Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.013 0.056 -9999.0 0.0 -0.442 2.0 2.0 epithelial cell differentiation 0.028 0.069 -9999.0 0.0 -0.343 11.0 11.0 CYFIP2 0.013 0.081 -9999.0 0.0 -0.639 7.0 7.0 ENAH 0.062 0.099 0.394 14.0 -9999.0 0.0 14.0 EGFR 0.019 0.07 -9999.0 0.0 -0.597 6.0 6.0 EPHA2 0.027 0.031 -9999.0 0.0 -0.639 1.0 1.0 MYO6 0.057 0.108 0.391 10.0 -0.489 2.0 12.0 CTNNB1 0.021 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.036 0.06 -9999.0 0.0 -0.404 7.0 7.0 AQP5 -0.107 0.239 -9999.0 0.0 -0.509 99.0 99.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.06 0.104 0.414 9.0 -9999.0 0.0 9.0 regulation of calcium-dependent cell-cell adhesion 0.052 0.115 0.412 9.0 -0.462 1.0 10.0 EGF -0.571 0.198 -9999.0 0.0 -0.634 428.0 428.0 NCKAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.009 0.155 -9999.0 0.0 -0.526 28.0 28.0 cortical microtubule organization 0.028 0.069 -9999.0 0.0 -0.343 11.0 11.0 GO:0000145 0.05 0.103 0.406 9.0 -9999.0 0.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.031 0.071 -9999.0 0.0 -0.347 11.0 11.0 MLLT4 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.007 0.042 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.066 0.037 -9999.0 0.0 -0.37 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.042 0.08 0.374 1.0 -9999.0 0.0 1.0 PVRL2 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.048 0.091 0.357 4.0 -9999.0 0.0 4.0 ARF6/GTP 0.069 0.04 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.007 0.118 -9999.0 0.0 -0.619 16.0 16.0 EGFR/EGFR/EGF/EGF -0.245 0.143 -9999.0 0.0 -0.589 17.0 17.0 RhoA/GDP 0.029 0.066 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.05 0.1 0.348 9.0 -0.458 2.0 11.0 IGF-1R heterotetramer 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.021 0.069 -9999.0 0.0 -0.588 6.0 6.0 DIAPH1 0.03 0.112 -9999.0 0.0 -0.687 6.0 6.0 Wnt receptor signaling pathway -0.028 0.069 0.343 11.0 -9999.0 0.0 11.0 RHOA 0.021 0.013 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.008 0.044 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.023 0.013 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.05 0.102 0.35 9.0 -0.471 2.0 11.0 EFNA1 0.027 0.029 -9999.0 0.0 -0.588 1.0 1.0 LPP 0.047 0.09 0.411 4.0 -9999.0 0.0 4.0 Ephrin A1/EPHA2 0.023 0.063 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.002 0.047 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.052 0.116 0.415 9.0 -0.47 1.0 10.0 HGF/MET 0.013 0.09 -9999.0 0.0 -0.595 3.0 3.0 HGF 0.003 0.12 -9999.0 0.0 -0.593 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.013 0.057 -9999.0 0.0 -0.446 2.0 2.0 actin cable formation 0.105 0.128 0.327 67.0 -9999.0 0.0 67.0 KIAA1543 0.048 0.104 0.352 8.0 -0.54 2.0 10.0 KIFC3 0.051 0.093 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.054 0.098 0.446 6.0 -9999.0 0.0 6.0 NCK1/GIT1 0.041 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.028 0.069 -9999.0 0.0 -0.343 11.0 11.0 EXOC4 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.051 0.091 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.06 0.105 0.416 9.0 -9999.0 0.0 9.0 LIMA1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.074 0.109 0.408 17.0 -9999.0 0.0 17.0 adherens junction assembly 0.071 0.135 0.503 14.0 -0.719 2.0 16.0 IGF-1R heterotetramer/IGF1 0.021 0.071 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.04 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.024 0.041 -9999.0 0.0 -0.588 2.0 2.0 PLEKHA7 0.058 0.106 0.359 8.0 -0.568 2.0 10.0 mol:GTP 0.063 0.036 -9999.0 0.0 -0.368 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.083 0.124 0.378 43.0 -9999.0 0.0 43.0 cortical actin cytoskeleton stabilization 0.013 0.056 -9999.0 0.0 -0.442 2.0 2.0 regulation of cell-cell adhesion 0.05 0.1 0.348 9.0 -0.458 2.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.013 0.057 -9999.0 0.0 -0.446 2.0 2.0