITGA2B 0.032 0.003 -10000 0 -10000 0 0
ARF6 0.031 0.008 -10000 0 -10000 0 0
Ephrin A1/EPHA2/NCK1/GIT1 0.067 0.042 -10000 0 -0.072 7 7
ADAP1 0 0 0 87 0 6 93
KIF13B 0.032 0.007 -10000 0 -0.063 2 2
HGF/MET 0.031 0.024 -10000 0 -0.05 3 3
PXN 0.032 0.003 -10000 0 -10000 0 0
ARF6/GTP 0.072 0.088 0.18 145 -0.19 12 157
EGFR/EGFR/EGF/EGF/ARFGEP100 0.023 0.033 -10000 0 -0.045 11 11
ADRB2 0.032 0.006 -10000 0 -0.063 1 1
receptor agonist activity 0 0 0 147 0 12 159
actin filament binding 0 0 0 144 0 15 159
SRC 0.031 0.008 -10000 0 -10000 0 0
ITGB3 0.032 0.003 -10000 0 -10000 0 0
GNAQ 0.032 0.006 -10000 0 -10000 0 0
EFA6/PI-4-5-P2 0 0.001 0.001 156 -0.001 12 168
ARF6/GDP 0.024 0.068 0.14 24 -0.21 27 51
ARF6/GDP/GULP/ACAP1 0.08 0.063 0.16 126 -0.15 7 133
alphaIIb/beta3 Integrin/paxillin/GIT1 0.081 0.017 -10000 0 -10000 0 0
ACAP1 0 0 0 41 -10000 0 41
ACAP2 0 0 0 144 0 10 154
LHCGR/beta Arrestin2 0.028 0.016 -10000 0 -0.079 11 11
EFNA1 0.028 0.019 -10000 0 -0.063 20 20
HGF 0.022 0.016 -10000 0 -0.063 1 1
CYTH3 0 0 0.001 145 0 12 157
CYTH2 0 0.001 0.002 3 -0.003 16 19
NCK1 0.03 0.015 -10000 0 -0.063 11 11
fibronectin binding 0 0 0 140 0 19 159
endosomal lumen acidification 0 0 0 150 0 18 168
microtubule-based process 0 0 -10000 0 0 8 8
GULP1 0.032 0.008 -10000 0 -0.063 3 3
GNAQ/ARNO 0.024 0.006 0.039 5 0 19 24
mol:Phosphatidic acid 0 0 0 144 0 10 154
PIP3-E 0 0 0 80 0 15 95
MET 0.022 0.016 -10000 0 -0.063 2 2
GNA14 0.031 0.009 -10000 0 -0.063 2 2
GNA15 0.03 0.013 -10000 0 -0.016 27 27
GIT1 0.032 0.004 -10000 0 -10000 0 0
mol:PI-4-5-P2 0 0 0.001 152 -0.001 12 164
GNA11 0.031 0.006 -10000 0 -10000 0 0
LHCGR 0.033 0.001 -10000 0 -10000 0 0
AGTR1 0.032 0.008 -10000 0 -0.063 2 2
desensitization of G-protein coupled receptor protein signaling pathway 0.027 0.016 -10000 0 -0.079 11 11
IPCEF1/ARNO 0.014 0.02 -10000 0 -0.029 8 8
alphaIIb/beta3 Integrin 0.048 0.005 -10000 0 -10000 0 0
VEGFR1 specific signals

Figure S14.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S14.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR1 homodimer/VEGFB homodimer 0.027 0.02 -10000 0 -0.045 2 2
VEGFR1 homodimer/NRP1 -0.013 0.005 -10000 0 -10000 0 0
mol:DAG -0.024 0.017 0.18 2 -10000 0 2
VEGFR1 homodimer/NRP1/VEGFR 121 -0.01 0.035 -10000 0 -0.041 282 282
CaM/Ca2+ -0.027 0.019 0.18 2 -10000 0 2
HIF1A 0.035 0.011 -10000 0 -0.061 2 2
GAB1 0.032 0.008 -10000 0 -0.063 3 3
AKT1 -0.023 0.034 0.13 15 -0.19 1 16
PLCG1 -0.024 0.017 0.18 2 -10000 0 2
NOS3 -0.007 0.042 0.18 4 -0.21 14 18
CBL 0.032 0.004 -10000 0 -10000 0 0
mol:NO 0.006 0.055 0.2 3 -0.21 14 17
FLT1 -0.016 0.006 -10000 0 -10000 0 0
PGF 0.027 0.02 -10000 0 -0.063 19 19
VEGFR1 homodimer/NRP2/VEGFR121 -0.007 0.049 -10000 0 -0.049 277 277
CALM1 0.029 0.01 -10000 0 -10000 0 0
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
eNOS/Hsp90 0.022 0.075 0.19 10 -0.22 24 34
endothelial cell proliferation -0.011 0.047 0.12 33 -0.14 20 53
mol:Ca2+ -0.024 0.017 0.18 2 -10000 0 2
MAPK3 -0.035 0.017 0.15 2 -10000 0 2
MAPK1 -0.033 0.019 0.15 2 -10000 0 2
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
PLGF homodimer 0.027 0.02 -10000 0 -0.063 19 19
PRKACA 0.032 0.006 -10000 0 0 17 17
RP11-342D11.1 0 0 -10000 0 -10000 0 0
CAV1 -0.018 0.041 -10000 0 -0.063 218 218
VEGFA homodimer -0.019 0.047 -10000 0 -0.063 274 274
VEGFR1 homodimer/VEGFA homodimer -0.012 0.039 -10000 0 -0.046 278 278
platelet activating factor biosynthetic process -0.037 0.02 0.14 2 -10000 0 2
PI3K 0.044 0.047 0.17 1 -0.077 1 2
PRKCA -0.028 0.018 0.17 2 -10000 0 2
PRKCB -0.022 0.016 0.17 2 -10000 0 2
VEGFR1 homodimer/PLGF homodimer 0.026 0.021 -10000 0 -0.045 21 21
VEGFA -0.019 0.047 -10000 0 -0.063 274 274
VEGFB 0.032 0.004 -10000 0 -10000 0 0
mol:IP3 -0.024 0.017 0.18 2 -10000 0 2
RASA1 -0.027 0.015 0.18 2 -10000 0 2
NRP2 0.032 0.004 -10000 0 -0.063 1 1
VEGFR1 homodimer -0.016 0.006 -10000 0 -10000 0 0
VEGFB homodimer 0.032 0.004 -10000 0 -10000 0 0
NCK1 0.03 0.015 -10000 0 -0.063 11 11
eNOS/Caveolin-1 -0.015 0.051 -10000 0 -0.22 17 17
PTPN11 0.032 0.003 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 0.042 0.046 0.16 1 -0.077 1 2
mol:L-citrulline 0.006 0.055 0.2 3 -0.21 14 17
VEGFR1 homodimer/VEGFA homodimer/CBL/CD2AP -0.008 0.059 -10000 0 -0.076 2 2
VEGFR1 homodimer/VEGFA homodimer/NCK1 -0.008 0.049 -10000 0 -0.049 279 279
CD2AP 0.023 0.028 -10000 0 -0.063 48 48
PI3K/GAB1 0.052 0.055 0.18 1 -10000 0 1
PDPK1 -0.031 0.035 0.15 16 -10000 0 16
VEGFR1 homodimer/VEGFA homodimer/SHP2 -0.006 0.049 -10000 0 -0.049 276 276
mol:NADP 0.006 0.055 0.2 3 -0.21 14 17
HSP90AA1 0.03 0.008 -10000 0 -10000 0 0
ubiquitin-dependent protein catabolic process -0.009 0.058 -10000 0 -0.075 2 2
VEGFR1 homodimer/NRP2 0.027 0.021 -10000 0 -0.037 27 27
HIF-1-alpha transcription factor network

Figure S15.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S15.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PKM2 -0.054 0.17 0.5 10 -0.29 14 24
HDAC7 -0.002 0.002 -10000 0 -10000 0 0
HIF1A/ARNT/Cbp/p300/Src-1 -0.076 0.11 -10000 0 -0.24 72 72
SMAD4 0.009 0.04 -10000 0 -0.063 117 117
ID2 -0.055 0.17 0.49 13 -0.28 17 30
AP1 0.022 0.041 -10000 0 -0.05 117 117
ABCG2 -0.058 0.16 0.49 11 -0.28 18 29
HIF1A -0.013 0.054 0.15 7 -0.087 17 24
TFF3 -0.056 0.16 0.48 14 -0.28 19 33
GATA2 0.031 0.009 -10000 0 -0.027 9 9
AKT1 -0.009 0.055 0.17 6 -0.095 1 7
response to hypoxia -0.018 0.025 0.09 7 -0.067 6 13
MCL1 -0.058 0.16 0.51 8 -0.29 16 24
NDRG1 -0.066 0.15 0.51 5 -0.28 18 23
SERPINE1 -0.052 0.15 0.46 12 -0.28 32 44
FECH -0.05 0.17 0.48 15 -0.28 17 32
FURIN -0.053 0.17 0.5 12 -0.28 18 30
NCOA2 0.033 0.004 -10000 0 -10000 0 0
EP300 0.002 0.055 0.22 13 -0.2 2 15
HMOX1 -0.074 0.16 0.52 7 -0.29 28 35
BHLHE40 -0.094 0.09 -10000 0 -0.2 169 169
BHLHE41 -0.094 0.09 -10000 0 -0.2 169 169
HIF1A/ARNT/SMAD3/SMAD4/SP1 0.01 0.093 0.23 6 -0.1 93 99
ENG -0.035 0.079 0.27 9 -10000 0 9
JUN 0.032 0.005 -10000 0 -10000 0 0
RORA -0.055 0.17 0.5 11 -0.28 18 29
ABCB1 -0.011 0.045 -10000 0 -0.34 5 5
TFRC -0.057 0.16 0.49 13 -0.28 18 31
CXCR4 -0.073 0.16 0.47 10 -0.28 42 52
TF -0.082 0.11 0.4 1 -0.28 18 19
CITED2 -0.059 0.16 0.49 10 -0.29 18 28
HIF1A/ARNT -0.07 0.14 0.27 11 -0.24 129 140
LDHA 0.003 0.057 -10000 0 -0.46 6 6
ETS1 -0.053 0.17 0.49 13 -0.28 18 31
PGK1 -0.054 0.17 0.53 9 -0.28 18 27
NOS2 -0.094 0.09 -10000 0 -0.2 169 169
ITGB2 -0.061 0.17 0.5 12 -0.28 39 51
ALDOA -0.055 0.17 0.48 10 -0.28 17 27
Cbp/p300/CITED2 -0.095 0.1 -10000 0 -0.24 106 106
FOS 0.008 0.04 -10000 0 -0.063 120 120
HK2 -0.054 0.17 0.48 14 -0.28 18 32
SP1 0.034 0.007 -10000 0 -0.041 2 2
GCK 0.004 0.088 0.36 7 -0.37 3 10
HK1 -0.076 0.13 0.48 4 -0.28 19 23
NPM1 -0.058 0.16 0.55 6 -0.28 18 24
EGLN1 -0.058 0.16 0.5 9 -0.28 17 26
CREB1 0.035 0.008 -10000 0 -0.085 2 2
PGM1 -0.054 0.17 0.48 14 -0.28 17 31
SMAD3 0.032 0.005 -10000 0 -10000 0 0
EDN1 -0.017 0.082 -10000 0 -0.36 9 9
IGFBP1 -0.045 0.15 0.47 12 -0.29 15 27
VEGFA -0.076 0.13 0.36 12 -0.28 34 46
HIF1A/JAB1 0.009 0.052 0.14 5 -0.053 157 162
CP -0.064 0.16 0.48 10 -0.3 23 33
CXCL12 -0.066 0.15 0.46 10 -0.28 22 32
COPS5 0.033 0.004 -10000 0 -10000 0 0
SMAD3/SMAD4 0.024 0.041 -10000 0 -0.05 113 113
BNIP3 -0.073 0.13 0.47 1 -0.29 17 18
EGLN3 -0.057 0.16 0.51 9 -0.29 17 26
CA9 -0.058 0.16 0.51 10 -0.29 19 29
TERT -0.051 0.17 0.5 12 -0.28 17 29
ENO1 -0.057 0.16 0.47 14 -0.28 17 31
PFKL -0.052 0.17 0.5 11 -0.29 15 26
NCOA1 0.031 0.007 -10000 0 -10000 0 0
ADM -0.072 0.16 0.5 8 -0.29 26 34
ARNT -0.014 0.055 0.15 7 -0.084 17 24
HNF4A 0.031 0.009 -10000 0 -10000 0 0
ADFP -0.094 0.09 -10000 0 -0.2 169 169
SLC2A1 -0.063 0.13 0.37 13 -0.29 20 33
LEP -0.045 0.14 0.47 10 -0.28 13 23
HIF1A/ARNT/Cbp/p300 -0.077 0.1 -10000 0 -0.24 74 74
EPO -0.032 0.11 0.32 13 -0.34 23 36
CREBBP 0.002 0.055 0.24 9 -0.19 2 11
HIF1A/ARNT/Cbp/p300/HDAC7 -0.082 0.1 -10000 0 -0.23 99 99
PFKFB3 -0.065 0.15 0.47 8 -0.28 19 27
NT5E -0.062 0.16 0.5 8 -0.29 19 27
Aurora B signaling

Figure S16.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S16.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Condensin I complex -0.029 0.047 -10000 0 -0.12 80 80
STMN1 -0.023 0.008 -10000 0 -0.05 24 24
Aurora B/RasGAP/Survivin 0.017 0.057 -10000 0 -0.053 196 196
Chromosomal passenger complex/Cul3 protein complex -0.034 0.056 -10000 0 -0.1 175 175
BIRC5 -0.007 0.048 -10000 0 -0.066 201 201
DES 0.016 0.11 -10000 0 -0.68 11 11
Aurora C/Aurora B/INCENP 0.049 0.033 -10000 0 -0.044 39 39
Aurora B/TACC1 0.038 0.019 -10000 0 -0.04 23 23
Aurora B/PP2A 0.042 0.023 -10000 0 -0.05 26 26
mol:GTP 0 0 -10000 0 -10000 0 0
CBX5 0.006 0.005 -10000 0 -0.014 24 24
mitotic metaphase/anaphase transition -0.001 0.002 0.018 2 -10000 0 2
NDC80 -0.032 0.017 -10000 0 -0.054 164 164
Cul3 protein complex 0.028 0.021 -10000 0 -10000 0 0
KIF2C -0.005 0.042 -10000 0 -0.14 23 23
PEBP1 0.031 0.005 -10000 0 -10000 0 0
KIF20A -0.002 0.046 -10000 0 -0.064 178 178
mol:GDP 0 0 -10000 0 -10000 0 0
Aurora B/RasGAP 0.041 0.023 -10000 0 -0.051 23 23
SEPT1 0 0 -10000 0 -10000 0 0
SMC2 0.021 0.03 -10000 0 -0.063 56 56
SMC4 -0.039 0.041 -10000 0 -0.063 378 378
NSUN2/NPM1/Nucleolin -0.009 0.086 -10000 0 -0.55 11 11
PSMA3 0.031 0.008 -10000 0 0 32 32
G2/M transition of mitotic cell cycle -0.001 0.002 0.015 1 -10000 0 1
H3F3B 0.01 0.011 -10000 0 -0.037 25 25
AURKB 0.026 0.023 -10000 0 -0.062 29 29
AURKC 0.03 0.01 -10000 0 -0.063 2 2
CDCA8 0.028 0.018 -10000 0 -0.065 16 16
cytokinesis -0.02 0.064 0.15 1 -0.2 33 34
Aurora B/Septin1 -0.012 0.068 0.14 1 -0.21 28 29
AURKA 0.027 0.018 -10000 0 -0.062 16 16
INCENP 0.032 0.005 0.065 1 -0.026 1 2
KLHL13 0 0 -10000 0 -10000 0 0
BUB1 0.032 0.009 -10000 0 -0.062 4 4
hSgo1/Aurora B/Survivin 0.008 0.039 -10000 0 -0.039 203 203
EVI5 0.031 0.006 -10000 0 -10000 0 0
RhoA/GTP 0.008 0.072 0.16 1 -0.15 34 35
SGOL1 0 0 -10000 0 -10000 0 0
CENPA 0 0.044 -10000 0 -0.16 23 23
NCAPG 0.011 0.039 -10000 0 -0.063 111 111
Aurora B/HC8 Proteasome 0.04 0.023 -10000 0 -0.05 21 21
NCAPD2 0.014 0.037 -10000 0 -0.063 93 93
Aurora B/PP1-gamma 0.041 0.023 -10000 0 -0.05 25 25
RHOA 0.032 0.006 -10000 0 -10000 0 0
NCAPH 0.03 0.016 -10000 0 -0.063 15 15
NPM1 -0.003 0.084 -10000 0 -0.39 17 17
RASA1 0.032 0.006 -10000 0 -10000 0 0
KLHL9 0.021 0.016 -10000 0 -10000 0 0
mitotic prometaphase -0.001 0.002 0.015 1 -10000 0 1
proteasomal ubiquitin-dependent protein catabolic process 0.04 0.023 -10000 0 -0.05 21 21
PPP1CC 0.032 0.004 -10000 0 -10000 0 0
Centraspindlin 0.002 0.068 0.16 1 -0.15 38 39
RhoA/GDP 0.023 0.004 -10000 0 0 15 15
NSUN2 -0.004 0.048 -10000 0 -0.31 11 11
MYLK 0.009 0.013 -10000 0 -0.038 34 34
KIF23 0.017 0.035 -10000 0 -0.066 77 77
VIM -0.019 0.013 0.021 1 -0.05 33 34
RACGAP1 0.002 0.045 -10000 0 -0.065 154 154
mitosis 0 0 -10000 0 -10000 0 0
NCL 0.004 0.048 -10000 0 -0.29 12 12
Chromosomal passenger complex -0.009 0.043 0.086 1 -0.13 36 37
Chromosomal passenger complex/EVI5 0.028 0.075 -10000 0 -0.093 16 16
TACC1 0.032 0.004 -10000 0 -10000 0 0
PPP2R5D 0.032 0.004 -10000 0 -10000 0 0
CUL3 0.033 0.001 -10000 0 -10000 0 0
response to DNA damage stimulus 0 0 -10000 0 -10000 0 0
Osteopontin-mediated events

Figure S17.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S17.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IKK alpha homodimer -0.035 0.035 0.17 5 -10000 0 5
NF kappa B1 p50/RelA/I kappa B alpha -0.058 0.053 0.22 4 -0.19 18 22
alphaV/beta3 Integrin/Osteopontin/Src 0.01 0.05 -10000 0 -0.057 179 179
AP1 -0.061 0.065 -10000 0 -0.14 66 66
ILK -0.04 0.026 0.16 5 -10000 0 5
bone resorption -0.063 0.029 0.15 4 -10000 0 4
PTK2B 0.032 0.005 -10000 0 -10000 0 0
PYK2/p130Cas 0.01 0.062 0.16 4 -0.085 17 21
ITGAV 0.029 0.017 -10000 0 -0.066 15 15
mol:GTP 0 0 -10000 0 -10000 0 0
CD44/Rho Family GTPase/ROCK2 -0.029 0.039 -10000 0 -0.05 394 394
alphaV/beta3 Integrin/Osteopontin 0.02 0.061 -10000 0 -0.07 76 76
MAP3K1 -0.041 0.028 0.17 6 -10000 0 6
JUN 0.031 0.005 -10000 0 -10000 0 0
MAPK3 -0.047 0.032 0.16 5 -10000 0 5
MAPK1 -0.044 0.036 0.17 6 -10000 0 6
Rac1/GDP 0.017 0.011 -10000 0 -10000 0 0
NFKB1 0.031 0.009 -10000 0 -0.063 4 4
MAPK8 -0.036 0.032 0.16 4 -10000 0 4
ITGB3 0.031 0.004 -10000 0 -10000 0 0
NFKBIA -0.047 0.043 0.16 5 -0.17 19 24
FOS 0.007 0.04 -10000 0 -0.064 120 120
CD44 -0.043 0.038 -10000 0 -0.063 397 397
CHUK 0.024 0.015 -10000 0 -0.063 1 1
PLAU -0.07 0.065 -10000 0 -0.3 4 4
NF kappa B1 p50/RelA -0.066 0.047 0.18 3 -10000 0 3
BCAR1 0 0 -10000 0 -10000 0 0
RELA 0.032 0.004 -10000 0 -10000 0 0
alphaV beta3 Integrin 0.044 0.019 -10000 0 -0.055 15 15
mol:GDP 0 0 -10000 0 -10000 0 0
SYK -0.041 0.027 0.17 5 -10000 0 5
VAV3 -0.044 0.029 0.16 5 -10000 0 5
MAP3K14 -0.042 0.03 0.17 6 -10000 0 6
ROCK2 0.032 0.003 -10000 0 -10000 0 0
SPP1 -0.003 0.047 -10000 0 -0.066 175 175
RAC1 0.023 0.015 -10000 0 -10000 0 0
Rac1/GTP -0.035 0.032 0.16 3 -10000 0 3
MMP2 -0.083 0.044 0.26 1 -0.16 1 2
Wnt signaling

Figure S18.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S18.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Noncanonical Wnts/FZD 0 0.039 -9999 0 -0.12 23 23
FZD6 0.014 0.037 -9999 0 -0.063 94 94
WNT6 0.032 0.002 -9999 0 -10000 0 0
WNT4 0.031 0.008 -9999 0 -0.063 2 2
FZD3 0.031 0.01 -9999 0 -0.063 3 3
WNT5A 0.003 0.044 -9999 0 -0.063 155 155
WNT11 0.032 0.007 -9999 0 -0.063 2 2
Syndecan-4-mediated signaling events

Figure S19.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S19.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 0 0.059 -10000 0 -0.32 10 10
Syndecan-4/Syndesmos -0.031 0.11 -10000 0 -0.42 22 22
positive regulation of JNK cascade -0.036 0.11 -10000 0 -0.35 29 29
Syndecan-4/ADAM12 -0.022 0.12 -10000 0 -0.41 24 24
CCL5 0.028 0.021 -10000 0 -0.063 25 25
Rac1/GDP 0.017 0.011 -10000 0 -10000 0 0
DNM2 0.031 0.006 -10000 0 -10000 0 0
ITGA5 0.019 0.033 -10000 0 -0.063 68 68
SDCBP 0.032 0.004 -10000 0 -10000 0 0
PLG 0.024 0.022 -10000 0 -0.047 18 18
ADAM12 0.023 0.015 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
NUDT16L1 0 0 -10000 0 -10000 0 0
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
Syndecan-4/PKC alpha -0.037 0.02 -10000 0 -10000 0 0
Syndecan-4/Laminin alpha1 -0.031 0.11 -10000 0 -0.42 22 22
Syndecan-4/CXCL12/CXCR4 -0.038 0.11 -10000 0 -0.4 25 25
Syndecan-4/Laminin alpha3 -0.016 0.12 -10000 0 -0.42 22 22
MDK -0.022 0.046 -10000 0 -0.063 283 283
Syndecan-4/FZD7 -0.034 0.12 -10000 0 -0.43 22 22
Syndecan-4/Midkine -0.037 0.11 -10000 0 -0.42 23 23
FZD7 -0.012 0.048 -10000 0 -0.063 238 238
Syndecan-4/FGFR1/FGF -0.005 0.12 -10000 0 -0.37 27 27
THBS1 0.024 0.026 -10000 0 -0.063 39 39
integrin-mediated signaling pathway -0.048 0.1 -10000 0 -0.38 27 27
positive regulation of MAPKKK cascade -0.036 0.11 -10000 0 -0.35 29 29
Syndecan-4/TACI -0.015 0.12 -10000 0 -0.42 23 23
CXCR4 -0.017 0.048 -10000 0 -0.063 263 263
cell adhesion -0.007 0.03 0.2 3 -0.085 14 17
Syndecan-4/Dynamin -0.018 0.12 -10000 0 -0.42 22 22
Syndecan-4/TSP1 -0.018 0.12 -10000 0 -0.43 22 22
Syndecan-4/GIPC -0.018 0.12 -10000 0 -0.42 22 22
Syndecan-4/RANTES -0.016 0.12 -10000 0 -0.43 22 22
ITGB1 0.025 0.014 -10000 0 -10000 0 0
LAMA1 0 0 -10000 0 -10000 0 0
LAMA3 0.029 0.017 -10000 0 -0.063 15 15
RAC1 0.023 0.015 -10000 0 -10000 0 0
PRKCA -0.003 0.081 0.8 5 -10000 0 5
Syndecan-4/alpha-Actinin -0.018 0.12 -10000 0 -0.42 23 23
TFPI 0.012 0.039 -10000 0 -0.063 111 111
F2 0.029 0.02 -10000 0 -0.045 14 14
alpha5/beta1 Integrin 0.025 0.034 -10000 0 -0.05 61 61
positive regulation of cell adhesion -0.026 0.11 -10000 0 -0.41 22 22
ACTN1 0.023 0.026 -10000 0 -0.063 40 40
TNC -0.056 0.022 -10000 0 -0.063 469 469
Syndecan-4/CXCL12 -0.022 0.12 -10000 0 -0.41 24 24
FGF6 0.031 0.007 -10000 0 -10000 0 0
RHOA 0.032 0.006 -10000 0 -10000 0 0
CXCL12 0.023 0.019 -10000 0 -0.063 12 12
TNFRSF13B 0.032 0.004 -10000 0 -10000 0 0
FGF2 0.032 0.007 -10000 0 -0.063 2 2
FGFR1 0.032 0.005 -10000 0 -0.063 1 1
Syndecan-4/PI-4-5-P2 -0.031 0.11 -10000 0 -0.42 22 22
mol:GDP 0 0 -10000 0 -10000 0 0
FN1 0.01 0.039 -10000 0 -0.056 111 111
cell migration -0.019 0.012 -10000 0 -10000 0 0
PRKCD 0.026 0.022 -10000 0 -0.053 10 10
vasculogenesis -0.017 0.12 -10000 0 -0.41 22 22
SDC4 -0.029 0.11 -10000 0 -0.41 26 26
Syndecan-4/Tenascin C -0.049 0.11 -10000 0 -0.39 27 27
Syndecan-4/PI-4-5-P2/PKC alpha -0.03 0.016 -10000 0 -10000 0 0
Syndecan-4/Syntenin -0.015 0.12 -10000 0 -0.42 22 22
MMP9 -0.004 0.044 -10000 0 -0.06 177 177
Rac1/GTP -0.007 0.031 0.2 3 -0.087 14 17
cytoskeleton organization -0.03 0.1 -10000 0 -0.4 22 22
GIPC1 0.031 0.006 -10000 0 -10000 0 0
Syndecan-4/TFPI -0.023 0.12 -10000 0 -0.42 22 22
Syndecan-1-mediated signaling events

Figure S20.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S20.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 0.026 0.022 -10000 0 -0.063 26 26
CCL5 0.028 0.021 -10000 0 -0.051 31 31
SDCBP 0.032 0.004 -10000 0 -10000 0 0
FGFR/FGF2/Syndecan-1 -0.011 0.046 0.1 17 -0.14 21 38
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
RP11-540L11.1 0 0 -10000 0 -10000 0 0
Syndecan-1/Laminin-5 -0.009 0.053 0.17 2 -0.18 16 18
Syndecan-1/Syntenin 0.003 0.066 0.2 16 -0.21 10 26
MAPK3 -0.034 0.052 0.16 4 -0.16 28 32
HGF/MET 0.031 0.024 -10000 0 -0.05 3 3
TGFB1/TGF beta receptor Type II 0.026 0.022 -10000 0 -0.063 26 26
BSG 0.031 0.007 -10000 0 -10000 0 0
keratinocyte migration -0.009 0.052 0.17 2 -0.18 16 18
Syndecan-1/RANTES 0.001 0.069 0.2 16 -0.2 14 30
Syndecan-1/CD147 -0.026 0.058 0.19 4 -0.18 20 24
Syndecan-1/Syntenin/PIP2 0.002 0.063 0.19 16 -0.2 10 26
LAMA5 0.027 0.017 -10000 0 -0.063 13 13
positive regulation of cell-cell adhesion 0.002 0.062 0.19 16 -0.2 10 26
MMP7 0.018 0.034 -10000 0 -0.063 75 75
HGF 0.022 0.016 -10000 0 -0.063 1 1
Syndecan-1/CASK -0.013 0.045 0.09 17 -0.19 14 31
Syndecan-1/HGF/MET 0.004 0.058 0.22 4 -0.21 10 14
regulation of cell adhesion -0.034 0.07 0.22 19 -0.2 14 33
HPSE 0.024 0.027 -10000 0 -0.063 44 44
positive regulation of cell migration -0.011 0.046 0.1 17 -0.14 21 38
SDC1 -0.009 0.042 0.1 17 -0.11 28 45
Syndecan-1/Collagen -0.011 0.046 0.1 17 -0.14 21 38
PPIB -0.035 0.043 -10000 0 -0.063 355 355
MET 0.022 0.016 -10000 0 -0.063 2 2
PRKACA 0.032 0.006 -10000 0 0 17 17
MMP9 -0.001 0.044 -10000 0 -0.063 165 165
MAPK1 -0.033 0.051 0.16 4 -0.16 27 31
homophilic cell adhesion -0.009 0.052 0.18 6 -0.19 13 19
MMP1 0.025 0.025 -10000 0 -0.063 38 38
Signaling events mediated by Stem cell factor receptor (c-Kit)

Figure S21.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S21.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAP4K1 -0.022 0.096 0.19 15 -0.3 47 62
CRKL -0.022 0.095 0.18 1 -0.31 48 49
HRAS -0.006 0.095 0.17 1 -0.27 46 47
mol:PIP3 0.038 0.12 0.25 29 -0.28 37 66
SPRED1 0 0 -10000 0 -10000 0 0
SPRED2 0.032 0.003 -10000 0 -10000 0 0
GAB1 -0.014 0.098 -10000 0 -0.31 47 47
FOXO3 0.025 0.13 0.25 25 -0.3 41 66
AKT1 0.03 0.14 0.24 27 -0.32 41 68
BAD 0.024 0.13 0.23 25 -0.3 41 66
megakaryocyte differentiation -0.012 0.089 -10000 0 -0.3 43 43
GSK3B 0.025 0.13 0.25 24 -0.3 41 65
RAF1 -0.012 0.081 0.16 6 -0.23 47 53
SHC1 0.024 0.026 -10000 0 -0.063 40 40
STAT3 -0.016 0.098 -10000 0 -0.31 47 47
STAT1 -0.033 0.17 -10000 0 -0.56 46 46
HRAS/SPRED1 -0.008 0.081 0.15 1 -0.23 46 47
cell proliferation -0.019 0.095 -10000 0 -0.31 47 47
PIK3CA 0.028 0.018 -10000 0 -0.062 17 17
TEC 0.032 0.005 -10000 0 -10000 0 0
RPS6KB1 0.015 0.11 0.21 1 -0.32 33 34
HRAS/SPRED2 0.006 0.091 0.19 3 -0.23 46 49
LYN/TEC/p62DOK 0.024 0.12 -10000 0 -0.31 47 47
MAPK3 -0.007 0.07 0.18 16 -0.17 35 51
STAP1 -0.015 0.098 -10000 0 -0.31 47 47
GRAP2 0.03 0.008 -10000 0 -10000 0 0
JAK2 -0.029 0.16 -10000 0 -0.5 47 47
STAT1 (dimer) -0.031 0.17 -10000 0 -0.55 47 47
mol:Gleevec 0 0.005 -10000 0 -10000 0 0
GRB2/SOCS1/VAV1 0.032 0.12 -10000 0 -0.31 46 46
actin filament polymerization -0.01 0.096 -10000 0 -0.3 47 47
LYN 0.021 0.031 -10000 0 -0.063 60 60
STAP1/STAT5A (dimer) -0.024 0.13 0.21 1 -0.4 47 48
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
CBL/CRKL/GRB2 0.007 0.1 0.2 3 -0.3 48 51
PI3K 0.038 0.12 0.24 1 -0.31 31 32
PTEN 0.023 0.016 -10000 0 -0.063 2 2
SCF/KIT/EPO/EPOR -0.016 0.18 -10000 0 -0.57 46 46
MAPK8 -0.019 0.096 -10000 0 -0.31 47 47
STAT3 (dimer) -0.016 0.097 -10000 0 -0.31 47 47
positive regulation of transcription -0.004 0.061 0.17 16 -0.16 17 33
mol:GDP 0.001 0.099 -10000 0 -0.28 46 46
PIK3C2B -0.017 0.097 -10000 0 -0.31 46 46
CBL/CRKL -0.005 0.1 0.2 4 -0.3 48 52
FER -0.015 0.098 -10000 0 -0.31 46 46
SH2B3 -0.015 0.097 -10000 0 -0.31 47 47
PDPK1 0.032 0.11 0.23 30 -0.26 36 66
SNAI2 -0.021 0.098 -10000 0 -0.32 47 47
positive regulation of cell proliferation -0.029 0.15 -10000 0 -0.47 49 49
KITLG 0.027 0.023 -10000 0 -0.044 45 45
cell motility -0.029 0.15 -10000 0 -0.47 49 49
PTPN6 0.029 0.017 -10000 0 -0.049 18 18
EPOR 0.016 0.077 -10000 0 -0.49 3 3
STAT5A (dimer) -0.018 0.13 -10000 0 -0.4 47 47
SOCS1 0.032 0.004 -10000 0 -10000 0 0
cell migration 0.015 0.095 0.31 45 -10000 0 45
SOS1 0 0 -10000 0 -10000 0 0
EPO 0.02 0.02 -10000 0 -0.033 27 27
VAV1 0.032 0.007 -10000 0 -0.063 1 1
GRB10 -0.011 0.076 -10000 0 -0.32 28 28
PTPN11 0.031 0.01 -10000 0 -0.028 11 11
SCF/KIT -0.008 0.1 -10000 0 -0.32 47 47
GO:0007205 0.001 0.005 -10000 0 -10000 0 0
MAP2K1 -0.017 0.068 0.15 9 -0.19 46 55
CBL 0.032 0.004 -10000 0 -10000 0 0
KIT -0.037 0.2 -10000 0 -0.64 50 50
MAP2K2 -0.015 0.075 0.2 16 -0.19 46 62
SHC/Grb2/SOS1 0.012 0.11 -10000 0 -0.31 47 47
STAT5A -0.017 0.13 -10000 0 -0.41 46 46
GRB2 0.032 0.006 -10000 0 -10000 0 0
response to radiation -0.02 0.096 -10000 0 -0.31 47 47
SHC/GRAP2 0.037 0.028 -10000 0 -0.05 38 38
PTPRO -0.012 0.091 -10000 0 -0.3 43 43
SH2B2 -0.01 0.098 -10000 0 -0.31 47 47
DOK1 0.032 0.002 -10000 0 -10000 0 0
MATK -0.015 0.096 -10000 0 -0.31 45 45
CREBBP 0.026 0.043 -10000 0 -0.1 47 47
BCL2 0.007 0.12 -10000 0 -0.64 9 9
Ras signaling in the CD4+ TCR pathway

Figure S22.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S22.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ERK1-2/ELK1 0.02 0.071 0.3 1 -0.24 14 15
MAP3K8 0.018 0.026 -10000 0 -0.063 37 37
FOS 0.011 0.062 0.25 2 -0.24 13 15
PRKCA 0.031 0.004 -10000 0 -10000 0 0
PTPN7 0.03 0.008 0.066 1 -0.044 2 3
HRAS 0.031 0.007 -10000 0 -10000 0 0
PRKCB -0.001 0.002 0.018 1 -0.003 119 120
NRAS 0.008 0.041 -10000 0 -0.063 125 125
RAS family/GTP 0.03 0.046 -10000 0 -0.044 121 121
MAPK3 0.026 0.032 -10000 0 -0.36 2 2
MAP2K1 -0.003 0.026 0.12 1 -0.18 2 3
ELK1 0.031 0.005 -10000 0 -0.022 2 2
BRAF 0.004 0.017 -10000 0 -0.23 2 2
mol:GTP 0 0 0.003 1 -0.001 124 125
MAPK1 0 0.1 -10000 0 -0.35 36 36
RAF1 0.006 0.016 0.098 1 -0.22 2 3
KRAS 0.03 0.008 -10000 0 -10000 0 0
PLK1 signaling events

Figure S23.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S23.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
regulation of centriole-centriole cohesion -0.001 0.009 -10000 0 -0.029 30 30
BUB1B -0.012 0.035 0.084 12 -0.12 22 34
PLK1 0.007 0.023 0.071 35 -0.092 4 39
PLK1S1 0.003 0.014 0.042 35 -0.047 4 39
KIF2A -0.001 0.025 0.16 5 -0.097 3 8
regulation of mitotic centrosome separation 0.007 0.023 0.071 35 -0.092 4 39
GOLGA2 0.031 0.006 -10000 0 -10000 0 0
Hec1/SPC24 0.008 0.028 0.11 2 -0.079 9 11
WEE1 -0.018 0.066 -10000 0 -0.34 15 15
cytokinesis -0.011 0.04 0.16 3 -0.15 12 15
PP2A-alpha B56 0.056 0.077 -10000 0 -0.56 7 7
AURKA 0.007 0.017 0.092 4 -0.14 2 6
PICH/PLK1 -0.031 0.021 0.098 2 -0.087 12 14
CENPE -0.003 0.026 0.14 7 -0.12 3 10
RhoA/GTP 0.023 0.004 -10000 0 0 15 15
positive regulation of microtubule depolymerization -0.001 0.026 0.18 4 -0.1 2 6
PPP2CA 0.032 0.005 -10000 0 -10000 0 0
FZR1 0.031 0.006 -10000 0 -10000 0 0
TPX2 -0.01 0.025 0.13 1 -0.09 1 2
PAK1 0.032 0.005 -10000 0 -10000 0 0
SPC24 0 0 -10000 0 -10000 0 0
FBXW11 0.032 0.005 -10000 0 -10000 0 0
CLSPN 0.009 0.031 0.1 2 -0.23 7 9
GORASP1 0.032 0.005 -10000 0 -10000 0 0
metaphase 0 0.002 0.016 4 -0.011 3 7
mol:GTP 0 0 -10000 0 -10000 0 0
NLP 0.003 0.014 0.042 35 -0.047 4 39
G2 phase of mitotic cell cycle -0.001 0.002 0.01 8 -0.011 1 9
STAG2 0.028 0.021 -10000 0 -0.063 26 26
GRASP65/GM130/RAB1/GTP 0.011 0.067 -10000 0 -0.51 8 8
spindle elongation 0.007 0.023 0.071 35 -0.092 4 39
ODF2 0.032 0.007 -10000 0 -10000 0 0
BUB1 0.023 0.074 -10000 0 -0.59 7 7
TPT1 -0.005 0.055 0.087 1 -0.19 39 40
CDC25C 0.011 0.031 -10000 0 -0.25 6 6
CDC25B 0.026 0.018 -10000 0 -0.059 17 17
SGOL1 0.001 0.009 0.029 30 -10000 0 30
RHOA 0.032 0.006 -10000 0 -10000 0 0
CCNB1/CDK1 -0.011 0.047 -10000 0 -0.092 34 34
CDC14B -0.011 0.004 0.009 11 -10000 0 11
CDC20 -0.022 0.047 -10000 0 -0.063 287 287
PLK1/PBIP1 -0.017 0.015 0.054 3 -0.069 12 15
mitosis -0.003 0.003 0.015 5 -10000 0 5
FBXO5 -0.013 0.033 0.11 7 -0.095 35 42
CDC2 -0.001 0.002 -10000 0 -0.01 3 3
NDC80 0 0.045 -10000 0 -0.063 170 170
metaphase plate congression 0.009 0.033 0.099 1 -0.23 8 9
ERCC6L -0.024 0.036 -10000 0 -0.098 31 31
NLP/gamma Tubulin 0.004 0.016 0.069 9 -0.064 6 15
microtubule cytoskeleton organization -0.005 0.055 0.087 1 -0.19 39 40
G2/M transition DNA damage checkpoint 0 0.002 0.011 5 -10000 0 5
PPP1R12A 0.032 0.006 -10000 0 -10000 0 0
interphase 0 0.002 0.011 5 -10000 0 5
PLK1/PRC1-2 0.007 0.047 0.13 3 -0.078 24 27
GRASP65/GM130/RAB1/GTP/PLK1 0.053 0.029 0.14 1 -0.086 5 6
RAB1A 0.032 0.004 -10000 0 -10000 0 0
prophase 0 0 -10000 0 -10000 0 0
Aurora A/BORA 0.006 0.022 0.067 43 -0.06 4 47
mitotic prometaphase -0.001 0.003 0.019 8 -10000 0 8
proteasomal ubiquitin-dependent protein catabolic process -0.039 0.097 0.13 3 -0.23 100 103
microtubule-based process 0.009 0.031 0.12 3 -0.081 10 13
Golgi organization 0.007 0.023 0.071 35 -0.092 4 39
Cohesin/SA2 0.021 0.022 0.096 3 -0.07 6 9
PPP1CB/MYPT1 0.047 0.01 -10000 0 -0.046 1 1
KIF20A -0.001 0.045 -10000 0 -0.063 178 178
APC/C/CDC20 -0.001 0.03 0.12 1 -0.076 13 14
PPP2R1A 0.03 0.009 -10000 0 -10000 0 0
chromosome segregation -0.017 0.015 0.054 3 -0.068 12 15
PRC1 -0.008 0.047 -10000 0 -0.063 213 213
ECT2 -0.005 0.036 0.18 11 -0.12 3 14
C13orf34 0.005 0.02 0.064 35 -0.068 4 39
NUDC 0.009 0.033 0.1 1 -0.23 8 9
regulation of attachment of spindle microtubules to kinetochore -0.012 0.034 0.084 12 -0.12 22 34
spindle assembly 0.004 0.02 0.063 28 -0.077 4 32
spindle stabilization 0.003 0.014 0.042 35 -0.047 4 39
APC/C/HCDH1 0.025 0.007 -10000 0 -10000 0 0
MKLP2/PLK1 0.009 0.031 0.12 3 -0.081 10 13
CCNB1 -0.02 0.048 -10000 0 -0.063 280 280
PPP1CB 0.032 0.007 -10000 0 -0.058 2 2
BTRC 0.024 0.014 -10000 0 -10000 0 0
ROCK2 0.016 0.025 0.14 1 -0.22 2 3
TUBG1 0.009 0.022 0.086 2 -0.18 4 6
G2/M transition of mitotic cell cycle -0.025 0.029 -10000 0 -0.092 32 32
MLF1IP -0.034 0.012 -10000 0 -0.04 420 420
INCENP 0.032 0.004 -10000 0 -10000 0 0
Signaling events mediated by VEGFR1 and VEGFR2

Figure S24.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S24.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
alphaV beta3 Integrin 0.045 0.018 -10000 0 -0.05 15 15
AKT1 -0.023 0.074 0.21 7 -0.27 16 23
PTK2B -0.034 0.059 0.16 39 -10000 0 39
VEGFR2 homodimer/Frs2 0.025 0.024 -10000 0 -0.089 13 13
CAV1 -0.018 0.041 -10000 0 -0.063 218 218
CALM1 0.029 0.01 -10000 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/Frs2 -0.004 0.05 -10000 0 -0.081 29 29
endothelial cell proliferation -0.005 0.079 0.21 25 -0.25 10 35
mol:Ca2+ -0.03 0.052 0.15 33 -0.12 2 35
VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Rac -0.002 0.059 0.17 12 -0.1 14 26
RP11-342D11.1 -0.032 0.037 0.16 15 -0.098 11 26
CDH5 0.027 0.022 -10000 0 -0.063 29 29
VEGFA homodimer 0.002 0.052 -10000 0 -0.043 274 274
SHC1 0.024 0.026 -10000 0 -0.063 40 40
SHC2 0.031 0.007 -10000 0 -10000 0 0
HRAS/GDP -0.017 0.053 -10000 0 -0.096 29 29
SH2D2A 0.032 0.005 -10000 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/SHP1/eNOS 0.007 0.06 0.2 2 -0.2 3 5
VEGFR2 homodimer/VEGFA homodimer/TsAd -0.005 0.051 -10000 0 -0.082 30 30
VEGFR1 homodimer 0.03 0.008 -10000 0 -10000 0 0
SHC/GRB2/SOS1 -0.003 0.068 0.16 13 -0.11 15 28
GRB10 -0.021 0.047 0.16 24 -0.12 1 25
PTPN11 0.032 0.003 -10000 0 -10000 0 0
GRB2 0.032 0.006 -10000 0 -10000 0 0
PAK1 0.032 0.004 -10000 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Cadherin/beta catenin -0.005 0.076 0.18 12 -0.11 21 33
HRAS 0.031 0.007 -10000 0 -10000 0 0
VEGF/Rho/ROCK1/Integrin Complex -0.004 0.046 0.13 11 -0.21 8 19
HIF1A 0.03 0.01 -10000 0 -0.063 2 2
FRS2 0.031 0.007 -10000 0 -10000 0 0
oxygen and reactive oxygen species metabolic process -0.002 0.058 0.17 12 -0.1 14 26
mol:GTP 0 0 -10000 0 -10000 0 0
FLT4 0.032 0.004 -10000 0 -10000 0 0
Nck/Pak 0.044 0.017 -10000 0 -0.05 11 11
VEGFR2 homodimer/VEGFA homodimer/Fyn -0.007 0.05 -10000 0 -0.074 46 46
mol:GDP -0.011 0.056 -10000 0 -0.094 29 29
mol:NADP 0.005 0.058 0.25 4 -0.2 1 5
eNOS/Hsp90 0.014 0.06 0.26 4 -0.2 1 5
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
mol:IP3 -0.03 0.052 0.15 33 -0.12 2 35
HIF1A/ARNT 0.044 0.015 -10000 0 -0.05 2 2
SHB 0.03 0.009 -10000 0 -10000 0 0
VEGFA -0.019 0.048 -10000 0 -0.064 274 274
VEGFC 0.03 0.015 -10000 0 -0.063 11 11
FAK1/Vinculin -0.004 0.059 0.2 11 -0.2 9 20
mol:Ca ++ 0 0 -10000 0 -10000 0 0
RHOA 0.032 0.006 -10000 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin 0.003 0.067 0.17 13 -0.1 14 27
PTPN6 0.029 0.015 -10000 0 -0.063 11 11
EPAS1 0.034 0.019 -10000 0 -0.072 16 16
mol:L-citrulline 0.005 0.058 0.25 4 -0.2 1 5
ITGAV 0.03 0.016 -10000 0 -0.063 15 15
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
VEGFR2 homodimer/VEGFA homodimer/Frs2/GRB2 0.004 0.065 0.17 13 -0.1 12 25
VEGFR2 homodimer/VEGFA homodimer -0.005 0.055 -10000 0 -0.081 45 45
VEGFR2/3 heterodimer 0.026 0.024 -10000 0 -0.089 14 14
VEGFB 0.032 0.004 -10000 0 -10000 0 0
MAPK11 -0.03 0.06 0.16 29 -0.17 14 43
VEGFR2 homodimer -0.02 0.015 -10000 0 -0.099 14 14
FLT1 0.03 0.008 -10000 0 -10000 0 0
NEDD4 0.028 0.019 -10000 0 -0.044 29 29
MAPK3 -0.019 0.065 0.19 15 -10000 0 15
MAPK1 -0.021 0.062 0.19 13 -10000 0 13
VEGFA145/NRP2 -0.005 0.049 -10000 0 -0.05 275 275
VEGFR1/2 heterodimer 0.024 0.025 -10000 0 -0.089 14 14
KDR -0.02 0.015 -10000 0 -0.1 14 14
VEGFA165/NRP1/VEGFR2 homodimer -0.002 0.06 0.16 14 -0.089 28 42
SRC 0.031 0.008 -10000 0 -10000 0 0
platelet activating factor biosynthetic process -0.018 0.066 0.2 15 -10000 0 15
PI3K -0.019 0.064 0.17 8 -0.18 15 23
VEGFR2 homodimer/VEGFA homodimer/NCK1 -0.006 0.051 -10000 0 -0.08 33 33
FES -0.032 0.054 0.16 36 -0.12 2 38
GAB1 -0.018 0.067 0.16 10 -0.19 31 41
VEGFR2 homodimer/VEGFA homodimer/Src -0.003 0.05 -10000 0 -0.08 32 32
CTNNB1 0.032 0.005 -10000 0 -10000 0 0
SOS1 0 0 -10000 0 -10000 0 0
ARNT 0.032 0.005 -10000 0 -10000 0 0
eNOS/Caveolin-1 -0.008 0.047 0.27 3 -0.19 2 5
VEGFR2 homodimer/VEGFA homodimer/Yes -0.013 0.051 -10000 0 -0.076 65 65
PI3K/GAB1 -0.02 0.076 0.17 8 -0.25 17 25
VEGFR2 homodimer/VEGFA homodimer/Frs2/Nck/Pak 0.006 0.073 0.18 12 -0.11 9 21
PRKACA 0.032 0.006 -10000 0 -10000 0 0
VEGFR2/3 heterodimer/VEGFC homodimer 0.041 0.031 -10000 0 -0.071 24 24
HSP90AA1 0.03 0.008 -10000 0 -10000 0 0
CDC42 -0.032 0.052 0.16 33 -0.12 2 35
actin cytoskeleton reorganization -0.005 0.051 -10000 0 -0.082 30 30
PTK2 -0.011 0.059 0.18 14 -0.2 9 23
EDG1 -0.032 0.037 0.16 15 -0.098 11 26
mol:DAG -0.03 0.052 0.15 33 -0.12 2 35
CaM/Ca2+ -0.031 0.051 0.15 30 -0.13 1 31
MAP2K3 -0.036 0.05 0.14 33 -0.13 1 34
VEGFR2 homodimer/VEGFA homodimer/GRB10/NEDD4 0.043 0.095 0.18 133 -0.1 17 150
PLCG1 -0.03 0.052 0.16 33 -0.12 2 35
VEGFR2 homodimer/VEGFA homodimer/Src/Shb 0.003 0.065 0.17 11 -0.1 14 25
IQGAP1 0.01 0.04 -10000 0 -0.063 120 120
YES1 0.017 0.034 -10000 0 -0.063 75 75
VEGFR2 homodimer/VEGFA homodimer/SHP2 -0.005 0.051 -10000 0 -0.077 36 36
VEGFR2 homodimer/VEGFA homodimer/SHP1 -0.007 0.051 -10000 0 -0.08 34 34
cell migration -0.009 0.075 0.2 11 -0.2 24 35
mol:PI-3-4-5-P3 -0.018 0.062 0.16 8 -0.17 15 23
FYN 0.029 0.011 -10000 0 -0.063 1 1
VEGFB/NRP1 -0.03 0.051 0.15 35 -0.12 2 37
mol:NO 0.005 0.058 0.25 4 -0.2 1 5
PXN 0.032 0.003 -10000 0 -10000 0 0
HRAS/GTP -0.047 0.023 -10000 0 -0.096 29 29
VEGFR2 homodimer/VEGFA homodimer/GRB10 -0.008 0.04 -10000 0 -0.09 25 25
VHL 0 0 -10000 0 -10000 0 0
ITGB3 0.032 0.003 -10000 0 -10000 0 0
NOS3 0.004 0.061 0.26 4 -0.22 1 5
VEGFR2 homodimer/VEGFA homodimer/Sck -0.004 0.05 -10000 0 -0.081 30 30
RAC1 0.023 0.015 -10000 0 -10000 0 0
PRKCA -0.033 0.05 0.14 34 -0.13 1 35
PRKCB -0.028 0.048 0.14 33 -0.12 1 34
VCL 0.025 0.014 -10000 0 -10000 0 0
VEGFA165/NRP1 -0.031 0.041 0.17 17 -0.12 2 19
VEGFR1/2 heterodimer/VEGFA homodimer -0.006 0.051 -10000 0 -0.075 44 44
VEGFA165/NRP2 -0.005 0.049 -10000 0 -0.05 275 275
MAPKKK cascade -0.033 0.039 0.18 6 -10000 0 6
NRP2 0.032 0.004 -10000 0 -0.063 1 1
VEGFC homodimer 0.029 0.015 -10000 0 -0.063 11 11
NCK1 0.03 0.015 -10000 0 -0.063 11 11
ROCK1 0.032 0.005 -10000 0 -10000 0 0
FAK1/Paxillin -0.002 0.068 0.2 14 -0.2 9 23
MAP3K13 -0.033 0.052 0.16 32 -0.12 2 34
PDPK1 -0.034 0.053 0.15 8 -0.16 14 22
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Figure S25.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S25.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HIF3A 0.031 0.007 -10000 0 -10000 0 0
oxygen homeostasis 0 0 -10000 0 -10000 0 0
TCEB2 0.032 0.004 -10000 0 -10000 0 0
TCEB1 0.032 0.005 -10000 0 -10000 0 0
HIF1A/p53 -0.05 0.14 0.22 2 -0.27 128 130
HIF1A -0.048 0.13 -10000 0 -0.32 90 90
COPS5 0.032 0.004 -10000 0 -10000 0 0
VHL/Elongin B/Elongin C/RBX1/CUL2 0.048 0.05 -10000 0 -10000 0 0
FIH (dimer) 0.024 0.014 -10000 0 -10000 0 0
CDKN2A 0.003 0.026 -10000 0 -0.063 52 52
ARNT/IPAS 0.045 0.013 -10000 0 -10000 0 0
HIF1AN 0.024 0.014 -10000 0 -10000 0 0
GNB2L1 0.032 0.004 -10000 0 -10000 0 0
HIF1A/ARNT -0.045 0.14 0.16 1 -0.26 126 127
CUL2 0.025 0.014 -10000 0 -10000 0 0
OS9 0.028 0.012 -10000 0 -10000 0 0
RACK1/Elongin B/Elongin C 0.063 0.017 -10000 0 -0.053 1 1
response to hypoxia 0 0 -10000 0 -10000 0 0
HIF1A/Hsp90 -0.044 0.14 0.2 3 -0.27 128 131
PHD1-3/OS9 0.059 0.043 -10000 0 -10000 0 0
HIF1A/RACK1/Elongin B/Elongin C -0.023 0.15 0.18 1 -0.27 126 127
VHL 0 0 -10000 0 -10000 0 0
HSP90AA1 0.03 0.008 -10000 0 -10000 0 0
HIF1A/JAB1 -0.045 0.14 0.22 2 -0.27 127 129
EGLN3 0.03 0.011 -10000 0 -0.063 4 4
EGLN2 0.031 0.006 -10000 0 -10000 0 0
EGLN1 0.032 0.007 -10000 0 -0.063 1 1
TP53 0.019 0.032 -10000 0 -0.063 65 65
VHL/Elongin B/Elongin C/RBX1/CUL2/HIF1A 0.002 0.07 -10000 0 -0.57 3 3
ARNT 0.032 0.005 -10000 0 -10000 0 0
ARD1A 0 0 -10000 0 -10000 0 0
RBX1 0.03 0.009 -10000 0 -10000 0 0
HIF1A/p19ARF -0.059 0.13 0.2 3 -0.27 128 131
S1P1 pathway

Figure S26.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S26.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR2 homodimer/VEGFA homodimer -0.004 0.047 -10000 0 -0.049 258 258
PDGFRB 0.032 0.007 -10000 0 -0.064 2 2
SPHK1 0.011 0.018 -10000 0 -10000 0 0
mol:S1P 0.005 0.023 -10000 0 -10000 0 0
S1P1/S1P/Gi -0.041 0.068 -10000 0 -0.28 20 20
GNAO1 0.003 0.009 -10000 0 -10000 0 0
PDGFB-D/PDGFRB/PLCgamma1 -0.037 0.08 0.2 16 -0.25 16 32
PLCG1 -0.04 0.061 -10000 0 -0.25 20 20
mol:GTP 0 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB 0.032 0.007 -10000 0 -0.064 2 2
GNAI2 0.035 0.007 -10000 0 -10000 0 0
GNAI3 0.021 0.03 -10000 0 -0.062 58 58
GNAI1 0.019 0.016 -10000 0 -0.06 1 1
mol:GDP 0 0 -10000 0 -10000 0 0
EDG1 -0.025 0.014 0.01 3 -0.038 233 236
S1P1/S1P -0.003 0.033 0.2 2 -10000 0 2
negative regulation of cAMP metabolic process -0.04 0.067 -10000 0 -0.27 20 20
MAPK3 -0.05 0.069 -10000 0 -0.28 20 20
calcium-dependent phospholipase C activity -0.001 0.001 -10000 0 -10000 0 0
Rac1/GDP 0.017 0.011 -10000 0 -10000 0 0
RhoA/GDP 0.023 0.004 -10000 0 0 15 15
KDR 0.028 0.018 -10000 0 -0.062 14 14
PLCB2 0.001 0.052 0.16 30 -10000 0 30
RAC1 0.023 0.015 -10000 0 -10000 0 0
RhoA/GTP -0.002 0.032 -10000 0 -10000 0 0
receptor internalization -0.003 0.032 0.19 2 -10000 0 2
PTGS2 -0.055 0.072 -10000 0 -0.33 12 12
Rac1/GTP -0.007 0.025 -10000 0 -10000 0 0
RHOA 0.032 0.006 -10000 0 -10000 0 0
VEGFA -0.018 0.047 -10000 0 -0.061 274 274
negative regulation of T cell proliferation -0.04 0.067 -10000 0 -0.27 20 20
GO:0007205 0 0 -10000 0 -10000 0 0
GNAZ 0.027 0.013 -10000 0 -10000 0 0
MAPK1 -0.047 0.068 -10000 0 -0.31 15 15
S1P1/S1P/PDGFB-D/PDGFRB 0.01 0.054 0.2 11 -10000 0 11
ABCC1 0.031 0.012 -10000 0 -0.063 8 8
FAS signaling pathway (CD95)

Figure S27.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S27.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPTAN1 -0.018 0.042 0.21 8 -0.19 12 20
RFC1 -0.022 0.035 0.17 2 -0.19 14 16
PRKDC -0.023 0.035 0.17 2 -0.19 14 16
RIPK1 0.03 0.013 -10000 0 -0.062 9 9
CASP7 -0.15 0.26 -10000 0 -0.59 132 132
FASLG/FAS/FADD/FAF1 -0.022 0.057 0.11 1 -0.12 124 125
MAP2K4 -0.059 0.12 0.34 2 -0.24 128 130
mol:ceramide -0.014 0.061 -10000 0 -0.16 21 21
GSN -0.019 0.043 0.21 8 -0.19 13 21
FASLG/FAS/FADD/FAF1/Caspase 8 -0.027 0.062 0.14 1 -0.12 128 129
FAS 0.013 0.03 -10000 0 -0.064 55 55
BID -0.031 0.014 0.2 1 -10000 0 1
MAP3K1 -0.1 0.18 0.42 1 -0.39 135 136
MAP3K7 0.031 0.008 -10000 0 -0.063 1 1
RB1 -0.02 0.034 0.17 2 -0.19 13 15
CFLAR 0.032 0.009 -10000 0 -0.061 5 5
HGF/MET 0.037 0.037 -10000 0 -0.047 28 28
ARHGDIB -0.02 0.044 0.21 9 -0.2 11 20
FADD 0.032 0.006 -10000 0 -0.062 1 1
actin filament polymerization 0.019 0.043 0.19 13 -0.21 8 21
NFKB1 0.014 0.072 -10000 0 -0.62 6 6
MAPK8 -0.064 0.12 0.42 2 -0.24 124 126
DFFA -0.02 0.038 0.2 4 -0.2 13 17
DNA fragmentation during apoptosis -0.021 0.036 0.19 3 -0.2 13 16
FAS/FADD/MET 0.026 0.04 -10000 0 -0.048 53 53
CFLAR/RIP1 0.045 0.017 -10000 0 -0.048 14 14
FAIM3 0.031 0.007 -10000 0 -0.063 1 1
FAF1 0.031 0.006 -10000 0 -10000 0 0
PARP1 -0.023 0.037 0.22 2 -0.19 15 17
DFFB -0.021 0.036 0.19 3 -0.2 13 16
CHUK 0.005 0.067 -10000 0 -0.59 6 6
FASLG 0.032 0.005 -10000 0 -10000 0 0
FAS/FADD 0.024 0.034 -10000 0 -0.051 56 56
HGF 0.022 0.016 -10000 0 -0.063 1 1
LMNA -0.027 0.034 0.19 2 -0.18 13 15
CASP6 -0.023 0.033 0.17 2 -0.19 12 14
CASP10 0.032 0.002 -10000 0 -10000 0 0
CASP3 -0.016 0.033 0.16 1 -0.22 9 10
PTPN13 0.027 0.021 -10000 0 -0.063 26 26
CASP8 -0.03 0.007 0.053 1 -0.058 9 10
IL6 -0.025 0.092 0.29 1 -0.52 7 8
MET 0.022 0.016 -10000 0 -0.063 2 2
ICAD/CAD -0.026 0.04 0.25 4 -0.19 13 17
FASLG/FAS/FADD/FAF1/Caspase 10 -0.015 0.061 -10000 0 -0.16 21 21
activation of caspase activity by cytochrome c -0.031 0.014 0.2 1 -10000 0 1
PAK2 -0.02 0.041 0.21 7 -0.19 12 19
BCL2 0.032 0.006 -10000 0 -10000 0 0
Caspase cascade in apoptosis

