E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.071 0.183 -9999.0 0.0 -0.434 30.0 30.0 KLHL20 -0.022 0.098 0.168 1.0 -0.214 22.0 23.0 CYFIP2 0.026 0.041 -9999.0 0.0 -0.337 2.0 2.0 Rac1/GDP -0.04 0.116 -9999.0 0.0 -0.247 29.0 29.0 ENAH -0.063 0.173 -9999.0 0.0 -0.407 30.0 30.0 AP1M1 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.02 0.094 0.14 1.0 -0.19 28.0 29.0 ABI1/Sra1/Nap1 -0.038 0.06 -9999.0 0.0 -0.161 26.0 26.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.027 0.096 -9999.0 0.0 -0.177 28.0 28.0 RAPGEF1 -0.065 0.147 -9999.0 0.0 -0.352 29.0 29.0 CTNND1 0.024 0.049 -9999.0 0.0 -0.337 3.0 3.0 regulation of calcium-dependent cell-cell adhesion -0.052 0.169 -9999.0 0.0 -0.387 31.0 31.0 CRK -0.064 0.156 -9999.0 0.0 -0.374 29.0 29.0 E-cadherin/gamma catenin/alpha catenin -0.014 0.123 -9999.0 0.0 -0.222 40.0 40.0 alphaE/beta7 Integrin 0.036 0.044 -9999.0 0.0 -0.228 4.0 4.0 IQGAP1 0.029 0.029 -9999.0 0.0 -0.337 1.0 1.0 NCKAP1 -0.001 0.099 -9999.0 0.0 -0.337 13.0 13.0 Rap1/GTP/I-afadin 0.044 0.055 -9999.0 0.0 -0.178 9.0 9.0 DLG1 -0.053 0.16 -9999.0 0.0 -0.386 29.0 29.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.029 0.063 -9999.0 0.0 -0.145 28.0 28.0 MLLT4 0.008 0.083 -9999.0 0.0 -0.337 9.0 9.0 ARF6/GTP/NME1/Tiam1 0.038 0.061 -9999.0 0.0 -0.178 11.0 11.0 PI3K -0.032 0.082 -9999.0 0.0 -0.184 28.0 28.0 ARF6 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.028 0.131 -9999.0 0.0 -0.267 36.0 36.0 TIAM1 0.003 0.091 -9999.0 0.0 -0.337 11.0 11.0 E-cadherin(dimer)/Ca2+ 0.018 0.096 -9999.0 0.0 -0.175 31.0 31.0 AKT1 -0.026 0.049 0.094 1.0 -0.147 9.0 10.0 PIK3R1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.033 0.132 -9999.0 0.0 -0.337 26.0 26.0 RhoA/GDP -0.041 0.118 -9999.0 0.0 -0.244 31.0 31.0 actin cytoskeleton organization -0.013 0.076 0.153 3.0 -0.158 21.0 24.0 CDC42/GDP -0.042 0.119 0.269 1.0 -0.245 31.0 32.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.04 0.109 -9999.0 0.0 -0.213 43.0 43.0 ITGB7 0.023 0.057 -9999.0 0.0 -0.337 4.0 4.0 RAC1 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.02 0.103 -9999.0 0.0 -0.187 31.0 31.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.01 0.085 -9999.0 0.0 -0.172 28.0 28.0 mol:GDP -0.06 0.125 -9999.0 0.0 -0.279 31.0 31.0 CDC42/GTP/IQGAP1 0.04 0.021 -9999.0 0.0 -0.195 1.0 1.0 JUP -0.008 0.111 -9999.0 0.0 -0.337 17.0 17.0 p120 catenin/RhoA/GDP -0.037 0.123 -9999.0 0.0 -0.253 30.0 30.0 RAC1/GTP/IQGAP1 0.036 0.022 -9999.0 0.0 -0.169 1.0 1.0 PIP5K1C/AP1M1 0.044 0.014 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.057 -9999.0 0.0 -0.337 4.0 4.0 positive regulation of S phase of mitotic cell cycle -0.013 0.052 -9999.0 0.0 -0.136 14.0 14.0 NME1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.063 0.166 -9999.0 0.0 -0.394 30.0 30.0 regulation of cell-cell adhesion -0.024 0.079 -9999.0 0.0 -0.169 28.0 28.0 WASF2 -0.01 0.042 0.082 1.0 -0.095 17.0 18.0 Rap1/GTP -0.023 0.104 0.175 2.0 -0.209 28.0 30.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.01 0.123 -9999.0 0.0 -0.191 41.0 41.0 CCND1 -0.016 0.063 -9999.0 0.0 -0.167 14.0 14.0 VAV2 -0.092 0.218 -9999.0 0.0 -0.594 17.0 17.0 RAP1/GDP -0.028 0.11 0.193 1.0 -0.259 14.0 15.0 adherens junction assembly -0.062 0.161 -9999.0 0.0 -0.382 30.0 30.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.002 0.11 -9999.0 0.0 -0.189 38.0 38.0 E-cadherin/beta catenin -0.027 0.102 -9999.0 0.0 -0.274 24.0 24.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.07 0.167 -9999.0 0.0 -0.387 32.0 32.0 PIK3CA 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.063 0.131 -9999.0 0.0 -0.338 23.0 23.0 E-cadherin/beta catenin/alpha catenin 0.01 0.1 -9999.0 0.0 -0.205 28.0 28.0 ITGAE 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.053 0.172 -9999.0 0.0 -0.395 31.0 31.0