E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.003 0.084 -9999.0 0.0 -0.338 11.0 11.0 KLHL20 0.027 0.069 0.184 5.0 -0.267 1.0 6.0 CYFIP2 0.026 0.032 -9999.0 0.0 -0.512 1.0 1.0 Rac1/GDP 0.021 0.076 0.249 1.0 -0.336 1.0 2.0 ENAH -0.005 0.104 -9999.0 0.0 -0.345 15.0 15.0 AP1M1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.022 0.037 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.011 0.029 -9999.0 0.0 -0.18 1.0 1.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.059 0.041 -9999.0 0.0 -0.28 2.0 2.0 RAPGEF1 0.004 0.097 0.302 2.0 -0.446 2.0 4.0 CTNND1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.0 0.109 -9999.0 0.0 -0.353 15.0 15.0 CRK 0.003 0.099 -9999.0 0.0 -0.344 10.0 10.0 E-cadherin/gamma catenin/alpha catenin 0.05 0.046 -9999.0 0.0 -0.445 2.0 2.0 alphaE/beta7 Integrin 0.04 0.025 -9999.0 0.0 -0.372 1.0 1.0 IQGAP1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.05 0.018 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.001 0.082 -9999.0 0.0 -0.341 10.0 10.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.003 0.015 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.047 0.037 -9999.0 0.0 -0.261 3.0 3.0 PI3K 0.007 0.021 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.037 0.049 -9999.0 0.0 -0.522 2.0 2.0 TIAM1 0.023 0.054 -9999.0 0.0 -0.512 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.055 0.037 -9999.0 0.0 -0.253 2.0 2.0 AKT1 0.014 0.03 0.145 1.0 -9999.0 0.0 1.0 PIK3R1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.024 0.044 -9999.0 0.0 -0.512 2.0 2.0 RhoA/GDP 0.03 0.071 0.299 2.0 -0.321 1.0 3.0 actin cytoskeleton organization 0.023 0.054 0.137 10.0 -0.192 1.0 11.0 CDC42/GDP 0.027 0.077 0.299 2.0 -0.321 1.0 3.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.018 0.04 -9999.0 0.0 -0.426 2.0 2.0 ITGB7 0.027 0.031 -9999.0 0.0 -0.512 1.0 1.0 RAC1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.06 0.04 -9999.0 0.0 -0.269 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.041 0.031 -9999.0 0.0 -0.251 2.0 2.0 mol:GDP 0.012 0.083 0.306 2.0 -0.391 1.0 3.0 CDC42/GTP/IQGAP1 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.027 0.031 -9999.0 0.0 -0.512 1.0 1.0 p120 catenin/RhoA/GDP 0.034 0.074 0.352 1.0 -0.305 1.0 2.0 RAC1/GTP/IQGAP1 0.036 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.041 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.011 0.043 0.163 4.0 -0.212 4.0 8.0 NME1 0.028 0.024 -9999.0 0.0 -0.387 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.003 0.1 -9999.0 0.0 -0.348 13.0 13.0 regulation of cell-cell adhesion 0.013 0.03 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.014 0.028 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.033 0.055 0.278 2.0 -0.298 1.0 3.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.073 0.049 -9999.0 0.0 -0.391 2.0 2.0 CCND1 0.013 0.051 0.206 3.0 -0.264 4.0 7.0 VAV2 0.017 0.121 -9999.0 0.0 -0.544 4.0 4.0 RAP1/GDP 0.037 0.066 0.303 2.0 -0.303 1.0 3.0 adherens junction assembly -0.003 0.099 -9999.0 0.0 -0.337 14.0 14.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.053 0.047 -9999.0 0.0 -0.369 2.0 2.0 E-cadherin/beta catenin 0.01 0.031 -9999.0 0.0 -0.354 2.0 2.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.005 0.102 -9999.0 0.0 -0.345 15.0 15.0 PIK3CA 0.021 0.013 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.021 0.068 -9999.0 0.0 -0.342 5.0 5.0 E-cadherin/beta catenin/alpha catenin 0.047 0.037 -9999.0 0.0 -0.295 2.0 2.0 ITGAE 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.0 0.111 -9999.0 0.0 -0.36 15.0 15.0