Figure S28.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S28.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TOP1 -0.016 0.097 0.3 1 -0.33 25 26
ACTA1 -0.045 0.088 0.4 1 -0.3 33 34
NUMA1 -0.014 0.086 0.3 1 -0.31 28 29
SPTAN1 -0.045 0.091 0.21 8 -0.33 29 37
LIMK1 -0.002 0.1 0.18 75 -0.31 22 97
BIRC3 0.026 0.023 -10000 0 -0.063 30 30
BIRC2 0.032 0.004 -10000 0 -10000 0 0
BAX 0.03 0.013 -10000 0 -0.063 6 6
CASP10 -0.02 0.013 -10000 0 -0.051 19 19
CRMA 0 0 -10000 0 -0.001 2 2
XIAP 0 0 0.001 2 -0.001 9 11
PTK2 -0.015 0.086 0.3 1 -0.32 23 24
DIABLO 0.032 0.004 -10000 0 -10000 0 0
apoptotic nuclear changes -0.041 0.094 0.21 8 -0.33 29 37
response to UV 0 0 -10000 0 -10000 0 0
CRADD 0.032 0.004 -10000 0 -10000 0 0
GSN -0.048 0.091 0.21 8 -0.33 29 37
MADD 0.031 0.006 -10000 0 0 21 21
TFAP2A 0.03 0.09 -10000 0 -0.71 6 6
BID -0.004 0.014 -10000 0 -0.13 5 5
MAP3K1 -0.009 0.056 -10000 0 -0.42 6 6
TRADD 0.032 0.004 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
APAF-1/Pro-Caspase 9 0.046 0.012 -10000 0 -0.05 3 3
mol:Activated DNA 0 0 -10000 0 -10000 0 0
ARHGDIB -0.049 0.092 0.2 10 -0.32 31 41
CASP9 0.031 0.009 -10000 0 -0.063 3 3
DNA repair 0.026 0.06 0.18 30 -0.14 1 31
neuron apoptosis 0.021 0.069 -10000 0 -0.62 5 5
mol:NAD 0 0 -10000 0 -10000 0 0
DNA fragmentation during apoptosis -0.034 0.093 0.28 3 -0.32 33 36
APAF1 0.032 0.004 -10000 0 -10000 0 0
CASP6 0.013 0.1 0.36 1 -0.92 4 5
TRAF2 0.031 0.006 -10000 0 -10000 0 0
ICAD/CAD -0.053 0.091 0.31 5 -0.34 28 33
CASP7 -0.055 0.1 -10000 0 -0.22 131 131
KRT18 0.013 0.059 -10000 0 -0.49 5 5
apoptosis -0.048 0.1 0.6 1 -0.34 29 30
DFFA -0.049 0.089 0.26 3 -0.34 28 31
DFFB -0.049 0.089 0.26 3 -0.33 29 32
PARP1 -0.026 0.061 0.14 1 -0.18 30 31
actin filament polymerization -0.006 0.1 0.29 22 -0.17 75 97
TNF 0.032 0.006 -10000 0 -0.063 2 2
CYCS 0 0.029 0.25 1 -0.22 2 3
SATB1 0.017 0.1 0.37 2 -0.83 4 6
SLK -0.052 0.09 0.42 1 -0.32 33 34
p15 BID/BAX -0.011 0.066 0.21 1 -0.2 39 40
CASP2 0.041 0.088 0.2 116 -0.16 4 120
JNK cascade 0.009 0.056 0.42 6 -10000 0 6
CASP3 -0.047 0.091 0.24 1 -0.31 35 36
LMNB2 0.047 0.082 0.24 11 -0.35 2 13
RIPK1 0.03 0.013 -10000 0 -0.063 9 9
CASP4 0.013 0.038 -10000 0 -0.063 101 101
Mammalian IAPs/DIABLO 0.054 0.028 -10000 0 -0.042 37 37
negative regulation of DNA binding 0.03 0.089 -10000 0 -0.65 7 7
stress fiber formation -0.052 0.089 0.42 1 -0.32 32 33
GZMB -0.018 0.012 -10000 0 -0.052 19 19
CASP1 -0.011 0.034 -10000 0 -0.053 186 186
LMNB1 0.038 0.1 0.24 13 -0.37 10 23
APP 0.021 0.069 -10000 0 -0.63 5 5
TNFRSF1A 0 0.044 -10000 0 -0.063 165 165
response to stress 0 0 0.001 6 -0.001 21 27
CASP8 -0.012 0.004 -10000 0 -0.039 9 9
VIM -0.042 0.099 0.43 1 -0.34 29 30
LMNA 0.05 0.081 0.24 13 -0.31 3 16
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD/PIDD 0.002 0.039 -10000 0 -0.17 11 11
LRDD 0 0 -10000 0 -10000 0 0
SREBF1 -0.051 0.086 0.2 2 -0.34 29 31
APAF-1/Caspase 9 0.021 0.073 -10000 0 -0.62 6 6
nuclear fragmentation during apoptosis -0.014 0.085 0.29 1 -0.3 28 29
CFL2 0.006 0.1 0.17 75 -0.29 22 97
GAS2 -0.052 0.087 0.2 2 -0.31 33 35
positive regulation of apoptosis 0.049 0.09 0.2 38 -0.33 6 44
PRF1 0.022 0.019 -10000 0 -0.063 12 12
PDGFR-alpha signaling pathway

Figure S29.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S29.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRA 0.015 0.027 -10000 0 -0.032 103 103
PDGF/PDGFRA/CRKL 0.037 0.021 -10000 0 -0.051 5 5
positive regulation of JUN kinase activity 0.039 0.035 -10000 0 -0.044 42 42
CRKL 0.031 0.007 -10000 0 -10000 0 0
PDGF/PDGFRA/Caveolin-3 0.038 0.021 -10000 0 -0.051 5 5
AP1 -0.027 0.073 0.14 58 -0.15 3 61
mol:IP3 -0.022 0.014 0.033 4 -0.066 2 6
PLCG1 -0.022 0.015 0.033 4 -0.066 2 6
PDGF/PDGFRA/alphaV Integrin 0.036 0.026 -10000 0 -0.053 20 20
RAPGEF1 0.031 0.006 -10000 0 -10000 0 0
CRK 0.032 0.005 -10000 0 -10000 0 0
mol:Ca2+ -0.022 0.014 0.033 4 -0.066 2 6
CAV3 0.032 0.004 -10000 0 -10000 0 0
CAV1 -0.018 0.041 -10000 0 -0.063 218 218
SHC/Grb2/SOS1 0.041 0.036 -10000 0 -0.044 42 42
PDGF/PDGFRA/Shf 0.019 0.011 -10000 0 -0.04 6 6
FOS -0.04 0.048 0.17 4 -0.12 98 102
JUN -0.026 0.021 0.041 5 -10000 0 5
oligodendrocyte development 0.036 0.025 -10000 0 -0.053 20 20
GRB2 0.032 0.006 -10000 0 -10000 0 0
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
mol:DAG -0.022 0.014 0.033 4 -0.066 2 6
PDGF/PDGFRA 0.015 0.027 -10000 0 -0.032 103 103
actin cytoskeleton reorganization 0.036 0.022 -10000 0 -0.05 4 4
SRF -0.021 0.007 0.02 1 -10000 0 1
SHC1 0.024 0.026 -10000 0 -0.063 40 40
PI3K 0.045 0.034 -10000 0 -0.05 22 22
PDGF/PDGFRA/Crk/C3G 0.049 0.031 -10000 0 -0.04 18 18
JAK1 -0.018 0.014 0.022 25 -0.052 5 30
ELK1/SRF -0.01 0.059 0.13 72 -10000 0 72
SHB 0.03 0.009 -10000 0 -10000 0 0
SHF 0 0 -10000 0 -10000 0 0
CSNK2A1 0.026 0.024 -10000 0 -0.033 17 17
GO:0007205 -0.016 0.011 -10000 0 -0.057 5 5
SOS1 0 0 -10000 0 -10000 0 0
Ras protein signal transduction 0.039 0.035 -10000 0 -0.044 42 42
PDGF/PDGFRA/SHB 0.036 0.022 -10000 0 -0.05 4 4
PDGF/PDGFRA/Caveolin-1 -0.009 0.038 -10000 0 -0.054 186 186
ITGAV 0.03 0.016 -10000 0 -0.063 15 15
ELK1 -0.022 0.015 0.026 3 -0.07 2 5
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
PDGF/PDGFRA/Crk 0.038 0.021 -10000 0 -0.05 5 5
JAK-STAT cascade -0.018 0.014 0.022 25 -0.052 5 30
cell proliferation 0.019 0.011 -10000 0 -0.04 6 6
HIV-1 Nef: Negative effector of Fas and TNF-alpha

Figure S30.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S30.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BAG4 0.032 0.004 -10000 0 -10000 0 0
Caspase 8 (4 units) -0.005 0.078 0.15 3 -0.17 35 38
NEF 0.002 0.001 -10000 0 -10000 0 0
NFKBIA 0.027 0.017 -10000 0 -0.035 27 27
BIRC3 -0.033 0.021 0.17 3 -10000 0 3
CYCS 0.004 0.068 0.17 61 -0.12 3 64
RIPK1 0.03 0.013 -10000 0 -0.063 9 9
CD247 0.033 0.008 -10000 0 -0.063 2 2
MAP2K7 -0.007 0.088 -10000 0 -0.42 6 6
protein ubiquitination 0.002 0.05 0.2 7 -0.24 8 15
CRADD 0.032 0.004 -10000 0 -10000 0 0
DAXX 0.032 0.005 -10000 0 -0.063 1 1
FAS 0.013 0.03 -10000 0 -0.063 55 55
BID -0.018 0.044 0.16 3 -0.1 94 97
NF-kappa-B/RelA/I kappa B alpha 0.054 0.042 -10000 0 -0.062 35 35
TRADD 0.032 0.004 -10000 0 -10000 0 0
MAP3K5 0.03 0.009 -10000 0 -10000 0 0
CFLAR 0.032 0.01 -10000 0 -0.063 5 5
FADD 0.032 0.006 -10000 0 -0.063 1 1
NF-kappa-B/RelA/I kappa B alpha/ubiquitin 0.054 0.042 -10000 0 -0.062 35 35
MAPK8 -0.004 0.085 0.54 1 -0.39 7 8
APAF1 0.032 0.004 -10000 0 -10000 0 0
TRAF1 0.031 0.008 -10000 0 -0.063 1 1
TRAF2 0.031 0.006 -10000 0 -10000 0 0
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG 0.007 0.024 0.18 3 -0.13 6 9
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP1/cIAP2/TRAF1/TRAF2/Ask1/RAIDD 0.014 0.05 -10000 0 -0.23 10 10
CHUK 0.003 0.05 0.2 7 -0.24 8 15
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 0.038 0.071 -10000 0 -10000 0 0
TCRz/NEF 0.028 0.006 -10000 0 -0.039 2 2
TNF 0.032 0.006 -10000 0 -0.063 2 2
FASLG -0.016 0.003 -10000 0 -10000 0 0
NFKB1 0.028 0.018 -10000 0 -0.037 32 32
TNFR1A/BAG4/TNF-alpha 0.025 0.054 -10000 0 -0.048 165 165
CASP6 0.008 0.086 -10000 0 -0.44 5 5
CASP7 -0.06 0.11 0.19 3 -0.24 130 133
RELA 0.029 0.016 -10000 0 -0.033 30 30
CASP2 0.023 0.015 -10000 0 -10000 0 0
CASP3 -0.03 0.071 0.2 3 -0.24 23 26
TNFRSF1A 0 0.044 -10000 0 -0.063 165 165
TNFR1A/BAG4 0.014 0.045 -10000 0 -0.05 164 164
CASP8 0.031 0.013 -10000 0 -0.063 9 9
CASP9 0.031 0.009 -10000 0 -0.063 3 3
MAP3K14 0.01 0.054 0.16 2 -0.25 10 12
APAF-1/Caspase 9 -0.017 0.071 0.13 65 -0.16 7 72
BCL2 -0.016 0.086 0.33 3 -0.37 7 10
Signaling events mediated by the Hedgehog family

Figure S31.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S31.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB2 0.018 0.027 0.16 9 -0.083 14 23
IHH 0.038 0.021 0.11 17 -0.045 7 24
SHH Np/Cholesterol/GAS1 0.014 0.02 -10000 0 -0.041 37 37
LRPAP1 0.032 0.003 -10000 0 -10000 0 0
dorsoventral neural tube patterning -0.013 0.02 0.041 37 -10000 0 37
SMO/beta Arrestin2 0.066 0.056 0.16 120 -10000 0 120
SMO 0.014 0.019 0.14 3 -10000 0 3
AKT1 0.003 0.083 -10000 0 -0.33 21 21
ARRB2 0.032 0.005 -10000 0 -10000 0 0
BOC 0 0 -10000 0 -10000 0 0
ADRBK1 0.032 0.004 -10000 0 -10000 0 0
heart looping 0.014 0.019 0.14 3 -10000 0 3
STIL 0.024 0.085 0.17 125 -10000 0 125
DHH N/PTCH2 0.024 0.003 -10000 0 0 10 10
DHH N/PTCH1 0.017 0.014 -10000 0 -0.065 1 1
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
DHH 0 0 -10000 0 -10000 0 0
PTHLH 0.015 0.024 0.15 8 -0.094 6 14
determination of left/right symmetry 0.014 0.019 0.14 3 -10000 0 3
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
skeletal system development 0.015 0.024 0.15 8 -0.093 6 14
IHH N/Hhip 0.025 0.012 0.071 17 -0.023 1 18
DHH N/Hhip 0 0 -10000 0 -10000 0 0
mol:Cholesterol 0 0 -10000 0 -10000 0 0
heart development 0.014 0.019 0.14 3 -10000 0 3
pancreas development 0 0 -10000 0 -10000 0 0
HHAT 0.032 0.006 -10000 0 -10000 0 0
PI3K 0.039 0.023 -10000 0 -0.05 16 16
EntrezGene:84976 0 0 -10000 0 -10000 0 0
GAS1 0.021 0.03 -10000 0 -0.063 55 55
somite specification 0.014 0.019 0.14 3 -10000 0 3
SHH Np/Cholesterol/PTCH1 0.014 0.017 -10000 0 -10000 0 0
SHH Np/Cholesterol/PTCH2 0.018 0.014 -10000 0 -0.031 4 4
SHH Np/Cholesterol/Megalin 0.018 0.014 -10000 0 -0.033 5 5
SHH -0.015 0.011 0 167 -10000 0 167
catabolic process 0.02 0.017 -10000 0 -0.076 1 1
SMO/Vitamin D3 0.016 0.032 0.18 14 -10000 0 14
SHH Np/Cholesterol/Hhip -0.011 0.007 0 163 -10000 0 163
LRP2 0.032 0.005 -10000 0 -0.063 1 1
receptor-mediated endocytosis 0.012 0.027 0.15 13 -10000 0 13
SHH Np/Cholesterol/BOC -0.011 0.007 0 163 -10000 0 163
SHH Np/Cholesterol/CDO 0.018 0.014 -10000 0 -10000 0 0
mesenchymal cell differentiation 0.011 0.007 -10000 0 0 163 163
mol:Vitamin D3 0.041 0.096 0.19 146 -10000 0 146
IHH N/PTCH2 0.05 0.012 0.11 8 -0.036 1 9
CDON 0.032 0.004 -10000 0 -10000 0 0
IHH N/PTCH1 0.036 0.021 -10000 0 -0.063 13 13
Megalin/LRPAP1 0.047 0.007 -10000 0 -0.05 1 1
PTCH2 0.032 0.005 -10000 0 -10000 0 0
SHH Np/Cholesterol -0.011 0.007 -10000 0 -10000 0 0
PTCH1 0.02 0.017 -10000 0 -0.076 1 1
HHIP 0 0 -10000 0 -10000 0 0
JNK signaling in the CD4+ TCR pathway

Figure S32.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S32.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
LAT/GRAP2/SLP76/HPK1 0.061 0.047 -10000 0 -0.058 1 1
MAP4K1 0.031 0.008 -10000 0 -0.063 1 1
MAP3K8 0.018 0.026 -10000 0 -0.063 37 37
PRKCB 0 0 -10000 0 -10000 0 0
DBNL 0 0 -10000 0 -10000 0 0
CRKL 0.031 0.007 -10000 0 -10000 0 0
MAP3K1 0.001 0.034 0.076 14 -0.12 28 42
JUN -0.12 0.23 0.23 2 -0.52 121 123
MAP3K7 0.002 0.033 0.076 14 -0.12 24 38
GRAP2 0.03 0.008 -10000 0 -10000 0 0
CRK 0.032 0.005 -10000 0 -10000 0 0
MAP2K4 -0.02 0.063 0.15 5 -0.22 32 37
LAT 0.032 0.005 -10000 0 -0.063 1 1
LCP2 0.026 0.022 -10000 0 -0.063 29 29
MAPK8 -0.12 0.24 -10000 0 -0.55 121 121
LAT/GRAP2/SLP76/HPK1/HIP-55/CRK family 0.015 0.035 0.088 14 -0.14 16 30
LAT/GRAP2/SLP76/HPK1/HIP-55 0.057 0.044 -10000 0 -0.054 1 1
Glypican 1 network

Figure S33.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S33.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GPC1/FGF2 dimer/FGFR1 dimer 0.061 0.022 -10000 0 -0.048 10 10
fibroblast growth factor receptor signaling pathway 0.06 0.022 -10000 0 -0.048 10 10
LAMA1 0 0 -10000 0 -10000 0 0
PRNP 0.028 0.011 -10000 0 -10000 0 0
GPC1/SLIT2 0.03 0.024 -10000 0 -0.05 5 5
SMAD2 -0.027 0.029 0.17 10 -10000 0 10
GPC1/PrPc/Cu2+ 0.037 0.018 -10000 0 -0.04 7 7
GPC1/Laminin alpha1 0.023 0.008 -10000 0 -0.039 7 7
TDGF1 0.031 0.008 -10000 0 -0.063 2 2
CRIPTO/GPC1 0.045 0.016 -10000 0 -0.05 9 9
APP/GPC1 0.046 0.014 -10000 0 -0.05 7 7
mol:NO 0 0 -10000 0 -10000 0 0
YES1 -0.028 0.011 -10000 0 -0.069 4 4
FLT1 0.03 0.008 -10000 0 -10000 0 0
GPC1/TGFB/TGFBR1/TGFBR2 0.059 0.026 -10000 0 -0.041 27 27
SERPINC1 0.032 0.006 -10000 0 -0.063 1 1
FYN -0.024 0.009 -10000 0 -10000 0 0
FGR -0.026 0.008 -10000 0 -10000 0 0
positive regulation of MAPKKK cascade -0.007 0.06 0.18 32 -0.2 6 38
SLIT2 0.021 0.017 -10000 0 -0.063 3 3
GPC1/NRG 0.046 0.014 -10000 0 -0.05 7 7
NRG1 0.032 0.004 -10000 0 -10000 0 0
GPC1/VEGF165 homodimer/VEGFR1 homodimer 0 0.056 -10000 0 -0.049 276 276
LYN -0.028 0.01 -10000 0 -0.049 67 67
mol:Spermine -0.012 0.003 -10000 0 -0.039 7 7
cell growth 0.06 0.022 -10000 0 -0.048 10 10
BMP signaling pathway -0.031 0.012 0.063 7 -10000 0 7
SRC -0.024 0.008 -10000 0 -10000 0 0
TGFBR1 0.032 0.006 -10000 0 0 16 16
mol:Cu2+ 0 0 -10000 0 -10000 0 0
PLA2G2A -0.002 0.045 -10000 0 -0.063 179 179
GPC1 0.031 0.012 -10000 0 -0.063 7 7
TGFBR1 (dimer) 0.032 0.006 -10000 0 0 16 16
VEGFA -0.019 0.047 -10000 0 -0.063 274 274
BLK -0.025 0.007 -10000 0 -0.048 8 8
HCK -0.028 0.013 -10000 0 -0.049 84 84
FGF2 0.032 0.007 -10000 0 -0.063 2 2
FGFR1 0.032 0.005 -10000 0 -0.063 1 1
VEGFR1 homodimer 0.03 0.008 -10000 0 -10000 0 0
TGFBR2 0.031 0.01 -10000 0 -0.063 5 5
cell death 0.045 0.014 -10000 0 -0.049 7 7
ATIII/GPC1 0.046 0.014 -10000 0 -0.05 8 8
PLA2G2A/GPC1 0.011 0.047 -10000 0 -0.05 182 182
LCK -0.026 0.007 -10000 0 -0.05 11 11
neuron differentiation 0.046 0.014 -10000 0 -0.049 7 7
PrPc/Cu2+ 0.021 0.008 -10000 0 -10000 0 0
APP 0.032 0.005 -10000 0 -10000 0 0
TGFBR2 (dimer) 0.031 0.01 -10000 0 -0.063 5 5
Signaling mediated by p38-alpha and p38-beta

Figure S34.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S34.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTGS2 0.014 0.026 0.077 3 -0.09 26 29
MKNK1 0.032 0.005 -10000 0 -10000 0 0
MAPK14 0.032 0.024 0.091 5 -0.067 26 31
ATF2/c-Jun 0.004 0.041 -10000 0 -0.11 51 51
MAPK11 0.029 0.025 0.09 4 -0.067 25 29
MITF 0.016 0.017 0.082 5 -0.043 28 33
MAPKAPK5 0.016 0.016 0.076 3 -0.043 26 29
KRT8 0.013 0.021 0.076 3 -0.045 45 48
MAPKAPK3 0.032 0.007 -10000 0 -0.063 1 1
MAPKAPK2 0.032 0.006 -10000 0 -10000 0 0
p38alpha-beta/CK2 0.04 0.033 -10000 0 -0.083 25 25
CEBPB 0.014 0.019 0.082 3 -0.05 30 33
SLC9A1 0.016 0.016 0.081 1 -0.043 26 27
mol:GDP 0 0 -10000 0 -10000 0 0
ATF2 0.017 0.02 0.11 9 -0.046 25 34
p38alpha-beta/MNK1 0.053 0.036 -10000 0 -0.07 25 25
JUN -0.001 0.039 -10000 0 -0.11 51 51
PPARGC1A 0.016 0.017 0.082 5 -0.044 28 33
USF1 0.012 0.016 0.077 5 -0.045 26 31
RAB5/GDP/GDI1 0.013 0.048 -10000 0 -0.12 46 46
NOS2 0.012 0.015 0.077 5 -0.044 26 31
DDIT3 0.014 0.018 0.074 2 -0.045 28 30
RAB5A 0.032 0.004 -10000 0 -10000 0 0
HSPB1 0.059 0.12 0.27 121 -10000 0 121
p38alpha-beta/HBP1 0.038 0.04 -10000 0 -0.071 20 20
CREB1 0.004 0.057 -10000 0 -0.2 36 36
RAB5/GDP 0.024 0.003 -10000 0 -10000 0 0
EIF4E -0.031 0.029 0.22 6 -10000 0 6
RPS6KA4 0.016 0.017 0.082 5 -0.043 26 31
PLA2G4A -0.037 0.024 0.21 3 -10000 0 3
GDI1 0.016 0.015 0.082 5 -0.044 17 22
TP53 -0.015 0.017 0.063 6 -0.071 25 31
RPS6KA5 0.016 0.017 0.082 5 -0.043 26 31
ESR1 0.016 0.017 0.082 5 -0.043 25 30
HBP1 0.023 0.015 -10000 0 -10000 0 0
MEF2C 0.014 0.015 0.082 3 -0.044 17 20
MEF2A 0.016 0.017 0.082 5 -0.043 26 31
EIF4EBP1 -0.009 0.058 -10000 0 -0.21 35 35
KRT19 0.014 0.021 0.082 5 -0.044 45 50
ELK4 0.016 0.016 0.076 3 -0.043 25 28
ATF6 0.016 0.016 0.076 3 -0.043 25 28
ATF1 0.001 0.058 -10000 0 -0.19 38 38
p38alpha-beta/MAPKAPK2 0.053 0.036 -10000 0 -0.07 24 24
p38alpha-beta/MAPKAPK3 0.053 0.037 -10000 0 -0.07 25 25
Paxillin-independent events mediated by a4b1 and a4b7

Figure S35.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S35.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.004 0.043 -10000 0 -0.084 113 113
CRKL 0.031 0.007 -10000 0 -10000 0 0
Rac1/GDP 0.017 0.011 -10000 0 -10000 0 0
DOCK1 0.023 0.015 -10000 0 -10000 0 0
ITGA4 0.031 0.01 -10000 0 -0.063 5 5
alpha4/beta7 Integrin/MAdCAM1 0.074 0.031 -10000 0 -0.069 2 2
EPO 0.023 0.015 -10000 0 -10000 0 0
alpha4/beta7 Integrin 0.046 0.013 -10000 0 -0.06 5 5
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.032 0.005 -10000 0 -10000 0 0
alpha4/beta1 Integrin 0.036 0.022 -10000 0 -0.05 4 4
EPO/EPOR (dimer) 0.033 0.023 -10000 0 -10000 0 0
lamellipodium assembly -0.006 0.082 -10000 0 -0.3 30 30
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
PI3K 0.039 0.023 -10000 0 -0.05 16 16
ARF6 0.031 0.008 -10000 0 -10000 0 0
JAK2 0.009 0.028 -10000 0 -0.091 31 31
PXN 0.032 0.003 -10000 0 -10000 0 0
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
MADCAM1 0.031 0.007 -10000 0 -10000 0 0
cell adhesion 0.072 0.03 -10000 0 -0.069 2 2
CRKL/CBL 0.045 0.012 -10000 0 -10000 0 0
ITGB1 0.025 0.014 -10000 0 -10000 0 0
SRC -0.041 0.02 0.17 2 -10000 0 2
ITGB7 0.032 0.008 -10000 0 -0.063 2 2
RAC1 0.023 0.015 -10000 0 -10000 0 0
alpha4/beta1 Integrin/VCAM1 -0.02 0.05 -10000 0 -0.049 375 375
p130Cas/Crk/Dock1 -0.048 0.023 0.18 3 -10000 0 3
VCAM1 -0.03 0.045 -10000 0 -0.063 333 333
RHOA 0.032 0.006 -10000 0 -10000 0 0
alpha4/beta1 Integrin/Paxillin/GIT1 0.054 0.053 -10000 0 -0.058 1 1
BCAR1 -0.037 0.035 0.27 4 -10000 0 4
EPOR 0.031 0.006 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
CBL 0.032 0.004 -10000 0 -10000 0 0
GIT1 0.032 0.004 -10000 0 -10000 0 0
Rac1/GTP -0.007 0.084 -10000 0 -0.31 30 30
TCGA08_rtk_signaling

Figure S36.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S36.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRA 0.026 0.015 -10000 0 -0.063 6 6
HRAS 0.031 0.007 -10000 0 -10000 0 0
EGFR 0.012 0.018 -10000 0 -0.063 6 6
AKT 0.12 0.092 0.22 197 -0.14 1 198
FOXO3 0.03 0.008 -10000 0 -10000 0 0
AKT1 0.03 0.008 -10000 0 -10000 0 0
FOXO1 0.028 0.016 -10000 0 -0.063 11 11
AKT3 0.031 0.007 -10000 0 -10000 0 0
FOXO4 0.032 0.002 -10000 0 -10000 0 0
MET 0.022 0.016 -10000 0 -0.063 2 2
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
PIK3CB 0.032 0.005 -10000 0 -10000 0 0
NRAS 0.009 0.041 -10000 0 -0.063 125 125
PIK3CG 0.023 0.015 -10000 0 -10000 0 0
PIK3R3 0.032 0.006 -10000 0 -0.063 1 1
PIK3R2 0.031 0.006 -10000 0 -10000 0 0
NF1 0.032 0.003 -10000 0 -10000 0 0
RAS 0.006 0.024 -10000 0 -0.084 9 9
ERBB2 0.032 0.003 -10000 0 -10000 0 0
proliferation/survival/translation -0.044 0.07 0.3 9 -0.21 15 24
PI3K 0.049 0.072 0.17 95 -10000 0 95
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
KRAS 0.031 0.008 -10000 0 -10000 0 0
FOXO 0.13 0.082 0.21 194 -10000 0 194
AKT2 0.031 0.006 -10000 0 -10000 0 0
PTEN 0.023 0.016 -10000 0 -0.063 2 2
Arf6 trafficking events

Figure S37.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S37.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SLC2A4 0.032 0.005 -10000 0 -10000 0 0
CLTC 0.008 0.089 -10000 0 -0.34 29 29
calcium ion-dependent exocytosis 0.022 0.045 0.091 109 -0.13 15 124
Dynamin 2/GTP 0.022 0.012 -10000 0 -0.023 28 28
EXOC4 0 0 -10000 0 -10000 0 0
CD59 0.006 0.075 -10000 0 -0.28 28 28
CPE -0.015 0.007 0 82 -10000 0 82
CTNNB1 0.032 0.005 -10000 0 -10000 0 0
membrane fusion 0.026 0.044 0.093 126 -0.1 13 139
CTNND1 -0.021 0.006 -10000 0 -10000 0 0
DNM2 0.031 0.006 -10000 0 -10000 0 0
mol:PI-4-5-P2 0.012 0.055 0.13 9 -0.17 28 37
TSHR -0.017 0.005 0 40 -0.04 4 44
INS 0.004 0.095 -10000 0 -0.46 19 19
BIN1 0.03 0.009 -10000 0 -10000 0 0
mol:Choline 0.026 0.044 0.093 126 -0.1 13 139
growth hormone secretagogue receptor activity 0 0 -10000 0 -10000 0 0
mol:GDP -0.008 0.002 -10000 0 -10000 0 0
membrane depolarization 0 0 -10000 0 -10000 0 0
ARF6 0.031 0.008 -10000 0 -10000 0 0
mol:Ca2+ 0.021 0.012 -10000 0 -0.023 28 28
JUP 0.005 0.072 -10000 0 -0.28 27 27
ASAP2/amphiphysin II 0.035 0.018 -10000 0 -0.023 27 27
ARF6/GTP 0.023 0.006 -10000 0 0 29 29
CDH1 0.006 0.072 -10000 0 -0.28 27 27
clathrin-independent pinocytosis 0.023 0.006 -10000 0 0 29 29
MAPK8IP3 0.032 0.004 -10000 0 -10000 0 0
positive regulation of endocytosis 0.023 0.006 -10000 0 0 29 29
EXOC2 0.032 0.004 -10000 0 -10000 0 0
substrate adhesion-dependent cell spreading 0.003 0.04 -10000 0 -0.13 34 34
insulin receptor binding 0 0 -10000 0 -10000 0 0
SPAG9 0.032 0.005 -10000 0 -0.063 1 1
regulation of calcium-dependent cell-cell adhesion -0.033 0.076 0.27 28 -10000 0 28
positive regulation of phagocytosis -0.016 0.006 0 63 -10000 0 63
ARF6/GTP/JIP3 0.041 0.011 -10000 0 -10000 0 0
ACAP1 0.027 0.042 0.091 126 -0.091 13 139
mol:GTP 0 0 -10000 0 -10000 0 0
CHRM2 0.001 0.066 -10000 0 -0.29 21 21
clathrin heavy chain/ACAP1 0.017 0.077 0.18 9 -0.25 28 37
JIP4/KLC1 0.041 0.033 -10000 0 -0.035 25 25
EXOC1 0.03 0.009 -10000 0 -0.063 1 1
exocyst 0.003 0.041 -10000 0 -0.13 34 34
RALA/GTP 0.015 0.014 -10000 0 -0.039 11 11
ARF6/GTP/ARF6/GTP/JIP4/Dynactin Complex 0.041 0.011 -10000 0 -0.04 1 1
receptor recycling 0.023 0.006 -10000 0 0 29 29
CTNNA1 -0.021 0.005 -10000 0 -10000 0 0
NME1 -0.008 0.002 -10000 0 -10000 0 0
clathrin coat assembly 0.009 0.088 0.18 1 -0.33 29 30
IL2RA -0.003 0.08 -10000 0 -0.33 26 26
VAMP3 -0.016 0.006 0 63 -10000 0 63
GLUT4/clathrin heavy chain/ACAP1 0.034 0.075 -10000 0 -0.25 28 28
EXOC6 0 0 -10000 0 -10000 0 0
PLD1 0.006 0.012 -10000 0 -0.052 14 14
PLD2 0.006 0.011 -10000 0 -0.054 11 11
EXOC5 0.028 0.018 -10000 0 -0.063 15 15
PIP5K1C 0.011 0.051 0.12 4 -0.17 26 30
SDC1 0.003 0.074 -10000 0 -0.28 28 28
ARF6/GDP 0.023 0.006 -10000 0 0 29 29
EXOC7 0.032 0.004 -10000 0 -10000 0 0
E-cadherin/beta catenin 0.035 0.079 -10000 0 -0.28 28 28
mol:Phosphatidic acid 0.026 0.044 0.093 126 -0.1 13 139
endocytosis -0.034 0.018 0.023 27 -10000 0 27
SCAMP2 0.032 0.005 -10000 0 -10000 0 0
ADRB2 0.003 0.085 0.22 2 -0.32 29 31
EXOC3 0.032 0.006 -10000 0 -10000 0 0
ASAP2 0 0 -10000 0 -10000 0 0
Dynamin 2/GDP 0.019 0.011 -10000 0 -0.023 28 28
KLC1 0.023 0.015 -10000 0 -10000 0 0
AVPR2 0.004 0.086 0.2 4 -0.32 29 33
RALA 0.021 0.019 -10000 0 -0.063 11 11
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.02 0.076 0.22 2 -0.27 28 30
Plasma membrane estrogen receptor signaling

Figure S38.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S38.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GNB1/GNG2 0.045 0.031 -10000 0 -0.038 14 14
ER alpha/Gai/GDP/Gbeta gamma -0.089 0.13 -10000 0 -0.38 60 60
AKT1 -0.032 0.18 -10000 0 -0.71 31 31
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
E2/ER alpha (dimer)/PELP1/Src/PI3K -0.028 0.18 -10000 0 -0.73 31 31
mol:Ca2+ -0.004 0.045 0.17 18 -0.23 9 27
IGF1R 0.032 0.004 -10000 0 -10000 0 0
E2/ER alpha (dimer)/Striatin 0.041 0.011 -10000 0 -10000 0 0
SHC1 0.024 0.026 -10000 0 -0.063 40 40
apoptosis 0.03 0.17 0.68 31 -10000 0 31
RhoA/GTP -0.039 0.014 -10000 0 -0.076 1 1
E2/ER alpha (dimer)/PELP1/Src/p130 Cas -0.071 0.12 0.18 9 -0.3 61 70
regulation of stress fiber formation 0.045 0.044 -10000 0 -0.16 8 8
E2/ERA-ERB (dimer) 0.039 0.014 -10000 0 -10000 0 0
KRAS 0.031 0.008 -10000 0 -10000 0 0
G13/GTP 0.037 0.017 -10000 0 -0.025 32 32
pseudopodium formation -0.045 0.044 0.16 8 -10000 0 8
E2/ER alpha (dimer)/PELP1 0.04 0.012 -10000 0 -10000 0 0
GRB2 0.032 0.006 -10000 0 -10000 0 0
GNG2 0 0 -10000 0 -10000 0 0
GNAO1 0.003 0.009 -10000 0 -10000 0 0
HRAS 0.031 0.007 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
mol:NO -0.055 0.14 0.21 2 -0.46 38 40
E2/ER beta (dimer) 0.023 0.006 -10000 0 -10000 0 0
mol:GDP -0.005 0.058 0.13 5 -0.17 45 50
mol:NADP -0.055 0.14 0.21 2 -0.46 38 40
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
mol:IP3 -0.01 0.032 -10000 0 -0.24 9 9
IGF-1R heterotetramer 0.032 0.004 -10000 0 -10000 0 0
PLCB1 0.008 0.016 -10000 0 -0.23 1 1
PLCB2 0.009 0.016 -10000 0 -0.23 1 1
IGF1 0.032 0.009 -10000 0 -0.063 4 4
mol:L-citrulline -0.055 0.14 0.21 2 -0.46 38 40
RHOA 0.032 0.006 -10000 0 -10000 0 0
Gai/GDP -0.43 0.16 -10000 0 -0.48 450 450
JNK cascade 0.022 0.006 -10000 0 -10000 0 0
BCAR1 0 0 -10000 0 -10000 0 0
ESR2 0.03 0.008 -10000 0 -10000 0 0
GNAQ 0.031 0.006 -10000 0 -10000 0 0
ESR1 0.031 0.008 -10000 0 -10000 0 0
Gq family/GDP/Gbeta gamma 0.014 0.07 -10000 0 -0.26 21 21
E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 0.004 0.071 -10000 0 -0.58 5 5
E2/ER alpha (dimer)/PELP1/Src/p52 SHC -0.07 0.12 0.2 10 -0.3 61 71
GNAZ 0.027 0.013 -10000 0 -10000 0 0
E2/ER alpha (dimer) 0.023 0.006 -10000 0 -10000 0 0
STRN 0.032 0.002 -10000 0 -10000 0 0
GNAL 0.032 0.006 -10000 0 -10000 0 0
PELP1 0.032 0.005 -10000 0 -10000 0 0
MAPK11 -0.015 0.006 -10000 0 -10000 0 0
GNAI2 0.032 0.006 -10000 0 -10000 0 0
GNAI3 0.021 0.03 -10000 0 -0.063 58 58
GNAI1 0.019 0.016 -10000 0 -0.063 1 1
HBEGF -0.11 0.13 0.24 16 -0.34 63 79
cAMP biosynthetic process 0.03 0.021 -10000 0 -0.029 55 55
SRC -0.098 0.12 0.2 1 -0.36 62 63
PI3K 0.039 0.023 -10000 0 -0.05 16 16
GNB1 0.031 0.008 -10000 0 -10000 0 0
G13/GDP/Gbeta gamma 0.024 0.059 -10000 0 -0.15 46 46
SOS1 0 0 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1 -0.078 0.091 -10000 0 -0.25 69 69
Gs family/GTP 0.039 0.025 -10000 0 -0.036 15 15
EntrezGene:2778 0 0 -10000 0 -10000 0 0
RAS family/GTP 0.031 0.046 -10000 0 -0.043 119 119
vasodilation -0.053 0.13 0.21 2 -0.43 38 40
mol:DAG -0.01 0.032 -10000 0 -0.24 9 9
Gs family/GDP/Gbeta gamma -0.005 0.056 -10000 0 -0.16 46 46
MSN -0.051 0.039 0.16 8 -10000 0 8
Gq family/GTP 0.022 0.019 -10000 0 -0.24 1 1
mol:PI-3-4-5-P3 -0.026 0.18 -10000 0 -0.7 31 31
NRAS 0.009 0.041 -10000 0 -0.063 125 125
mol:E2 0 0 -10000 0 -10000 0 0
cell adhesion 0.053 0.13 0.43 38 -0.21 2 40
GRB2/SOS1 0.023 0.004 -10000 0 -10000 0 0
RhoA/GDP 0.017 0.063 0.14 5 -0.17 46 51
NOS3 -0.058 0.14 0.22 2 -0.48 38 40
GNA11 0.031 0.006 -10000 0 -10000 0 0
MAPKKK cascade -0.035 0.14 0.24 1 -0.49 35 36
E2/ER alpha (dimer)/PELP1/Src -0.07 0.12 0.21 11 -0.31 60 71
ruffle organization -0.045 0.044 0.16 8 -10000 0 8
ROCK2 -0.032 0.052 0.16 23 -10000 0 23
GNA14 0.031 0.009 -10000 0 -0.063 2 2
GNA15 0.03 0.013 -10000 0 -0.016 27 27
GNA13 0.032 0.007 -10000 0 -0.063 2 2
MMP9 -0.11 0.12 0.37 1 -0.35 60 61
MMP2 -0.11 0.12 0.19 1 -0.36 60 61
Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Figure S39.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S39.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SMAD4 0.01 0.04 -10000 0 -0.063 117 117
SMAD2 -0.021 0.058 0.14 1 -0.22 28 29
SMAD3 0.013 0.042 0.1 30 -0.097 35 65
SMAD3/SMAD4 0.026 0.056 -10000 0 -0.5 4 4
SMAD4/Ubc9/PIASy 0.037 0.048 -10000 0 -0.048 108 108
SMAD2/SMAD2/SMAD4 0.017 0.084 -10000 0 -0.19 38 38
PPM1A 0.031 0.008 -10000 0 -10000 0 0
CALM1 0.029 0.01 -10000 0 -10000 0 0
SMAD2/SMAD4 -0.014 0.063 -10000 0 -0.18 40 40
MAP3K1 0.032 0.006 -10000 0 -0.063 1 1
TRAP-1/SMAD4 0.024 0.041 -10000 0 -0.05 116 116
MAPK3 0.032 0.002 -10000 0 -10000 0 0
MAPK1 0.03 0.009 -10000 0 0 42 42
NUP214 0.031 0.007 -10000 0 0 22 22
CTDSP1 0.032 0.007 -10000 0 -0.063 3 3
CTDSP2 0.028 0.011 -10000 0 -10000 0 0
CTDSPL 0.032 0.005 -10000 0 -10000 0 0
KPNB1 0.032 0.003 -10000 0 -10000 0 0
TGFBRAP1 0.032 0.003 -10000 0 -10000 0 0
UBE2I 0.032 0.003 -10000 0 -10000 0 0
NUP153 0.032 0.005 -10000 0 -0.063 1 1
KPNA2 0.03 0.014 -10000 0 -0.063 11 11
PIAS4 0.032 0.006 -10000 0 -10000 0 0
Fc-epsilon receptor I signaling in mast cells

Figure S40.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S40.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PPAP2A 0.032 0.006 -10000 0 -0.063 1 1
LAT2 -0.015 0.03 0.13 3 -0.13 7 10
AP1 -0.031 0.11 -10000 0 -0.29 30 30
mol:PIP3 0.026 0.1 0.27 33 -0.18 1 34
IKBKB 0.016 0.074 0.21 33 -0.14 1 34
AKT1 -0.033 0.077 0.32 10 -10000 0 10
IKBKG 0.016 0.073 0.21 32 -0.14 1 33
MS4A2 0.035 0.005 0.069 1 -10000 0 1
mol:Sphingosine-1-phosphate 0 0 -10000 0 -10000 0 0
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
MAP3K1 -0.01 0.06 0.22 14 -0.21 5 19
mol:Ca2+ 0.025 0.09 0.23 37 -10000 0 37
LYN 0.02 0.032 0.086 1 -0.065 62 63
CBLB -0.015 0.036 0.15 6 -0.13 8 14
SHC1 0.024 0.026 -10000 0 -0.063 40 40
RasGAP/p62DOK 0.056 0.024 -10000 0 -0.042 21 21
positive regulation of cell migration 0 0 -10000 0 -10000 0 0
INPP5D 0 0 -10000 0 -10000 0 0
PLD2 -0.031 0.06 0.32 11 -10000 0 11
PTPN13 0.005 0.074 0.32 1 -0.57 5 6
PTPN11 0.032 0.01 -10000 0 -0.029 9 9
GO:0007205 0 0 -10000 0 -10000 0 0
regulation of mast cell degranulation -0.009 0.074 0.34 7 -0.28 5 12
SYK 0.024 0.025 -10000 0 -0.064 35 35
GRB2 0.032 0.006 -10000 0 -10000 0 0
LAT/PLCgamma1/GRB2/SLP76/GADs 0.013 0.066 0.18 18 -0.16 5 23
LAT -0.015 0.037 0.15 6 -0.13 8 14
PAK2 -0.006 0.061 0.22 15 -0.21 6 21
NFATC2 -0.012 0.005 -10000 0 -10000 0 0
HRAS -0.002 0.057 0.2 12 -0.2 8 20
GAB2 0.032 0.006 -10000 0 -10000 0 0
PLA2G1B 0.021 0.064 -10000 0 -0.81 2 2
Fc epsilon R1 0.009 0.058 -10000 0 -0.05 241 241
Antigen/IgE/Fc epsilon R1 0.011 0.055 -10000 0 -0.045 239 239
mol:GDP 0.003 0.051 0.18 16 -0.19 1 17
JUN 0.032 0.005 -10000 0 -10000 0 0
mol:Ca++ 0 0 -10000 0 -10000 0 0
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
FOS 0.007 0.04 -10000 0 -0.063 120 120
Antigen/IgE/Fc epsilon R1/LYN/SYK -0.007 0.036 0.12 3 -0.12 6 9
CHUK 0.007 0.068 0.2 29 -0.14 1 30
KLRG1 -0.012 0.026 0.085 2 -0.095 3 5
VAV1 -0.015 0.037 0.12 9 -0.13 9 18
calcium-dependent protein kinase C activity 0 0 -10000 0 -10000 0 0
CBL -0.014 0.036 0.15 6 -0.12 7 13
negative regulation of mast cell degranulation -0.013 0.027 0.076 2 -0.1 4 6
BTK 0.007 0.04 0.19 2 -10000 0 2
Fc epsilon R1/FcgammaRIIB/SHIP/RasGAP/p62DOK -0.008 0.029 -10000 0 -0.12 5 5
GAB2/PI3K/SHP2 -0.052 0.024 0.027 1 -0.093 1 2
Antigen/IgE/Fc epsilon R1/LYN/SYK/WIP -0.009 0.03 -10000 0 -0.083 35 35
RAF1 0.024 0.061 -10000 0 -0.89 2 2
Fc epsilon R1/FcgammaRIIB/SHIP 0.006 0.065 -10000 0 -0.063 122 122
FCER1G -0.014 0.049 -10000 0 -0.065 242 242
FCER1A 0.03 0.015 -10000 0 -0.06 12 12
Antigen/IgE/Fc epsilon R1/Fyn 0.008 0.062 -10000 0 -0.052 61 61
MAPK3 0.024 0.063 -10000 0 -0.82 2 2
MAPK1 0.014 0.07 -10000 0 -0.82 2 2
NFKB1 0.031 0.009 -10000 0 -0.063 4 4
MAPK8 -0.1 0.25 -10000 0 -0.52 122 122
DUSP1 0.029 0.017 -10000 0 -0.063 16 16
NF-kappa-B/RelA 0.007 0.051 0.13 26 -0.099 1 27
actin cytoskeleton reorganization 0.012 0.076 0.33 1 -0.59 5 6
mol:Glucocorticoid Dexamethasone 0 0 -10000 0 -10000 0 0
PI3K 0.001 0.066 0.2 16 -0.19 7 23
FER -0.015 0.036 0.15 6 -0.13 7 13
RELA 0.032 0.004 -10000 0 -10000 0 0
ITK 0.001 0.025 -10000 0 -0.23 5 5
SOS1 0 0 -10000 0 -10000 0 0
PLCG1 0.015 0.074 0.26 21 -0.19 1 22
cytokine secretion 0.001 0.032 0.074 22 -0.073 1 23
SPHK1 -0.016 0.035 0.14 5 -0.13 8 13
PTK2 0.012 0.079 0.34 1 -0.62 5 6
NTAL/PLCgamma1/GRB2/SLP76/GADs 0.02 0.08 0.21 26 -0.16 5 31
EDG1 0 0 -10000 0 -10000 0 0
mol:DAG 0.02 0.091 0.26 29 -0.24 2 31
MAP2K2 0.02 0.07 -10000 0 -0.84 2 2
MAP2K1 0.015 0.059 -10000 0 -0.84 2 2
MAP2K7 0.031 0.006 -10000 0 -10000 0 0
KLRG1/SHP2 -0.001 0.045 0.2 11 -0.1 2 13
MAP2K4 0.001 0.18 -10000 0 -0.77 25 25
Fc epsilon R1/FcgammaRIIB 0.007 0.071 -10000 0 -0.068 122 122
mol:Choline -0.03 0.06 0.32 11 -10000 0 11
SHC/Grb2/SOS1 0.008 0.058 0.18 3 -0.13 5 8
FYN 0.029 0.011 -10000 0 -0.063 1 1
DOK1 0.032 0.002 -10000 0 -10000 0 0
PXN 0.007 0.078 0.4 3 -0.57 5 8
HCLS1 -0.018 0.039 0.14 7 -0.13 9 16
PRKCB 0.021 0.084 0.23 32 -0.18 1 33
FCGR2B 0.01 0.04 -10000 0 -0.063 120 120
IGHE -0.001 0.004 0.053 1 -10000 0 1
KLRG1/SHIP -0.014 0.027 0.077 2 -0.11 4 6
LCP2 0.027 0.023 -10000 0 -0.063 29 29
PLA2G4A -0.02 0.038 0.15 6 -0.13 9 15
RASA1 0.032 0.006 -10000 0 -10000 0 0
mol:Phosphatidic acid -0.03 0.06 0.32 11 -10000 0 11
IKK complex 0.007 0.068 0.22 23 -10000 0 23
WIPF1 0.03 0.014 -10000 0 -0.063 11 11
Regulation of nuclear SMAD2/3 signaling

Figure S41.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S41.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EP300 0.022 0.019 -10000 0 -0.026 53 53
HSPA8 0.032 0.005 -10000 0 -10000 0 0
SMAD3/SMAD4/ER alpha 0.038 0.061 -10000 0 -0.081 10 10
AKT1 0.031 0.009 -10000 0 -10000 0 0
GSC 0.007 0.026 0.089 26 -10000 0 26
NKX2-5 0.036 0.012 0.089 9 -10000 0 9
muscle cell differentiation -0.013 0.07 0.25 19 -10000 0 19
SMAD2-3/SMAD4/SP1 0.018 0.076 0.2 1 -0.11 13 14
SMAD4 -0.008 0.05 0.11 2 -0.081 98 100
CBFB 0.031 0.009 -10000 0 -0.063 4 4
SAP18 0.031 0.008 -10000 0 -10000 0 0
Cbp/p300/MSG1 0.05 0.031 -10000 0 -0.049 34 34
SMAD3/SMAD4/VDR 0.042 0.075 -10000 0 -10000 0 0
MYC 0.008 0.04 -10000 0 -0.064 119 119
CDKN2B -0.21 0.19 0.24 1 -0.36 301 302
AP1 -0.003 0.048 0.15 5 -0.085 13 18
SMAD2/SMAD2/SMAD4/SnoN/SIN3/HDAC complex/NCoR1 -0.002 0.07 -10000 0 -0.21 33 33
SMAD2-3/SMAD4/FOXO1-3a-4/FOXG1 -0.012 0.061 0.13 4 -0.23 28 32
SP3 0.018 0.034 -10000 0 -0.061 81 81
CREB1 0.033 0.001 -10000 0 -10000 0 0
FOXH1 0.035 0.011 0.11 4 -10000 0 4
SMAD3/SMAD4/GR 0.033 0.059 -10000 0 -0.08 20 20
GATA3 0.025 0.015 -10000 0 -0.063 2 2
SKI/SIN3/HDAC complex/NCoR1 -0.003 0.068 -10000 0 -0.18 43 43
MEF2C/TIF2 -0.034 0.039 0.22 8 -10000 0 8
endothelial cell migration 0.034 0.067 0.45 2 -10000 0 2
MAX 0.034 0.01 -10000 0 -10000 0 0
RBBP7 0.033 0.002 -10000 0 -10000 0 0
RBBP4 0.015 0.036 -10000 0 -0.063 89 89
RUNX2 0.032 0.004 -10000 0 -10000 0 0
RUNX3 0.031 0.009 -10000 0 -0.063 3 3
RUNX1 0.032 0.005 -10000 0 -10000 0 0
CTBP1 0.032 0.006 -10000 0 -10000 0 0
NR3C1 0.035 0.006 -10000 0 -10000 0 0
VDR 0.031 0.006 -10000 0 -10000 0 0
CDKN1A -0.015 0.053 0.33 3 -10000 0 3
KAT2B -0.001 0.002 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1 0.029 0.05 0.26 1 -0.06 23 24
DCP1A 0.032 0.006 -10000 0 -10000 0 0
SKI 0.031 0.007 -10000 0 -10000 0 0
SERPINE1 -0.032 0.067 -10000 0 -0.46 2 2
SMAD3/SMAD4/ATF2 0.024 0.06 -10000 0 -0.077 35 35
SMAD3/SMAD4/ATF3 0.008 0.064 -10000 0 -0.08 71 71
SAP30 0.032 0.006 -10000 0 -10000 0 0
Cbp/p300/PIAS3 0.052 0.023 -10000 0 -0.042 12 12
JUN -0.026 0.037 0.14 8 -10000 0 8
SMAD3/SMAD4/IRF7 0.024 0.063 -10000 0 -0.086 23 23
TFE3 -0.006 0.037 -10000 0 -0.044 171 171
COL1A2 -0.025 0.052 -10000 0 -0.21 2 2
mesenchymal cell differentiation -0.023 0.06 0.077 32 -10000 0 32
DLX1 0 0 -10000 0 -10000 0 0
TCF3 0.031 0.006 -10000 0 -10000 0 0
FOS 0.004 0.044 -10000 0 -0.061 151 151
SMAD3/SMAD4/Max 0.031 0.061 -10000 0 -0.082 19 19
Cbp/p300/SNIP1 0.057 0.022 -10000 0 -0.039 10 10
ZBTB17 0.031 0.005 -10000 0 -10000 0 0
LAMC1 -0.05 0.042 0.14 4 -0.12 14 18
TGIF2/HDAC complex/SMAD3/SMAD4 0.024 0.058 -10000 0 -0.081 23 23
IRF7 0.029 0.016 -10000 0 -0.064 12 12
ESR1 0.037 0.014 0.13 3 -10000 0 3
HNF4A 0.03 0.008 -10000 0 -10000 0 0
MEF2C -0.03 0.04 0.2 11 -10000 0 11
SMAD2-3/SMAD4 0.026 0.061 0.18 1 -0.083 16 17
Cbp/p300/Src-1 0.053 0.024 -10000 0 -0.043 4 4
IGHV3OR16-13 0.006 0.008 -10000 0 -10000 0 0
TGIF2/HDAC complex 0.03 0.012 -10000 0 -0.063 4 4
CREBBP 0.03 0.006 -10000 0 -0.026 2 2
SKIL 0.032 0.005 -10000 0 -10000 0 0
HDAC1 0.021 0.031 -10000 0 -0.063 61 61
HDAC2 0.03 0.012 -10000 0 -0.063 4 4
SNIP1 0.032 0.005 -10000 0 -10000 0 0
GCN5L2 -0.002 0.002 -10000 0 -10000 0 0
SMAD3/SMAD4/TFE3 0 0.072 -10000 0 -0.09 84 84
MSG1/HSC70 0.044 0.022 -10000 0 -0.049 24 24
SMAD2 0.036 0.012 0.13 3 -10000 0 3
SMAD3 0.001 0.039 -10000 0 -0.065 8 8
SMAD3/E2F4-5/DP1/p107/SMAD4 -0.001 0.042 -10000 0 -0.14 29 29
SMAD2/SMAD2/SMAD4 -0.01 0.039 0.12 9 -0.18 11 20
NCOR1 0.032 0.004 -10000 0 -10000 0 0
NCOA2 0.032 0.004 -10000 0 -10000 0 0
NCOA1 0.031 0.007 -10000 0 -10000 0 0
MYOD/E2A 0.046 0.011 -10000 0 -10000 0 0
SMAD2-3/SMAD4/SP1/MIZ-1 0.035 0.081 0.21 1 -0.11 4 5
IFNB1 -0.022 0.033 0.14 8 -10000 0 8
SMAD3/SMAD4/MEF2C -0.009 0.054 0.2 3 -10000 0 3
CITED1 0.028 0.02 -10000 0 -0.063 24 24
SMAD2-3/SMAD4/ARC105 0.041 0.066 0.19 1 -0.086 8 9
RBL1 0 0 -10000 0 -10000 0 0
SMAD2-3/SMAD4/FOXO1-3a-4/CEBPB 0.001 0.051 0.16 2 -0.22 17 19
RUNX1-3/PEBPB2 0.059 0.025 -10000 0 -0.049 8 8
SMAD7 -0.024 0.064 0.12 1 -0.18 37 38
MYC/MIZ-1 0.022 0.041 -10000 0 -0.051 116 116
SMAD3/SMAD4 -0.045 0.066 -10000 0 -0.24 31 31
IL10 -0.032 0.04 0.16 13 -10000 0 13
PIASy/HDAC complex 0.033 0.006 -10000 0 -10000 0 0
PIAS3 0.031 0.004 -10000 0 -10000 0 0
CDK2 0.025 0.021 -10000 0 -0.064 24 24
IL5 -0.033 0.04 0.16 13 -10000 0 13
CDK4 -0.021 0.044 -10000 0 -0.064 251 251
PIAS4 0.033 0.006 -10000 0 -10000 0 0
ATF3 0.012 0.038 -10000 0 -0.063 103 103
SMAD3/SMAD4/SP1 -0.003 0.069 -10000 0 -0.11 28 28
FOXG1 0.027 0.012 -10000 0 -10000 0 0
FOXO3 -0.019 0.007 -10000 0 -10000 0 0
FOXO1 -0.019 0.008 -10000 0 -10000 0 0
FOXO4 -0.02 0.006 -10000 0 -10000 0 0
heart looping -0.03 0.04 0.2 11 -10000 0 11
CEBPB 0.029 0.016 -10000 0 -0.062 11 11
SMAD3/SMAD4/DLX1 0.007 0.047 -10000 0 -0.068 32 32
MYOD1 0.032 0.005 -10000 0 -10000 0 0
SMAD3/SMAD4/HNF4 0.024 0.058 -10000 0 -0.075 37 37
SMAD3/SMAD4/GATA3 0.017 0.065 -10000 0 -0.086 29 29
SnoN/SIN3/HDAC complex/NCoR1 0.032 0.005 -10000 0 -10000 0 0
SMAD3/SMAD4/RUNX1-3/PEBPB2 0.052 0.07 -10000 0 -0.087 3 3
SMAD3/SMAD4/SP1-3 0.01 0.081 -10000 0 -0.12 28 28
MED15 0.031 0.007 -10000 0 -10000 0 0
SP1 -0.004 0.036 -10000 0 -0.053 45 45
SIN3B 0.031 0.007 -10000 0 -10000 0 0
SIN3A 0 0 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1/NKX2-5 0.04 0.06 -10000 0 -10000 0 0
ITGB5 -0.043 0.052 0.24 9 -10000 0 9
TGIF/SIN3/HDAC complex/CtBP -0.019 0.06 -10000 0 -0.17 48 48
SMAD3/SMAD4/AR 0.023 0.061 -10000 0 -0.078 37 37
AR 0.031 0.012 -10000 0 -0.063 8 8
negative regulation of cell growth -0.003 0.048 -10000 0 -0.22 14 14
SMAD3/SMAD4/MYOD 0.023 0.06 -10000 0 -0.076 38 38
E2F5 0.032 0.004 -10000 0 -10000 0 0
E2F4 0.032 0.004 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1/SMIF 0.043 0.066 0.27 1 -10000 0 1
SMAD2-3/SMAD4/FOXO1-3a-4 -0.001 0.042 0.13 3 -0.2 12 15
TFDP1 0.029 0.015 -10000 0 -0.063 11 11
SMAD3/SMAD4/AP1 0.012 0.064 -10000 0 -0.085 14 14
SMAD3/SMAD4/RUNX2 0.024 0.06 -10000 0 -0.078 31 31
TGIF2 0.03 0.012 -10000 0 -0.063 4 4
TGIF1 -0.033 0.043 -10000 0 -0.063 343 343
ATF2 0.032 0.002 -10000 0 -10000 0 0
Integrins in angiogenesis

