Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.013 0.087 0.287 22.0 -9999.0 0.0 22.0 KIRREL 0.021 0.038 -9999.0 0.0 -0.52 1.0 1.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.013 0.087 -9999.0 0.0 -0.288 22.0 22.0 PLCG1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.033 0.088 -9999.0 0.0 -0.355 6.0 6.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.008 0.049 -9999.0 0.0 -0.293 2.0 2.0 FYN -0.009 0.08 0.272 8.0 -0.319 6.0 14.0 mol:Ca2+ 0.033 0.084 -9999.0 0.0 -0.349 5.0 5.0 mol:DAG 0.034 0.085 -9999.0 0.0 -0.35 5.0 5.0 NPHS2 -0.012 0.074 -9999.0 0.0 -0.405 9.0 9.0 mol:IP3 0.034 0.085 -9999.0 0.0 -0.35 5.0 5.0 regulation of endocytosis 0.03 0.074 -9999.0 0.0 -0.299 6.0 6.0 Nephrin/NEPH1/podocin/Cholesterol 0.021 0.082 -9999.0 0.0 -0.232 26.0 26.0 establishment of cell polarity 0.013 0.087 -9999.0 0.0 -0.287 22.0 22.0 Nephrin/NEPH1/podocin/NCK1-2 0.04 0.084 -9999.0 0.0 -0.328 5.0 5.0 Nephrin/NEPH1/beta Arrestin2 0.031 0.076 -9999.0 0.0 -0.303 6.0 6.0 NPHS1 -0.021 0.106 -9999.0 0.0 -0.395 21.0 21.0 Nephrin/NEPH1/podocin 0.024 0.076 -9999.0 0.0 -0.321 6.0 6.0 TJP1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.024 0.011 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.035 0.086 -9999.0 0.0 -0.351 5.0 5.0 CD2AP 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.035 0.088 -9999.0 0.0 -0.358 6.0 6.0 GRB2 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.027 0.096 0.282 6.0 -0.248 29.0 35.0 cytoskeleton organization -0.002 0.059 0.209 3.0 -0.297 5.0 8.0 Nephrin/NEPH1 0.015 0.061 -9999.0 0.0 -0.195 22.0 22.0 Nephrin/NEPH1/ZO-1 0.03 0.075 -9999.0 0.0 -0.226 22.0 22.0