Clinical Features	MRNA_CNMF		MRNA_CHIERARCHICAL		CN_CNMF		METHLYATION_CNMF		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
IDH1	165 (76%)	52	0.22462	1	0.32872	1	1.0191e-12	2.28e-10	1.4045e-32	3.3e-30	1.7958e-19	4.15e-17	0.059545	1	0.068422	1	0.10647	1
IDH2	9 (4%)	208	NA	NA	NA	NA	0.10343	1	0.075031	1	0.050122	1	0.0015792	0.314	0.020678	1	0.509	1
IL32	6 (3%)	211	NA	NA	NA	NA	0.060868	1	0.021387	1	0.32993	1	0.3037	1	0.35665	1	0.2804	1
TP53	113 (52%)	104	0.1134	1	0.15719	1	2.7755e-23	6.47e-21	6.4228e-42	1.52e-39	9.5906e-16	2.19e-13	5.0119e-12	1.12e-09	0.00089136	0.18	0.018145	1
PIK3R1	14 (6%)	203	0.61538	1	0.59385	1	0.0052621	1	0.092118	1	0.50002	1	0.45078	1	0.87498	1	1	1
PIK3CA	19 (9%)	198	NA	NA	NA	NA	0.00050947	0.103	0.00019336	0.0398	0.064206	1	0.34459	1	0.39979	1	0.24587	1
ATRX	93 (43%)	124	0.02561	1	0.021979	1	3.04e-15	6.9e-13	3.4775e-29	8.14e-27	1.1663e-16	2.67e-14	1.1486e-08	2.49e-06	0.001909	0.378	0.048488	1
FUBP1	22 (10%)	195	0.023134	1	0.045926	1	1.0571e-09	2.31e-07	8.1283e-10	1.79e-07	1.9759e-08	4.27e-06	2.005e-07	4.31e-05	0.019396	1	0.22176	1
CIC	41 (19%)	176	0.05016	1	0.062505	1	6.2167e-19	1.43e-16	1.5321e-22	3.55e-20	4.9828e-13	1.12e-10	5.575e-15	1.26e-12	1.4292e-06	0.000304	0.0046819	0.913
NOTCH1	19 (9%)	198	0.61538	1	0.45846	1	1.014e-05	0.00212	6.0293e-06	0.00127	0.00014344	0.0297	2.6532e-05	0.00552	0.003226	0.632	0.00094102	0.189
PTEN	12 (6%)	205	NA	NA	NA	NA	6.1925e-09	1.35e-06	4.6331e-10	1.02e-07	2.4282e-11	5.39e-09	0.0019407	0.382	0.00029369	0.0602	0.017377	1
NF1	16 (7%)	201	NA	NA	NA	NA	0.045095	1	1.9449e-06	0.000412	0.0010081	0.202	0.77428	1	0.42614	1	0.55086	1
ZNF844	6 (3%)	211	NA	NA	NA	NA	1	1	0.53414	1	0.4418	1	0.62842	1	0.18455	1	1	1
TCF12	9 (4%)	208	NA	NA	NA	NA	0.90747	1	0.70319	1	0.5707	1	0.1925	1	0.39006	1	0.81241	1
ZBTB20	10 (5%)	207	NA	NA	NA	NA	0.41514	1	0.33937	1	0.56172	1	0.9081	1	0.91137	1	0.45006	1
TIMD4	6 (3%)	211	NA	NA	NA	NA	0.57669	1	0.87098	1	0.71133	1	0.85794	1	0.5538	1	0.75358	1
CREBZF	4 (2%)	213	NA	NA	NA	NA	0.16062	1	0.24841	1	0.35603	1	0.058132	1	0.34334	1	0.076852	1
ZNF57	6 (3%)	211	NA	NA	NA	NA	0.13114	1	0.21818	1	0.097553	1	0.085037	1	0.027388	1	0.3818	1
ARID1A	13 (6%)	204	NA	NA	NA	NA	0.86619	1	0.65109	1	0.38103	1	0.27746	1	0.33919	1	0.74465	1
EGFR	10 (5%)	207	NA	NA	NA	NA	7.4266e-06	0.00156	3.0127e-07	6.45e-05	0.00050105	0.102	0.44975	1	0.16237	1	0.83507	1
EMG1	4 (2%)	213	NA	NA	NA	NA	0.68252	1	0.68119	1	0.97047	1	0.64229	1	0.22589	1	0.67966	1
PRAMEF11	6 (3%)	211	NA	NA	NA	NA	1	1	0.32761	1	0.21293	1	0.24171	1	0.22237	1	0.026904	1
PRDM9	6 (3%)	211	NA	NA	NA	NA	0.65881	1	0.21818	1	0.30476	1	0.85794	1	0.43748	1	1	1
NOX4	5 (2%)	212	NA	NA	NA	NA	0.10165	1	0.91562	1	0.59444	1	0.23846	1	0.8652	1	0.32268	1
ANKRD30A	8 (4%)	209	NA	NA	NA	NA	0.5288	1	0.4088	1	0.84091	1	1	1	0.50329	1	0.30241	1
MUC7	5 (2%)	212	NA	NA	NA	NA	0.23984	1	0.25556	1	0.40061	1	0.5696	1	0.80528	1	0.72046	1
PAX4	5 (2%)	212	NA	NA	NA	NA	0.45264	1	0.91562	1	0.75684	1	0.70521	1	0.4728	1	0.72046	1
ZNF845	6 (3%)	211	NA	NA	NA	NA	0.27827	1	0.92907	1	0.71133	1	0.62842	1	0.83942	1	0.53498	1
C15ORF2	8 (4%)	209	NA	NA	NA	NA	0.23935	1	0.33904	1	0.013224	1	0.31837	1	0.6902	1	0.30241	1
SPDYE5	4 (2%)	213	NA	NA	NA	NA	0.052597	1	0.033782	1	0.056488	1	0.28643	1	0.07123	1	0.25014	1
SCAF1	4 (2%)	213	NA	NA	NA	NA	1	1	1	1	0.42434	1	0.37331	1	0.085343	1	1	1
FSTL5	6 (3%)	211	NA	NA	NA	NA	0.060868	1	0.30442	1	0.11781	1	0.025615	1	0.087529	1	0.3818	1
C9ORF79	8 (4%)	209	NA	NA	NA	NA	1	1	0.46677	1	0.6574	1	0.77925	1	0.79222	1	0.80113	1
ZCCHC12	3 (1%)	214	NA	NA	NA	NA	0.05432	1	0.081584	1	0.54599	1	0.14448	1	0.43372	1	0.19109	1
SMARCA4	13 (6%)	204	NA	NA	NA	NA	0.71439	1	0.61204	1	0.50002	1	0.6758	1	0.35005	1	0.41182	1
MYH4	5 (2%)	212	NA	NA	NA	NA	0.45264	1	0.91562	1	0.41843	1	0.10726	1	0.0084558	1	0.72046	1
TRDN	4 (2%)	213	NA	NA	NA	NA	0.44753	1	1	1	0.97047	1	0.64229	1	1	1	0.42747	1