Figure S42.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S42.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR2 homodimer/VEGFA homodimer -0.006 0.047 -10000 0 -0.051 258 258
alphaV beta3 Integrin 0.06 0.025 -10000 0 -0.048 17 17
PTK2 -0.01 0.063 0.29 7 -0.26 6 13
IGF1R 0.032 0.004 -10000 0 -10000 0 0
PI4KB 0.032 0.005 -10000 0 -10000 0 0
MFGE8 0.032 0.007 -10000 0 -0.063 2 2
SRC 0.031 0.008 -10000 0 -10000 0 0
CDKN1B 0.013 0.051 -10000 0 -0.26 17 17
VEGFA -0.019 0.047 -10000 0 -0.063 274 274
ILK 0.014 0.048 -10000 0 -0.26 15 15
ROCK1 0.032 0.005 -10000 0 -10000 0 0
AKT1 0.001 0.041 -10000 0 -0.25 13 13
PTK2B -0.029 0.058 0.16 40 -10000 0 40
alphaV/beta3 Integrin/JAM-A 0.055 0.041 0.17 6 -10000 0 6
CBL 0.032 0.004 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
alphaV beta3 Integrin/ANGPTL3 0.06 0.024 -10000 0 -0.048 15 15
IGF-1R heterotetramer/IGF1/IRS1/Shp2 0.079 0.023 -10000 0 -10000 0 0
VEGF/Rho/ROCK/alphaV/beta3 Integrin -0.009 0.044 -10000 0 -0.16 24 24
alphaV/beta3 Integrin/Syndecan-1 0.051 0.038 -10000 0 -0.05 55 55
PI4KA 0.012 0.016 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1 0.043 0.06 -10000 0 -0.094 2 2
PI4 Kinase 0.017 0.023 -10000 0 -10000 0 0
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
alphaV/beta3 Integrin/Osteopontin 0.022 0.055 -10000 0 -0.05 178 178
RPS6KB1 -0.048 0.043 0.68 1 -10000 0 1
TLN1 0.021 0.027 -10000 0 -0.063 43 43
MAPK3 0 0.039 -10000 0 -0.28 8 8
GPR124 0.032 0.007 -10000 0 -0.063 2 2
MAPK1 -0.001 0.039 -10000 0 -0.28 8 8
PXN 0.032 0.003 -10000 0 -10000 0 0
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
alphaV/beta3 Integrin/Tumstatin 0.061 0.022 -10000 0 -0.048 15 15
cell adhesion 0.047 0.03 -10000 0 -0.082 4 4
ANGPTL3 0.032 0.005 -10000 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/Src 0.003 0.054 -10000 0 -0.049 237 237
IGF-1R heterotetramer 0.032 0.004 -10000 0 -10000 0 0
Rac1/GDP 0.017 0.011 -10000 0 -10000 0 0
TGFBR2 0.031 0.01 -10000 0 -0.063 5 5
ITGB3 0.032 0.003 -10000 0 -10000 0 0
IGF1 0.032 0.009 -10000 0 -0.063 4 4
RAC1 0.023 0.015 -10000 0 -10000 0 0
regulation of cell-matrix adhesion 0.059 0.024 -10000 0 -0.048 18 18
apoptosis 0.029 0.016 -10000 0 -0.063 15 15
CD47 0.031 0.008 -10000 0 -0.063 2 2
alphaV/beta3 Integrin/CD47 0.059 0.026 -10000 0 -0.044 26 26
VCL 0.025 0.014 -10000 0 -10000 0 0
alphaV/beta3 Integrin/Del1 0.06 0.024 -10000 0 -0.043 24 24
CSF1 0.032 0.004 -10000 0 -10000 0 0
PIK3C2A 0.009 0.013 -10000 0 -0.25 1 1
PI4 Kinase/Pyk2 -0.02 0.034 0.098 8 -10000 0 8
VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin 0.005 0.064 -10000 0 -0.069 20 20
FAK1/Vinculin -0.005 0.056 0.28 6 -0.23 6 12
alphaV beta3/Integrin/ppsTEM5 0.06 0.024 -10000 0 -0.048 18 18
RHOA 0.032 0.006 -10000 0 -10000 0 0
VTN 0.032 0.007 -10000 0 -0.063 2 2
BCAR1 0 0 -10000 0 -10000 0 0
FGF2 0.032 0.007 -10000 0 -0.063 2 2
F11R -0.024 0.008 -10000 0 -10000 0 0
alphaV/beta3 Integrin/Lactadherin 0.06 0.025 -10000 0 -0.048 17 17
alphaV/beta3 Integrin/TGFBR2 0.059 0.027 -10000 0 -0.048 20 20
alphaV/beta3 Integrin/c-FMS/Cbl/Cas 0.057 0.023 -10000 0 -0.042 16 16
HSP90AA1 0.03 0.008 -10000 0 -10000 0 0
alphaV/beta3 Integrin/Talin 0.043 0.039 -10000 0 -0.044 55 55
mol:GDP 0 0 -10000 0 -10000 0 0
FN1 0.014 0.037 -10000 0 -0.063 96 96
alphaV/beta3 Integrin/Pyk2 0.002 0.067 0.17 34 -0.072 18 52
SDC1 0.024 0.027 -10000 0 -0.063 45 45
VAV3 -0.028 0.021 0.18 5 -10000 0 5
PTPN11 0.032 0.003 -10000 0 -10000 0 0
IRS1 0.032 0.009 -10000 0 -0.063 4 4
FAK1/Paxillin -0.003 0.062 0.26 7 -0.22 6 13
cell migration -0.016 0.051 0.25 7 -0.21 6 13
ITGAV 0.03 0.016 -10000 0 -0.063 15 15
PI3K 0.061 0.049 0.16 5 -10000 0 5
SPP1 -0.001 0.045 -10000 0 -0.063 175 175
KDR 0.028 0.017 -10000 0 -0.063 14 14
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
alphaV/beta3 Integrin/Caspase 8 0.029 0.016 -10000 0 -0.063 15 15
COL4A3 0.033 0.001 -10000 0 -10000 0 0
angiogenesis 0.002 0.044 0.18 3 -0.31 8 11
Rac1/GTP -0.023 0.024 0.18 4 -10000 0 4
EDIL3 0.032 0.004 -10000 0 -10000 0 0
cell proliferation 0.058 0.027 -10000 0 -0.048 20 20
Canonical Wnt signaling pathway

Figure S43.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S43.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.023 0.031 -10000 0 -0.057 61 61
AES 0.034 0.009 -10000 0 -10000 0 0
FBXW11 0.032 0.005 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
LRP6/FZD1 0.032 0.024 -10000 0 -0.05 4 4
SMAD4 0.01 0.04 -10000 0 -0.063 117 117
DKK2 0.031 0.012 -10000 0 -0.031 16 16
TLE1 0.034 0.008 -10000 0 -10000 0 0
MACF1 0.032 0.006 -10000 0 -10000 0 0
CTNNB1 0.096 0.099 0.22 148 -0.29 5 153
WIF1 0.004 0.01 -10000 0 -10000 0 0
beta catenin/RanBP3 0.098 0.078 0.23 53 -0.3 3 56
KREMEN2 0.032 0.003 -10000 0 -10000 0 0
DKK1 0.006 0.037 -10000 0 -0.062 101 101
beta catenin/beta TrCP1 0.11 0.095 0.22 145 -0.26 6 151
FZD1 0.022 0.017 -10000 0 -0.063 4 4
AXIN2 -0.014 0.022 -10000 0 -0.1 5 5
AXIN1 0.034 0.004 -10000 0 -10000 0 0
RAN 0.032 0.004 -10000 0 -10000 0 0
Axin1/APC/GSK3/beta catenin 0.045 0.085 -10000 0 -0.45 9 9
beta catenin/TCF/CtBP/CBP/TLE1/AES/SMAD4 0.064 0.07 0.22 22 -0.22 9 31
Axin1/APC/GSK3 0.041 0.063 0.16 74 -0.23 5 79
Axin1/APC/GSK3/beta catenin/Macf1 0.065 0.092 0.2 123 -0.24 8 131
HNF1A 0.035 0.007 -10000 0 -10000 0 0
CTBP1 0.034 0.008 -10000 0 -10000 0 0
MYC -0.025 0.098 0.45 15 -10000 0 15
RANBP3 0.032 0.006 -10000 0 -10000 0 0
DKK2/LRP6/Kremen 2 0.06 0.023 -10000 0 -0.043 14 14
NKD1 -0.001 0.001 -10000 0 -10000 0 0
TCF4 0.034 0.009 -10000 0 -10000 0 0
TCF3 0.034 0.009 -10000 0 -10000 0 0
WNT1/LRP6/FZD1/Axin1 0.053 0.042 -10000 0 -0.06 1 1
Ran/GTP 0.024 0.003 -10000 0 -10000 0 0
CtBP/CBP/TCF/TLE1/AES 0.035 0.05 0.19 7 -0.19 3 10
LEF1 0.034 0.01 -10000 0 -0.059 3 3
DVL1 0.023 0.023 -10000 0 -0.14 1 1
CSNK2A1 0.031 0.008 -10000 0 -10000 0 0
beta catenin/TCF/CtBP/CBP/TLE1/AES 0.067 0.062 0.24 19 -0.22 2 21
DKK1/LRP6/Kremen 2 0.025 0.047 -10000 0 -0.047 107 107
LRP6 0.032 0.007 -10000 0 -10000 0 0
CSNK1A1 0.037 0.008 -10000 0 -10000 0 0
NLK 0.032 0.004 -10000 0 -10000 0 0
CCND1 -0.034 0.058 0.41 3 -10000 0 3
WNT1 0.032 0.006 -10000 0 -10000 0 0
GSK3A 0.032 0.007 -10000 0 -10000 0 0
GSK3B 0.032 0.006 -10000 0 -10000 0 0
FRAT1 0.024 0.014 -10000 0 -10000 0 0
PPP2R5D 0.032 0.037 -10000 0 -0.24 5 5
APC 0.032 0.11 0.18 150 -10000 0 150
WNT1/LRP6/FZD1 0 0.025 -10000 0 -0.24 4 4
CREBBP 0.035 0.007 -10000 0 -10000 0 0
IL1-mediated signaling events

Figure S44.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S44.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
UBC13/UEV1A 0.024 0.003 -10000 0 -10000 0 0
PRKCZ 0 0 -10000 0 -10000 0 0
MAP3K7IP2 0 0 -10000 0 -10000 0 0
ERC1 0.031 0.006 -10000 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 -0.002 0.053 -10000 0 -0.18 29 29
IRAK/TOLLIP 0.03 0.009 -10000 0 -0.031 4 4
IKBKB 0.032 0.003 -10000 0 -10000 0 0
IKBKG 0.032 0.003 -10000 0 -10000 0 0
IL1 alpha/IL1R2 0.04 0.027 -10000 0 -0.05 40 40
IL1A 0.032 0.008 -10000 0 -0.063 3 3
IL1B -0.032 0.014 0 11 -0.051 171 182
IRAK/TRAF6/p62/Atypical PKCs 0.056 0.026 0.17 4 -10000 0 4
IL1R2 0.025 0.025 -10000 0 -0.063 37 37
IL1R1 0.032 0.008 -10000 0 -0.063 3 3
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP -0.011 0.047 -10000 0 -0.17 22 22
TOLLIP 0.031 0.006 -10000 0 -10000 0 0
TICAM2 0 0 -10000 0 -10000 0 0
MAP3K3 0.032 0.003 -10000 0 -10000 0 0
TAK1/TAB1/TAB2 0.021 0.005 -10000 0 -0.031 1 1
IKK complex/ELKS -0.026 0.096 -10000 0 -0.19 120 120
JUN -0.025 0.022 0.14 4 -10000 0 4
MAP3K7 0.031 0.008 -10000 0 -0.063 1 1
IL1 beta fragment/IL1R1/IL1RAP/PI3K 0.019 0.068 0.18 2 -0.091 6 8
IL1 alpha/IL1R1/IL1RAP/MYD88 0.051 0.057 -10000 0 -0.069 11 11
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 0.056 0.066 -10000 0 -10000 0 0
IL1 beta fragment/IL1R1/IL1RAP 0.009 0.05 -10000 0 -0.054 186 186
NFKB1 0.031 0.009 -10000 0 -0.063 4 4
MAPK8 -0.022 0.023 0.16 5 -10000 0 5
IRAK1 -0.017 0.003 -10000 0 -10000 0 0
IL1RN/IL1R1 0.048 0.008 -10000 0 -0.05 3 3
IRAK4 0.031 0.008 -10000 0 -0.063 1 1
PRKCI 0.032 0.006 -10000 0 -0.063 1 1
TRAF6 0.032 0.005 -10000 0 -10000 0 0
PI3K 0.039 0.023 -10000 0 -0.05 16 16
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP -0.004 0.047 0.13 1 -0.18 22 23
CHUK 0.024 0.015 -10000 0 -0.063 1 1
IL1 beta fragment/IL1R1/IL1RAP/MYD88s 0.009 0.05 -10000 0 -0.054 186 186
IL1 beta/IL1R2 0.004 0.044 -10000 0 -0.072 21 21
IRAK/TRAF6/TAK1/TAB1/TAB2 0.038 0.023 0.16 4 -10000 0 4
NF kappa B1 p50/RelA 0.007 0.064 -10000 0 -0.098 7 7
IRAK3 0.031 0.008 -10000 0 -0.063 1 1
IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 0.015 0.057 0.16 2 -0.07 33 35
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP 0.007 0.041 -10000 0 -0.12 37 37
IL1 alpha/IL1R1/IL1RAP 0.053 0.036 -10000 0 -0.049 46 46
RELA 0.032 0.004 -10000 0 -10000 0 0
MAP3K7IP1 0 0 -10000 0 -10000 0 0
SQSTM1 0.032 0.006 -10000 0 -0.063 1 1
MYD88 0.019 0.032 -10000 0 -0.063 67 67
IRAK/TRAF6/MEKK3 0.05 0.018 0.18 4 -10000 0 4
IL1RAP 0.024 0.026 -10000 0 -0.063 41 41
UBE2N 0.032 0.004 -10000 0 -10000 0 0
IRAK/TRAF6 -0.052 0.016 0.035 1 -0.092 4 5
CASP1 0.001 0.044 -10000 0 -0.063 166 166
IL1RN/IL1R2 0.041 0.026 -10000 0 -0.05 37 37
IL1 beta fragment/IL1R1/IL1RAP/MYD88 0.011 0.064 0.17 2 -0.075 67 69
TMEM189-UBE2V1 0 0 -10000 0 -10000 0 0
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP 0.007 0.048 -10000 0 -0.23 12 12
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
IL1RN 0.032 0.002 -10000 0 -10000 0 0
TRAF6/TAK1/TAB1/TAB2 0.042 0.02 -10000 0 -0.035 5 5
MAP2K6 -0.023 0.025 0.17 8 -10000 0 8
Signaling events regulated by Ret tyrosine kinase

Figure S45.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S45.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 0.013 0.052 -10000 0 -0.35 10 10
Crk/p130 Cas/Paxillin -0.037 0.081 -10000 0 -0.18 117 117
JUN -0.012 0.029 -10000 0 -0.18 7 7
HRAS 0.031 0.007 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/GRB10 0.043 0.05 -10000 0 -0.056 3 3
RAP1A 0.032 0.004 -10000 0 0 9 9
FRS2 0.031 0.007 -10000 0 -10000 0 0
RAP1A/GDP 0.024 0.003 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/DOK1 0.048 0.058 -10000 0 -0.058 1 1
EntrezGene:5979 0 0 -10000 0 -10000 0 0
PTPN11 0.032 0.003 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.032 0.005 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/Enigma 0.036 0.042 -10000 0 -0.041 9 9
RHOA 0.032 0.006 -10000 0 -10000 0 0
RAP1A/GTP 0.044 0.056 -10000 0 -10000 0 0
GRB7 0.032 0.005 -10000 0 -0.063 1 1
RET51/GFRalpha1/GDNF 0.048 0.057 -10000 0 -0.058 1 1
MAPKKK cascade -0.005 0.076 -10000 0 -0.13 126 126
BCAR1 0 0 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/IRS1 0.036 0.042 -10000 0 -0.043 8 8
lamellipodium assembly -0.013 0.061 -10000 0 -0.17 49 49
RET51/GFRalpha1/GDNF/SHC 0.038 0.061 -10000 0 -0.062 6 6
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
RET9/GFRalpha1/GDNF/SHC 0.029 0.046 -10000 0 -0.043 43 43
RET9/GFRalpha1/GDNF/Shank3 0.024 0.029 -10000 0 -0.024 137 137
MAPK3 -0.038 0.03 0.17 9 -10000 0 9
DOK1 0.032 0.002 -10000 0 -10000 0 0
DOK6 0 0 -10000 0 -10000 0 0
PXN 0.032 0.003 -10000 0 -10000 0 0
neurite development -0.027 0.029 0.18 7 -10000 0 7
DOK5 0.028 0.011 -10000 0 -10000 0 0
GFRA1 0.024 0.015 -10000 0 -0.063 1 1
MAPK8 0.001 0.03 -10000 0 -0.12 25 25
HRAS/GTP 0.019 0.097 -10000 0 -0.14 131 131
tube development 0.02 0.035 0.16 10 -10000 0 10
MAPK1 -0.033 0.046 0.23 10 -10000 0 10
RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.009 0.055 -10000 0 -0.11 122 122
Rac1/GDP 0.017 0.011 -10000 0 -10000 0 0
SRC 0.031 0.008 -10000 0 -10000 0 0
PDLIM7 0.032 0.004 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/Dok6 0.046 0.05 -10000 0 -10000 0 0
SHC1 0.024 0.026 -10000 0 -0.063 40 40
RET51/GFRalpha1/GDNF/Dok4 0.047 0.058 -10000 0 -0.058 1 1
RET51/GFRalpha1/GDNF/Dok5 0.047 0.053 -10000 0 -10000 0 0
PRKCA 0.032 0.004 -10000 0 -10000 0 0
HRAS/GDP 0.023 0.005 -10000 0 -10000 0 0
CREB1 -0.036 0.096 -10000 0 -0.2 125 125
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.013 0.055 -10000 0 -0.11 124 124
RET51/GFRalpha1/GDNF/Grb7 0.048 0.058 -10000 0 -0.057 5 5
mol:GDP 0 0 -10000 0 -10000 0 0
RET 0.025 0.014 -10000 0 -0.063 1 1
DOK4 0.032 0.005 -10000 0 -10000 0 0
JNK cascade -0.012 0.029 -10000 0 -0.18 7 7
RET9/GFRalpha1/GDNF/FRS2 0.036 0.041 -10000 0 -0.039 5 5
SHANK3 0 0 -10000 0 -10000 0 0
RASA1 0.032 0.006 -10000 0 -10000 0 0
NCK1 0.03 0.015 -10000 0 -0.063 11 11
RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.016 0.053 -10000 0 -0.1 125 125
RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.027 0.095 -10000 0 -0.19 125 125
RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK -0.032 0.098 -10000 0 -0.19 136 136
RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 0.007 0.033 -10000 0 -0.12 26 26
PI3K -0.043 0.11 -10000 0 -0.23 120 120
SOS1 0 0 -10000 0 -10000 0 0
RET9/GFRalpha1/GDNF/Shank3/Grb2 0.033 0.039 -10000 0 -0.037 4 4
GRB10 0.021 0.018 -10000 0 -0.063 6 6
activation of MAPKK activity -0.014 0.069 0.1 7 -0.15 102 109
RET51/GFRalpha1/GDNF/FRS2 0.047 0.057 -10000 0 -0.058 1 1
GAB1 0.032 0.008 -10000 0 -0.063 3 3
IRS1 0.032 0.009 -10000 0 -0.063 4 4
IRS2 0.03 0.008 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 0.009 0.036 -10000 0 -0.12 28 28
RET51/GFRalpha1/GDNF/PKC alpha 0.048 0.058 -10000 0 -0.058 1 1
GRB2 0.032 0.006 -10000 0 -10000 0 0
PRKACA 0.032 0.006 -10000 0 0 17 17
GDNF 0.032 0.004 -10000 0 -10000 0 0
RAC1 0.023 0.015 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/IRS1 0.047 0.058 -10000 0 -0.063 3 3
Rac1/GTP -0.013 0.071 -10000 0 -0.2 49 49
RET9/GFRalpha1/GDNF 0.032 0.02 -10000 0 -0.04 1 1
GFRalpha1/GDNF 0.035 0.022 -10000 0 -0.05 1 1
E-cadherin signaling in keratinocytes

Figure S46.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S46.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
keratinocyte differentiation 0.004 0.038 0.15 15 -0.19 7 22
adherens junction organization 0.007 0.041 0.13 7 -0.15 19 26
mol:GTP 0 0 -10000 0 -10000 0 0
Rac1/GDP 0.046 0.071 0.16 130 -0.15 5 135
FMN1 0.013 0.038 0.13 7 -0.14 16 23
mol:IP3 0.004 0.024 0.085 1 -0.12 9 10
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin 0.018 0.04 0.14 7 -0.15 16 23
CTNNB1 0.032 0.006 -10000 0 -10000 0 0
AKT1 0.012 0.035 0.1 29 -0.16 6 35
E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin 0.024 0.06 -10000 0 -0.25 15 15
CTNND1 0.031 0.014 -10000 0 -0.064 10 10
mol:PI-4-5-P2 0.007 0.037 0.13 7 -0.15 16 23
VASP 0.007 0.034 0.13 7 -0.14 14 21
ZYX 0.001 0.03 0.13 2 -0.17 9 11
JUB 0.013 0.038 0.13 7 -0.14 16 23
EGFR(dimer) 0.011 0.035 0.15 2 -0.16 9 11
E-cadherin/beta catenin-gamma catenin 0.058 0.026 -10000 0 -0.052 19 19
mol:PI-3-4-5-P3 0.041 0.049 0.16 31 -0.15 8 39
PIK3CA 0.029 0.019 -10000 0 -0.057 21 21
PI3K 0.042 0.05 0.16 31 -0.15 8 39
FYN -0.011 0.054 0.15 11 -0.2 26 37
mol:Ca2+ 0.004 0.025 0.085 1 -0.13 10 11
JUP 0.03 0.017 -10000 0 -0.062 16 16
PIK3R1 0.031 0.01 -10000 0 -10000 0 0
mol:DAG 0.004 0.024 0.085 1 -0.12 9 10
CDH1 0.031 0.013 -10000 0 -0.061 8 8
RhoA/GDP 0.075 0.077 0.16 223 -0.14 6 229
establishment of polarity of embryonic epithelium 0.006 0.035 0.13 7 -0.14 16 23
SRC 0.031 0.008 -10000 0 -10000 0 0
RAC1 0.023 0.015 -10000 0 -10000 0 0
RHOA 0.032 0.006 -10000 0 -10000 0 0
EGFR 0.012 0.018 -10000 0 -0.063 6 6
CASR -0.012 0.033 0.15 12 -0.14 6 18
RhoA/GTP 0.02 0.037 0.14 12 -0.12 10 22
AKT2 0.01 0.034 0.1 22 -0.14 9 31
actin cable formation 0.004 0.034 0.12 7 -0.14 16 23
apoptosis -0.01 0.043 0.17 9 -0.17 12 21
CTNNA1 0.033 0.005 -10000 0 -10000 0 0
mol:GDP -0.008 0.021 0.14 1 -0.14 6 7
PIP5K1A 0.007 0.038 0.13 7 -0.15 16 23
PLCG1 0.004 0.025 0.086 1 -0.13 9 10
Rac1/GTP 0.015 0.039 0.15 1 -0.16 9 10
homophilic cell adhesion 0 0.003 -10000 0 -10000 0 0
BMP receptor signaling

Figure S47.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S47.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BMP7/BMPR2/BMPR1A-1B/FS 0.054 0.063 -10000 0 -10000 0 0
SMAD6-7/SMURF1 0.043 0.033 -10000 0 -0.037 11 11
NOG 0 0 -10000 0 -10000 0 0
SMAD9 -0.03 0.16 -10000 0 -0.49 53 53
SMAD4 0.01 0.04 -10000 0 -0.063 117 117
SMAD5 -0.028 0.093 0.12 2 -0.31 39 41
BMP7/USAG1 0.031 0.024 -10000 0 -0.05 6 6
SMAD5/SKI -0.016 0.097 -10000 0 -0.3 40 40
SMAD1 -0.01 0.072 -10000 0 -0.25 26 26
BMP2 0.022 0.027 -10000 0 -0.063 44 44
SMAD1/SMAD1/SMAD4 0 0.071 -10000 0 -0.25 19 19
BMPR1A 0.023 0.017 -10000 0 -0.063 6 6
BMPR1B 0.032 0.006 -10000 0 -0.063 1 1
BMPR1A-1B/BAMBI 0.029 0.052 -10000 0 -0.046 134 134
AHSG 0.031 0.008 -10000 0 -0.063 2 2
CER1 0.029 0.011 -10000 0 -10000 0 0
BMP2-4/CER1 0.039 0.045 -10000 0 -0.043 103 103
BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA -0.003 0.061 -10000 0 -0.19 40 40
BMP2-4 (homodimer) 0.033 0.031 -10000 0 -0.05 47 47
RGMB 0 0 -10000 0 -10000 0 0
BMP6/BMPR2/BMPR1A-1B 0.048 0.056 -10000 0 -10000 0 0
RGMA 0 0 -10000 0 -10000 0 0
SMURF1 0.023 0.015 -10000 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP -0.016 0.058 0.069 1 -0.12 102 103
BMP2-4/USAG1 0.032 0.041 -10000 0 -0.05 49 49
SMAD6/SMURF1/SMAD5 -0.008 0.087 -10000 0 -0.3 34 34
SOSTDC1 0.022 0.017 -10000 0 -0.063 6 6
BMP7/BMPR2/BMPR1A-1B 0.05 0.053 -10000 0 -10000 0 0
SKI 0.031 0.007 -10000 0 -10000 0 0
BMP6 (homodimer) 0.032 0.007 -10000 0 -0.063 2 2
HFE2 0 0 -10000 0 -10000 0 0
ZFYVE16 0.031 0.01 -10000 0 -0.063 5 5
MAP3K7 0.031 0.008 -10000 0 -0.063 1 1
BMP2-4/CHRD 0.044 0.041 -10000 0 -0.045 71 71
SMAD5/SMAD5/SMAD4 -0.022 0.099 -10000 0 -0.31 40 40
MAPK1 0.03 0.009 -10000 0 -10000 0 0
TAK1/TAB family 0.01 0.053 -10000 0 -0.18 20 20
BMP7 (homodimer) 0.03 0.01 -10000 0 -0.063 1 1
NUP214 0.031 0.007 -10000 0 -10000 0 0
BMP6/FETUA 0.045 0.014 -10000 0 -0.05 4 4
SMAD1/SKI 0.003 0.081 -10000 0 -0.25 28 28
SMAD6 0.032 0.005 -10000 0 -10000 0 0
CTDSP2 0.028 0.011 -10000 0 -10000 0 0
BMP2-4/FETUA 0.044 0.041 -10000 0 -0.045 74 74
MAP3K7IP1 0 0 -10000 0 -10000 0 0
GREM1 0.027 0.02 -10000 0 -0.063 22 22
BMPR2 (homodimer) 0.032 0.001 -10000 0 -10000 0 0
GADD34/PP1CA 0.057 0.028 -10000 0 -0.049 7 7
BMPR1A-1B (homodimer) 0.034 0.023 -10000 0 -0.05 5 5
CHRDL1 0 0 -10000 0 -10000 0 0
ENDOFIN/SMAD1 0.002 0.084 0.29 1 -0.25 29 30
SMAD6-7/SMURF1/SMAD1 0.016 0.079 -10000 0 -0.26 18 18
SMAD6/SMURF1 0.023 0.015 -10000 0 -10000 0 0
BAMBI 0.02 0.024 -10000 0 -0.063 27 27
SMURF2 0.032 0.005 -10000 0 -0.063 1 1
BMP2-4/CHRDL1 0.03 0.027 -10000 0 -0.04 50 50
BMP2-4/GREM1 0.039 0.045 -10000 0 -0.046 100 100
SMAD7 0.031 0.007 -10000 0 -0.063 1 1
SMAD8A/SMAD8A/SMAD4 -0.027 0.16 -10000 0 -0.46 59 59
SMAD1/SMAD6 0.002 0.068 -10000 0 -0.26 19 19
TAK1/SMAD6 0.033 0.023 -10000 0 -0.05 1 1
BMP7 0.03 0.01 -10000 0 -0.063 1 1
BMP6 0.032 0.007 -10000 0 -0.063 2 2
MAP3K7IP2 0 0 -10000 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 -0.005 0.051 -10000 0 -0.13 49 49
PPM1A 0.031 0.008 -10000 0 -10000 0 0
SMAD1/SMURF2 0.003 0.083 0.29 1 -0.25 28 29
SMAD7/SMURF1 0.033 0.023 -10000 0 -0.05 1 1
CTDSPL 0.032 0.005 -10000 0 -10000 0 0
PPP1CA 0.032 0.004 -10000 0 -10000 0 0
XIAP 0 0 -10000 0 -10000 0 0
CTDSP1 0.032 0.007 -10000 0 -0.063 3 3
PPP1R15A 0.031 0.009 -10000 0 -0.063 1 1
BMP2-4/BMPR2/BMPR1A-1B/RGM/FS -0.015 0.059 -10000 0 -0.12 103 103
CHRD 0.031 0.006 -10000 0 -10000 0 0
BMPR2 0.033 0.001 -10000 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM -0.018 0.059 -10000 0 -0.12 108 108
BMP4 0.029 0.014 -10000 0 -0.063 8 8
FST 0.029 0.017 -10000 0 -0.063 16 16
BMP2-4/NOG 0.03 0.027 -10000 0 -0.04 50 50
BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 0.05 0.055 -10000 0 -10000 0 0
Signaling events mediated by PTP1B

Figure S48.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S48.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB 0.032 0.007 -10000 0 -0.063 2 2
Jak2/Leptin Receptor 0.019 0.12 -10000 0 -0.29 53 53
PTP1B/AKT1 0.039 0.059 0.17 10 -0.23 10 20
FYN 0.029 0.011 -10000 0 -0.063 1 1
p210 bcr-abl/PTP1B 0.026 0.06 0.16 15 -0.23 11 26
EGFR 0.012 0.019 -10000 0 -0.052 9 9
EGF/EGFR 0.01 0.041 -10000 0 -0.2 9 9
CSF1 0.032 0.004 -10000 0 -10000 0 0
AKT1 0.031 0.009 -10000 0 -0.026 2 2
INSR 0.031 0.008 -10000 0 -0.026 5 5
PTP1B/N-cadherin 0.038 0.061 0.16 9 -0.23 11 20
Insulin Receptor/Insulin 0.054 0.064 0.18 2 -0.2 15 17
HCK 0.014 0.036 -10000 0 -0.063 85 85
CRK 0.032 0.005 -10000 0 -10000 0 0
TYK2 0.026 0.077 0.27 25 -0.25 9 34
EGF 0.034 0.008 -10000 0 -0.053 3 3
YES1 0.017 0.034 -10000 0 -0.063 75 75
CAV1 0.05 0.085 0.17 109 -0.25 10 119
TXN 0.033 0.007 -10000 0 -10000 0 0
PTP1B/IRS1/GRB2 0.056 0.065 0.18 7 -0.23 11 18
cell migration -0.026 0.06 0.23 11 -0.16 15 26
STAT3 0.031 0.014 -10000 0 -0.062 10 10
PRLR 0.033 0.005 -10000 0 -10000 0 0
ITGA2B 0.032 0.003 -10000 0 -10000 0 0
CSF1R 0.025 0.026 -10000 0 -0.063 40 40
Prolactin Receptor/Prolactin 0.049 0.014 -10000 0 -10000 0 0
FGR 0.029 0.017 -10000 0 -0.063 15 15
PTP1B/p130 Cas 0.022 0.055 0.12 31 -0.2 13 44
Crk/p130 Cas 0.038 0.06 0.17 8 -0.22 11 19
DOK1 0.022 0.062 0.18 14 -0.26 11 25
JAK2 0.005 0.12 0.2 2 -0.3 54 56
Jak2/Leptin Receptor/Leptin 0.026 0.076 -10000 0 -0.25 16 16
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
PTPN1 0.026 0.06 0.14 31 -0.22 13 44
LYN 0.021 0.031 -10000 0 -0.063 60 60
CDH2 0.031 0.009 -10000 0 -0.063 2 2
SRC 0.033 0.059 -10000 0 -0.41 7 7
ITGB3 0.032 0.003 -10000 0 -10000 0 0
CAT1/PTP1B 0.045 0.094 0.24 44 -0.27 13 57
CAPN1 0.032 0.004 -10000 0 -10000 0 0
CSK 0.032 0.005 -10000 0 -10000 0 0
PI3K 0.053 0.07 -10000 0 -0.2 14 14
mol:H2O2 0.003 0.004 0.036 1 -10000 0 1
STAT3 (dimer) 0.025 0.07 -10000 0 -0.23 16 16
negative regulation of transcription 0.005 0.12 0.2 2 -0.3 54 56
FCGR2A -0.015 0.047 -10000 0 -0.063 253 253
FER 0.034 0.005 -10000 0 -10000 0 0
alphaIIb/beta3 Integrin 0.048 0.005 -10000 0 -10000 0 0
BLK 0.032 0.005 -10000 0 -10000 0 0
Insulin Receptor/Insulin/Shc 0.05 0.038 -10000 0 -0.046 57 57
RHOA 0.032 0.006 -10000 0 -10000 0 0
LEPR 0.031 0.009 -10000 0 -0.063 3 3
BCAR1 0 0 -10000 0 -10000 0 0
p210 bcr-abl/Grb2 0.032 0.006 -10000 0 -10000 0 0
mol:NADPH 0.001 0.002 -10000 0 -10000 0 0
TRPV6 0.031 0.08 0.2 25 -0.28 11 36
PRL 0.033 0.011 -10000 0 -0.06 6 6
SOCS3 0.019 0.015 -10000 0 -10000 0 0
SPRY2 0.032 0.015 -10000 0 -0.061 8 8
Insulin Receptor/Insulin/IRS1 0.06 0.024 -10000 0 -0.041 21 21
CSF1/CSF1R 0.051 0.067 0.18 6 -0.23 11 17
Ras protein signal transduction -0.012 0.082 0.51 11 -10000 0 11
IRS1 0.032 0.009 -10000 0 -0.063 4 4
INS 0.032 0.007 -10000 0 -0.026 1 1
LEP 0.023 0.015 -10000 0 -10000 0 0
STAT5B 0.023 0.075 0.17 8 -0.24 21 29
STAT5A 0.023 0.075 0.17 8 -0.24 21 29
GRB2 0.032 0.006 -10000 0 -10000 0 0
PDGFB-D/PDGFRB 0.041 0.062 0.18 8 -0.23 11 19
CSN2 0 0.034 -10000 0 -0.28 5 5
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
LAT 0.009 0.044 -10000 0 -0.29 2 2
YBX1 0.037 0.017 -10000 0 -0.061 12 12
LCK 0.031 0.01 -10000 0 -0.063 4 4
SHC1 0.024 0.026 -10000 0 -0.063 40 40
NOX4 0.022 0.033 -10000 0 -0.06 70 70
Class I PI3K signaling events mediated by Akt

Figure S49.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S49.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.021 0.006 -10000 0 -10000 0 0
BAD/BCL-XL/YWHAZ 0.043 0.017 -10000 0 -10000 0 0
CDKN1B -0.006 0.084 0.2 7 -0.33 29 36
CDKN1A -0.012 0.085 -10000 0 -0.33 32 32
FRAP1 0 0 -10000 0 -10000 0 0
PRKDC 0.028 0.019 -10000 0 -0.063 21 21
FOXO3 -0.005 0.08 0.2 4 -0.33 26 30
AKT1 -0.002 0.088 -10000 0 -0.34 31 31
BAD 0.032 0.004 -10000 0 -10000 0 0
AKT3 0.012 0.003 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
FOXO4 -0.009 0.084 -10000 0 -0.33 31 31
AKT1/ASK1 0.014 0.09 -10000 0 -0.32 33 33
BAD/YWHAZ 0.06 0.02 -10000 0 -0.036 8 8
RICTOR 0 0 -10000 0 -10000 0 0
RAF1 0.032 0.004 -10000 0 -10000 0 0
JNK cascade -0.013 0.087 0.31 33 -10000 0 33
TSC1 -0.01 0.085 0.19 1 -0.33 32 33
YWHAZ 0.032 0.006 -10000 0 -10000 0 0
AKT1/RAF1 0.016 0.093 -10000 0 -0.33 33 33
EP300 0.03 0.008 -10000 0 -10000 0 0
mol:GDP -0.002 0.087 -10000 0 -0.34 31 31
mol:PI-3-4-5-P3 0 0 -10000 0 -10000 0 0
TSC2 -0.011 0.085 -10000 0 -0.33 33 33
YWHAQ 0.032 0.004 -10000 0 -10000 0 0
TBC1D4 -0.006 0.002 -10000 0 -10000 0 0
MAP3K5 0.03 0.009 -10000 0 -10000 0 0
MAPKAP1 0.031 0.007 -10000 0 -10000 0 0
negative regulation of cell cycle 0.013 0.054 0.18 24 -0.16 2 26
YWHAH 0.015 0.016 -10000 0 0 279 279
AKT1S1 -0.003 0.084 -10000 0 -0.32 31 31
CASP9 -0.008 0.085 0.2 3 -0.33 31 34
YWHAB 0.03 0.009 -10000 0 -10000 0 0
p27Kip1/KPNA1 0.013 0.093 0.23 10 -0.32 32 42
GBL 0 0 -10000 0 -10000 0 0
PDK1/Src/Hsp90 0.055 0.029 -10000 0 -0.044 2 2
YWHAE 0.032 0.005 -10000 0 -10000 0 0
SRC 0.031 0.008 -10000 0 -10000 0 0
AKT2/p21CIP1 -0.01 0.079 0.23 1 -0.3 33 34
KIAA1303 0 0 -10000 0 -10000 0 0
mTOR/RHEB/GTP/Raptor/GBL 0.005 0.029 -10000 0 -10000 0 0
CHUK -0.004 0.062 -10000 0 -0.34 16 16
BAD/BCL-XL 0.013 0.09 -10000 0 -0.32 32 32
mTORC2 0.02 0.006 -10000 0 -0.016 8 8
AKT2 0.012 0.003 -10000 0 -10000 0 0
FOXO1-3a-4/14-3-3 family -0.026 0.08 0.17 1 -0.27 35 36
PDPK1 0.032 0.004 -10000 0 -10000 0 0
MDM2 0.006 0.099 0.2 41 -0.33 30 71
MAPKKK cascade -0.016 0.092 0.32 33 -10000 0 33
MDM2/Cbp/p300 0.038 0.11 0.22 44 -0.32 30 74
TSC1/TSC2 -0.01 0.094 0.25 12 -0.32 33 45
proteasomal ubiquitin-dependent protein catabolic process 0.036 0.1 0.21 44 -0.31 30 74
glucose import -0.01 0.019 0.2 4 -10000 0 4
mTOR/RHEB/GDP/Raptor/GBL/PRAS40 0.007 0.053 -10000 0 -0.19 33 33
response to stress 0 0 -10000 0 -10000 0 0
SLC2A4 -0.011 0.017 0.2 3 -10000 0 3
GSK3A -0.007 0.081 0.2 4 -0.33 28 32
FOXO1 -0.007 0.077 -10000 0 -0.33 26 26
GSK3B -0.008 0.086 0.2 4 -0.33 32 36
SFN 0.026 0.023 -10000 0 -0.063 31 31
G1/S transition of mitotic cell cycle -0.011 0.093 0.22 16 -0.33 33 49
p27Kip1/14-3-3 family 0.006 0.033 -10000 0 -0.26 5 5
PRKACA 0.032 0.006 -10000 0 0 17 17
KPNA1 0.032 0.005 -10000 0 -10000 0 0
HSP90AA1 0.03 0.008 -10000 0 -10000 0 0
YWHAG 0 0 -10000 0 -10000 0 0
RHEB 0.022 0.015 -10000 0 -10000 0 0
CREBBP 0.032 0.004 -10000 0 -10000 0 0
FOXM1 transcription factor network

Figure S50.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S50.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC3 -0.16 0.2 -9999 0 -0.7 14 14
PLK1 0 0.11 -9999 0 -0.86 7 7
BIRC5 -0.028 0.073 -9999 0 -10000 0 0
HSPA1B -0.16 0.2 -9999 0 -0.68 17 17
MAP2K1 -0.013 0.038 -9999 0 -10000 0 0
BRCA2 -0.16 0.2 -9999 0 -0.7 13 13
FOXM1 -0.18 0.22 -9999 0 -0.74 22 22
XRCC1 -0.16 0.2 -9999 0 -0.7 13 13
FOXM1B/p19 -0.17 0.2 -9999 0 -0.7 18 18
Cyclin D1/CDK4 -0.16 0.19 -9999 0 -0.65 15 15
CDC2 -0.17 0.2 -9999 0 -0.72 15 15
TGFA -0.16 0.19 -9999 0 -0.63 16 16
SKP2 -0.16 0.2 -9999 0 -0.71 14 14
CCNE1 0.015 0.026 -9999 0 -0.055 7 7
CKS1B -0.17 0.2 -9999 0 -0.69 20 20
RB1 -0.11 0.19 -9999 0 -0.59 47 47
FOXM1C/SP1 -0.17 0.22 -9999 0 -0.72 20 20
AURKB -0.009 0.14 -9999 0 -0.92 11 11
CENPF -0.17 0.21 -9999 0 -0.69 19 19
CDK4 -0.028 0.046 -9999 0 -0.072 248 248
MYC -0.16 0.19 -9999 0 -0.62 19 19
CHEK2 -0.012 0.04 -9999 0 -0.1 15 15
ONECUT1 -0.16 0.2 -9999 0 -0.68 15 15
CDKN2A 0.003 0.026 -9999 0 -0.061 52 52
LAMA4 -0.16 0.2 -9999 0 -0.7 14 14
FOXM1B/HNF6 -0.17 0.21 -9999 0 -0.75 15 15
FOS -0.18 0.2 -9999 0 -0.74 14 14
SP1 0.031 0.006 -9999 0 -0.025 2 2
CDC25B -0.16 0.2 -9999 0 -0.7 12 12
response to radiation -0.011 0.013 -9999 0 -10000 0 0
CENPB -0.16 0.2 -9999 0 -0.7 12 12
CENPA -0.17 0.21 -9999 0 -0.71 19 19
NEK2 -0.16 0.2 -9999 0 -0.71 14 14
HIST1H2BA -0.16 0.2 -9999 0 -0.68 17 17
CCNA2 0.001 0.046 -9999 0 -0.072 135 135
EP300 0.03 0.008 -9999 0 -10000 0 0
CCNB1/CDK1 -0.18 0.21 -9999 0 -0.76 15 15
CCNB2 -0.19 0.21 -9999 0 -0.71 19 19
CCNB1 -0.18 0.21 -9999 0 -0.72 16 16
ETV5 -0.16 0.2 -9999 0 -0.69 14 14
ESR1 -0.16 0.2 -9999 0 -0.7 14 14
CCND1 -0.16 0.2 -9999 0 -0.66 16 16
GSK3A -0.009 0.036 -9999 0 -10000 0 0
Cyclin A-E1/CDK1-2 0.013 0.06 -9999 0 -0.098 14 14
CDK2 0.014 0.03 -9999 0 -0.073 24 24
G2/M transition of mitotic cell cycle -0.014 0.016 -9999 0 -0.047 1 1
FOXM1B/Cbp/p300 -0.16 0.22 -9999 0 -0.72 16 16
GAS1 -0.17 0.2 -9999 0 -0.71 15 15
MMP2 -0.18 0.2 -9999 0 -0.7 18 18
RB1/FOXM1C -0.18 0.21 -9999 0 -0.68 22 22
CREBBP 0.032 0.004 -9999 0 -10000 0 0
Noncanonical Wnt signaling pathway

Figure S51.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S51.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC2 0 0 -10000 0 -10000 0 0
GNB1/GNG2 0.008 0.048 -10000 0 -0.14 13 13
mol:DAG -0.005 0.039 0.14 4 -0.14 11 15
PLCG1 -0.006 0.04 0.14 4 -0.14 11 15
YES1 -0.014 0.034 -10000 0 -0.12 24 24
FZD3 0.031 0.01 -10000 0 -0.063 3 3
FZD6 0.014 0.037 -10000 0 -0.063 94 94
G protein 0.01 0.06 0.17 34 -0.14 10 44
MAP3K7 -0.022 0.037 0.17 7 -0.14 9 16
mol:Ca2+ -0.005 0.039 0.14 4 -0.13 11 15
mol:IP3 -0.005 0.039 0.14 4 -0.14 11 15
NLK 0.007 0.08 -10000 0 -0.72 6 6
GNB1 0.031 0.008 -10000 0 -10000 0 0
CAMK2A -0.019 0.039 0.19 8 -0.14 9 17
MAP3K7IP1 0 0 -10000 0 -10000 0 0
Noncanonical Wnts/FZD 0 0.039 -10000 0 -0.12 23 23
CSNK1A1 0.032 0.004 -10000 0 -10000 0 0
GNAS -0.009 0.03 -10000 0 -0.13 16 16
GO:0007205 -0.009 0.034 0.14 4 -0.13 11 15
WNT6 0.032 0.002 -10000 0 -10000 0 0
WNT4 0.031 0.008 -10000 0 -0.063 2 2
NFAT1/CK1 alpha -0.006 0.053 0.2 7 -0.15 14 21
GNG2 0 0 -10000 0 -10000 0 0
WNT5A 0.003 0.044 -10000 0 -0.063 155 155
WNT11 0.032 0.007 -10000 0 -0.063 2 2
CDC42 -0.022 0.031 0.13 6 -0.13 13 19
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)

Figure S52.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S52.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MET/RANBP9 0.032 0.023 -10000 0 -0.05 2 2
CRKL 0.049 0.083 0.24 8 -0.43 5 13
mol:PIP3 0.012 0.039 -10000 0 -0.76 1 1
AKT1 0.004 0.037 -10000 0 -0.5 1 1
PTK2B 0.032 0.005 -10000 0 -10000 0 0
RAPGEF1 0.047 0.085 0.3 14 -0.38 5 19
RANBP10 0.032 0.004 -10000 0 -10000 0 0
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
HGF/MET/SHIP2 0.042 0.033 -10000 0 -0.047 4 4
MAP3K5 0.048 0.08 0.24 6 -0.38 5 11
HGF/MET/CIN85/CBL/ENDOPHILINS 0.04 0.031 -10000 0 -0.043 3 3
AP1 0.012 0.074 0.14 114 -10000 0 114
mol:SU11274 0 0 -10000 0 -10000 0 0
SHC1 0.024 0.026 -10000 0 -0.063 40 40
apoptosis -0.023 0.22 -10000 0 -0.72 42 42
STAT3 (dimer) 0.012 0.028 -10000 0 -0.17 3 3
GAB1/CRKL/SHP2/PI3K 0.079 0.081 0.3 2 -0.4 5 7
INPP5D 0 0 -10000 0 -10000 0 0
CBL/CRK 0.067 0.081 0.25 4 -0.38 6 10
PTPN11 0.032 0.003 -10000 0 -10000 0 0
GO:0007205 0 0 -10000 0 -10000 0 0
PLCG1 0.03 0.009 -10000 0 -10000 0 0
PTEN 0.023 0.016 -10000 0 -0.063 2 2
ELK1 0.11 0.18 0.35 169 -10000 0 169
mol:SU5416 0 0 -10000 0 -10000 0 0
SHP2/GRB2/SOS1GAB1 0.009 0.029 0.16 1 -0.16 10 11
PAK1 -0.001 0.041 -10000 0 -0.48 1 1
HGF/MET/RANBP10 0.042 0.033 -10000 0 -0.048 3 3
HRAS 0.015 0.039 -10000 0 -0.3 4 4
DOCK1 0.036 0.078 0.28 5 -0.38 6 11
GAB1 0.051 0.078 0.22 2 -0.47 4 6
CRK 0.052 0.081 0.23 8 -0.43 5 13
mol:PHA665752 0 0 -10000 0 -10000 0 0
mol:GDP 0.02 0.036 -10000 0 -0.32 4 4
JUN 0.032 0.005 -10000 0 -10000 0 0
EntrezGene:200958 0 0 -10000 0 -10000 0 0
HGF/MET 0.007 0.016 0.081 8 -0.051 16 24
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
cell morphogenesis 0.044 0.089 0.25 42 -0.3 3 45
GRB2/SHC 0.059 0.062 0.16 104 -0.11 10 114
FOS 0.007 0.04 -10000 0 -0.063 120 120
GLMN 0.003 0.001 -10000 0 -10000 0 0
cell motility 0.11 0.18 0.35 169 -10000 0 169
HGF/MET/MUC20 0.028 0.022 -10000 0 -0.04 3 3
cell migration 0.058 0.061 0.15 104 -0.11 10 114
GRB2 0.032 0.006 -10000 0 -10000 0 0
CBL 0.032 0.004 -10000 0 -10000 0 0
MET/RANBP10 0.032 0.023 -10000 0 -0.05 2 2
HGF/MET/Paxillin/FAK1/FAK12/RasGAP 0.016 0.021 -10000 0 -0.12 6 6
MET/MUC20 0.016 0.012 -10000 0 -0.039 2 2
RAP1B 0.046 0.081 0.29 14 -0.36 5 19
RAP1A 0.042 0.084 0.31 15 -0.38 4 19
HGF/MET/RANBP9 0.042 0.033 -10000 0 -0.042 6 6
RAF1 0.038 0.061 0.21 4 -0.28 5 9
STAT3 0.012 0.027 -10000 0 -0.2 2 2
cell proliferation 0.03 0.061 0.21 16 -0.25 2 18
RPS6KB1 0.01 0.015 -10000 0 -10000 0 0
MAPK3 0.076 0.16 0.32 112 -10000 0 112
MAPK1 0.12 0.21 0.62 42 -10000 0 42
RANBP9 0.032 0.004 -10000 0 -10000 0 0
MAPK8 -0.023 0.14 0.25 4 -0.32 52 56
SRC 0.004 0.017 -10000 0 -0.12 7 7
PI3K 0.058 0.059 0.16 96 -0.11 9 105
MET/Glomulin 0.015 0.025 0.085 1 -0.086 19 20
SOS1 0 0 -10000 0 -10000 0 0
MAP2K1 0.035 0.062 0.25 5 -0.28 4 9
MET 0.022 0.016 -10000 0 -0.063 2 2
MAP4K1 0.056 0.085 0.26 5 -0.44 5 10
PTK2 0.031 0.006 -10000 0 -10000 0 0
MAP2K2 0.04 0.073 0.28 12 -0.27 5 17
BAD -0.002 0.037 -10000 0 -0.48 1 1
MAP2K4 0.043 0.077 0.23 14 -0.34 5 19
SHP2/GRB2/SOS1/GAB1 0.028 0.052 -10000 0 -0.36 5 5
INPPL1 0.032 0.004 -10000 0 -10000 0 0
PXN 0.032 0.003 -10000 0 -10000 0 0
SH3KBP1 0 0 -10000 0 -10000 0 0
HGS -0.004 0.014 0.071 8 -0.054 16 24
PLCgamma1/PKC 0.022 0.006 -10000 0 -10000 0 0
HGF 0.022 0.016 -10000 0 -0.063 1 1
RASA1 0.032 0.006 -10000 0 -10000 0 0
NCK1 0.03 0.015 -10000 0 -0.063 11 11
PTPRJ 0.032 0.006 -10000 0 -10000 0 0
NCK/PLCgamma1 0.066 0.056 0.16 112 -0.11 10 122
PDPK1 0.011 0.036 -10000 0 -0.53 1 1
HGF/MET/SHIP 0.028 0.022 -10000 0 -0.04 3 3
ceramide signaling pathway

Figure S53.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S53.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAP4K4 -0.003 0.051 -10000 0 -0.26 9 9
BAG4 0.032 0.004 -10000 0 -10000 0 0
BAD -0.008 0.025 0.14 3 -0.12 8 11
NFKBIA 0.03 0.009 -10000 0 -0.063 1 1
BIRC3 0.026 0.023 -10000 0 -0.063 30 30
BAX -0.005 0.037 0.18 12 -0.12 8 20
EnzymeConsortium:3.1.4.12 0 0.016 0.068 3 -0.066 9 12
IKBKB -0.008 0.053 0.2 3 -0.27 8 11
MAP2K2 -0.012 0.045 0.16 24 -0.14 5 29
MAP2K1 -0.016 0.034 0.16 10 -0.14 5 15
SMPD1 -0.002 0.025 0.096 3 -0.1 17 20
GO:0005551 0 0 -10000 0 -10000 0 0
FADD/Caspase 8 0 0.056 0.29 1 -0.28 10 11
MAP2K4 -0.012 0.027 0.14 6 -0.13 6 12
protein ubiquitination -0.01 0.059 0.5 1 -0.27 9 10
EnzymeConsortium:2.7.1.37 -0.016 0.042 0.17 9 -0.15 6 15
response to UV 0 0 0.002 11 -0.002 2 13
RAF1 -0.012 0.033 0.17 8 -0.13 7 15
CRADD 0.032 0.004 -10000 0 -10000 0 0
mol:ceramide -0.002 0.025 0.1 3 -0.1 13 16
I-kappa-B-alpha/RELA/p50/ubiquitin 0.041 0.012 -10000 0 -0.04 1 1
MADD 0.031 0.006 -10000 0 0 21 21
MAP3K1 -0.008 0.027 0.15 4 -0.12 8 12
TRADD 0.032 0.004 -10000 0 -10000 0 0
RELA/p50 0.032 0.004 -10000 0 -10000 0 0
MAPK3 -0.009 0.04 0.17 10 -0.14 5 15
MAPK1 -0.016 0.047 0.17 9 -0.16 13 22
p50/RELA/I-kappa-B-alpha 0.045 0.013 -10000 0 -0.05 1 1
FADD -0.002 0.049 0.24 1 -0.27 6 7
KSR1 -0.008 0.026 0.12 4 -0.12 8 12
MAPK8 -0.012 0.031 0.18 5 -0.14 5 10
TRAF2 0.031 0.006 -10000 0 -10000 0 0
response to radiation 0 0 0.002 1 -10000 0 1
CHUK -0.009 0.049 -10000 0 -0.27 8 8
TNF R/SODD 0.014 0.045 -10000 0 -0.05 164 164
TNF 0.032 0.006 -10000 0 -0.063 2 2
CYCS 0.011 0.045 0.13 23 -0.12 5 28
IKBKG -0.008 0.053 0.19 3 -0.27 8 11
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD 0.005 0.054 0.15 1 -0.27 9 10
RELA 0.032 0.004 -10000 0 -10000 0 0
RIPK1 0.03 0.013 -10000 0 -0.063 9 9
AIFM1 -0.009 0.031 0.12 13 -0.12 6 19
TNF/TNF R/SODD 0.025 0.054 -10000 0 -0.048 172 172
TNFRSF1A 0 0.044 -10000 0 -0.063 165 165
response to heat 0 0 0.002 1 -10000 0 1
CASP8 0.027 0.073 -10000 0 -0.61 6 6
NSMAF -0.002 0.054 0.18 5 -0.27 8 13
response to hydrogen peroxide 0 0 0.002 11 -0.002 2 13
BCL2 0.032 0.006 -10000 0 0 17 17
Visual signal transduction: Cones

Figure S54.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S54.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Cone Metarhodopsin II/Cone Transducin 0.036 0.011 -10000 0 -0.022 9 9
RGS9BP 0 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
GRK1 0 0 -10000 0 -10000 0 0
mol:Na + 0.013 0.039 -10000 0 -0.039 179 179
mol:ADP 0 0 -10000 0 -10000 0 0
GNAT2 0.032 0.004 -10000 0 -10000 0 0
RGS9-1/Gbeta5/R9AP 0.042 0.01 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
PDE6H/GNAT2/GTP 0.041 0.011 -10000 0 -10000 0 0
GRK7 0 0 -10000 0 -10000 0 0
CNGB3 0.032 0.004 -10000 0 -10000 0 0
Cone Metarhodopsin II/X-Arrestin 0.024 0.002 -10000 0 -10000 0 0
mol:Ca2+ -0.02 0.033 0.18 11 -10000 0 11
Cone PDE6 0.044 0.051 -10000 0 -10000 0 0
Cone Metarhodopsin II 0 0 -10000 0 -10000 0 0
Na + (4 Units) 0.014 0.051 -10000 0 -0.044 178 178
GNAT2/GDP 0.053 0.018 -10000 0 -10000 0 0
GNB5 0.031 0.006 -10000 0 -10000 0 0
mol:GMP (4 units) -0.013 0.03 0.18 11 -10000 0 11
Cone Transducin 0.039 0.012 -10000 0 -0.023 9 9
SLC24A2 0.027 0.013 -10000 0 -10000 0 0
GNB3/GNGT2 0.023 0.005 -10000 0 -10000 0 0
GNB3 0.031 0.007 -10000 0 -10000 0 0
GNAT2/GTP 0.024 0.003 -10000 0 -10000 0 0
CNGA3 -0.001 0.045 -10000 0 -0.063 179 179
ARR3 0.032 0.002 -10000 0 -10000 0 0
absorption of light 0 0 -10000 0 -10000 0 0
cGMP/Cone CNG Channel 0.014 0.04 -10000 0 -0.04 179 179
mol:Pi 0.041 0.009 -10000 0 -10000 0 0
Cone CNG Channel 0.014 0.064 -10000 0 -10000 0 0
mol:all-trans-retinal 0 0 -10000 0 -10000 0 0
mol:K + 0.027 0.013 -10000 0 -10000 0 0
RGS9 0.032 0.004 -10000 0 -10000 0 0
PDE6C 0.024 0.014 -10000 0 -10000 0 0
GNGT2 0 0 -10000 0 -10000 0 0
mol:cGMP (4 units) 0 0 -10000 0 -10000 0 0
PDE6H 0.031 0.007 -10000 0 -10000 0 0
Arf6 downstream pathway

Figure S55.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S55.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PLAUR 0 0.037 -10000 0 -0.1 59 59
regulation of axonogenesis 0.01 0.059 0.26 26 -10000 0 26
myoblast fusion -0.014 0.038 0.35 3 -10000 0 3
mol:GTP 0.009 0.05 -10000 0 -0.18 29 29
regulation of calcium-dependent cell-cell adhesion -0.024 0.041 0.12 25 -10000 0 25
ARF1/GTP 0.027 0.047 -10000 0 -0.14 27 27
mol:GM1 -0.001 0.034 -10000 0 -0.13 29 29
mol:Choline -0.021 0.026 0.033 1 -0.13 25 26
lamellipodium assembly -0.006 0.064 -10000 0 -0.38 13 13
MAPK3 0.006 0.039 -10000 0 -0.12 29 29
ARF6/GTP/NME1/Tiam1 0.024 0.041 -10000 0 -0.12 25 25
ARF1 0.032 0.006 -10000 0 -10000 0 0
ARF6/GDP 0.014 0.038 -10000 0 -0.35 3 3
ARF1/GDP 0.008 0.067 -10000 0 -0.24 27 27
ARF6 0.033 0.024 -10000 0 -0.039 44 44
RAB11A 0.032 0.005 -10000 0 -10000 0 0
TIAM1 0.029 0.011 -10000 0 -0.031 8 8
fibronectin binding 0 0 -10000 0 -10000 0 0
MAPK1 0.008 0.034 -10000 0 -0.12 18 18
actin filament bundle formation -0.016 0.071 0.25 28 -10000 0 28
KALRN -0.001 0.047 -10000 0 -0.26 14 14
RAB11FIP3/RAB11A 0.047 0.009 -10000 0 -10000 0 0
RhoA/GDP 0.016 0.071 -10000 0 -0.25 28 28
NME1 -0.001 0.003 -10000 0 -10000 0 0
Rac1/GDP 0.013 0.055 -10000 0 -0.24 15 15
substrate adhesion-dependent cell spreading 0.009 0.05 -10000 0 -0.18 29 29
cortical actin cytoskeleton organization -0.006 0.064 -10000 0 -0.38 13 13
RAC1 0.023 0.015 -10000 0 -10000 0 0
liver development 0.009 0.05 -10000 0 -0.18 29 29
ARF6/GTP 0.009 0.05 -10000 0 -0.18 29 29
RhoA/GTP 0.027 0.047 -10000 0 -0.14 28 28
mol:GDP -0.009 0.062 -10000 0 -0.26 27 27
ARF6/GTP/RAB11FIP3/RAB11A 0.043 0.052 -10000 0 -0.13 29 29
RHOA 0.032 0.006 -10000 0 -10000 0 0
PLD1 0.005 0.039 -10000 0 -0.14 28 28
RAB11FIP3 0.032 0.004 -10000 0 -10000 0 0
tube morphogenesis -0.006 0.064 -10000 0 -0.38 13 13
ruffle organization -0.01 0.059 -10000 0 -0.26 26 26
regulation of epithelial cell migration 0.009 0.05 -10000 0 -0.18 29 29
PLD2 0.006 0.038 -10000 0 -0.14 26 26
PIP5K1A -0.011 0.06 -10000 0 -0.26 26 26
mol:Phosphatidic acid -0.021 0.026 0.033 1 -0.13 25 26
Rac1/GTP -0.006 0.065 -10000 0 -0.38 13 13
FOXA2 and FOXA3 transcription factor networks

Figure S56.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S56.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ACADVL 0.042 0.06 0.23 35 -10000 0 35
PCK1 0.037 0.031 -10000 0 -10000 0 0
HNF4A 0.035 0.043 0.24 8 -0.28 1 9
KCNJ11 0.055 0.061 0.26 28 -10000 0 28
AKT1 0.068 0.042 -10000 0 -0.25 1 1
response to starvation 0.002 0.004 -10000 0 -0.075 1 1
DLK1 0.049 0.072 0.26 32 -0.24 1 33
NKX2-1 0.04 0.048 0.21 4 -10000 0 4
ACADM 0.042 0.06 0.23 35 -10000 0 35
TAT 0.043 0.043 -10000 0 -10000 0 0
CEBPB 0.029 0.017 -10000 0 -0.061 11 11
CEBPA 0.03 0.018 -10000 0 -0.061 15 15
TTR 0.053 0.092 0.36 31 -0.44 1 32
PKLR 0.045 0.065 0.23 43 -10000 0 43
APOA1 0.06 0.071 0.39 12 -10000 0 12
CPT1C 0.044 0.056 0.24 29 -10000 0 29
ALAS1 0.047 0.058 -10000 0 -0.62 1 1
TFRC 0.055 0.051 0.2 30 -10000 0 30
FOXF1 0.023 0.024 -10000 0 -0.063 35 35
NF1 0.034 0.01 -10000 0 -0.17 1 1
HNF1A (dimer) 0.039 0.005 -10000 0 -10000 0 0
CPT1A 0.042 0.06 0.23 36 -10000 0 36
HMGCS1 0.043 0.061 0.23 37 -10000 0 37
NR3C1 0.035 0.014 -10000 0 -10000 0 0
CPT1B 0.035 0.053 0.23 24 -10000 0 24
chromatin remodeling 0 0 -10000 0 -10000 0 0
SP1 0.034 0.005 -10000 0 -10000 0 0
GCK 0.077 0.098 0.25 119 -10000 0 119
CREB1 0.035 0.009 -10000 0 -10000 0 0
IGFBP1 0.05 0.047 -10000 0 -10000 0 0
PDX1 0.045 0.052 0.18 23 -0.31 1 24
UCP2 0.037 0.066 0.23 35 -10000 0 35
ALDOB 0.061 0.071 0.26 44 -10000 0 44
AFP 0.01 0.009 -10000 0 -0.082 4 4
BDH1 0.046 0.067 0.24 45 -10000 0 45
HADH 0.059 0.068 0.26 39 -10000 0 39
F2 0.058 0.074 0.41 10 -10000 0 10
HNF1A 0.039 0.005 -10000 0 -10000 0 0
G6PC 0.021 0.03 -10000 0 -10000 0 0
SLC2A2 0.061 0.051 0.2 35 -10000 0 35
INS 0.028 0.01 0.18 1 -10000 0 1
FOXA1 0.006 0.006 -10000 0 -0.087 1 1
FOXA3 0.015 0.011 -10000 0 -0.1 3 3
FOXA2 0.09 0.071 0.29 28 -10000 0 28
ABCC8 0.058 0.066 0.25 37 -10000 0 37
ALB 0.01 0.009 -10000 0 -0.082 4 4
IFN-gamma pathway

