Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.012 0.058 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation -0.016 0.08 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.003 0.099 -9999.0 0.0 -0.758 8.0 8.0 ENAH 0.08 0.064 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.001 0.118 -9999.0 0.0 -0.853 9.0 9.0 EPHA2 0.014 0.035 -9999.0 0.0 -0.758 1.0 1.0 MYO6 0.033 0.099 -9999.0 0.0 -0.798 2.0 2.0 CTNNB1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.008 0.062 -9999.0 0.0 -0.485 8.0 8.0 AQP5 -0.172 0.245 -9999.0 0.0 -0.528 147.0 147.0 CTNND1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.035 0.084 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.019 0.123 -9999.0 0.0 -0.49 14.0 14.0 EGF -0.681 0.232 -9999.0 0.0 -0.758 432.0 432.0 NCKAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.051 0.16 -9999.0 0.0 -0.577 35.0 35.0 cortical microtubule organization -0.016 0.08 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.035 0.08 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.016 0.081 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.013 0.062 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.002 0.031 -9999.0 0.0 -0.523 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.052 0.084 -9999.0 0.0 -0.586 1.0 1.0 PVRL2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.035 0.085 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.002 0.028 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.015 0.151 -9999.0 0.0 -0.758 19.0 19.0 EGFR/EGFR/EGF/EGF -0.354 0.15 -9999.0 0.0 -0.788 26.0 26.0 RhoA/GDP -0.015 0.074 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.042 0.094 -9999.0 0.0 -0.729 2.0 2.0 IGF-1R heterotetramer 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.003 0.106 -9999.0 0.0 -0.865 7.0 7.0 DIAPH1 -0.011 0.09 -9999.0 0.0 -0.701 8.0 8.0 Wnt receptor signaling pathway 0.016 0.08 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.013 0.063 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.042 0.096 -9999.0 0.0 -0.759 2.0 2.0 EFNA1 0.014 0.04 -9999.0 0.0 -0.865 1.0 1.0 LPP 0.045 0.089 -9999.0 0.0 -0.813 1.0 1.0 Ephrin A1/EPHA2 -0.016 0.075 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.013 0.063 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.019 0.125 -9999.0 0.0 -0.5 14.0 14.0 HGF/MET -0.037 0.134 -9999.0 0.0 -0.961 4.0 4.0 HGF -0.021 0.17 -9999.0 0.0 -0.814 21.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.012 0.059 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.1 0.07 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.037 0.129 -9999.0 0.0 -0.874 6.0 6.0 KIFC3 0.034 0.087 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.034 0.093 -9999.0 0.0 -0.875 1.0 1.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.016 0.08 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.035 0.085 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.035 0.085 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.012 0.054 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.059 0.127 -9999.0 0.0 -0.801 7.0 7.0 IGF-1R heterotetramer/IGF1 -0.021 0.087 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.007 0.089 -9999.0 0.0 -0.865 5.0 5.0 PLEKHA7 0.032 0.104 -9999.0 0.0 -0.798 3.0 3.0 mol:GTP -0.002 0.031 -9999.0 0.0 -0.519 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.072 0.076 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.012 0.058 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.042 0.094 -9999.0 0.0 -0.729 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.012 0.059 -9999.0 0.0 -9999.0 0.0 0.0