Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.253 0.258 -9999.0 0.0 -0.751 31.0 31.0 IHH -0.102 0.239 -9999.0 0.0 -0.831 45.0 45.0 SHH Np/Cholesterol/GAS1 -0.038 0.128 -9999.0 0.0 -0.463 39.0 39.0 LRPAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.037 0.127 0.459 39.0 -9999.0 0.0 39.0 SMO/beta Arrestin2 -0.15 0.155 -9999.0 0.0 -0.607 32.0 32.0 SMO -0.136 0.194 -9999.0 0.0 -0.643 32.0 32.0 AKT1 -0.042 0.091 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.014 0.04 -9999.0 0.0 -0.865 1.0 1.0 BOC 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.135 0.191 -9999.0 0.0 -0.632 32.0 32.0 STIL -0.098 0.17 -9999.0 0.0 -0.679 10.0 10.0 DHH N/PTCH2 -0.045 0.164 -9999.0 0.0 -0.639 34.0 34.0 DHH N/PTCH1 -0.163 0.165 -9999.0 0.0 -0.628 35.0 35.0 PIK3CA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.001 0.11 -9999.0 0.0 -0.758 10.0 10.0 PTHLH -0.449 0.407 -9999.0 0.0 -0.744 301.0 301.0 determination of left/right symmetry -0.135 0.191 -9999.0 0.0 -0.632 32.0 32.0 PIK3R1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.444 0.403 -9999.0 0.0 -0.735 301.0 301.0 IHH N/Hhip -0.207 0.315 -9999.0 0.0 -0.663 149.0 149.0 DHH N/Hhip -0.155 0.26 -9999.0 0.0 -0.586 127.0 127.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.135 0.191 -9999.0 0.0 -0.632 32.0 32.0 pancreas development -0.179 0.337 -9999.0 0.0 -0.766 119.0 119.0 HHAT 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.033 0.188 -9999.0 0.0 -0.762 30.0 30.0 somite specification -0.135 0.191 -9999.0 0.0 -0.632 32.0 32.0 SHH Np/Cholesterol/PTCH1 -0.137 0.147 -9999.0 0.0 -0.677 10.0 10.0 SHH Np/Cholesterol/PTCH2 -0.036 0.131 -9999.0 0.0 -0.511 34.0 34.0 SHH Np/Cholesterol/Megalin -0.048 0.152 -9999.0 0.0 -0.498 46.0 46.0 SHH 0.018 0.087 -9999.0 0.0 -0.581 10.0 10.0 catabolic process -0.159 0.196 -9999.0 0.0 -0.66 31.0 31.0 SMO/Vitamin D3 -0.143 0.153 -9999.0 0.0 -0.587 35.0 35.0 SHH Np/Cholesterol/Hhip -0.122 0.21 -9999.0 0.0 -0.469 125.0 125.0 LRP2 -0.05 0.216 -9999.0 0.0 -0.758 41.0 41.0 receptor-mediated endocytosis -0.156 0.182 -9999.0 0.0 -0.778 19.0 19.0 SHH Np/Cholesterol/BOC -0.009 0.065 -9999.0 0.0 -0.455 10.0 10.0 SHH Np/Cholesterol/CDO -0.072 0.183 -9999.0 0.0 -0.53 65.0 65.0 mesenchymal cell differentiation 0.121 0.208 0.465 125.0 -9999.0 0.0 125.0 mol:Vitamin D3 -0.112 0.175 -9999.0 0.0 -0.68 10.0 10.0 IHH N/PTCH2 -0.087 0.222 -9999.0 0.0 -0.625 67.0 67.0 CDON -0.087 0.283 -9999.0 0.0 -0.865 56.0 56.0 IHH N/PTCH1 -0.162 0.198 -9999.0 0.0 -0.671 31.0 31.0 Megalin/LRPAP1 -0.049 0.159 -9999.0 0.0 -0.57 41.0 41.0 PTCH2 -0.028 0.192 -9999.0 0.0 -0.865 24.0 24.0 SHH Np/Cholesterol -0.01 0.067 -9999.0 0.0 -0.466 10.0 10.0 PTCH1 -0.16 0.197 -9999.0 0.0 -0.663 31.0 31.0 HHIP -0.179 0.338 -9999.0 0.0 -0.767 119.0 119.0