Figure S57.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S57.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 0.05 0.051 -10000 0 -0.069 6 6
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
CRKL 0.031 0.007 -10000 0 -10000 0 0
STAT1 (dimer)/Cbp/p300 -0.043 0.053 0.2 18 -10000 0 18
IFN-gammaR/JAK1/JAK1/JAK2/JAK2 0.046 0.042 0.16 1 -0.047 78 79
antigen processing and presentation of peptide antigen via MHC class I -0.038 0.033 -10000 0 -0.1 42 42
CaM/Ca2+ 0.047 0.055 -10000 0 -0.077 1 1
RAP1A 0.032 0.004 -10000 0 0 9 9
STAT1 (dimer)/SHP2 -0.034 0.035 0.15 16 -10000 0 16
AKT1 -0.023 0.064 0.28 9 -10000 0 9
MAP2K1 -0.032 0.045 0.16 20 -10000 0 20
MAP3K11 -0.028 0.051 0.18 22 -10000 0 22
IFNGR1 0.029 0.017 0.085 3 -0.067 11 14
mol:GTP 0 0 -10000 0 -10000 0 0
CaM/Ca2+/CAMKII -0.056 0.088 -10000 0 -0.22 88 88
Rap1/GTP -0.045 0.017 -10000 0 -10000 0 0
CRKL/C3G 0.044 0.014 -10000 0 -10000 0 0
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 /TC-PTP 0.063 0.06 -10000 0 -10000 0 0
CEBPB -0.01 0.092 0.33 6 -0.28 31 37
STAT3 0.03 0.014 -10000 0 -0.063 10 10
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 0.058 0.087 -10000 0 -0.74 4 4
STAT1 -0.031 0.047 0.17 20 -10000 0 20
CALM1 0.029 0.01 -10000 0 -10000 0 0
IFN-gamma (dimer) 0.03 0.01 -10000 0 -0.029 5 5
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
STAT1 (dimer)/PIAS1 -0.034 0.05 0.18 20 -10000 0 20
CEBPB/PTGES2/Cbp/p300 0.006 0.073 0.15 1 -0.22 34 35
mol:Ca2+ 0.047 0.049 -10000 0 -0.068 6 6
MAPK3 -0.002 0.059 0.51 1 -0.57 2 3
STAT1 (dimer) -0.048 0.044 0.08 3 -0.14 27 30
MAPK1 -0.051 0.19 0.46 2 -0.67 40 42
JAK2 0.03 0.012 0.085 3 -10000 0 3
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
JAK1 0.031 0.01 0.07 1 -0.029 6 7
CAMK2D 0 0 -10000 0 -10000 0 0
DAPK1 -0.004 0.071 0.28 8 -0.19 31 39
SMAD7 -0.016 0.041 0.14 15 -0.082 4 19
CBL/CRKL/C3G -0.037 0.052 0.19 20 -10000 0 20
PI3K 0.041 0.056 -10000 0 -10000 0 0
IFNG 0.03 0.01 -10000 0 -0.029 5 5
apoptosis 0.001 0.066 0.32 5 -0.38 3 8
CAMK2G 0.012 0.016 -10000 0 0 319 319
STAT3 (dimer) 0.03 0.014 -10000 0 -0.063 10 10
CAMK2A 0.031 0.007 -10000 0 0 26 26
CAMK2B 0.003 0.009 -10000 0 -10000 0 0
FRAP1 -0.023 0.058 0.26 9 -10000 0 9
PRKCD -0.025 0.067 0.28 10 -10000 0 10
RAP1B 0 0 -10000 0 -10000 0 0
negative regulation of cell growth -0.038 0.033 -10000 0 -0.1 42 42
PTPN2 0.031 0.006 -10000 0 -10000 0 0
EP300 0.03 0.008 -10000 0 -10000 0 0
IRF1 -0.042 0.052 0.3 6 -10000 0 6
STAT1 (dimer)/PIASy -0.035 0.047 0.17 19 -10000 0 19
SOCS1 0.017 0.093 -10000 0 -1 4 4
mol:GDP -0.036 0.049 0.18 20 -10000 0 20
CASP1 -0.02 0.045 0.14 17 -0.088 11 28
PTGES2 0.031 0.006 -10000 0 -10000 0 0
IRF9 -0.008 0.041 0.18 8 -0.11 17 25
mol:PI-3-4-5-P3 0.028 0.047 -10000 0 -0.075 8 8
RAP1/GDP -0.043 0.029 0.1 14 -10000 0 14
CBL -0.028 0.051 0.18 22 -10000 0 22
MAP3K1 -0.029 0.045 0.17 20 -10000 0 20
PIAS1 0.032 0.004 -10000 0 0 9 9
PIAS4 0.031 0.006 -10000 0 -10000 0 0
antigen processing and presentation of peptide antigen via MHC class II -0.038 0.033 -10000 0 -0.1 42 42
PTPN11 -0.025 0.044 0.16 23 -10000 0 23
CREBBP 0.032 0.004 -10000 0 -10000 0 0
RAPGEF1 0.031 0.006 -10000 0 -10000 0 0
EGFR-dependent Endothelin signaling events

Figure S58.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S58.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HRAS 0.031 0.007 -9999 0 -10000 0 0
EGFR 0.012 0.018 -9999 0 -0.063 6 6
EGF/EGFR 0.007 0.035 -9999 0 -0.056 8 8
EGF/EGFR dimer/SHC/GRB2/SOS1 0.021 0.04 -9999 0 -0.059 2 2
mol:GTP 0 0 -9999 0 -10000 0 0
EDNRA 0.005 0.043 -9999 0 -0.063 146 146
response to oxidative stress 0 0 -9999 0 -10000 0 0
EGF 0.032 0.007 -9999 0 -0.063 2 2
EGF/EGFR dimer/SHC 0.018 0.035 -9999 0 -0.049 33 33
mol:GDP 0.019 0.037 -9999 0 -0.058 2 2
mol:Ca2+ 0 0 -9999 0 -10000 0 0
EDN1 0.03 0.013 -9999 0 -0.063 9 9
GRB2/SOS1 0.023 0.004 -9999 0 -10000 0 0
HRAS/GTP 0.011 0.03 -9999 0 -0.059 3 3
SHC1 0.024 0.026 -9999 0 -0.063 40 40
HRAS/GDP 0.017 0.038 -9999 0 -0.067 1 1
FRAP1 -0.012 0.015 -9999 0 -0.056 2 2
EGF/EGFR dimer 0.018 0.025 -9999 0 -0.05 8 8
SOS1 0 0 -9999 0 -10000 0 0
GRB2 0.032 0.006 -9999 0 -10000 0 0
ETA receptor/Endothelin-1 0.018 0.045 -9999 0 -0.05 149 149
Aurora A signaling

Figure S59.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S59.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Aurora A/GADD45A 0.028 0.033 -10000 0 -0.12 8 8
BIRC5 -0.006 0.046 -10000 0 -0.063 202 202
NFKBIA -0.006 0.015 0.17 2 -10000 0 2
CPEB1 0.024 0.014 -10000 0 -10000 0 0
AKT1 -0.006 0.015 0.14 3 -10000 0 3
NDEL1 0.031 0.008 -10000 0 -10000 0 0
Aurora A/BRCA1 0.025 0.024 0.099 2 -0.12 8 10
NDEL1/TACC3 0.033 0.039 -10000 0 -0.12 8 8
GADD45A 0.024 0.026 -10000 0 -0.063 39 39
GSK3B 0.032 0.007 0.082 2 -10000 0 2
PAK1/Aurora A 0.034 0.029 -10000 0 -0.12 8 8
MDM2 0.029 0.011 -10000 0 -0.063 1 1
JUB 0 0 -10000 0 -10000 0 0
TPX2 -0.034 0.017 -10000 0 -0.05 254 254
TP53 0.009 0.034 -10000 0 -0.2 10 10
DLG7 0.006 0.009 0.096 2 -0.033 1 3
AURKAIP1 0.031 0.007 -10000 0 -10000 0 0
ARHGEF7 0.031 0.007 -10000 0 -10000 0 0
G2 phase of mitotic cell cycle 0 0 -10000 0 -10000 0 0
Aurora A/NDEL1/TACC3 0.035 0.042 -10000 0 -0.13 8 8
G2/M transition of mitotic cell cycle 0.024 0.024 0.098 2 -0.11 8 10
AURKA 0.014 0.013 0.13 2 -0.042 1 3
AURKB 0.007 0.025 -10000 0 -0.1 18 18
CDC25B 0.012 0.019 0.097 2 -0.21 2 4
G2/M transition checkpoint 0.007 0.017 0.076 2 -0.1 8 10
mRNA polyadenylation 0.019 0.021 0.098 1 -0.11 5 6
Aurora A/CPEB 0.019 0.021 0.099 1 -0.11 5 6
Aurora A/TACC1/TRAP/chTOG 0.065 0.037 -10000 0 -0.12 7 7
BRCA1 0.031 0.01 -10000 0 -0.063 5 5
centrosome duplication 0.034 0.029 -10000 0 -0.12 8 8
regulation of centrosome cycle 0.032 0.039 -10000 0 -0.12 8 8
spindle assembly 0.063 0.036 -10000 0 -0.12 7 7
TDRD7 0.031 0.006 -10000 0 -10000 0 0
Aurora A/RasGAP/Survivin 0.025 0.054 -10000 0 -0.13 8 8
CENPA 0.01 0.024 -10000 0 -0.24 2 2
Aurora A/PP2A 0.035 0.027 -10000 0 -0.12 5 5
meiosis 0 0 -10000 0 -10000 0 0
protein catabolic process 0.001 0.03 0.089 5 -0.19 8 13
negative regulation of DNA binding 0.009 0.034 -10000 0 -0.2 10 10
prophase 0 0 -10000 0 -10000 0 0
GIT1/beta-PIX 0.045 0.012 -10000 0 -10000 0 0
RASA1 0.032 0.006 -10000 0 -10000 0 0
Ajuba/Aurora A 0.007 0.017 0.076 2 -0.1 8 10
mitotic prometaphase -0.002 0.012 0.071 11 -10000 0 11
proteasomal ubiquitin-dependent protein catabolic process 0.014 0.013 0.13 2 -0.041 1 3
TACC1 0.032 0.004 -10000 0 -10000 0 0
TACC3 0.015 0.037 -10000 0 -0.063 92 92
Aurora A/Antizyme1 0.049 0.031 -10000 0 -0.12 8 8
Aurora A/RasGAP 0.034 0.029 -10000 0 -0.13 7 7
OAZ1 0.031 0.006 -10000 0 -10000 0 0
RAN 0.032 0.004 -10000 0 -10000 0 0
mitosis 0 0 -10000 0 -10000 0 0
PRKACA 0.031 0.008 0.082 2 -10000 0 2
GIT1 0.032 0.004 -10000 0 -10000 0 0
GIT1/beta-PIX/PAK1 0.06 0.024 -10000 0 -0.044 2 2
Importin alpha/Importin beta/TPX2 -0.034 0.017 -10000 0 -0.05 254 254
PPP2R5D 0.032 0.004 -10000 0 -10000 0 0
Aurora A/TPX2 -0.025 0.02 -10000 0 -0.14 8 8
PAK1 0.032 0.004 -10000 0 -10000 0 0
CKAP5 0.032 0.006 -10000 0 -10000 0 0
Nectin adhesion pathway

Figure S60.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S60.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB 0.032 0.007 -10000 0 -0.063 2 2
alphaV beta3 Integrin 0.045 0.018 -10000 0 -0.05 15 15
PTK2 0.016 0.078 -10000 0 -0.23 40 40
positive regulation of JNK cascade 0.021 0.081 -10000 0 -0.26 27 27
CDC42/GDP 0.035 0.11 0.35 2 -0.35 29 31
Rac1/GDP 0.024 0.093 0.29 1 -0.34 17 18
RAP1B 0 0 -10000 0 -10000 0 0
RAP1A 0.032 0.004 -10000 0 0 9 9
CTNNB1 0.032 0.005 -10000 0 -10000 0 0
CDC42/GTP 0.028 0.099 -10000 0 -0.31 27 27
nectin-3/I-afadin 0.044 0.015 -10000 0 -0.05 1 1
RAPGEF1 0.006 0.11 0.24 6 -0.34 39 45
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.004 0.11 -10000 0 -0.37 39 39
PDGFB-D/PDGFRB 0.032 0.007 -10000 0 -0.063 2 2
TLN1 -0.015 0.015 -10000 0 -0.075 19 19
Rap1/GTP 0.001 0.077 -10000 0 -0.26 38 38
IQGAP1 0.01 0.04 -10000 0 -0.063 120 120
Rap1/GTP/I-afadin 0.036 0.018 -10000 0 -0.023 40 40
nectin-3(dimer)/I-afadin/I-afadin/nectin-3(dimer)/I-afadin/I-afadin 0.044 0.015 -10000 0 -0.05 1 1
PVR 0.031 0.007 -10000 0 -10000 0 0
Necl-5(dimer) 0.031 0.007 -10000 0 -10000 0 0
mol:GDP 0.021 0.13 0.33 3 -0.41 30 33
MLLT4 0.03 0.008 -10000 0 -10000 0 0
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
PI3K 0.07 0.052 -10000 0 -10000 0 0
nectin-1(dimer)/I-afadin/I-afadin/nectin-1(dimer)/I-afadin/I-afadin 0.044 0.014 -10000 0 -10000 0 0
positive regulation of lamellipodium assembly 0.015 0.076 -10000 0 -0.29 17 17
PVRL1 0.032 0.004 -10000 0 0 9 9
PVRL3 0.032 0.006 -10000 0 -0.063 1 1
PVRL2 0.031 0.007 -10000 0 -10000 0 0
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
CDH1 0.03 0.013 -10000 0 -0.063 8 8
CLDN1 0.03 0.014 -10000 0 -0.023 25 25
JAM-A/CLDN1 0.062 0.047 -10000 0 -0.066 12 12
SRC 0.01 0.12 -10000 0 -0.4 39 39
ITGB3 0.032 0.003 -10000 0 -10000 0 0
nectin-1(dimer)/I-afadin/I-afadin 0.044 0.014 -10000 0 -10000 0 0
FARP2 0.026 0.12 0.37 1 -0.43 15 16
RAC1 0.023 0.015 -10000 0 -10000 0 0
CTNNA1 0.032 0.004 -10000 0 -10000 0 0
nectin-3(dimer)/I-afadin/I-afadin/Necl-5(dimer) 0.055 0.031 -10000 0 -0.045 10 10
nectin-1/I-afadin 0.044 0.014 -10000 0 -10000 0 0
nectin-2/I-afadin 0.043 0.015 -10000 0 -10000 0 0
RAC1/GTP/IQGAP1/filamentous actin 0.016 0.032 -10000 0 -0.04 89 89
nectin-1(dimer)/I-afadin/I-afadin/nectin-3(dimer/I-afadin/I-afadin 0.056 0.03 -10000 0 -0.036 46 46
CDC42/GTP/IQGAP1/filamentous actin 0.023 0.035 -10000 0 -0.04 118 118
F11R 0.026 0.023 -10000 0 -0.063 31 31
positive regulation of filopodium formation 0.021 0.081 -10000 0 -0.26 27 27
alphaV/beta3 Integrin/Talin 0.024 0.065 0.2 27 -0.17 9 36
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.043 0.015 -10000 0 -10000 0 0
nectin-2(dimer)/I-afadin/I-afadin 0.043 0.015 -10000 0 -10000 0 0
PIP5K1C -0.011 0.014 -10000 0 -0.062 32 32
VAV2 0.021 0.14 0.31 2 -0.46 24 26
RAP1/GDP 0.025 0.1 0.32 2 -0.31 34 36
ITGAV 0.03 0.016 -10000 0 -0.063 15 15
nectin-3(dimer)/I-afadin/I-afadin/nectin-2(dimer)/I-afadin/I-afadin 0.055 0.031 -10000 0 -0.045 10 10
nectin-3(dimer)/I-afadin/I-afadin 0.044 0.015 -10000 0 -0.05 1 1
Rac1/GTP 0.021 0.092 0.25 1 -0.35 17 18
PTPRM 0.006 0.019 -10000 0 -0.061 35 35
E-cadherin/beta catenin/alpha catenin 0.075 0.052 -10000 0 -10000 0 0
adherens junction assembly 0 0 -10000 0 -10000 0 0
CDC42 0.031 0.006 -10000 0 -10000 0 0
TRAIL signaling pathway

Figure S61.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S61.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TNFSF10 0.024 0.027 -10000 0 -0.063 45 45
positive regulation of NF-kappaB transcription factor activity 0.038 0.028 -10000 0 -0.049 44 44
MAP2K4 0.008 0.037 0.2 2 -0.16 11 13
IKBKB 0.032 0.003 -10000 0 -10000 0 0
TNFRSF10B 0.031 0.01 -10000 0 -0.063 5 5
TNFRSF10A 0 0 -10000 0 -10000 0 0
SMPD1 0.007 0.013 -10000 0 -0.058 7 7
IKBKG 0.032 0.003 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
TNFRSF10D 0.032 0.005 -10000 0 -10000 0 0
TRAIL/TRAILR2 0.037 0.03 -10000 0 -0.05 48 48
TRAIL/TRAILR3 0.038 0.029 -10000 0 -0.05 44 44
TRAIL/TRAILR1 0.018 0.018 -10000 0 -0.039 45 45
TRAIL/TRAILR4 0.038 0.029 -10000 0 -0.05 44 44
TRAIL/TRAILR1/DAP3/GTP 0.033 0.023 -10000 0 -0.034 46 46
IKK complex -0.034 0.11 -10000 0 -0.23 123 123
RIPK1 0.03 0.013 -10000 0 -0.063 9 9
response to oxidative stress 0 0 -10000 0 -10000 0 0
DAP3/GTP 0.024 0.004 -10000 0 -10000 0 0
MAPK3 -0.024 0.009 -10000 0 -0.049 45 45
MAP3K1 0.014 0.035 -10000 0 -0.14 20 20
TRAILR4 (trimer) 0.032 0.005 -10000 0 -10000 0 0
TRADD 0.032 0.004 -10000 0 -10000 0 0
TRAILR1 (trimer) 0 0 -10000 0 -10000 0 0
TRAIL/TRAILR1/FADD/TRADD/RIP/TRAF2 0.012 0.029 -10000 0 -0.11 20 20
CFLAR 0.032 0.01 -10000 0 -0.063 5 5
MAPK1 -0.022 0.01 -10000 0 -0.049 40 40
TRAIL/TRAILR1/FADD/TRADD/RIP 0.059 0.043 -10000 0 -0.064 3 3
mol:ceramide 0.007 0.013 -10000 0 -0.058 7 7
FADD 0.032 0.006 -10000 0 -0.063 1 1
MAPK8 -0.001 0.031 0.19 1 -0.16 9 10
TRAF2 0.031 0.006 -10000 0 -10000 0 0
TRAILR3 (trimer) 0.032 0.005 -10000 0 -10000 0 0
CHUK 0.024 0.015 -10000 0 -0.063 1 1
TRAIL/TRAILR1/FADD 0.035 0.025 -10000 0 -0.04 45 45
DAP3 0.032 0.005 -10000 0 -10000 0 0
CASP10 -0.013 0.026 0.14 10 -0.092 7 17
JNK cascade 0.038 0.028 -10000 0 -0.049 44 44
TRAIL (trimer) 0.023 0.027 -10000 0 -0.063 45 45
TNFRSF10C 0.032 0.005 -10000 0 -10000 0 0
TRAIL/TRAILR1/DAP3/GTP/FADD 0.046 0.031 -10000 0 -0.04 44 44
TRAIL/TRAILR2/FADD 0.051 0.038 -10000 0 -0.049 49 49
cell death 0.007 0.012 -10000 0 -0.058 7 7
TRAIL/TRAILR2/FADD/TRADD/RIP/TRAF2 0.015 0.033 -10000 0 -0.11 22 22
TRAILR2 (trimer) 0.031 0.01 -10000 0 -0.063 5 5
CASP8 0.016 0.021 -10000 0 -10000 0 0
negative regulation of caspase activity 0 0 -10000 0 -10000 0 0
TRAIL/TRAILR2/FADD/TRADD/RIP 0.072 0.055 -10000 0 -10000 0 0
Signaling events mediated by HDAC Class I

Figure S62.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S62.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NF kappa B/RelA 0.022 0.071 -10000 0 -0.14 22 22
Ran/GTP/Exportin 1/HDAC1 -0.026 0.007 -10000 0 -10000 0 0
NF kappa B1 p50/RelA/I kappa B alpha 0.002 0.062 0.16 1 -0.2 18 19
SUMO1 0.033 0.001 -10000 0 -10000 0 0
ZFPM1 0 0 -10000 0 -10000 0 0
NPC/RanGAP1/SUMO1/Ubc9 0.003 0.028 -10000 0 -0.095 39 39
FKBP3 0.03 0.008 -10000 0 -10000 0 0
Histones 0.032 0.044 -10000 0 -0.2 7 7
YY1/LSF 0.012 0.061 -10000 0 -0.15 59 59
SMG5 0.032 0.005 -10000 0 -10000 0 0
RAN 0.032 0.004 -10000 0 -10000 0 0
I kappa B alpha/HDAC3 -0.001 0.036 -10000 0 -0.1 32 32
I kappa B alpha/HDAC1 0 0.059 -10000 0 -0.18 34 34
SAP18 0.031 0.008 -10000 0 -10000 0 0
RELA 0 0.05 0.11 13 -0.15 37 50
HDAC1/Smad7 0.035 0.04 -10000 0 -0.047 47 47
RANGAP1 0.03 0.008 -10000 0 -10000 0 0
HDAC3/TR2 0.016 0.044 -10000 0 -0.21 8 8
NuRD/MBD3 Complex 0.002 0.048 -10000 0 -0.16 28 28
NF kappa B1 p50/RelA 0.016 0.059 0.17 1 -0.2 16 17
EntrezGene:23225 0 0 -10000 0 -10000 0 0
GATA2 0.032 0.005 -10000 0 -10000 0 0
GATA1 0.032 0.002 -10000 0 -10000 0 0
Mad/Max 0.045 0.012 -10000 0 -10000 0 0
NuRD/MBD3 Complex/GATA1/Fog1 0.002 0.048 -10000 0 -0.16 24 24
RBBP7 0.032 0.002 -10000 0 -10000 0 0
NPC 0.019 0.001 -10000 0 -10000 0 0
RBBP4 0.015 0.036 -10000 0 -0.063 89 89
MAX 0.03 0.008 -10000 0 -10000 0 0
EntrezGene:9972 0 0 -10000 0 -10000 0 0
FBXW11 0.032 0.005 -10000 0 -10000 0 0
NFKBIA 0.006 0.019 -10000 0 -0.055 5 5
KAT2B 0 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
SIN3/HDAC complex -0.006 0.052 -10000 0 -0.13 59 59
SIN3 complex 0.053 0.028 -10000 0 -0.039 5 5
SMURF1 0.023 0.015 -10000 0 -10000 0 0
CHD3 0.032 0.005 -10000 0 -10000 0 0
SAP30 0.032 0.006 -10000 0 -10000 0 0
EntrezGene:23636 0 0 -10000 0 -10000 0 0
NCOR1 0.032 0.004 -10000 0 -10000 0 0
YY1/HDAC3 -0.003 0.051 -10000 0 -0.18 24 24
YY1/HDAC2 0.012 0.06 -10000 0 -0.15 54 54
YY1/HDAC1 0.007 0.061 -10000 0 -0.15 55 55
NuRD/MBD2 Complex (MeCP1) 0.002 0.052 -10000 0 -0.16 29 29
PPARG 0.004 0.038 0.12 11 -0.15 14 25
HDAC8/hEST1B 0.042 0.01 -10000 0 -10000 0 0
UBE2I 0.032 0.003 -10000 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.032 0.005 -10000 0 -10000 0 0
TNFRSF1A 0 0.044 -10000 0 -0.063 165 165
HDAC3/SMRT (N-CoR2) 0.016 0.044 -10000 0 -0.21 8 8
MBD3L2 0 0 -10000 0 -10000 0 0
ubiquitin-dependent protein catabolic process 0.035 0.039 -10000 0 -0.047 47 47
CREBBP 0.032 0.004 -10000 0 -10000 0 0
NuRD/MBD3/MBD3L2 Complex 0.003 0.047 -10000 0 -0.15 23 23
HDAC1 0.02 0.031 -10000 0 -0.063 61 61
HDAC3 0.007 0.02 -10000 0 -0.059 7 7
HDAC2 0.03 0.012 -10000 0 -0.063 4 4
YY1 0.01 0.004 -10000 0 -10000 0 0
HDAC8 0 0 -10000 0 -10000 0 0
SMAD7 0.031 0.007 -10000 0 -0.063 1 1
NCOR2 0.032 0.004 -10000 0 -10000 0 0
MXD1 0.033 0.001 -10000 0 -10000 0 0
STAT3 0.017 0.009 -10000 0 -0.035 8 8
NFKB1 0.031 0.009 -10000 0 -0.063 4 4
EntrezGene:8021 0 0 -10000 0 -10000 0 0
RANBP2 0.032 0.002 -10000 0 -10000 0 0
YY1/LSF/HDAC1 0.021 0.066 -10000 0 -0.14 58 58
YY1/SAP30/HDAC1 0.02 0.067 -10000 0 -0.14 59 59
EP300 0.03 0.008 -10000 0 -10000 0 0
STAT3 (dimer non-phopshorylated) 0.017 0.009 -10000 0 -0.035 8 8
proteasomal ubiquitin-dependent protein catabolic process 0.006 0.019 -10000 0 -0.055 5 5
histone deacetylation 0.002 0.051 -10000 0 -0.16 29 29
STAT3 (dimer non-phopshorylated)/HDAC3 0.012 0.041 -10000 0 -0.15 14 14
nuclear export -0.041 0.01 -10000 0 -10000 0 0
PRKACA 0.032 0.006 -10000 0 0 17 17
GATAD2B 0 0 -10000 0 -10000 0 0
GATAD2A 0.023 0.027 -10000 0 -0.063 43 43
GATA2/HDAC3 0.016 0.044 -10000 0 -0.21 8 8
GATA1/HDAC1 0.035 0.032 -10000 0 -0.05 61 61
GATA1/HDAC3 0.016 0.045 -10000 0 -0.21 8 8
CHD4 0.031 0.007 -10000 0 -10000 0 0
TNF-alpha/TNFR1A 0.014 0.045 -10000 0 -0.05 166 166
SIN3/HDAC complex/Mad/Max -0.006 0.067 -10000 0 -0.18 47 47
NuRD Complex 0.004 0.051 -10000 0 -0.16 25 25
positive regulation of chromatin silencing 0.031 0.042 -10000 0 -0.2 7 7
SIN3B 0.031 0.006 -10000 0 -10000 0 0
MTA2 0.032 0.004 -10000 0 -10000 0 0
SIN3A 0 0 -10000 0 -10000 0 0
XPO1 0.033 0.001 -10000 0 -10000 0 0
SUMO1/HDAC1 0.03 0.043 -10000 0 -0.1 38 38
HDAC complex 0.04 0.063 -10000 0 -0.066 28 28
GATA1/Fog1 0.024 0.002 -10000 0 -10000 0 0
FKBP25/HDAC1/HDAC2 0.04 0.046 -10000 0 -0.044 112 112
TNF 0.032 0.006 -10000 0 -0.063 2 2
negative regulation of cell growth -0.006 0.067 -10000 0 -0.18 47 47
NuRD/MBD2/PRMT5 Complex 0.002 0.052 -10000 0 -0.16 29 29
Ran/GTP/Exportin 1 0.037 0.039 -10000 0 -0.096 39 39
NF kappa B/RelA/I kappa B alpha -0.005 0.049 -10000 0 -0.17 26 26
SIN3/HDAC complex/NCoR1 0.006 0.044 -10000 0 -0.17 21 21
TFCP2 0.032 0.005 -10000 0 -10000 0 0
NR2C1 0.032 0.004 -10000 0 -10000 0 0
MBD3 0.031 0.006 -10000 0 -10000 0 0
MBD2 0.032 0.006 -10000 0 -10000 0 0
FoxO family signaling

Figure S63.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S63.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
G6PC -0.014 0.05 0.24 1 -0.28 1 2
PLK1 -0.052 0.081 -10000 0 -0.36 5 5
CDKN1B -0.09 0.15 0.22 3 -0.33 128 131
FOXO3 -0.049 0.082 -10000 0 -0.32 16 16
KAT2B -0.003 0.005 -10000 0 -10000 0 0
FOXO1/SIRT1 0.005 0.053 -10000 0 -0.19 23 23
CAT -0.049 0.077 -10000 0 -0.33 9 9
CTNNB1 0.032 0.005 -10000 0 -10000 0 0
AKT1 0.016 0.026 -10000 0 -10000 0 0
FOXO1 -0.012 0.057 0.29 1 -0.2 24 25
MAPK10 0.021 0.072 0.18 85 -10000 0 85
mol:GTP 0 0.001 -10000 0 -10000 0 0
FOXO4 -0.001 0.08 0.31 5 -0.24 1 6
response to oxidative stress -0.002 0.005 -10000 0 -10000 0 0
FOXO3A/SIRT1 -0.035 0.084 -10000 0 -0.3 18 18
XPO1 0.033 0.001 -10000 0 -10000 0 0
EP300 0.03 0.009 -10000 0 -10000 0 0
BCL2L11 0.019 0.012 -10000 0 -10000 0 0
FOXO1/SKP2 0.006 0.059 0.24 1 -0.19 22 23
mol:GDP -0.002 0.005 -10000 0 -10000 0 0
RAN 0.032 0.004 -10000 0 -10000 0 0
GADD45A -0.065 0.15 0.34 1 -0.4 40 41
YWHAQ 0.032 0.004 -10000 0 -10000 0 0
FOXO1/14-3-3 family -0.021 0.078 -10000 0 -0.25 29 29
MST1 0.015 0.028 -10000 0 -0.066 6 6
CSNK1D 0.032 0.007 -10000 0 -0.063 2 2
CSNK1E 0.03 0.008 -10000 0 -10000 0 0
FOXO4/14-3-3 family -0.047 0.09 -10000 0 -0.3 23 23
YWHAB 0.03 0.009 -10000 0 -10000 0 0
MAPK8 0.012 0.071 0.18 73 -10000 0 73
MAPK9 0.039 0.095 0.18 153 -10000 0 153
YWHAG 0 0 -10000 0 -10000 0 0
YWHAE 0.032 0.005 -10000 0 -10000 0 0
YWHAZ 0.032 0.006 -10000 0 -10000 0 0
SIRT1 0.023 0.015 -10000 0 -0.025 9 9
SOD2 -0.093 0.12 0.46 1 -0.41 41 42
RBL2 -0.028 0.1 -10000 0 -0.7 7 7
RAL/GDP 0.027 0.023 -10000 0 -10000 0 0
CHUK 0.009 0.025 -10000 0 -0.059 1 1
Ran/GTP 0.023 0.004 -10000 0 -10000 0 0
CSNK1G2 0.031 0.006 -10000 0 -10000 0 0
RAL/GTP 0.024 0.023 -10000 0 -10000 0 0
CSNK1G1 0.032 0.005 -10000 0 -10000 0 0
FASLG 0.016 0.032 -10000 0 -0.61 1 1
SKP2 0.032 0.007 -10000 0 -0.063 2 2
USP7 0.032 0.003 -10000 0 -10000 0 0
IKBKB 0.016 0.027 -10000 0 -10000 0 0
CCNB1 -0.073 0.09 -10000 0 -0.37 10 10
FOXO1-3a-4/beta catenin -0.027 0.081 0.21 1 -0.3 3 4
proteasomal ubiquitin-dependent protein catabolic process 0.006 0.059 0.24 1 -0.19 22 23
CSNK1A1 0.032 0.004 -10000 0 -10000 0 0
SGK1 -0.003 0.005 -10000 0 -10000 0 0
CSNK1G3 0.032 0.004 -10000 0 -10000 0 0
Ran/GTP/Exportin 1 0.043 0.006 -10000 0 -10000 0 0
ZFAND5 0.003 0.082 0.32 10 -10000 0 10
SFN 0.026 0.023 -10000 0 -0.063 31 31
CDK2 0.028 0.021 -10000 0 -0.06 24 24
FOXO3A/14-3-3 -0.048 0.076 -10000 0 -0.25 28 28
CREBBP 0.033 0.004 -10000 0 -10000 0 0
FBXO32 -0.047 0.076 -10000 0 -0.31 12 12
BCL6 -0.032 0.1 -10000 0 -0.67 7 7
RALB 0.032 0.005 -10000 0 -0.062 1 1
RALA 0.021 0.019 -10000 0 -0.063 11 11
YWHAH 0.015 0.016 -10000 0 0 279 279
Paxillin-dependent events mediated by a4b1

Figure S64.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S64.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CRKL 0.031 0.007 -10000 0 -10000 0 0
Rac1/GDP 0.025 0.018 -10000 0 -0.026 4 4
DOCK1 0.023 0.015 -10000 0 -10000 0 0
ITGA4 0.031 0.01 -10000 0 -0.063 5 5
RAC1 0.023 0.015 -10000 0 -10000 0 0
alpha4/beta7 Integrin 0.046 0.013 -10000 0 -0.06 5 5
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.032 0.005 -10000 0 -10000 0 0
alpha4/beta1 Integrin 0.042 0.043 -10000 0 -0.036 108 108
alpha4/beta7 Integrin/Paxillin 0.046 0.015 -10000 0 -0.058 5 5
lamellipodium assembly -0.011 0.081 -10000 0 -0.34 18 18
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
PI3K 0.039 0.023 -10000 0 -0.05 16 16
ARF6 0.031 0.008 -10000 0 -10000 0 0
TLN1 0.021 0.027 -10000 0 -0.063 43 43
PXN -0.022 0.005 -10000 0 -10000 0 0
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
ARF6/GTP 0.04 0.05 0.15 7 -10000 0 7
cell adhesion 0.031 0.053 0.16 6 -0.069 2 8
CRKL/CBL 0.045 0.012 -10000 0 -10000 0 0
alpha4/beta1 Integrin/Paxillin 0.037 0.023 -10000 0 -0.052 5 5
ITGB1 0.025 0.014 -10000 0 -10000 0 0
ITGB7 0.032 0.008 -10000 0 -0.063 2 2
ARF6/GDP 0.033 0.013 -10000 0 -0.026 7 7
alpha4/beta1 Integrin/Paxillin/VCAM1 -0.021 0.054 0.17 3 -0.071 2 5
p130Cas/Crk/Dock1 0.031 0.02 -10000 0 -10000 0 0
VCAM1 -0.03 0.045 -10000 0 -0.063 333 333
alpha4/beta1 Integrin/Paxillin/Talin 0.033 0.054 0.17 6 -0.07 2 8
alpha4/beta1 Integrin/Paxillin/GIT1 0.044 0.048 0.17 7 -10000 0 7
BCAR1 0 0 -10000 0 -10000 0 0
mol:GDP -0.042 0.047 -10000 0 -0.16 7 7
CBL 0.032 0.004 -10000 0 -10000 0 0
PRKACA 0.032 0.006 -10000 0 0 17 17
GIT1 0.032 0.004 -10000 0 -10000 0 0
alpha4/beta1 Integrin/Paxillin/Talin/Actin Cytoskeleton 0.033 0.054 0.17 6 -0.07 2 8
Rac1/GTP -0.013 0.089 -10000 0 -0.38 18 18
TCR signaling in naïve CD8+ T cells

Figure S65.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S65.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GRB2/SOS1/SHC 0.02 0.051 0.21 10 -0.23 7 17
FYN 0.002 0.057 0.21 7 -0.25 9 16
LAT/GRAP2/SLP76 0.023 0.051 0.2 3 -0.25 7 10
IKBKB 0.032 0.003 -10000 0 -10000 0 0
AKT1 0.001 0.06 0.19 10 -0.23 11 21
B2M 0.032 0.006 -10000 0 -10000 0 0
IKBKG -0.01 0.023 0.084 12 -0.087 5 17
MAP3K8 0.018 0.026 -10000 0 -0.063 37 37
mol:Ca2+ -0.011 0.009 -10000 0 -0.039 2 2
integrin-mediated signaling pathway 0.021 0.003 -10000 0 0 9 9
LAT/GRAP2/SLP76/VAV1/PI3K Class IA 0.003 0.066 0.24 6 -0.25 12 18
TRPV6 0.38 0.59 1.3 155 -10000 0 155
CD28 0.033 0.002 -10000 0 -10000 0 0
SHC1 0.007 0.052 0.24 9 -0.27 6 15
receptor internalization 0.014 0.05 -10000 0 -0.36 6 6
PRF1 -0.13 0.27 -10000 0 -0.6 126 126
KRAS 0.031 0.008 -10000 0 -10000 0 0
GRB2 0.032 0.006 -10000 0 -10000 0 0
COT/AKT1 0.007 0.05 0.17 5 -0.2 11 16
LAT 0.007 0.049 0.19 5 -0.28 7 12
EntrezGene:6955 0 0.001 -10000 0 -10000 0 0
CD3D 0.029 0.019 -10000 0 -0.064 20 20
CD3E 0.032 0.006 -10000 0 -0.064 1 1
CD3G 0.032 0.006 -10000 0 -0.068 1 1
RASGRP2 0.004 0.016 -10000 0 -0.14 5 5
RASGRP1 -0.045 0.086 0.22 12 -0.24 23 35
HLA-A 0.032 0.006 -10000 0 -0.063 1 1
RASSF5 0 0 -10000 0 -10000 0 0
RAP1A/GTP/RAPL 0.022 0.003 -10000 0 0 9 9
mol:GTP 0 0 -10000 0 -10000 0 0
mol:GDP -0.003 0.042 0.15 17 -0.095 10 27
PDK1/CARD11/BCL10/MALT1/TRAF6 -0.006 0.027 -10000 0 -0.11 13 13
PRKCA -0.012 0.039 0.18 4 -0.16 5 9
GRAP2 0.03 0.008 -10000 0 -10000 0 0
mol:IP3 0.005 0.043 -10000 0 -0.2 8 8
EntrezGene:6957 0 0.001 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8 0.01 0.036 -10000 0 -0.23 6 6
ORAI1 -0.33 0.5 -10000 0 -1.1 155 155
CSK 0.008 0.048 0.19 5 -0.27 7 12
B7 family/CD28 0.05 0.058 0.22 4 -0.27 5 9
CHUK 0.024 0.015 -10000 0 -0.063 1 1
TCR/CD3/MHC I/CD8/LCK/ZAP-70 0.012 0.048 0.13 2 -0.28 8 10
PTPN6 0.004 0.047 0.17 10 -0.25 8 18
VAV1 0.011 0.056 0.19 16 -0.28 7 23
Monovalent TCR/CD3 0.014 0.029 -10000 0 -0.22 6 6
CBL 0.032 0.004 -10000 0 -10000 0 0
LCK 0.005 0.052 0.17 11 -0.25 7 18
PAG1 0.01 0.046 0.17 4 -0.25 8 12
RAP1A 0.032 0.004 -10000 0 0 9 9
TCR/CD3/MHC I/CD8/LCK 0.011 0.048 0.13 3 -0.27 8 11
CD80 0.032 0.007 -10000 0 -0.005 13 13
CD86 0.027 0.021 -10000 0 -0.041 37 37
PDK1/CARD11/BCL10/MALT1 0.002 0.033 -10000 0 -0.12 13 13
HRAS 0.031 0.007 -10000 0 -10000 0 0
GO:0035030 -0.001 0.041 0.16 5 -0.24 5 10
CD8A 0 0.001 -10000 0 -10000 0 0
CD8B 0.032 0.007 -10000 0 -0.064 2 2
PTPRC 0.009 0.041 -10000 0 -0.063 121 121
PDK1/PKC theta -0.003 0.069 0.25 11 -0.27 7 18
CSK/PAG1 0.006 0.044 0.16 2 -0.26 7 9
SOS1 0 0 -10000 0 -10000 0 0
peptide-MHC class I 0.046 0.011 -10000 0 -0.05 1 1
GRAP2/SLP76 0.034 0.057 0.2 4 -0.27 7 11
STIM1 -0.065 0.12 1.1 2 -10000 0 2
RAS family/GTP -0.007 0.049 0.16 10 -0.15 20 30
TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin 0.014 0.052 -10000 0 -0.38 6 6
mol:DAG -0.021 0.026 -10000 0 -0.18 9 9
RAP1A/GDP 0 0.021 0.063 15 -0.046 9 24
PLCG1 0.03 0.009 -10000 0 -10000 0 0
CD247 0.032 0.008 -10000 0 -0.068 2 2
cytotoxic T cell degranulation -0.12 0.26 -10000 0 -0.58 126 126
RAP1A/GTP 0.003 0.007 -10000 0 -0.056 4 4
mol:PI-3-4-5-P3 0.004 0.06 0.2 10 -0.23 11 21
LAT/GRAP2/SLP76/VAV1/PLCgamma1 0.012 0.053 -10000 0 -0.25 7 7
NRAS 0.009 0.041 -10000 0 -0.063 125 125
ZAP70 0.032 0.003 -10000 0 -10000 0 0
GRB2/SOS1 0.023 0.004 -10000 0 -10000 0 0
LAT/GRAP2/SLP76/VAV1 0.011 0.052 0.19 8 -0.26 6 14
MALT1 0.028 0.02 -10000 0 -0.063 21 21
TRAF6 0.032 0.005 -10000 0 -10000 0 0
CD8 heterodimer 0.023 0.008 -10000 0 -0.022 13 13
CARD11 0 0 -10000 0 -10000 0 0
PRKCB -0.016 0.02 -10000 0 -0.13 9 9
PRKCE -0.011 0.039 0.18 4 -0.16 5 9
PRKCQ 0 0.068 0.23 13 -0.26 10 23
LCP2 0.026 0.022 -10000 0 -0.063 29 29
BCL10 0.031 0.009 -10000 0 -0.011 17 17
regulation of survival gene product expression 0.001 0.056 0.18 10 -0.2 11 21
IKK complex -0.006 0.036 0.19 7 -0.085 5 12
RAS family/GDP -0.006 0.01 -10000 0 -0.031 10 10
MAP3K14 -0.003 0.038 0.13 5 -0.16 11 16
PDPK1 -0.001 0.056 0.19 11 -0.21 9 20
TCR/CD3/MHC I/CD8/Fyn 0.014 0.055 0.25 1 -0.36 6 7
E-cadherin signaling in the nascent adherens junction

Figure S66.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S66.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CTTN 0.007 0.053 -10000 0 -0.3 14 14
KLHL20 0.028 0.068 0.17 32 -0.19 12 44
CYFIP2 0.018 0.016 -10000 0 -10000 0 0
Rac1/GDP 0.005 0.039 0.17 10 -0.16 10 20
ENAH 0.005 0.055 -10000 0 -0.3 15 15
AP1M1 0 0 -10000 0 -10000 0 0
RAP1B 0 0 -10000 0 -10000 0 0
RAP1A 0.032 0.004 -10000 0 0 9 9
CTNNB1 0.032 0.005 -10000 0 -10000 0 0
CDC42/GTP -0.028 0.033 0.11 20 -0.12 7 27
ABI1/Sra1/Nap1 -0.01 0.022 -10000 0 -0.12 14 14
E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.072 0.035 -10000 0 -0.062 2 2
RAPGEF1 -0.003 0.059 0.16 30 -0.28 11 41
CTNND1 0.03 0.014 -10000 0 -0.063 10 10
regulation of calcium-dependent cell-cell adhesion 0.02 0.056 -10000 0 -0.3 14 14
CRK 0.005 0.061 0.17 25 -0.29 13 38
E-cadherin/gamma catenin/alpha catenin 0.058 0.029 -10000 0 -0.046 35 35
alphaE/beta7 Integrin 0.046 0.012 -10000 0 -0.05 2 2
IQGAP1 0.01 0.04 -10000 0 -0.063 120 120
NCKAP1 0.032 0.002 -10000 0 -10000 0 0
Rap1/GTP/I-afadin 0.036 0.018 -10000 0 -0.024 40 40
DLG1 0.006 0.055 -10000 0 -0.29 15 15
ChemicalAbstracts:7440-70-2 0 0 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 -0.03 0.018 -10000 0 -0.089 15 15
MLLT4 0.03 0.008 -10000 0 -10000 0 0
ARF6/GTP/NME1/Tiam1 0.036 0.018 -10000 0 -0.024 30 30
PI3K -0.036 0.022 -10000 0 -0.12 12 12
ARF6 0.031 0.008 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
E-cadherin/gamma catenin 0.043 0.021 -10000 0 -0.057 19 19
TIAM1 0.031 0.008 -10000 0 -10000 0 0
E-cadherin(dimer)/Ca2+ 0.066 0.034 -10000 0 -10000 0 0
AKT1 -0.016 0.036 0.14 9 -0.1 2 11
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
CDH1 0.03 0.013 -10000 0 -0.063 8 8
RhoA/GDP 0.012 0.061 0.18 28 -0.17 16 44
actin cytoskeleton organization 0.023 0.054 0.14 32 -0.14 12 44
CDC42/GDP 0.011 0.057 0.17 27 -0.17 16 43
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.011 0.026 -10000 0 -0.11 19 19
ITGB7 0.032 0.008 -10000 0 -0.063 2 2
RAC1 0.023 0.015 -10000 0 -10000 0 0
E-cadherin/beta catenin/alpha catenin/p120 catenin 0.072 0.036 -10000 0 -10000 0 0
E-cadherin/Ca2+/beta catenin/alpha catenin 0.052 0.022 -10000 0 -0.032 28 28
mol:GDP -0.002 0.063 0.18 29 -0.18 16 45
CDC42/GTP/IQGAP1 0.023 0.035 -10000 0 -0.04 118 118
JUP 0.029 0.017 -10000 0 -0.063 16 16
p120 catenin/RhoA/GDP 0.025 0.064 0.19 28 -0.17 17 45
RAC1/GTP/IQGAP1 0.016 0.032 -10000 0 -0.04 89 89
PIP5K1C/AP1M1 0.022 0.006 -10000 0 0 36 36
RHOA 0.032 0.006 -10000 0 -10000 0 0
CDC42 0.031 0.006 -10000 0 -10000 0 0
CTNNA1 0.032 0.004 -10000 0 -10000 0 0
positive regulation of S phase of mitotic cell cycle 0.015 0.041 0.11 29 -0.095 14 43
NME1 0 0 -10000 0 0 2 2
clathrin coat assembly 0 0 -10000 0 -10000 0 0
TJP1 0.006 0.055 -10000 0 -0.3 15 15
regulation of cell-cell adhesion -0.03 0.017 0.043 1 -0.1 13 14
WASF2 -0.006 0.012 -10000 0 -0.067 14 14
Rap1/GTP -0.022 0.045 0.14 29 -0.14 4 33
E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.082 0.043 -10000 0 -0.089 1 1
CCND1 0.017 0.047 0.13 28 -0.12 14 42
VAV2 0.013 0.11 -10000 0 -0.58 13 13
RAP1/GDP -0.011 0.052 0.16 31 -0.17 3 34
adherens junction assembly 0.006 0.053 -10000 0 -0.29 15 15
homophilic cell adhesion 0 0 -10000 0 -10000 0 0
ABI1 0.025 0.014 -10000 0 -10000 0 0
PIP5K1C 0.03 0.008 -10000 0 -10000 0 0
regulation of heterotypic cell-cell adhesion 0.054 0.038 0.19 2 -0.091 1 3
E-cadherin/beta catenin 0.005 0.022 -10000 0 -0.14 7 7
mol:GTP 0 0 -10000 0 0 2 2
SRC 0.005 0.053 -10000 0 -0.3 14 14
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
Rac1/GTP -0.007 0.055 -10000 0 -0.29 13 13
E-cadherin/beta catenin/alpha catenin 0.059 0.025 -10000 0 -0.04 28 28
ITGAE 0.032 0.005 -10000 0 -10000 0 0
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.02 0.057 -10000 0 -0.3 14 14
S1P3 pathway

Figure S67.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S67.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB 0.032 0.007 -10000 0 -0.063 2 2
mol:S1P 0 0 -10000 0 -10000 0 0
S1P1/S1P/Gi -0.018 0.026 -10000 0 -0.075 30 30
GNAO1 0.003 0.009 -10000 0 -10000 0 0
S1P/S1P3/G12/G13 0.03 0.02 -10000 0 -0.023 2 2
AKT1 -0.008 0.069 -10000 0 -0.43 13 13
AKT3 -0.008 0.046 -10000 0 -0.27 9 9
mol:GTP 0 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB 0.032 0.007 -10000 0 -0.063 2 2
GNAI2 0.032 0.006 -10000 0 -0.028 1 1
GNAI3 0.022 0.03 -10000 0 -0.062 58 58
GNAI1 0.02 0.017 -10000 0 -0.062 1 1
mol:GDP 0 0 -10000 0 -10000 0 0
S1PR3 0.001 0 -10000 0 -0.009 1 1
S1PR2 0 0 -10000 0 -10000 0 0
EDG1 0 0 -10000 0 -10000 0 0
mol:Ca2+ 0.002 0.013 -10000 0 -0.12 1 1
MAPK3 0.001 0.013 -10000 0 -0.14 2 2
MAPK1 0.001 0.01 -10000 0 -10000 0 0
JAK2 -0.009 0.036 -10000 0 -0.16 19 19
CXCR4 0 0.009 -10000 0 -0.12 1 1
FLT1 0.031 0.009 -10000 0 -0.028 1 1
RhoA/GDP 0.023 0.004 -10000 0 0 15 15
Rac1/GDP 0.017 0.011 -10000 0 -10000 0 0
SRC 0.001 0.013 -10000 0 -0.14 2 2
S1P/S1P3/Gi 0.002 0.013 -10000 0 -0.12 1 1
RAC1 0.023 0.015 -10000 0 -10000 0 0
RhoA/GTP -0.031 0.041 -10000 0 -0.14 24 24
VEGFA -0.019 0.047 -10000 0 -0.062 275 275
S1P/S1P2/Gi 0.002 0.013 0.085 6 -0.11 2 8
VEGFR1 homodimer/VEGFA homodimer -0.003 0.048 -10000 0 -0.049 254 254
RHOA 0.032 0.006 -10000 0 -10000 0 0
S1P/S1P3/Gq 0.017 0.009 -10000 0 -0.1 1 1
GNAQ 0.031 0.006 -10000 0 -10000 0 0
GNAZ 0.027 0.013 -10000 0 -10000 0 0
G12/G13 0.034 0.022 -10000 0 -10000 0 0
GNA14 0.031 0.009 -10000 0 -0.063 2 2
GNA15 0.03 0.013 -10000 0 -0.016 27 27
GNA12 0.023 0.015 -10000 0 -10000 0 0
GNA13 0.032 0.007 -10000 0 -0.063 2 2
GNA11 0.031 0.006 -10000 0 -10000 0 0
Rac1/GTP -0.027 0.037 -10000 0 -0.13 17 17
mTOR signaling pathway

Figure S68.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S68.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GBL 0 0 -10000 0 -10000 0 0
MKNK1 0.032 0.005 -10000 0 -10000 0 0
mol:PIP3 -0.008 0.014 -10000 0 -10000 0 0
FRAP1 0.04 0.06 0.22 5 -0.44 2 7
AKT1 0.033 0.08 0.16 123 -0.13 9 132
INSR 0.032 0.006 -10000 0 -10000 0 0
Insulin Receptor/Insulin 0.041 0.011 -10000 0 -10000 0 0
mol:GTP 0.036 0.088 0.18 125 -0.14 1 126
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA/eIF3/40s Ribosomal subunit 0.009 0.023 -10000 0 -0.17 2 2
TSC2 0.032 0.004 -10000 0 -10000 0 0
RHEB/GDP -0.007 0.042 0.11 41 -0.13 5 46
TSC1 0.031 0.008 -10000 0 -10000 0 0
Insulin Receptor/IRS1 0.03 0.009 -10000 0 -10000 0 0
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA 0.043 0.042 0.14 5 -0.18 2 7
mol:GDP 0 0 -10000 0 -10000 0 0
EIF3A 0.024 0.015 -10000 0 -10000 0 0
RPS6KB1 0.05 0.07 0.2 32 -0.25 2 34
MAP3K5 -0.012 0.056 0.16 2 -0.2 40 42
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
apoptosis -0.012 0.056 0.16 2 -0.2 40 42
mol:LY294002 0 0 0.001 1 -0.001 1 2
EIF4B 0.044 0.069 0.19 39 -0.23 2 41
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 0.036 0.045 0.23 4 -0.23 1 5
eIF4E/eIF4G1/eIF4A1 0.025 0.032 -10000 0 -0.24 3 3
KIAA1303 0 0 -10000 0 -10000 0 0
PI3K 0.046 0.026 0.15 1 -10000 0 1
mTOR/RHEB/GTP/Raptor/GBL 0.009 0.046 0.12 57 -10000 0 57
FKBP1A 0.03 0.009 -10000 0 -0.063 1 1
RHEB/GTP 0.034 0.051 0.15 52 -0.13 5 57
mol:Amino Acids 0 0 0.001 1 -0.001 1 2
FKBP12/Rapamycin 0.023 0.007 -10000 0 -0.04 1 1
PDPK1 -0.013 0.021 0.16 5 -10000 0 5
EIF4E 0.031 0.009 -10000 0 -0.063 4 4
ASK1/PP5C 0.013 0.16 -10000 0 -0.52 42 42
mTOR/RHEB/GTP/Raptor/GBL/eIF4E 0.016 0.031 -10000 0 -0.24 4 4
TSC1/TSC2 0.041 0.096 0.19 126 -0.15 1 127
tumor necrosis factor receptor activity 0 0 0.001 1 -0.001 1 2
RPS6 0.028 0.011 -10000 0 -10000 0 0
PPP5C 0.031 0.007 -10000 0 -10000 0 0
EIF4G1 0.031 0.006 -10000 0 -10000 0 0
IRS1 0.01 0.007 -10000 0 -10000 0 0
INS 0.031 0.006 -10000 0 -10000 0 0
PTEN 0.023 0.016 -10000 0 -0.062 2 2
PDK2 -0.013 0.021 0.16 5 -10000 0 5
EIF4EBP1 -0.033 0.094 -10000 0 -0.97 3 3
PIK3CA 0.029 0.018 -10000 0 -0.063 17 17
PPP2R5D 0.033 0.058 0.22 6 -0.4 2 8
peptide biosynthetic process -0.022 0.016 0.18 3 -10000 0 3
RHEB 0.022 0.015 -10000 0 -10000 0 0
EIF4A1 0.03 0.014 -10000 0 -0.063 10 10
mol:Rapamycin 0 0.001 0.002 104 -0.003 1 105
EEF2 -0.022 0.016 0.18 3 -10000 0 3
eIF4E/4E-BP1 -0.023 0.094 -10000 0 -0.91 3 3
Signaling events mediated by HDAC Class III

Figure S69.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S69.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EP300 0.03 0.008 -10000 0 -10000 0 0
HDAC4 0.032 0.003 -10000 0 -10000 0 0
induction of apoptosis 0 0 -10000 0 -10000 0 0
regulation of S phase of mitotic cell cycle 0.007 0.011 -10000 0 -10000 0 0
CDKN1A 0 0.04 0.065 118 -0.073 45 163
KAT2B 0 0 -10000 0 -10000 0 0
BAX 0.03 0.013 -10000 0 -0.063 6 6
FOXO3 0 0.012 0.027 76 -10000 0 76
FOXO1 0.028 0.016 -10000 0 -0.063 11 11
FOXO4 0.011 0.003 -10000 0 -10000 0 0
response to UV 0 0 -10000 0 -10000 0 0
XRCC6 0.03 0.009 -10000 0 -10000 0 0
TAT 0.032 0.005 -10000 0 0 12 12
mol:Lysophosphatidic acid 0 0 -10000 0 -10000 0 0
MYOD1 -0.011 0.002 -10000 0 -10000 0 0
PPARGC1A 0.032 0.008 -10000 0 -0.063 3 3
FHL2 0.03 0.01 -10000 0 -0.063 3 3
response to nutrient levels 0 0 -10000 0 -10000 0 0
KU70/SIRT1 0.037 0.022 -10000 0 -10000 0 0
HIST2H4A -0.007 0.011 -10000 0 -10000 0 0
SIRT1/FOXO3a 0.019 0.019 0.15 4 -10000 0 4
SIRT1 0.026 0.016 -10000 0 -10000 0 0
response to hypoxia 0 0 -10000 0 -10000 0 0
SIRT1/MEF2D/HDAC4 0.041 0.044 -10000 0 -0.039 2 2
SIRT1/Histone H1b 0.023 0.026 -10000 0 -0.14 8 8
apoptosis -0.037 0.047 0.04 125 -10000 0 125
SIRT1/PGC1A 0.033 0.021 -10000 0 -0.041 3 3
p53/SIRT1 0.032 0.034 0.1 37 -0.055 30 67
SIRT1/FOXO4 0.024 0.022 -10000 0 -0.12 6 6
FOXO1/FHL2/SIRT1 0.035 0.044 -10000 0 -0.043 31 31
HIST1H1E 0.011 0.004 -10000 0 -0.028 1 1
SIRT1/p300 0.037 0.022 -10000 0 -10000 0 0
muscle cell differentiation 0.01 0.016 -10000 0 -10000 0 0
TP53 0.02 0.033 -10000 0 -0.061 65 65
KU70/SIRT1/BAX 0.038 0.047 -10000 0 -0.04 125 125
CREBBP 0.032 0.004 -10000 0 -10000 0 0
MEF2D 0.032 0.005 -10000 0 -10000 0 0
HIV-1 Tat/SIRT1 0.037 0.022 -10000 0 -10000 0 0
ACSS2 -0.007 0.011 -10000 0 -10000 0 0
SIRT1/PCAF/MYOD -0.01 0.016 -10000 0 -10000 0 0
Role of Calcineurin-dependent NFAT signaling in lymphocytes

Figure S70.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S70.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.03 0.008 -10000 0 0 34 34
NFATC1 0.018 0.051 0.23 3 -0.24 10 13
NFATC2 -0.036 0.079 0.16 2 -0.17 117 119
NFATC3 0.009 0.004 -10000 0 -10000 0 0
YWHAE 0.032 0.005 -10000 0 -10000 0 0
Calcineurin A alpha-beta B1/CABIN1 -0.023 0.076 0.15 3 -0.23 42 45
Exportin 1/Ran/NUP214 0.061 0.019 -10000 0 -0.036 12 12
mol:DAG 0 0 -10000 0 -10000 0 0
CABIN1/MEF2D/CaM/Ca2+/CAMK IV 0.009 0.089 0.15 2 -0.22 40 42
BCL2/BAX 0.043 0.017 -10000 0 -0.05 6 6
CaM/Ca2+/Calcineurin A alpha-beta B1 0.021 0.008 -10000 0 -10000 0 0
CaM/Ca2+ 0.021 0.008 -10000 0 -10000 0 0
BAX 0.03 0.013 -10000 0 -0.063 6 6
MAPK14 0.032 0.005 -10000 0 -0.063 1 1
BAD 0.032 0.004 -10000 0 -10000 0 0
CABIN1/MEF2D -0.008 0.081 0.15 2 -0.22 40 42
Calcineurin A alpha-beta B1/BCL2 0.031 0.006 -10000 0 0 17 17
FKBP8 0.031 0.006 -10000 0 -10000 0 0
activation-induced cell death of T cells 0.008 0.08 0.22 40 -0.15 2 42
KPNB1 0.032 0.003 -10000 0 -10000 0 0
KPNA2 0.03 0.014 -10000 0 -0.063 11 11
XPO1 0.033 0.001 -10000 0 -10000 0 0
SFN 0.026 0.023 -10000 0 -0.063 31 31
MAP3K8 0.018 0.026 -10000 0 -0.063 37 37
NFAT4/CK1 alpha 0.022 0.03 -10000 0 -0.079 37 37
MEF2D/NFAT1/Cbp/p300 0.009 0.1 -10000 0 -0.17 110 110
CABIN1 -0.023 0.076 0.15 3 -0.23 41 44
CALM1 0.029 0.01 -10000 0 -10000 0 0
RAN 0.032 0.004 -10000 0 -10000 0 0
MAP3K1 0.032 0.006 -10000 0 -0.063 1 1
CAMK4 0.032 0.004 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
MAPK3 0.032 0.002 -10000 0 -10000 0 0
YWHAH 0.015 0.016 -10000 0 0 279 279
Calcineurin A alpha-beta B1/AKAP79/PKA 0.044 0.015 -10000 0 -10000 0 0
YWHAB 0.03 0.009 -10000 0 -10000 0 0
MAPK8 0.025 0.014 -10000 0 -10000 0 0
MAPK9 0.032 0.005 -10000 0 -10000 0 0
YWHAG 0 0 -10000 0 -10000 0 0
FKBP1A 0.03 0.009 -10000 0 -0.063 1 1
NFAT1-c-4/YWHAQ 0.007 0.072 0.26 1 -0.23 21 22
PRKCH 0.03 0.01 -10000 0 -0.063 2 2
CABIN1/Cbp/p300 0.044 0.014 -10000 0 -10000 0 0
CASP3 0.014 0.037 -10000 0 -0.063 94 94
PIM1 0.032 0.005 -10000 0 -0.063 1 1
Calcineurin A alpha-beta B1/FKBP12/FK506 0.02 0.006 -10000 0 -0.031 1 1
apoptosis 0.017 0.024 -10000 0 -0.097 17 17
14-3-3 family/BAD/CaM/Ca2+/Calcineurin A alpha-beta B1 0.001 0.036 -10000 0 -0.19 11 11
PRKCB 0 0 -10000 0 -10000 0 0
PRKCE 0.032 0.002 -10000 0 -10000 0 0
JNK2/NFAT4 0.022 0.03 0.099 1 -0.16 6 7
BAD/BCL-XL 0.044 0.013 -10000 0 -10000 0 0
PRKCD 0.032 0.006 -10000 0 -10000 0 0
NUP214 0.031 0.007 -10000 0 0 22 22
PRKCZ 0 0 -10000 0 -10000 0 0
PRKCA 0.032 0.004 -10000 0 -10000 0 0
PRKCG 0.031 0.008 -10000 0 -10000 0 0
PRKCQ 0.024 0.014 -10000 0 -10000 0 0
FKBP38/BCL2 0.045 0.012 -10000 0 -10000 0 0
EP300 0.03 0.008 -10000 0 -10000 0 0
PRKCB1 0 0 -10000 0 -10000 0 0
CSNK2A1 0.03 0.008 -10000 0 -10000 0 0
NFATc/JNK1 0.026 0.049 0.27 1 -0.24 10 11
CaM/Ca2+/FKBP38 0.037 0.016 -10000 0 -10000 0 0
FKBP12/FK506 0.022 0.007 -10000 0 -0.039 1 1
CSNK1A1 -0.016 0.006 -10000 0 -10000 0 0
CaM/Ca2+/CAMK IV 0.038 0.015 -10000 0 -10000 0 0
NFATc/ERK1 0.035 0.054 0.23 2 -0.23 10 12
CABIN1/YWHAQ/CaM/Ca2+/CAMK IV 0.008 0.09 0.15 2 -0.22 40 42
NR4A1 -0.046 0.066 0.14 7 -0.16 104 111
GSK3B 0.032 0.006 -10000 0 -10000 0 0
positive T cell selection 0.009 0.004 -10000 0 -10000 0 0
NFAT1/CK1 alpha -0.024 0.059 0.086 4 -0.12 114 118
RCH1/ KPNB1 0.046 0.015 -10000 0 -0.05 11 11
YWHAQ 0.032 0.004 -10000 0 -10000 0 0
PRKACA 0.031 0.006 -10000 0 0 17 17
AKAP5 0.03 0.008 -10000 0 -10000 0 0
MEF2D 0.032 0.005 -10000 0 -10000 0 0
mol:FK506 0 0 -10000 0 -10000 0 0
YWHAZ 0.032 0.006 -10000 0 -10000 0 0
NFATc/p38 alpha 0.035 0.055 0.24 3 -0.24 10 13
CREBBP 0.032 0.004 -10000 0 -10000 0 0
BCL2 0.032 0.006 -10000 0 0 17 17
Regulation of Telomerase

Figure S71.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S71.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Telomerase catalytic core complex 0.021 0.087 0.3 2 -0.38 8 10
RAD9A 0.032 0.006 -10000 0 -0.063 1 1
AP1 0.021 0.041 -10000 0 -0.05 117 117
IFNAR2 0.032 0.005 -10000 0 -10000 0 0
AKT1 0.016 0.016 -10000 0 -0.054 20 20
ER alpha/Oestrogen 0.023 0.006 -10000 0 -10000 0 0
NFX1/SIN3/HDAC complex -0.004 0.051 -10000 0 -0.14 46 46
EGF 0.032 0.007 -10000 0 -0.062 2 2
SMG5 0.032 0.005 -10000 0 -10000 0 0
SMG6 0.032 0.005 -10000 0 -10000 0 0
SP3/HDAC2 0.032 0.035 -10000 0 -0.052 65 65
TERT/c-Abl 0.033 0.088 0.24 1 -0.35 9 10
SAP18 0.031 0.008 -10000 0 -10000 0 0
MRN complex 0.062 0.019 -10000 0 -0.044 1 1
WT1 0.031 0.011 -10000 0 -0.064 5 5
WRN 0.031 0.009 -10000 0 -0.063 4 4
SP1 0.032 0.005 -10000 0 -10000 0 0
SP3 0.019 0.034 -10000 0 -0.063 74 74
TERF2IP 0.029 0.01 -10000 0 -10000 0 0
Telomerase/Nucleolin 0.046 0.097 -10000 0 -0.34 10 10
Mad/Max 0.045 0.013 -10000 0 -10000 0 0
TERT 0.021 0.088 0.3 2 -0.39 8 10
CCND1 0.011 0.089 0.32 1 -0.38 8 9
MAX 0.03 0.008 -10000 0 -10000 0 0
RBBP7 0.032 0.002 -10000 0 -10000 0 0
RBBP4 0.015 0.036 -10000 0 -0.063 89 89
TERF2 -0.02 0.02 0.047 30 -10000 0 30
PTGES3 0.031 0.007 -10000 0 -10000 0 0
SIN3A 0 0 -10000 0 -10000 0 0
Telomerase/911 0.043 0.062 -10000 0 -0.34 6 6
CDKN1B -0.025 0.011 -10000 0 -0.057 1 1
RAD1 0.032 0.007 -10000 0 -0.063 2 2
XRCC5 0.032 0.002 -10000 0 -10000 0 0
XRCC6 0.03 0.009 -10000 0 -10000 0 0
SAP30 0.032 0.006 -10000 0 -10000 0 0
TRF2/PARP2 0.038 0.018 -10000 0 -10000 0 0
UBE3A 0.032 0.005 -10000 0 -10000 0 0
JUN 0.032 0.005 -10000 0 -10000 0 0
E6 0 0.001 -10000 0 -10000 0 0
HPV-16 E6/E6AP 0.024 0.004 -10000 0 -10000 0 0
FOS 0.008 0.04 -10000 0 -0.063 120 120
IFN-gamma/IRF1 0.037 0.035 -10000 0 -0.05 62 62
PARP2 0.031 0.008 -10000 0 -10000 0 0
BLM 0.01 0.04 -10000 0 -0.063 119 119
Telomerase 0.006 0.065 -10000 0 -0.24 31 31
IRF1 0.021 0.033 -10000 0 -0.063 66 66
ESR1 0.031 0.008 -10000 0 -10000 0 0
KU/TER 0.045 0.013 -10000 0 -10000 0 0
ATM/TRF2 0.036 0.029 -10000 0 -0.06 30 30
ubiquitin-dependent protein catabolic process -0.003 0.053 -10000 0 -0.16 35 35
HPV-16 E6/E6AP/NFX1/SIN3/HDAC complex -0.002 0.053 -10000 0 -0.16 34 34
HDAC1 0.02 0.031 -10000 0 -0.063 61 61
HDAC2 0.03 0.012 -10000 0 -0.065 4 4
ATM 0.012 0.017 0.091 6 -0.053 25 31
SMAD3 -0.023 0.008 -10000 0 -0.049 26 26
ABL1 0.031 0.008 -10000 0 -0.063 1 1
MXD1 0.033 0.002 -10000 0 -10000 0 0
MRE11A 0.032 0.005 -10000 0 -10000 0 0
HUS1 0.023 0.015 -10000 0 -10000 0 0
RPS6KB1 0.032 0.006 -10000 0 -0.063 1 1
TERT/NF kappa B1/14-3-3 0.042 0.11 0.29 1 -0.38 16 17
NR2F2 0.031 0.009 -10000 0 -0.06 4 4
MAPK3 -0.022 0.004 -10000 0 -10000 0 0
MAPK1 -0.02 0.007 -10000 0 -10000 0 0
TGFB1/TGF beta receptor Type II 0.026 0.022 -10000 0 -0.062 26 26
NFKB1 0.031 0.009 -10000 0 -0.063 4 4
HNRNPC 0.031 0.008 -10000 0 0 29 29
DNA damage response signal transduction by p53 class mediator resulting in induction of apoptosis 0.012 0.017 0.091 6 -0.053 25 31
NBN 0.032 0.004 -10000 0 -10000 0 0
EGFR 0.012 0.018 -10000 0 -0.063 6 6
mol:Oestrogen 0 0.001 -10000 0 -10000 0 0
EGF/EGFR 0.018 0.025 -10000 0 -0.05 8 8
MYC 0.009 0.04 -10000 0 -0.063 119 119
IL2 0.032 0.005 -10000 0 -10000 0 0
KU 0.045 0.013 -10000 0 -10000 0 0
RAD50 0.032 0.004 -10000 0 -10000 0 0
HSP90AA1 0.03 0.008 -10000 0 -10000 0 0
TGFB1 0.026 0.022 -10000 0 -0.063 26 26
TRF2/BLM 0.018 0.041 -10000 0 -0.053 114 114
FRAP1 0 0 -10000 0 -10000 0 0
KU/TERT 0.042 0.097 0.26 1 -0.35 10 11
SP1/HDAC2 0.043 0.017 -10000 0 -0.053 4 4
PINX1 0 0 -10000 0 -10000 0 0
Telomerase/EST1A 0.046 0.098 -10000 0 -0.34 10 10
Smad3/Myc 0.007 0.035 -10000 0 -0.05 137 137
911 complex 0.045 0.032 -10000 0 -0.046 4 4
IFNG 0.032 0.008 -10000 0 -10000 0 0
Telomerase/PinX1 0.035 0.09 -10000 0 -0.33 10 10
Telomerase/AKT1/mTOR/p70S6K 0.009 0.094 0.18 2 -0.29 37 39
SIN3B 0.031 0.006 -10000 0 -10000 0 0
YWHAE 0.032 0.005 -10000 0 -10000 0 0
Telomerase/EST1B 0.047 0.096 -10000 0 -0.35 9 9
response to DNA damage stimulus 0.003 0.014 -10000 0 -0.1 6 6
MRN complex/TRF2/Rap1 0.075 0.039 -10000 0 -10000 0 0
TRF2/WRN 0.04 0.018 -10000 0 -0.052 4 4
Telomerase/hnRNP C1/C2 0.045 0.098 -10000 0 -0.33 11 11
E2F1 0.03 0.008 -10000 0 -10000 0 0
ZNFX1 0 0 -10000 0 -10000 0 0
PIF1 0 0 -10000 0 -10000 0 0
NCL 0.032 0.002 -10000 0 -10000 0 0
DKC1 0.031 0.011 -10000 0 -0.063 7 7
telomeric DNA binding 0 0 -10000 0 -10000 0 0
BCR signaling pathway

Figure S72.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S72.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
JUN 0.011 0.08 0.3 7 -0.26 11 18
IKBKB 0.017 0.059 0.29 5 -0.25 7 12
AKT1 0.013 0.077 0.24 31 -10000 0 31
IKBKG 0.012 0.05 0.27 4 -0.22 7 11
CALM1 -0.009 0.047 0.2 2 -0.18 13 15
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
MAP3K1 0.034 0.094 0.29 17 -0.39 7 24
MAP3K7 0.031 0.008 -10000 0 -0.063 1 1
mol:Ca2+ -0.006 0.053 0.21 1 -0.18 17 18
DOK1 0.032 0.002 -10000 0 -10000 0 0
AP-1 -0.006 0.062 0.23 6 -0.19 10 16
LYN 0.021 0.031 -10000 0 -0.063 60 60
BLNK 0.013 0.031 -10000 0 -0.063 59 59
SHC1 0.024 0.026 -10000 0 -0.063 40 40
BCR complex 0.045 0.014 -10000 0 -0.063 2 2
CD22 -0.007 0.03 -10000 0 -0.24 2 2
CAMK2G 0 0.032 0.23 3 -0.2 5 8
CSNK2A1 0.03 0.008 -10000 0 -10000 0 0
INPP5D 0 0 -10000 0 -10000 0 0
SHC/GRB2/SOS1 -0.048 0.02 -10000 0 -0.096 25 25
GO:0007205 -0.007 0.053 0.21 1 -0.18 17 18
SYK 0.025 0.024 -10000 0 -0.063 34 34
ELK1 -0.013 0.053 0.18 2 -0.18 17 19
NFATC1 -0.015 0.064 0.27 8 -0.24 13 21
B-cell antigen/BCR complex 0.045 0.014 -10000 0 -0.063 2 2
PAG1/CSK 0.024 0.003 -10000 0 -10000 0 0
NFKBIB 0.021 0.033 0.16 4 -0.13 14 18
HRAS -0.013 0.053 0.18 6 -0.18 15 21
NFKBIA 0.021 0.033 0.16 4 -0.12 14 18
NF-kappa-B/RelA/I kappa B beta 0.024 0.03 0.15 5 -0.096 14 19
RasGAP/Csk 0.051 0.066 -10000 0 -0.09 2 2
mol:GDP -0.005 0.054 0.19 2 -0.18 17 19
PTEN 0.023 0.016 -10000 0 -0.063 2 2
CD79B 0.032 0.005 -10000 0 -0.062 1 1
NF-kappa-B/RelA/I kappa B alpha 0.024 0.029 0.15 5 -0.093 14 19
GRB2 0.032 0.006 -10000 0 -10000 0 0
PI3K/BCAP/CD19 -0.005 0.081 0.37 4 -0.3 4 8
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
mol:IP3 -0.006 0.053 0.22 1 -0.18 18 19
CSK 0.032 0.005 -10000 0 -10000 0 0
FOS -0.02 0.051 0.17 3 -0.19 13 16
CHUK -0.048 0.12 0.31 3 -0.25 120 123
IBTK 0.031 0.007 -10000 0 -10000 0 0
CARD11/BCL10/MALT1/TAK1 0.015 0.071 -10000 0 -0.18 15 15
PTPN6 -0.018 0.031 0.14 4 -0.23 2 6
RELA 0.032 0.004 -10000 0 -10000 0 0
BCL2A1 0.012 0.021 0.1 5 -0.069 14 19
VAV2 -0.011 0.055 0.16 3 -0.28 13 16
ubiquitin-dependent protein catabolic process 0.022 0.033 0.16 4 -0.12 14 18
BTK 0.016 0.011 -10000 0 -10000 0 0
CD19 -0.008 0.032 -10000 0 -0.24 2 2
MAP4K1 0.031 0.008 -10000 0 -0.063 1 1
CD72 0.03 0.009 -10000 0 -10000 0 0
PAG1 0 0 -10000 0 -10000 0 0
MAPK14 0.027 0.086 0.27 16 -0.34 7 23
SH3BP5 0.029 0.01 -10000 0 -10000 0 0
PIK3AP1 -0.007 0.051 -10000 0 -0.18 18 18
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 0.002 0.06 -10000 0 -0.29 14 14
RAF1 -0.017 0.052 0.19 6 -0.19 10 16
RasGAP/p62DOK/SHIP 0.042 0.057 -10000 0 -0.079 2 2
CD79A 0.031 0.009 -10000 0 -0.063 2 2
re-entry into mitotic cell cycle -0.006 0.061 0.25 5 -0.19 10 15
RASA1 0.032 0.006 -10000 0 -10000 0 0
MAPK3 -0.023 0.052 0.21 6 -0.21 5 11
MAPK1 -0.022 0.05 0.19 9 -0.18 7 16
CD72/SHP1 0.007 0.064 0.22 26 -0.31 1 27
NFKB1 0.031 0.009 -10000 0 -0.063 4 4
MAPK8 0.026 0.087 0.28 16 -0.34 7 23
actin cytoskeleton organization 0.031 0.088 0.2 41 -0.26 5 46
NF-kappa-B/RelA 0.047 0.057 0.27 5 -0.19 13 18
Calcineurin 0.009 0.065 0.2 1 -0.18 12 13
PI3K -0.025 0.049 -10000 0 -0.17 7 7
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 -0.001 0.043 -10000 0 -0.22 5 5
SOS1 0 0 -10000 0 -10000 0 0
Bam32/HPK1 0.036 0.079 -10000 0 -0.57 6 6
DAPP1 0.019 0.074 -10000 0 -0.64 5 5
cytokine secretion -0.014 0.062 0.26 8 -0.22 13 21
mol:DAG -0.006 0.053 0.22 1 -0.18 18 19
PLCG2 0.03 0.014 -10000 0 -0.063 10 10
MAP2K1 -0.021 0.05 0.18 7 -0.2 8 15
B-cell antigen/BCR complex/FcgammaRIIB 0.034 0.049 -10000 0 -0.049 119 119
mol:PI-3-4-5-P3 -0.02 0.05 0.21 10 -10000 0 10
ETS1 0.021 0.066 0.18 19 -0.23 2 21
B-cell antigen/BCR complex/LYN/SYK/BLNK 0.027 0.073 -10000 0 -0.09 18 18
B-cell antigen/BCR complex/LYN 0.006 0.036 -10000 0 -0.24 2 2
MALT1 0.028 0.02 -10000 0 -0.063 21 21
TRAF6 0.032 0.005 -10000 0 -10000 0 0
RAC1 0.028 0.085 0.19 46 -0.27 5 51
B-cell antigen/BCR complex/LYN/SYK 0.043 0.062 0.22 16 -0.3 1 17
CARD11 -0.007 0.052 0.19 2 -0.18 17 19
FCGR2B 0.01 0.04 -10000 0 -0.063 120 120
PPP3CA 0.026 0.013 -10000 0 -10000 0 0
BCL10 0.031 0.009 -10000 0 -0.063 3 3
IKK complex 0.003 0.039 0.16 9 -0.12 10 19
PTPRC 0.009 0.04 -10000 0 -0.063 121 121
PDPK1 -0.015 0.051 0.2 16 -10000 0 16
PPP3CB 0.024 0.014 -10000 0 -10000 0 0
PPP3CC 0.032 0.005 -10000 0 -10000 0 0
POU2F2 0.016 0.021 0.12 6 -0.069 10 16
Signaling events mediated by PRL

Figure S73.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S73.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CCNE1 0.03 0.011 -10000 0 -0.008 32 32
mol:Halofuginone 0.002 0.004 -10000 0 -0.037 4 4
ITGA1 0 0 -10000 0 -10000 0 0
CDKN1A 0.005 0.052 -10000 0 -0.34 10 10
PRL-3/alpha Tubulin 0.04 0.024 -10000 0 -0.05 28 28
mol:Ca2+ -0.023 0.021 0.053 27 -10000 0 27
AGT 0.029 0.01 -10000 0 -10000 0 0
CCNA2 -0.026 0.012 -10000 0 -0.071 5 5
TUBA1B 0.032 0.006 -10000 0 -10000 0 0
EGR1 0.008 0.008 -10000 0 -0.038 16 16
CDK2/Cyclin E1 0.035 0.062 -10000 0 -0.32 9 9
MAPK3 -0.023 0.008 -10000 0 -0.05 30 30
PRL-2 /Rab GGTase beta 0.047 0.009 -10000 0 -10000 0 0
MAPK1 -0.022 0.01 0 58 -0.05 30 88
PTP4A1 -0.017 0.007 -10000 0 -0.1 1 1
PTP4A3 0.026 0.023 -10000 0 -0.063 30 30
PTP4A2 0.032 0.006 -10000 0 -10000 0 0
ITGB1 -0.018 0.012 0 129 -0.05 23 152
SRC 0.031 0.008 -10000 0 -10000 0 0
RAC1 0.007 0.033 -10000 0 -0.33 4 4
Rab GGTase beta/Rab GGTase alpha 0.045 0.013 -10000 0 -10000 0 0
PRL-1/ATF-5 -0.014 0.043 0.18 22 -10000 0 22
RABGGTA 0.031 0.008 -10000 0 -10000 0 0
BCAR1 -0.015 0.016 0.049 30 -10000 0 30
RHOC -0.007 0.046 -10000 0 -0.34 6 6
RHOA 0.006 0.052 -10000 0 -0.33 11 11
cell motility 0.012 0.052 -10000 0 -0.29 5 5
PRL-1/alpha Tubulin -0.012 0.049 0.18 29 -10000 0 29
PRL-3/alpha1 Integrin 0.02 0.015 -10000 0 -0.039 30 30
ROCK1 0.012 0.05 -10000 0 -0.3 4 4
RABGGTB 0.032 0.005 -10000 0 0 11 11
CDK2 0.027 0.021 -10000 0 -0.063 24 24
mitosis -0.017 0.007 -10000 0 -0.1 1 1
ATF5 0.031 0.009 -10000 0 -0.063 1 1
Coregulation of Androgen receptor activity

Figure S74.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S74.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NRIP1 0.032 0.008 -9999 0 -0.062 2 2
SVIL 0.023 0.02 -9999 0 -0.062 14 14
ZNF318 0.031 0.003 -9999 0 -10000 0 0
JMJD2C 0.003 0 -9999 0 -10000 0 0
T-DHT/AR/Ubc9 0.044 0.016 -9999 0 -0.039 8 8
CARM1 0.031 0.006 -9999 0 -10000 0 0
PRDX1 0.032 0.005 -9999 0 -10000 0 0
PELP1 0.032 0.005 -9999 0 -10000 0 0
CTNNB1 0.032 0.005 -9999 0 -10000 0 0
AKT1 0.03 0.008 -9999 0 -10000 0 0
PTK2B 0.032 0.005 -9999 0 -10000 0 0
MED1 0.032 0.003 -9999 0 -10000 0 0
MAK 0.03 0.012 -9999 0 -0.064 7 7
response to oxidative stress 0 0 -9999 0 -10000 0 0
HIP1 0.017 0.025 -9999 0 -0.062 30 30
GSN 0.029 0.017 -9999 0 -0.062 15 15
NCOA2 0.032 0.004 -9999 0 -10000 0 0
NCOA6 0.031 0.008 -9999 0 -10000 0 0
DNA-PK 0.053 0.034 -9999 0 -0.051 22 22
NCOA4 0.025 0.014 -9999 0 -10000 0 0
PIAS3 0.032 0.004 -9999 0 -10000 0 0
cell proliferation 0.006 0.053 -9999 0 -0.42 7 7
XRCC5 0.032 0.002 -9999 0 -10000 0 0
UBE3A 0.033 0.005 -9999 0 -10000 0 0
T-DHT/AR/SNURF 0.024 0.01 -9999 0 -0.027 12 12
FHL2 0.012 0.028 -9999 0 -0.22 4 4
RANBP9 0.033 0.004 -9999 0 -10000 0 0
JMJD1A 0.006 0.002 -9999 0 -0.023 3 3
CDK6 0.022 0.015 -9999 0 -10000 0 0
TGFB1I1 -0.047 0.035 -9999 0 -0.062 424 424
T-DHT/AR/CyclinD1 0.031 0.034 -9999 0 -0.039 90 90
XRCC6 0.03 0.009 -9999 0 -10000 0 0
T-DHT/AR 0.039 0.03 -9999 0 -0.047 9 9
CTDSP1 0.032 0.007 -9999 0 -0.063 3 3
CTDSP2 0.027 0.011 -9999 0 -10000 0 0
BRCA1 0.032 0.01 -9999 0 -0.062 5 5
TCF4 0.031 0.007 -9999 0 -10000 0 0
CDKN2A 0.003 0.026 -9999 0 -0.063 52 52
SRF 0.033 0.01 -9999 0 -0.045 3 3
NKX3-1 0.006 0.016 -9999 0 -10000 0 0
KLK3 0.02 0.033 -9999 0 -10000 0 0
TMF1 0.031 0.01 -9999 0 -0.063 4 4
HNRNPA1 0.031 0.005 -9999 0 -10000 0 0
AOF2 0.001 0 -9999 0 -10000 0 0
APPL1 -0.021 0.007 -9999 0 -10000 0 0
T-DHT/AR/Caspase 8 0.043 0.019 -9999 0 -0.041 14 14
AR 0.031 0.014 -9999 0 -0.051 12 12
UBA3 0 0 -9999 0 -10000 0 0
PATZ1 0.03 0.008 -9999 0 -10000 0 0
PAWR 0.032 0.006 -9999 0 -10000 0 0
PRKDC 0.028 0.019 -9999 0 -0.063 21 21
PA2G4 0.031 0.007 -9999 0 -10000 0 0
UBE2I 0.032 0.003 -9999 0 -10000 0 0
T-DHT/AR/Cyclin D3/CDK11 p58 0.042 0.014 -9999 0 -0.035 8 8
RPS6KA3 0.033 0.005 -9999 0 -0.062 1 1
T-DHT/AR/ARA70 0.034 0.025 -9999 0 -0.042 10 10
LATS2 0 0 -9999 0 -10000 0 0
T-DHT/AR/PRX1 0.041 0.015 -9999 0 -0.035 8 8
Cyclin D3/CDK11 p58 0.024 0.002 -9999 0 -10000 0 0
VAV3 0.026 0.025 -9999 0 -0.062 36 36
KLK2 0.004 0.019 -9999 0 -0.28 1 1
CASP8 0.031 0.013 -9999 0 -0.063 9 9
T-DHT/AR/TIF2/CARM1 0.059 0.024 -9999 0 -10000 0 0
TMPRSS2 0.004 0.026 -9999 0 -0.17 6 6
CCND1 0.015 0.036 -9999 0 -0.063 90 90
PIAS1 0.033 0.004 -9999 0 -10000 0 0
mol:T-DHT 0.001 0.001 -9999 0 -0.009 6 6
CDC2L1 0 0 -9999 0 -10000 0 0
PIAS4 0.033 0.006 -9999 0 -10000 0 0
T-DHT/AR/CDK6 0.03 0.025 -9999 0 -0.039 5 5
CMTM2 0 0 -9999 0 -10000 0 0
SNURF 0 0 -9999 0 -10000 0 0
ZMIZ1 0.024 0.016 -9999 0 -0.029 3 3
CCND3 0.032 0.003 -9999 0 -10000 0 0
TGIF1 -0.033 0.043 -9999 0 -0.063 343 343
FKBP4 0.032 0.007 -9999 0 -10000 0 0
Retinoic acid receptors-mediated signaling

Figure S75.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S75.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.02 0.031 -10000 0 -0.063 61 61
HDAC3 0.032 0.004 -10000 0 -10000 0 0
VDR 0.031 0.006 -10000 0 -10000 0 0
Cbp/p300/PCAF 0.04 0.012 -10000 0 -10000 0 0
EP300 0.03 0.008 -10000 0 -10000 0 0
RARs/AIB1/Cbp/p300/PCAF/9cRA -0.002 0.057 -10000 0 -0.18 32 32
KAT2B 0 0 -10000 0 -10000 0 0
MAPK14 0.032 0.005 -10000 0 -0.063 1 1
AKT1 0.004 0.053 0.14 6 -0.19 16 22
RAR alpha/9cRA/Cyclin H 0.007 0.088 0.2 3 -0.22 16 19
mol:9cRA 0 0 -10000 0 -10000 0 0
RARs/Src-1/Cbp/p300/PCAF/9cRA -0.003 0.052 0.091 7 -0.15 43 50
CDC2 0 0.001 -10000 0 -10000 0 0
response to UV 0 0.001 -10000 0 -10000 0 0
RAR alpha/Jnk1 0.017 0.045 0.15 1 -0.16 22 23
NCOR2 0.032 0.004 -10000 0 -10000 0 0
VDR/VDR/Vit D3 0.023 0.005 -10000 0 -10000 0 0
RXRs/RARs/NRIP1/9cRA -0.002 0.073 0.3 3 -0.32 11 14
NCOA2 0.032 0.004 -10000 0 -10000 0 0
NCOA3 0.03 0.011 -10000 0 -0.063 2 2
NCOA1 0.031 0.007 -10000 0 -10000 0 0
VDR/VDR/DNA 0.031 0.006 -10000 0 -10000 0 0
RARG 0.032 0.005 -10000 0 -10000 0 0
RAR gamma1/9cRA 0.042 0.01 -10000 0 -10000 0 0
MAPK3 0.033 0.003 -10000 0 -10000 0 0
MAPK1 0.03 0.009 -10000 0 0 42 42
MAPK8 0.025 0.014 -10000 0 -0.027 1 1
mol:Vit D3 0 0 -10000 0 -10000 0 0
RXRs/VDR/DNA/Vit D3 0.009 0.072 -10000 0 -0.29 17 17
RARA 0.011 0.007 -10000 0 -10000 0 0
negative regulation of phosphoinositide 3-kinase cascade 0 0 -10000 0 -10000 0 0
RARs/TIF2/Cbp/p300/PCAF/9cRA -0.002 0.051 0.098 8 -0.15 40 48
PRKCA 0.033 0.007 -10000 0 -0.036 4 4
RXRs/RARs/NRIP1/9cRA/HDAC1 0.002 0.069 0.35 1 -0.31 11 12
RXRG 0.019 0.007 -10000 0 -10000 0 0
RXRA -0.013 0.044 0.1 8 -0.099 4 12
RXRB 0.019 0.007 -10000 0 -0.04 1 1
VDR/Vit D3/DNA 0.023 0.005 -10000 0 -10000 0 0
RBP1 -0.01 0.046 -10000 0 -0.063 222 222
CRBP1/9-cic-RA -0.004 0.031 -10000 0 -0.039 222 222
RARB 0.032 0.007 -10000 0 -0.025 4 4
PRKCG 0.031 0.01 -10000 0 -0.036 4 4
MNAT1 0.03 0.009 -10000 0 -0.063 1 1
RAR alpha/RXRs 0.003 0.08 0.2 1 -0.33 17 18
RXRs/RARs/SMRT(N-CoR2)/9cRA 0.002 0.067 0.24 2 -0.27 15 17
proteasomal ubiquitin-dependent protein catabolic process -0.009 0.064 0.16 3 -0.18 35 38
RXRs/RARs/NRIP1/9cRA/HDAC3 0.003 0.068 0.3 1 -0.34 6 7
positive regulation of DNA binding 0.001 0.08 0.15 2 -0.21 16 18
NRIP1 0.008 0.068 0.3 2 -0.39 2 4
RXRs/RARs 0.008 0.067 -10000 0 -0.31 12 12
RXRs/RXRs/DNA/9cRA -0.004 0.065 -10000 0 -0.28 18 18
PRKACA 0.032 0.006 -10000 0 0 17 17
CDK7 0.032 0.007 -10000 0 -0.063 2 2
TFIIH 0.057 0.029 -10000 0 -0.048 8 8
RAR alpha/9cRA 0.024 0.082 -10000 0 -0.21 8 8
CCNH 0.032 0.004 -10000 0 -10000 0 0
CREBBP 0.032 0.004 -10000 0 -10000 0 0
RAR gamma2/9cRA 0.053 0.034 -10000 0 -10000 0 0
IL2 signaling events mediated by PI3K

Figure S76.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S76.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.01 0.047 0.2 10 -0.2 4 14
UGCG 0.008 0.072 -10000 0 -0.58 7 7
AKT1/mTOR/p70S6K/Hsp90/TERT -0.003 0.092 0.24 2 -0.31 25 27
mol:GTP 0 0 -10000 0 -10000 0 0
mol:glucosylceramide 0.008 0.071 -10000 0 -0.57 7 7
mol:DAG -0.18 0.35 -10000 0 -0.8 122 122
CaM/Ca2+/Calcineurin A alpha-beta B1 0.003 0.077 0.26 2 -0.25 10 12
FRAP1 -0.007 0.079 0.28 2 -0.27 13 15
FOXO3 -0.013 0.079 0.25 3 -0.26 19 22
AKT1 -0.01 0.08 0.26 1 -0.27 19 20
GAB2 0.031 0.006 -10000 0 -10000 0 0
SMPD1 -0.001 0.1 -10000 0 -0.59 15 15
SGMS1 -0.13 0.26 -10000 0 -0.6 122 122
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
mol:GDP -0.016 0.007 -10000 0 -0.042 6 6
CALM1 0.029 0.01 -10000 0 -10000 0 0
cell proliferation -0.063 0.16 -10000 0 -0.35 107 107
EIF3A 0.024 0.015 -10000 0 -10000 0 0
PI3K 0.04 0.023 -10000 0 -0.049 16 16
RPS6KB1 0.02 0.037 -10000 0 -0.74 1 1
mol:sphingomyelin -0.18 0.35 -10000 0 -0.8 122 122
natural killer cell activation 0 0.001 -10000 0 -0.004 5 5
JAK3 0.032 0.006 -10000 0 -10000 0 0
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
JAK1 0.032 0.006 -10000 0 -10000 0 0
NFKB1 0.031 0.009 -10000 0 -0.063 4 4
MYC -0.015 0.085 0.25 3 -0.28 14 17
MYB 0.015 0.026 -10000 0 -0.34 1 1
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K -0.009 0.071 0.14 3 -0.21 27 30
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 0.042 0.047 -10000 0 -0.71 1 1
mol:PI-3-4-5-P3 -0.009 0.07 0.14 3 -0.21 26 29
Rac1/GDP 0.005 0.019 -10000 0 -0.045 5 5
T cell proliferation -0.009 0.066 0.13 3 -0.2 25 28
SHC1 0.024 0.026 -10000 0 -0.064 40 40
RAC1 0.023 0.015 -10000 0 -10000 0 0
positive regulation of cyclin-dependent protein kinase activity 0.001 0.002 -10000 0 -10000 0 0
PRKCZ -0.01 0.067 0.13 3 -0.2 26 29
NF kappa B1 p50/RelA 0.008 0.091 0.28 2 -0.26 13 15
IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K 0.014 0.044 -10000 0 -0.2 10 10
HSP90AA1 0.03 0.008 -10000 0 -10000 0 0
RELA 0.032 0.004 -10000 0 -10000 0 0
IL2RA 0.023 0.017 -10000 0 -0.063 6 6
IL2RB 0.03 0.012 -10000 0 -0.064 4 4
TERT 0.032 0.006 -10000 0 -10000 0 0
E2F1 0.024 0.024 -10000 0 -0.38 1 1
SOS1 0 0.001 -10000 0 -0.003 4 4
RPS6 0.028 0.011 -10000 0 -10000 0 0
mol:cAMP -0.001 0.001 -10000 0 -10000 0 0
PTPN11 0.032 0.003 -10000 0 -10000 0 0
IL2RG 0.031 0.013 -10000 0 -0.064 9 9
actin cytoskeleton organization -0.009 0.066 0.13 3 -0.2 25 28
GRB2 0.031 0.006 -10000 0 -10000 0 0
IL2 0.032 0.004 -10000 0 -10000 0 0
PIK3CA 0.029 0.018 -10000 0 -0.063 17 17
Rac1/GTP 0.032 0.032 -10000 0 -10000 0 0
LCK 0.031 0.01 -10000 0 -0.063 4 4
BCL2 -0.005 0.074 0.26 7 -0.25 5 12
Class I PI3K signaling events

Figure S77.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S77.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ARF5/GTP -0.02 0.031 0.16 7 -10000 0 7
DAPP1 0.005 0.061 0.15 22 -0.24 10 32
Src family/SYK family/BLNK-LAT/BTK-ITK -0.004 0.07 0.32 1 -0.27 15 16
mol:DAG -0.005 0.054 0.21 14 -0.12 5 19
HRAS 0.035 0.01 0.08 3 -10000 0 3
RAP1A 0.035 0.008 -10000 0 0 9 9
ARF5/GDP 0.016 0.056 0.14 3 -0.23 17 20
PLCG2 0.03 0.014 -10000 0 -0.063 10 10
PLCG1 0.03 0.009 -10000 0 -10000 0 0
ARF5 0.023 0.015 -10000 0 -10000 0 0
mol:GTP -0.021 0.041 0.18 13 -10000 0 13
ARF1/GTP -0.014 0.031 0.15 11 -0.11 1 12
RHOA 0.032 0.006 -10000 0 -10000 0 0
YES1 0.017 0.034 -10000 0 -0.063 75 75
RAP1A/GTP -0.022 0.032 0.15 10 -10000 0 10
ADAP1 -0.021 0.036 0.16 12 -10000 0 12
ARAP3 -0.021 0.04 0.18 13 -10000 0 13
INPPL1 0.032 0.004 -10000 0 -10000 0 0
PREX1 0 0 -10000 0 -10000 0 0
ARHGEF6 0.03 0.012 -10000 0 -0.063 7 7
ARHGEF7 0.031 0.007 -10000 0 -10000 0 0
ARF1 0.032 0.006 -10000 0 -10000 0 0
NRAS 0.012 0.042 -10000 0 -0.059 124 124
FYN 0.029 0.011 -10000 0 -0.063 1 1
ARF6 0.031 0.008 -10000 0 -10000 0 0
FGR 0.029 0.017 -10000 0 -0.063 15 15
mol:Ca2+ -0.004 0.037 0.13 23 -10000 0 23
mol:IP4 0 0 -10000 0 -10000 0 0
TIAM1 0.031 0.008 -10000 0 -10000 0 0
ZAP70 0.032 0.002 -10000 0 -10000 0 0
mol:IP3 -0.008 0.042 0.15 21 -10000 0 21
LYN 0.021 0.031 -10000 0 -0.063 60 60
ARF1/GDP 0.028 0.066 0.16 6 -0.22 23 29
RhoA/GDP 0.037 0.065 0.17 29 -0.12 6 35
PDK1/Src/Hsp90 0.055 0.029 -10000 0 -0.044 2 2
BLNK 0.013 0.031 -10000 0 -0.063 59 59
actin cytoskeleton reorganization 0.027 0.08 0.17 85 -0.18 7 92
SRC 0.031 0.008 -10000 0 -10000 0 0
PLEKHA2 -0.017 0.003 -10000 0 -10000 0 0
RAC1 0.023 0.015 -10000 0 -10000 0 0
PTEN 0.023 0.019 -10000 0 -0.039 15 15
HSP90AA1 0.03 0.008 -10000 0 -10000 0 0
ARF6/GTP -0.023 0.042 0.19 12 -10000 0 12
RhoA/GTP -0.023 0.043 0.19 13 -10000 0 13
Src family/SYK family/BLNK-LAT -0.019 0.068 -10000 0 -0.19 40 40
BLK 0.032 0.005 -10000 0 -10000 0 0
PDPK1 0.032 0.004 -10000 0 -10000 0 0
CYTH1 -0.021 0.036 0.16 12 -10000 0 12
HCK 0.014 0.036 -10000 0 -0.063 85 85
CYTH3 -0.021 0.036 0.16 12 -10000 0 12
CYTH2 -0.021 0.036 0.16 12 -10000 0 12
KRAS 0.034 0.011 0.079 1 -10000 0 1
GO:0030676 0 0 -10000 0 -10000 0 0
FOXO3 -0.005 0.028 0.3 1 -0.17 7 8
SGK1 0.001 0.03 -10000 0 -0.17 11 11
INPP5D 0 0 -10000 0 -10000 0 0
mol:GDP 0.012 0.066 0.15 11 -0.22 24 35
SOS1 0 0 -10000 0 -10000 0 0
SYK 0.025 0.024 -10000 0 -0.063 34 34
ARF6/GDP -0.018 0.043 0.19 12 -0.13 3 15
mol:PI-3-4-5-P3 -0.023 0.031 0.14 11 -10000 0 11
ARAP3/RAP1A/GTP -0.022 0.033 0.15 10 -10000 0 10
VAV1 0.032 0.007 -10000 0 -0.063 1 1
mol:PI-3-4-P2 -0.011 0.001 -10000 0 -10000 0 0
RAS family/GTP/PI3K Class I 0.057 0.081 0.2 95 -0.069 3 98
PLEKHA1 -0.011 0.009 -10000 0 -10000 0 0
Rac1/GDP 0.017 0.058 0.17 4 -0.23 18 22
LAT 0.032 0.005 -10000 0 -0.063 1 1
Rac1/GTP 0.022 0.061 0.14 2 -0.24 18 20
ITK -0.025 0.038 0.16 11 -10000 0 11
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma -0.011 0.059 0.26 8 -0.16 6 14
LCK 0.031 0.01 -10000 0 -0.063 4 4
BTK -0.025 0.041 0.17 13 -10000 0 13
PDGFR-beta signaling pathway

Figure S78.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S78.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
S1P1/Sphingosine-1-phosphate 0.026 0.07 0.22 30 -0.32 5 35
PDGFB-D/PDGFRB/SLAP 0.04 0.026 -10000 0 -0.051 34 34
PDGFB-D/PDGFRB/APS/CBL 0.043 0.009 -10000 0 -0.04 2 2
AKT1 -0.019 0.078 0.29 13 -10000 0 13
mol:PI-4-5-P2 0 0.001 -10000 0 -10000 0 0
mol:Sphingosine-1-phosphate 0.035 0.075 0.24 32 -0.36 5 37
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
FGR 0.009 0.063 0.2 12 -0.37 7 19
mol:Ca2+ 0.024 0.071 0.22 29 -0.39 5 34
MYC 0.045 0.12 0.29 44 -0.31 4 48
SHC1 0.024 0.026 -10000 0 -0.063 40 40
HRAS/GDP -0.017 0.053 0.17 36 -10000 0 36
LRP1/PDGFRB/PDGFB 0.054 0.031 -10000 0 -0.043 33 33
GRB10 0.021 0.018 -10000 0 -0.063 6 6
PTPN11 0.032 0.003 -10000 0 -10000 0 0
GO:0007205 0.024 0.072 0.22 29 -0.4 5 34
PTEN 0.023 0.016 -10000 0 -0.063 2 2
GRB2 0.032 0.006 -10000 0 -10000 0 0
GRB7 0.032 0.005 -10000 0 -0.063 1 1
PDGFB-D/PDGFRB/SHP2 0.047 0.01 -10000 0 -0.05 2 2
PDGFB-D/PDGFRB/GRB10 0.031 0.025 -10000 0 -0.05 8 8
cell cycle arrest 0.04 0.026 -10000 0 -0.051 34 34
HRAS 0.031 0.007 -10000 0 -10000 0 0
HIF1A -0.023 0.071 0.27 13 -10000 0 13
GAB1 0.019 0.077 0.24 23 -0.34 8 31
mol:GTP 0 0 -10000 0 -10000 0 0
DNM2 0.015 0.083 0.24 36 -0.28 8 44
PDGFB-D/PDGFRB 0.055 0.026 -10000 0 -0.048 10 10
mol:GDP 0 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB/LMW-PTP 0.047 0.011 -10000 0 -0.05 2 2
S1P1/Sphingosine-1-phosphate/PDGFB-D/PDGFRB 0.01 0.053 0.2 10 -0.26 5 15
positive regulation of MAPKKK cascade 0.047 0.01 -10000 0 -0.05 2 2
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
mol:IP3 0.024 0.072 0.22 29 -0.4 5 34
E5 -0.001 0.001 -10000 0 -10000 0 0
CSK 0.031 0.01 -10000 0 -0.032 10 10
PDGFB-D/PDGFRB/GRB7 0.047 0.011 -10000 0 -0.05 3 3
SHB 0.03 0.009 -10000 0 -10000 0 0
BLK 0.009 0.058 0.24 3 -0.36 7 10
PTPN2 0.032 0.006 -10000 0 -10000 0 0
PDGFB-D/PDGFRB/SNX15 0.047 0.01 -10000 0 -0.05 2 2
BCAR1 0 0 -10000 0 -10000 0 0
VAV2 0.016 0.084 0.25 25 -0.34 8 33
CBL 0.032 0.004 -10000 0 -10000 0 0
PDGFB-D/PDGFRB/DEP1 0.046 0.011 -10000 0 -0.05 2 2
LCK 0.013 0.057 0.2 17 -0.34 5 22
PDGFRB 0.032 0.008 -10000 0 -0.052 3 3
ACP1 0.032 0.005 -10000 0 -10000 0 0
HCK 0 0.035 -10000 0 -10000 0 0
ABL1 0.02 0.073 0.22 31 -0.27 8 39
PDGFB-D/PDGFRB/CBL 0.023 0.08 0.26 13 -0.38 8 21
PTPN1 0.03 0.009 -10000 0 -10000 0 0
SNX15 0.032 0.004 -10000 0 -10000 0 0
STAT3 0.03 0.014 -10000 0 -0.063 10 10
STAT1 0.029 0.018 -10000 0 -0.063 18 18
cell proliferation 0.045 0.11 0.23 91 -0.29 4 95
SLA 0.026 0.024 -10000 0 -0.063 33 33
actin cytoskeleton reorganization -0.016 0.067 0.2 41 -10000 0 41
SRC 0.01 0.044 -10000 0 -0.73 1 1
PI3K -0.043 0.021 -10000 0 -0.093 2 2
PDGFB-D/PDGFRB/GRB7/SHC 0.054 0.035 -10000 0 -0.048 46 46
SH2B2 0 0 -10000 0 -10000 0 0
PLCgamma1/SPHK1 0.035 0.076 0.24 31 -0.37 5 36
LYN 0.004 0.041 -10000 0 -0.35 1 1
LRP1 0.029 0.016 -10000 0 -0.063 13 13
SOS1 0 0 -10000 0 -10000 0 0
STAT5B 0.032 0.004 -10000 0 -10000 0 0
STAT5A 0.032 0.005 -10000 0 -0.063 1 1
NCK1-2/p130 Cas 0.066 0.038 -10000 0 -10000 0 0
SPHK1 0.029 0.019 -10000 0 -0.063 19 19
EDG1 0 0.003 -10000 0 -10000 0 0
mol:DAG 0.024 0.072 0.22 29 -0.4 5 34
PLCG1 0.024 0.073 0.22 29 -0.41 5 34
NHERF/PDGFRB 0.063 0.018 -10000 0 -0.043 9 9
YES1 -0.006 0.095 0.24 1 -0.57 11 12
cell migration 0.062 0.018 -10000 0 -0.043 9 9
SHC/Grb2/SOS1 0.058 0.045 -10000 0 -0.078 1 1
SLC9A3R2 0.032 0.004 -10000 0 -10000 0 0
SLC9A3R1 0.032 0.007 -10000 0 -0.063 2 2
NHERF1-2/PDGFRB/PTEN 0.046 0.056 -10000 0 -0.053 6 6
FYN -0.019 0.11 -10000 0 -0.36 44 44
DOK1 -0.016 0.053 0.17 38 -10000 0 38
HRAS/GTP 0.023 0.005 -10000 0 -10000 0 0
PDGFB 0.03 0.008 -10000 0 -10000 0 0
RAC1 0.055 0.12 0.25 99 -0.42 4 103
PRKCD -0.015 0.053 0.17 37 -10000 0 37
FER -0.016 0.053 0.17 36 -10000 0 36
MAPKKK cascade -0.011 0.072 0.18 57 -10000 0 57
RASA1 -0.015 0.053 0.17 36 -10000 0 36
NCK1 0.03 0.015 -10000 0 -0.063 11 11
NCK2 0.032 0.004 -10000 0 -10000 0 0
p62DOK/Csk -0.02 0.052 0.17 37 -10000 0 37
PDGFB-D/PDGFRB/SHB 0.044 0.015 -10000 0 -0.05 2 2
chemotaxis 0.02 0.072 0.21 31 -0.27 8 39
STAT1-3-5/STAT1-3-5 0.063 0.043 -10000 0 -0.092 1 1
Bovine Papilomavirus E5/PDGFRB 0.023 0.006 0.052 2 -0.04 2 4
PTPRJ 0.032 0.006 -10000 0 -10000 0 0
Syndecan-2-mediated signaling events

Figure S79.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S79.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Syndecan-2/Fibronectin 0.016 0.027 -10000 0 -0.059 6 6
EPHB2 0.031 0.007 -10000 0 -0.063 1 1
Syndecan-2/TACI 0.027 0.011 -10000 0 -0.052 5 5
LAMA1 0 0 -10000 0 -10000 0 0
Syndecan-2/alpha2 ITGB1 0.024 0.053 -10000 0 -0.071 4 4
HRAS 0.031 0.007 -10000 0 -10000 0 0
Syndecan-2/CASK -0.007 0.005 -10000 0 -0.062 1 1
ITGA5 0.019 0.033 -10000 0 -0.063 68 68
BAX -0.012 0.012 -10000 0 -0.12 3 3
EPB41 0.032 0.005 -10000 0 -10000 0 0
positive regulation of cell-cell adhesion 0.025 0.01 -10000 0 -0.046 5 5
LAMA3 0.029 0.017 -10000 0 -0.063 15 15
EZR 0 0 -10000 0 -10000 0 0
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
CAV2 0.014 0.029 -10000 0 -0.063 49 49
Syndecan-2/MMP2 -0.003 0.034 -10000 0 -0.066 7 7
RP11-540L11.1 0 0 -10000 0 -10000 0 0
alpha2 ITGB1 0.024 0.035 -10000 0 -0.05 64 64
dendrite morphogenesis 0.027 0.012 -10000 0 -0.052 5 5
Syndecan-2/GM-CSF 0.027 0.011 -10000 0 -0.052 5 5
determination of left/right symmetry -0.009 0.006 -10000 0 -0.077 1 1
Syndecan-2/PKC delta 0.027 0.012 -10000 0 -0.052 5 5
GNB2L1 0.032 0.004 -10000 0 -10000 0 0
MAPK3 -0.018 0.026 0.19 8 -10000 0 8
MAPK1 -0.017 0.027 0.19 8 -10000 0 8
Syndecan-2/RACK1 0.041 0.02 -10000 0 -0.065 1 1
NF1 0.032 0.003 -10000 0 -10000 0 0
FGFR/FGF/Syndecan-2 -0.009 0.006 -10000 0 -0.077 1 1
ITGA2 0.015 0.036 -10000 0 -0.063 90 90
MAPK8 -0.011 0.009 -10000 0 -0.1 1 1
Syndecan-2/alpha2/beta1 Integrin 0.016 0.039 -10000 0 -0.056 5 5
Syndecan-2/Kininogen 0.027 0.011 -10000 0 -0.054 4 4
ITGB1 0.025 0.014 -10000 0 -10000 0 0
SRC -0.02 0.028 0.17 9 -10000 0 9
Syndecan-2/CASK/Protein 4.1 0.025 0.011 -10000 0 -0.046 5 5
extracellular matrix organization 0.023 0.018 -10000 0 -0.053 6 6
actin cytoskeleton reorganization 0.016 0.027 -10000 0 -0.058 6 6
Syndecan-2/Caveolin-2/Ras 0.023 0.031 -10000 0 -0.057 4 4
Syndecan-2/Laminin alpha3 0.026 0.015 -10000 0 -0.057 5 5
Syndecan-2/RasGAP 0.054 0.027 -10000 0 -0.069 1 1
alpha5/beta1 Integrin 0.025 0.034 -10000 0 -0.05 61 61
PRKCD 0.032 0.006 -10000 0 -10000 0 0
Syndecan-2 dimer 0.027 0.012 -10000 0 -0.052 5 5
GO:0007205 0.001 0.003 -10000 0 -10000 0 0
DNA mediated transformation 0 0 -10000 0 -10000 0 0
Syndecan-2/RasGAP/Src 0.027 0.023 0.18 3 -10000 0 3
RHOA 0.032 0.006 -10000 0 -10000 0 0
SDCBP 0.032 0.004 -10000 0 -10000 0 0
TNFRSF13B 0.032 0.004 -10000 0 -10000 0 0
RASA1 0.032 0.006 -10000 0 -10000 0 0
alpha2/beta1 Integrin 0.024 0.035 -10000 0 -0.05 64 64
Syndecan-2/Synbindin 0.027 0.011 -10000 0 -0.052 5 5
TGFB1 0.026 0.022 -10000 0 -0.063 26 26
CASP3 -0.021 0.027 0.19 7 -10000 0 7
FN1 0.014 0.037 -10000 0 -0.063 96 96
Syndecan-2/IL8 0.013 0.029 -10000 0 -0.053 6 6
SDC2 -0.009 0.006 -10000 0 -0.077 1 1
KNG1 0.032 0.006 -10000 0 -10000 0 0
Syndecan-2/Neurofibromin 0.028 0.011 -10000 0 -0.052 5 5
TRAPPC4 0.032 0.005 -10000 0 -10000 0 0
CSF2 0.032 0.004 -10000 0 -10000 0 0
Syndecan-2/TGFB1 0.023 0.018 -10000 0 -0.053 6 6
Syndecan-2/Syntenin/PI-4-5-P2 0.025 0.01 -10000 0 -0.046 5 5
Syndecan-2/Ezrin 0.025 0.011 -10000 0 -0.046 5 5
PRKACA -0.017 0.028 0.19 9 -10000 0 9
angiogenesis 0.013 0.029 -10000 0 -0.053 6 6
MMP2 -0.013 0.047 -10000 0 -0.063 241 241
IL8 0.012 0.039 -10000 0 -0.063 110 110
calcineurin-NFAT signaling pathway 0.027 0.011 -10000 0 -0.052 5 5
Presenilin action in Notch and Wnt signaling

Figure S80.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S80.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Delta 1/NOTCH/NOTCH(cleaved) 0.011 0.083 -10000 0 -0.39 19 19
HDAC1 0.022 0.031 -10000 0 -0.059 61 61
AES 0.032 0.007 -10000 0 -10000 0 0
FBXW11 0.032 0.005 -10000 0 -10000 0 0
DTX1 0 0 -10000 0 -10000 0 0
LRP6/FZD1 0.032 0.024 -10000 0 -0.05 4 4
TLE1 0.032 0.006 -10000 0 -10000 0 0
AP1 0.002 0.022 -10000 0 -0.14 4 4
NCSTN 0.027 0.022 -10000 0 -0.063 28 28
ADAM10 0.028 0.018 -10000 0 -0.063 18 18
Beta Catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 0.021 0.058 -10000 0 -0.51 4 4
NICD/RBPSUH 0.028 0.088 -10000 0 -0.39 19 19
WIF1 0.004 0.01 -10000 0 -10000 0 0
NOTCH1 0.012 0.082 -10000 0 -0.44 15 15
PSENEN 0.031 0.007 -10000 0 -10000 0 0
KREMEN2 0.032 0.003 -10000 0 -10000 0 0
DKK1 0.006 0.037 -10000 0 -0.063 101 101
beta catenin/beta TrCP1 0.063 0.078 0.2 77 -0.23 6 83
APH1B 0.032 0.005 -10000 0 -10000 0 0
APH1A 0.031 0.012 -10000 0 -0.063 7 7
AXIN1 0.026 0.047 0.26 4 -0.25 1 5
CtBP/CBP/TCF1/TLE1/AES 0.022 0.031 -10000 0 -0.12 11 11
PSEN1 0.03 0.008 -10000 0 -10000 0 0
FOS 0.007 0.04 -10000 0 -0.063 120 120
JUN 0.032 0.005 -10000 0 -10000 0 0
MAP3K7 0.031 0.009 -10000 0 -0.063 1 1
CTNNB1 0.048 0.08 0.19 87 -0.23 6 93
MAPK3 0.032 0.002 -10000 0 -10000 0 0
DKK2/LRP6/Kremen 2 0.059 0.025 -10000 0 -0.04 23 23
HNF1A 0.033 0.003 -10000 0 -10000 0 0
CTBP1 0.032 0.006 -10000 0 -10000 0 0
MYC -0.005 0.065 -10000 0 -0.74 1 1
NKD1 0 0.001 -10000 0 -10000 0 0
FZD1 0.022 0.017 -10000 0 -0.063 4 4
NOTCH1 precursor/Deltex homolog 1 0.005 0.081 -10000 0 -0.39 19 19
apoptosis 0.002 0.022 -10000 0 -0.14 4 4
Delta 1/NOTCHprecursor 0.005 0.081 -10000 0 -0.39 19 19
DLL1 0 0 -10000 0 -10000 0 0
PPARD 0.018 0.063 -10000 0 -0.78 3 3
Gamma Secretase 0.071 0.053 -10000 0 -0.076 2 2
APC 0.01 0.084 0.26 3 -0.33 20 23
DVL1 0.018 0.021 -10000 0 -0.21 2 2
CSNK2A1 0.03 0.008 -10000 0 -10000 0 0
MAP3K7IP1 0.001 0.002 -10000 0 -10000 0 0
DKK1/LRP6/Kremen 2 0.017 0.053 -10000 0 -0.048 102 102
LRP6 0.031 0.007 -10000 0 -10000 0 0
CSNK1A1 0.032 0.004 -10000 0 -10000 0 0
NLK 0.014 0.006 -10000 0 -0.038 1 1
CCND1 -0.005 0.1 -10000 0 -0.8 7 7
WNT1 0.031 0.006 -10000 0 -10000 0 0
Axin1/APC/beta catenin 0.043 0.085 0.26 17 -0.46 3 20
DKK2 0.031 0.012 -10000 0 -0.031 16 16
NOTCH1 precursor/DVL1 0.034 0.091 0.25 1 -0.39 15 16
GSK3B 0.032 0.006 -10000 0 -10000 0 0
FRAT1 0.025 0.014 -10000 0 -10000 0 0
NOTCH/Deltex homolog 1 0.011 0.083 -10000 0 -0.39 19 19
PPP2R5D 0.015 0.03 -10000 0 -0.39 2 2
MAPK1 0.03 0.009 -10000 0 0 42 42
WNT1/LRP6/FZD1 0.007 0.024 -10000 0 -10000 0 0
RBPJ 0.032 0.004 -10000 0 -10000 0 0
CREBBP 0.031 0.005 -10000 0 -0.022 1 1
Syndecan-3-mediated signaling events

Figure S81.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S81.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CTTN 0.032 0.004 -10000 0 -10000 0 0
Syndecan-3/Src/Cortactin 0.03 0.07 -10000 0 -0.27 17 17
Syndecan-3/Neurocan 0.011 0.068 -10000 0 -0.29 21 21
POMC 0.032 0.004 -10000 0 -10000 0 0
EGFR 0.012 0.018 -10000 0 -0.063 6 6
Syndecan-3/EGFR 0 0.063 -10000 0 -0.32 14 14
AGRP 0.032 0.004 -10000 0 -10000 0 0
NCSTN 0.027 0.022 -10000 0 -0.063 28 28
PSENEN 0.031 0.007 -10000 0 -10000 0 0
RP11-540L11.1 0 0 -10000 0 -10000 0 0
APH1B 0.032 0.005 -10000 0 -10000 0 0
APH1A 0.031 0.012 -10000 0 -0.063 7 7
NCAN 0.026 0.014 -10000 0 -0.063 2 2
long-term memory 0.029 0.076 -10000 0 -0.3 22 22
Syndecan-3/IL8 0.003 0.082 -10000 0 -0.35 22 22
PSEN1 0.03 0.008 -10000 0 -10000 0 0
Src/Cortactin 0.045 0.013 -10000 0 -10000 0 0
FYN 0.029 0.011 -10000 0 -0.063 1 1
limb bud formation -0.006 0.074 -10000 0 -0.36 20 20
MC4R 0.031 0.007 -10000 0 -0.063 1 1
SRC 0.031 0.008 -10000 0 -10000 0 0
PTN 0.021 0.015 -10000 0 -10000 0 0
FGFR/FGF/Syndecan-3 -0.006 0.074 -10000 0 -0.36 20 20
neuron projection morphogenesis 0.014 0.086 0.16 105 -0.3 5 110
Syndecan-3/AgRP 0.015 0.081 -10000 0 -0.35 22 22
Syndecan-3/AgRP/MC4R 0.031 0.084 -10000 0 -0.34 22 22
Fyn/Cortactin 0.043 0.016 -10000 0 -0.05 1 1
SDC3 -0.006 0.075 -10000 0 -0.37 20 20
GO:0007205 0 0 -10000 0 -10000 0 0
positive regulation of leukocyte migration 0.003 0.081 -10000 0 -0.35 22 22
IL8 0.012 0.039 -10000 0 -0.063 110 110
Syndecan-3/Fyn/Cortactin 0.03 0.077 -10000 0 -0.3 22 22
Syndecan-3/CASK -0.008 0.073 -10000 0 -0.34 22 22
alpha-MSH/MC4R 0.046 0.011 -10000 0 -0.05 1 1
Gamma Secretase 0.072 0.053 -10000 0 -0.078 1 1
EPHB forward signaling

Figure S82.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S82.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Ephrin A5/EPHB2 0.042 0.01 -10000 0 -0.04 1 1
cell-cell adhesion 0.029 0.024 -10000 0 -10000 0 0
Ephrin B/EPHB2/RasGAP 0.077 0.045 -10000 0 -10000 0 0
ITSN1 0.032 0.005 -10000 0 -10000 0 0
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
SHC1 0.024 0.026 -10000 0 -0.063 40 40
Ephrin B1/EPHB3 0.041 0.013 -10000 0 -0.04 7 7
Ephrin B1/EPHB1 0.042 0.013 -10000 0 -0.04 9 9
HRAS/GDP 0.021 0.051 -10000 0 -0.15 24 24
Ephrin B/EPHB1/GRB7 0.078 0.046 -10000 0 -0.075 1 1
Endophilin/SYNJ1 -0.023 0.038 0.18 13 -10000 0 13
KRAS 0.031 0.008 -10000 0 -10000 0 0
Ephrin B/EPHB1/Src 0.073 0.048 -10000 0 -0.075 1 1
endothelial cell migration 0.037 0.038 -10000 0 -0.053 1 1
GRB2 0.032 0.006 -10000 0 -10000 0 0
GRB7 0.032 0.005 -10000 0 -0.063 1 1
PAK1 -0.028 0.047 0.18 18 -10000 0 18
HRAS 0.031 0.007 -10000 0 -10000 0 0
RRAS -0.022 0.045 0.19 16 -10000 0 16
DNM1 0.006 0.012 -10000 0 -10000 0 0
cell-cell signaling 0 0 -10000 0 -10000 0 0
CRK -0.024 0.038 0.17 13 -10000 0 13
lamellipodium assembly -0.029 0.024 -10000 0 -10000 0 0
Ephrin B/EPHB1/Src/p52 SHC/GRB2 0.018 0.035 -10000 0 -0.2 5 5
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
EPHB2 0.031 0.007 -10000 0 -0.063 1 1
EPHB3 0.03 0.013 -10000 0 -0.063 7 7
EPHB1 0.03 0.013 -10000 0 -0.063 9 9
EPHB4 0.023 0.015 -10000 0 -10000 0 0
mol:GDP -0.011 0.043 0.15 13 -0.16 19 32
Ephrin B/EPHB2 0.063 0.035 -10000 0 -10000 0 0
Ephrin B/EPHB3 0.062 0.036 -10000 0 -0.054 2 2
JNK cascade -0.027 0.053 0.24 17 -10000 0 17
Ephrin B/EPHB1 0.062 0.037 -10000 0 -0.057 2 2
RAP1/GDP 0.029 0.1 0.19 128 -0.18 13 141
EFNB2 0.03 0.01 -10000 0 -10000 0 0
EFNB3 0.031 0.006 -10000 0 -10000 0 0
EFNB1 0.032 0.002 -10000 0 -10000 0 0
Ephrin B2/EPHB1-2 0.05 0.03 -10000 0 -0.035 41 41
RAP1B 0 0 -10000 0 -10000 0 0
RAP1A 0.032 0.004 -10000 0 -10000 0 0
CDC42/GTP 0.057 0.049 0.14 1 -0.11 21 22
Rap1/GTP -0.044 0.016 -10000 0 -10000 0 0
axon guidance 0.041 0.01 -10000 0 -0.039 1 1
MAPK3 -0.007 0.035 0.17 3 -0.27 2 5
MAPK1 -0.007 0.032 0.16 2 -0.19 4 6
Rac1/GDP -0.006 0.066 0.21 31 -0.18 12 43
actin cytoskeleton reorganization -0.035 0.033 0.034 1 -0.13 20 21
CDC42/GDP 0.036 0.11 0.2 135 -0.18 13 148
PI3K 0.041 0.042 -10000 0 -0.054 1 1
EFNA5 0.032 0.004 -10000 0 -10000 0 0
Ephrin B2/EPHB4 0.028 0.021 -10000 0 -10000 0 0
Ephrin B/EPHB2/Intersectin/N-WASP 0.012 0.032 -10000 0 -0.12 23 23
CDC42 0.031 0.006 -10000 0 -10000 0 0
RAS family/GTP -0.05 0.022 -10000 0 -0.095 1 1
PTK2 -0.006 0.086 0.55 12 -10000 0 12
MAP4K4 -0.027 0.053 0.24 17 -10000 0 17
SRC 0.031 0.008 -10000 0 -10000 0 0
KALRN 0.032 0.005 -10000 0 -10000 0 0
Intersectin/N-WASP 0.033 0.022 -10000 0 -10000 0 0
neuron projection morphogenesis 0.059 0.16 0.33 128 -0.17 2 130
MAP2K1 0.004 0.035 -10000 0 -0.2 4 4
WASL 0.023 0.015 -10000 0 -10000 0 0
Ephrin B1/EPHB1-2/NCK1 0.072 0.035 -10000 0 -10000 0 0
cell migration -0.001 0.055 0.17 10 -0.22 8 18
NRAS 0.009 0.041 -10000 0 -0.063 125 125
SYNJ1 -0.023 0.039 0.18 13 -10000 0 13
PXN 0.032 0.003 -10000 0 -10000 0 0
TF -0.016 0.034 0.18 8 -10000 0 8
HRAS/GTP 0.046 0.04 -10000 0 -10000 0 0
Ephrin B1/EPHB1-2 0.057 0.023 -10000 0 -0.036 22 22
cell adhesion mediated by integrin 0.014 0.039 -10000 0 -0.2 9 9
RAC1 0.023 0.015 -10000 0 -10000 0 0
mol:GTP 0.051 0.039 0.14 5 -10000 0 5
RAC1-CDC42/GTP -0.034 0.028 -10000 0 -10000 0 0
RASA1 0.032 0.006 -10000 0 -10000 0 0
RAC1-CDC42/GDP 0.019 0.065 0.21 30 -0.16 22 52
ruffle organization 0.066 0.16 0.32 130 -10000 0 130
NCK1 0.03 0.015 -10000 0 -0.063 11 11
receptor internalization -0.005 0.024 0.22 3 -10000 0 3
Ephrin B/EPHB2/KALRN 0.077 0.045 -10000 0 -10000 0 0
ROCK1 -0.015 0.04 0.18 21 -10000 0 21
RAS family/GDP -0.035 0.034 -10000 0 -0.13 24 24
Rac1/GTP -0.029 0.026 0.047 4 -10000 0 4
Ephrin B/EPHB1/Src/Paxillin 0.015 0.037 -10000 0 -0.12 32 32
Lissencephaly gene (LIS1) in neuronal migration and development

Figure S83.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S83.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
DYNC1H1 0.03 0.009 -10000 0 -10000 0 0
VLDLR 0.029 0.012 -10000 0 -0.063 3 3
LRPAP1 0.032 0.003 -10000 0 -10000 0 0
NUDC 0.032 0.006 -10000 0 -10000 0 0
RELN/LRP8 0.02 0.031 -10000 0 -0.048 2 2
CaM/Ca2+ 0.021 0.008 -10000 0 -10000 0 0
KATNA1 0.029 0.012 -10000 0 -0.063 5 5
GO:0030286 0 0 -10000 0 -10000 0 0
ABL1 0.012 0.063 0.18 63 -10000 0 63
IQGAP1/CaM 0.021 0.04 -10000 0 -0.05 111 111
DAB1 0.032 0.005 -10000 0 -10000 0 0
IQGAP1 0.01 0.04 -10000 0 -0.063 120 120
PLA2G7 0.031 0.012 -10000 0 -0.063 8 8
CALM1 0.029 0.01 -10000 0 -10000 0 0
DYNLT1 0.017 0.033 -10000 0 -0.063 72 72
mol:Ca2+ 0 0 -10000 0 -10000 0 0
LRPAP1/LRP8 0.047 0.009 -10000 0 -10000 0 0
UniProt:Q4QZ09 0 0 -10000 0 -10000 0 0
CLIP1 0.032 0.003 -10000 0 -10000 0 0
CDK5R1 0.026 0.013 -10000 0 -10000 0 0
LIS1/Poliovirus Protein 3A -0.016 0.005 -10000 0 -10000 0 0
CDK5R2 0.012 0.016 -10000 0 -10000 0 0
mol:PP1 0 0 -10000 0 -10000 0 0
RELN/VLDLR/DAB1 0.019 0.032 -10000 0 -0.048 3 3
YWHAE 0.032 0.005 -10000 0 -10000 0 0
NDEL1/14-3-3 E 0.025 0.095 0.3 49 -10000 0 49
MAP1B 0.005 0.002 -10000 0 -10000 0 0
RAC1 0.002 0.016 -10000 0 -0.25 1 1
p35/CDK5 0.009 0.044 0.17 5 -10000 0 5
RELN 0.01 0.016 -10000 0 -0.063 2 2
PAFAH/LIS1 0.025 0.015 -10000 0 -0.042 16 16
LIS1/CLIP170 0.026 0.012 -10000 0 -0.035 10 10
LIS1/NDEL1/Katanin 60/Dynein Light chain/Dynein heavy chain -0.006 0.039 0.13 4 -10000 0 4
RELN/VLDLR/DAB1/LIS1/PAFAH1B2/PAFAH1B3 -0.001 0.046 0.13 4 -0.21 21 25
GO:0005869 0 0 -10000 0 -10000 0 0
NDEL1 0.019 0.074 0.3 29 -10000 0 29
LIS1/IQGAP1 0.009 0.033 -10000 0 -0.047 124 124
RHOA 0 0.031 -10000 0 -0.26 6 6
PAFAH1B1 -0.02 0.007 -10000 0 -10000 0 0
PAFAH1B3 0.031 0.007 -10000 0 -10000 0 0
PAFAH1B2 0.032 0.004 -10000 0 -10000 0 0
MAP1B/LIS1/Dynein heavy chain 0.02 0.027 0.11 1 -0.15 5 6
NDEL1/Katanin 60/Dynein heavy chain 0.027 0.095 0.3 45 -10000 0 45
LRP8 0.032 0.005 -10000 0 -10000 0 0
NDEL1/Katanin 60 0.022 0.091 0.29 44 -10000 0 44
P39/CDK5 0.003 0.03 0.17 3 -10000 0 3
LIS1/NudC/Dynein intermediate chain/microtubule organizing center 0.026 0.012 -10000 0 -0.035 9 9
CDK5 0.011 0.043 0.18 10 -10000 0 10
PPP2R5D 0.032 0.004 -10000 0 -10000 0 0
LIS1/CLIP170/Dynein Complex/Dynactin Complex 0.023 0.01 -10000 0 -0.029 10 10
CSNK2A1 0.03 0.008 -10000 0 -10000 0 0
RELN/VLDLR/DAB1/LIS1 0.019 0.035 0.17 5 -10000 0 5
RELN/VLDLR 0.024 0.04 -10000 0 -10000 0 0
CDC42 -0.001 0.033 -10000 0 -0.26 7 7
Thromboxane A2 receptor signaling

Figure S84.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S84.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGM2 0.03 0.011 -10000 0 -0.063 3 3
GNB1/GNG2 -0.031 0.026 -10000 0 -0.12 12 12
AKT1 -0.006 0.084 0.23 15 -0.26 28 43
EGF 0.032 0.007 -10000 0 -0.063 2 2
mol:TXA2 0 0 -10000 0 -10000 0 0
FGR -0.022 0.062 0.28 16 -0.15 4 20
mol:Ca2+ -0.008 0.075 0.26 10 -0.27 15 25
LYN -0.024 0.065 0.28 18 -0.16 4 22
RhoA/GTP -0.006 0.036 -10000 0 -0.11 7 7
mol:PGI2 0 0 -10000 0 -10000 0 0
SYK -0.018 0.079 0.29 12 -0.26 12 24
GNG2 0 0 -10000 0 -10000 0 0
ARRB2 0.032 0.005 -10000 0 -10000 0 0
TP alpha/Gq family/GDP/G beta5/gamma2 0.007 0.051 0.14 7 -0.22 15 22
G beta5/gamma2 -0.035 0.036 -10000 0 -0.15 7 7
PRKCH -0.014 0.077 0.27 9 -0.28 14 23
DNM1 0.006 0.012 -10000 0 -10000 0 0
TXA2/TP beta/beta Arrestin3 0.002 0.008 -10000 0 -10000 0 0
mol:GTP 0 0.001 0.004 14 -0.002 14 28
PTGDR 0.031 0.008 -10000 0 0 29 29
G12 family/GTP -0.023 0.05 -10000 0 -0.25 7 7
ADRBK1 0.032 0.004 -10000 0 -10000 0 0
ADRBK2 0.031 0.008 -10000 0 -10000 0 0
RhoA/GTP/ROCK1 0.042 0.01 -10000 0 -10000 0 0
mol:GDP 0.004 0.082 0.28 22 -0.27 9 31
mol:NADP 0.022 0.015 -10000 0 -10000 0 0
RAB11A 0.032 0.005 -10000 0 -10000 0 0
PRKG1 0.025 0.014 -10000 0 -10000 0 0
mol:IP3 -0.011 0.087 0.29 9 -0.33 15 24
cell morphogenesis 0.041 0.01 -10000 0 -10000 0 0
PLCB2 -0.017 0.1 0.34 6 -0.44 15 21
mol:cGMP 0 0 -10000 0 -10000 0 0
BLK -0.021 0.064 0.28 18 -0.15 4 22
mol:PDG2 0 0 -10000 0 -10000 0 0
HCK -0.029 0.045 0.24 9 -0.16 3 12
RHOA 0.032 0.006 -10000 0 -10000 0 0
PTGIR 0.031 0.007 -10000 0 -10000 0 0
PRKCB1 -0.014 0.079 0.27 8 -0.3 14 22
GNAQ 0.031 0.006 -10000 0 -10000 0 0
mol:L-citrulline 0.022 0.015 -10000 0 -10000 0 0
TXA2/TXA2-R family -0.024 0.095 0.33 6 -0.37 14 20
LCK -0.022 0.064 0.28 17 -0.15 4 21
TXA2/TP beta/beta Arrestin3/RAB11/GDP 0.027 0.038 0.19 2 -0.1 27 29
TXA2-R family/G12 family/GDP/G beta/gamma 0.003 0.087 -10000 0 -0.42 20 20
TXA2/TP beta/beta Arrestin2/RAB11/GDP 0.026 0.039 0.17 3 -0.1 28 31
MAPK14 -0.016 0.061 0.24 12 -0.18 12 24
TGM2/GTP -0.011 0.092 0.33 5 -0.36 14 19
MAPK11 -0.015 0.06 0.25 10 -0.19 12 22
ARHGEF1 -0.018 0.032 -10000 0 -0.15 7 7
GNAI2 0.032 0.006 -10000 0 -10000 0 0
JNK cascade -0.017 0.08 0.28 10 -0.28 14 24
RAB11/GDP 0.031 0.009 -10000 0 -0.03 8 8
ICAM1 -0.014 0.062 0.22 11 -0.2 16 27
cAMP biosynthetic process -0.012 0.083 0.28 10 -0.3 16 26
Gq family/GTP/EBP50 0.013 0.041 0.22 9 -0.2 8 17
actin cytoskeleton reorganization 0.041 0.01 -10000 0 -10000 0 0
SRC -0.027 0.045 0.24 9 -0.15 4 13
GNB5 0.031 0.006 -10000 0 -10000 0 0
GNB1 0.031 0.008 -10000 0 -10000 0 0
EGF/EGFR 0.01 0.077 0.25 28 -0.16 10 38
VCAM1 -0.02 0.065 0.23 10 -0.21 15 25
TP beta/Gq family/GDP/G beta5/gamma2 0.007 0.051 0.14 7 -0.22 15 22
platelet activation -0.018 0.078 0.3 12 -0.25 13 25
PGI2/IP 0.023 0.005 -10000 0 0 27 27
PRKACA 0.009 0.029 -10000 0 -0.09 38 38
Gq family/GDP/G beta5/gamma2 0.01 0.045 0.14 8 -0.2 16 24
TXA2/TP beta/beta Arrestin2 -0.007 0.057 -10000 0 -0.33 14 14
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
TBXA2R -0.015 0.024 -10000 0 -0.095 39 39
mol:DAG -0.014 0.088 0.3 8 -0.34 14 22
EGFR 0.012 0.018 -10000 0 -0.063 6 6
TXA2/TP alpha -0.016 0.1 0.33 9 -0.4 15 24
Gq family/GTP 0.008 0.026 0.21 6 -0.21 2 8
YES1 -0.025 0.058 0.27 14 -0.16 4 18
GNAI2/GTP 0.016 0.038 -10000 0 -0.1 36 36
PGD2/DP 0.023 0.006 -10000 0 0 29 29
SLC9A3R1 0.032 0.007 -10000 0 -0.063 2 2
FYN -0.018 0.064 0.28 18 -0.15 4 22
mol:NO 0.022 0.015 -10000 0 -10000 0 0
GNA15 0.03 0.013 -10000 0 -0.016 27 27
PGK/cGMP 0.026 0.022 -10000 0 -10000 0 0
RhoA/GDP 0.031 0.009 -10000 0 -0.03 7 7
TP alpha/TGM2/GDP/G beta/gamma 0.026 0.038 0.15 2 -0.1 27 29
NOS3 0.022 0.015 -10000 0 -10000 0 0
RAC1 0.023 0.015 -10000 0 -10000 0 0
PRKCA -0.014 0.077 0.25 12 -0.28 14 26
PRKCB -0.012 0.075 0.26 9 -0.27 14 23
PRKCE -0.015 0.076 0.26 10 -0.28 13 23
PRKCD -0.017 0.078 0.26 11 -0.28 14 25
PRKCG -0.015 0.082 0.29 10 -0.31 14 24
muscle contraction -0.025 0.094 0.33 7 -0.36 14 21
PRKCZ -0.016 0.073 0.26 10 -0.26 14 24
ARR3 0.032 0.002 -10000 0 -10000 0 0
TXA2/TP beta 0.027 0.041 0.15 2 -0.1 38 40
PRKCQ -0.018 0.07 0.29 6 -0.28 14 20
MAPKKK cascade -0.019 0.092 0.3 8 -0.37 14 22
SELE -0.014 0.063 0.23 10 -0.21 14 24
TP beta/GNAI2/GDP/G beta/gamma 0.028 0.039 0.16 3 -0.1 25 28
ROCK1 0.032 0.005 -10000 0 -10000 0 0
GNA14 0.031 0.009 -10000 0 -0.063 2 2
chemotaxis -0.029 0.095 0.33 6 -0.37 12 18
GNA12 0.023 0.015 -10000 0 -10000 0 0
GNA13 0.032 0.007 -10000 0 -0.063 2 2
GNA11 0.031 0.006 -10000 0 -10000 0 0
Rac1/GTP 0.017 0.011 -10000 0 -10000 0 0
p75(NTR)-mediated signaling

Figure S85.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S85.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Sortilin/TRAF6 0.046 0.01 -10000 0 -10000 0 0
Necdin/E2F1 0.028 0.024 -10000 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/NADE/14-3-3 E 0.068 0.032 -10000 0 -10000 0 0
NGF (dimer)/p75(NTR)/BEX1 0.028 0.024 -10000 0 -0.04 16 16
NT-4/5 (dimer)/p75(NTR) 0.021 0.013 -10000 0 -0.039 21 21
IKBKB 0.032 0.003 -10000 0 -10000 0 0
AKT1 -0.014 0.046 0.18 21 -10000 0 21
IKBKG 0.032 0.003 -10000 0 -10000 0 0
BDNF 0.009 0.015 -10000 0 -10000 0 0
MGDIs/NGR/p75(NTR)/LINGO1 0.02 0.011 -10000 0 -0.031 21 21
FURIN 0.032 0.004 -10000 0 -10000 0 0
proBDNF (dimer)/p75(NTR)/Sortilin 0.017 0.03 -10000 0 -0.048 8 8
LINGO1 0 0 -10000 0 -10000 0 0
Sortilin/TRAF6/NRIF -0.049 0.015 -10000 0 -10000 0 0
proBDNF (dimer) 0.009 0.015 -10000 0 -10000 0 0
NTRK1 0.032 0.006 -10000 0 -0.063 1 1
RTN4R 0 0 -10000 0 -10000 0 0
neuron apoptosis 0.023 0.079 0.22 7 -0.3 19 26
IRAK1 0.032 0.003 -10000 0 -10000 0 0
SHC1 -0.02 0.008 -10000 0 -0.04 59 59
ARHGDIA 0.032 0.003 -10000 0 -10000 0 0
RhoA/GTP 0.023 0.004 -10000 0 -10000 0 0
Gamma Secretase 0.072 0.053 -10000 0 -0.078 1 1
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-H1 0.052 0.027 -10000 0 -0.043 18 18
MAGEH1 0.03 0.009 -10000 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/Necdin 0.034 0.034 -10000 0 -0.043 14 14
Mammalian IAPs/DIABLO 0.054 0.028 -10000 0 -0.042 37 37
proNGF (dimer) 0 0 -10000 0 -10000 0 0
MAGED1 0.032 0.003 -10000 0 -10000 0 0
APP 0.032 0.005 -10000 0 -10000 0 0
NT-4/5 (dimer) 0 0 -10000 0 -10000 0 0
ZNF274 0.03 0.011 -10000 0 -0.063 3 3
RhoA/GDP/RHOGDI 0.037 0.018 -10000 0 -0.039 22 22
NGF 0 0 -10000 0 -10000 0 0
cell cycle arrest -0.017 0.027 0.2 6 -10000 0 6
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK 0.011 0.028 -10000 0 -0.11 15 15
NT-4/5 (dimer)/p75(NTR)/TRAF6 0.039 0.018 -10000 0 -0.04 21 21
NCSTN 0.027 0.022 -10000 0 -0.063 28 28
mol:GTP 0.035 0.021 -10000 0 -0.04 20 20
PSENEN 0.031 0.007 -10000 0 -10000 0 0
mol:ceramide -0.02 0.025 0.18 7 -10000 0 7
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs 0.011 0.023 -10000 0 -0.1 16 16
p75(NTR)/beta APP 0.043 0.021 -10000 0 -0.05 20 20
BEX1 0.023 0.015 -10000 0 -10000 0 0
mol:GDP -0.01 0.004 -10000 0 -10000 0 0
NGF (dimer) 0.039 0.043 -10000 0 -0.039 119 119
MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI 0.038 0.016 -10000 0 -0.034 22 22
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
RAC1/GTP 0.024 0.021 -10000 0 -0.031 21 21
MYD88 0.019 0.032 -10000 0 -0.063 67 67
CHUK 0.024 0.015 -10000 0 -0.063 1 1
NGF (dimer)/p75(NTR)/PKA 0.036 0.021 -10000 0 -0.04 20 20
RHOB 0.03 0.011 -10000 0 -0.063 4 4
RHOA 0.032 0.006 -10000 0 -10000 0 0
MAGE-G1/E2F1 0.022 0.006 -10000 0 -10000 0 0
NT3 (dimer) 0.031 0.007 -10000 0 -10000 0 0
TP53 0.033 0.064 0.23 25 -10000 0 25
PRDM4 -0.021 0.024 0.18 7 -10000 0 7
BDNF (dimer) 0.014 0.038 -10000 0 -0.066 4 4
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
SORT1 0.032 0.004 -10000 0 -10000 0 0
activation of caspase activity 0.061 0.03 -10000 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 0.055 0.027 -10000 0 -0.043 20 20
RHOC 0.003 0.044 -10000 0 -0.063 155 155
XIAP 0 0 -10000 0 -10000 0 0
MAPK10 0.038 0.074 0.19 80 -0.13 1 81
DIABLO 0.032 0.004 -10000 0 -10000 0 0
SMPD2 -0.02 0.025 0.18 7 -10000 0 7
APH1B 0.032 0.005 -10000 0 -10000 0 0
APH1A 0.031 0.012 -10000 0 -0.063 7 7
proNGF (dimer)/p75(NTR)/Sortilin 0.04 0.018 -10000 0 -0.04 20 20
PSEN1 0.03 0.008 -10000 0 -10000 0 0
APAF-1/Pro-Caspase 9 0.046 0.012 -10000 0 -0.05 3 3
NT3 (dimer)/p75(NTR) 0.042 0.021 -10000 0 -0.05 20 20
MAPK8 0.035 0.066 0.18 69 -0.13 2 71
MAPK9 0.065 0.087 0.19 138 -10000 0 138
APAF1 0.032 0.004 -10000 0 -10000 0 0
NTF3 0.031 0.007 -10000 0 -10000 0 0
NTF4 0 0 -10000 0 -10000 0 0
NDN 0.02 0.016 -10000 0 -10000 0 0
RAC1/GDP 0.017 0.011 -10000 0 -10000 0 0
RhoA-B-C/GDP 0.023 0.056 -10000 0 -0.065 10 10
p75 CTF/Sortilin/TRAF6/NRIF 0.071 0.036 -10000 0 -10000 0 0
RhoA-B-C/GTP 0.035 0.021 -10000 0 -0.04 20 20
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.023 0.043 -10000 0 -10000 0 0
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 0.021 0.038 -10000 0 -10000 0 0
PRKACB 0.029 0.01 -10000 0 -10000 0 0
proBDNF (dimer)/p75 ECD 0.013 0.022 -10000 0 -0.05 3 3
ChemicalAbstracts:86-01-1 0 0 -10000 0 -10000 0 0
BIRC3 0.026 0.023 -10000 0 -0.063 30 30
BIRC2 0.032 0.004 -10000 0 -10000 0 0
neuron projection morphogenesis -0.008 0.023 -10000 0 -0.12 2 2
BAD 0.048 0.082 0.2 81 -0.16 3 84
RIPK2 0.032 0.006 -10000 0 -0.063 1 1
NGFR 0.028 0.019 -10000 0 -0.063 21 21
CYCS -0.018 0.022 0.17 4 -10000 0 4
ADAM17 0.031 0.01 -10000 0 -0.063 5 5
NGF (dimer)/p75(NTR)/TRAF6/RIP2 0.055 0.026 -10000 0 -0.042 22 22
BCL2L11 0.048 0.083 0.2 81 -0.16 3 84
BDNF (dimer)/p75(NTR) 0.012 0.023 -10000 0 -0.05 9 9
PI3K 0.048 0.033 -10000 0 -0.044 32 32
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-G1 0.037 0.017 -10000 0 -0.033 25 25
NDNL2 0 0 -10000 0 -10000 0 0
YWHAE 0.032 0.005 -10000 0 -10000 0 0
PRKCI 0.032 0.006 -10000 0 -0.063 1 1
NGF (dimer)/p75(NTR) 0.021 0.013 -10000 0 -0.039 21 21
ChemicalAbstracts:146-91-8 0 0 -10000 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/NRAGE 0.056 0.024 -10000 0 -0.043 20 20
TRAF6 0.032 0.005 -10000 0 -10000 0 0
RAC1 0.023 0.015 -10000 0 -10000 0 0
PRKCZ 0 0 -10000 0 -10000 0 0
PLG 0.03 0.008 -10000 0 -10000 0 0
oligodendrocyte cell fate commitment 0 0 -10000 0 -10000 0 0
CASP6 -0.005 0.012 0.14 1 -0.075 1 2
SQSTM1 0.032 0.006 -10000 0 -0.063 1 1
NGFRAP1 0.032 0.004 -10000 0 -10000 0 0
CASP3 0.046 0.081 0.19 78 -0.17 3 81
E2F1 0.03 0.008 -10000 0 -10000 0 0
CASP9 0.031 0.009 -10000 0 -0.063 3 3
IKK complex 0.037 0.049 -10000 0 -0.15 5 5
NGF (dimer)/TRKA 0.023 0.004 -10000 0 -0.039 1 1
MMP7 0.018 0.034 -10000 0 -0.063 75 75
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.062 0.038 -10000 0 -0.054 1 1
MMP3 0.031 0.012 -10000 0 -0.063 7 7
APAF-1/Caspase 9 -0.036 0.026 -10000 0 -10000 0 0
Insulin-mediated glucose transport

Figure S86.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S86.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Insulin responsive Vesicles -0.01 0.082 -10000 0 -0.23 42 42
CaM/Ca2+ 0.021 0.008 -10000 0 -10000 0 0
AKT1 0.03 0.008 -10000 0 -10000 0 0
AKT2 0.031 0.006 -10000 0 -10000 0 0
STXBP4 0 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
mol:glucose -0.027 0.077 0.21 1 -0.24 45 46
YWHAZ 0.032 0.006 -10000 0 -10000 0 0
CALM1 0.029 0.01 -10000 0 -10000 0 0
YWHAQ 0.032 0.004 -10000 0 -10000 0 0
TBC1D4 -0.02 0.007 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
YWHAH 0.015 0.016 -10000 0 0 279 279
YWHAB 0.03 0.009 -10000 0 -10000 0 0
SNARE/Synip 0.039 0.014 -10000 0 -10000 0 0
YWHAG 0 0 -10000 0 -10000 0 0
ASIP 0.03 0.008 -10000 0 -10000 0 0
PRKCI 0.032 0.006 -10000 0 -0.063 1 1
AS160/CaM/Ca2+ 0.021 0.008 -10000 0 -10000 0 0
RHOQ 0.032 0.002 -10000 0 -10000 0 0
GYS1 -0.006 0.006 -10000 0 -10000 0 0
PRKCZ 0 0 -10000 0 -10000 0 0
TRIP10 0.031 0.012 -10000 0 -0.063 6 6
TC10/GTP/CIP4/Exocyst 0.042 0.012 -10000 0 -0.04 6 6
AS160/14-3-3 -0.021 0.045 0.1 1 -0.17 18 19
VAMP2 0.029 0.011 -10000 0 -10000 0 0
SLC2A4 -0.03 0.085 0.21 1 -0.26 45 46
STX4 0.032 0.002 -10000 0 -10000 0 0
GSK3B 0.017 0.006 -10000 0 -10000 0 0
SFN 0.026 0.023 -10000 0 -0.063 31 31
LNPEP 0.032 0.006 -10000 0 -0.063 1 1
YWHAE 0.032 0.005 -10000 0 -10000 0 0
IL6-mediated signaling events

Figure S87.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S87.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 0.059 0.13 0.4 31 -10000 0 31
CRP 0.05 0.12 0.47 11 -10000 0 11
cell cycle arrest 0.052 0.12 0.36 18 -10000 0 18
TIMP1 0.016 0.11 0.39 7 -0.53 1 8
IL6ST 0.031 0.011 -10000 0 -10000 0 0
Rac1/GDP 0.019 0.056 0.22 10 -0.22 3 13
AP1 0.033 0.064 -10000 0 -0.35 5 5
GAB2 0.032 0.007 -10000 0 -0.026 1 1
TNFSF11 0.046 0.11 0.43 8 -10000 0 8
HSP90B1 0.043 0.051 -10000 0 -0.49 2 2
GAB1 0.032 0.009 -10000 0 -0.054 4 4
MAPK14 0.011 0.045 0.18 2 -0.21 3 5
AKT1 0.022 0.041 0.23 1 -0.45 2 3
FOXO1 0.016 0.043 0.2 4 -0.44 2 6
MAP2K6 0.008 0.039 0.11 25 -0.22 3 28
mol:GTP 0 0.001 -10000 0 -10000 0 0
MAP2K4 0.009 0.062 0.26 11 -0.26 1 12
MITF 0.007 0.039 0.11 30 -0.21 2 32
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
TYK2 0.031 0.007 -10000 0 -10000 0 0
A2M -0.021 0.18 -10000 0 -0.94 18 18
CEBPB 0.03 0.017 -10000 0 -0.059 12 12
GRB2/SOS1/GAB family/SHP2 0.022 0.044 0.23 1 -0.27 4 5
STAT3 0.051 0.12 0.38 15 -10000 0 15
STAT1 0.017 0.023 -10000 0 -10000 0 0
CEBPD 0.048 0.11 0.41 11 -10000 0 11
PIK3CA 0.028 0.018 -10000 0 -0.061 18 18
PI3K 0.04 0.023 -10000 0 -0.049 17 17
JUN 0.032 0.005 -10000 0 -10000 0 0
PIAS3/MITF 0.055 0.076 0.19 75 -0.21 2 77
MAPK11 0.008 0.043 0.18 2 -0.21 3 5
STAT3 (dimer)/FOXO1 -0.004 0.066 0.27 1 -0.4 1 2
GRB2/SOS1/GAB family 0.058 0.058 0.17 6 -0.21 3 9
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/HCK 0.004 0.033 -10000 0 -0.2 4 4
GRB2 0.032 0.006 -10000 0 -0.027 1 1
JAK2 0.029 0.01 -10000 0 -10000 0 0
LBP 0.061 0.12 0.38 21 -0.62 1 22
PIK3R1 0.03 0.01 -10000 0 -0.026 1 1
JAK1 0.032 0.007 -10000 0 -10000 0 0
MYC 0.042 0.12 0.4 14 -10000 0 14
FGG 0.046 0.11 0.4 10 -10000 0 10
macrophage differentiation 0.052 0.12 0.36 18 -10000 0 18
IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 0.046 0.059 -10000 0 -10000 0 0
JUNB 0.05 0.12 0.4 21 -10000 0 21
FOS 0.007 0.04 -10000 0 -0.063 120 120
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 0.013 0.041 0.12 24 -0.23 3 27
STAT1/PIAS1 0.041 0.064 0.2 17 -10000 0 17
GRB2/SOS1/GAB family/SHP2/PI3K 0.032 0.04 -10000 0 -0.47 2 2
STAT3 (dimer) 0.052 0.12 0.37 16 -10000 0 16
PRKCD 0.071 0.15 0.3 126 -10000 0 126
IL6R 0.032 0.006 -10000 0 -10000 0 0
SOCS3 0.049 0.084 0.37 10 -10000 0 10
gp130 (dimer)/JAK1/JAK1/LMO4 0.061 0.023 -10000 0 -10000 0 0
Rac1/GTP 0.014 0.051 0.19 3 -0.22 3 6
HCK 0.014 0.036 -10000 0 -0.063 85 85
MAPKKK cascade 0.042 0.059 0.27 2 -0.36 6 8
bone resorption 0.046 0.11 0.42 8 -10000 0 8
IRF1 0.043 0.12 0.42 9 -10000 0 9
mol:GDP 0.005 0.04 0.11 22 -0.22 3 25
SOS1 0 0.002 -10000 0 -10000 0 0
VAV1 0.005 0.04 0.11 22 -0.22 3 25
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 0.019 0.046 0.19 2 -0.28 6 8
PTPN11 0.018 0.044 -10000 0 -0.63 2 2
IL6/IL6RA 0.026 0.031 -10000 0 -0.059 1 1
gp130 (dimer)/TYK2/TYK2/LMO4 0.059 0.022 -10000 0 -10000 0 0
gp130 (dimer)/JAK2/JAK2/LMO4 0.054 0.03 -10000 0 -0.05 1 1
IL6 0.015 0.027 -10000 0 -0.065 37 37
PIAS3 0.032 0.004 -10000 0 0 7 7
PTPRE 0.023 0.015 -10000 0 -10000 0 0
PIAS1 0.032 0.004 -10000 0 0 9 9
RAC1 0.023 0.015 -10000 0 -10000 0 0
IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 0.016 0.036 0.11 43 -0.11 6 49
LMO4 0.03 0.011 -10000 0 -10000 0 0
STAT3 (dimer)/PIAS3 0.023 0.077 0.29 1 -10000 0 1
MCL1 0.021 0.049 0.25 3 -0.41 2 5
Sumoylation by RanBP2 regulates transcriptional repression

Figure S88.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S88.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.02 0.031 -9999 0 -0.063 61 61
Ran/GTP/Exportin 1/HDAC4 -0.027 0.011 -9999 0 -0.062 39 39
MDM2/SUMO1 0.034 0.039 -9999 0 -0.098 36 36
HDAC4 0.032 0.003 -9999 0 -10000 0 0
Ran/GTP/Exportin 1/HDAC1 -0.029 0.012 -9999 0 -0.066 38 38
SUMO1 0.033 0.001 -9999 0 -10000 0 0
NPC/RanGAP1/SUMO1 0.01 0.003 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
XPO1 -0.005 0.026 -9999 0 -0.096 39 39
EntrezGene:23636 0 0 -9999 0 -10000 0 0
RAN 0.032 0.004 -9999 0 -10000 0 0
EntrezGene:8021 0 0 -9999 0 -10000 0 0
RANBP2 0.032 0.002 -9999 0 -10000 0 0
SUMO1/HDAC4 0.038 0.039 -9999 0 -0.097 39 39
SUMO1/HDAC1 0.03 0.043 -9999 0 -0.1 38 38
RANGAP1 0.03 0.008 -9999 0 -10000 0 0
MDM2/SUMO1/SUMO1 0.07 0.034 -9999 0 -0.05 1 1
NPC/RanGAP1/SUMO1/RanBP2/Ubc9 0.003 0.028 -9999 0 -0.095 39 39
Ran/GTP 0.021 0.033 -9999 0 -0.092 39 39
EntrezGene:23225 0 0 -9999 0 -10000 0 0
MDM2 0.029 0.011 -9999 0 -0.063 1 1
UBE2I 0.032 0.003 -9999 0 -10000 0 0
Ran/GTP/Exportin 1 0.015 0.032 -9999 0 -10000 0 0
NPC 0.019 0.001 -9999 0 -10000 0 0
PIAS2 0.031 0.006 -9999 0 -10000 0 0
PIAS1 0.032 0.004 -9999 0 0 9 9
EntrezGene:9972 0 0 -9999 0 -10000 0 0
E-cadherin signaling events

Figure S89.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S89.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
E-cadherin/beta catenin-gamma catenin 0.057 0.03 -9999 0 -0.045 38 38
E-cadherin/beta catenin 0.045 0.016 -9999 0 -0.05 8 8
CTNNB1 0.032 0.005 -9999 0 -10000 0 0
JUP 0.029 0.017 -9999 0 -0.063 16 16
CDH1 0.03 0.013 -9999 0 -0.063 8 8
Canonical NF-kappaB pathway

Figure S90.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S90.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
FBXW11 0.032 0.005 -10000 0 -0.033 1 1
mol:GTP 0 0 -10000 0 -10000 0 0
NF kappa B1 p50/RelA/I kappa B alpha 0.007 0.074 0.22 7 -0.25 16 23
ERC1 0.031 0.006 -10000 0 -10000 0 0
RIP2/NOD2 0.045 0.015 -10000 0 -0.05 9 9
NFKBIA -0.028 0.017 0.2 2 -10000 0 2
BIRC2 0.032 0.004 -10000 0 -10000 0 0
IKBKB 0.032 0.003 -10000 0 -10000 0 0
RIPK2 0.032 0.006 -10000 0 -0.063 1 1
IKBKG 0.018 0.051 -10000 0 -0.28 10 10
IKK complex/A20 0.035 0.068 -10000 0 -0.37 6 6
NEMO/A20/RIP2 0.032 0.006 -10000 0 -0.063 1 1
XPO1 0.033 0.001 -10000 0 -10000 0 0
NEMO/ATM 0.035 0.055 0.19 1 -0.38 6 7
tumor necrosis factor receptor activity 0 0 -10000 0 -10000 0 0
RAN 0.032 0.004 -10000 0 -10000 0 0
Exportin 1/RanGTP 0.043 0.006 -10000 0 -10000 0 0
IKK complex/ELKS 0.039 0.059 -10000 0 -0.36 6 6
BCL10/MALT1/TRAF6 0.054 0.033 -10000 0 -0.042 47 47
NOD2 0.031 0.013 -10000 0 -0.063 8 8
NFKB1 0.031 0.01 -10000 0 -0.058 5 5
RELA 0.032 0.005 -10000 0 -0.033 1 1
MALT1 0.028 0.02 -10000 0 -0.063 21 21
cIAP1/UbcH5C 0.047 0.009 -10000 0 -10000 0 0
ATM 0.027 0.021 -10000 0 -0.063 25 25
TNF/TNFR1A 0.014 0.045 -10000 0 -0.05 166 166
TRAF6 0.032 0.005 -10000 0 -10000 0 0
PRKCA 0.032 0.004 -10000 0 -10000 0 0
CHUK 0.024 0.015 -10000 0 -0.063 1 1
UBE2D3 0.032 0.005 -10000 0 -10000 0 0
TNF 0.032 0.006 -10000 0 -0.063 2 2
NF kappa B1 p50/RelA 0.065 0.025 -10000 0 -0.055 5 5
BCL10 0.031 0.009 -10000 0 -0.063 3 3
proteasomal ubiquitin-dependent protein catabolic process -0.028 0.017 0.2 2 -10000 0 2
beta TrCP1/SCF ubiquitin ligase complex 0.032 0.005 -10000 0 -0.033 1 1
TNFRSF1A 0 0.044 -10000 0 -0.063 165 165
IKK complex 0.04 0.061 -10000 0 -0.38 6 6
CYLD 0.032 0.004 -10000 0 -10000 0 0
IKK complex/PKC alpha 0.049 0.066 -10000 0 -0.37 6 6
Hedgehog signaling events mediated by Gli proteins

Figure S91.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S91.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.02 0.031 -10000 0 -0.063 61 61
HDAC2 0.03 0.012 -10000 0 -0.063 4 4
GNB1/GNG2 0.028 0.021 -10000 0 -10000 0 0
forebrain development 0.026 0.055 0.22 14 -10000 0 14
GNAO1 0.003 0.009 -10000 0 -10000 0 0
SMO/beta Arrestin2 0.033 0.023 -10000 0 -10000 0 0
SMO 0.023 0.015 -10000 0 -10000 0 0
ARRB2 0.032 0.005 -10000 0 -10000 0 0
GLI3/SPOP 0.01 0.069 -10000 0 -0.21 19 19
mol:GTP 0 0 -10000 0 -10000 0 0
GSK3B 0.032 0.006 -10000 0 -10000 0 0
GNAI2 0.032 0.006 -10000 0 -0.026 1 1
SIN3/HDAC complex 0.053 0.028 -10000 0 -0.039 5 5
GNAI1 0.019 0.016 -10000 0 -0.063 1 1
XPO1 0.033 0.007 -10000 0 -0.027 6 6
GLI1/Su(fu) 0.005 0.025 -10000 0 -0.24 1 1
SAP30 0.032 0.006 -10000 0 -10000 0 0
mol:GDP 0.023 0.015 -10000 0 -10000 0 0
MIM/GLI2A 0.034 0.008 -10000 0 -0.04 3 3
IFT88 0.031 0.008 -10000 0 -10000 0 0
GNAI3 0.021 0.03 -10000 0 -0.063 58 58
GLI2 0.012 0.048 0.15 10 -0.22 9 19
GLI3 -0.005 0.062 -10000 0 -0.22 17 17
CSNK1D 0.032 0.007 -10000 0 -0.063 2 2
CSNK1E 0.03 0.008 -10000 0 -10000 0 0
SAP18 0.031 0.008 -10000 0 -10000 0 0
embryonic digit morphogenesis 0.031 0.008 -10000 0 -10000 0 0
GNG2 0 0 -10000 0 -10000 0 0
Gi family/GTP 0.001 0.01 0.089 1 -0.12 2 3
SIN3B 0.031 0.006 -10000 0 -10000 0 0
SIN3A 0 0 -10000 0 -10000 0 0
GLI3/Su(fu) -0.004 0.046 0.1 1 -0.18 19 20
GLI2/Su(fu) 0.006 0.035 0.12 3 -0.18 9 12
FOXA2 0.037 0.037 -10000 0 -0.47 2 2
neural tube patterning 0.026 0.055 0.22 14 -10000 0 14
SPOP 0.032 0.004 -10000 0 -10000 0 0
Su(fu)/PIAS1 0.044 0.034 0.093 151 -0.063 8 159
GNB1 0.031 0.008 -10000 0 -10000 0 0
CSNK1G2 0.031 0.006 -10000 0 -10000 0 0
CSNK1G3 0.032 0.004 -10000 0 -10000 0 0
MTSS1 0.034 0.008 -10000 0 -0.04 3 3
embryonic limb morphogenesis 0.026 0.055 0.22 14 -10000 0 14
SUFU -0.002 0.002 -10000 0 -10000 0 0
LGALS3 0.019 0.031 -10000 0 -0.063 60 60
catabolic process 0.026 0.077 0.19 6 -0.29 14 20
GLI3A/CBP 0.036 0.016 -10000 0 -0.083 8 8
KIF3A 0.029 0.01 -10000 0 -10000 0 0
GLI1 0.026 0.055 0.22 14 -10000 0 14
RAB23 0.031 0.01 -10000 0 -0.063 5 5
CSNK1A1 0.032 0.004 -10000 0 -10000 0 0
IFT172 0 0 -10000 0 -10000 0 0
RBBP7 0.032 0.002 -10000 0 -10000 0 0
Su(fu)/Galectin3 0.034 0.038 0.093 126 -0.062 6 132
GNAZ 0.027 0.013 -10000 0 -10000 0 0
RBBP4 0.015 0.036 -10000 0 -0.063 89 89
CSNK1G1 0.032 0.005 -10000 0 -10000 0 0
PIAS1 0.032 0.004 -10000 0 0 9 9
PRKACA 0.032 0.006 -10000 0 0 17 17
GLI2/SPOP 0.029 0.051 0.15 10 -0.22 9 19
STK36 0.001 0.001 -10000 0 -10000 0 0
Gi family/GNB1/GNG2/GDP 0 0.014 -10000 0 -0.16 3 3
PTCH1 0.024 0.064 0.35 7 -10000 0 7
MIM/GLI1 0.043 0.058 0.23 12 -10000 0 12
CREBBP 0.036 0.016 -10000 0 -0.083 8 8
Su(fu)/SIN3/HDAC complex 0.008 0.058 0.13 4 -0.18 31 35
Stabilization and expansion of the E-cadherin adherens junction

Figure S92.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S92.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
adherens junction organization -0.022 0.03 -10000 0 -0.13 24 24
epithelial cell differentiation 0.06 0.032 -10000 0 -10000 0 0
CYFIP2 0.018 0.016 -10000 0 -10000 0 0
ENAH -0.045 0.051 0.41 4 -10000 0 4
EGFR 0.012 0.018 -10000 0 -0.063 6 6
EPHA2 0.029 0.015 -10000 0 -0.063 12 12
MYO6 -0.029 0.03 0.16 11 -10000 0 11
CTNNB1 0.032 0.005 -10000 0 -10000 0 0
ABI1/Sra1/Nap1 0.024 0.039 -10000 0 -10000 0 0
AQP5 -0.014 0.045 0.16 6 -0.31 8 14
CTNND1 0.03 0.014 -10000 0 -0.063 10 10
mol:PI-4-5-P2 -0.029 0.026 0.16 8 -10000 0 8
regulation of calcium-dependent cell-cell adhesion -0.028 0.03 0.16 11 -10000 0 11
EGF 0.032 0.007 -10000 0 -0.063 2 2
NCKAP1 0.032 0.002 -10000 0 -10000 0 0
AQP3 -0.03 0.076 0.16 4 -0.32 31 35
cortical microtubule organization 0.06 0.032 -10000 0 -10000 0 0
GO:0000145 -0.028 0.024 0.15 8 -10000 0 8
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.066 0.034 -10000 0 -10000 0 0
MLLT4 0.03 0.008 -10000 0 -10000 0 0
ARF6/GDP -0.053 0.015 -10000 0 -0.098 2 2
ARF6 0.031 0.008 -10000 0 -10000 0 0
Ephrin A1/EPHA2/NCK1/GIT1 0.067 0.042 -10000 0 -0.072 7 7
mol:Ca2+ 0 0 -10000 0 -10000 0 0
VASP -0.017 0.022 0.16 2 -0.19 1 3
PVRL2 0.031 0.007 -10000 0 -10000 0 0
ZYX -0.025 0.026 0.16 5 -10000 0 5
ARF6/GTP 0.069 0.051 -10000 0 -0.073 7 7
CDH1 0.03 0.013 -10000 0 -0.063 8 8
EGFR/EGFR/EGF/EGF 0.019 0.035 -10000 0 -10000 0 0
RhoA/GDP 0.061 0.034 -10000 0 -10000 0 0
actin cytoskeleton organization -0.024 0.025 0.14 7 -10000 0 7
IGF-1R heterotetramer 0.032 0.004 -10000 0 -10000 0 0
GIT1 0.032 0.004 -10000 0 -10000 0 0
IGF1R 0.032 0.004 -10000 0 -10000 0 0
IGF1 0.032 0.009 -10000 0 -0.063 4 4
DIAPH1 -0.22 0.26 -10000 0 -0.49 135 135
Wnt receptor signaling pathway -0.06 0.032 -10000 0 -10000 0 0
RHOA 0.032 0.006 -10000 0 -10000 0 0
RhoA/GTP -0.053 0.015 -10000 0 -0.098 2 2
CTNNA1 0.032 0.004 -10000 0 -10000 0 0
VCL -0.024 0.026 0.14 7 -10000 0 7
EFNA1 0.028 0.019 -10000 0 -0.063 20 20
LPP -0.035 0.023 0.15 5 -10000 0 5
Ephrin A1/EPHA2 0.047 0.041 -10000 0 -0.072 7 7
SEC6/SEC8 -0.043 0.011 -10000 0 -10000 0 0
MGAT3 -0.028 0.03 0.16 11 -10000 0 11
HGF/MET 0.035 0.038 -10000 0 -0.072 1 1
HGF 0.022 0.016 -10000 0 -0.063 1 1
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.022 0.03 -10000 0 -0.13 24 24
actin cable formation -0.039 0.079 0.34 12 -0.23 10 22
KIAA1543 -0.024 0.023 0.15 9 -10000 0 9
KIFC3 -0.031 0.024 0.16 7 -10000 0 7
NCK1 0.03 0.015 -10000 0 -0.063 11 11
EXOC3 0.032 0.006 -10000 0 -10000 0 0
ACTN1 -0.03 0.027 0.16 8 -10000 0 8
NCK1/GIT1 0.044 0.017 -10000 0 -0.05 11 11
mol:GDP 0.06 0.032 -10000 0 -10000 0 0
EXOC4 0 0 -10000 0 -10000 0 0
STX4 -0.031 0.027 0.16 9 -10000 0 9
PIP5K1C -0.029 0.026 0.16 8 -10000 0 8
LIMA1 -0.048 0.034 -10000 0 -0.063 425 425
ABI1 0.025 0.014 -10000 0 -10000 0 0
ROCK1 -0.041 0.069 0.41 8 -10000 0 8
adherens junction assembly -0.023 0.045 0.23 6 -0.2 9 15
IGF-1R heterotetramer/IGF1 0.053 0.035 -10000 0 -0.072 2 2
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.043 0.015 -10000 0 -10000 0 0
MET 0.022 0.016 -10000 0 -0.063 2 2
PLEKHA7 -0.028 0.005 -10000 0 -10000 0 0
mol:GTP 0.065 0.041 -10000 0 -0.071 7 7
establishment of epithelial cell apical/basal polarity -0.04 0.041 -10000 0 -10000 0 0
cortical actin cytoskeleton stabilization -0.022 0.03 -10000 0 -0.13 24 24
regulation of cell-cell adhesion -0.024 0.025 0.14 7 -10000 0 7
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.022 0.03 -10000 0 -0.13 24 24
IL2 signaling events mediated by STAT5

Figure S93.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S93.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GAB2 0.032 0.006 -10000 0 -10000 0 0
ELF1 0.033 0.018 -10000 0 -0.064 11 11
CCNA2 0.007 0.042 -10000 0 -0.063 135 135
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
JAK3 0.032 0.006 -10000 0 -10000 0 0
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
JAK1 0.032 0.006 -10000 0 -10000 0 0
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K 0.009 0.057 0.16 1 -0.24 8 9
SHC1 0.024 0.026 -10000 0 -0.063 40 40
SP1 0.033 0.02 -10000 0 -0.072 14 14
IL2RA -0.014 0.012 -10000 0 -0.096 5 5
IL2RB 0.03 0.011 -10000 0 -0.063 4 4
SOS1 0 0 -10000 0 -10000 0 0
IL2RG 0.031 0.013 -10000 0 -0.063 9 9
G1/S transition of mitotic cell cycle 0.024 0.093 0.27 14 -0.32 17 31
PTPN11 0.033 0.003 -10000 0 -10000 0 0
CCND2 -0.018 0.011 -10000 0 -0.097 8 8
LCK 0.031 0.01 -10000 0 -0.063 4 4
GRB2 0.032 0.006 -10000 0 -10000 0 0
IL2 0.032 0.004 -10000 0 -10000 0 0
CDK6 0.022 0.015 -10000 0 -10000 0 0
CCND3 0.006 0.055 0.19 2 -0.26 4 6
Neurotrophic factor-mediated Trk receptor signaling

Figure S94.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S94.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CRKL 0.031 0.007 -10000 0 -10000 0 0
RAS family/GTP/Tiam1 0.004 0.035 -10000 0 -0.13 21 21
NT3 (dimer)/TRKC 0.044 0.013 -10000 0 -10000 0 0
NT3 (dimer)/TRKB 0.05 0.033 -10000 0 -0.049 18 18
SHC/Grb2/SOS1/GAB1/PI3K 0.013 0.024 -10000 0 -0.12 10 10
RAPGEF1 0.031 0.006 -10000 0 -10000 0 0
BDNF 0.009 0.015 -10000 0 -10000 0 0
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
DYNLT1 0.017 0.033 -10000 0 -0.063 72 72
NTRK1 0.032 0.006 -10000 0 -0.063 1 1
NTRK2 0.028 0.011 -10000 0 -10000 0 0
NTRK3 0.031 0.006 -10000 0 -10000 0 0
NT-4/5 (dimer)/TRKB 0.035 0.021 -10000 0 -0.04 18 18
neuron apoptosis 0.03 0.056 0.18 9 -10000 0 9
SHC 2-3/Grb2 -0.032 0.059 -10000 0 -0.2 9 9
SHC1 0.024 0.026 -10000 0 -0.063 40 40
SHC2 -0.033 0.045 -10000 0 -0.29 3 3
SHC3 -0.038 0.062 -10000 0 -0.3 16 16
STAT3 (dimer) 0.017 0.042 -10000 0 -0.068 98 98
NT3 (dimer)/TRKA 0.057 0.028 -10000 0 -0.05 20 20
RIN/GDP 0.005 0.045 0.18 8 -0.16 10 18
GIPC1 0.031 0.006 -10000 0 -10000 0 0
KRAS 0.031 0.008 -10000 0 -10000 0 0
DNAJA3 -0.008 0.018 0.074 15 -0.15 1 16
RIN/GTP 0.013 0.012 -10000 0 -0.039 2 2
CCND1 -0.032 0.03 -10000 0 -0.098 87 87
MAGED1 0.032 0.003 -10000 0 -10000 0 0
PTPN11 0.032 0.003 -10000 0 -10000 0 0
RICS 0 0 -10000 0 -10000 0 0
NT-4/5 (dimer) 0 0 -10000 0 -10000 0 0
SHC/GRB2/SOS1 0.035 0.024 -10000 0 -0.04 40 40
GRB2 0.032 0.006 -10000 0 -10000 0 0
NGF (dimer)/TRKA/MATK 0.042 0.011 -10000 0 -0.04 1 1
TRKA/NEDD4-2 0.046 0.011 -10000 0 -0.05 1 1
ELMO1 0.015 0.016 -10000 0 -10000 0 0
RhoG/GTP/ELMO1/DOCK1 0.017 0.021 -10000 0 -10000 0 0
NGF 0 0 -10000 0 -10000 0 0
HRAS 0.031 0.007 -10000 0 -10000 0 0
DOCK1 0.023 0.015 -10000 0 -10000 0 0
GAB2 0.032 0.006 -10000 0 -10000 0 0
RIT2 0.017 0.017 -10000 0 -0.063 2 2
RIT1 0.003 0.043 -10000 0 -0.063 152 152
FRS2 0.031 0.007 -10000 0 -10000 0 0
DNM1 0.006 0.012 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
CRK 0.032 0.005 -10000 0 -10000 0 0
SH2B1 (homopentamer) 0 0 -10000 0 -10000 0 0
RhoG/GTP 0.012 0.023 -10000 0 -10000 0 0
mol:GDP -0.002 0.074 0.2 19 -0.22 17 36
NGF (dimer) 0 0 -10000 0 -10000 0 0
RhoG/GDP 0.011 0.012 -10000 0 -10000 0 0
RIT1/GDP -0.002 0.053 0.14 12 -0.16 19 31
TIAM1 0.031 0.008 -10000 0 -10000 0 0
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
BDNF (dimer)/TRKB 0.012 0.028 -10000 0 -0.048 11 11
KIDINS220/CRKL/C3G 0.044 0.014 -10000 0 -10000 0 0
SHC/RasGAP 0.038 0.028 -10000 0 -0.05 40 40
FRS2 family/SHP2 0.062 0.017 -10000 0 -0.044 1 1
SHC/GRB2/SOS1/GAB1 0.05 0.033 -10000 0 -0.043 43 43
RIT1/GTP 0.005 0.029 -10000 0 -0.036 162 162
NT3 (dimer) 0.031 0.007 -10000 0 -10000 0 0
RAP1/GDP -0.002 0.04 -10000 0 -0.14 17 17
KIDINS220/CRKL 0.031 0.007 -10000 0 -10000 0 0
BDNF (dimer) 0.009 0.015 -10000 0 -10000 0 0
ubiquitin-dependent protein catabolic process 0.041 0.01 -10000 0 -0.039 1 1
Schwann cell development -0.002 0.006 -10000 0 -0.033 1 1
EHD4 0.026 0.023 -10000 0 -0.063 31 31
FRS2 family/GRB2/SOS1 0.058 0.018 -10000 0 -0.039 1 1
FRS2 family/SHP2/CRK family/C3G/GAB2 0.02 0.038 0.091 25 -0.13 22 47
RAP1B 0 0 -10000 0 -10000 0 0
RAP1A 0.032 0.004 -10000 0 0 9 9
CDC42/GTP 0.009 0.027 0.15 4 -10000 0 4
ABL1 0.031 0.008 -10000 0 -0.063 1 1
SH2B family/GRB2/SOS1 0.023 0.004 -10000 0 -10000 0 0
Rap1/GTP 0.001 0.034 -10000 0 -0.19 13 13
STAT3 0.017 0.042 -10000 0 -0.068 98 98
axon guidance -0.008 0.018 0.04 2 -10000 0 2
MAPK3 -0.013 0.044 0.18 25 -10000 0 25
MAPK1 -0.014 0.04 0.18 20 -10000 0 20
CDC42/GDP 0.006 0.053 0.14 17 -0.16 16 33
NTF3 0.031 0.007 -10000 0 -10000 0 0
NTF4 0 0 -10000 0 -10000 0 0
NGF (dimer)/TRKA/FAIM 0.039 0.018 -10000 0 -0.04 19 19
PI3K 0.039 0.023 -10000 0 -0.05 16 16
FRS3 0.032 0.002 -10000 0 -10000 0 0
FAIM 0.028 0.018 -10000 0 -0.063 18 18
GAB1 0.032 0.008 -10000 0 -0.063 3 3
RASGRF1 -0.009 0.018 0.074 13 -0.15 1 14
SOS1 0 0 -10000 0 -10000 0 0
MCF2L -0.02 0.011 -10000 0 -10000 0 0
RGS19 0.03 0.009 -10000 0 -10000 0 0
CDC42 0.031 0.006 -10000 0 -10000 0 0
RAS family/GTP 0.011 0.055 0.21 2 -0.26 11 13
Rac1/GDP 0.005 0.044 0.16 9 -0.16 9 18
NGF (dimer)/TRKA/GRIT 0.021 0.004 -10000 0 -0.031 1 1
neuron projection morphogenesis 0.014 0.072 -10000 0 -0.72 4 4
NGF (dimer)/TRKA/NEDD4-2 0.042 0.01 -10000 0 -0.04 1 1
MAP2K1 -0.02 0.043 0.17 23 -10000 0 23
NGFR 0.028 0.019 -10000 0 -0.063 21 21
NGF (dimer)/TRKA/GIPC/GAIP 0.002 0.014 -10000 0 -0.14 3 3
RAS family/GTP/PI3K 0.003 0.035 -10000 0 -0.12 27 27
FRS2 family/SHP2/GRB2/SOS1 0.071 0.023 -10000 0 -10000 0 0
NRAS 0.009 0.041 -10000 0 -0.063 125 125
GRB2/SOS1 0.023 0.004 -10000 0 -10000 0 0
PRKCI 0.032 0.006 -10000 0 -0.063 1 1
ChemicalAbstracts:146-91-8 0 0 -10000 0 -10000 0 0
RAC1 0.023 0.015 -10000 0 -10000 0 0
PRKCZ 0 0 -10000 0 -10000 0 0
MAPKKK cascade 0.023 0.048 -10000 0 -0.39 5 5
RASA1 0.032 0.006 -10000 0 -10000 0 0
TRKA/c-Abl 0.045 0.013 -10000 0 -0.05 2 2
SQSTM1 0.032 0.006 -10000 0 -0.063 1 1
BDNF (dimer)/TRKB/GIPC 0.013 0.035 -10000 0 -0.058 1 1
NGF (dimer)/TRKA/p62/Atypical PKCs 0.054 0.018 -10000 0 -0.031 12 12
MATK 0.032 0.006 -10000 0 -10000 0 0
NEDD4L 0.032 0.006 -10000 0 -10000 0 0
RAS family/GDP -0.013 0.034 -10000 0 -0.11 31 31
NGF (dimer)/TRKA 0.01 0.016 -10000 0 -0.16 1 1
Rac1/GTP -0.003 0.028 -10000 0 -0.13 8 8
FRS2 family/SHP2/CRK family 0.084 0.039 -10000 0 -10000 0 0
S1P4 pathway

Figure S95.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S95.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:S1P 0 0 -10000 0 -10000 0 0
GNAO1 0.003 0.009 -10000 0 -10000 0 0
CDC42/GTP -0.033 0.041 -10000 0 -0.13 32 32
PLCG1 0 0.013 0.073 5 -0.13 3 8
mol:GTP 0 0 -10000 0 -10000 0 0
GNAI2 0.032 0.006 -10000 0 -10000 0 0
GNAI3 0.021 0.03 -10000 0 -0.063 58 58
G12/G13 0.034 0.022 -10000 0 -10000 0 0
cell migration -0.032 0.04 -10000 0 -0.13 32 32
S1PR5 0 0 -10000 0 -10000 0 0
S1PR4 0 0 -10000 0 -10000 0 0
MAPK3 0 0.013 0.073 6 -0.13 3 9
MAPK1 0.001 0.01 0.073 6 -0.096 1 7
S1P/S1P5/Gi 0.002 0.012 0.083 6 -0.11 2 8
GNAI1 0.019 0.016 -10000 0 -0.063 1 1
CDC42/GDP 0.023 0.004 -10000 0 -10000 0 0
S1P/S1P5/G12 0.015 0.01 -10000 0 -10000 0 0
RHOA 0.039 0.095 0.18 148 -10000 0 148
S1P/S1P4/Gi 0.002 0.012 0.083 6 -0.11 2 8
mol:GDP 0 0 -10000 0 -10000 0 0
GNAZ 0.027 0.013 -10000 0 -10000 0 0
S1P/S1P4/G12/G13 0.029 0.019 -10000 0 -0.023 2 2
GNA12 0.023 0.015 -10000 0 -10000 0 0
GNA13 0.032 0.007 -10000 0 -0.063 2 2
CDC42 0.031 0.006 -10000 0 -10000 0 0
Arf1 pathway

Figure S96.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S96.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
coatomer protein complex 0.006 0.034 0.13 31 -0.14 3 34
EntrezGene:79658 0 0 -10000 0 -10000 0 0
ARF1/GDP/Membrin/GBF1/p115/Brefeldin A -0.006 0.041 0.12 4 -0.13 11 15
AP2 0.023 0.005 -10000 0 -10000 0 0
mol:DAG 0 0 -10000 0 -10000 0 0
Arfaptin 2/Rac/GTP 0.03 0.022 -10000 0 -0.04 1 1
CLTB 0.032 0.005 -10000 0 -10000 0 0
coatomer protein complex/ARF1/GTP/ER cargo protein 0.008 0.031 -10000 0 -0.1 35 35
CD4 0.028 0.019 -10000 0 -0.063 18 18
CLTA 0.03 0.009 -10000 0 -10000 0 0
mol:GTP -0.003 0.001 -10000 0 -10000 0 0
ARFGAP1 -0.01 0.003 0 43 -10000 0 43
mol:PI-4-5-P2 0.004 0.007 0.074 4 -0.034 1 5
ARF1/GTP 0.018 0.009 -10000 0 -0.036 10 10
coatomer protein complex/ARF1/GTP/ARF-GAP1/ER cargo protein -0.001 0.02 -10000 0 -0.09 24 24
mol:Choline 0.004 0.007 0.075 4 -0.034 1 5
mol:GDP 0 0 -10000 0 -10000 0 0
ARF1 0.032 0.006 -10000 0 -10000 0 0
DDEF1 0.002 0.007 0.074 4 -0.034 1 5
ARF1/GDP 0.004 0.012 -10000 0 -0.082 7 7
AP2M1 0.031 0.007 -10000 0 -10000 0 0
EntrezGene:1313 0 0 -10000 0 -10000 0 0
actin filament polymerization -0.011 0.009 -10000 0 -10000 0 0
Rac/GTP 0.017 0.011 0.047 1 -10000 0 1
ARF1/GTP/GGA3/ARF-GAP1 0.038 0.015 -10000 0 -0.031 1 1
ARFIP2 0.029 0.014 -10000 0 -0.035 18 18
COPA 0.032 0.005 -10000 0 -10000 0 0
RAC1 0.023 0.015 -10000 0 -10000 0 0
ARF1/GTP/coatomer protein complex 0.004 0.039 0.1 1 -0.14 30 31
ARF1/GTP/ARHGAP10 0.02 0.004 -10000 0 -10000 0 0
GGA3 0.032 0.004 -10000 0 -10000 0 0
ARF1/GTP/Membrin 0.024 0.024 -10000 0 -0.26 3 3
AP2A1 0 0 -10000 0 -10000 0 0
coatomer protein complex/ARF1/GTP/ARF-GAP1 0.005 0.028 -10000 0 -0.1 27 27
ARF1/GDP/Membrin 0.027 0.027 -10000 0 -0.29 3 3
Arfaptin 2/Rac/GDP 0.03 0.021 -10000 0 -0.038 1 1
CYTH2 -0.003 0.001 -10000 0 -10000 0 0
ARF1/GTP/GGA3 0.041 0.01 -10000 0 -10000 0 0
mol:ATP 0 0 -10000 0 -10000 0 0
Rac/GDP 0.017 0.011 -10000 0 -10000 0 0
mol:Brefeldin A 0 0 -10000 0 -10000 0 0
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex/Coatomer protein complex/ARF1/GTP 0.008 0.028 -10000 0 -0.092 29 29
PLD2 0.004 0.007 0.075 4 -0.034 1 5
ARF-GAP1/v-SNARE -0.01 0.003 0 43 -10000 0 43
PIP5K1A 0.004 0.007 0.074 4 -0.034 1 5
ARF1/GTP/Membrin/GBF1/p115 0.003 0.033 -10000 0 -0.056 120 120
mol:Phosphatic acid 0 0 -10000 0 -10000 0 0
mol:Phosphatidic acid 0.004 0.007 0.075 4 -0.034 1 5
KDEL Receptor/Ligand/ARF-GAP1 -0.01 0.003 0 43 -10000 0 43
GOSR2 0.011 0.029 -10000 0 -0.36 3 3
USO1 0.012 0.02 -10000 0 -0.29 2 2
GBF1 -0.063 0.14 -10000 0 -0.32 115 115
ARF1/GTP/Arfaptin 2 0.042 0.011 -10000 0 -10000 0 0
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex 0.037 0.02 -10000 0 -0.04 18 18
ErbB2/ErbB3 signaling events

Figure S97.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S97.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
USP8 -0.017 0.008 0.016 12 -10000 0 12
RAS family/GTP 0.015 0.056 -10000 0 -0.12 6 6
NFATC4 -0.026 0.039 0.24 5 -10000 0 5
ERBB2IP 0.027 0.023 -10000 0 -0.049 39 39
HSP90 (dimer) 0.03 0.008 -10000 0 -10000 0 0
mammary gland morphogenesis -0.031 0.031 0.14 5 -10000 0 5
JUN 0.001 0.046 0.19 6 -10000 0 6
HRAS 0.031 0.007 -10000 0 -10000 0 0
DOCK7 -0.032 0.025 0.12 5 -10000 0 5
ErbB2/ErbB3/neuregulin 1 beta/SHC 0.039 0.045 0.17 3 -10000 0 3
AKT1 -0.01 0.007 0.016 16 -10000 0 16
BAD -0.017 0.006 0.015 3 -10000 0 3
MAPK10 0.003 0.049 0.19 13 -10000 0 13
mol:GTP 0 0 -10000 0 -0.004 1 1
ErbB2/ErbB3/neuregulin 1 beta -0.032 0.034 0.15 5 -10000 0 5
RAF1 -0.019 0.064 0.22 20 -10000 0 20
ErbB2/ErbB3/neuregulin 2 0.032 0.03 -10000 0 -0.058 27 27
STAT3 0.027 0.091 -10000 0 -0.96 4 4
cell migration -0.014 0.047 0.21 9 -0.13 2 11
mol:PI-3-4-5-P3 -0.001 0.001 0.004 9 -10000 0 9
cell proliferation -0.004 0.099 0.44 3 -0.45 9 12
FOS -0.007 0.076 0.32 5 -0.27 11 16
NRAS 0.009 0.041 -10000 0 -0.063 125 125
mol:Ca2+ -0.031 0.031 0.14 5 -10000 0 5
MAPK3 0.009 0.066 0.39 4 -10000 0 4
MAPK1 -0.016 0.12 0.45 3 -0.49 15 18
JAK2 -0.031 0.034 0.12 6 -10000 0 6
NF2 0.009 0.004 -10000 0 -10000 0 0
ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 0.006 0.021 0.1 11 -0.057 1 12
NRG1 0.032 0.004 -10000 0 -10000 0 0
GRB2/SOS1 0.023 0.004 -10000 0 -10000 0 0
MAPK8 -0.017 0.057 0.17 2 -0.18 32 34
MAPK9 0.006 0.066 0.18 27 -10000 0 27
ERBB2 -0.026 0.02 0.05 32 -10000 0 32
ERBB3 0.023 0.024 -10000 0 -0.064 28 28
SHC1 0.024 0.026 -10000 0 -0.063 40 40
RAC1 0.023 0.015 -10000 0 -10000 0 0
apoptosis 0.009 0.005 -10000 0 -10000 0 0
STAT3 (dimer) 0.028 0.088 -10000 0 -0.93 4 4
RNF41 -0.022 0.009 -10000 0 -10000 0 0
FRAP1 -0.009 0.004 0.007 15 -10000 0 15
RAC1-CDC42/GTP -0.027 0.022 -10000 0 -0.086 2 2
ErbB2/ErbB2/HSP90 (dimer) -0.024 0.026 0.051 46 -10000 0 46
CHRNA1 0.006 0.069 0.36 4 -0.25 7 11
myelination -0.028 0.057 0.3 11 -10000 0 11
PPP3CB -0.026 0.029 0.12 4 -10000 0 4
KRAS 0.031 0.008 -10000 0 -10000 0 0
RAC1-CDC42/GDP 0.021 0.04 -10000 0 -0.11 4 4
NRG2 0.032 0.004 -10000 0 -10000 0 0
mol:GDP 0.006 0.021 0.1 11 -0.057 1 12
SOS1 0 0 -10000 0 -10000 0 0
MAP2K2 -0.023 0.059 0.2 20 -10000 0 20
SRC 0.031 0.008 -10000 0 -10000 0 0
mol:cAMP -0.001 0.001 0.003 3 -10000 0 3
PTPN11 -0.034 0.036 0.13 7 -10000 0 7
MAP2K1 -0.01 0.12 0.43 3 -0.53 21 24
heart morphogenesis -0.031 0.031 0.14 5 -10000 0 5
RAS family/GDP 0.018 0.061 -10000 0 -0.12 7 7
GRB2 0.032 0.006 -10000 0 -10000 0 0
PRKACA 0.017 0.005 -10000 0 -10000 0 0
CHRNE 0.002 0.014 0.066 6 -10000 0 6
HSP90AA1 0.03 0.008 -10000 0 -10000 0 0
activation of caspase activity 0.01 0.007 -10000 0 -0.016 16 16
nervous system development -0.031 0.031 0.14 5 -10000 0 5
CDC42 0.031 0.006 -10000 0 -10000 0 0
Circadian rhythm pathway

Figure S98.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S98.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
chromatin modification 0.02 0.064 -9999 0 -0.26 1 1
CLOCK 0.021 0.023 -9999 0 -0.033 2 2
TIMELESS/CRY2 0.01 0.052 -9999 0 -0.26 1 1
DEC1/BMAL1 0.045 0.011 -9999 0 -10000 0 0
ATR 0.032 0.005 -9999 0 -10000 0 0
NR1D1 -0.002 0.029 -9999 0 -0.24 1 1
ARNTL 0.022 0.024 -9999 0 -0.028 90 90
TIMELESS -0.01 0.044 -9999 0 -0.27 1 1
NPAS2 0.022 0.024 -9999 0 -0.029 94 94
CRY2 0.032 0.006 -9999 0 -10000 0 0
mol:CO 0.001 0.011 -9999 0 -10000 0 0
CHEK1 0.021 0.03 -9999 0 -0.063 58 58
mol:HEME -0.001 0.011 -9999 0 -10000 0 0
PER1 0.031 0.009 -9999 0 -0.063 3 3
BMAL/CLOCK/NPAS2 0.046 0.046 -9999 0 -0.066 1 1
BMAL1/CLOCK 0.011 0.041 -9999 0 -0.25 4 4
S phase of mitotic cell cycle 0.02 0.064 -9999 0 -0.26 1 1
TIMELESS/CHEK1/ATR 0.021 0.065 -9999 0 -0.26 1 1
mol:NADPH -0.001 0.011 -9999 0 -10000 0 0
PER1/TIMELESS 0.008 0.054 -9999 0 -0.27 1 1
PER1-2 / CRY1-2 0 0 -9999 0 -10000 0 0
DEC1 0.032 0.006 -9999 0 -10000 0 0
Regulation of p38-alpha and p38-beta

Figure S99.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S99.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
RIP1/MEKK3 0.042 0.013 -10000 0 -0.04 9 9
response to insulin stimulus 0 0 -10000 0 -10000 0 0
RIPK1 0.03 0.013 -10000 0 -0.063 9 9
response to stress 0 0 -10000 0 -10000 0 0
MAP2K6 0.032 0.004 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
MAP2K4 0.031 0.007 -10000 0 -10000 0 0
RAC1-CDC42/GTP/PAK family 0 0.013 -10000 0 -0.11 5 5
response to UV 0 0 -10000 0 -10000 0 0
YES1 0.017 0.034 -10000 0 -0.063 75 75
interleukin-1 receptor activity 0 0 -10000 0 -10000 0 0
tumor necrosis factor receptor activity 0 0 -10000 0 -10000 0 0
MAP3K3 0.032 0.003 -10000 0 -10000 0 0
FYN 0.029 0.011 -10000 0 -0.063 1 1
MAP3K12 0.032 0.005 -10000 0 -10000 0 0
FGR 0.029 0.017 -10000 0 -0.063 15 15
p38 alpha/TAB1 -0.019 0.049 -10000 0 -0.23 16 16
PRKG1 0.024 0.014 -10000 0 -10000 0 0
DUSP8 0.024 0.015 -10000 0 -10000 0 0
PGK/cGMP/p38 alpha 0.001 0.065 0.15 2 -0.25 14 16
apoptosis -0.019 0.047 -10000 0 -0.22 16 16
RAL/GTP 0.029 0.023 -10000 0 -0.04 12 12
LYN 0.021 0.031 -10000 0 -0.063 60 60
DUSP1 0.029 0.017 -10000 0 -0.063 16 16
PAK1 0.032 0.004 -10000 0 -10000 0 0
SRC 0.031 0.008 -10000 0 -10000 0 0
RAC1/OSM/MEKK3/MKK3 0.043 0.03 -10000 0 -0.039 1 1
TRAF6 0.032 0.005 -10000 0 -10000 0 0
RAC1 0.023 0.015 -10000 0 -10000 0 0
epidermal growth factor receptor activity 0 0 -10000 0 -10000 0 0
mol:LPS 0 0 -10000 0 -10000 0 0
mol:cGMP 0 0 -10000 0 -10000 0 0
CCM2 0 0 -10000 0 -10000 0 0
RAC1-CDC42/GTP 0.03 0.02 -10000 0 -10000 0 0
MAPK11 0.004 0.08 0.18 24 -0.25 16 40
BLK 0.032 0.005 -10000 0 -10000 0 0
HCK 0.014 0.036 -10000 0 -0.063 85 85
MAP2K3 0.032 0.004 -10000 0 -10000 0 0
DUSP16 0 0 -10000 0 -10000 0 0
DUSP10 0.03 0.012 -10000 0 -0.063 6 6
TRAF6/MEKK3 0.04 0.01 -10000 0 -0.023 9 9
MAP3K7IP1 0 0 -10000 0 -10000 0 0
MAPK14 0.009 0.075 0.16 16 -0.27 14 30
positive regulation of innate immune response 0.004 0.091 0.18 26 -0.32 14 40
LCK 0.031 0.01 -10000 0 -0.063 4 4
p38alpha-beta/MKP7 0.001 0.087 0.17 27 -0.3 14 41
p38alpha-beta/MKP5 0.012 0.094 0.19 20 -0.31 12 32
PGK/cGMP 0.018 0.01 -10000 0 -10000 0 0
PAK2 0.028 0.02 -10000 0 -0.063 21 21
p38alpha-beta/MKP1 0.011 0.096 0.2 20 -0.31 14 34
CDC42 0.031 0.006 -10000 0 -10000 0 0
RALB 0.032 0.005 -10000 0 -0.063 1 1
RALA 0.021 0.019 -10000 0 -0.063 11 11
PAK3 0.005 0.012 -10000 0 -10000 0 0
Effects of Botulinum toxin

Figure S100.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S100.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
STX1A 0 0.002 -10000 0 -10000 0 0
UniProt:P19321 0 0 -10000 0 -10000 0 0
RIMS1/UNC13B 0.043 0.015 -10000 0 -10000 0 0
STXBP1 0.003 0.009 -10000 0 -10000 0 0
ACh/CHRNA1 0.034 0.027 0.081 30 -0.036 40 70
RAB3GAP2/RIMS1/UNC13B 0.053 0.032 -10000 0 -0.044 6 6
mol:Ca2+ 0 0 -10000 0 -10000 0 0
UniProt:P30996 0 0 -10000 0 -10000 0 0
UniProt:Q60393 0 0 -10000 0 -10000 0 0
CST086 0 0 -10000 0 -10000 0 0
RIMS1 0.031 0.006 -10000 0 -10000 0 0
mol:ACh 0.018 0.035 0.065 149 -0.059 7 156
RAB3GAP2 0.032 0.006 -10000 0 -10000 0 0
STX1A/SNAP25/VAMP2 0.001 0.01 0.14 1 -10000 0 1
UniProt:P10844 0 0 -10000 0 -10000 0 0
muscle contraction 0.034 0.027 0.081 30 -0.036 40 70
UNC13B 0.03 0.009 -10000 0 -10000 0 0
CHRNA1 0.032 0.008 -10000 0 -0.063 3 3
UniProt:P10845 0 0 -10000 0 -10000 0 0
ACh/Synaptotagmin 1 0.002 0.01 0.074 4 -10000 0 4
SNAP25 0 0.001 -10000 0 -10000 0 0
VAMP2 0.003 0.001 -10000 0 -10000 0 0
SYT1 0.002 0.007 -10000 0 -10000 0 0
UniProt:Q00496 0 0 -10000 0 -10000 0 0
STXIA/STXBP1 0.001 0.004 -10000 0 -10000 0 0
STX1A/SNAP25 fragment 1/VAMP2 0.001 0.01 0.14 1 -10000 0 1
Cellular roles of Anthrax toxin

Figure S101.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S101.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ANTXR1 0.032 0.008 -10000 0 -0.063 3 3
ANTXR2 0 0 -10000 0 -10000 0 0
negative regulation of myeloid dendritic cell antigen processing and presentation -0.002 0 -10000 0 -0.008 3 3
monocyte activation -0.017 0.045 -10000 0 -0.33 7 7
MAP2K2 0.017 0.027 -10000 0 -0.58 1 1
MAP2K1 -0.008 0.002 -10000 0 -10000 0 0
MAP2K7 -0.008 0.002 -10000 0 -0.017 1 1
MAP2K6 -0.009 0.001 -10000 0 -10000 0 0
CYAA -0.007 0.001 0 1 -0.025 3 4
MAP2K4 -0.008 0.002 -10000 0 -0.017 1 1
IL1B -0.013 0.019 0.16 4 -0.079 6 10
Channel 0.021 0.004 -10000 0 -0.024 4 4
NLRP1 -0.009 0.002 -10000 0 -0.017 1 1
CALM1 0.029 0.01 -10000 0 -10000 0 0
negative regulation of phagocytosis -0.028 0.12 -10000 0 -0.37 55 55
mol:Ca2+ 0 0 -10000 0 -10000 0 0
regulation of endothelial cell proliferation 0.002 0 0.008 3 -10000 0 3
MAPK3 -0.009 0.001 -10000 0 -10000 0 0
MAPK1 -0.008 0.003 -10000 0 -0.017 1 1
PGR -0.009 0.001 -10000 0 -10000 0 0
PA/Cellular Receptors 0.022 0.004 -10000 0 -0.031 3 3
apoptosis -0.002 0 -10000 0 -0.008 3 3
LOC728358 0 0 -10000 0 -10000 0 0
Lethal toxin (unfolded) 0.02 0.004 -10000 0 -0.026 4 4
macrophage activation -0.014 0.004 -10000 0 -10000 0 0
TNF 0.032 0.006 -10000 0 -0.063 2 2
VCAM1 -0.017 0.045 -10000 0 -0.33 7 7
platelet activation -0.028 0.12 -10000 0 -0.37 55 55
MAPKKK cascade 0.004 0.017 0.064 1 -0.068 23 24
IL18 -0.014 0.013 0.11 2 -0.079 2 4
negative regulation of macrophage activation -0.002 0 -10000 0 -0.008 3 3
LEF -0.002 0 -10000 0 -0.008 3 3
CASP1 -0.006 0.007 -10000 0 -0.016 164 164
mol:cAMP -0.028 0.12 -10000 0 -0.37 55 55
necrosis -0.002 0 -10000 0 -0.008 3 3
intracellular pH reduction 0 0 -10000 0 -10000 0 0
PAGA 0 0 -10000 0 -10000 0 0
Edema toxin (unfolded) 0.02 0.004 -10000 0 -0.022 4 4
mol:Epigallocatechin-3-gallate (EGCG) 0 0 -10000 0 -10000 0 0
Glucocorticoid receptor regulatory network

Figure S102.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S102.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PCK2 -0.007 0.03 -10000 0 -0.26 6 6
SMARCC2 0.031 0.006 -10000 0 -10000 0 0
SMARCC1 0.029 0.018 -10000 0 -0.063 17 17
TBX21 0.006 0.016 -10000 0 -10000 0 0
SUMO2 0.032 0.005 -10000 0 -0.027 1 1
STAT1 (dimer) 0.022 0.035 -10000 0 -0.063 74 74
FKBP4 0.031 0.006 -10000 0 -10000 0 0
FKBP5 0.027 0.021 -10000 0 -0.063 26 26
GR alpha/HSP90/FKBP51/HSP90 0.08 0.054 -10000 0 -0.077 3 3
PRL -0.041 0.059 -10000 0 -10000 0 0
cortisol/GR alpha (dimer)/TIF2 -0.014 0.039 -10000 0 -10000 0 0
RELA 0.015 0.039 -10000 0 -0.069 39 39
FGG 0.12 0.14 0.27 25 -10000 0 25
GR beta/TIF2 0.005 0.049 -10000 0 -10000 0 0
IFNG -0.06 0.092 -10000 0 -0.22 24 24
apoptosis 0.02 0.091 -10000 0 -0.35 9 9
CREB1 0.036 0.011 -10000 0 -0.067 6 6
histone acetylation 0.009 0.014 -10000 0 -10000 0 0
BGLAP 0.01 0.017 -10000 0 -10000 0 0
GR/PKAc 0.093 0.054 -10000 0 -10000 0 0
NF kappa B1 p50/RelA 0.027 0.06 -10000 0 -0.1 38 38
SMARCD1 0.032 0.005 -10000 0 -10000 0 0
MDM2 0.003 0.027 0.11 26 -10000 0 26
GATA3 0.028 0.017 -10000 0 -10000 0 0
AKT1 0.029 0.009 -10000 0 -10000 0 0
CSF2 -0.071 0.072 -10000 0 -0.24 2 2
GSK3B 0.032 0.006 -10000 0 -0.027 1 1
NR1I3 0.024 0.09 -10000 0 -0.32 8 8
CSN2 0.12 0.14 0.26 31 -10000 0 31
BRG1/BAF155/BAF170/BAF60A 0.07 0.036 -10000 0 -0.051 14 14
NFATC1 0.035 0.007 -10000 0 -10000 0 0
POU2F1 0.034 0.01 -10000 0 -0.054 3 3
CDKN1A -0.014 0.051 -10000 0 -0.36 1 1
response to stress 0 0 -10000 0 -10000 0 0
response to UV 0 0.001 -10000 0 -10000 0 0
SFN 0.026 0.023 -10000 0 -0.063 31 31
GR alpha/HSP90/FKBP51/HSP90/14-3-3 0.087 0.062 -10000 0 -0.084 5 5
prolactin receptor activity 0 0 -10000 0 -10000 0 0
EGR1 0.024 0.091 -10000 0 -0.36 7 7
JUN 0.001 0.022 0.28 2 -10000 0 2
IL4 0.011 0.018 -10000 0 -10000 0 0
CDK5R1 0.026 0.013 -10000 0 -10000 0 0
PRKACA 0.032 0.006 -10000 0 -10000 0 0
cortisol/GR alpha (monomer)/AP-1 -0.027 0.038 -10000 0 -0.12 5 5
GR alpha/HSP90/FKBP51/HSP90/PP5C 0.093 0.056 -10000 0 -0.076 3 3
cortisol/GR alpha (monomer) -0.02 0.039 -10000 0 -10000 0 0
NCOA2 0.032 0.004 -10000 0 -10000 0 0
response to hypoxia 0 0 -10000 0 -10000 0 0
FOS 0.011 0.043 -10000 0 -0.08 4 4
AP-1/NFAT1-c-4 -0.015 0.042 0.24 1 -0.2 1 2
AFP -0.053 0.059 0.26 2 -0.37 1 3
SUV420H1 0.032 0.005 -10000 0 -10000 0 0
IRF1 0.001 0.044 0.17 18 -0.15 3 21
TP53 0.016 0.044 -10000 0 -10000 0 0
PPP5C 0.031 0.007 -10000 0 -10000 0 0
KRT17 -0.062 0.093 0.17 1 -0.21 24 25
KRT14 -0.042 0.069 0.17 13 -0.13 27 40
TBP 0.035 0.009 -10000 0 -10000 0 0
CREBBP 0.03 0.006 -10000 0 -10000 0 0
HDAC1 0.018 0.031 -10000 0 -0.065 61 61
HDAC2 0.029 0.011 -10000 0 -0.063 4 4
AP-1 -0.015 0.042 0.24 1 -0.2 1 2
MAPK14 0.032 0.006 -10000 0 -0.044 2 2
MAPK10 0.018 0.016 -10000 0 -10000 0 0
MAPK11 0.03 0.01 -10000 0 -0.027 1 1
KRT5 -0.06 0.092 -10000 0 -0.22 16 16
interleukin-1 receptor activity -0.001 0 -10000 0 -10000 0 0
NCOA1 0.031 0.011 -10000 0 -0.032 8 8
STAT1 0.022 0.035 -10000 0 -0.063 74 74
CGA 0.01 0.019 -10000 0 -0.11 1 1
NF kappa B1 p50/RelA/Cbp/cortisol/GR alpha (monomer)/HDAC2 0.053 0.08 0.14 6 -0.22 7 13
MAPK3 0.032 0.005 -10000 0 -0.026 3 3
MAPK1 0.03 0.009 -10000 0 -0.026 1 1
ICAM1 -0.017 0.07 0.13 1 -0.17 75 76
NFKB1 0.014 0.039 -10000 0 -0.07 41 41
MAPK8 0.005 0.018 -10000 0 -10000 0 0
MAPK9 0.032 0.006 -10000 0 -0.026 1 1
cortisol/GR alpha (dimer) 0.016 0.09 0.24 1 -0.35 10 11
BAX -0.012 0.057 -10000 0 -0.37 3 3
POMC -0.073 0.08 0.26 2 -0.38 1 3
EP300 0.028 0.009 -10000 0 -10000 0 0
cortisol/GR alpha (dimer)/p53 -0.015 0.041 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.011 0.034 0.22 3 -10000 0 3
SGK1 0.018 0.05 0.19 1 -0.16 15 16
IL13 -0.044 0.068 -10000 0 -0.24 3 3
IL6 -0.017 0.067 0.13 1 -0.18 64 65
PRKACG 0.031 0.006 -10000 0 -10000 0 0
IL5 -0.051 0.07 -10000 0 -0.27 4 4
IL2 -0.06 0.092 0.17 1 -0.21 17 18
CDK5 0.021 0.016 -10000 0 -10000 0 0
PRKACB 0.029 0.01 -10000 0 -10000 0 0
HSP90AA1 0.03 0.008 -10000 0 -10000 0 0
IL8 -0.025 0.083 0.13 1 -0.2 82 83
CDK5R1/CDK5 0.025 0.024 -10000 0 -10000 0 0
NF kappa B1 p50/RelA/PKAc 0.068 0.062 -10000 0 -0.11 3 3
cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 -0.012 0.042 -10000 0 -10000 0 0
SMARCA4 0.031 0.007 -10000 0 -10000 0 0
chromatin remodeling 0.073 0.079 0.17 7 -0.19 3 10
NF kappa B1 p50/RelA/Cbp 0.04 0.075 -10000 0 -0.15 2 2
JUN (dimer) 0.001 0.022 0.28 2 -10000 0 2
YWHAH 0.015 0.016 -10000 0 -10000 0 0
VIPR1 0.008 0.034 0.34 4 -10000 0 4
NR3C1 -0.016 0.03 -10000 0 -10000 0 0
NR4A1 0.034 0.006 -10000 0 -10000 0 0
TIF2/SUV420H1 0.046 0.01 -10000 0 -10000 0 0
MAPKKK cascade 0.02 0.091 -10000 0 -0.35 9 9
cortisol/GR alpha (dimer)/Src-1 -0.013 0.038 -10000 0 -10000 0 0
PBX1 0.034 0.01 -10000 0 -0.054 5 5
POU1F1 0.033 0.011 -10000 0 -0.055 6 6
SELE -0.016 0.068 0.13 1 -0.17 77 78
cortisol/GR alpha/BRG1/BAF155/BAF170/BAF60A 0.073 0.08 0.17 10 -0.19 3 13
cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 -0.012 0.042 -10000 0 -10000 0 0
mol:cortisol -0.011 0.02 -10000 0 -10000 0 0
MMP1 0.002 0.046 -10000 0 -0.48 3 3
Nongenotropic Androgen signaling

Figure S103.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S103.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.011 0.002 -10000 0 -10000 0 0
GNB1/GNG2 0.037 0.017 -10000 0 -0.027 27 27
regulation of S phase of mitotic cell cycle 0.014 0.022 -10000 0 -0.1 12 12
GNAO1 0.003 0.009 -10000 0 -10000 0 0
HRAS 0.031 0.007 -10000 0 -10000 0 0
SHBG/T-DHT 0.021 0.004 -10000 0 0 17 17
PELP1 0.032 0.005 -10000 0 -10000 0 0
AKT1 -0.011 0.003 0 35 -10000 0 35
MAP2K1 -0.029 0.048 0.14 33 -0.14 2 35
T-DHT/AR 0.023 0.008 -10000 0 -0.039 8 8
G-protein coupled receptor activity 0 0 -10000 0 -10000 0 0
mol:GTP 0 0.001 -10000 0 -0.003 8 8
GNAI2 0.032 0.006 -10000 0 -10000 0 0
GNAI3 0.021 0.03 -10000 0 -0.063 58 58
GNAI1 0.019 0.016 -10000 0 -0.063 1 1
mol:GDP -0.012 0.008 -10000 0 -10000 0 0
cell proliferation -0.023 0.067 0.22 11 -0.28 3 14
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
FOS -0.023 0.066 0.2 5 -0.28 4 9
mol:Ca2+ 0 0.002 -10000 0 -0.033 2 2
MAPK3 -0.021 0.061 0.2 17 -0.24 2 19
MAPK1 -0.025 0.098 -10000 0 -0.36 35 35
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
mol:IP3 0 0.001 -10000 0 -0.003 3 3
cAMP biosynthetic process -0.001 0.003 -10000 0 -10000 0 0
GNG2 0 0 -10000 0 -10000 0 0
potassium channel inhibitor activity 0 0.001 -10000 0 -0.003 3 3
HRAS/GTP 0.049 0.03 -10000 0 -0.066 4 4
actin cytoskeleton reorganization 0.029 0.029 -10000 0 -0.044 11 11
SRC 0.03 0.008 -10000 0 -10000 0 0
voltage-gated calcium channel activity 0 0.001 -10000 0 -0.003 3 3
PI3K 0.036 0.02 -10000 0 -0.04 16 16
apoptosis 0.015 0.065 0.23 9 -0.21 4 13
T-DHT/AR/PELP1 0.041 0.013 -10000 0 -0.041 9 9
HRAS/GDP 0.016 0.033 0.1 8 -10000 0 8
CREB1 -0.016 0.066 0.22 4 -0.23 8 12
RAC1-CDC42/GTP 0.036 0.035 -10000 0 -0.051 1 1
AR 0.031 0.012 -10000 0 -0.063 8 8
GNB1 0.031 0.008 -10000 0 -10000 0 0
RAF1 -0.022 0.051 0.16 35 -10000 0 35
RAC1-CDC42/GDP 0.027 0.03 0.13 1 -10000 0 1
T-DHT/AR/PELP1/Src 0.055 0.022 -10000 0 -0.043 9 9
MAP2K2 -0.032 0.043 0.14 24 -0.14 2 26
T-DHT/AR/PELP1/Src/PI3K 0.014 0.022 -10000 0 -0.1 12 12
GNAZ 0.027 0.013 -10000 0 -10000 0 0
SHBG 0.032 0.006 -10000 0 -10000 0 0
Gi family/GNB1/GNG2/GDP -0.065 0.1 -10000 0 -0.35 38 38
mol:T-DHT 0 0 -10000 0 -0.002 5 5
RAC1 0.023 0.015 -10000 0 -10000 0 0
GNRH1 -0.011 0.002 0 11 -10000 0 11
Gi family/GTP 0 0.008 -10000 0 -0.11 2 2
CDC42 0.031 0.006 -10000 0 -10000 0 0
Angiopoietin receptor Tie2-mediated signaling

Figure S104.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S104.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
AKT1 -0.051 0.073 -10000 0 -10000 0 0
NCK1/PAK1/Dok-R -0.031 0.04 -10000 0 -0.24 1 1
NCK1/Dok-R -0.005 0.06 -10000 0 -10000 0 0
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
mol:beta2-estradiol 0.004 0.013 -10000 0 -10000 0 0
RELA 0.032 0.004 -10000 0 -10000 0 0
SHC1 0.024 0.026 -10000 0 -0.063 40 40
Rac/GDP 0.017 0.011 -10000 0 -10000 0 0
F2 0.037 0.019 -10000 0 -0.064 2 2
TNIP2 0.03 0.014 -10000 0 -0.063 11 11
NF kappa B/RelA 0.015 0.081 -10000 0 -10000 0 0
FN1 0.014 0.037 -10000 0 -0.063 96 96
PLD2 -0.013 0.04 -10000 0 -0.24 1 1
PTPN11 0.032 0.003 -10000 0 -10000 0 0
GRB14 0.029 0.018 -10000 0 -0.063 18 18
ELK1 -0.024 0.051 -10000 0 -10000 0 0
GRB7 0.032 0.005 -10000 0 -0.063 1 1
PAK1 0.032 0.004 -10000 0 -10000 0 0
Tie2/Ang1/alpha5/beta1 Integrin -0.011 0.079 -10000 0 -0.24 1 1
CDKN1A -0.057 0.078 -10000 0 -0.36 2 2
ITGA5 0.019 0.033 -10000 0 -0.063 68 68
mol:GTP 0 0 -10000 0 -10000 0 0
RasGAP/Dok-R -0.004 0.06 -10000 0 -10000 0 0
CRK 0.032 0.005 -10000 0 -10000 0 0
mol:NO -0.006 0.095 0.28 4 -10000 0 4
PLG -0.011 0.037 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
chemokinesis -0.012 0.082 -10000 0 -10000 0 0
GRB2 0.032 0.006 -10000 0 -10000 0 0
PIK3R1 0.029 0.009 -10000 0 -10000 0 0
ANGPT2 -0.049 0.069 -10000 0 -0.39 2 2
BMX -0.013 0.04 -10000 0 -0.24 1 1
ANGPT1 -0.007 0.037 -10000 0 -0.2 1 1
tube development -0.061 0.074 -10000 0 -0.32 1 1
ANGPT4 0.029 0.008 -10000 0 -10000 0 0
response to hypoxia -0.003 0.005 -10000 0 -10000 0 0
Tie2/Ang1/GRB14 -0.006 0.063 -10000 0 -10000 0 0
alpha5/beta1 Integrin 0.025 0.034 -10000 0 -0.05 61 61
FGF2 0.034 0.007 -10000 0 -0.061 2 2
STAT5A (dimer) -0.061 0.091 -10000 0 -10000 0 0
mol:L-citrulline -0.006 0.095 0.28 4 -10000 0 4
AGTR1 0.022 0.02 -10000 0 -0.028 67 67
MAPK14 -0.02 0.072 -10000 0 -0.56 3 3
Tie2/SHP2 -0.028 0.12 -10000 0 -0.27 99 99
TEK -0.037 0.12 -10000 0 -0.29 94 94
RPS6KB1 -0.046 0.072 -10000 0 -0.37 1 1
Angiotensin II/AT1 0 0.023 -10000 0 -0.022 239 239
Tie2/Ang1/GRB2 -0.004 0.063 -10000 0 -10000 0 0
MAPK3 -0.029 0.046 0.19 1 -0.24 1 2
MAPK1 -0.026 0.044 -10000 0 -0.24 1 1
Tie2/Ang1/GRB7 -0.004 0.064 -10000 0 -10000 0 0
NFKB1 0.031 0.009 -10000 0 -0.063 4 4
MAPK8 -0.008 0.03 -10000 0 -0.24 1 1
PI3K -0.041 0.073 -10000 0 -0.39 1 1
FES -0.022 0.072 -10000 0 -0.44 3 3
Crk/Dok-R -0.005 0.061 -10000 0 -10000 0 0
Tie2/Ang1/ABIN2 -0.005 0.063 -10000 0 -10000 0 0
blood circulation 0 0 -10000 0 -10000 0 0
negative regulation of caspase activity -0.05 0.071 -10000 0 -0.33 1 1
STAT5A 0.032 0.005 -10000 0 -0.063 1 1
mol:ROS 0 0 -10000 0 -10000 0 0
PTK2 -0.044 0.076 0.29 3 -10000 0 3
Tie2/Ang2 -0.059 0.083 -10000 0 -0.36 1 1
Tie2/Ang1 -0.004 0.043 -10000 0 -0.25 1 1
FOXO1 -0.058 0.074 -10000 0 -10000 0 0
ELF1 0.035 0.018 -10000 0 -0.063 6 6
ELF2 -0.007 0.037 -10000 0 -0.21 1 1
mol:Choline -0.013 0.041 -10000 0 -0.24 1 1
cell migration -0.022 0.03 -10000 0 -10000 0 0
FYN -0.063 0.077 -10000 0 -0.34 1 1
DOK2 0 0 -10000 0 -10000 0 0
negative regulation of cell cycle -0.053 0.074 -10000 0 -0.37 1 1
ETS1 0.023 0.031 -10000 0 -10000 0 0
PXN -0.044 0.076 0.27 3 -10000 0 3
ITGB1 0.025 0.014 -10000 0 -10000 0 0
NOS3 -0.012 0.095 0.31 3 -0.32 1 4
RAC1 0.023 0.015 -10000 0 -10000 0 0
TNF 0.021 0.031 -10000 0 -0.055 44 44
MAPKKK cascade -0.013 0.041 -10000 0 -0.24 1 1
RASA1 0.032 0.006 -10000 0 -10000 0 0
Tie2/Ang1/Shc -0.011 0.062 -10000 0 -10000 0 0
NCK1 0.03 0.015 -10000 0 -0.063 11 11
vasculogenesis -0.002 0.092 0.26 5 -10000 0 5
mol:Phosphatidic acid -0.013 0.041 -10000 0 -0.24 1 1
mol:Angiotensin II -0.003 0.004 -10000 0 -10000 0 0
mol:NADP -0.006 0.095 0.28 4 -10000 0 4
Rac1/GTP -0.026 0.064 -10000 0 -0.36 1 1
MMP2 -0.019 0.04 -10000 0 -0.26 1 1
Nephrin/Neph1 signaling in the kidney podocyte

Figure S105.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S105.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
positive regulation of NF-kappaB transcription factor activity -0.049 0.018 0.054 1 -0.12 4 5
KIRREL 0.035 0.011 0.084 1 -0.038 5 6
Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.049 0.019 0.12 4 -0.054 1 5
PLCG1 0.03 0.009 -10000 0 -10000 0 0
ARRB2 0.032 0.005 -10000 0 -10000 0 0
WASL 0.023 0.015 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/CD2AP 0.069 0.046 0.18 7 -10000 0 7
ChemicalAbstracts:57-88-5 0 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.016 0.019 -10000 0 -0.11 5 5
FYN -0.009 0.045 0.17 28 -10000 0 28
mol:Ca2+ 0.074 0.036 0.17 19 -10000 0 19
mol:DAG 0.076 0.037 0.18 19 -10000 0 19
NPHS2 0.035 0.01 0.084 1 -0.03 4 5
mol:IP3 0.076 0.037 0.18 19 -10000 0 19
regulation of endocytosis 0.055 0.03 0.14 1 -0.059 4 5
Nephrin/NEPH1/podocin/Cholesterol 0.062 0.029 0.16 19 -0.04 3 22
establishment of cell polarity 0.049 0.018 0.12 4 -0.054 1 5
Nephrin/NEPH1/podocin/NCK1-2 0.091 0.039 0.2 2 -10000 0 2
Nephrin/NEPH1/beta Arrestin2 0.058 0.03 0.14 1 -0.06 4 5
NPHS1 0.035 0.011 0.093 1 -10000 0 1
Nephrin/NEPH1/podocin 0.059 0.024 0.17 4 -0.056 4 8
TJP1 0.032 0.005 -10000 0 -10000 0 0
NCK1 0.03 0.015 -10000 0 -0.063 11 11
NCK2 0.032 0.004 -10000 0 -10000 0 0
heterophilic cell adhesion 0 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/PLCgamma1 0.077 0.038 0.18 19 -10000 0 19
CD2AP 0.023 0.028 -10000 0 -0.063 48 48
Nephrin/NEPH1/podocin/GRB2 0.079 0.035 0.18 16 -10000 0 16
GRB2 0.032 0.006 -10000 0 -10000 0 0
homophilic cell adhesion 0 0 -10000 0 -10000 0 0
TRPC6 -0.012 0.052 0.18 30 -10000 0 30
cytoskeleton organization -0.008 0.032 0.17 11 -0.15 3 14
Nephrin/NEPH1 0.041 0.016 0.097 4 -0.029 5 9
Nephrin/NEPH1/ZO-1 0.063 0.024 -10000 0 -0.044 5 5
IL12-mediated signaling events

Figure S106.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S106.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IL12/IL12R/TYK2/JAK2/SOCS1 0.002 0.056 -10000 0 -0.17 22 22
TBX21 -0.019 0.12 -10000 0 -0.41 1 1
B2M 0.032 0.006 -10000 0 -10000 0 0
TYK2 0.021 0.029 -10000 0 -10000 0 0
IL12RB1 0.021 0.029 -10000 0 -10000 0 0
GADD45B 0.003 0.095 -10000 0 -0.44 1 1
IL12RB2 0.02 0.03 -10000 0 -10000 0 0
GADD45G 0.002 0.1 0.37 1 -0.46 4 5
natural killer cell activation -0.002 0.01 -10000 0 -10000 0 0
RELB 0.031 0.008 -10000 0 -0.063 1 1
RELA 0.032 0.004 -10000 0 -10000 0 0
IL18 0.025 0.027 -10000 0 -0.063 43 43
IL2RA 0.023 0.017 -10000 0 -0.063 6 6
IFNG 0.03 0.008 -10000 0 -10000 0 0
STAT3 (dimer) -0.005 0.11 0.27 2 -0.4 4 6
HLA-DRB5 -0.001 0.002 -10000 0 -10000 0 0
FASLG -0.017 0.12 0.33 2 -0.41 1 3
NF kappa B2 p52/RelB -0.008 0.13 -10000 0 -0.37 6 6
CD4 0.027 0.019 -10000 0 -0.063 19 19
SOCS1 0.032 0.004 -10000 0 -10000 0 0
EntrezGene:6955 -0.001 0.002 -10000 0 -10000 0 0
CD3D 0.027 0.019 -10000 0 -0.063 21 21
CD3E 0.031 0.007 -10000 0 -0.048 2 2
CD3G 0.031 0.007 -10000 0 -0.051 2 2
IL12Rbeta2/JAK2 0.031 0.04 -10000 0 -10000 0 0
CCL3 -0.018 0.12 -10000 0 -0.36 5 5
CCL4 -0.067 0.23 -10000 0 -0.61 72 72
HLA-A 0.032 0.005 -10000 0 -0.063 1 1
IL18/IL18R 0.058 0.042 -10000 0 -10000 0 0
NOS2 -0.013 0.1 -10000 0 -0.39 3 3
IL12/IL12R/TYK2/JAK2/SPHK2 0.002 0.058 -10000 0 -0.18 24 24
IL1R1 -0.02 0.12 0.39 1 -0.4 2 3
IL4 0.034 0.014 -10000 0 -0.028 8 8
JAK2 0.019 0.029 -10000 0 -10000 0 0
EntrezGene:6957 -0.001 0.002 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8 0.008 0.035 -10000 0 -0.12 24 24
RAB7A 0.013 0.098 0.34 3 -10000 0 3
lysosomal transport 0.013 0.096 0.34 3 -10000 0 3
FOS -0.058 0.17 -10000 0 -0.58 41 41
STAT4 (dimer) -0.015 0.12 0.38 2 -0.48 3 5
STAT5A (dimer) 0 0.13 -10000 0 -0.37 4 4
GZMA -0.024 0.12 -10000 0 -0.41 1 1
GZMB -0.025 0.12 -10000 0 -0.41 1 1
HLX 0.031 0.009 -10000 0 -0.063 3 3
LCK -0.025 0.12 0.26 4 -0.36 15 19
TCR/CD3/MHC II/CD4 -0.009 0.031 -10000 0 -0.1 6 6
IL2/IL2R 0.049 0.056 -10000 0 -0.067 6 6
MAPK14 0.014 0.1 0.36 1 -0.47 2 3
CCR5 -0.002 0.11 -10000 0 -0.53 4 4
IL1B 0.018 0.033 -10000 0 -0.065 13 13
STAT6 0.003 0.066 -10000 0 -0.38 8 8
STAT4 0.019 0.016 -10000 0 -10000 0 0
STAT3 0.03 0.014 -10000 0 -0.063 10 10
STAT1 0.029 0.018 -10000 0 -0.063 18 18
NFKB1 0.031 0.009 -10000 0 -0.063 4 4
NFKB2 0.024 0.014 -10000 0 -10000 0 0
IL12B 0.021 0.03 -10000 0 -10000 0 0
CD8A 0 0 -10000 0 -10000 0 0
CD8B 0.032 0.006 -10000 0 -0.063 2 2
T-helper 1 cell differentiation 0 0 -10000 0 -10000 0 0
natural killer cell mediated cytotoxicity -0.003 0.056 0.17 22 -10000 0 22
IL2RB 0.03 0.011 -10000 0 -0.063 4 4
proteasomal ubiquitin-dependent protein catabolic process -0.013 0.11 0.38 2 -0.45 3 5
IL2RG 0.031 0.013 -10000 0 -0.063 9 9
IL12 0.032 0.042 -10000 0 -10000 0 0
STAT5A 0.032 0.005 -10000 0 -0.063 1 1
CD247 0.031 0.008 -10000 0 -0.054 3 3
IL2 0.032 0.004 -10000 0 -10000 0 0
SPHK2 0.031 0.008 -10000 0 -10000 0 0
FRAP1 0 0 -10000 0 -10000 0 0
IL12A 0.02 0.03 -10000 0 -10000 0 0
IL12/IL12R/TYK2/JAK2 -0.018 0.12 -10000 0 -0.37 17 17
MAP2K3 0.009 0.1 0.35 1 -0.53 2 3
RIPK2 0.032 0.006 -10000 0 -0.063 1 1
MAP2K6 0.01 0.1 0.35 1 -0.47 1 2
regulation of dendritic cell antigen processing and presentation 0 0 -10000 0 -10000 0 0
HLA-DRA -0.021 0.047 -10000 0 -0.064 280 280
IL18RAP 0.033 0.006 -10000 0 -0.028 1 1
IL12Rbeta1/TYK2 0.032 0.039 -10000 0 -10000 0 0
EOMES 0.004 0.019 0.073 4 -0.079 4 8
STAT1 (dimer) -0.002 0.11 -10000 0 -0.41 2 2
T cell proliferation -0.018 0.095 0.38 1 -0.39 4 5
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
IL18R1 0.033 0.006 -10000 0 -10000 0 0
CD8-positive alpha-beta T cell lineage commitment 0 0 -10000 0 -10000 0 0
NF kappa B1 p50/RelA 0.014 0.12 -10000 0 -0.41 3 3
ATF2 0.007 0.1 0.53 1 -0.45 2 3
Sphingosine 1-phosphate (S1P) pathway

Figure S107.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S107.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPHK2 0.031 0.008 -10000 0 -10000 0 0
SPHK1 0.029 0.018 -10000 0 -0.063 19 19
GNAI2 0.032 0.006 -10000 0 -10000 0 0
mol:S1P 0.009 0.01 -10000 0 -0.031 23 23
GNAO1 0.003 0.009 -10000 0 -10000 0 0
mol:Sphinganine-1-P -0.022 0.008 0 34 -0.05 19 53
growth factor activity 0 0 -10000 0 -10000 0 0
S1P/S1P2/G12/G13 0.028 0.035 -10000 0 -0.11 14 14
GNAI3 0.021 0.03 -10000 0 -0.063 58 58
G12/G13 0.034 0.022 -10000 0 -10000 0 0
S1PR3 0 0 -10000 0 -10000 0 0
S1PR2 0 0 -10000 0 -10000 0 0
EDG1 0 0 -10000 0 -10000 0 0
S1P1/S1P 0.002 0.024 -10000 0 -0.11 21 21
S1PR5 0 0 -10000 0 -10000 0 0
S1PR4 0 0 -10000 0 -10000 0 0
GNAI1 0.019 0.016 -10000 0 -0.063 1 1
S1P/S1P5/G12 0.016 0.027 -10000 0 -0.11 14 14
S1P/S1P3/Gq 0.02 0.045 0.15 9 -0.28 8 17
S1P/S1P4/Gi -0.005 0.041 -10000 0 -0.21 17 17
GNAQ 0.031 0.006 -10000 0 -10000 0 0
GNAZ 0.027 0.013 -10000 0 -10000 0 0
GNA14 0.031 0.009 -10000 0 -0.063 2 2
GNA15 0.03 0.013 -10000 0 -0.016 27 27
GNA12 0.023 0.015 -10000 0 -10000 0 0
GNA13 0.032 0.007 -10000 0 -0.063 2 2
GNA11 0.031 0.006 -10000 0 -10000 0 0
ABCC1 0.031 0.012 -10000 0 -0.063 8 8
S1P5 pathway

Figure S108.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S108.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:S1P 0 0 -10000 0 -10000 0 0
telencephalon oligodendrocyte cell migration 0.033 0.04 0.12 33 -10000 0 33
GNAI2 0.032 0.006 -10000 0 -10000 0 0
S1P/S1P5/G12 0.015 0.01 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
GNAO1 0.003 0.009 -10000 0 -10000 0 0
RhoA/GTP -0.033 0.041 -10000 0 -0.13 33 33
negative regulation of cAMP metabolic process 0.002 0.012 0.082 6 -0.11 2 8
GNAZ 0.027 0.013 -10000 0 -10000 0 0
GNAI3 0.021 0.03 -10000 0 -0.063 58 58
GNA12 0.023 0.015 -10000 0 -10000 0 0
S1PR5 0 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
S1P/S1P5/Gi 0.002 0.012 0.083 6 -0.11 2 8
RhoA/GDP 0.023 0.004 -10000 0 0 15 15
RHOA 0.032 0.006 -10000 0 -10000 0 0
GNAI1 0.019 0.016 -10000 0 -0.063 1 1
Aurora C signaling

Figure S109.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S109.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
INCENP 0.032 0.004 -9999 0 -10000 0 0
Aurora C/Aurora B/INCENP 0.05 0.033 -9999 0 -0.043 32 32
metaphase 0 0 -9999 0 -10000 0 0
mitosis 0 0 -9999 0 -10000 0 0
H3F3B 0.009 0.016 -9999 0 -0.33 1 1
AURKB 0.027 0.021 -9999 0 -0.063 26 26
AURKC 0.03 0.01 -9999 0 -0.063 2 2
Atypical NF-kappaB pathway

Figure S110.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S110.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL3/RelA 0.045 0.012 -10000 0 -10000 0 0
FBXW11 0.032 0.005 -10000 0 -10000 0 0
NF kappa B1 p50/c-Rel 0.028 0.011 -10000 0 -0.04 11 11
NF kappa B1 p50/RelA/I kappa B alpha 0.022 0.051 0.17 3 -0.21 7 10
NFKBIA 0.003 0.033 0.11 23 -0.097 29 52
MAPK14 0.032 0.005 -10000 0 -0.063 1 1
NF kappa B1 p105/p50 0.028 0.011 -10000 0 -0.039 10 10
ARRB2 0.013 0.003 -10000 0 -0.036 1 1
REL 0.032 0.002 -10000 0 -10000 0 0
response to oxidative stress 0 0 -10000 0 -10000 0 0
BCL3/NF kappa B1 p50 0.027 0.012 -10000 0 -0.041 9 9
response to UV 0 0 -10000 0 -10000 0 0
NF kappa B1 p105/RelA 0.028 0.011 -10000 0 -0.04 11 11
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
NF kappa B1 p50 dimer -0.022 0.018 0.26 2 -10000 0 2
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
NFKB1 -0.022 0.004 0 12 -0.05 4 16
RELA 0.032 0.004 -10000 0 -10000 0 0
positive regulation of anti-apoptosis 0.01 0.028 0.11 2 -0.14 6 8
NF kappa B1 p50/RelA/I kappa B alpha/beta Arrestin2 0.023 0.053 0.17 3 -0.2 10 13
SRC 0.031 0.008 -10000 0 -10000 0 0
PI3K 0.039 0.023 -10000 0 -0.05 16 16
NF kappa B1 p50/RelA 0.011 0.026 0.11 2 -0.14 6 8
IKBKB 0.032 0.003 -10000 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.032 0.005 -10000 0 -10000 0 0
SYK 0.025 0.024 -10000 0 -0.063 34 34
I kappa B alpha/PIK3R1 0.02 0.047 0.18 3 -0.2 7 10
cell death 0.022 0.051 0.16 3 -0.19 10 13
NF kappa B1 p105/c-Rel 0.028 0.011 -10000 0 -0.04 11 11
LCK 0.031 0.01 -10000 0 -0.063 4 4
BCL3 0.031 0.007 -10000 0 -10000 0 0
Insulin Pathway

Figure S111.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S111.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CBL/APS/CAP 0.033 0.041 -10000 0 -0.055 3 3
TC10/GTP 0.026 0.041 -10000 0 -10000 0 0
Insulin Receptor/Insulin/IRS1/Shp2 0.078 0.033 -10000 0 -10000 0 0
HRAS 0.031 0.007 -10000 0 -10000 0 0
APS homodimer 0 0 -10000 0 -10000 0 0
GRB14 0.029 0.018 -10000 0 -0.063 18 18
FOXO3 -0.021 0.14 -10000 0 -0.57 29 29
AKT1 -0.022 0.062 0.29 5 -10000 0 5
INSR 0.034 0.01 0.07 20 -10000 0 20
Insulin Receptor/Insulin 0.058 0.032 0.22 4 -10000 0 4
mol:GTP 0 0 -10000 0 -10000 0 0
GRB10 0.021 0.018 -10000 0 -0.063 6 6
SORBS1 0.024 0.014 -10000 0 -10000 0 0
CRK 0.032 0.005 -10000 0 -10000 0 0
PTPN1 -0.019 0.022 0.14 7 -10000 0 7
CAV1 -0.025 0.029 0.18 4 -10000 0 4
CBL/APS/CAP/Crk-II/C3G 0.045 0.051 -10000 0 -10000 0 0
Insulin Receptor/Insulin/IRS1/NCK2 0.078 0.033 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 0.053 0.038 -10000 0 -10000 0 0
Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B 0.028 0.037 0.18 16 -0.19 3 19
RPS6KB1 -0.027 0.057 0.27 5 -10000 0 5
PARD6A 0.032 0.004 -10000 0 -10000 0 0
CBL 0.032 0.004 -10000 0 -10000 0 0
tumor necrosis factor-mediated signaling pathway 0 0 -10000 0 -10000 0 0
DOK1 0.02 0.014 -10000 0 -10000 0 0
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
Insulin Receptor/Insuli/IRS1/GRB2/Shc -0.033 0.058 0.15 23 -10000 0 23
HRAS/GTP -0.032 0.018 0.029 21 -10000 0 21
Insulin Receptor 0.034 0.01 0.07 20 -10000 0 20
Insulin Receptor/Insuli/IRS1/GRB2/SHC 0.075 0.054 -10000 0 -0.072 1 1
PRKCI 0.035 0.035 -10000 0 -0.32 4 4
Insulin Receptor/Insulin/GRB14/PDK1 0.03 0.033 -10000 0 -10000 0 0
SHC1 0.024 0.026 -10000 0 -0.063 40 40
negative regulation of MAPKKK cascade 0.033 0.044 -10000 0 -10000 0 0
PI3K 0.065 0.044 -10000 0 -10000 0 0
NCK2 0.032 0.004 -10000 0 -10000 0 0
RHOQ 0.032 0.002 -10000 0 -10000 0 0
mol:H2O2 -0.003 0.003 -10000 0 -10000 0 0
HRAS/GDP 0.023 0.005 -10000 0 -10000 0 0
AKT2 -0.026 0.059 0.29 5 -10000 0 5
PRKCZ 0.017 0.017 -10000 0 -0.29 1 1
SH2B2 0 0 -10000 0 -10000 0 0
SHC/SHIP -0.019 0.037 0.16 16 -10000 0 16
F2RL2 0.032 0.004 -10000 0 -10000 0 0
TRIP10 0.031 0.012 -10000 0 -0.063 6 6
Insulin Receptor/Insulin/Shc 0.05 0.037 -10000 0 -0.043 40 40
TC10/GTP/CIP4/Exocyst 0.042 0.012 -10000 0 -0.04 6 6
Insulin Receptor/Insulin/SHC/GRB2/Sos1 0.06 0.044 -10000 0 -10000 0 0
RAPGEF1 0.031 0.006 -10000 0 -10000 0 0
RASA1 0.032 0.006 -10000 0 -10000 0 0
NCK1 0.03 0.015 -10000 0 -0.063 11 11
CBL/APS/CAP/Crk-II 0.037 0.042 -10000 0 -0.032 135 135
TC10/GDP 0.024 0.002 -10000 0 -10000 0 0
Insulin Receptor/Insulin/SHC/GRB10 0.044 0.051 -10000 0 -0.071 1 1
INPP5D -0.019 0.013 0.032 26 -10000 0 26
SOS1 0 0 -10000 0 -10000 0 0
SGK1 -0.005 0.002 -10000 0 -10000 0 0
mol:cAMP 0 0 -10000 0 -10000 0 0
PTPN11 0.032 0.003 -10000 0 -10000 0 0
IRS1 0.032 0.009 -10000 0 -0.063 4 4
p62DOK/RasGAP 0.033 0.044 -10000 0 -10000 0 0
INS 0.035 0.013 0.078 32 -10000 0 32
mol:PI-3-4-P2 -0.018 0.013 0.032 26 -10000 0 26
GRB2 0.032 0.006 -10000 0 -10000 0 0
EIF4EBP1 -0.041 0.046 0.35 2 -10000 0 2
PTPRA 0.031 0.01 0.07 1 -10000 0 1
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
TC10/GTP/CIP4 0.042 0.012 -10000 0 -0.04 6 6
PDPK1 0.032 0.004 -10000 0 -10000 0 0
Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos 0.014 0.028 -10000 0 -0.11 17 17
Insulin Receptor/Insulin/IRS1 0.06 0.025 -10000 0 -0.035 21 21
Insulin Receptor/Insulin/IRS3 0.049 0.018 0.11 20 -10000 0 20
Par3/Par6 0.07 0.026 -10000 0 -10000 0 0
Reelin signaling pathway

Figure S112.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S112.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDK5R1/CDK5 0.025 0.024 -10000 0 -10000 0 0
VLDLR 0.029 0.012 -10000 0 -0.063 3 3
CRKL 0.031 0.007 -10000 0 -10000 0 0
LRPAP1 0.032 0.003 -10000 0 -10000 0 0
FYN 0.029 0.011 -10000 0 -0.063 1 1
ITGA3 0.029 0.017 -10000 0 -0.063 17 17
RELN/VLDLR/Fyn 0.017 0.031 -10000 0 -0.046 6 6
MAPK8IP1/MKK7/MAP3K11/JNK1 0.061 0.06 -10000 0 -10000 0 0
AKT1 -0.004 0.029 -10000 0 -0.13 24 24
MAP2K7 0.031 0.006 -10000 0 -10000 0 0
RAPGEF1 0.031 0.006 -10000 0 -10000 0 0
DAB1 0.032 0.005 -10000 0 -10000 0 0
RELN/LRP8/DAB1 0.02 0.03 -10000 0 -0.041 3 3
LRPAP1/LRP8 0.047 0.009 -10000 0 -10000 0 0
RELN/LRP8/DAB1/Fyn 0.022 0.036 -10000 0 -10000 0 0
DAB1/alpha3/beta1 Integrin 0.017 0.038 -10000 0 -10000 0 0
long-term memory 0.016 0.035 0.17 2 -10000 0 2
DAB1/LIS1 0.026 0.045 -10000 0 -10000 0 0
DAB1/CRLK/C3G 0.02 0.038 -10000 0 -10000 0 0
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
DAB1/NCK2 0.027 0.046 -10000 0 -10000 0 0
ARHGEF2 0.032 0.005 -10000 0 -10000 0 0
mol:Src family inhibitors PP1 and PP2 0 0 -10000 0 -10000 0 0
GRIN2A 0.021 0.015 -10000 0 -10000 0 0
CDK5R1 0.026 0.013 -10000 0 -10000 0 0
RELN 0.01 0.016 -10000 0 -0.063 2 2
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
RELN/LRP8/Fyn 0.018 0.031 -10000 0 -0.048 2 2
GRIN2A/RELN/LRP8/DAB1/Fyn 0.021 0.041 -10000 0 -10000 0 0
MAPK8 0.025 0.014 -10000 0 -10000 0 0
RELN/VLDLR/DAB1 0.018 0.03 -10000 0 -0.043 3 3
ITGB1 0.025 0.014 -10000 0 -10000 0 0
MAP1B 0.008 0.05 0.15 55 -10000 0 55
RELN/LRP8 0.02 0.031 -10000 0 -0.048 2 2
GRIN2B/RELN/LRP8/DAB1/Fyn 0.025 0.045 -10000 0 -10000 0 0
PI3K 0.039 0.023 -10000 0 -0.05 16 16
mol:PP2 0 0 -10000 0 -10000 0 0
alpha3/beta1 Integrin 0.034 0.025 -10000 0 -0.05 15 15
RAP1A 0.052 0.092 0.31 17 -10000 0 17
PAFAH1B1 0.032 0.006 -10000 0 -10000 0 0
MAPK8IP1 0.032 0.006 -10000 0 -10000 0 0
CRLK/C3G 0.044 0.014 -10000 0 -10000 0 0
GRIN2B 0.031 0.007 -10000 0 -10000 0 0
NCK2 0.032 0.004 -10000 0 -10000 0 0
neuron differentiation -0.016 0.059 -10000 0 -0.17 41 41
neuron adhesion 0.039 0.091 0.31 18 -10000 0 18
LRP8 0.032 0.005 -10000 0 -10000 0 0
GSK3B -0.003 0.039 0.077 46 -0.14 24 70
RELN/VLDLR/DAB1/Fyn 0.02 0.036 -10000 0 -10000 0 0
MAP3K11 0.032 0.004 -10000 0 -10000 0 0
RELN/VLDLR/DAB1/P13K 0.004 0.018 -10000 0 -0.1 9 9
CDK5 0.021 0.016 -10000 0 -10000 0 0
MAPT 0.004 0.056 0.72 1 -10000 0 1
neuron migration -0.015 0.08 0.19 44 -0.16 13 57
RELN/LRP8/DAB1/Fyn/MAPK8IP1/MKK7/MAP3K11/JNK1 -0.016 0.06 -10000 0 -0.17 41 41
RELN/VLDLR 0.024 0.04 -10000 0 -10000 0 0
Signaling mediated by p38-gamma and p38-delta

Figure S113.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S113.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EEF2K -0.018 0.005 -10000 0 -0.039 15 15
SNTA1 0.03 0.009 -10000 0 -10000 0 0
response to hypoxia 0 0 -10000 0 -10000 0 0
STMN1 -0.026 0.007 -10000 0 -0.048 15 15
MAPK12 -0.011 0.017 0.2 3 -10000 0 3
CCND1 -0.007 0.046 -10000 0 -0.35 7 7
p38 gamma/SNTA1 -0.016 0.024 0.19 4 -10000 0 4
MAP2K3 0.032 0.004 -10000 0 -10000 0 0
PKN1 0.03 0.013 -10000 0 -0.063 8 8
G2/M transition checkpoint -0.011 0.017 0.2 3 -10000 0 3
MAP2K6 -0.007 0.004 -10000 0 -0.038 8 8
MAPT -0.025 0.045 0.14 3 -0.14 16 19
MAPK13 -0.023 0.006 -10000 0 -0.05 15 15
hyperosmotic response 0 0 -10000 0 -10000 0 0
ZAK 0.012 0.007 -10000 0 -0.036 8 8
IL4-mediated signaling events

Figure S114.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S114.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.054 0.16 0.45 1 -0.68 2 3
STAT6 (cleaved dimer) -0.051 0.14 -10000 0 -0.7 2 2
IGHG1 -0.022 0.084 -10000 0 -0.49 1 1
IGHG3 -0.063 0.14 -10000 0 -0.66 2 2
AKT1 -0.022 0.11 -10000 0 -0.62 3 3
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 0.001 0.079 -10000 0 -0.5 2 2
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 -0.015 0.1 -10000 0 -0.63 1 1
THY1 -0.17 0.31 -10000 0 -0.7 89 89
MYB 0.029 0.014 -10000 0 -0.063 7 7
HMGA1 0.032 0.002 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3 -0.025 0.11 -10000 0 -0.64 1 1
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP -0.019 0.1 -10000 0 -0.64 1 1
SP1 -0.005 0.04 -10000 0 -0.056 30 30
INPP5D 0 0 -10000 0 -10000 0 0
SOCS5 0.031 0.017 -10000 0 -10000 0 0
STAT6 (dimer)/ETS1 -0.045 0.15 -10000 0 -0.72 1 1
SOCS1 -0.044 0.13 0.29 1 -0.53 1 2
SOCS3 -0.03 0.095 -10000 0 -0.55 1 1
FCER2 -0.046 0.13 -10000 0 -0.62 2 2
PARP14 0.001 0 -10000 0 -10000 0 0
CCL17 -0.069 0.15 -10000 0 -0.68 2 2
GRB2 0.032 0.006 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP -0.018 0.086 -10000 0 -0.58 1 1
T cell proliferation -0.057 0.15 -10000 0 -0.85 1 1
IL4R/JAK1 -0.06 0.16 -10000 0 -0.68 1 1
EGR2 -0.071 0.15 -10000 0 -0.69 2 2
JAK2 0.009 0.038 -10000 0 -10000 0 0
JAK3 0.032 0.013 -10000 0 -10000 0 0
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
JAK1 0.019 0.026 -10000 0 -10000 0 0
COL1A2 -0.054 0.11 -10000 0 -0.72 5 5
CCL26 -0.066 0.15 -10000 0 -0.68 2 2
IL4R -0.07 0.16 -10000 0 -0.72 1 1
PTPN6 0.03 0.017 -10000 0 -0.047 17 17
IL13RA2 -0.088 0.15 -10000 0 -0.7 1 1
IL13RA1 0.001 0.05 -10000 0 -0.1 5 5
IRF4 0.012 0.065 -10000 0 -0.45 3 3
ARG1 -0.021 0.091 -10000 0 -0.41 2 2
CBL -0.03 0.1 0.29 1 -0.61 1 2
GTF3A 0.023 0.026 -10000 0 -0.043 63 63
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
IL13RA1/JAK2 0.005 0.055 -10000 0 -10000 0 0
IRF4/BCL6 0.02 0.068 -10000 0 -0.43 3 3
CD40LG 0.035 0.004 -10000 0 -10000 0 0
MAPK14 -0.03 0.1 -10000 0 -0.61 1 1
mitosis -0.019 0.11 -10000 0 -0.58 3 3
STAT6 -0.069 0.16 -10000 0 -0.75 2 2
SPI1 0.032 0.013 -10000 0 -0.061 8 8
RPS6KB1 -0.023 0.11 -10000 0 -0.57 3 3
STAT6 (dimer) -0.068 0.17 -10000 0 -0.74 2 2
STAT6 (dimer)/PARP14 -0.069 0.15 -10000 0 -0.71 2 2
mast cell activation 0.003 0.007 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/DOK2 -0.014 0.092 -10000 0 -0.63 1 1
FRAP1 -0.02 0.12 -10000 0 -0.61 3 3
LTA -0.07 0.15 -10000 0 -0.7 2 2
FES 0.032 0.004 -10000 0 -10000 0 0
T-helper 1 cell differentiation 0.069 0.16 0.74 2 -10000 0 2
CCL11 -0.067 0.14 -10000 0 -0.66 2 2
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES -0.011 0.097 -10000 0 -0.88 1 1
IL2RG 0.03 0.019 -10000 0 -0.06 10 10
IL10 -0.064 0.16 -10000 0 -0.68 2 2
IRS1 0.032 0.009 -10000 0 -0.063 4 4
IRS2 0.03 0.008 -10000 0 -10000 0 0
IL4 -0.01 0.085 -10000 0 -0.56 6 6
IL5 -0.069 0.15 -10000 0 -0.68 2 2
IL4/IL4R/JAK1/IL13RA1/JAK2 -0.067 0.16 -10000 0 -0.71 2 2
COL1A1 -0.04 0.12 -10000 0 -0.6 10 10
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
IL4/IL4R/JAK1 -0.062 0.16 -10000 0 -0.71 1 1
IL2R gamma/JAK3 0.048 0.018 -10000 0 -0.048 10 10
TFF3 -0.069 0.15 -10000 0 -0.7 1 1
ALOX15 -0.07 0.15 -10000 0 -0.68 2 2
MYBL1 0.017 0.034 -10000 0 -0.063 78 78
T-helper 2 cell differentiation -0.053 0.14 -10000 0 -0.78 2 2
SHC1 0.024 0.026 -10000 0 -0.063 40 40
CEBPB 0.03 0.016 -10000 0 -0.061 11 11
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 -0.021 0.1 -10000 0 -0.68 2 2
mol:PI-3-4-5-P3 -0.02 0.12 -10000 0 -0.61 3 3
PI3K -0.021 0.12 -10000 0 -0.65 3 3
DOK2 0 0 -10000 0 -10000 0 0
ETS1 0.033 0.013 -10000 0 -0.033 9 9
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 -0.016 0.083 -10000 0 -0.52 1 1
ITGB3 -0.069 0.15 -10000 0 -0.68 2 2
PIGR -0.064 0.16 -10000 0 -0.68 2 2
IGHE 0.014 0.04 0.14 24 -0.096 3 27
MAPKKK cascade -0.016 0.082 -10000 0 -0.52 1 1
BCL6 0.028 0.017 -10000 0 -0.063 15 15
OPRM1 -0.069 0.15 -10000 0 -0.68 2 2
RETNLB -0.066 0.15 -10000 0 -0.68 2 2
SELP -0.066 0.15 -10000 0 -0.68 2 2
AICDA -0.063 0.15 0.41 1 -0.68 2 3
Ephrin B reverse signaling

Figure S115.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S115.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EFNB2 0.03 0.01 -10000 0 -10000 0 0
EPHB2 0.031 0.007 -10000 0 -0.064 1 1
EFNB1 -0.004 0.009 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
Rac1/GDP 0.009 0.026 -10000 0 -10000 0 0
Ephrin B2/EPHB1-2 0.05 0.03 -10000 0 -0.036 31 31
neuron projection morphogenesis 0.006 0.018 -10000 0 -10000 0 0
Ephrin B1/EPHB1-2/Tiam1 0.011 0.026 0.16 1 -10000 0 1
DNM1 0.006 0.012 -10000 0 -10000 0 0
cell-cell signaling -0.001 0.002 -10000 0 -10000 0 0
MAP2K4 -0.007 0.037 0.2 1 -0.38 4 5
YES1 0.008 0.061 -10000 0 -0.61 4 4
Ephrin B1/EPHB1-2/NCK2 0.011 0.026 0.16 1 -10000 0 1
PI3K 0.039 0.048 -10000 0 -0.32 5 5
mol:GDP 0.01 0.025 0.16 1 -10000 0 1
ITGA2B 0.032 0.003 -10000 0 -10000 0 0
endothelial cell proliferation 0.027 0.021 -10000 0 -10000 0 0
FYN 0.01 0.063 -10000 0 -0.61 4 4
MAP3K7 -0.001 0.032 -10000 0 -0.39 3 3
FGR 0.013 0.057 -10000 0 -0.6 4 4
TIAM1 0.031 0.008 -10000 0 -10000 0 0
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
RGS3 0.031 0.007 -10000 0 -0.063 1 1
cell adhesion 0.02 0.042 -10000 0 -0.34 4 4
LYN 0.01 0.058 -10000 0 -0.6 4 4
Ephrin B1/EPHB1-2/Src Family Kinases 0.007 0.054 -10000 0 -0.57 4 4
Ephrin B1/EPHB1-2 0.006 0.036 -10000 0 -0.42 3 3
SRC 0.013 0.058 -10000 0 -0.6 4 4
ITGB3 0.032 0.003 -10000 0 -10000 0 0
EPHB1 0.03 0.013 -10000 0 -0.061 9 9
EPHB4 0.023 0.015 -10000 0 -10000 0 0
RAC1 0.023 0.015 -10000 0 -10000 0 0
Ephrin B2/EPHB4 0.028 0.021 -10000 0 -10000 0 0
alphaIIb/beta3 Integrin 0.048 0.005 -10000 0 -10000 0 0
BLK 0.014 0.058 -10000 0 -0.58 4 4
HCK 0.01 0.057 -10000 0 -0.58 4 4
regulation of stress fiber formation -0.011 0.025 -10000 0 -0.16 1 1
MAPK8 -0.008 0.04 0.2 2 -0.38 4 6
Ephrin B1/EPHB1-2/RGS3 0.011 0.025 -10000 0 -10000 0 0
endothelial cell migration 0.047 0.095 0.19 136 -0.33 3 139
NCK2 0.032 0.004 -10000 0 -10000 0 0
PTPN13 0.027 0.023 -10000 0 -0.073 24 24
regulation of focal adhesion formation -0.011 0.025 -10000 0 -0.16 1 1
chemotaxis -0.01 0.025 -10000 0 -10000 0 0
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
Rac1/GTP 0.008 0.022 -10000 0 -10000 0 0
angiogenesis 0.005 0.041 -10000 0 -0.42 4 4
LCK 0.013 0.058 -10000 0 -0.6 4 4
Calcium signaling in the CD4+ TCR pathway

Figure S116.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S116.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC1 -0.017 0.007 -10000 0 -10000 0 0
NFATC2 -0.01 0.004 -10000 0 -10000 0 0
NFATC3 -0.017 0.007 -10000 0 -10000 0 0
CD40LG -0.038 0.044 0.23 6 -10000 0 6
PTGS2 -0.04 0.039 0.19 4 -10000 0 4
JUNB 0.03 0.013 -10000 0 -0.063 8 8
CaM/Ca2+/Calcineurin A alpha-beta B1 0.021 0.009 -10000 0 -0.02 4 4
CaM/Ca2+ 0.021 0.009 -10000 0 -0.02 4 4
CALM1 0.029 0.01 -10000 0 -10000 0 0
JUN 0.032 0.005 -10000 0 -10000 0 0
mol:Ca2+ -0.001 0.001 -10000 0 -10000 0 0
Calcineurin A alpha-beta B1/FKBP12/FK506 0.02 0.006 -10000 0 -0.031 1 1
FOSL1 0.03 0.015 -10000 0 -0.063 12 12
CREM 0.025 0.013 -10000 0 -10000 0 0
Jun/NFAT1-c-4/p21SNFT 0.024 0.032 -10000 0 -10000 0 0
FOS 0.007 0.04 -10000 0 -0.064 120 120
IFNG -0.037 0.039 0.34 1 -10000 0 1
AP-1/NFAT1-c-4 0.032 0.073 0.2 4 -0.12 1 5
FASLG -0.039 0.039 0.3 1 -10000 0 1
NFAT1-c-4/ICER1 0.003 0.036 -10000 0 -10000 0 0
IL2RA -0.029 0.042 0.32 2 -10000 0 2
FKBP12/FK506 0.022 0.007 -10000 0 -0.039 1 1
CSF2 -0.039 0.041 0.21 5 -10000 0 5
JunB/Fra1/NFAT1-c-4 0.032 0.041 0.15 7 -10000 0 7
IL4 -0.038 0.041 0.29 2 -10000 0 2
IL2 0.016 0.088 -10000 0 -0.86 5 5
IL3 0.027 0.073 -10000 0 -0.59 7 7
FKBP1A 0.03 0.009 -10000 0 -0.063 1 1
BATF3 0 0 -10000 0 -10000 0 0
mol:FK506 0 0 -10000 0 -10000 0 0
POU2F1 0.034 0.005 -10000 0 -10000 0 0
IGF1 pathway

Figure S117.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S117.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NCK2 0.032 0.004 -10000 0 -10000 0 0
PTK2 0.031 0.006 -10000 0 -10000 0 0
CRKL -0.021 0.007 -10000 0 -10000 0 0
GRB2/SOS1/SHC 0.035 0.024 -10000 0 -0.04 40 40
HRAS 0.031 0.007 -10000 0 -10000 0 0
IRS1/Crk 0.024 0.013 -10000 0 -0.058 9 9
IGF-1R heterotetramer/IGF1/PTP1B 0.057 0.022 -10000 0 -0.048 9 9
AKT1 -0.022 0.044 0.17 17 -10000 0 17
BAD -0.027 0.042 0.15 17 -10000 0 17
mol:GTP 0 0 -10000 0 -10000 0 0
CRK -0.022 0.006 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1/Shp2 0.032 0.015 -10000 0 -0.072 6 6
RAF1 -0.007 0.054 0.24 3 -0.43 3 6
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos 0.053 0.019 -10000 0 -0.067 6 6
YWHAZ 0.032 0.006 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1 0.04 0.015 -10000 0 -0.07 6 6
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
RPS6KB1 -0.024 0.045 0.17 18 -10000 0 18
GNB2L1 0.032 0.004 -10000 0 -10000 0 0
positive regulation of MAPKKK cascade -0.011 0.055 0.23 7 -0.35 3 10
PXN 0.032 0.003 -10000 0 -10000 0 0
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
cell adhesion 0 0 -10000 0 -10000 0 0
GRB2/SOS1 0.023 0.004 -10000 0 -10000 0 0
HRAS/GTP 0.023 0.028 -10000 0 -0.071 6 6
IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc 0.061 0.039 -10000 0 -0.061 1 1
IGF-1R heterotetramer 0.034 0.008 0.098 1 -0.031 5 6
IGF-1R heterotetramer/IGF1/IRS/Nck 0.058 0.019 -10000 0 -0.071 6 6
Crk/p130 Cas/Paxillin 0.047 0.018 0.21 1 -0.072 6 7
IGF1R 0.034 0.008 0.098 1 -0.031 5 6
IGF1 0.033 0.012 -10000 0 -0.052 9 9
IRS2/Crk -0.025 0.009 -10000 0 -10000 0 0
PI3K 0.062 0.037 -10000 0 -0.074 4 4
apoptosis 0.027 0.051 -10000 0 -0.16 22 22
HRAS/GDP 0.023 0.005 -10000 0 -10000 0 0
PRKCD 0.002 0.018 -10000 0 -0.14 4 4
RAF1/14-3-3 E -0.006 0.058 0.27 4 -0.38 3 7
BAD/14-3-3 -0.028 0.053 0.17 22 -10000 0 22
PRKCZ -0.018 0.043 0.16 19 -10000 0 19
Crk/p130 Cas/Paxillin/FAK1 -0.037 0.04 0.12 16 -10000 0 16
PTPN1 0.03 0.009 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 0.01 0.022 -10000 0 -0.15 5 5
BCAR1 0 0 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/SHC/GRB10 0.044 0.047 -10000 0 -0.07 2 2
mol:GDP 0 0 -10000 0 -10000 0 0
SOS1 0 0 -10000 0 -10000 0 0
IRS1/NCK2 0.033 0.017 0.13 4 -0.071 6 10
GRB10 0.021 0.018 -10000 0 -0.063 6 6
PTPN11 -0.022 0.006 -10000 0 -10000 0 0
IRS1 -0.016 0.014 0.12 4 -10000 0 4
IRS2 -0.021 0.008 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1 0.045 0.011 -10000 0 -0.054 4 4
GRB2 0.032 0.006 -10000 0 -10000 0 0
PDPK1 -0.019 0.046 0.18 19 -10000 0 19
YWHAE 0.032 0.005 -10000 0 -10000 0 0
PRKD1 -0.003 0.021 -10000 0 -0.13 8 8
SHC1 0.024 0.026 -10000 0 -0.063 40 40
p38 MAPK signaling pathway

Figure S118.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S118.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TRAF6/ASK1 0.021 0.017 -10000 0 -0.1 8 8
TRAF2/ASK1 0.039 0.014 -10000 0 -10000 0 0
ATM 0.027 0.021 -10000 0 -0.063 25 25
MAP2K3 0.028 0.059 0.19 4 -0.26 10 14
response to stress 0 0 -10000 0 -10000 0 0
MAP2K6 0.025 0.056 0.2 6 -0.21 12 18
hyperosmotic response 0 0 -10000 0 -10000 0 0
response to oxidative stress 0 0 -10000 0 -10000 0 0
GADD45G 0.029 0.015 -10000 0 -0.063 12 12
TXN 0.006 0.001 -10000 0 -10000 0 0
CALM1 0.029 0.01 -10000 0 -10000 0 0
GADD45A 0.024 0.026 -10000 0 -0.063 39 39
GADD45B 0.03 0.013 -10000 0 -0.063 8 8
MAP3K1 0.032 0.006 -10000 0 -0.063 1 1
MAP3K6 0.031 0.008 -10000 0 -0.063 2 2
MAP3K7 0.031 0.008 -10000 0 -0.063 1 1
MAP3K4 0.03 0.008 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
ASK1/ASK2 0.043 0.016 -10000 0 -0.05 2 2
TAK1/TAB family 0.002 0.023 0.074 42 -0.069 7 49
RAC1/OSM/MEKK3 0.029 0.02 -10000 0 -0.023 3 3
TRAF2 0.031 0.006 -10000 0 -10000 0 0
RAC1/OSM/MEKK3/MKK3 0.021 0.048 -10000 0 -0.21 11 11
TRAF6 0.006 0.001 -10000 0 -10000 0 0
RAC1 0.023 0.015 -10000 0 -10000 0 0
mol:LPS 0 0 -10000 0 -10000 0 0
CAMK2B 0.003 0.009 -10000 0 -10000 0 0
CCM2 0 0 -10000 0 -10000 0 0
CaM/Ca2+/CAMKIIB 0.004 0.013 -10000 0 -10000 0 0
MAPK11 0.029 0.01 -10000 0 -10000 0 0
response to DNA damage stimulus 0 0 -10000 0 -10000 0 0
CaM/Ca2+/CAMKIIB/ASK1 0.005 0.018 -10000 0 -0.031 2 2
OSM/MEKK3 0.024 0.002 -10000 0 0 5 5
TAOK1 0.004 0.009 -10000 0 -0.037 25 25
TAOK2 0.01 0.011 -10000 0 -0.036 25 25
TAOK3 0.01 0.011 -10000 0 -0.036 25 25
MAP3K7IP1 0 0 -10000 0 -10000 0 0
MAPK14 0.032 0.005 -10000 0 -0.063 1 1
MAP3K7IP2 0 0 -10000 0 -10000 0 0
MAP3K5 0.03 0.009 -10000 0 -10000 0 0
MAP3K10 0.031 0.006 -10000 0 -10000 0 0
MAP3K3 0.032 0.003 -10000 0 -10000 0 0
TRX/ASK1 0.025 0.016 -10000 0 -0.11 5 5
GADD45/MTK1/MTK1 0.052 0.047 -10000 0 -0.056 7 7
Regulation of Androgen receptor activity

Figure S119.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S119.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 -0.014 0.009 0 13 -0.039 61 74
SMARCC1 0.004 0.02 -10000 0 -10000 0 0
REL 0.032 0.002 -10000 0 -10000 0 0
HDAC7 -0.036 0.03 0.16 2 -0.16 1 3
JUN 0.032 0.005 -10000 0 -10000 0 0
EP300 0.03 0.008 -10000 0 -10000 0 0
KAT2B 0 0 -10000 0 -10000 0 0
KAT5 0 0 -10000 0 -10000 0 0
MAPK14 -0.021 0.011 0.019 29 -0.051 1 30
FOXO1 0.028 0.016 -10000 0 -0.063 11 11
T-DHT/AR 0.01 0.052 0.21 2 -0.15 2 4
MAP2K6 0.032 0.004 -10000 0 -10000 0 0
BRM/BAF57 0.043 0.015 -10000 0 -10000 0 0
MAP2K4 0.031 0.008 -10000 0 -10000 0 0
SMARCA2 0.029 0.01 -10000 0 -10000 0 0
PDE9A 0.014 0.063 -10000 0 -0.5 7 7
NCOA2 0.032 0.004 -10000 0 -10000 0 0
CEBPA 0.028 0.017 -10000 0 -0.063 15 15
EHMT2 0.033 0.003 -10000 0 -10000 0 0
cell proliferation -0.022 0.075 0.24 9 -0.24 21 30
NR0B1 0.024 0.027 -10000 0 -0.063 46 46
EGR1 0.029 0.017 -10000 0 -0.062 15 15
RXRs/9cRA 0.058 0.021 -10000 0 -0.041 4 4
AR/RACK1/Src -0.023 0.052 0.17 12 -0.15 1 13
AR/GR 0.003 0.044 0.14 3 -0.19 7 10
GNB2L1 0.032 0.004 -10000 0 -10000 0 0
PKN1 0.03 0.013 -10000 0 -0.063 8 8
RCHY1 0.032 0.004 -10000 0 -10000 0 0
epidermal growth factor receptor activity 0 0 -10000 0 -10000 0 0
MAPK8 -0.016 0.012 0.019 15 -10000 0 15
T-DHT/AR/TIF2/CARM1 -0.03 0.044 0.2 7 -0.15 1 8
SRC -0.024 0.025 0.18 4 -10000 0 4
NR3C1 0.032 0.004 -10000 0 -10000 0 0
KLK3 -0.02 0.062 -10000 0 -0.41 3 3
APPBP2 0.033 0.004 -10000 0 -10000 0 0
TRIM24 0.022 0.016 -10000 0 -0.062 2 2
T-DHT/AR/TIP60 -0.029 0.021 0.042 3 -0.087 14 17
TMPRSS2 0.013 0.068 -10000 0 -0.5 8 8
RXRG 0.032 0.008 -10000 0 -0.063 3 3
mol:9cRA 0 0 -10000 0 -10000 0 0
RXRA 0.031 0.007 -10000 0 -10000 0 0
RXRB 0.032 0.003 -10000 0 -10000 0 0
CARM1 0.032 0.006 -10000 0 -10000 0 0
NR2C2 0.032 0.004 -10000 0 -10000 0 0
KLK2 -0.016 0.045 0.16 7 -0.18 13 20
AR -0.003 0.019 0.14 5 -0.16 2 7
SENP1 0 0 -10000 0 -10000 0 0
HSP90AA1 0.03 0.008 -10000 0 -10000 0 0
MDM2 0.029 0.011 -10000 0 -0.063 1 1
SRY 0 0 -10000 0 -10000 0 0
GATA2 0.032 0.005 -10000 0 -10000 0 0
MYST2 0 0 -10000 0 -10000 0 0
HOXB13 0.033 0.003 -10000 0 -10000 0 0
T-DHT/AR/RACK1/Src -0.024 0.053 0.18 12 -0.16 1 13
positive regulation of transcription 0.032 0.005 -10000 0 -10000 0 0
DNAJA1 0.03 0.01 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.01 0.019 -10000 0 -0.2 3 3
NCOA1 0.032 0.02 0.11 4 -10000 0 4
SPDEF 0.033 0.003 -10000 0 -10000 0 0
T-DHT/AR/TIF2 -0.035 0.082 0.15 6 -0.24 47 53
T-DHT/AR/Hsp90 -0.028 0.037 0.18 6 -0.16 1 7
GSK3B 0.032 0.006 -10000 0 -10000 0 0
NR2C1 0.032 0.004 -10000 0 -10000 0 0
mol:T-DHT -0.022 0.015 -10000 0 -10000 0 0
SIRT1 0.025 0.014 -10000 0 -10000 0 0
ZMIZ2 0.022 0.015 -10000 0 -10000 0 0
POU2F1 0.036 0.01 -10000 0 -10000 0 0
T-DHT/AR/DAX-1 -0.033 0.037 0.18 6 -0.15 1 7
CREBBP 0.032 0.004 -10000 0 -10000 0 0
SMARCE1 0.032 0.004 -10000 0 -10000 0 0
RXR and RAR heterodimerization with other nuclear receptor

Figure S120.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S120.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 -0.011 0.06 0.32 14 -10000 0 14
VDR 0.031 0.006 -10000 0 -10000 0 0
FAM120B 0 0 -10000 0 -10000 0 0
RXRs/LXRs/DNA/9cRA -0.023 0.039 -10000 0 -0.15 17 17
RXRs/LXRs/DNA/Oxysterols -0.03 0.046 -10000 0 -0.17 15 15
MED1 0.032 0.004 -10000 0 -10000 0 0
mol:9cRA -0.006 0.005 -10000 0 -10000 0 0
RARs/THRs/DNA/Src-1 0.02 0.035 -10000 0 -0.16 17 17
RXRs/NUR77 0.059 0.031 -10000 0 -10000 0 0
RXRs/PPAR 0.003 0.046 -10000 0 -0.12 56 56
NCOR2 0.032 0.004 -10000 0 -10000 0 0
VDR/VDR/Vit D3 0.023 0.005 -10000 0 -10000 0 0
RARs/VDR/DNA/Vit D3 0.07 0.026 -10000 0 -10000 0 0
RARA 0.032 0.004 -10000 0 -10000 0 0
NCOA1 0.031 0.007 -10000 0 -10000 0 0
VDR/VDR/DNA 0.031 0.006 -10000 0 -10000 0 0
RARs/RARs/DNA/9cRA 0.051 0.016 -10000 0 -10000 0 0
RARG 0.032 0.005 -10000 0 -10000 0 0
RPS6KB1 -0.012 0.059 0.56 5 -10000 0 5
RARs/THRs/DNA/SMRT 0.023 0.032 -10000 0 -0.17 12 12
THRA 0.032 0.004 -10000 0 -10000 0 0
mol:Bile acids 0 0 -10000 0 -10000 0 0
VDR/Vit D3/DNA 0.023 0.005 -10000 0 -10000 0 0
RXRs/PPAR/9cRA/PGJ2/DNA -0.011 0.053 -10000 0 -10000 0 0
NR1H4 0.032 0.004 -10000 0 -10000 0 0
RXRs/LXRs/DNA -0.016 0.073 -10000 0 -10000 0 0
NR1H2 -0.008 0.027 -10000 0 -10000 0 0
NR1H3 -0.01 0.028 -10000 0 -0.066 4 4
RXRs/VDR/DNA/Vit D3 0.053 0.031 -10000 0 -10000 0 0
NR4A1 0.032 0.006 -10000 0 -10000 0 0
mol:ATRA 0 0 -10000 0 -10000 0 0
RXRs/FXR/9cRA/MED1 -0.004 0.028 0.085 5 -0.12 16 21
RXRG -0.007 0.029 -10000 0 -0.069 3 3
RXR alpha/CCPG 0.019 0.007 -10000 0 -10000 0 0
RXRA -0.007 0.028 -10000 0 -10000 0 0
RXRB -0.008 0.029 -10000 0 -0.04 1 1
THRB 0.032 0.004 -10000 0 -10000 0 0
PPARG 0.031 0.009 -10000 0 -0.063 4 4
PPARD 0.032 0.002 -10000 0 -10000 0 0
TNF -0.032 0.041 -10000 0 -0.15 18 18
mol:Oxysterols -0.005 0.004 -10000 0 -10000 0 0
cholesterol transport -0.03 0.046 -10000 0 -0.17 15 15
PPARA 0.03 0.009 -10000 0 -10000 0 0
mol:Vit D3 0 0 -10000 0 -10000 0 0
RARB 0.032 0.004 -10000 0 -10000 0 0
RXRs/NUR77/BCL2 0.011 0.032 -10000 0 -0.12 27 27
SREBF1 -0.031 0.041 -10000 0 -0.16 17 17
RXRs/RXRs/DNA/9cRA -0.011 0.053 -10000 0 -10000 0 0
ABCA1 -0.059 0.056 -10000 0 -0.19 17 17
RARs/THRs 0.091 0.027 -10000 0 -10000 0 0
RXRs/FXR 0.06 0.029 -10000 0 -10000 0 0
BCL2 0.032 0.006 -10000 0 0 17 17
Signaling events mediated by HDAC Class II

Figure S121.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S121.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
G beta1gamma2/HDAC5 0.056 0.023 -10000 0 -0.039 3 3
HDAC3 0.032 0.004 -10000 0 -10000 0 0
Ran/GTP/Exportin 1/HDAC4 -0.025 0.003 -10000 0 -10000 0 0
GATA1/HDAC4 0.048 0.006 -10000 0 -10000 0 0
GATA1/HDAC5 0.048 0.006 -10000 0 -10000 0 0
GATA2/HDAC5 0.047 0.009 -10000 0 -10000 0 0
HDAC5/BCL6/BCoR 0.058 0.028 -10000 0 -0.044 31 31
HDAC9 0.022 0.016 -10000 0 -0.063 2 2
Glucocorticoid receptor/Hsp90/HDAC6 0.059 0.027 -10000 0 -0.044 3 3
HDAC4/ANKRA2 0.047 0.009 -10000 0 -0.05 1 1
HDAC5/YWHAB 0.044 0.014 -10000 0 -10000 0 0
NPC/RanGAP1/SUMO1/Ubc9 0.003 0.028 -10000 0 -0.095 39 39
GATA2 0.032 0.005 -10000 0 -10000 0 0
HDAC4/RFXANK 0.038 0.029 -10000 0 -0.05 45 45
BCOR 0.032 0.01 -10000 0 -0.063 5 5
mol:GTP 0 0 -10000 0 -10000 0 0
HDAC10 0 0 -10000 0 -10000 0 0
HDAC5 0.032 0.003 -10000 0 -10000 0 0
GNB1/GNG2 0.023 0.006 -10000 0 -10000 0 0
Histones 0.035 0.031 -10000 0 -0.095 3 3
ADRBK1 0.032 0.004 -10000 0 -10000 0 0
HDAC4 0.032 0.003 -10000 0 -10000 0 0
XPO1 0.033 0.001 -10000 0 -10000 0 0
HDAC5/ANKRA2 0.047 0.009 -10000 0 -0.05 1 1
HDAC4/Ubc9 0.048 0.006 -10000 0 -10000 0 0
HDAC7 0 0 -10000 0 -10000 0 0
HDAC5/14-3-3 E 0.047 0.008 -10000 0 -10000 0 0
TUBA1B 0.032 0.006 -10000 0 -10000 0 0
HDAC6 0.032 0.002 -10000 0 -10000 0 0
HDAC5/RFXANK 0.038 0.028 -10000 0 -0.05 43 43
CAMK4 0.032 0.004 -10000 0 -10000 0 0
Tubulin/HDAC6 0.058 0.023 -10000 0 -0.037 11 11
SUMO1 0.033 0.001 -10000 0 -10000 0 0
EntrezGene:9972 0 0 -10000 0 -10000 0 0
YWHAB 0.03 0.009 -10000 0 -10000 0 0
GATA1 0.032 0.002 -10000 0 -10000 0 0
EntrezGene:8021 0 0 -10000 0 -10000 0 0
YWHAE 0.032 0.005 -10000 0 -10000 0 0
NR3C1 0.032 0.004 -10000 0 -10000 0 0
SUMO1/HDAC4 0.038 0.039 -10000 0 -0.097 39 39
SRF 0.032 0.004 -10000 0 -10000 0 0
HDAC4/YWHAB 0.044 0.014 -10000 0 -10000 0 0
Tubulin 0.043 0.015 -10000 0 -10000 0 0
HDAC4/14-3-3 E 0.047 0.009 -10000 0 -10000 0 0
GNB1 0.031 0.008 -10000 0 -10000 0 0
RANGAP1 0.03 0.008 -10000 0 -10000 0 0
BCL6/BCoR 0.043 0.021 -10000 0 -0.05 19 19
HDAC4/HDAC3/SMRT (N-CoR2) 0.063 0.016 -10000 0 -10000 0 0
HDAC4/SRF 0.063 0.018 -10000 0 -10000 0 0
HDAC4/ER alpha 0.045 0.012 -10000 0 -10000 0 0
EntrezGene:23225 0 0 -10000 0 -10000 0 0
positive regulation of chromatin silencing 0.035 0.031 -10000 0 -0.094 3 3
cell motility 0.058 0.023 -10000 0 -0.037 11 11
EntrezGene:23636 0 0 -10000 0 -10000 0 0
UBE2I 0.032 0.003 -10000 0 -10000 0 0
HDAC7/HDAC3 0.024 0.003 -10000 0 -10000 0 0
BCL6 0.029 0.017 -10000 0 -0.063 15 15
HDAC4/CaMK II delta B 0.032 0.003 -10000 0 -10000 0 0
Hsp90/HDAC6 0.045 0.012 -10000 0 -10000 0 0
ESR1 0.031 0.008 -10000 0 -10000 0 0
HDAC6/HDAC11 0.047 0.007 -10000 0 -10000 0 0
Ran/GTP/Exportin 1 0.037 0.039 -10000 0 -0.096 39 39
NPC 0.019 0.001 -10000 0 -10000 0 0
MEF2C 0.027 0.012 -10000 0 -10000 0 0
RAN 0.032 0.004 -10000 0 -10000 0 0
HDAC4/MEF2C 0.077 0.041 -10000 0 -10000 0 0
GNG2 0 0 -10000 0 -10000 0 0
NCOR2 0.032 0.004 -10000 0 -10000 0 0
TUBB2A 0.03 0.009 -10000 0 -10000 0 0
HDAC11 0.032 0.004 -10000 0 -10000 0 0
HSP90AA1 0.03 0.008 -10000 0 -10000 0 0
RANBP2 0.032 0.002 -10000 0 -10000 0 0
ANKRA2 0.032 0.006 -10000 0 -0.063 1 1
RFXANK 0.023 0.027 -10000 0 -0.063 45 45
nuclear import -0.032 0.023 0.11 10 -10000 0 10
ErbB4 signaling events

Figure S122.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S122.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ErbB4/ErbB4/HBEGF/HBEGF 0.031 0.029 -10000 0 -10000 0 0
epithelial cell differentiation 0.011 0.064 -10000 0 -10000 0 0
ITCH 0.031 0.012 -10000 0 -0.052 2 2
WWP1 0.009 0.023 0.21 6 -10000 0 6
FYN 0.029 0.011 -10000 0 -0.063 1 1
EGFR 0.012 0.018 -10000 0 -0.063 6 6
PRL 0.031 0.011 -10000 0 -0.063 6 6
neuron projection morphogenesis -0.022 0.047 0.24 6 -10000 0 6
PTPRZ1 0.018 0.021 -10000 0 -0.063 17 17
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/GRB2/SHC 0.052 0.047 0.23 1 -10000 0 1
ErbB4 CYT2/ErbB4 CYT2/neuregulin 1 beta/neuregulin 1 beta 0.014 0.019 -10000 0 -10000 0 0
ADAM17 0.03 0.017 -10000 0 -0.055 5 5
ErbB4/ErbB4 0.014 0.014 0.12 6 -0.058 2 8
ErbB4/ErbB4/neuregulin 3/neuregulin 3 0.005 0.017 -10000 0 -10000 0 0
NCOR1 0.032 0.004 -10000 0 -10000 0 0
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/Fyn 0.03 0.025 -10000 0 -10000 0 0
GRIN2B -0.012 0.021 0.18 2 -10000 0 2
ErbB4/ErbB2/betacellulin 0.032 0.025 -10000 0 -10000 0 0
STAT1 0.029 0.018 -10000 0 -0.063 18 18
HBEGF 0.032 0.007 -10000 0 -0.063 2 2
PRLR 0.032 0.005 -10000 0 -10000 0 0
E4ICDs/ETO2 0.03 0.028 -10000 0 -10000 0 0
axon guidance -0.006 0.043 0.2 1 -10000 0 1
NEDD4 0.027 0.021 -10000 0 -0.063 14 14
Prolactin receptor/Prolactin receptor/Prolactin 0.046 0.013 -10000 0 -0.05 6 6
CBFA2T3 0.031 0.006 -10000 0 -10000 0 0
ErbB4/ErbB2/HBEGF 0.032 0.025 -10000 0 -10000 0 0
MAPK3 -0.018 0.049 0.18 21 -10000 0 21
STAT1 (dimer) 0.029 0.03 -10000 0 -10000 0 0
MAPK1 -0.016 0.049 0.19 20 -10000 0 20
JAK2 0.029 0.01 -10000 0 -10000 0 0
ErbB4/ErbB2/neuregulin 1 beta 0.012 0.019 -10000 0 -10000 0 0
NRG1 -0.021 0.012 0.026 8 -10000 0 8
NRG3 0 0 -10000 0 -10000 0 0
NRG2 0.032 0.004 -10000 0 -10000 0 0
NRG4 0 0 -10000 0 -10000 0 0
heart development -0.006 0.043 0.2 1 -10000 0 1
neural crest cell migration 0.012 0.019 -10000 0 -10000 0 0
ERBB2 -0.021 0.011 0.033 2 -10000 0 2
WWOX/E4ICDs 0.03 0.028 -10000 0 -10000 0 0
SHC1 0.024 0.026 -10000 0 -0.063 40 40
ErbB4/EGFR/neuregulin 4 0.012 0.021 -10000 0 -10000 0 0
apoptosis -0.015 0.022 -10000 0 -10000 0 0
ErbB4/ErbB4/neuregulin 2 beta/neuregulin 2 beta 0.031 0.029 -10000 0 -10000 0 0
ErbB4/ErbB2/epiregulin 0.031 0.027 -10000 0 -10000 0 0
ErbB4/ErbB4/betacellulin/betacellulin 0.03 0.029 -10000 0 -10000 0 0
ErbB4/ErbB4/HBEGF/HBEGF/Prolactin receptor/Prolactin receptor/Prolactin/JAK2 0.066 0.05 -10000 0 -10000 0 0
MDM2 0.023 0.071 0.25 43 -10000 0 43
ErbB4 JM-B/ErbB4 JM-B/neuregulin 1 beta/neuregulin 1 beta 0.029 0.018 -10000 0 -10000 0 0
STAT5A -0.014 0.045 0.2 3 -10000 0 3
ErbB4/EGFR/neuregulin 1 beta 0.013 0.022 -10000 0 -10000 0 0
DLG4 0.032 0.005 -10000 0 -10000 0 0
GRB2/SHC 0.038 0.028 -10000 0 -0.05 40 40
E4ICDs/TAB2/NCoR1 0.028 0.027 -10000 0 -10000 0 0
STAT5A (dimer) 0.019 0.073 -10000 0 -10000 0 0
MAP3K7IP2 0 0 -10000 0 -10000 0 0
STAT5B (dimer) 0.003 0.057 0.23 1 -10000 0 1
LRIG1 0.028 0.02 -10000 0 -0.063 21 21
EREG 0.031 0.013 -10000 0 -0.063 9 9
BTC 0.032 0.004 -10000 0 -10000 0 0
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta -0.006 0.043 0.18 2 -10000 0 2
ERBB4 0.014 0.014 0.12 6 -0.058 2 8
STAT5B 0.032 0.004 -10000 0 -10000 0 0
YAP1 0.009 0.06 -10000 0 -0.45 7 7
GRB2 0.032 0.006 -10000 0 -10000 0 0
ErbB4/ErbB2/neuregulin 4 0.012 0.019 -10000 0 -10000 0 0
glial cell differentiation -0.027 0.026 -10000 0 -10000 0 0
WWOX 0.032 0.006 -10000 0 -10000 0 0
cell proliferation -0.002 0.03 0.2 1 -0.22 2 3
LPA4-mediated signaling events

Figure S123.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S123.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ADCY4 -0.009 0.001 0 2 -10000 0 2
ADCY5 -0.009 0.001 0 2 -10000 0 2
ADCY6 -0.017 0.003 -10000 0 -10000 0 0
ADCY7 -0.018 0.003 0 11 -0.04 5 16
ADCY1 -0.013 0.008 -10000 0 -10000 0 0
ADCY2 -0.017 0.003 -10000 0 -10000 0 0
ADCY3 -0.009 0.001 0 2 -10000 0 2
ADCY8 -0.017 0.004 -10000 0 -0.04 5 5
PRKCE -0.011 0.001 0 2 -10000 0 2
ADCY9 -0.018 0.002 -10000 0 -10000 0 0
mol:DAG 0 0 -10000 0 -10000 0 0
cAMP biosynthetic process 0.009 0.043 0.18 12 -0.12 1 13
a4b1 and a4b7 Integrin signaling

Figure S124.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S124.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ITGB1 0.025 0.014 -9999 0 -10000 0 0
ITGB7 0.032 0.008 -9999 0 -0.063 2 2
ITGA4 0.031 0.01 -9999 0 -0.063 5 5
alpha4/beta7 Integrin 0.046 0.013 -9999 0 -0.06 5 5
alpha4/beta1 Integrin 0.036 0.022 -9999 0 -0.05 4 4
IL27-mediated signaling events

Figure S125.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S125.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 0.029 0.022 -10000 0 -10000 0 0
CD4-positive alpha-beta T cell lineage commitment 0 0 -10000 0 -10000 0 0
cytokine production during immune response 0.002 0.054 -10000 0 -10000 0 0
IL27/IL27R/JAK1 0.049 0.028 -10000 0 -10000 0 0
TBX21 -0.019 0.067 0.32 13 -10000 0 13
IL12B 0.032 0.004 -10000 0 -10000 0 0
IL12A -0.011 0.002 -10000 0 -10000 0 0
IL6ST 0.032 0.005 -10000 0 -10000 0 0
IL27RA/JAK1 0.024 0.04 -10000 0 -10000 0 0
IL27 -0.001 0.003 -10000 0 -10000 0 0
TYK2 0.031 0.007 -10000 0 -0.026 1 1
T-helper cell lineage commitment 0.046 0.083 -10000 0 -0.29 1 1
T-helper 2 cell differentiation 0.002 0.054 -10000 0 -10000 0 0
T cell proliferation during immune response 0.002 0.054 -10000 0 -10000 0 0
MAPKKK cascade -0.002 0.054 -10000 0 -10000 0 0
STAT3 0.03 0.014 -10000 0 -0.063 10 10
STAT2 0.031 0.006 -10000 0 -10000 0 0
STAT1 0.029 0.018 -10000 0 -0.063 18 18
IL12RB1 0.031 0.007 -10000 0 -10000 0 0
positive regulation of tyrosine phosphorylation of STAT protein 0 0 -10000 0 -10000 0 0
IL12RB2 -0.022 0.061 0.32 12 -10000 0 12
IL27/IL27R/JAK2/TYK2 -0.002 0.055 -10000 0 -10000 0 0
positive regulation of T cell mediated cytotoxicity -0.002 0.054 -10000 0 -10000 0 0
STAT1 (dimer) 0.056 0.035 -10000 0 -10000 0 0
JAK2 0.029 0.01 -10000 0 -10000 0 0
JAK1 0.031 0.006 -10000 0 -10000 0 0
STAT2 (dimer) 0.021 0.068 -10000 0 -10000 0 0
T cell proliferation -0.003 0.034 -10000 0 -10000 0 0
IL12/IL12R/TYK2/JAK2 0.031 0.092 -10000 0 -0.67 8 8
IL17A 0.045 0.083 0.18 2 -0.29 1 3
mast cell activation 0.002 0.054 -10000 0 -10000 0 0
IFNG 0.004 0.022 0.072 1 -0.085 14 15
T cell differentiation -0.001 0.001 -10000 0 -10000 0 0
STAT3 (dimer) 0.02 0.071 -10000 0 -10000 0 0
STAT5A (dimer) 0.022 0.071 -10000 0 -10000 0 0
STAT4 (dimer) 0.014 0.049 -10000 0 -10000 0 0
STAT4 0.019 0.016 -10000 0 -10000 0 0
T cell activation -0.003 0.001 -10000 0 -10000 0 0
IL27R/JAK2/TYK2 0.044 0.038 -10000 0 -10000 0 0
GATA3 0.001 0.076 0.64 7 -10000 0 7
IL18 -0.013 0.008 0 7 -0.039 43 50
positive regulation of mast cell cytokine production 0.02 0.07 -10000 0 -10000 0 0
IL27/EBI3 0.023 0.009 -10000 0 -0.039 3 3
IL27RA 0.003 0.027 0.26 4 -10000 0 4
IL6 0.017 0.027 -10000 0 -10000 0 0
STAT5A 0.032 0.005 -10000 0 -0.063 1 1
monocyte differentiation 0 0 -10000 0 -10000 0 0
IL2 -0.007 0.027 0.32 3 -10000 0 3
IL1B -0.012 0.004 0 2 -0.039 13 15
EBI3 0.032 0.01 -10000 0 -0.063 3 3
TNF -0.011 0.002 0 3 -0.039 2 5
IL23-mediated signaling events

Figure S126.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S126.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CCL2 -0.02 0.15 -10000 0 -0.63 14 14
IL23A 0.007 0.09 -10000 0 -10000 0 0
NF kappa B1 p50/RelA/I kappa B alpha 0.04 0.12 -10000 0 -10000 0 0
positive regulation of T cell mediated cytotoxicity 0.005 0.12 -10000 0 -10000 0 0
ITGA3 0.003 0.1 -10000 0 -10000 0 0
IL17F -0.011 0.084 -10000 0 -10000 0 0
IL12B 0.027 0.03 -10000 0 -10000 0 0
STAT1 (dimer) 0.013 0.12 -10000 0 -10000 0 0
CD4 0.006 0.11 0.4 1 -10000 0 1
IL23 0.026 0.096 -10000 0 -10000 0 0
IL23R 0.004 0.03 0.082 1 -10000 0 1
IL1B 0.007 0.096 -10000 0 -10000 0 0
T-helper cell lineage commitment 0 0 -10000 0 -10000 0 0
IL24 0.006 0.11 -10000 0 -10000 0 0
TYK2 0.022 0.027 -10000 0 -10000 0 0
STAT4 0.019 0.016 -10000 0 -10000 0 0
STAT3 0.03 0.014 -10000 0 -0.063 10 10
IL18RAP 0.033 0.003 -10000 0 -10000 0 0
IL12RB1 0.022 0.027 -10000 0 -10000 0 0
PIK3CA 0.028 0.018 -10000 0 -0.063 17 17
IL12Rbeta1/TYK2 0.041 0.029 -10000 0 -10000 0 0
IL23R/JAK2 0.027 0.046 -10000 0 -10000 0 0
positive regulation of chronic inflammatory response 0.005 0.12 -10000 0 -10000 0 0
natural killer cell activation 0 0.003 -10000 0 -10000 0 0
JAK2 0.024 0.03 -10000 0 -10000 0 0
PIK3R1 0.03 0.009 -10000 0 -10000 0 0
NFKB1 0.032 0.01 -10000 0 -0.066 4 4
RELA 0.033 0.004 -10000 0 -10000 0 0
positive regulation of dendritic cell antigen processing and presentation 0.026 0.095 -10000 0 -10000 0 0
ALOX12B 0.001 0.11 -10000 0 -10000 0 0
CXCL1 0 0.11 -10000 0 -10000 0 0
T cell proliferation 0.005 0.12 -10000 0 -10000 0 0
NFKBIA 0.031 0.009 -10000 0 -0.067 1 1
IL17A 0.008 0.081 0.26 1 -0.34 1 2
PI3K 0.023 0.12 -10000 0 -10000 0 0
IFNG 0.005 0.017 0.08 3 -0.066 18 21
STAT3 (dimer) 0.032 0.13 -10000 0 -10000 0 0
IL18R1 0.033 0.003 -10000 0 -10000 0 0
IL23/IL23R/JAK2/TYK2/SOCS3 0.009 0.09 0.29 1 -10000 0 1
IL18/IL18R 0.057 0.033 -10000 0 -0.046 44 44
macrophage activation -0.001 0.006 -10000 0 -10000 0 0
TNF 0.006 0.095 -10000 0 -10000 0 0
STAT3/STAT4 0.001 0.1 -10000 0 -10000 0 0
STAT4 (dimer) 0 0.096 -10000 0 -10000 0 0
IL18 0.024 0.026 -10000 0 -0.062 43 43
IL19 0.006 0.11 -10000 0 -10000 0 0
STAT5A (dimer) 0.015 0.12 -10000 0 -10000 0 0
STAT1 0.029 0.018 -10000 0 -0.063 18 18
SOCS3 0.032 0.004 -10000 0 -10000 0 0
CXCL9 -0.003 0.11 -10000 0 -10000 0 0
MPO 0.003 0.11 -10000 0 -10000 0 0
positive regulation of humoral immune response 0.005 0.12 -10000 0 -10000 0 0
IL23/IL23R/JAK2/TYK2 0.006 0.12 -10000 0 -10000 0 0
IL6 0.055 0.13 0.39 10 -10000 0 10
STAT5A 0.032 0.005 -10000 0 -0.063 1 1
IL2 0.033 0.006 -10000 0 -0.036 1 1
positive regulation of tyrosine phosphorylation of STAT protein 0 0.003 -10000 0 -10000 0 0
CD3E 0.002 0.11 -10000 0 -10000 0 0
keratinocyte proliferation 0.005 0.12 -10000 0 -10000 0 0
NOS2 0.005 0.11 -10000 0 -10000 0 0
Rapid glucocorticoid signaling

Figure S127.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S127.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Gs family/GDP/Gbeta gamma 0.034 0.015 -10000 0 -0.022 26 26
MAPK9 0.006 0.001 -10000 0 -10000 0 0
adrenocorticotropin secretion -0.011 0.002 0 8 -0.039 1 9
GNB1/GNG2 0.021 0.005 -10000 0 -10000 0 0
GNB1 0.031 0.008 -10000 0 -10000 0 0
regulation of calcium ion transport via voltage-gated calcium channel activity 0 0 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
MAPK14 0.006 0.002 -10000 0 -0.037 1 1
Gs family/GTP 0.02 0.005 -10000 0 -0.016 8 8
EntrezGene:2778 0 0 -10000 0 -10000 0 0
vasopressin secretion 0 0 -10000 0 -10000 0 0
G-protein coupled receptor activity 0 0 -10000 0 -10000 0 0
ChemicalAbstracts:86-01-1 0 0 -10000 0 -10000 0 0
glutamate secretion 0.003 0 0.005 8 0 7 15
GNAL 0.032 0.006 -10000 0 -10000 0 0
GNG2 0 0 -10000 0 -10000 0 0
CRH 0.032 0.006 -10000 0 -0.063 1 1
mol:cortisol 0 0 -10000 0 -10000 0 0
MAPK8 0.005 0.003 -10000 0 -10000 0 0
MAPK11 0.006 0.002 -10000 0 -10000 0 0
Visual signal transduction: Rods

Figure S128.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S128.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:K + 0.032 0.005 -10000 0 -10000 0 0
GNAT1/GTP 0.023 0.004 -10000 0 0 14 14
Metarhodopsin II/Arrestin 0.042 0.01 -10000 0 -0.04 1 1
PDE6G/GNAT1/GTP 0.043 0.008 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
absorption of light 0 0 -10000 0 -10000 0 0
GNAT1 0.032 0.005 -10000 0 0 14 14
GRK1 0 0 -10000 0 -10000 0 0
CNG Channel 0.059 0.025 -10000 0 -10000 0 0
mol:Na + 0.037 0.018 -10000 0 -10000 0 0
mol:ADP 0 0 -10000 0 -10000 0 0
RGS9-1/Gbeta5/R9AP 0.042 0.01 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
cGMP/CNG Channel 0.047 0.02 -10000 0 -10000 0 0
CNGB1 0.032 0.005 -10000 0 -10000 0 0
RDH5 0.031 0.007 -10000 0 -0.063 1 1
SAG 0.032 0.006 -10000 0 -0.063 1 1
mol:Ca2+ -0.034 0.024 0.15 8 -10000 0 8
Na + (4 Units) 0.035 0.02 -10000 0 -10000 0 0
RGS9 0.032 0.004 -10000 0 -10000 0 0
GNB1/GNGT1 0.031 0.023 -10000 0 -10000 0 0
GNAT1/GDP 0.052 0.02 -10000 0 -0.029 20 20
GUCY2D 0.032 0.005 -10000 0 -10000 0 0
GNGT1 0.023 0.015 -10000 0 -10000 0 0
GUCY2F 0.033 0.001 -10000 0 -10000 0 0
GNB5 0.031 0.006 -10000 0 -10000 0 0
mol:GMP (4 units) -0.028 0.006 -10000 0 -10000 0 0
mol:11-cis-retinal 0.031 0.007 -10000 0 -0.063 1 1
mol:cGMP 0.024 0.009 -10000 0 -0.029 15 15
GNB1 0.031 0.008 -10000 0 -10000 0 0
Rhodopsin 0.045 0.012 -10000 0 -0.049 1 1
SLC24A1 0.032 0.005 -10000 0 -10000 0 0
CNGA1 0.032 0.004 -10000 0 -10000 0 0
Metarhodopsin II 0.02 0.005 -10000 0 -0.016 6 6
mol:Ca ++ 0 0 -10000 0 -10000 0 0
GC1/GCAP Family 0.04 0.011 -10000 0 -0.024 14 14
RGS9BP 0 0 -10000 0 -10000 0 0
Metarhodopsin II/Transducin 0.007 0.028 -10000 0 -0.11 23 23
GCAP Family/Ca ++ 0.021 0.003 -10000 0 -0.016 4 4
PDE6A/B 0.047 0.007 -10000 0 -10000 0 0
mol:Pi 0.041 0.009 -10000 0 -10000 0 0
mol:all-trans-retinal 0 0 -10000 0 -10000 0 0
Transducin 0.039 0.032 -10000 0 -0.032 20 20
PDE6B 0.032 0.004 -10000 0 -10000 0 0
PDE6A 0.032 0.004 -10000 0 -10000 0 0
PDE6G 0.032 0.003 -10000 0 -10000 0 0
RHO 0.032 0.005 -10000 0 -10000 0 0
PDE6 0.074 0.026 -10000 0 -10000 0 0
GUCA1A 0 0 -10000 0 -10000 0 0
GC2/GCAP Family 0.041 0.007 -10000 0 -0.023 5 5
GUCA1C 0 0 -10000 0 -10000 0 0
GUCA1B 0.032 0.004 -10000 0 -10000 0 0
Alternative NF-kappaB pathway

Figure S129.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S129.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IKK alpha homodimer 0.035 0.022 -9999 0 -0.05 3 3
FBXW11 0.032 0.005 -9999 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0 0 -9999 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex 0.032 0.005 -9999 0 -10000 0 0
CHUK 0.024 0.015 -9999 0 -0.063 1 1
NF kappa B2 p100/RelB 0.054 0.066 -9999 0 -10000 0 0
NFKB1 0.031 0.009 -9999 0 -0.063 4 4
MAP3K14 0.032 0.007 -9999 0 -0.063 2 2
NF kappa B1 p50/RelB 0.044 0.015 -9999 0 -0.05 5 5
RELB 0.031 0.008 -9999 0 -0.063 1 1
NFKB2 0.024 0.014 -9999 0 -10000 0 0
NF kappa B2 p52/RelB 0.032 0.02 -9999 0 -0.04 1 1
regulation of B cell activation 0.031 0.02 -9999 0 -0.039 1 1
Ephrin A reverse signaling

Figure S130.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S130.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAPKKK cascade 0.042 0.007 -10000 0 -9999 0 0
EFNA5 0.032 0.004 -10000 0 -9999 0 0
FYN -0.02 0.017 0.18 3 -9999 0 3
neuron projection morphogenesis 0.042 0.007 -10000 0 -9999 0 0
cell-cell signaling 0 0 -10000 0 -9999 0 0
Ephrin A5/EPHA5 0.043 0.007 -10000 0 -9999 0 0
EPHA5 0.032 0.004 -10000 0 -9999 0 0
Class IB PI3K non-lipid kinase events

Figure S131.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S131.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
cAMP biosynthetic process -0.032 0.005 -9999 0 -9999 0 0
PI3K Class IB/PDE3B 0.032 0.005 -9999 0 -9999 0 0
PDE3B 0.032 0.005 -9999 0 -9999 0 0
Inferred Pathway Levels Matrix

Table 3.  Get Full Table First 10 out of 7202 rows and 4 out of 509 columns in the PARADIGM inferred pathway levels matrix.

pid_entity TCGA.87.5896 TCGA.81.5910 TCGA.76.6285 TCGA.76.6282
109_MAP3K5 0.15 0.018 -0.36 0.018
47_PPARGC1A 0.033 0.033 0.033 0.033
105_BMP4 0.033 0.033 0 0.033
105_BMP6 0.033 0.033 0 0.033
105_BMP7 0.033 0.033 0 0.033
105_BMP2 0.033 0.033 -0.063 0.033
131_RELN/VLDLR 0 0 0.084 0
30_TGFB1/TGF beta receptor Type II 0 0.032 0 -0.063
84_STAT5B 0.046 0.035 -0.32 0.035
84_STAT5A 0.046 0.035 -0.32 0.035
Methods & Data
Input

  • Expression Data Normalization = Normal controls were used to median center the expression data used in this analysis.

  • mRNA Expression File Used = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_MergeDataFilesPipeline/GBM-TP/3023688/2.GDAC_MergeDataFiles.Finished/GBM-TP.transcriptome__ht_hg_u133a__broad_mit_edu__Level_3__gene_rma__data.data.txt

  • Copy Number File Used = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Gistic2_Analysis/GBM-TP/3140448/all_data_by_genes.txt

Data Sets and Pathway Interactions

Both copy number and expression data are incorporated into PARADIGM's inference. Whenever normal tissue controls are available for analysis in the expression data, each patient's gene-value is normalized by subtracting the gene's median level observed in the normal control. Copy number data is also normalized to reflect the difference in copy number between a gene's levels detected in tumor versus control (e.g. blood normal). The collection of pathways used by PARADIGM includes those from NCI-PID on September 15, 2009 containing 131 pathways, 11,563 interactions, and 7,204 entities. All gene identifiers were translated into HUGO standard identifiers wherever possible. We refer to molecular entities as "concepts," which include gene products such as proteins and miRNAs, small molecules, protein complexes, and abstract concepts. Each concept is represented as "node" in PARADIGM's graphical model. The abstract concepts correspond to general cellular processes (such as "apoptosis" or "DNA damage response") and families of genes that share functional activity such as the RAS family of signal transducers. Various types of concept-concept interactions are included in the pathways including protein-protein interactions, transcriptional regulatory interactions, and protein modifications such as phosphorylation and ubiquitinylation interactions.

Pathway Inference Method

The PARADIGM algorithm (described in PMID: 20529912) assigns an integrated pathway level (IPL) reflecting the activity of a concept determined through a belief propagation strategy. The belief propagation is given the copy number and gene expression measurements of all of the genes and iteratively updates hidden states reflecting the activities of all of the genes in a pathway so as to maximize the likelihood of the observed data given the interactions in the pathway. In the end, the inferred level of a concept reflects both the data observed for the concept and the neighborhood of activity surrounding the concept.

Determining significantly altered levels

The significance of the IPL obtained for each concept in each patient sample is assessed using a permutation analysis. Importantly, the permutation analysis preserves data tuples so as to preserve any implicit correlations between the different data modalities. For example, genes that are deleted have concomitantly lower expression levels. Preserving the copy number and expression pairs therefore retains this data property. The simulation therefore makes "null samples" by permuting data tuples across all of the genes in the genome so that each gene in a null sample is associated with a random tuple of another gene with equal probability. This approach has the added benefit of preserving the pathway structure so that every observed IPL can be compared to a distribution of random IPLs derived from exactly the same interaction context. PARADIGM inferences are then obtained for 1000 "null" patients and serve as a background distribution to contrast the observed IPLs against. Pathway concepts are excluded from further analysis if they did not obtain a minimum IPL of 0.5 in any patient sample both observed or simulated.

An IPL I(i,j) for concept i in sample j, is considered to be deviated if its absolute level is two standard deviations from the average level observed for concept i in the 1000 null samples. The degree to which a concept has significantly altered levels across a patient cohort is summarized in the proportion of deviated samples (PDS) score. For example, a protein with a PDS of 0.10 reflects that the protein's level of activity was inferred to be significantly higher or lower in tumors compared to normal in 10% of the patient samples. An average PDS for a pathway is also reported by computing the mean PDS over all concepts in the pathway.

Download Results

This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.

References
[2] Charles J. Vaske, Stephen C. Benz, J. Zachary Sanborn, Dent Earl, Christopher Szeto, Jingchun Zhu, David Haussler, and Joshua M. Stuart, Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM, Bioinformatics 12(26):237-245 (2010)
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